An extrusion injury modeling device

Abstract

The present invention relates to a modeling device for crush injury, comprising a support base, a support plate, a first support rod, a second support rod and a pressing lever; the support plates are arranged on both sides of the support base; both ends of the first support rod and the second support rod are respectively fixed to the support plates on both sides and are arranged in parallel; the second support rod sequentially passes through one or more of the pressing levers, and one end of the pressing lever bypasses the first support rod through a flexible connecting piece and is connected to a heavy object, so that the other end of the pressing lever presses downward on the experimental object on the support base to apply a pressing force. Adopting a pure mechanical structure, using the lever principle to be tractioned by a heavy object, it can achieve a balanced pressing force for a long time. The pressing force can be accurately regulated by the counterweight of the heavy object, with low production and use costs, not involving electric control, and can prevent the problem of program crash during a long-term pressing process, meeting the current concept of low-carbon environmental protection.

Description

Technical Field

[0001] The present invention relates to the technical field of medical experiments, and particularly to a device for establishing a model of crush injury. Background Art

[0002] Crush syndrome, also known as traumatic rhabdomyolysis, mostly occurs in natural disasters such as earthquakes, tsunamis, and debris flows. It refers to the situation where after the muscles in rich parts of the human body such as the limbs or trunk are squeezed for a long time, rhabdomyocytes are damaged, and after the compression is released, some cell contents such as myoglobin and potassium ions enter the blood circulation, causing damage to organs such as the kidneys. In order to improve the diagnosis and treatment efficiency of crush syndrome and analyze the related molecular mechanisms, it is necessary to construct an animal model of crush syndrome, that is, equipment that can generate a certain pressure and maintain the extrusion time is required.

[0003] When establishing a model of crush injury / crush syndrome in experimental mice, it is necessary to apply a certain pressure to the bilateral hind limbs of the experimental mice. After a long period of extrusion, the experimental mice are dissected for sampling and certain physiological and pathological analyses are carried out. Thereby, it provides a theoretical basis for analyzing the physiological and pathological changes of tissues such as muscles and kidneys in the human body after being squeezed for a long time, so as to develop more effective treatment means.

[0004] Currently, the methods for establishing a model of crush injury / crush syndrome adopted in the research on crush syndrome mainly include chemical-induced injury and physical-induced injury. However, most of the existing equipment cannot maintain a balanced extrusion pressure for a long time, and the extrusion pressure cannot be accurately regulated, which easily leads to unreliable authenticity of experimental results. At the same time, a single device can only provide extrusion for one experimental subject and cannot meet the unity of model establishment among different individuals in the same experimental group. Summary of the Invention

[0005] (1) Technical Problems to be Solved

[0006] The present invention aims to solve the technical problems that most of the existing equipment cannot maintain a balanced extrusion pressure for a long time, and the extrusion pressure cannot be accurately regulated, which easily leads to unreliable authenticity of experimental results.

[0007] (2) Technical Solutions

[0008] To solve the above technical problems, the present invention provides a modeling device for crush injury, comprising a support base, a support plate, a first support rod, a second support rod and a pressing lever; the support plates are arranged on both sides of the support base; the two ends of the first support rod and the second support rod are respectively fixed to the support plates on both sides and are arranged in parallel; the second support rod sequentially passes through one or more of the pressing levers, and one end of the pressing lever bypasses the first support rod through a flexible connecting piece and is connected to a heavy object, so that the other end of the pressing lever presses downward on the experimental object on the support base.

[0009] Further, a plurality of fixing devices are arranged on the support base, and the fixing devices are used for fixing the experimental object.

[0010] Further, the fixing device comprises a fixing plate, a head fixing piece, a front limb fixing piece, a hind limb fixing piece and a ventral-dorsal fixing device; the head fixing piece is arranged on the fixing plate and is used for fixing the head of the mouse body; the front limb fixing piece is movably arranged on the fixing plate and is used for fixing the front limbs of the mouse body, a first sliding groove is arranged on the front limb fixing piece, and a first fastening piece for restricting the movement of the first sliding groove is arranged on the fixing plate, and the first sliding groove is sleeved on the first fastening piece and slides relatively; the hind limb fixing piece is movably arranged on the fixing plate and is used for fixing the hind limbs of the mouse body, a second sliding groove is arranged on the hind limb fixing piece, and a second fastening piece for restricting the movement of the second sliding groove is arranged on the fixing plate, and the second sliding groove is sleeved on the second fastening piece and slides relatively; the ventral-dorsal fixing device is arranged on the fixing plate and is used for fixing the ventral and dorsal parts of the mouse body.

