A fixing device for experimental animals and a magnetic resonance examination device

Abstract

The present invention provides a fixing device for experimental animals and a magnetic resonance examination device, relating to the field of experimental examination devices, and solving the problem that there is a lack of supporting equipment for animal experiments of magnetic wave knives in the current market. The fixing device for experimental animals includes: an examination bed; a first fixing device fixed on the examination bed for fixing the body of the experimental animal; a second fixing device, a third fixing device and a fourth fixing device fixed on the examination bed for fixing the head of the experimental animal, wherein the second fixing device is fixedly connected to the first fixing device; the third fixing device is fixed on the examination bed and fixedly connected to the fourth fixing device; wherein, the third fixing device is an open container, and the head of the experimental animal is placed on the opening of the open container; the fourth fixing device is a fixing bracket for fixing the two ear parts of the head of the experimental animal. The solution of the present invention realizes the treatment research of experimental animals in the field of magnetic wave knives.

Description

Technical Field

[0001] The present invention relates to the field of experimental inspection devices, and particularly to a fixing device for experimental animals and a magnetic resonance inspection device. Background Art

[0002] As a mechanical wave with good directivity, the focusing of ultrasound can bring various biological effects. It has always been one of the important directions for the development of clinical treatment technologies, and has been widely explored and studied in various clinical treatment scenarios. It is particularly important for the development of non-invasive intervention treatment of the brain.

[0003] The new generation of magnetic resonance-guided focused ultrasound technology (MRI Guided Focused Ultrasound, MRgFUS) uses magnetic resonance imaging technology for ultrasonic beam path determination, ablation focusing localization, and real-time monitoring of the target area. It guides the phased array transducer to transmit ultrasound through the skull and focus on the target area, achieving accurate and reliable thermal effects to ablate abnormal nerve nuclei. MRgFUS has many advantages such as no craniotomy anesthesia, real-time positioning adjustment, real-time treatment monitoring, real-time observation of curative effects, repeatable treatment, and no ionizing radiation. It was first introduced into China in 2018 and applied to the clinical treatment of Parkinson's disease, essential tremor, epilepsy, and neuropathic pain. The maturity of MRgFUS technology marks the beginning of the practical clinical application of focused ultrasound treatment for the central nervous system. The current bottleneck in the development of treatment is the further understanding of the target selection of ultrasound ablation treatment and its neural circuit remodeling effect, which requires further animal experiments for testing. Currently, the MRgFUS devices on the market lack supporting animal experiment research devices and cannot meet the research on the treatment targets of magnetic wave knives using experimental animals. Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a fixing device for experimental animals and a magnetic resonance inspection device to realize nuclear magnetic inspection of experimental animals.

[0005] To solve the above technical problem, the technical solution of the present invention is as follows:

[0006] An embodiment of the present invention provides a fixing device for experimental animals, including:

[0007] An examination bed;

[0008] A first fixing device fixed on the examination bed for fixing the body of the experimental animal;

[0009] The second fixing device, the third fixing device and the fourth fixing device that are fixed to the inspection bed for fixing the head of the experimental animal, the second fixing device is fixedly connected to the first fixing device; the third fixing device is fixed to the inspection bed and is fixedly connected to the fourth fixing device;

[0010] Wherein, the second fixing device is an open container, and the head of the experimental animal is placed on the opening of the open container;

[0011] The fourth fixing device is a fixing bracket for fixing the two ear parts of the head of the experimental animal.

[0012] Optionally, the fourth fixing device includes:

[0013] A support base;

[0014] A first clamping plate and a second clamping plate that are respectively and perpendicularly fixedly connected to the support base, and the head of the experimental animal is located between the first clamping plate and the second clamping plate.

[0015] Optionally, the first end of the first clamping plate has a first groove;

[0016] The first end of the second clamping plate has a second groove;

[0017] The support base is snapped into the first groove and the second groove, the first end of the support base is fixedly connected to the first clamping plate, and the second end of the support base is fixedly connected to the second clamping plate.

[0018] Optionally, a first fixing slider is fixedly installed on the first end of the support base, and the first fixing slider is fixedly connected to the outside of the first end of the first clamping plate;

[0019] A second fixing slider is fixedly installed on the second end of the support base, and the second fixing slider is fixedly connected to the outside of the first end of the second clamping plate.

[0020] Optionally, a first sliding groove is provided at the first end of the support base, and a second sliding groove is provided at the second end of the support base.

[0021] Optionally, a third fixing slider is provided at the bottom of the first sliding groove, and the third fixing slider is fixedly connected to the first fixing slider above the first sliding groove;

[0022] There is a fourth fixing slider at the bottom of the second sliding groove, and the fourth fixing slider is fixedly connected to the second fixing slider above the second sliding groove.

