Medical biological cell collection and sampling device and method

Abstract

The present invention relates to a medical biological cell collection and sampling device and method. The device includes at least a collection chamber. Multiple collection chambers can be configured as an ellipsoid. The ellipsoid can enter the patient's digestive tract. Multiple sampling grooves are provided on the surface of the ellipsoid close to the digestive tract. A cell brush is provided between the sampling grooves. The cell brush can at least be used to scrape cells in the digestive tract. The sampling grooves are used to capture cells scraped by the cell brush and / or tissue fluid in the digestive tract. An inertial unit is provided in the ellipsoid for measuring the motion state of the ellipsoid. The control unit is configured to be able to regulate the opening direction of the sampling groove and / or the direction of the cell brush based on the motion state of the ellipsoid to avoid iatrogenic damage to the patient's digestive tract caused by the cell brush, while collecting cells scraped by the cell brush and / or tissue fluid in the digestive tract through the sampling groove with the largest collection surface. The collection and sampling method is to perform cell collection and sampling by using the above-mentioned device.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a medical biological cell collection and sampling device and method. Background Art

[0002] Digestive tract tumors are a relatively common condition. Digestive tract tumors are primarily found in the esophagus, stomach, duodenum, and small and large intestines. If a patient experiences tumor growth, the first step is to determine whether it is malignant or benign. Benign tumors can generally be surgically removed, and the prognosis is relatively good. However, malignant tumors, if discovered late, are more difficult to cure. Therefore, digestive tract tumors require early detection and prompt treatment. Otherwise, mid- to late-stage digestive tract tumors are prone to spreading, worsening, and becoming life-threatening. Currently, medical professionals rely on examinations such as gastroscopy, colonoscopy, and X-rays to detect tumors in the esophagus, stomach, small intestine, colon, and rectum. However, these instruments are only available in hospitals with superior medical facilities. Ordinary hospitals lack the necessary equipment, and these procedures can be painful for patients, with potential blind spots. Therefore, a medical biological cell collection and sampling device is needed.

[0003] For example, Chinese patent publication CN108245200B discloses a digestive tract tumor cell collector. The collector includes an upper cell collection chamber, a stomach cell collection chamber, an intestinal cell collection chamber, and a master controller. Each of the upper, stomach, and intestinal cell collection chambers is three-dimensional, crescent-shaped, and together they form an ellipsoid. The master controller is located within the ellipsoid. A soluble capsule shell is wrapped around the outermost portion of the upper cell collection chamber. An electric door is installed within the soluble capsule shell. A pressure sensor is mounted on the surface of the electric door. A first chamber is located within the electric door, and a sampling groove is provided on the outer surface of the first chamber. However, the invention still has the following technical deficiencies: 1) Since the cell brush of the invention needs to scrape the inner wall of the digestive tract, the cell brush needs to have a certain hardness to complete the scraping action. However, when the cell brush has a certain hardness, if the angle between the cell brush and the surface of the inner wall of the digestive tract is less than ninety degrees when the cell brush scrapes the surface of the inner wall of the digestive tract, the cell brush (such as the brush rod of the cell brush) is easy to pierce the inner wall of the digestive tract, thereby causing iatrogenic damage to the patient's digestive tract (such as puncturing the surface of the digestive tract and bleeding), and increasing the patient's discomfort; in addition, bloody cell samples often require Special treatment is required before use, which not only increases the workload of medical staff, but also easily increases the risk of infection for medical staff; 2) Since the sampling groove of the invention is fixedly connected to the collection chamber, that is, the opening direction of the sampling groove cannot automatically adapt to the movement direction of the sampling groove and the cell brush corresponding to the sampling groove. For example, when the cell brush scrapes off cells and tissue fluid, the opening direction of the sampling groove is perpendicular to or deviates from the movement direction of the point where the sampling groove is located, so that the sampling groove can only collect a small part of the cells and tissue fluid scraped by the cell brush, or is completely unable to capture the cells and tissue fluid scraped by the cell brush.

[0004] In addition, on the one hand, there are differences in understanding among those skilled in the art; on the other hand, the applicant studied a large number of documents and patents when making the present invention, but due to space limitations, not all details and contents are listed in detail. However, this does not mean that the present invention does not have the characteristics of these prior arts. On the contrary, the present invention already has all the characteristics of the prior art, and the applicant reserves the right to add relevant prior art to the background technology. Summary of the Invention

[0005] Since the cell brush of the existing cell sampling device needs to scrape the inner wall of the digestive tract, the cell brush needs to have a certain hardness to complete the scraping action. However, when the cell brush has a certain hardness, if the angle between the cell brush and the surface of the inner wall of the digestive tract is less than 90 degrees when the cell brush rushes against the surface of the inner wall of the digestive tract, the cell brush (such as the brush rod of the cell brush) is likely to pierce the inner wall of the digestive tract and cause bleeding during sampling, thereby causing iatrogenic damage to the patient's digestive tract (such as puncturing the surface of the digestive tract and causing bleeding) and increasing the patient's discomfort. In addition, bloody cell samples often require special processing before use, which not only increases the workload of medical staff, but also easily increases the risk of infection for medical staff. More importantly, the sampling groove of the existing cell sampling device is fixedly connected to the collection chamber, that is, the opening direction of the sampling groove cannot automatically adapt to the movement direction of the sampling groove and the cell brush corresponding to the sampling groove. For example, when the cell brush scrapes off cells (and tissue fluid), the opening direction of the sampling groove is perpendicular to or deviates from the movement direction of the point where the sampling groove is located, so that the sampling groove can only collect a small part of the cells and tissue fluid scraped by the cell brush, or is completely unable to capture the cells and tissue fluid scraped by the cell brush.

