Correction Test Initiation Method, Control Device, and Coagulation Analyzer

Abstract

An embodiment of the present invention provides a correction test start method, a control device, and a coagulation analyzer, belonging to the field of medical devices. The method includes: obtaining correction test application information configured by a user, where the correction test application information includes a target coagulation index item, a correction test plan, and the position of a first sample tube; controlling a sampling mechanism to aspirate a blood sample to be tested in the sample tube corresponding to the position of the first sample tube into a reaction cup, and according to the correction test plan, using a standard mixed blood sample in a sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup. The technical solution of the embodiment of the present invention greatly improves the execution efficiency and accuracy of the correction test.

Description

Technical Field

[0001] The present invention relates to the field of medical devices, and in particular to a correction test starting method, a control device and a coagulation analyzer. Background Art

[0002] The coagulation analyzer can perform coagulation analysis on the patient's blood sample and output the coagulation analysis results. The coagulation analysis results may include the values ​​of coagulation index items such as prothrombin time (Prothrombin Time, PT), thrombin time (Thrombin Time, TT), activated partial thromboplastin time (Activated Partial Thromboplastin Time, APTT) of the patient's blood sample. In some cases, it is necessary to perform correction tests on the coagulation index items of the patient's blood sample.

[0003] At present, before the correction test of the coagulation index items of the patient's blood sample is carried out, the inspector needs to manually prepare the standard mixed blood sample, and also needs to manually incubate the blood sample. After the correction test is completed, the inspector needs to manually calculate the test results. The entire correction test process is complicated and takes a long time. Moreover, the entire correction test process is completed manually, and the accuracy of the correction test results cannot be guaranteed. Therefore, how to improve the execution efficiency and accuracy of the correction test is an urgent problem to be solved. Summary of the invention

[0004] The embodiments of the present invention provide a corrective test initiation method, a control device and a coagulation analyzer, aiming to improve the execution efficiency and accuracy of the corrective test.

[0005] In a first aspect, an embodiment of the present invention provides a correction test initiation method based on a coagulation analyzer, wherein the coagulation analyzer includes a sample suction mechanism, a placement mechanism, and one or more sample pools, wherein the placement mechanism is used to place a reaction cup, and the sample pool is used to prepare and hold a standard mixed blood sample, and the method includes:

[0006] Acquiring correction test application information configured by a user, wherein the correction test application information includes a target coagulation index item, a correction test scheme, and a first sample tube position;

[0007] The sample aspirating mechanism is controlled to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and a correction test is performed on the blood sample to be tested in the reaction cup according to the correction test scheme using the standard mixed blood sample in the sample pool corresponding to the target coagulation index item.

[0008] The correction test initiation method provided by the embodiments of the present invention enables a user to configure correction test application information when a correction test is required. In this way, the coagulation analyzer can perform a correction test according to the correction test application information. Moreover, the coagulation analyzer uses the standard mixed blood sample in the sample pool to perform a correction test on the blood sample to be tested according to the correction test plan in the correction test application information, eliminating the need for the user to manually prepare the standard mixed blood sample. Additionally, the entire process of the correction test does not require manual intervention and is automatically completed by the coagulation analyzer, greatly improving the execution efficiency and accuracy of the correction test.

[0009] In a second aspect, the embodiments of the present invention provide a correction test initiation method based on a coagulation analyzer. The coagulation analyzer includes a sampling mechanism, a placement mechanism, and one or more sample pools. The placement mechanism is used to place reaction cups, and the sample pools are used to prepare and store standard mixed blood samples. The coagulation analyzer includes a first correction test mode and a second correction test mode. In the first correction test mode, the coagulation analyzer uses the standard mixed blood sample in the sample pool to perform a correction test. In the second correction test mode, the coagulation analyzer uses the standard mixed blood sample manually prepared by the user to perform a correction test. The method includes:

[0010] Obtain the correction test application information configured by the user, where the correction test application information includes a target coagulation index item, a correction test plan, a first sample tube position, and a sample source identifier;

[0011] Control the coagulation analyzer to be in the first correction test mode or the second correction test mode according to the sample source identifier;

[0012] In the first correction test mode, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and according to the correction test plan, use the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup;

[0013] In the second correction test mode, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and according to the correction test plan, use the standard mixed blood sample in the sample tube corresponding to the second sample tube position in the correction test application information to perform a correction test on the blood sample to be tested in the reaction cup.

