A blood separator

Abstract

The present application belongs to the technical field of blood separation, and particularly relates to a blood separator, which comprises an upper chamber, a middle chamber, a lower chamber, a connecting part, an injection hole, an injection needle with an air filter plug, a sealing cap and a sampling port. The injection needle with the air filter plug facilitates blood injection and prevents the blood from being polluted by the external environment. During the separation process, the liquid level in the chamber can be adjusted by extruding the upper chamber or the lower chamber, so that the target product reaches the highest possible purity, and the liquid level adjustment mode effectively solves the problem of liquid leakage. The upper chamber and the middle chamber, and the lower chamber and the middle chamber can be communicated or isolated by controlling the rotation angle of the rotating piston, which is convenient and fast.

Description

Technical Field

[0001] The present invention belongs to the technical field of blood separation, and in particular relates to a blood separator. Background Art

[0002] Platelet-rich plasma (PRP) is a platelet concentrate extracted from whole blood by centrifugation. It contains high concentrations of platelets, white blood cells, and fibrin. Activated platelets secrete various growth factors, white blood cells protect against infection, and fibrin builds the three-dimensional structure necessary for local tissue repair. Concentrated PRP not only provides "concentrated nutrients" for tissue repair but also creates a better environment for tissue repair, promoting and accelerating the repair of bone and soft tissue.

[0003] There are many separators on the market for separating and extracting platelet-rich plasma, but most of them use a rotary push-up method to adjust the liquid level. Although this method can prevent blood contamination, there is a risk of leakage. Summary of the Invention

[0004] The object of the present invention is to provide a blood separator which can not only effectively avoid leakage but also prevent the sample from being contaminated.

[0005] To achieve the above objectives, the technical solution provided by the present invention is:

[0006] A blood separator, comprising:

[0007] An upper chamber, a middle chamber, a lower chamber, a connecting part, an injection hole, an injection needle with an air filter plug, a sealing cap, and a sampling port; wherein the connecting part includes a connecting chamber and a rotary piston.

[0008] Furthermore, in the blood separator of the present invention, the rotary piston is inserted into the connecting cavity and fixed by a buckle, and the rotary piston can rotate in the connecting cavity.

[0009] Furthermore, in the blood separator of the present invention, the connecting cavity and the rotary piston are both provided with a communicating hole;

[0010] When the communicating hole of the connecting chamber is aligned with the communicating hole of the rotary piston, the upper chamber and the middle chamber, or the middle chamber and the lower chamber can be communicated;

[0011] When the communicating hole of the connecting chamber is at an angle of 90° to the communicating hole of the rotary piston, the upper chamber and the middle chamber, or the middle chamber and the lower chamber can be isolated.

[0012] Furthermore, the blood separator described in the present invention is characterized in that: the tail of the rotary piston and one end of the connecting cavity corresponding to the tail of the rotary piston are provided with a limiting structure, which can limit the rotation angle of the rotary piston in the connecting cavity. Specifically, the tail of the rotary piston is provided with a limiting groove or a limiting protrusion, and the end of the connecting cavity corresponding to the tail of the rotary piston is provided with a limiting protrusion or a limiting groove, and the limiting groove is consistent with the limiting protrusion. Preferably, when the rotary piston is at one end of the limiting structure, the connecting hole of the connecting cavity is at 90 degrees or aligned with the connecting hole of the rotary piston, and when the rotary piston rotates to the other end of the limiting structure, the connecting hole of the connecting cavity is aligned or at 90 degrees with the connecting hole of the rotary piston.

[0013] Furthermore, in the blood separator of the present invention, the surface of the rotary piston is wrapped with a sealing layer; the sealing layer can be made of an elastic material.

[0014] Furthermore, in the blood separator of the present invention, a side of the connecting cavity away from the entry end of the rotary piston is in a closed or partially closed form.

[0015] Furthermore, in the blood separator of the present invention, the injection needle with air filter plug comprises a blood inlet, an air filter plug, an air needle hole and a blood needle hole.

[0016] Furthermore, the blood inlet and the sealing cap, as well as the injection port and the sealing cap of the present invention are all connected via threads.

[0017] Furthermore, in the blood separator of the present invention, the top ends of the upper chamber and the lower chamber are made of a soft material, which may be a thermoplastic elastomer, silicone, etc. The liquid level in the chamber can be adjusted by squeezing the upper chamber and the lower chamber.

[0018] Furthermore, in the blood separator of the present invention, the top ends of the upper chamber and the lower chamber are spherical structures.