[0006] In view of the shortcomings of the prior art, the present invention provides a medical biological cell collection and sampling device and method. The device comprises at least a plurality of collection chambers.

[0007] Multiple collection chambers can be constructed into an ellipsoid. The ellipsoid can enter the patient's digestive tract. A plurality of sampling grooves are provided on the surface of the ellipsoid close to the digestive tract. A cell brush is provided between the sampling grooves. The cell brush can at least be used to scrape cells in the digestive tract. The sampling groove is used to capture cells scraped by the cell brush and / or tissue fluid in the digestive tract. The control unit is provided inside the ellipsoid. An inertial unit is provided inside the ellipsoid for measuring the motion state of the ellipsoid. When the ellipsoid can move longitudinally along the axial direction of the digestive tract and / or rotate along the long axis of the ellipsoid, the control unit is configured to be able to regulate the opening direction of the sampling groove and / or the direction of the cell brush based on the motion state of the ellipsoid, so as to avoid the cell brush from causing iatrogenic damage to the patient's digestive tract while collecting the cells scraped by the cell brush and / or tissue fluid in the digestive tract through the sampling groove with the largest collection surface.

[0008] According to a preferred embodiment, the device can further include a drive unit. The drive unit is disposed on the surface of the ellipsoid. The drive unit is configured to drive the ellipsoid to move longitudinally along the axial direction of the digestive tract and / or rotate along the long axis of the ellipsoid, so that the cytology brush can scrape cells from the inner wall surface of the digestive tract through the movement of the ellipsoid itself, and collect the cells scraped by the cytology brush and / or tissue fluid in the digestive tract through the sampling groove.

[0009] According to a preferred embodiment, the motion state of the ellipsoid includes at least a first speed of longitudinal movement of the ellipsoid along the axial direction of the digestive tract and a second speed of rotation of the ellipsoid along its own long axis. The base of the cytobrush is provided with a first steering portion for adjusting the direction of the cytobrush so that a first angle between the direction of the cytobrush and the motion direction of the point where the first steering portion is located is greater than ninety degrees.

[0010] According to a preferred embodiment, the control unit can send a first data instruction to the first steering unit corresponding to the cytobrush based on the motion state of the ellipsoid, for adjusting a first angle between the direction the cytobrush is pointing and the motion direction of the point where the first steering unit corresponding to the cytobrush is located. The first steering unit can obtain the first data instruction in real time and adjust the direction of the cytobrush based on the first data instruction so that the first angle between the direction the cytobrush is pointing and the motion direction of the point where the first steering unit corresponding to the cytobrush is located is greater than ninety degrees, thereby preventing the cytobrush from causing iatrogenic damage to the patient's digestive tract.

[0011] The control unit can collect the angle between the brush rod of the cell brush and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the first turning part of the root of the cell brush in real time through the inertial unit.

[0012] Through this configuration, when the control unit detects that the angle between the brush rod of the cell brush and the direction of the third speed formed by the first speed and the second speed of the root of the cell brush is less than ninety degrees, the control unit can send a first data instruction for regulating the first angle between the brush rod of the cell brush and the movement direction of the point where the first steering part corresponding to the cell brush is located to the first steering part corresponding to the cell brush based on the movement state of the ellipsoid, so as to avoid the brush rod of the cell brush directly piercing the inner wall of the digestive tract through which it passes in such a way that the angle between the direction of the brush rod of the cell brush and the direction of the first speed is acute, thereby ultimately avoiding bleeding of the inner wall of the digestive tract during sampling with the cell brush, thereby causing iatrogenic damage and increasing the burden on patients.

[0013] According to a preferred embodiment, a second turning portion is provided at the root of the sampling groove for regulating the opening direction of the sampling groove and adjusting the second angle formed between the opening direction of the sampling groove and the movement direction of the point where the second turning portion corresponding to the sampling groove is located.

[0014] The inertial unit can also measure a second angle between the opening direction of the sampling groove and the movement direction of the point where the second turning part corresponding to the sampling groove is located, and can send the second angle to the control unit in real time.

[0015] According to a preferred embodiment, the control unit can send a second data instruction to the second turning part corresponding to the sampling groove based on the second angle formed between the opening direction of the sampling groove and the movement direction of the point where the second turning part corresponding to the sampling groove is located. The second data instruction is used to regulate the opening direction of the sampling groove so that the second angle between the opening direction of the sampling groove and the movement direction of the point where the second turning part corresponding to the sampling groove is located is always within the threshold angle range during the process of the cell brush scraping off cells, which is conducive to the sampling groove collecting the cells scraped off by the cell brush and / or the tissue fluid in the digestive tract with the largest collection surface.