[0023] Optionally, the third fixing device includes:

[0024] A fixing base fixed to the inspection bed;

[0025] The first connecting arm and the second connecting arm fixedly connected to the fixed seat;

[0026] The first connecting arm is fixedly connected to the first end of the support seat;

[0027] The second connecting arm is fixedly connected to the second end of the support seat.

[0028] Optionally, both the first connecting arm and the second connecting arm are fixedly connected to the support seat through a support plate.

[0029] Optionally, a phased array ultrasound focusing device for focusing ultrasound is provided in the open container.

[0030] An embodiment of the present invention further provides a magnetic resonance examination device for experimental animals, including: a magnetic resonance main unit and the fixing device for experimental animals as described in any one of the above, and the second fixing device, the third fixing device, and the fourth fixing device of the fixing device for experimental animals are correspondingly arranged with the examination cavity of the magnetic resonance main unit. The above solution of the present invention at least includes the following beneficial effects:

[0031] The above solution of the present invention, through the fixing device for experimental animals including: an examination bed; a first fixing device fixed on the examination bed for fixing the body of the experimental animal; a second fixing device, a third fixing device, and a fourth fixing device fixed on the examination bed for fixing the head of the experimental animal, the second fixing device is fixedly connected to the first fixing device; the third fixing device is fixed on the examination bed and fixedly connected to the fourth fixing device; wherein, the second fixing device is an open container, and the head of the experimental animal is placed on the opening of the open container; the fourth fixing device is a fixing bracket for fixing the two ear parts of the head of the experimental animal. It can realize the fixation of experimental animals during nuclear magnetic examination, is convenient to operate and reliable in work, and realizes the treatment research of experimental animals in the field of magnetic wave knives. Description of the Drawings

[0032] Figure 1 is the overall structural schematic diagram of the magnetic resonance examination device for experimental animals of the present invention;

[0033] Figure 2 is the partial structural schematic diagram of the fixing device for experimental animals of the present invention;

[0034] Figure 3 is the structural schematic diagram of the fourth fixing device of the fixing device for experimental animals of the present invention;

[0035] Figure 4 is the bottom structural schematic diagram of the fourth fixing device of the fixing device for experimental animals of the present invention;

[0036] Figure 5 It is a diagram of the experimental operation of focused ultrasound intervention on the fixing device for experimental animals of the present invention.

[0037] Among them, 1 is the examination bed; 100 is the experimental animal; 2 is the first fixing device; 3 is the second fixing device; 4 is the third fixing device; 411 is the fixing base; 421 is the first connecting arm; 422 is the second connecting arm; 5 is the fourth fixing device; 51 is the support base; 521 is the first fixing slider; 522 is the second fixing slider; 531 is the first clamping plate; 532 is the second clamping plate; 54 is the support plate; 551 is the first sliding groove; 552 is the second sliding groove; 561 is the third fixing slider; 562 is the fourth fixing slider; 6 is the magnetic resonance mainframe. Detailed implementation manners

[0038] Hereinafter, exemplary embodiments of the present disclosure will be described in more detail with reference to the accompanying drawings. Although the exemplary embodiments of the present disclosure are shown in the drawings, it should be understood that the present disclosure can be implemented in various forms and should not be limited by the embodiments set forth herein. On the contrary, these embodiments are provided so that the present disclosure can be more thoroughly understood and the scope of the present disclosure can be fully conveyed to those skilled in the art.

[0039] As Figure 1 shown, an embodiment of the present invention provides a fixing device for experimental animals, including:

[0040] The examination bed 1;

[0041] The first fixing device 2 fixed on the examination bed 1 for fixing the body of the experimental animal 100;

[0042] The second fixing device 3, the third fixing device 4 and the fourth fixing device 5 fixed on the examination bed 1 for fixing the head of the experimental animal 100, the second fixing device 3 is fixedly connected to the first fixing device 2; the third fixing device 4 is fixed on the examination bed 1 and is fixedly connected to the fourth fixing device 5;

[0043] Among them, the second fixing device 3 is an open container, and the head of the experimental animal 100 is placed on the opening of the open container;

[0044] The fourth fixing device 5 is a fixing bracket for fixing the two ear parts of the head of the experimental animal 100.

[0045] In this embodiment, the body of the experimental animal 100 is fixed by the first fixing device 2, the head of the experimental animal 100 is fixed by the second fixing device 3, and then the third fixing device 4 is moved to a position where the fourth fixing device 5 thereon can clamp the head of the experimental animal 100. The two ear parts of the head of the experimental animal 100 are fixed by the fourth fixing device 5, so that the head of the experimental animal 100 is fixed above the opening container of the second fixing device 3. It should be noted that this device is for the equipment of the head magnetic wave knife (i.e., the head knife).