[0019] Furthermore, in the blood separator of the present invention, the sampling port is arranged in the upper chamber and / or the lower chamber.

[0020] Preferably, in the blood separator of the present invention, the sampling port can be designed as a recessed structure to facilitate identification of the sampling position; the sampling port can be sealed with, but not limited to, dialysis paper to ensure the sterility of the sampling port.

[0021] Furthermore, in the blood separator of the present invention, the injection hole is arranged in the middle chamber or the lower chamber.

[0022] Preferably, in the blood separator of the present invention, a sealing gasket is provided on the inner ring of the screw cap.

[0023] Preferably, in the blood separator of the present invention, the injection hole is provided with a sealing plug to prevent external air from entering the separator.

[0024] The blood separator provided by the present invention can be prepared by welding.

[0025] The blood separator provided by the present invention is columnar as a whole.

[0026] The blood separator provided by the present invention can adjust the liquid level through the deformation of the soft material, so that the target product reaches the highest possible purity, and this method of adjusting the liquid level effectively solves the problem of leakage; by controlling the rotation angle of the rotary piston, the connection and isolation between the upper chamber and the middle chamber, and the middle chamber and the lower chamber can be achieved. It is easy and quick to use, and the probability of operational errors is greatly reduced.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] (1) The blood separator provided by the present invention is provided with an injection needle with an air filter plug, which can facilitate the injection of blood and prevent the external environment from causing contamination to the blood.

[0029] (2) The upper chamber and the lower chamber of the blood separator provided by the present invention are both designed with soft materials. By squeezing the upper chamber or the lower chamber to adjust the liquid level in the chamber, the leakage problem can be effectively solved; by controlling the rotation angle of the rotary piston, the connection and isolation of the connecting hole can be achieved, which is convenient and quick to use.

[0030] (3) The blood separator provided by the present invention is an integrated structure with only one injection hole. This single-hole design can further avoid the risk of leakage. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] Figure 1 It is a schematic diagram of the overall structure of the blood separator of the present invention.

[0032] Figure 2 This is a schematic diagram of the connecting cavity of the blood separator of the present invention.

[0033] Figure 3 This is a schematic diagram of the rotary piston structure of the blood separator of the present invention.

[0034] Figure 4 This is a schematic diagram of the limiting structure of the blood separator of the present invention.

[0035] Figure 5 This is a schematic diagram of the structure of the air filter plug injection needle of the blood separation device of the present invention.

[0036] Among them: 10 upper chamber; 20 middle chamber; 30 lower chamber; 40 connecting part; 41 connecting chamber; 41-1 communicating hole; 41-2 fixing slot; 41-3 limiting slot; 42 rotating piston; 42-1 communicating hole; 42-2 annular protrusion; 42-3 limiting protrusion; 50 injection hole; 60 injection needle with air filter plug; 60-1 blood inlet; 60-2 air filter plug; 60-3 air needle hole; 60-4 blood needle hole; 70 sealing cap; 80 sampling port. DETAILED DESCRIPTION

[0037] In order to make the purpose, technical solutions and advantages of the technical solutions of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. The components of the embodiments of the present invention generally described and shown in the drawings herein can be arranged and designed in various different configurations. Therefore, the following detailed description of the embodiments of the present invention provided in the drawings is not intended to limit the scope of the claimed invention, but merely represents selected embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0038] The following describes embodiments of the present invention in detail, examples of which are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, and are not to be construed as limiting the present invention.

[0039] The present invention will be further described below with reference to the accompanying drawings and specific embodiments.

[0040] like Figure 1 As shown, the blood separator provided by the present invention includes an upper chamber 10, a middle chamber 20, a lower chamber 30, a connecting portion 40, an injection hole 50, an injection needle with an air filter plug 60, a sealing cap 70, and a sampling port 80.

[0041] The upper chamber 10 and the lower chamber 30 are connected to the middle chamber 20 via a connecting portion 40. The connecting portion 40 includes a connecting chamber 41 and a rotary piston 42. The rotary piston 42 is inserted into the connecting chamber 41 and fixed by a buckle. The rotary piston 42 can rotate in the connecting chamber 41. In this embodiment, Figure 2 and Figure 3As shown, the rotary piston head is provided with an annular protrusion 42-2, and the end of the connecting cavity corresponding to the rotary piston head is provided with a fixed groove 41-2. The annular protrusion 42-2 matches the fixed groove 41-2, securing the rotary piston head within the groove and allowing it to rotate around the groove. To prevent leakage, the end of the connecting cavity corresponding to the rotary piston head can be closed or partially closed. In this embodiment, the end of the connecting cavity corresponding to the rotary piston head is closed, but a small hole is left in the middle to facilitate the insertion of the rotary piston 42.

