Plugging devices and plugging systems

Abstract

The present invention provides a closure device and a closure device, the closure device comprising: two ends, at least two supporting structures and a coating; the two ends are arranged at the two ends of the closure device along the axial direction; at least two supporting structures are arranged circumferentially around the axis of the closure device, and the two ends of at least two supporting structures respectively converge at one end; the supporting structure switches between an expanded state and a contracted state; when the supporting structure is in the expanded state, the supporting structure protrudes outward along the radial direction of the closure device; the coating is coated on the outside of at least two supporting structures and is used to contract or expand as the state of the supporting structure changes. With such a configuration, the closure device has low dependence on the doctor's skills, high treatment efficiency, simple operation, low surgical cost, no need for long-term dual-antibody administration, and can also achieve non-directional closure, and can treat apical aneurysms and sidewall aneurysms.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a blocking device and a blocking system. Background Art

[0002] Intracranial aneurysms are pathological protrusions of the intracranial artery wall. The fundamental treatment for intracranial aneurysms is to completely isolate the aneurysm from the blood circulation through therapeutic means. Currently, the main treatment method is endovascular interventional therapy, which mainly includes the following:

[0003] (1) Aneurysm endoembolization coil therapy is currently the main method for treating aneurysms. Its treatment principle is to change local hemodynamic factors, promote thrombosis, and then achieve aneurysm occlusion and treatment. However, aneurysms vary in morphology. Incomplete coil packing can lead to aneurysm recanalization, while excessive packing can lead to low embolization efficiency and may even cause aneurysm rupture. Moreover, these require the doctor's long-term skills and experience accumulation. Furthermore, coil packing requires repeated packing, which is complicated and expensive to operate. It is easy to herniate the aneurysm when used alone.

[0004] (2) As a breakthrough in the treatment of intracranial aneurysm vessels, the blood flow guide device has brought a new method to the treatment of complex aneurysms. Its treatment principle is to place a dense mesh stent in the parent artery, reconstruct the lumen of the diseased blood vessel, and then reshape the inner surface of the blood vessel lumen through the new vascular endothelium on the surface of the aneurysm neck. The application of the blood flow guide device has significantly improved the long-term efficacy of large and giant aneurysms and greatly reduced the use of spring coils. Computer hemodynamic simulation analysis shows that when the metal coverage rate reaches 30% to 50%, the blood flow in the aneurysm cavity can be significantly reduced. However, the use of the blood flow guide device makes patients rely on dual antiplatelet therapy for a long time, and there is a risk of hemorrhagic complications after surgery. In addition, there is a certain risk of delayed rupture after treating some large aneurysms.

[0005] (3) There are also some occlusion systems, which are usually made of shape memory materials and pre-shaped. They are delivered through a catheter and pushed out of the sheath after reaching a specific position. They expand and recover to the pre-shaped shape by themselves, thereby achieving the purpose of occluding the aneurysm. Its main principle is similar to that of the blood flow guide device, which is to achieve the reconstruction of the inner surface of the blood vessel cavity by blocking the blood flow. However, in these occlusion systems, due to the different sizes of the metal mesh, the blood flow blocking at the neck of the aneurysm is directional, and the proximal structure will herniate into the aneurysm-bearing artery. The occlusion position needs to be adjusted and placed repeatedly. It is suitable for aneurysms at the bifurcation and the top aneurysm, but not for sidewall aneurysms, which affects the stability of the occlusion system in the aneurysm. In addition, the distal structure is relatively sharp, which will bring a greater impact to the weak aneurysm top. The protruding structure at the proximal end will also herniate into the aneurysm-bearing artery due to the squeezing of the aneurysm wall, interfering with blood flow and affecting the endothelialization process of the aneurysm neck. In addition, the internal cavity of this type of occlusion system is usually large, and its stability is affected by the water hammer of blood. The internal cavity has little resistance to the blood flow in the aneurysm, which is not conducive to the formation of thrombus in the aneurysm.

[0006] Therefore, it is necessary to develop a new blocking device to solve at least the above problems. Summary of the Invention

[0007] The purpose of the present invention is to provide a closure device and a closure system to solve the problems of low efficiency in current aneurysm treatment, strong dependence on doctor's skills, complex operation, high cost, long-term dual-antibody administration required for patients, directional blood flow obstruction, and unsuitability for treating side wall aneurysms.