[0011] Further, the fixing device is movably connected to the support base through a slide rail.

[0012] Further, a pulley is arranged on the first support rod, the flexible connecting piece is deflected by the pulley, and the pulley can slide and / or rotate relative to the first support rod.

[0013] Further, the installation height of the first support rod is higher than the installation height of the second support rod.

[0014] Further, the pressing lever is connected to the second support rod through a bearing seat, and the pressing lever can slide and / or rotate relative to the second support rod.

[0015] Further, a ejector rod for extrusion is installed at one end of the pressing lever, and a lug for connecting the flexible connecting piece is arranged at the other end, wherein the ratio of the distance from the ejector rod to the bearing seat to the distance from the lug to the bearing seat is 1:4.

[0016] Further, the ejector rod has specifications with different diameters, and the ejector rod is detachably connected to the extrusion lever.

[0017] Further, one or more reinforcing plates are arranged between the support plates and are used to provide support for the first support rod and the second support rod.

[0018] (III) Beneficial effects

[0019] The above technical solutions of the present invention have the following advantages:

[0020] First, a pure mechanical structure is adopted, and the lever principle is used to realize a balanced extrusion force maintained for a long time through the traction of a heavy object. The extrusion force can be accurately regulated by the counterweight of the heavy object, and the production and use costs are low. It does not involve power control and can prevent the problem of program crashes during the long-term extrusion process, which conforms to the current concept of low-carbon environmental protection.

[0021] Second, multiple extrusion levers and fixing devices can be set according to the number of experimental groups to simultaneously extrude multiple experimental objects. The equipment has strong expandability. When in use, a large amount of time and labor costs are saved, the efficiency is improved, and at the same time, the error is greatly reduced, making the results more real and reliable.

[0022] Third, the ratio between the resistance arm and the power arm of the extrusion lever can be adjusted. Therefore, a greater extrusion force can be obtained without changing the counterweight of the heavy object, reducing the counterweight requirement of the heavy object and reducing the wear of the equipment.

[0023] Fourth, the fixing device can be adjusted and the specifications of the pressure rod can be replaced according to experimental objects of different sizes and dimensions, with wide applicability. Description of the drawings

[0024] Figure 1 is a schematic structural diagram of an extrusion injury modeling device of the present invention;

[0025] Figure 2 is Figure 1 a schematic structural diagram of the fixing device in

[0026] Figure 3 is Figure 1 a schematic plan view of the fixing device in

[0027] In the figure: 1, support base; 2, support plate; 3, first support rod; 4, second support rod; 5, extrusion lever; 6, flexible connecting piece; 7, heavy object; 8, fixing device; 81, fixing plate; 82, head fixing piece; 83, front limb fixing piece; 84, hind limb fixing piece; 85, ventral and dorsal fixing device; 86, L-shaped bracket; 87, gate plate; 88, pressing plate; 89, flexible piece; 9, slide rail; 10, pulley; 11, bearing seat; 12, ejector rod; 13, lifting lug; 14, reinforcing plate. DETAILED DESCRIPTION

[0028] The specific implementation of the present invention is further described in detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0029] In the description of the present invention, it is necessary to understand that the terms "center", "longitudinal", "lateral", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first" and "second" are used for descriptive purposes only and cannot be understood as indicating or implying relative importance.