[0014] The correction test startup method provided by the embodiments of the present invention. Since the coagulation analyzer includes a first correction test mode and a second correction test mode, users can select to use the first correction test mode or the second correction test mode as needed. When selecting to use the first correction test mode, the coagulation analyzer uses the standard mixed blood sample in the sample pool to perform the correction test, without the need for users to manually prepare the standard mixed blood sample, and the entire process of the correction test does not require manual participation and is automatically completed by the coagulation analyzer. When selecting to use the second correction test mode, the coagulation analyzer uses the standard mixed blood sample manually prepared by the user to perform the correction test. In this way, except for the need for users to manually prepare the standard mixed blood sample, the rest of the process of the correction test does not require manual participation by users, greatly improving the execution efficiency and accuracy of the correction test.

[0015] In a third aspect, the embodiments of the present invention further provide a control device. The control device includes a processor, a memory, a computer program stored on the memory and executable by the processor, and a data bus for realizing the connection and communication between the processor and the memory. When the computer program is executed by the processor, it realizes any one of the correction test startup methods provided in the specification of the present invention.

[0016] In a fourth aspect, the embodiments of the present invention further provide a coagulation analyzer, including:

[0017] One or more sample pools for preparing and storing standard mixed blood samples;

[0018] A sampling mechanism for sucking a blood sample to be tested or a standard mixed blood sample;

[0019] A placement mechanism for placing one or more reaction cups for storing the blood sample to be tested sucked by the sampling mechanism;

[0020] A control device for realizing any one of the correction test startup methods provided in the specification of the present invention.

[0021] In a fifth aspect, the embodiments of the present invention further provide a storage medium for computer-readable storage. The storage medium stores one or more programs that can be executed by one or more processors to realize any one of the correction test startup methods provided in the specification of the present invention. Description of the Drawings

[0022] To more clearly illustrate the technical solutions of the embodiments of the present application, the following will briefly introduce the accompanying drawings required for the description of the embodiments. Obviously, the accompanying drawings in the following description are some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other accompanying drawings can also be obtained based on these drawings.

[0023] Figure 1 It is a schematic flowchart of a method for starting a correction test provided by an embodiment of the present invention;

[0024] Figure 2 It is a schematic diagram of a correction test application page in an embodiment of the present invention;

[0025] Figure 3 It is another schematic diagram of a correction test application page in an embodiment of the present invention;

[0026] Figure 4 It is a schematic diagram of a comparison chart of a coagulation analysis result and a correction test in an embodiment of the present invention;

[0027] Figure 5 It is a schematic flowchart of another method for starting a correction test provided by an embodiment of the present invention;

[0028] Figure 6 It is a schematic block diagram of the structure of a control device provided by an embodiment of the present invention. Detailed implementation manners

[0029] The following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are some, but not all, of the embodiments of the present invention. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present invention without creative efforts fall within the scope of protection of the present invention.

[0030] The flowchart shown in the accompanying drawings is only an example illustration, and does not necessarily include all contents and operations / steps, nor does it necessarily need to be executed in the described order. For example, some operations / steps can also be decomposed, combined, or partially merged, so the actual execution order may be changed according to the actual situation.

[0031] It should be understood that the terms used in this specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. As used in this specification of the present invention and the appended claims, unless the context clearly indicates otherwise, the singular forms "a", "an", and "the" are intended to include the plural forms.

[0032] The following will describe in detail some embodiments of the present invention with reference to the accompanying drawings. Without conflict, the following embodiments and the features in the embodiments can be combined with each other.

[0033] Please refer to Figure 1 , Figure 1 which is a flowchart of a method for starting a correction test provided by an embodiment of the present invention. This method for starting a correction test can be applied to a coagulation analyzer to improve the execution efficiency and accuracy of the correction test.

[0034] As Figure 1 shown, this method for starting a correction test includes steps S101 to S102.

[0035] Step S101: Obtain the correction test application information configured by the user.

[0036] In an embodiment of the present invention, the blood sample to be tested includes but is not limited to a plasma sample to be tested or a whole blood sample to be tested. The correction test application information includes a target coagulation index item, a correction test plan, and the position of the first sample tube. The target coagulation index item is the coagulation index item that the user sets to perform a correction test, and the target coagulation index item may include PT, TT, and / or APTT. The correction test plan includes a correction test type and a mixing ratio, or the correction test plan includes a correction test type, a mixing ratio, and a sample incubation time. The correction test type includes a first correction test type or a second correction test type. The first correction test type corresponds to an immediate correction test, and the second correction test type corresponds to a delayed (incubation) correction test. The mixing ratio is the ratio of the blood sample to be tested to the standard mixed blood sample, and the sample incubation time is the time for incubating the sample.