[0008] In order to solve the above technical problems, the present invention provides a sealing device and a sealing device, comprising: two ends, at least two supporting structures and a coating; the two ends are arranged at the two ends of the sealing device along the axial direction; at least two supporting structures are arranged circumferentially around the axis of the sealing device, and the two ends of at least two supporting structures converge at one end respectively; the supporting structure switches between an expanded state and a contracted state; when the supporting structure is in the expanded state, the supporting structure protrudes outward in the radial direction of the sealing device; the coating is covered on the outside of at least two supporting structures, and is used to shrink or stretch as the state of the supporting structure changes.

[0009] Optionally, the single support structure includes at least one support wire, and at least one support wire is woven into a shape.

[0010] Optionally, a single support structure includes at least two support filaments, and at least two support filaments in the single support structure are twisted with each other.

[0011] Optionally, at least two supporting filaments of a single supporting structure are twisted evenly.

[0012] Optionally, the support wire of a single support structure forms at least one closed loop structure.

[0013] Optionally, the two ends respectively include a first developing component and a second developing component; the first developing component is a sheet-like structure, the sheet-like structure includes at least two holes, the distal end of each supporting structure is respectively connected to the first developing component; the proximal end of the supporting structure is connected to the second developing component.

[0014] Optionally, a single support structure includes at least two support wires, and at least two support wires in a single support structure are twisted with each other. The sheet structure includes an even number of holes, and the support wires are respectively passed through two holes arranged diagonally. Adjacent non-same-root support wires are twisted and fixed so that at least one closed loop is formed between the non-same-root support wires.

[0015] Optionally, the maximum dimension of the closed loop along the axial direction of the blocking device is not less than half of the maximum dimension of the supporting structure along the axial direction of the blocking device.

[0016] Optionally, when the at least two supporting structures are in an expanded state, the second developing component is recessed toward the interior of the at least two supporting structures, so that a recessed depth of the second developing component is not less than an axial length of the second developing component along the axial direction of the blocking device.

[0017] Optionally, the coating has a porous structure, and the pores of the porous structure are evenly distributed.

[0018] Optionally, the coating is sewn, dip-molded or electrostatically spun on the at least two supporting structures.

[0019] In order to solve the above technical problems, the present invention also provides a blocking system, comprising: the blocking device, sheath and push-pull device as described above; the blocking device can be movably inserted into the sheath; the push-pull device is connected to the proximal end of the blocking device, and the push-pull device is used to move the position of the blocking device relative to the sheath; when the blocking device is inside the sheath, the blocking device is in a telescopic state; when the blocking device is outside the sheath, the blocking device is in an expanded state.

[0020] The present invention provides a closure device and a closure device, wherein the closure device includes: two ends, at least two supporting structures, and a coating; the two ends are arranged at the two ends of the closure device along the axial direction; at least two supporting structures are arranged circumferentially around the axis of the closure device, and the two ends of at least two supporting structures converge at one end; the supporting structure switches between an expanded state and a contracted state; when the supporting structure is in the expanded state, the supporting structure protrudes radially outward along the closure device; the coating is wrapped around the outside of at least two supporting structures and is used to contract or expand as the state of the supporting structure changes. This arrangement makes the closure device less dependent on the doctor's skills, has high treatment efficiency, is simple to operate, has low surgical costs, does not require long-term use of dual antibodies, and can also achieve non-directional closure, and can treat apical aneurysms and sidewall aneurysms. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Those skilled in the art will appreciate that the accompanying drawings are provided for a better understanding of the present invention and do not constitute any limitation on the scope of the present invention.

[0022] Figure 1 This is a top view of the occlusion device according to embodiment 1 of the present invention in an expanded state.

[0023] Figure 2 This is a front view of the occlusion device according to the first embodiment of the present invention in an expanded state.

[0024] Figure 3 This is a schematic diagram of the blocking device in the contracted state according to the first embodiment of the present invention.

[0025] Figure 4 This is a top view of the occluding device according to the second embodiment of the present invention in an expanded state.

[0026] Figure 5 This is a front view of the occlusion device according to the second embodiment of the present invention in an expanded state.

[0027] Figure 6 This is a top view of the blocking device according to embodiment 3 of the present invention in an expanded state.

[0028] Figure 7 This is a front view of the occlusion device according to the third embodiment of the present invention in an expanded state.