[0016] Through the above configuration, the control unit can collect in real time the angle between the opening direction of the sampling groove and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part of the sampling groove, and when it is detected that the angle between the opening direction of the sampling groove and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part of the sampling groove is greater than ninety degrees, the control unit can send a signal to the second turning part of the sampling groove for regulating the movement direction of the opening direction of the sampling groove and the point where the second turning part of the sampling groove is located. The second data instruction of the angle formed between the directions is provided, so that the angle formed by the opening direction of the sampling groove and the direction of the third speed formed by the first speed and the second speed of the first turning part corresponding to the cell brush is within the threshold angle range, and the opening direction of the sampling groove always faces the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part of the sampling groove during the process of the ellipsoid moving and / or rotating in the digestive tract, thereby facilitating the opening of the sampling groove to collect cells and tissue fluid on the inner wall of the digestive tract scraped by the cell brush with the largest collection surface.

[0017] According to a preferred embodiment, the collection chambers can be distributed in a circular shape on the surface of the ellipsoid near the digestive tract. The plane of the circular ring formed by the collection chambers is perpendicular or approximately perpendicular to the long axis of the ellipsoid, thereby facilitating the scraping of cells from the inner wall of the digestive tract by a cell brush located on the surface of the ellipsoid as the ellipsoid moves longitudinally along the axial direction of the digestive tract.

[0018] According to a preferred embodiment, the side of the collection chamber facing the digestive tract is wrapped with a soluble capsule shell that can dissolve after contacting the digestive fluid in the digestive tract, so that the cell brush in the collection chamber can contact the digestive tract.

[0019] According to a preferred embodiment, a micro-light assembly and a micro-camera are provided between the sampling grooves. The micro-light assembly is used to illuminate the digestive tract through which the ellipsoid passes after entering the patient's digestive tract. The micro-camera is used to capture images of the digestive tract through which the ellipsoid passes. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is the overall structural intention of a preferred embodiment provided by the present invention;

[0021] Figure 2 This is a schematic diagram of the internal structure of a preferred embodiment of the collection chamber of the present invention;

[0022] Figure 3 It is a schematic diagram of a preferred embodiment of the sampling groove and cell brush of the present invention.

[0023] Reference Signs List

[0024] 1: Collection chamber; 2: Sampling groove 3: Cytobrush;

[0025] 4: Control unit; 5: Inertial unit; 6: Drive unit;

[0026] 301: First turning part; 201: Second turning part; 9: Digestive tract. DETAILED DESCRIPTION

[0027] The following is a detailed description with reference to the accompanying drawings.

[0028] Figure 1 、 Figure 2 and Figure 3 A medical biological cell collection and sampling device is shown.

[0029] like Figure 1 As shown, the device comprises at least a collection chamber 1. The plurality of collection chambers 1 can be configured as an ellipsoid. The ellipsoid can enter the digestive tract 9 of the patient.

[0030] like Figure 2As shown, the surface of the ellipsoid near the digestive tract 9 is provided with multiple sampling grooves 2. A cytology brush 3 is positioned between the sampling grooves 2. The cytology brush 3 is used to at least scrape cells from the digestive tract 9. The sampling grooves 2 are used to capture the cells scraped by the cytology brush 3 and / or the tissue fluid from the digestive tract 9. A control unit 4 is disposed within the ellipsoid. An inertial unit 5 is disposed within the ellipsoid to measure the ellipsoid's motion state.

[0031] When the ellipsoid is able to move longitudinally along the axis of the digestive tract 9 and / or rotate along the long axis of the ellipsoid, the control unit 4 is configured to be able to regulate the opening direction of the sampling groove 2 and / or the direction of the cell brush 3 based on the movement state of the ellipsoid, so as to avoid the cell brush 3 causing iatrogenic damage to the patient's digestive tract 9 while collecting the cells scraped by the cell brush 3 and / or the tissue fluid in the digestive tract 9 through the sampling groove 2 with the largest collection surface.

[0032] Preferably, the collection chamber 1 can be divided into an upper cell collection chamber 1, a stomach cell collection chamber 1 and an intestinal cell collection chamber 1. The planes where the upper cell collection chamber 1, the stomach cell collection chamber 1 and the intestinal cell collection chamber 1 are located can be perpendicular to the long axis direction of the ellipsoid.

[0033] Preferably, the number and types of collection chambers 1 can be flexibly set according to actual application requirements.

[0034] For example, the upper cell collection chamber 1 , the stomach cell collection chamber 1 , and the intestinal cell collection chamber 1 may all be three-dimensional crescent-shaped, and the three together form an ellipsoid.

[0035] The ellipsoid is a three-dimensional structure formed by rotating an ellipse around its major axis.

[0036] The sampling device is roughly in the shape of an ellipsoid, so that the ellipsoid can move longitudinally in a manner parallel or roughly parallel to the axial direction of the digestive tract 9.

[0037] Preferably, the sampling groove 2 may be semi-ellipsoidal in shape.