[0037] In one embodiment, the correction test application information may include a sample tube rack number, the position of the first sample tube, and patient information. The position of the first sample tube is the position of the sample tube containing the blood sample to be tested on the sample tube rack, and the patient information includes age, gender, and name. Or, the correction test application information may include a sample tube rack number, the position of the first sample tube, the position of the second sample tube, and patient information. The position of the second sample tube is the position of the sample tube containing the standard mixed blood sample on the sample tube rack.

[0038] In one embodiment, the control display device displays a correction test application page and obtains the correction test application information configured by the user on the correction test application page; in response to the user's trigger operation on the save icon on the correction test application page, the correction test application information configured by the user is saved. Among them, the correction test application page may include a correction item selection box, a sample source selection box, a sample test selection box, a sample rack number input box, a sample number input box, a correction test plan input box, and a patient information input box. The user can select the coagulation index item that needs to be corrected through the correction item selection box. The user can select the source of the standard mixed blood sample for the correction test through the sample source selection box. The user can select the analysis strategy of the standard mixed blood sample through the sample test selection box. The user can input the sample rack number through the sample rack number input box. The user can input the correction test plan through the correction test plan input box. The user can input the patient information of the blood sample to be tested through the patient information input box.

[0039] For example, as Figure 2 shown, the correction test application page includes a correction item selection box 11, a sample source selection box 12, a sample test selection box 13, a sample rack number input box 14, a sample number input box 15, a correction test plan input box 16, and a patient information input box 17. The correction item selected in the correction item selection box 11 is APTT. The source of the standard mixed blood sample selected in the sample source selection box 12 is "using the sample in the 1st position", that is, the user's self-made standard mixed blood sample is used for the correction test, and the user's self-made standard mixed blood sample is placed in the 1st position of the sample rack corresponding to the sample rack number "3434". It can be understood that the position of the sample tube containing the standard mixed blood sample on the sample rack may not be limited to the 1st position of the sample rack, but may also be any other position on the sample rack. The embodiments of the present invention do not make specific limitations on this.

[0040] The analysis strategy of the standard mixed blood sample selected in the sample test selection box 13 is "analyze each sample separately for NPP", that is, in the case where there are multiple blood samples to be tested that need to be corrected, it is necessary to analyze the standard mixed blood sample for each blood sample to be tested once, and each blood sample to be tested does not share the coagulation analysis results of the standard mixed blood sample. In addition, the analysis strategy of the standard mixed blood sample may also be "analyze all samples together for NPP". In the case where there are multiple blood samples to be tested that need to be corrected, only one coagulation analysis result of the standard mixed blood sample is required, and the correction tests of multiple blood samples to be tested share the coagulation analysis results of the standard mixed blood sample.

[0041] The sample tube rack number entered in the sample tube rack number input box 14 is "3434", which means that when conducting a correction test, the sample tube rack corresponding to the sample tube rack number "3434" is used. The sample numbers entered in the sample number input box 15 include the sample number "123456789" of the blood sample to be tested, and the blood sample to be tested that needs to be corrected is placed in the 2nd position of the sample tube rack corresponding to the sample tube rack number "3434". The mixing ratio entered in the correction test plan input box 16 is 1:1, and the user selects "point-of-care testing", indicating that a point-of-care correction test is to be performed on the blood sample to be tested. No patient information is entered in the patient information input box 17.

[0042] For another example, as Figure 3 shown, the source of the standard mixed blood sample selected in the sample source selection box 12 is "automatically prepared by the instrument", that is, the standard mixed blood sample prepared by the coagulation analyzer is used for the correction test. The sample numbers entered in the sample number input box 15 include the sample numbers of two blood samples to be tested, which are "12345678" and "123456789" respectively. The blood sample to be tested with the sample number "12345678" is placed in the 1st position of the sample tube rack corresponding to the sample tube rack number "3434", and the blood sample to be tested with the sample number "123456789" is placed in the 2nd position of the sample tube rack corresponding to the sample tube rack number "3434". The correction test plan for the blood sample to be tested with the sample number "12345678" includes a mixing ratio of 1:1, performing an immediate correction test and a delayed correction test, and an incubation time of 120 minutes. The correction test plan for the blood sample to be tested with the sample number "123456789" includes a mixing ratio of 1:1 and performing an immediate correction test.

[0043] It can be understood that after the user configures the correction test application information, if the user chooses to use the standard mixed blood sample prepared by himself / herself, the user needs to place the sample tube containing the standard mixed blood sample and the sample tube containing the blood sample to be tested on the sample tube rack, and then place the sample tube rack on the sample injection mechanism of the coagulation analyzer. In this way, the sample injection mechanism will push the sample tube rack into the coagulation analyzer, and the coagulation analyzer can aspirate the standard mixed blood sample in the sample tube for the correction test. If the user chooses the standard mixed blood sample prepared by the coagulation analyzer, the user needs to place the sample tube containing the blood sample to be tested on the sample tube rack, and there is no need for the user to place the sample tube containing the standard mixed blood sample on the sample tube rack. Then place the sample tube rack on the sample injection mechanism of the coagulation analyzer, and in this way, the sample injection mechanism will push the sample tube rack into the coagulation analyzer.