[0029] Figure 8 Schematic diagram of the first developing component of embodiment 3 of the present invention.

[0030] In the attached figure:

[0031] A- push-pull device;

[0032] B-sheath;

[0033] 100 - end portion, 110 - first developing component, 111 - hole, 120 - second developing component;

[0034] 200-support structure, 210-support wire, 211-first support wire, 212-second support wire, 213-third support wire;

[0035] 300-Lamination. DETAILED DESCRIPTION

[0036] To make the objects, advantages, and features of the present invention more clearly apparent, the present invention is further described below in conjunction with the accompanying drawings and specific embodiments. It should be noted that the drawings are all in a very simplified form and are not drawn to scale. They are only used to conveniently and clearly assist in illustrating the purposes of the embodiments of the present invention. In addition, the structures shown in the drawings are often part of the actual structure. In particular, different drawings may need to illustrate different focuses and sometimes use different scales.

[0037] As used in this specification, the singular forms "a," "an," and "the" include plural referents unless the context clearly indicates otherwise. As used in this specification, the term "or" is generally used to include "and / or," unless the context clearly indicates otherwise. The term "several" is generally used to include "at least one," and the term "at least two" is generally used to include "two or more." Furthermore, the terms "first," "second," and "third" are used for descriptive purposes only and should not be construed to indicate or imply relative importance or implicitly specify the number of the technical features identified. Thus, features defined as "first," "second," and "third" may explicitly or implicitly include one or at least two of such features. The terms "mounted," "connected," and "connected" should be broadly construed, meaning, for example, fixedly connected, removably connected, or integrally connected; directly connected or indirectly connected through an intermediary; and may refer to internal communication between two components or an interaction between two components. The term "distal end" refers to the end away from the medical staff's manipulation, and the term "proximal end" refers to the end closer to the medical staff's manipulation. In addition, as used in the present invention, an element is arranged on another element, which generally only indicates that there is a connection, coupling, cooperation or transmission relationship between the two elements, and the connection, coupling, cooperation or transmission between the two elements can be direct or indirect through an intermediate element, and cannot be understood as indicating or implying the spatial position relationship between the two elements, that is, an element can be in any orientation such as the inside, outside, above, below or one side of another element, unless the content clearly indicates otherwise. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances. In addition, in the following description, a large number of specific details are given in order to provide a more thorough understanding of the present invention. However, it is obvious to those skilled in the art that the present invention can be implemented without one or more of these details. In other examples, in order to avoid confusion with the present invention, some technical features well known in the art are not described.

[0038] An embodiment of the present invention provides a closure device and a closure device, the closure device comprising: two ends, at least two supporting structures and a coating; the two ends are arranged at the two ends of the closure device along the axial direction; at least two supporting structures are arranged circumferentially around the axis of the closure device, and the two ends of at least two supporting structures respectively converge at one end; the supporting structure switches between an expanded state and a contracted state; when the supporting structure is in the expanded state, the supporting structure protrudes outward along the radial direction of the closure device; the coating is coated on the outside of at least two supporting structures and is used to contract or expand as the state of the supporting structure changes. With such a configuration, the closure device has low dependence on the doctor's skills, high treatment efficiency, simple operation, low surgical cost, no need for long-term dual-antibody administration, and can also achieve non-directional closure, and can treat apical aneurysms and sidewall aneurysms.

[0039] The following description is given with reference to the accompanying drawings.

[0040] [Example 1]

[0041] Figure 1 This is a top view of the occlusion device according to embodiment 1 of the present invention in an expanded state. Figure 2 This is a front view of the occlusion device according to the first embodiment of the present invention in an expanded state. Figure 3 This is a schematic diagram of the blocking device in the contracted state according to the first embodiment of the present invention.

[0042] Please refer to Figures 1 to 3 The occlusion device provided in the first embodiment can be used for aneurysms, for example, for treating intracranial saccular aneurysms. The occlusion device includes two end portions 100, at least two support structures 200, and a coating 300.