[0038] Preferably, the sampling groove 2 may also adopt other shapes that are easy to collect the cells scraped by the cell brush 3 and the tissue fluid in the digestive tract 9 .

[0039] Preferably, the maximum length of the ellipsoid along the long axis direction is greater than the maximum diameter of the patient's digestive tract 9 .

[0040] Preferably, the cell brush 3 is disposed on a side of the collection chamber 1 close to the outer surface of the ellipsoid.

[0041] Preferably, the inertial unit 5 is positioned at the geometric center of the ellipsoid. Preferably, the inertial unit 5 is capable of measuring a first velocity of longitudinal movement of the geometric center of the ellipsoid along the axial direction of the digestive tract 9. Preferably, the inertial unit 5 is also capable of measuring a second velocity of rotation of the ellipsoid about the axial direction of the digestive tract 9 or about the long axis of the ellipsoid itself.

[0042] According to a preferred embodiment, Figure 1 As shown, the device can further include a driving unit 6. The driving unit 6 is arranged on the surface of the ellipsoid.

[0043] The driving unit 6 is configured to drive the ellipsoid to move longitudinally along the axial direction of the digestive tract 9 and / or rotate along the long axis of the ellipsoid, so that the cell brush 3 can scrape off the cells on the inner wall surface of the digestive tract 9 through the ellipsoid's own movement, and collect the cells scraped off by the cell brush 3 and / or the tissue fluid in the digestive tract 9 through the sampling groove 2.

[0044] Preferably, the driving part 6 may be provided only at the end of the ellipsoid along its long axis, so that the ellipsoid can only move longitudinally in a manner parallel or substantially parallel to the axial direction of the digestive tract 9 .

[0045] Preferably, the driving part 6 can also be arranged on the circumferential surface of the ellipsoid so that the ellipsoid can rotate around the direction of its own long axis. The number and configuration positions of the driving parts 6 can be flexibly set according to actual needs.

[0046] For example, the cell brush 3 can use its own movement to brush the mucosal cells of the lesions in the digestive tract 9, especially the cells of the ulcer surface, bleeding focus and the wound surface after biopsy.

[0047] In the above manner, after the device enters the patient's digestive tract 9, the cell brush 3 can utilize the movement of the device itself (for example, longitudinal movement along the axis of the digestive tract 9 and / or rotation along the long axis of the ellipsoid itself) to repeatedly brush in the digestive tract 9 (such as the surface of the lesion in the digestive tract 9) to obtain cells (especially diseased cells), thereby complementing the biopsy pathological examination and reducing the missed diagnosis rate of the initial tumor screening.

[0048] According to a preferred embodiment, the motion state of the ellipsoid includes at least: a first speed of the ellipsoid moving longitudinally along the axial direction of the digestive tract 9, and a second speed of the ellipsoid rotating along its own long axis.

[0049] like Figure 3As shown, a first steering portion 301 is provided at the root of the cell brush 3 for regulating the direction in which the cell brush 3 points, so that a first angle between the direction in which the cell brush 3 points and the movement direction of the point where the first steering portion 301 of the cell brush 3 is located is greater than ninety degrees.

[0050] The inertial unit 5 can also measure a first angle between the direction of the cell brush 3 and the movement direction of the point where the first turning portion 301 corresponding to the cell brush 3 is located.

[0051] The inertial unit 5 can send the first angle to the control unit 4 in real time.

[0052] The second speed at which a point located on the circumferential surface of the ellipsoid rotates along the major axis of the ellipsoid itself varies depending on the distance from the end in the major axis direction.

[0053] Preferably, the movement direction of the point where the first turning portion 301 corresponding to the cell brush 3 is located is measured by the first inertial subunit of the inertial unit 5 .

[0054] Preferably, the direction of the cell brush 3 on the ellipsoid is measured by the second inertial subunit of the inertial unit 5 .

[0055] The cell brush 3 is at least composed of a brush rod and bristles. The bristles can be evenly distributed on the circumferential surface of the brush rod.

[0056] The direction of the cell brush 3 refers to the direction of the brush rod.

[0057] Preferably, the root of each cell brush 3 is movably connected to the first turning portion 301 .

[0058] The movement direction of the point where the first turning portion 301 corresponding to the cell brush 3 is located may be the same as or different from the first speed at which the ellipsoid moves longitudinally along the axial direction of the digestive tract 9 .

[0059] The movement direction of the point where the first turning portion 301 corresponding to the cell brush 3 is located may be the same as or different from the second speed at which the point on the circumferential surface of the ellipsoid rotates around the major axis of the ellipsoid itself.

[0060] Preferably, the first turning portion 301 can also enable the cytology brush 3 to rotate along the axial direction of its brush rod, so as to improve the efficiency of the bristles of the cytology brush 3 in scraping off the inner wall tissue of the digestive tract 9 (especially diseased cells).

[0061] According to a preferred embodiment, the control unit 4 can send a first data instruction to the first steering unit 301 corresponding to the cell brush 3 based on the movement state of the ellipsoid, which is used to adjust the first angle between the direction toward which the cell brush 3 is directed and the movement direction of the point where the first steering unit 301 corresponding to the cell brush 3 is located.