[0044] In one embodiment, in response to a user's trigger operation on the correction test start control button, a correction test start instruction is generated. Based on the correction test start instruction, the correction test application information configured by the user is obtained. Herein, the correction test start control button can be a physical button provided on the coagulation analyzer or a virtual button provided on the display interface, and the embodiments of the present invention do not make specific limitations thereto. After the user completes the configuration of the correction test application information and places the blood sample to be tested, the correction test of the blood sample to be tested can be started through the correction test start control button.

[0045] In one embodiment, during the daily detection work of the coagulation analyzer, the coagulation analyzer can prepare a standard mixed blood sample according to the sample preparation rule corresponding to the user's target coagulation index item. Specifically: after the coagulation analyzer performs coagulation analysis on the patient's blood sample each time, the coagulation analysis result of the patient's blood sample is obtained; according to the value of the target coagulation index item in the coagulation analysis result, it is determined whether the patient's blood sample is a normal blood sample; when the patient's blood sample is a normal blood sample, it is determined whether the standard mixed blood sample in the sample pool corresponding to the target coagulation index item is prepared; when the standard mixed blood sample in the sample pool is not prepared, the sample preparation rule is obtained, and the sample preparation rule includes a sample screening rule and a sample quantity; it is determined whether the patient's blood sample meets the sample screening rule; when the patient's blood sample meets the sample screening rule, the sampling mechanism is controlled to aspirate the patient's blood sample in the buffer cup into the sample pool corresponding to the target coagulation index item for mixing; when the first quantity of the normal blood sample added to the sample pool reaches the sample quantity in the sample preparation rule, it is determined that the standard mixed blood sample in the sample pool is prepared, and the preparation of the standard mixed blood sample is stopped.

[0046] In one embodiment, the daily detection work of the coagulation analyzer includes: obtaining the position information of the sample tube containing the patient's blood sample on the sample tube rack, and according to the position information, controlling the sampling mechanism to aspirate the patient's blood sample in the corresponding sample tube into the buffer cup according to a preset first sampling volume; controlling the sampling mechanism to aspirate the patient's blood sample in the buffer cup into the reaction cup in the coagulation analyzer according to a preset second sampling volume, and the first sampling volume is greater than the second sampling volume; performing coagulation analysis on the patient's blood sample in the reaction cup to obtain a coagulation analysis result.

[0047] Among them, the first sample aspiration volume and the second sample aspiration volume are the volumes of samples aspirated by the sample aspiration mechanism. The first sample aspiration volume and the second sample aspiration volume can be set by the user based on actual situations, and the embodiments of the present invention do not make specific limitations thereon. For example, the first sample aspiration volume is 250 microliters, and the second sample aspiration volume is 50 microliters. Exemplarily, the sample aspiration mechanism may include a first sample aspiration component and a second sample aspiration component. The first sample aspiration component aspirates the patient blood sample in the corresponding sample tube to the buffer cup according to the preset first sample aspiration volume, and the second sample aspiration component aspirates the patient blood sample in the buffer cup to the reaction cup according to the preset second sample aspiration volume. Of course, there may also be only one sample aspiration mechanism, which successively aspirates the patient blood sample in the corresponding sample tube to the buffer cup, and then aspirates the patient blood sample in the buffer cup to the reaction cup. By reserving the patient blood sample in the sample tube corresponding to the position of the first sample tube in the buffer cup, when preparing the standard mixed blood sample, the patient blood sample can be directly aspirated from the buffer cup, and there is no need to aspirate the patient blood sample from the sample tube, thereby improving the preparation efficiency of the standard mixed blood sample. It is worth noting that the buffer cup and the reaction cup can be of the same type of sample container or different types of sample containers, and no limitation is made here.

[0048] In one embodiment, when the patient blood sample meets the sample screening rule without using the buffer cup, the sampling mechanism can also be controlled to drive the sample tube to which the patient blood sample belongs to retreat to the sampling position, and the sampling mechanism is controlled to aspirate the patient blood sample in the sample tube located at the sampling position into the sample pool for mixing. Since the sample tube advances along the sampling path with the sampling mechanism, in order to ensure the detection efficiency of the coagulation analyzer, after the sampling mechanism aspirates the sample in the current sample tube at the sampling position to aspirate the current patient blood sample, the sampling mechanism drives the sample rack to continue to advance so that the sampling mechanism aspirates the next blood sample in the next sample tube at the sampling position, and then continuously performs coagulation detection and analysis. When the current sample to be tested meets the sample screening rule, the current sample tube has left the sampling position. Therefore, when the patient blood sample meets the sample screening rule, the sampling mechanism needs to retreat, driving the current sample tube to retreat, and the sampling mechanism aspirates the current patient blood sample in the current sample tube again and aspirates the current patient blood sample into the sample pool for mixing.