[0043] like Figure 2As shown, the two ends 100 are arranged at the two ends of the occluding device along the axial direction. The two ends 100 can be, for example, the proximal end and the distal end of the occluding device. At least two of the support structures 200 are arranged circumferentially around the axis of the occluding device, and the two ends of at least two of the support structures 200 respectively converge at one of the ends. For example, the distal ends of at least two of the support structures 200 converge at the distal end, and the proximal ends of at least two of the support structures 200 converge at the proximal end, thereby making the at least two circumferentially arranged support structures 200 present a fusiform skeleton. Compared with the currently used spring coil structure, this structure has low dependence on the doctor's technology and is relatively simple to operate, thereby improving treatment efficiency and reducing surgical costs. It is understandable that the axial direction and axis of the occluding device are the directions in the same direction as the axial direction of the blood vessel when the occluding device is loaded into the blood vessel. Preferably, the two support structures 200 can be symmetrically arranged along the axis, so that the skeleton of the support structure 200 can be symmetrical, with the metal coverage rate being the same at all locations. This simplifies the packing process, eliminates the need for excessive position adjustments, and improves the sealing efficiency. Preferably, the number of support structures 200 can be between 3 and 8, thereby ensuring the supporting force of the support skeleton formed by the support structures 200.

[0044] like Figure 1 and Figure 3 As shown, the support structure 200 switches between an expanded state and a contracted state. When the support structure 200 is in the expanded state, the support structure 200 protrudes radially outward along the occlusion device. Preferably, the radially protruding dimension of the support structure 200 is not greater than half of the distance between the proximal end and the distal end, thereby making the support structure 200 have a higher occlusion efficiency and less damage to the blood vessel. More preferably, the radially protruding dimension of the support structure 200 is equal to half of the distance between the proximal end and the distal end, thereby making the support structure 200 a spherical skeleton. Compared with the fusiform skeleton, the support structure 200 with a spherical skeleton is smaller in size, the spherical structure is round, has no orientation, has a higher occlusion efficiency, and causes less damage to the blood vessel.

[0045] like Figures 1 to 3As shown, the coating 300 is coated on the outside of at least two of the support structures 200 and is used to shrink or stretch as the state of the support structure 200 changes. Specifically, when the support structure 200 is in an expanded state, the coating 300 is stretched, and when the support structure 200 is in an expanded state, the coating 300 is contracted, so that when the support structure 200 is in an expanded state, the setting of the support structure 200 and the coating 300 of the occlusion device achieves intra-tumor support, so that the coating 300 can block blood flow and prevent blood flow from entering the aneurysm, thereby achieving the purpose of treating the aneurysm. In this way, the occlusion device does not need to enter the tumor-bearing artery, avoids the use of a blood flow diversion device, and thus does not need to rely on dual antiplatelet therapy for a long time, and does not need to take dual antiplatelet therapy for a long time. Moreover, unlike the currently used occlusion system due to the setting of the metal grid, the coating 300 can achieve non-directional occlusion and is suitable for the treatment of apical aneurysms and sidewall aneurysms. The setting of the coating 300 can also provide a scaffolding structure for cell growth, thereby achieving the treatment of aneurysms. The coating 300 is preferably a porous structure, for example. More preferably, it is a porous membrane, for example. More preferably, the coating 300 is a micro-nano composite porous membrane, for example. The coating 300 is made of expanded polytetrafluoroethylene (ePTFE), polyethylene terephthalate (PET) non-woven membrane, polyurethane (PU), polycaprolactone (PCL) or (lactide-ε-caprolactone) copolymer (PLC). In this embodiment, the coating 300 is made of expanded polytetrafluoroethylene (ePTFE). The porosity of the porous structure of the coating 300 is between 50% and 80%, and the pore diameter is dispersed between 50nm and 500μm. The thickness of the porous membrane can be selected between 5μm and 100μm. Those skilled in the art can adjust the pore size and density of the coating 300 according to actual needs, so that it can block blood flow while providing a scaffold for cell growth and promote aneurysm healing.

[0046] Preferably, a single support structure 200 includes at least one support wire 210, and at least one support wire 210 is woven. For example, the support structure 200 includes at least one support wire 210, and one support wire 210 is woven by bending or twisting its own filamentary structure to form the support structure 200. The support structure 200 may also include two or more support wires 210, and the two or more support wires 210 are woven together to form the support structure 200.

