Application of polydopamine-coated hemoglobin oxygen carrier in preparation of drugs for promoting wound healing

By using polydopamine-encapsulated hemoglobin oxygen carriers as wound dressings, the problem of poor efficacy of existing dressings in the healing of chronic wounds was solved, resulting in increased wound oxygen content, reduced inflammation, and angiogenesis, thus significantly promoting wound healing.

CN115300615BActive Publication Date: 2026-06-05ACADEMY OF MILITARY MEDICAL SCIENCES
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ACADEMY OF MILITARY MEDICAL SCIENCES
Filing Date
2021-05-08
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Existing wound dressings have limited effectiveness in healing chronic wounds and may delay healing, failing to effectively increase wound oxygen content, reduce inflammation, and promote angiogenesis.

Method used

Polydopamine-encapsulated hemoglobin oxygen carriers were used as wound dressings to improve wound hypoxia, reduce oxidative stress, promote angiogenesis, alleviate inflammation, and promote wound healing.

Benefits of technology

It significantly improves wound healing speed, shortens healing time, increases wound oxygen content, reduces inflammatory response and oxidative stress, and promotes angiogenesis, making it suitable for the treatment of various acute and chronic wounds.

✦ Generated by Eureka AI based on patent content.

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Abstract

The application discloses application of polydopamine-coated hemoglobin oxygen carriers in preparation of wound healing promoting drugs, and the polydopamine-coated hemoglobin oxygen carriers are nanocapsules obtained by coating hemoglobin with polydopamine. The polydopamine-coated hemoglobin oxygen carriers are directly applied on wounds as wound dressings, and are suitable for treatment of various acute and chronic wounds, and the area of wound healing in a unit time is significantly increased, namely, the polydopamine-coated hemoglobin oxygen carriers can improve the speed of wound healing, are beneficial to wound healing, and can shorten the time of wound healing.
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