[0049] In one embodiment, after adding one patient blood sample to the sample pool corresponding to the target coagulation index item each time, the first quantity of the patient blood sample aspirated into the sample pool is incremented by 1. And after adding one patient blood sample to the sample pool corresponding to the target coagulation index item each time, it is determined whether the standard mixed blood sample in the sample pool is prepared based on the first quantity. When the first quantity of the patient blood sample aspirated into the sample pool reaches the sample quantity, it is determined that the standard mixed blood sample in the sample pool is prepared, and the preparation of the standard mixed blood sample is stopped. While when the first quantity of the patient blood sample aspirated into the sample pool is less than the sample quantity, patient blood samples that meet the sample screening rules are continuously screened from the subsequent patient blood sample detection process, and the patient blood samples that meet the sample screening rules are added to the sample pool.

[0050] In one embodiment, the sampling mechanism is controlled to aspirate a preset volume of patient blood sample from the buffer cup, and the sampling needle assembly is controlled to discharge the aspirated patient blood sample into the sample pool corresponding to the target coagulation index item; the sampling needle assembly is controlled to perform multiple sucking and discharging actions or stirring actions in the sample pool corresponding to the target coagulation index item to mix the patient blood samples in the sample pool. Among them, the preset volume can be set according to the actual situation, and the embodiments of the present invention do not make specific limitations on this.

[0051] In one embodiment, when the patient blood sample meets the sample screening rules, the second quantity of the first blood sample added to the sample pool is obtained, and the first blood sample is the patient blood sample that meets the sample screening rules; when the second quantity is less than the sample screening quantity, the sampling mechanism is controlled to aspirate the patient blood sample in the buffer cup into the sample pool for mixing.

[0052] For example, the sample preparation rules include sample screening rule A and sample screening rule B. The specified age range, specified gender, and sample screening quantity included in sample screening rule A are 15 to 65 years old, male, and 12 respectively. The specified age range, specified gender, and sample screening quantity included in sample screening rule B are 15 to 65 years old, female, and 8 respectively. When the patient blood sample C meets sample screening rule A, if the number of patient blood samples that meet sample screening rule A added to the sample pool is 8, it means that the number of patient blood samples that meet sample screening rule A added to the sample pool is insufficient, and then the patient blood sample C is added to the sample pool for mixing.

[0053] For another example, when the patient blood sample C meets the sample screening rule A, if the number of patient blood samples that meet the sample screening rule A added to the sample pool is 12, and the number of patient blood samples that meet the sample screening rule B added to the sample pool is 6, it means that the number of patient blood samples that meet the sample screening rule A added to the sample pool is sufficient, while the number of patient blood samples that meet the sample screening rule B added to the sample pool is insufficient. Then, the patient blood sample C is not added to the sample pool, and subsequently, the patient blood samples that meet the sample screening rule B are screened and added to the sample pool for mixing.

[0054] In one embodiment, when the second quantity is equal to the sample screening quantity, the transfer mechanism is controlled to discard the buffer cup containing the patient blood sample. For example, when the patient blood sample C meets the sample screening rule A, if the number of patient blood samples that meet the sample screening rule A added to the sample pool is 12, it means that the number of patient blood samples that meet the sample screening rule A added to the sample pool is sufficient. Therefore, the transfer mechanism is controlled to discard the buffer cup containing the patient blood sample C.

[0055] Exemplarily, the way to control the transfer mechanism to discard the buffer cup containing the patient blood sample can be: controlling the transfer mechanism to transfer the buffer cup containing the patient blood sample to the waste cup placement bin to discard the buffer cup containing the patient blood sample. Among them, the waste cup placement bin can be an internal component of the coagulation analyzer or an external component of the coagulation analyzer.

[0056] In one embodiment, when the patient blood sample does not meet the sample screening rule, the transfer mechanism is controlled to discard the buffer cup containing the patient blood sample. By discarding the buffer cup when the patient blood sample does not meet the sample screening rule, thereby disposing of the patient blood sample, the preparation accuracy of the standard mixed blood sample can be improved.