[0047] Further, such as Figures 1 to 3As shown, the two end portions 100 respectively include a first developing component 110 and a second developing component 120. The first developing component 110 is, for example, located at the distal end of the occluding device, and the second developing component 120 is, for example, located at the proximal end of the occluding device. The first developing component 110 and the second developing component 120 perform a developing function. The first developing component 110 is a sheet-like structure including at least two holes 111. The distal end of each support structure 200 is connected to the first developing component 110. The sheet-like structure can be square, circular, triangular, trapezoidal, or polygonal. Compared to a sharp distal end, the sheet-like structure is more adaptable to fragile blood vessels and aneurysms, thereby making the occluding device isotropic in all directions, reducing the impact of the distal rivet point on the aneurysm, and enabling the occluding device to be used to fill apical bifurcation aneurysms and sidewall aneurysms. More preferably, the sheet structure can be arranged in a petal shape, which makes the sheet structure all curved, thereby making the structure more suitable for fragile blood vessels and aneurysms. Figure 2 and Figure 3 As shown, the arrangement of the sheet-like structure makes the occlusion device more gentle on the blood vessels and the top of the aneurysm, avoiding the distal end from impacting the weak top of the aneurysm. The sheet-like structure includes a hole 111, which is used for connecting and fixing the support structure 200. Specifically, the support structure 200 includes, for example, a support wire 210, and one of the support wires 210 is inserted into one of the holes 111, thereby providing the support wire 210 with a fixed base point. The proximal end of the support structure 200 is connected to the second developing component 120, so that the proximal end of the support structure 200 can be restrained and fixed by the second developing component 120. The second developing component 120 is, for example, a circular ring, and the support structure 200 is connected to the circular ring. Specifically, the support structure 200 includes at least one support wire 210, and each of the support wires 210 is connected to the circular ring. Preferably, the support structure 200 and the second developing component 120 are fixedly connected. Of course, the number of the holes 111 of the first developing component 110 can be multiple, such as 3, 4 or 5, etc. Preferably, the number of the holes 111 can be any number from 3 to 8. Figure 1As shown, in the first embodiment, the number of the holes 111 is preferably 4, and the sheet structure has four vertices, and each of the four vertices includes a hole 111. More preferably, in the first embodiment, the number of the holes 111 is preferably consistent with the number of the supporting structures 200, and one supporting structure 200 corresponds to one hole 111. Of course, in other embodiments, the number of the holes 111 and the supporting structures 200 may not correspond, for example, two holes 111 are respectively provided for one supporting structure 200, etc. Those skilled in the art can set the number of holes 111 according to actual conditions, and select the quantitative relationship between the holes 111 and the supporting structures 200 according to actual conditions. The shape of the hole 111 can be a circular hole, a triangular hole, a square hole, etc. Those skilled in the art can make a selection according to actual conditions, and this document does not limit it here.

[0048] Further, such as Figure 2 As shown, when the at least two support structures 200 are in an expanded state, the second developing component 120 is recessed toward the interior of the at least two support structures 200, ensuring that the recessed depth of the second developing component 120 is no less than the axial length of the second developing component 120 along the occlusion device. This prevents the second developing component 120 from protruding beyond the framework of the support structures 200, preventing the proximal end of the occlusion device from herniating into the parent artery due to compression from the aneurysm wall, disrupting blood flow, and thus preventing the endothelialization process of the aneurysm neck from being affected. Furthermore, the recessed configuration of the second developing component 120 renders the occlusion device non-orientable, shortening the surgeon's surgical time and improving both surgical and treatment efficiency.

[0049] Preferably, Figure 1As shown, a single support structure 200 includes at least two support filaments 210, and at least two support filaments 210 in a single support structure 200 are twisted with each other. In this first embodiment, the blocking device includes four support structures 200, and the sheet-like structure of the first developing filament 110 includes four holes 111, with each support structure 200 corresponding to one hole 111. Each support structure 200 includes two support filaments 210, each connected to a corresponding hole 111. The two support filaments 210 are twisted with each other to form a structure that mutually reinforces the rigidity of the support filaments 210, ensuring the strength of the support structure 200 and increasing the supporting force of the support structure 200. It is understood that the twisting means that at least two support filaments 210 can be intertwined with each other, and the force conditions between the at least two support filaments 210 are similar. For example, the two support filaments 210 are twisted together, and the force acting on the two support filaments 210 is the same. It should be understood that the twisting between the two support wires 210 can be tightly wound around each other, and the gap between the two support wires 210 is small to ensure the rigidity of the support structure 210; there can also be gaps between the winding gaps of the two support wires 210. Such an arrangement increases the metal coverage rate on the support skeleton of the support structure 210 and improves the skeleton support force. Of course, in other embodiments, those skilled in the art can, according to actual conditions, make a single support structure 200 include one support wire 210. Preferably, the wire diameter of each support wire 210 can be between 0.0005 and 0.003 inches, so that the support wire 210 has a thinner wire diameter, so that the support structure 210 is smaller in size, so that it can enter a thinner sheath B, and can enter a thinner blood vessel. Preferably, the material of the support wire 210 can be a metal with shape memory function, such as nickel titanium (Ni-Ti) alloy, nickel titanium cobalt alloy (Ni-Ti-Co), etc.; a polymer material with a certain shape recovery ability can also be selected, such as polydioxanone (PDO), (lactide-ε-caprolactone) copolymer (PLC), polyurethane (PU), polynorbornene amorphous polymer, etc.