[0046] As Figure 3 shown, in an alternative embodiment of the present invention, the fourth fixing device includes:

[0047] A support base 51; a first clamping plate 531 and a second clamping plate 532 that are respectively vertically and fixedly connected to the support base 51, and the head of the experimental animal 100 is located between the first clamping plate 531 and the second clamping plate 532.

[0048] In an alternative embodiment of the present invention, the first end of the first clamping plate 531 has a first groove; the first end of the second clamping plate 532 has a second groove;

[0049] The support base 51 is snapped into the first groove and the second groove, the first end of the support base 51 is fixedly connected to the first clamping plate 531, and the second end of the support base 51 is fixedly connected to the second clamping plate 532.

[0050] A first fixed slider 521 is fixedly installed on the first end of the support base 51, and the first fixed slider 521 is fixedly connected to the outside of the first end of the first clamping plate 531;

[0051] A second fixed slider 522 is fixedly installed on the second end of the support base 51, and the second fixed slider 522 is fixedly connected to the outside of the first end of the second clamping plate 532.

[0052] In this embodiment, screw holes are provided on the side surfaces of the first ends of the first clamping plate 531 and the second clamping plate 532, and symmetric waist-shaped holes and screw holes are provided on the side surfaces of their second ends. The screw holes on the side surfaces of the first ends are used to be fixedly connected to the outside of the first fixed slider 521 and the second fixed slider 522 respectively by screws; first screws and second screws are respectively arranged on the upper end surfaces of the first fixed slider 521 and the second fixed slider 522 for adjusting the tightness of the first fixed slider 521 and the second fixed slider 522 on the support base 51.

[0053] As Figure 4As shown, in an alternative embodiment of the present invention, a first sliding groove 551 is provided at the first end of the support base 51, and a second sliding groove 552 is provided at the second end of the support base 51.

[0054] A third fixed slider 561 is provided at the bottom of the first sliding groove 551, and the third fixed slider 561 is fixedly connected to a first fixed slider 521 above the first sliding groove 551;

[0055] A fourth fixed slider 562 is provided at the bottom of the second sliding groove 552, and the fourth fixed slider 562 is fixedly connected to a second fixed slider 522 above the second sliding groove 551.

[0056] In this embodiment, both the first sliding groove 551 and the second sliding groove 552 are composed of a small key groove that penetrates a part of the support base 51 and a large key groove that extends upward from the bottom of the support base 51 without penetrating, thereby forming a stepped structure for placing the third fixed slider 561 and the fourth fixed slider 562.

[0057] The first fixed slider 521 and the second fixed slider 522 are respectively fixedly connected to the third fixed slider 561 and the fourth fixed slider 562 through first screws and second screws thereon, so that the first fixed slider 521 and the second fixed slider 522 can slide and be fixed on the support base 51, thereby driving the first clamping plate 531 and the second clamping plate 532 fixed to their sides to clamp the experimental animal 100.

[0058] As Figure 2 shown, in an alternative embodiment of the present invention, the third fixing device 4 includes:

[0059] A fixed seat 411 fixed to the examination bed 1; a first connecting arm 421 and a second connecting arm 422 fixedly connected to the fixed seat 411; the first connecting arm 421 is fixedly connected to the first end of the support base 51; the second connecting arm 422 is fixedly connected to the second end of the support base 51.

[0060] Both the first connecting arm 421 and the second connecting arm 422 are fixedly connected to the support base 51 through a support plate 54.

[0061] In this embodiment, the support plate 54 is vertically fixedly connected to the side of the lower end surface of the support base 51 through screws, and both ends of the support plate 54 are respectively fixedly connected to the first connecting arm 421 and the second connecting arm 422 of the fixed seat 411 through screws, so that the fourth fixing device 5 is fixed on the third fixing device 4.

[0062] As Figure 5As shown, in an alternative embodiment of the present invention, a phased array ultrasonic focusing device for focusing ultrasound is provided in the open container. Specifically, a phased array ultrasonic unit is placed at the bottom of the open container, and water is also stored in the open container to fix the skull of the experimental animal 100 and ensure the contact area of its brain in the water tank.

[0063] As Figure 1 and Figure 2 As shown, another embodiment of the present invention provides a magnetic resonance examination device for experimental animals, comprising:

[0064] A magnetic resonance mainframe 6 and a fixing device for experimental animals as described in the above embodiment, and the second fixing device 3, the third fixing device 4 and the fourth fixing device 5 of the fixing device for experimental animals are correspondingly arranged with the examination cavity of the magnetic resonance mainframe 6.

[0065] In this embodiment, the magnetic resonance mainframe 6 is used to perform experimental operations on the already fixed experimental animal 100.