[0030] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be indirectly connected through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] Please refer to Figure 1 The present invention provides a compression injury modeling device, comprising a support seat 1, a support plate 2, a first support rod 3, a second support rod 4 and a compression lever 5; the support seat 1 is provided with the support plates 2 on both sides; the first support rod 3 and the second support rod 4 are respectively fixed to the support plates 2 on both sides and arranged in parallel; the second support rod 4 is sequentially passed through one or more of the compression levers 5, and one end of the compression lever 5 bypasses the first support rod 3 through a flexible connector 6 and is connected to a weight 7, so that the other end of the compression lever 5 exerts a compression force downward on the experimental object on the support seat 1. The lever principle is used to pull through the weight 7 to achieve a long-term balanced compression force, and the compression force can be accurately controlled by the counterweight of the weight 7. The production and use costs are low, and no power control is involved. The problem of program crash during a long period of compression can be prevented, which is in line with the current low-carbon and environmentally friendly concept. The flexible connector 6 can be a cotton rope, a steel cable, a lace, etc., and the weight 7 can be a weight with a weight mark or other substitutes with a known weight.

[0032] Please refer to Figures 2 to 3, in some embodiments, one or more fixing devices 8 are provided on the support base 1, and the fixing devices 8 are used to fix the experimental subject. Further, the fixing device 8 includes a fixing plate 81, a head fixing member 82, a forelimb fixing member 83, a hindlimb fixing member 84, and a ventral-dorsal fixing device 85.

[0033] Wherein the head fixing member 82 is arranged on the fixing plate 81 at the position of the head of the mouse body and is used to fix the head of the mouse body.

[0034] Wherein the forelimb fixing member 83 is movably arranged on the fixing plate 81 at the position of the forelimbs of the mouse body for fixing the forelimbs of the mouse body, and two groups of forelimb fixing members 83 are provided, symmetrically arranged along the center line of the fixing plate 81. A first sliding groove is provided on the forelimb fixing member 83, and a first fastener for restricting the movement of the first sliding groove is provided on the fixing plate 81. The first sliding groove is sleeved on the first fastener and slides relatively. By sliding the first sliding groove on the first fastener, the position of the forelimb fixing plate 81 is adjusted to adapt to the forelimb positions of different experimental mice, and then the forelimb fixing member 83 is fixed by the first fastener. The first fastener can be a bolt, a screw, etc.

[0035] Wherein the hindlimb fixing member 84 is movably arranged on the fixing plate 81 at the position of the hindlimbs of the mouse body for fixing the hindlimbs of the mouse body, and two groups of hindlimb fixing members 84 are provided, symmetrically arranged along the center line of the fixing plate 81. A second sliding groove is provided on the hindlimb fixing member 84, and a second fastener for restricting the movement of the second sliding groove is provided on the fixing plate 81. The second sliding groove is sleeved on the second fastener and slides relatively. By sliding the second sliding groove on the second fastener, the position of the hindlimb fixing plate 81 is adjusted to adapt to the hindlimb positions of different experimental mice, and then the hindlimb fixing member 84 is fixed by the second fastener. The second fastener can be a bolt, a screw, etc.

[0036] Wherein the ventral-dorsal fixing device 85 is arranged on the fixing plate 81 at the position of the ventral-dorsal of the mouse body and is used to fix the ventral-dorsal of the mouse body.

[0037] In some embodiments, the fixing plate 81 is made of stainless steel, which has a long service life. Different from the acrylic material, the fixing plate 81 can be disinfected with alcohol after the experiment to avoid affecting the next use.

[0038] In some embodiments, the head fixing member 82 includes an L-shaped bracket 86 and a shutter 87. The shutter 87 is movably connected to the fixing plate 81 through the L-shaped bracket 86. A third sliding groove is provided on the L-shaped bracket 86, and a third fastener for restricting the movement of the third sliding groove is provided on the fixing plate 81. The third sliding groove is sleeved on the third fastener and slides relatively. By sliding the third sliding groove on the third fastener, the height position of the shutter 87 is adjusted to adapt to the head sizes of different experimental mice, and then the shutter 87 is fixed by the third fastener. The third fastener can be a bolt, a screw, or the like.

[0039] In some embodiments, the shutter 87 is movably arranged on the L-shaped bracket 86. A fourth sliding groove is provided on the shutter 87, and a fourth fastener for restricting the movement of the fourth sliding groove is provided on the L-shaped bracket 86. The fourth sliding groove is sleeved on the fourth fastener and slides relatively. By sliding the fourth sliding groove on the fourth fastener, the position of the shutter 87 is adjusted to adapt to the head positions of different experimental mice, and then the L-shaped bracket 86 is fixed by the fourth fastener. The fourth fastener can be a bolt, a screw, or the like.