[0050] Preferably, at least two of the support wires 210 of a single support structure 200 are evenly twisted, that is, at least two of the support wires 210 are evenly wound, and the winding angle between each support wire 210, the gap formed by the winding of each support wire 210, and the number of windings are all the same, ensuring that the force between each support wire 210 is uniform and the supporting force of the support structure 200 is the same. Of course, two of the support wires 210 of the support structure 200 are evenly twisted, or all of the support wires 210 are evenly twisted. The occluding device provided in this embodiment 1 uses a smaller number of support wires 210 to complete the establishment of the support skeleton, so that the occluding device can reach more lesion locations through a smaller sheath B.

[0051] Furthermore, the membrane 300 has a porous structure with uniformly distributed pores, enabling it to uniformly block blood flow, ensuring the occlusion device is non-oriented within the aneurysm and achieving high occlusion efficiency. Furthermore, while blocking blood flow, the porous membrane 300 also provides a scaffold for cell growth and climbing, promoting aneurysm healing.

[0052] Preferably, the coating 300 is sewn, dip-molded, or electrospun onto the at least two support structures 200. In the first embodiment, the coating 300 is fixed to the support structure 200 by stitching, and the coating 300 is fixed to the distal end, proximal end, and middle portion of the support structure 200. Specifically, the coating 300 is fixed to the first developing component 110, the second developing component 120, and the middle portion of the support structure 200. In other embodiments, the coating 300 can be directly dipped into the support structure 200, or the coating 300 can be electrospun onto the support structure 200.

[0053] This embodiment 1 also provides a blocking system, which includes a blocking device, a sheath B and a push-pull device A. The blocking device can be movably inserted into the sheath B. The push-pull device A is connected to the proximal end of the blocking device, and the push-pull device A is used to move the position of the blocking device relative to the sheath B. After the push-pull device A pushes the blocking device to the target position outside the sheath B, the push-pull device A is released from the blocking device, and the blocking device expands. Preferably, one end of the proximal end of the blocking device is connected to the push-pull device A, and the proximal end includes, for example, a second developing component 120, and the second developing component 120 is connected to the push-pull device A. The blocking device can grasp the position of its proximal end through the developing mark of the second developing component 120. More preferably, the proximal end of the supporting structure 200 of the blocking device is connected to the second developing component 120, so that the push-pull device A, the second developing component 120 and the supporting structure 200 can be fixedly connected together. Of course, those skilled in the art can make settings according to actual needs. For example Figure 3 As shown, when the pushing device A makes the blocking device inside the sheath B, the blocking device is in a telescopic state. When the blocking device is in the telescopic state, the support structure 200 is compressed into a bundle, thereby providing conditions for pushing. When the pushing device A pushes the blocking device so that the blocking device is outside the sheath B, the blocking device is in an expanded state. It should be understood that Figure 3 As shown, the pushing device can push the occlusion device out of the sheath B to the location of the aneurysm. If the occlusion device is not directly positioned at the aneurysm, the occlusion device can be pulled back so that it can be repeatedly positioned at the aneurysm, thereby improving treatment efficiency. The occlusion system has the beneficial effects brought by the occlusion device, which will not be described in detail here. The other structures and principles of the occlusion system can be referred to the existing technology and will not be described in detail here.

[0054] [Example 2]

[0055] Figure 4 This is a top view of the occlusion device according to the second embodiment of the present invention in an expanded state; Figure 5 This is a front view of the occlusion device according to the second embodiment of the present invention in an expanded state.

[0056] The same parts of the blocking device of the second embodiment as those of the first embodiment will not be described in detail, and only the differences will be described below.