[0057] In one embodiment, after the standard mixed blood sample in the sample pool is prepared, the temperature of the sample pool is controlled within a preset temperature range. Exemplarily, after adding the second blood sample to the sample pool corresponding to the target coagulation index item, the temperature of the sample pool is controlled within a preset temperature range. The second blood sample is the first or the last normal blood sample added to the sample pool. Among them, the preset temperature range can be set based on the actual situation, and the embodiments of the present invention do not make specific limitations in this regard. For example, the preset temperature range is about 8 degrees Celsius. By controlling the temperature of the sample pool within the preset temperature range after adding the second blood sample to the sample pool corresponding to the target coagulation index item, the effective duration of the standard mixed blood sample in the sample pool can be improved.

[0058] In one embodiment, the sample preparation rule further includes the expiration period of the standard mixed blood sample. After the preparation of the standard mixed blood sample in the sample pool is completed, obtain the sampling time of the second blood sample, where the sampling time is the time when the second blood sample is collected from the patient; alternatively, obtain the sample delivery time of the second blood sample, where the sample delivery time is the time when the testing department receives the second blood sample; alternatively, obtain the time when the second blood sample is put into the pool, where the time when the second blood sample is put into the pool is the time when the second blood sample is added to the sample pool; alternatively, obtain the completion time of the preparation of the standard mixed blood sample, where the completion time of the preparation is the time when the preparation of the standard mixed blood sample in the sample pool is completed; set an expiration period for the sample pool, and set the sampling time, sample delivery time, time when the second blood sample is put into the pool, or completion time of the preparation as the starting time of the expiration period; where the second blood sample is the first or last normal blood sample added to the sample pool.

[0059] In one embodiment, the sample preparation rule further includes a rule for determining the starting time of the expiration period. When the rule for determining the starting time of the expiration period is the first determination rule, obtain the sampling time of the second blood sample, where the sampling time is the time when the second blood sample is collected from the patient; set the sampling time of the second blood sample as the starting time of the expiration period of the standard mixed blood sample in the sample pool. Where the first determination rule is a rule that uses the sampling time of the second blood sample as the starting time of the expiration period.

[0060] In one embodiment, when the rule for determining the starting time of the expiration period is the second determination rule, obtain the sample delivery time of the second blood sample, where the sample delivery time is the time when the testing department receives the second blood sample; set the sample delivery time of the second blood sample as the starting time of the expiration period of the standard mixed blood sample in the sample pool. The second determination rule is a rule that uses the sample delivery time of the second blood sample as the starting time of the expiration period.

[0061] In one embodiment, when the rule for determining the starting time of the expiration period is the third determination rule, obtain the time when the second blood sample is put into the pool, where the time when the second blood sample is put into the pool is the time when the second blood sample is added to the sample pool; set the time when the second blood sample is put into the pool as the starting time of the expiration period of the standard mixed blood sample in the sample pool. Where the third determination rule is a rule that uses the mixing time of the second blood sample as the starting time of the expiration period.

[0062] In one embodiment, when the rule for determining the starting time of the expiration period is the fourth determination rule, obtain the completion time of the preparation of the standard mixed blood sample, where the completion time of the preparation is the time when the preparation of the standard mixed blood sample in the sample pool is completed; set the completion time of the preparation as the starting time of the expiration period of the standard mixed blood sample in the sample pool. Where the fourth determination rule is a rule that uses the completion time of the preparation of the normal mixed blood as the starting time of the expiration period.

[0063] In one embodiment, according to the expiration date and start time, determine the valid time range of the standard mixed blood sample in the sample pool; when the current system time of the coagulation analyzer is not within the valid time range, determine that the standard mixed blood sample in the sample pool has expired, and control the sample pool to discharge the standard mixed blood sample; after the sample pool discharges the standard mixed blood sample, clean the sample pool. By controlling the sample pool to discharge the standard mixed blood sample and cleaning the sample pool after the standard mixed blood sample in the sample pool has expired, the sample pool can be reused, improving the utilization rate of the sample pool.

[0064] In one embodiment, according to the expiration date and start time, determine the valid time range of the standard mixed blood sample in the sample pool; when the current system time of the coagulation analyzer exceeds the valid time range, determine that the standard mixed blood sample in the sample pool has expired, and discharge the standard mixed blood sample in the sample pool; after the sample pool discharges the standard mixed blood sample, clean the sample pool or discard the sample pool. By discharging the standard mixed blood sample in the sample pool after the standard mixed blood sample in the sample pool has expired and cleaning the sample pool after the sample pool discharges the standard mixed blood sample, the sample pool can be reused, improving the utilization rate of the sample pool.