[0062] The first steering portion 301 can obtain the first data instruction in real time and adjust the direction of the cell brush 3 based on the first data instruction, so that the first angle between the direction of the cell brush 3 and the movement direction of the point where the first steering portion 301 corresponding to the cell brush 3 is located is greater than ninety degrees, thereby avoiding the cell brush 3 causing iatrogenic damage to the patient's digestive tract 9.

[0063] Preferably, the first data instructions received by the first turning parts 301 corresponding to the cell brushes 3 located on the circumferential surface of the ellipsoid may be different.

[0064] The movement directions and / or speeds of the points where the first turning parts 301 corresponding to the cell brushes 3 located on the circumferential surface of the ellipsoid are located may be the same or different.

[0065] Preferably, each cell brush 3 is equipped with a first turning portion 301 .

[0066] The control unit 4 can collect the angle formed by the direction of the brush rod of the cell brush 3 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the point where the first turning part 301 corresponding to the cell brush 3 is located in real time through the inertial unit 5.

[0067] When the control unit 4 detects that the angle formed between the direction of the brush rod of the cytobrush 3 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed at the point where the first turning portion 301 of the cytobrush 3 is located is less than 90 degrees, the control unit 4 sends a first data instruction to the first turning portion 301 of the cytobrush 3 so that the angle formed between the direction of the brush rod of the cytobrush 3 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed at the point where the first turning portion 301 of the cytobrush 3 is located is greater than 90 degrees and less than 180 degrees. The third speed is the combined speed at the point where the first turning portion 301 of the base of the cytobrush 3 is located.

[0068] For example, Figure 3 As shown, the first speed (i.e. Figure 3 The speed V in the equation is not zero, and the second speed ( Figure 3When the angle between the direction of the brush rod of the cell brush 3 and the direction of the first speed (not shown) is zero, if the control unit 4 detects that the angle between the direction of the brush rod of the cell brush 3 and the direction of the first speed is less than ninety degrees, the control unit 4 sends a first data instruction to the first steering unit 301 corresponding to the cell brush 3, so that the direction of the brush rod of the cell brush 3 is aligned with the first speed (i.e. Figure 3 The angle between the direction of the speed V) can be greater than ninety degrees and less than one hundred and eighty degrees, so that the direction pointed by the brush rod of the cell brush 3 deviates from the direction of the first speed of the ellipsoid moving along the axial direction of the digestive tract 9, thereby preventing the brush rod of the cell brush 3 from directly piercing the inner wall of the digestive tract 9 passed by in a manner that the angle between the direction pointed by the brush rod of the cell brush 3 and the direction of the first speed is acute, and ultimately avoiding bleeding of the inner wall of the digestive tract 9 during sampling by the cell brush 3, thereby causing iatrogenic damage and increasing the burden on patients.

[0069] According to a preferred embodiment, Figure 3 As shown, a second turning portion 201 is provided at the root of the sampling groove 2 for regulating the opening direction of the sampling groove 2 and adjusting the second angle formed between the opening direction of the sampling groove 2 and the movement direction of the point where the second turning portion 201 corresponding to the sampling groove 2 is located.

[0070] The inertial unit 5 can also measure a second angle between the opening direction of the sampling groove 2 and the movement direction of the point where the second turning portion 201 corresponding to the sampling groove 2 is located, and can send the second angle to the control unit 4 in real time.

[0071] Preferably, the opening direction of the sampling groove 2 is measured by the third inertial subunit of the inertial unit 5 .

[0072] Preferably, the first turning portion 301 corresponding to each cytobrush 3 is disposed adjacent to the second turning portion 201 of the sampling recess 2 corresponding to the cytobrush 3 .

[0073] According to a preferred embodiment, the control unit 4 is capable of sending a second data instruction to the second turning portion 201 corresponding to the sampling groove 2 based on a second angle formed between the opening direction of the sampling groove 2 and the movement direction of the point where the second turning portion 201 corresponding to the sampling groove 2 is located. The second data instruction is used to control the opening direction of the sampling groove 2 so that the second angle between the opening direction of the sampling groove 2 and the movement direction of the point where the second turning portion 201 corresponding to the sampling groove 2 is located is always within a threshold angle range during the process of the cell brush 3 scraping off cells, thereby facilitating the sampling groove 2 to collect cells scraped off by the cell brush 3 and / or tissue fluid in the digestive tract 9 with a maximum collection surface.

[0074] The second steering portion 201 can obtain the second data instruction in real time and adjust the direction of the opening of the sampling groove 2 based on the second data instruction, so that the second angle between the opening direction of the sampling groove 2 and the movement direction of the point where the second steering portion 201 corresponding to the sampling groove 2 is located is always within the threshold angle range during the process of the cell brush 3 scraping off cells.

[0075] Preferably, the second turning portion 201 can enable the end of the sampling groove 2 away from the second turning portion 201 to rotate 360 degrees around the normal line of the point where the sampling groove 2 is located.

[0076] Preferably, the second turning portion 201 can also adjust the angle between the axial direction of the sampling groove 2 and the tangent plane at the point where the sampling groove 2 is located.