[0057] like Figures 4 and 5As shown, the support wires 210 of a single support structure 200 form at least one closed-loop structure. In the second embodiment, each support structure 200 includes two support wires 210, and two closed-loop structures are formed between the two support wires 210. The two closed-loop structures are separated by the entanglement knot between the two support wires 210 to improve the metal coverage on the occlusion device, that is, to improve the skeleton support force of the support skeleton formed by the support structure 200. Of course, in other embodiments, a closed-loop structure can be formed between the support wires 210 of a single support structure 200, or three closed-loop structures can be formed between the support wires 210. The sizes of the single closed-loop structures can be the same or different. Those skilled in the art can set the number of closed loops and the relative size of each closed loop according to actual needs.

[0058] Preferably, the coating 300 is a polyurethane film, which is directly formed on the surface of the support structure 200 by electrostatic spraying and is bonded to the skeleton of the support structure 200, thereby improving the production efficiency of the blocking device.

[0059] [Example 3]

[0060] Figure 6 This is a top view of the occlusion device in the expanded state according to the third embodiment of the present invention; Figure 7 This is a front view of the occlusion device in the expanded state according to the third embodiment of the present invention; Figure 8 Schematic diagram of the first developing component of embodiment 3 of the present invention.

[0061] The same parts between the blocking device of the third embodiment and the first and second embodiments will not be described again, and the following will focus on the differences.

[0062] like Figures 6 and 7 As shown, the sheet structure of the first developing component 110 includes an even number of holes 111, and the supporting wires 210 are respectively passed through two holes 111 arranged diagonally. The adjacent supporting wires 210 of different roots are twisted and fixed, so that at least one closed loop is formed between the supporting wires 210 of different roots. Figure 8As shown, in this third embodiment, the sheet structure has six holes 111 and three support structures 200. Each support structure 200 includes a support wire 210. The three support wires 210 are a first support wire 211, a second support wire 212, and a third support wire 213. The first support wire 211 is inserted through two diagonally arranged holes 111 from top to bottom and then from bottom to top. The support wires 210 on either side of the two diagonally arranged holes 111 are of equal length. Next, the second support wire 212 is inserted through two adjacent diagonally symmetrical holes 111 in the same manner. Finally, the third support wire 213 is inserted through two adjacent diagonally symmetrical holes 111 in the same manner, thereby forming six support wires 210, each with a free end. Adjacent, non-identical support wires 210 are then twisted and secured in pairs for one twist. A large closed loop is then formed and tightly twisted for another two to four twists before being secured by the second developing unit 120. Such an arrangement allows the metal coverage of the support structure 200 to be higher, further enhancing the supporting force of the support frame.

[0063] Preferably, the maximum dimension of the closed loop along the axial direction of the blocking device is not less than half of the maximum dimension of the support structure 200 along the axial direction of the blocking device, thereby ensuring the metal coverage while ensuring the rigidity and flexibility of the support structure 200.

[0064] Optionally, after the closed loop is tightly twisted for 2 to 4 turns, another closed loop is wound, and then tightly twisted for 1 turn before being bound and fixed by the second developing unit 120. The maximum diameter of the second closed loop is no greater than the maximum diameter of the first closed loop, and both are less than 1 / 2 of the radial dimension of the support structure 200. Of course, those skilled in the art can set the number of closed loops according to actual needs, such as three or four.

[0065] More preferably, the coating 300 is a polyurethane film, which is directly formed on the support structure 200 by a dipping method and is bonded to the support structure 200 at the same time, ensuring that the coating 300 can be tightly connected to the support structure 200.

[0066] Of course, the different twisting and closed loop formation situations in the first, second and third embodiments can be used in combination. For example, the two supporting wires 210 of a supporting structure 200 used in the first embodiment are twisted evenly, and the two supporting wires 210 of a supporting structure 200 in the second embodiment form two closed loop structures. In other embodiments, a supporting structure 200 in the first embodiment can be combined with a supporting structure 200 in the second embodiment to form a supporting skeleton, thereby improving the skeleton support force of the occlusion device. For another example, in the third embodiment, the supporting wires 210 of different supporting structures 200 are twisted with each other to form a closed loop structure. In other embodiments, a supporting structure 200 in the first embodiment can be combined with two supporting structures 200 in the third embodiment to form a supporting skeleton. It is also possible to combine two supporting structures 200 in the second embodiment with two supporting structures 200 in the third embodiment to form a supporting skeleton. Of course, in other embodiments, the number of the supporting structures 200 can be set according to actual needs, and this document does not limit it here.