[0065] It can be understood that the coagulation analyzer can prepare multiple standard mixed blood samples. For example, the coagulation analyzer includes a first sample pool and a second sample pool. The first sample pool is used to prepare the standard mixed blood sample required for APTT, and the second sample pool is used to prepare the standard mixed blood sample required for PT. The user can set the first sample preparation rule for the first sample pool and the second sample preparation rule for the second sample pool. In this way, after the coagulation analyzer performs coagulation analysis on the patient's blood sample, if the patient's blood sample is a normal blood sample and the patient's blood sample meets the sample screening rule in the first sample preparation rule, then control the sampling mechanism to aspirate the patient's blood sample in the buffer cup into the first sample pool for mixing. And if the patient's blood sample is a normal blood sample and the patient's blood sample meets the sample screening rule in the second sample preparation rule, then control the sampling mechanism to aspirate the patient's blood sample in the buffer cup into the second sample pool for mixing. If the patient's blood sample is a normal blood sample, the patient's blood sample meets the sample screening rule in the first sample preparation rule, and the patient's blood sample meets the sample screening rule in the second sample preparation rule, control the sampling mechanism to aspirate the patient's blood sample in the buffer cup into the first sample pool for mixing, and control the sampling mechanism to aspirate the patient's blood sample in the buffer cup into the second sample pool for mixing.

[0066] Step S102: Control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the position of the first sample tube into the reaction cup, and according to the correction test plan, use the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup.

[0067] In the embodiment of the present invention, the coagulation analyzer includes a sampling mechanism, a placement mechanism, one or more sample pools, a sample injection mechanism, a transfer mechanism, and a detection mechanism. The sampling mechanism is used to aspirate blood samples, the placement mechanism is used to place reaction cups, the reaction cups are used to hold blood samples to be tested, the sample pools are used to prepare and hold standard mixed blood samples, the transfer mechanism is used to transfer the reaction cups to the detection position of the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood samples in the reaction cups located in the detection area.

[0068] In the embodiment of the present invention, the correction test plan includes a first correction test plan, a second correction test plan, or a third correction test plan. The first correction test plan includes a first correction test type and a mixing ratio. The first correction test type is used to describe that the correction test is an immediate correction test. The second correction test plan includes a second correction test type, a mixing ratio, a mixed sample type, and a sample incubation duration. The second correction test type is used to describe that the correction test is a delayed correction test. The mixed sample type includes a first sample type and / or a second sample type. The first sample type refers to the sample type in which the samples are mixed first and then incubated, and the second sample type refers to the sample type in which the samples are incubated first and then mixed. The third correction test plan includes a mixing ratio and a sample incubation duration. The third correction test plan is a correction test plan that requires both an immediate correction test and a delayed correction test.

[0069] It can be understood that when the correction test plan for the target coagulation index item is the first correction test plan, the coagulation analyzer performs an immediate correction test on the blood sample to be tested. When the correction test plan for the target coagulation index item is the second correction test plan, the coagulation analyzer performs a delayed correction test on the blood sample to be tested. When the correction test plan for the target coagulation index item is the third correction test plan, the coagulation analyzer performs both an immediate correction test and a delayed correction test on the blood sample to be tested.

[0070] In one embodiment, when the correction test protocol is the first correction test protocol, the sampling mechanism is controlled to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup on the placement mechanism; the sampling mechanism is controlled to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup on the placement mechanism; according to the mixing ratio, the sampling mechanism is controlled to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the placement mechanism and aspirate the standard mixed blood sample in the sample pool into the third reaction cup for mixing; the transfer mechanism is controlled to transfer the first reaction cup, the second reaction cup, and the third reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the first reaction cup, the standard mixed blood sample in the second reaction cup, and the mixed sample in the third reaction cup located in the detection area.

[0071] Exemplarily, the sampling mechanism may include a first sampling component and a second sampling component. The first sampling component aspirates the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup and the third reaction cup, and the second sampling component aspirates the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup. Exemplarily, the sampling mechanism may further include a plurality of sampling components, and the sampling operations respectively performed by the plurality of sampling components are not limited herein. For example, the first sampling component aspirates the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup, the second sampling component aspirates the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup, and the third sampling component aspirates the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup.

[0072] Exemplarily, according to the mixing ratio, the manner of controlling the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the placement mechanism and aspirate the standard mixed blood sample in the sample pool into the third reaction cup for mixing may be as follows: controlling the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup according to a preset sampling volume; determining a target sampling volume according to the mixing ratio and the preset sampling volume, and controlling the sampling mechanism to aspirate the standard mixed blood sample in the sample pool into the third reaction cup according to the target sampling volume; controlling the sampling mechanism to perform a preset number of suction and discharge actions or stirring actions in the third reaction cup to mix the blood sample to be tested and the standard mixed blood sample in the third reaction cup. Among them, the preset sampling volume and the preset number of times can be set based on the actual situation, and the embodiments of the present invention do not make specific limitations thereon. For example, the preset sampling volume is 50 microliters and the preset number of times is 5 times.