[0042] The connecting chamber 41 of the present invention is provided with a communicating hole 41-1, and the rotary piston is also provided with a communicating hole 42-1; when the communicating hole 41-1 of the connecting chamber is aligned with the communicating hole 42-1 of the rotary piston, the upper chamber 10 and the middle chamber 20, or the middle chamber 20 and the lower chamber 30 can be connected; when the communicating hole 41-1 of the connecting chamber is at 90 degrees to the communicating hole 42-1 of the rotary piston, the upper chamber 10 and the middle chamber 20, or the middle chamber 20 and the lower chamber 30 can be isolated.

[0043] Preferably, the tail of the rotary piston and one end of the connecting cavity corresponding to the tail of the rotary piston are provided with a limiting structure, which can limit the rotation angle of the rotary piston in the connecting cavity. The limiting structure is specifically: a limiting groove or a limiting protrusion is provided at the tail of the rotary piston, and a limiting protrusion or a limiting groove is provided at one end of the connecting cavity corresponding to the tail of the rotary piston, and the limiting groove and the limiting protrusion are consistent. In this embodiment, Figure 4 As shown, the rear end of the rotary piston is provided with a stopper protrusion 42-3. An arc-shaped stopper groove 41-3 is provided at one end of the connecting chamber corresponding to the rear end of the rotary piston. The stopper protrusion 42-3 can move along the stopper groove 41-3. Preferably, the arc length of the stopper groove 41-3 is one-fourth the circumference of the open end. When the rotary piston 42 is at one end of the stopper groove 41-3, the connecting hole 41-1 of the connecting chamber and the connecting hole 42-1 of the rotary piston are at a 90-degree angle or overlap. When the rotary piston moves to the other end of the stopper groove 41-3, the connecting hole 41-1 of the connecting chamber and the connecting hole 42-1 of the rotary piston overlap or are at a 90-degree angle. This design not only allows for precise control of the rotation angle, but also prevents cross-contamination of liquids between the upper and middle chambers, or between the lower and middle chambers. To ensure that the rotation process is leak-proof, the surface of the rotary piston body is coated with a sealing layer, preferably made of an elastomeric material. To facilitate rotation, the rear end of the rotary piston in this embodiment is designed as a rounded rectangular shape.

[0044] The injection hole 50 can be provided in the middle chamber 20 or in the lower chamber 30. In this embodiment, the injection hole 50 is provided on the cavity of the middle chamber 20 close to the upper chamber 10. Preferably, the injection hole is provided with a sealing plug to prevent external air from entering the separator.

[0045] The air filter plug injection needle 60 can be inserted into the injection hole 50 to inject blood into the separator, and the insertion end of the air filter plug injection needle matches the injection hole 50 to seal. Figure 5 As shown in the figure, the air filter plug injection needle 60 includes a blood inlet 60-1, an air filter plug 60-2, an air needle hole 60-3, and a blood needle hole 60-4. When injecting blood into the separator, the blood enters the inside of the separator from the blood inlet 60-1 along the blood needle hole 60-4, and the air inside the separator is discharged from the air filter plug 60-2 along the air needle hole 60-3. The air filter plug 60-2 can balance the air pressure inside and outside the separator and filter out bacteria to ensure the sterility of the inside of the separator.

[0046] The sealing cap 70 can seal the injection hole 50 and the air filter plug injection needle 60. As a preferred embodiment, the blood inlet 60-1 of the air filter plug injection needle 60 and the sealing cap 70, the injection hole 50 and the sealing cap 70 are connected by threads. More preferably, the sealing cap 70 is provided with a sealing gasket.

[0047] The top ends of the upper chamber 10 and the lower chamber 30 are made of soft material, such as thermoplastic elastomer, which can adjust the liquid level in the upper / lower chamber by extrusion. As a preferred embodiment, the volume of the lower chamber 30 is greater than that of the upper chamber 10, which is convenient for the needs of blood separation.

[0048] The upper / lower chamber is connected to the connecting part 40 by welding, but not limited to welding. The middle chamber 20 and the two connecting parts 40 are integrally welded by means of hot plate, ultrasonic wave, laser, etc.