[0040] In some embodiments, an arc-shaped hole with a downward opening is formed in the shutter 87 for clamping the head of the mouse body, and the shutter 87 is used to prevent the experimental mouse from turning its head and causing phenomena such as biting itself.

[0041] In some embodiments, both the front limb fixing member 83 and the rear limb fixing member 84 are provided with ends. Grooves are provided on both sides of the ends. During use, the limbs of the mouse body are tied to the ends through medical tape. Due to the provision of the grooves, it is possible to prevent the medical tape from falling off the ends during the struggling process of the mouse body. The medical tape can also be replaced by medical transparent tape, a rope with a suitable thickness and size, or the like.

[0042] In some embodiments, the front limb fixing member 83 and / or the rear limb fixing member 84 are bent. By moving the front limb fixing member 83 and / or the rear limb fixing member 84, the rear limb positions of the mouse body can be adapted to the greatest extent, with wide applicability. At the same time, the front limb fixing member 83 can avoid movement interference with the head fixing member 82 during the movement process.

[0043] In some embodiments, the ventral-dorsal fixing device 85 includes pressing plates 88 and a flexible member 89. The two pressing plates 88 are symmetrically arranged on the fixing plate 81 and are used to fix the flexible member 89. The fixing form is that the pressing plates 88 and the fixing plate 81 press the flexible member 89 against each other, thereby preventing the flexible member 89 from detaching between the pressing plates 88 and the fixing plate 81. Both ends of the flexible member 89 are respectively connected to the two pressing plates 88 and are used to bind the ventral and dorsal sides of the mouse body. The flexible member 89 can be adaptively adjusted according to the size of the ventral and dorsal sides of the mouse body to bind the mouse body and prevent the experimental mouse from escaping.

[0044] In some embodiments, the pressing plates 88 and the fixing plate 81 are connected by a fifth fastener. By disassembling the fifth fastener, the pressing plates 88 and the fixing plate 81 can be separated, which is convenient for disassembly. The fifth fastener can be a bolt, a screw, etc.

[0045] In some embodiments, the flexible member 89 is made of elastic mesh, which has good elasticity and air permeability. When in use, the length of the elastic mesh can be cut according to the size and body shape of the mouse body. The elastic mesh can also be sleeved on the fifth fastener to prevent slipping.

[0046] In the above embodiments, multiple extrusion levers 5 and fixing devices 8 can be set according to the number of experimental groups to simultaneously extrude multiple experimental objects. The equipment has strong expandability. For example, four are set in the figure, but it is not limited to the figure shown. More or fewer can also be set, and all should be included in the protection scope of the present invention. When in use, a large amount of time and labor costs are saved, the efficiency is improved, and at the same time, the error is greatly reduced, making the results more real and reliable.

[0047] In some embodiments, the fixing device 8 is movably connected to the support base 1 through a slide rail 9. The fixing device 8 can be conveniently removed through the slide rail 9, which is convenient for fixing or contacting and fixing the experimental object.

[0048] In some embodiments, a pulley 10 is arranged on the first support rod 3. The flexible connecting member 6 changes direction through the pulley 10. The pulley 10 can slide and / or rotate relative to the first support rod 3, that is, the pulley 10 can be slidably arranged at other positions on the first support rod 3, and at the same time, the pulley 10 can also rotate relative to the first support rod 3 to reduce the rotational friction of the flexible connecting member 6 on the first support rod 3.

[0049] In some embodiments, the installation height of the first support rod 3 is higher than the installation height of the second support rod 4 to satisfy that a heavy object 7 is suspended below the first support rod 3 and an upward pulling force is provided to the extrusion lever 5 through the flexible connecting member 6.

[0050] In some embodiments, the extrusion lever 5 is connected to the second support rod 4 through a bearing seat 11. The extrusion lever 5 can slide and / or rotate relative to the second support rod 4, that is, the extrusion lever 5 can be slidably arranged at other positions of the second support rod 4 through the bearing seat 11 to adjust the force application point of the extrusion lever 5 to ensure compliance with the extrusion position of the experimental subject. At the same time, the extrusion lever 5 can rotate relative to the second support rod 4 through the bearing seat 11 to reduce the rotational friction of the extrusion lever 5 on the second support rod 4.