[0077] Preferably, the sampling groove 2 and the second turning portion 201 corresponding to the cytobrush 3 are arranged closely to the first turning portion 301 corresponding to the cytobrush 3 .

[0078] Preferably, the second turning portion 201 is provided at an end of the sampling groove 2 away from the opening thereof.

[0079] The second steering portion 201 can receive a second data instruction from the control portion 4 and adjust the direction of the opening of the sampling groove 2 based on the second data instruction.

[0080] One cell brush 3 can correspond to at least one sampling recess 2 .

[0081] Preferably, the control unit 4 can collect in real time through the inertial unit 5 the angle formed between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the point where the second turning part 201 of the sampling groove 2 is located.

[0082] When the control unit 4 detects that the angle formed between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part 201 of the sampling groove 2 is greater than ninety degrees, the control unit 4 can send a second data instruction for regulating the opening direction of the sampling groove 2 to the second turning part 201 of the sampling groove 2 based on the movement state of the ellipsoid, so that the angle between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part 201 of the sampling groove 2 is less than ninety degrees.

[0083] For example, Figure 3 As shown, the first speed of the ellipsoidal body's axial translation along the digestive tract 9 (i.e. Figure 3The speed V in the equation is not zero, and the second speed ( Figure 3 When the speed (not shown) is zero, when the control unit 4 detects that the opening direction of the sampling groove 2 is perpendicular to the direction of the first speed of the ellipsoidal translation along the digestive tract 9, the control unit 4 can send a second data instruction to the second steering unit 201 corresponding to the above-mentioned sampling groove 2. The second steering unit 201 can receive the second data instruction from the control unit 4 in real time, and adjust the opening direction of the sampling groove 2 based on the second data instruction, so that the opening direction of the sampling groove 2 is perpendicular to the first speed (i.e. Figure 3 The angle between the directions of the velocity V) is less than ninety degrees.

[0084] Preferably, the second steering unit 201, upon receiving the second data instruction, can ensure that the angle between the opening direction of the sampling groove 2 and the direction of the third speed is within a threshold angle range. The threshold angle range can be flexibly selected based on the actual application scenario. For example, the threshold angle range can be between 30 degrees and 45 degrees.

[0085] The collection surface is the projection area of the opening of the sampling groove 2 in the direction of the third speed.

[0086] Through the above configuration, the control unit 4 can collect in real time the angle between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning portion 201 of the sampling groove 2, and when it is detected that the angle between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning portion 201 of the sampling groove 2 is greater than ninety degrees, the control unit 4 can send a signal to the second turning portion 201 of the sampling groove 2 for regulating the angle between the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning portion 201 of the sampling groove 2. The second data instruction of the angle formed between the movement directions is used to make the angle formed by the opening direction of the sampling groove 2 and the direction of the third speed formed by the first speed and the second speed of the first turning part 301 corresponding to the cell brush 3 within the threshold angle range, so that the opening direction of the sampling groove 2 always faces the direction of the third speed formed by the first speed of the ellipsoid and the second speed of the second turning part 201 of the sampling groove 2 during the process of the ellipsoid moving and / or rotating in the digestive tract 9, thereby facilitating the opening of the sampling groove 2 to collect cells and tissue fluid on the inner wall of the digestive tract 9 scraped by the cell brush 3 with the largest collection surface.

[0087] According to a preferred embodiment, the collection chamber 1 can be distributed in a ring shape on the surface of the ellipsoid near the digestive tract 9. The plane of the ring formed by the collection chamber 1 is perpendicular or approximately perpendicular to the long axis of the ellipsoid, so as to facilitate the cell brush 3 located on the surface of the ellipsoid to scrape cells from the inner wall of the digestive tract 9 when the ellipsoid moves longitudinally along the axial direction of the digestive tract 9.

[0088] Preferably, the upper cell collection chamber 1 , the stomach cell collection chamber 1 and the intestinal cell collection chamber 1 are respectively distributed in a ring shape on one side of the ellipsoid along the radial outward direction thereof.

[0089] Preferably, the upper cell collection chamber 1, the stomach cell collection chamber 1 and the intestinal cell collection chamber 1 are all close to the short axis of the ellipsoid, so that the diameter of the ring formed by the upper cell collection chamber 1, the stomach cell collection chamber 1 and the intestinal cell collection chamber 1 can be maximized, so that the ellipsoid formed by the above-mentioned collection chambers 1 can maintain the maximum contact area with the digestive tract 9 when moving longitudinally along the axial direction of the digestive tract 9, and then more cells on the inner wall of the digestive tract 9 and / or tissues and tissue fluid in the digestive tract 9 can be scraped off by the cell brush 3 provided in each collection chamber 1.

[0090] According to a preferred embodiment, the side of the collection chamber 1 facing the digestive tract 9 is wrapped with a soluble capsule shell. The soluble capsule shell can dissolve after contacting the digestive fluid in the digestive tract 9, so that the cell brush 3 in the collection chamber 1 can contact the digestive tract 9.