[0049] Taking the separation of platelet-rich plasma as an example, the blood separator provided by the application is used as follows: before injecting whole blood, rotate the rotating piston to make the middle chamber 20 communicate with the lower chamber 30; inject whole blood into the inside of the middle chamber 20 through the air filter plug injection needle 60, then pull out the air filter plug injection needle 60, and tighten the sealing cap 70 on the injection hole 50 to perform the first centrifugation. After centrifugation, the inside liquid is divided into two layers, the upper layer is a mixture of serum and platelets, and the lower layer is mainly red blood cells. Extrude the lower chamber 30 to adjust the liquid level of the lower chamber, so that the red blood cells are mainly concentrated in the lower chamber 30, and the mixture of serum and platelets is mainly concentrated in the middle chamber; rotate the rotating piston 42 to completely close the communication hole 41-1 of the connecting chamber.

[0050] Rotate the blood separator 180° so that the upper chamber 10 faces downward. Shake the liquid in the middle chamber 20 evenly and then perform a second centrifugation. After centrifugation, the upper layer is serum and the lower layer is platelet-rich plasma. Squeeze the upper chamber 10 and adjust the liquid level so that the platelet-rich plasma is primarily concentrated in the upper chamber 10 and the serum is primarily concentrated in the middle chamber 20. Platelet-rich plasma can be extracted through the sampling port 80 provided in the upper chamber. The sampling port 80 can be sealed with, but is not limited to, dialysis paper to ensure sterility. In this embodiment, the sampling port 80 is designed as a recessed structure to facilitate identification of the sampling location.

[0051] The blood separator provided by the present invention can obtain the target separated product or concentrated product through one or two centrifugal separations.

[0052] The separator provided by the present invention can not only separate and collect blood components, but can also be used for separation and extraction of multi-component mixtures in other fields, as long as the mixture can be separated into layers after centrifugation.

[0053] Finally, it should be noted that the embodiments described above are only used to illustrate the technical solutions of the present invention, rather than to limit them. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that the technical solutions described in the aforementioned embodiments can still be modified, or some or all of the technical features therein can be replaced by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. A blood separator, characterized in that: include: An upper chamber (10), a middle chamber (20), a lower chamber (30), a connecting portion (40), an injection hole (50), an injection needle with an air filter plug (60), a sealing cap (70), and a sampling port (80); wherein the connecting portion (40) includes a connecting chamber (41) and a rotary piston (42); The top ends of the upper chamber (10) and the lower chamber (30) are made of soft material; The top ends of the upper chamber (10) and the lower chamber (30) are spherical structures; The rotary piston (42) is inserted into the connecting cavity (41) and fixed by a snap fastener, and the rotary piston (42) can rotate in the connecting cavity (41); The injection needle with air filter plug (60) comprises a blood inlet (60-1), an air filter plug (60-2), an air needle hole (60-3) and a blood needle hole (60-4); The blood inlet (60-1) of the injection needle (60) with an air filter plug and the sealing cap (70), as well as the injection hole (50) and the sealing cap (70) are all connected via threads.

2. The blood separator according to claim 1, characterized in that The connecting cavity (41) is provided with a communicating hole (41-1); the rotary piston (42) is provided with a communicating hole (42-1); When the communicating hole (41-1) of the connecting chamber is aligned with the communicating hole (42-1) of the rotary piston, the upper chamber (10) and the middle chamber (20), or the middle chamber (20) and the lower chamber (30) can be communicated; When the communicating hole (41-1) of the connecting chamber and the communicating hole (42-1) of the rotary piston are at an angle of 90 degrees, the upper chamber (10) and the middle chamber (20), or the middle chamber (20) and the lower chamber (30) can be isolated.

3. The blood separator according to claim 1, characterized in that The tail of the rotary piston and one end of the connecting cavity (41) corresponding to the tail of the rotary piston are provided with a limiting structure, which can limit the rotation angle of the rotary piston in the connecting cavity.

4. The blood separator according to claim 3, characterized in that The limiting structure is specifically as follows: a limiting groove or a limiting protrusion is provided at the tail of the rotary piston (42), and a limiting protrusion or a limiting groove is provided at one end of the connecting cavity (41) corresponding to the tail of the rotary piston, and the limiting groove is consistent with the limiting protrusion.

5. The blood separator according to claim 1, characterized in that The plug body surface of the rotary piston is wrapped with a sealing layer.

6. The blood separator according to claim 1, characterized in that The injection hole (50) is arranged in the middle chamber or the lower chamber.

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