[0067] In summary, the present invention provides a closure device and a closure system, wherein the closure device includes: two ends, at least two supporting structures, and a coating; the two ends are arranged at the two ends of the closure device along the axial direction; at least two supporting structures are arranged circumferentially around the axis of the closure device, and the two ends of at least two supporting structures converge at one end respectively; the supporting structure switches between an expanded state and a contracted state; when the supporting structure is in the expanded state, the supporting structure protrudes outward along the radial direction of the closure device; the coating is wrapped around the outside of at least two supporting structures and is used to contract or expand as the state of the supporting structure changes. This arrangement makes the closure device less dependent on the doctor's skills, has high treatment efficiency, is simple to operate, has low surgical costs, does not require long-term use of dual antibodies, and can also achieve non-directional closure, and can treat apical aneurysms and sidewall aneurysms.

[0068] It should be noted that the embodiments in this specification focus on the differences from other embodiments, and the same or similar parts between the embodiments can be referenced to each other.

[0069] Furthermore, it should be recognized that although the present invention has been disclosed above with reference to preferred embodiments, the above embodiments are not intended to limit the present invention. Any person skilled in the art can utilize the above disclosed technical content to make many possible changes and modifications to the technical solution of the present invention, or modify it into equivalent embodiments with equivalent variations, without departing from the scope of the technical solution of the present invention. Therefore, any simple modifications, equivalent variations, and modifications made to the above embodiments based on the technical essence of the present invention, without departing from the content of the technical solution of the present invention, shall still fall within the scope of protection of the technical solution of the present invention.

Claims

1. A closure device for treating aneurysms, characterized in that: include: two ends, at least two support structures, and a covering membrane; The two end portions are arranged at two ends of the blocking device along the axial direction; At least two of the support structures are circumferentially arranged around the axis of the occlusion device, and both ends of the at least two support structures converge at one end portion respectively; The support structure switches between an expanded state and a contracted state; when the support structure is in the expanded state, the support structure bulges outward in the radial direction of the occluding device, and the dimension of the radial bulge is no greater than half the distance between the proximal end and the distal end of the occluding device; The covering film is coated on at least two of the supporting structures and is used to shrink or expand as the state of the supporting structure changes; The two end portions respectively include a first developing component and a second developing component; the first developing component is a sheet-like structure, the distal end of each supporting structure is respectively connected to the first developing component, and the proximal end of the supporting structure is connected to the second developing component; a single supporting structure includes at least two supporting wires, and at least two supporting wires in a single supporting structure are twisted with each other, and the sheet-like structure includes an even number of holes, and the supporting wires are respectively passed through two holes arranged diagonally, and the adjacent non-same-root supporting wires are twisted and fixed so that at least one closed loop is formed between the non-same-root supporting wires.

2. The blocking device according to claim 1, characterized in that: At least two support filaments of a single support structure are twisted evenly.

3. The blocking device according to claim 2, characterized in that: The support wire of a single support structure forms at least one closed loop structure.

4. The blocking device according to claim 1, characterized in that: The maximum dimension of the closed loop along the axial direction of the blocking device is not less than half of the maximum dimension of the supporting structure along the axial direction of the blocking device.

5. The blocking device according to claim 1, wherein: When at least two of the supporting structures are in an expanded state, the second developing component is recessed toward the interior of the at least two supporting structures, so that a recessed depth of the second developing component is not less than an axial length of the second developing component along the axial direction of the blocking device.

6. The blocking device according to claim 1, characterized in that: The coating has a porous structure, and the pores of the porous structure are evenly distributed.

7. The blocking device according to claim 1, characterized in that: The coating is sewn, dip-molded or electrostatically spun on the at least two supporting structures.

8. A blocking system, characterized in that: include: The occlusion device, sheath, and push-pull device according to any one of claims 1 to 7; The blocking device can be movably inserted into the sheath; The push-pull device is connected to the proximal end of the blocking device, and is used to move the blocking device relative to the sheath; When the blocking device is inside the sheath, the blocking device is in a telescopic state; when the blocking device is outside the sheath, the blocking device is in an expanded state.

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