[0091] Preferably, the gastric cell collection chamber 1 and the intestinal cell collection chamber 1 have the same internal structure as the upper cell collection chamber 1. The only difference between the three is that the dissolving capsule shell on the surface of the upper cell collection chamber 1 is a saliva-soluble capsule shell; the dissolving capsule shell on the surface of the gastric cell collection chamber 1 is a gastric-soluble capsule shell; and the dissolving capsule on the surface of the intestinal cell collection chamber 1 is an enteric-coated capsule shell.

[0092] According to a preferred embodiment, a micro-light assembly and a micro-camera are provided between the sampling grooves 2. The micro-light assembly is used to illuminate the digestive tract 9 through which the ellipsoid passes after entering the patient's digestive tract 9. The micro-camera is used to capture images of the digestive tract 9 through which the ellipsoid passes.

[0093] Preferably, the micro camera can transmit the image of the digestive tract 9 to an external receiver by wireless transmission and display it, so that medical staff can promptly observe the image of the inside of the digestive tract 9 taken by the device in the patient's digestive tract 9.

[0094] A first chamber door is provided at the bottom of the sampling recess 2. A second chamber is provided within the first chamber. A second chamber is provided on the outer surface of the second chamber. A control chamber is provided in the middle of the second chamber. A battery, a main controller, and a wireless transmitter are mounted within the control chamber.

[0095] A third chamber is disposed within the second chamber. A third chamber door is disposed on the outer surface of the third chamber. The main controller is electrically connected to the pressure sensor, the micro-light assembly, the micro-camera, and the wireless transmitter. The battery is electrically connected to the pressure sensor, the micro-light assembly, the micro-camera, the main controller, and the wireless transmitter.

[0096] The control unit 4 is electrically connected to the main controllers inside the upper cell collection chamber 1 , the stomach cell collection chamber 1 , and the intestinal cell collection chamber 1 .

[0097] The first, second, and third chamber doors are all one-way doors and can only swing inward. The first chamber door is smaller than the second chamber door. The second chamber door is smaller than the third chamber door. The second chamber door is located at the end of the second chamber. The third chamber door is located at the end of the third chamber.

[0098] There are multiple sampling grooves 2, which are evenly distributed on the outer surface of the first chamber. There are multiple pressure sensors.

[0099] The present invention also provides a method for collecting and sampling medical biological cells, which is as follows:

[0100] When cancer screening is required, patients should fast the day before the screening and take laxatives at night to cleanse their stomach and intestines and fast on the day of the examination;

[0101] On the examination day, the patient needs to hold the device in his mouth for a certain period of time to allow saliva to dissolve the capsule shell, thereby triggering the pressure sensor on the upper cell collection chamber 1 and transmitting the signal to the control unit 4 through the main controller in the upper cell collection chamber 1. The control unit 4 sends a command to open the electric door in the upper cell collection chamber 1;

[0102] The patient then swallows the device. The upper cell collection chamber 1 then scrapes cells from the lining of the upper digestive tract 9 using a brush, filling the circular groove. The body's internal pressure then opens the first, second, and third chamber doors, allowing the cells from the upper digestive tract 9 to pass through the second chamber and finally into the third chamber for storage. A micro-light assembly illuminates the inner wall of the digestive tract 9.

[0103] The micro camera is used to capture the inner wall of the digestive tract 9 and transmit the captured image to the control unit 4, which controls the wireless transmitter to transmit the information to the wireless receiving terminal of the medical staff;

[0104] When the device flows into the stomach, the gastric juice in the stomach dissolves the capsule shell, thereby triggering the pressure sensor on the gastric cell collection chamber 1. After that, the control unit 4 sends a command to close the electric door of the upper cell collection chamber 1 and open the electric door of the gastric cell collection chamber 1 at the same time, thereby collecting cells within the stomach range;

[0105] When the device moves to the intestine, the intestinal secretions dissolve the enteric-soluble capsule shell, thereby triggering the pressure sensor on the intestinal cell collection chamber 1. Then the control unit 4 sends a command to close the electric door of the gastric cell collection chamber 1 and open the electric door of the intestinal cell collection chamber 1 at the same time, thereby collecting cells within the intestinal range;

[0106] Finally, the device is excreted from the body.

[0107] It should be noted that the above-mentioned specific embodiments are exemplary, and those skilled in the art can come up with various solutions inspired by the disclosure of the present invention, and these solutions also belong to the disclosure scope of the present invention and fall within the protection scope of the present invention. Those skilled in the art should understand that the present invention specification and its drawings are illustrative and do not constitute a limitation of the claims. The scope of protection of the present invention is defined by the claims and their equivalents. The present invention specification contains multiple inventive concepts, such as "preferably", "according to a preferred embodiment" or "optionally", all of which indicate that the corresponding paragraph discloses an independent concept, and the applicant reserves the right to file a divisional application based on each inventive concept. Throughout the text, the features guided by "preferably" are only an optional method and should not be understood as having to be set, so the applicant reserves the right to abandon or delete the relevant preferred features at any time.