[0051] In some embodiments, a ejector rod 12 for extrusion is installed at one end of the extrusion lever 5, and a lug 13 for connecting the flexible connector 6 is arranged at the other end. The ratio between the resistance arm and the power arm of the extrusion lever 5 can be adjusted, so a greater extrusion force can be obtained when the counterweight of the heavy object 7 remains unchanged. For example, the ratio of the distance from the ejector rod 12 to the bearing seat 11 to the distance from the lug 13 to the bearing seat 11 is 1:4. Therefore, only a heavy object 7 with a weight one-fourth of the required pressure needs to be connected, which reduces the counterweight requirement of the heavy object 7 and reduces the wear of the equipment.

[0052] In some embodiments, the ejector rod 12 has specifications with different diameters, and the ejector rod 12 is detachably connected to the extrusion lever 5. The fixing device 8 can be adjusted and the specifications of the pressure rod can be replaced according to experimental subjects of different sizes, with wide applicability.

[0053] In some embodiments, one or more reinforcing plates 14 are arranged between the support plates 2 and are used to provide support for the first support rod 3 and the second support rod 4, making the structure more stable and having stronger load-bearing capacity.

[0054] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the technical principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. An extrusion injury modeling device, characterized in that: It includes a support base, a support plate, a first support rod, a second support rod and a pressing lever; The support plates are arranged on both sides of the support base; The two ends of the first support rod and the second support rod are respectively fixed to the support plates on both sides and are arranged in parallel; The second support rod sequentially passes through one or more of the pressing levers. One end of the pressing lever is bypassed around the first support rod through a flexible connecting piece and is connected to a heavy object, so that the other end of the pressing lever presses downward on the experimental object on the support base; the installation height of the first support rod is higher than that of the second support rod; A plurality of fixing devices are arranged on the support base, and the fixing devices are used to fix the experimental object; The pressing lever is connected to the second support rod through a bearing seat, and the pressing lever can slide and / or rotate relative to the second support rod; A push rod for pressing is installed at one end of the pressing lever, and a lug for connecting the flexible connecting piece is arranged at the other end, wherein the ratio of the distance from the push rod to the bearing seat to the distance from the lug to the bearing seat is 1:

4.

2. The a squeezing injury modeling device according to claim 1, wherein: The fixing device includes a fixing plate, a head fixing piece, a front limb fixing piece, a rear limb fixing piece and a ventral and dorsal fixing device; the head fixing piece is arranged on the fixing plate and is used to fix the head of the mouse body; the front limb fixing piece is movably arranged on the fixing plate and is used to fix the front limbs of the mouse body. A first sliding groove is arranged on the front limb fixing piece, and a first fastener for restricting the movement of the first sliding groove is arranged on the fixing plate. The first sliding groove is sleeved on the first fastener and slides relatively; The rear limb fixing piece is movably arranged on the fixing plate and is used to fix the rear limbs of the mouse body. A second sliding groove is arranged on the rear limb fixing piece, and a second fastener for restricting the movement of the second sliding groove is arranged on the fixing plate. The second sliding groove is sleeved on the second fastener and slides relatively; the ventral and dorsal fixing device is arranged on the fixing plate and is used to fix the ventral and dorsal of the mouse body.

3. The extrusion injury modeling device according to claim 1 or 2, characterized in that: The fixing device is movably connected to the support base through a slide rail.

4. The extrusion injury modeling device according to claim 1, wherein: A pulley is arranged on the first support rod, the flexible connecting piece is deflected by the pulley, and the pulley can slide and / or rotate relative to the first support rod.

5. The extrusion injury modeling device according to claim 1, characterized in that: The push rod has specifications with different diameters, and the push rod is detachably connected to the pressing lever.

6. The extrusion injury modeling device according to claim 1, wherein: One or more reinforcing plates are arranged between the support plates and are used to provide support for the first support rod and the second support rod.

Images