[0066] The specific working process of the fixing device for experimental animals in this embodiment is as follows: First, turn the phased array water tank (i.e., the open container) of the experimental animal 100's brain by 90 degrees with the opening facing up; place the anesthetized experimental animal 100 on the first fixing device 2, then move the experimental animal 100 so that its head is placed above the opening of the second fixing device 3 (i.e., the open container), and then fix the body of the experimental animal 100 on the first fixing device 2 through a restraint belt. Subsequently, move the third fixing device 4 to a position where the fourth fixing device 5 thereon can clamp the head of the experimental animal 100, and fix the two ear parts of the head of the experimental animal 100 through the first clamping plate 531 and the second clamping plate 532 on the fourth fixing device 5. Finally, push the examination bed 1 to send the fixed experimental animal 100 into the cavity of the magnetic resonance mainframe 6, and perform experimental operations on the experimental animal 100 through the phased array ultrasonic focusing device for focusing ultrasound in the open container and the magnetic resonance mainframe 6. Specifically, use an MR (magnetic resonance) body coil to perform a focused ultrasound intervention experiment under MR guidance. After the experiment, pull out the experimental animal 100 from the magnetic resonance mainframe 6 through the examination bed 1 and remove the experimental animal 100.

[0067] The fixing device for experimental animals of the present invention solves the problem that there is a lack of supporting equipment for animal experiments of magnetic wave knives on the current market, and has the advantages of simple structure, convenient operation and reliable work.

[0068] The above are the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and modifications can be made, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A fixing device for experimental animals, characterized in that, Comprising: Examination bed (1); A first fixing device (2) fixed to the examination bed (1) for fixing the body of the experimental animal (100); A second fixing device (3), a third fixing device (4) and a fourth fixing device (5) fixed to the examination bed (1) for fixing the head of the experimental animal (100), the second fixing device (3) being fixedly connected to the first fixing device (2); the third fixing device (4) is fixed to the examination bed (1) and is fixedly connected to the fourth fixing device (5); Wherein, the second fixing device (3) is an open container, and the head of the experimental animal (100) is placed on the opening of the open container; The fourth fixing device (5) is a fixing bracket for fixing the two ear parts of the head of the experimental animal (100); Wherein, the fourth fixing device (5) comprises: Support seat (51); A first clamping plate (531) and a second clamping plate (532) respectively and perpendicularly fixedly connected to the support seat (51), with the head of the experimental animal (100) located between the first clamping plate (531) and the second clamping plate (532); The third fixing device (4) comprises: A fixed seat (411) fixed to the examination bed (1); A first connecting arm (421) and a second connecting arm (422) fixedly connected to the fixed seat (411); The first connecting arm (421) is fixedly connected to the first end of the support seat (51); The second connecting arm (422) is fixedly connected to the second end of the support seat (51).

2. The fixing device for experimental animals according to claim 1, wherein, The first end of the first clamping plate (531) has a first groove; The first end of the second clamping plate (532) has a second groove; The support seat (51) is snapped into the first groove and the second groove, the first end of the support seat (51) is fixedly connected to the first clamping plate (531), and the second end of the support seat (51) is fixedly connected to the second clamping plate (532).

3. The fixing device for experimental animals according to claim 2, wherein, A first fixing slider (521) is fixedly installed on the first end of the support seat (51), and the first fixing slider (521) is fixedly connected to the outside of the first end of the first clamping plate (531); A second fixing slider (522) is fixedly installed on the second end of the support seat (51), and the second fixing slider (522) is fixedly connected to the outside of the first end of the second clamping plate (532).

4. The fixing device for experimental animals according to claim 1, wherein, A first sliding groove (551) is provided at the first end of the support seat (51), and a second sliding groove (552) is provided at the second end of the support seat (51).

5. The fixing device for experimental animals according to claim 4, wherein, A third fixing slider (561) is provided at the bottom of the first sliding groove (551), and the third fixing slider (561) is fixedly connected to the first fixing slider (521) above the first sliding groove (551); At the bottom of the second sliding groove (552), there is a fourth fixed slider (562), and the fourth fixed slider (562) is fixedly connected to the second fixed slider (522) above the second sliding groove (552).

6. The fixing device for experimental animals according to claim 1, wherein Both the first connecting arm (421) and the second connecting arm (422) are fixedly connected to the support base (51) through a support plate (54).

7. The fixing device for experimental animals according to claim 1, characterized in that, A phased array ultrasound focusing device for focused ultrasound is provided in the open container.

8. A magnetic resonance examination device for experimental animals, characterized in that, Comprising: A magnetic resonance main unit (6) and the fixing device for experimental animals according to any one of claims 1 to 7, wherein the second fixing device (3), the third fixing device (4), and the fourth fixing device (5) of the fixing device for experimental animals are correspondingly arranged with the inspection cavity of the magnetic resonance main unit.

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