Claims

1. A medical biological cell collection and sampling device, comprising at least: A collection chamber (1), wherein a plurality of the collection chambers (1) can be configured as an ellipsoid, and the ellipsoid can enter the digestive tract (9) of a patient; Sampling grooves (2) are arranged on the surface of the ellipsoid close to the digestive tract (9), and a cell brush (3) is arranged between the plurality of sampling grooves (2). The cell brush (3) can at least be used to scrape off cells in the digestive tract (9), and the sampling grooves (2) are used to capture the cells scraped off by the cell brush (3) and / or the tissue fluid in the digestive tract (9); A control unit (4) is arranged inside the ellipsoid; The invention is characterized in that an inertial unit (5) is provided in the ellipsoid for measuring the motion state of the ellipsoid; In the case where the ellipsoid is capable of longitudinal movement along the axial direction of the digestive tract (9) and / or rotation along the long axis of the ellipsoid, the control unit (4) is configured to be capable of regulating the opening direction of the sampling groove (2) and / or the direction of the cell brush (3) based on the motion state of the ellipsoid, so as to avoid the cell brush (3) causing iatrogenic damage to the patient's digestive tract (9) while collecting the cells scraped by the cell brush (3) and / or the tissue fluid in the digestive tract (9) through the sampling groove (2) with the largest collection surface; The root of the cell brush (3) is provided with a first steering portion (301) for regulating the direction in which the cell brush (3) points, so that a first angle between the direction in which the cell brush (3) points and the movement direction of the point where the first steering portion (301) corresponding to the cell brush (3) is located is greater than ninety degrees; The control unit (4) is capable of sending a first data instruction for regulating a first angle between the direction toward which the cell brush (3) is directed and the movement direction of the point at which the first steering unit (301) corresponding to the cell brush (3) is located to the first steering unit (301) corresponding to the cell brush (3) based on the movement state of the ellipsoid; A second steering portion (201) is provided at the root of the sampling groove (2) for regulating the opening direction of the sampling groove (2) and adjusting a second angle formed between the opening direction of the sampling groove (2) and the movement direction of the point where the second steering portion (201) corresponding to the sampling groove (2) is located, wherein the inertial unit (5) is further capable of measuring the second angle between the opening direction of the sampling groove (2) and the movement direction of the point where the second steering portion corresponding to the sampling groove (2) is located, and is capable of sending the second angle to the control unit (4) in real time; The control unit (4) can send a second data instruction to the second steering unit (201) corresponding to the sampling groove (2) based on a second angle formed between the opening direction of the sampling groove (2) and the movement direction of the point where the second steering unit (201) corresponding to the sampling groove (2) is located, so that the second angle is always within the threshold angle range during the process of the cell brush (3) scraping off cells, which is conducive to the sampling groove (2) collecting the cells scraped off by the cell brush (3) and / or the tissue fluid in the digestive tract (9) with the largest collection surface.

2. The sampling device according to claim 1, characterized in that: It can also include a driving portion (6), wherein the driving portion (6) is arranged on the surface of the ellipsoid, The driving portion (6) is configured to drive the ellipsoid to move longitudinally along the axis of the digestive tract (9) and / or rotate along the long axis of the ellipsoid, so that the cell brush (3) can scrape off cells on the inner wall surface of the digestive tract (9) through which the ellipsoid passes through by the movement of the ellipsoid itself, and collect the cells scraped off by the cell brush (3) and / or the tissue fluid in the digestive tract (9) through the sampling groove (2).

3. The sampling device according to claim 1, characterized in that: The motion state of the ellipsoid measured by the inertial unit (5) includes at least: a first speed of the ellipsoid moving longitudinally along the axial direction of the digestive tract (9), and a second speed of the ellipsoid rotating along its own long axis.

4. The sampling device according to claim 1, characterized in that: The first steering portion (301) can acquire the first data instruction in real time, and regulate the direction of the cell brush (3) based on the first data instruction, so that the first angle between the direction of the cell brush (3) and the movement direction of the point where the first steering portion (301) corresponding to the cell brush (3) is located is greater than ninety degrees, thereby preventing the cell brush (3) from causing iatrogenic damage to the patient's digestive tract (9).

5. The sampling device according to any one of claims 1 to 4, characterized in that: The collection chamber (1) can be distributed in a ring shape on the surface of one side of the ellipsoid close to the prime digestive tract (9), wherein the plane where the ring formed by the collection chamber (1) is located is perpendicular or approximately perpendicular to the long axis of the ellipsoid, so as to facilitate the cell brush (3) located on the surface of the ellipsoid to scrape cells on the inner wall of the digestive tract (9) when the ellipsoid moves longitudinally along the axial direction of the digestive tract (9).

6. The sampling device according to any one of claims 1 to 5, characterized in that: The side of the collection chamber (1) facing the digestive tract (9) is wrapped with a soluble capsule shell, and the soluble capsule shell can dissolve after contacting the digestive fluid in the digestive tract (9), so that the cell brush (3) in the collection chamber (1) can contact the digestive tract (9).

7. The sampling device according to any one of claims 1 to 6, characterized in that: A micro-light assembly and a micro-camera are provided between the sampling grooves (2). The micro-light assembly is used to illuminate the digestive tract (9) through which the ellipsoid passes after the ellipsoid enters the patient's digestive tract (9), and the micro-camera is used to capture an image of the digestive tract (9) through which the ellipsoid passes.

Images