[0073] In one embodiment, the coagulation analyzer further includes a transfer mechanism and a detection mechanism. The placement mechanism includes a loading component and a heating component. The loading component is used to load reaction cups. When the correction test plan is the second correction test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the loading component; control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the loading component; when the mixed sample type is the first sample type, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the loading component and sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the sixth reaction cup for mixing; control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; when the incubation duration reaches the sample incubation duration, control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, and the sixth reaction cup to the corresponding detection area of the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup located in the detection area.

[0074] In one embodiment, when the correction test plan is the second correction test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the loading component; control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the loading component; when the mixed sample type is the second sample type, control the heating component to incubate the blood sample to be tested in the fourth reaction cup and the standard mixed blood sample in the fifth reaction cup; when the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the fourth reaction cup into the seventh reaction cup on the loading component and sample the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, and the seventh reaction cup to the corresponding detection area of the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the seventh reaction cup located in the detection area.

[0075] In one embodiment, when the correction test protocol is the second correction test protocol, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the carrier assembly; control the sampling mechanism to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the carrier assembly; when the mixed sample type includes the first sample type and the second sample type, according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the carrier assembly and aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the sixth reaction cup for mixing; control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; when the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the fourth reaction cup into the seventh reaction cup on the carrier assembly and aspirate the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, the sixth reaction cup, and the seventh reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, the mixed sample in the sixth reaction cup, and the mixed sample in the seventh reaction cup located in the detection area.

[0076] In one embodiment, when the correction test scheme is the third correction test scheme, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup on the carrying component; control the sampling mechanism to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup on the carrying component; according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the carrying component and aspirate the standard mixed blood sample in the sample pool into the third reaction cup for mixing; control the transfer mechanism to transfer the first reaction cup, the second reaction cup and the third reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the first reaction cup located in the detection area, the standard mixed blood sample in the second reaction cup and the mixed sample in the third reaction cup; control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the carrying component; control the sampling mechanism to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the carrying component; according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the carrying component and aspirate the standard mixed blood sample in the sample pool into the sixth reaction cup for mixing; control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup and the mixed sample in the sixth reaction cup; when the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the fourth reaction cup into the seventh reaction cup and aspirate the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, the sixth reaction cup and the seventh reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup located in the detection area, the standard mixed blood sample in the fifth reaction cup, the mixed sample in the sixth reaction cup and the mixed sample in the seventh reaction cup.

[0077] In one embodiment, the correction test application information further includes multiple first sample tube positions, and the coagulation analyzer uses the same standard mixed blood sample to perform correction tests on the blood samples to be tested in the sample tubes corresponding to each first sample tube position respectively. Among them, the correction test application information including multiple first sample tube positions indicates that there are multiple blood samples to be tested in the sample tubes placed on the sample tube rack that need to be corrected, and the coagulation analyzer uses the same standard mixed blood sample to perform correction tests on the blood samples to be tested in the sample tubes corresponding to each first sample tube position respectively, which can improve the utilization rate of the standard mixed blood sample.

[0078] For example, a sample tube containing the first blood sample to be tested is placed at the 1st position of the sample tube rack, a sample tube containing the second blood sample to be tested is placed at the 2nd position, and a sample tube containing the third blood sample to be tested is placed at the 3rd position. When performing a correction test on the first, second, and third blood samples to be tested, the same standard mixed blood sample can be used for the correction test.

[0079] In one embodiment, during the process of performing a correction test on the blood samples to be tested in the sample tubes corresponding to each first sample tube position, the coagulation analyzer performs a single coagulation analysis on the standard mixed blood sample, and the blood samples to be tested in the sample tubes corresponding to each first sample tube position share the coagulation analysis result of the standard mixed blood sample. For example, a sample tube containing the first blood sample to be tested is placed at the 1st position of the sample tube rack, a sample tube containing the second blood sample to be tested is placed at the 2nd position, and a sample tube containing the third blood sample to be tested is placed at the 3rd position. When performing a correction test on the first, second, and third blood samples to be tested, the coagulation analyzer performs a single coagulation analysis on the standard mixed blood sample A to obtain a coagulation analysis result, and the first, second, and third blood samples to be tested share the coagulation analysis result of the standard mixed blood sample A.

[0080] In one embodiment, during the process of performing a correction test on the blood samples to be tested in the sample tubes corresponding to each first sample tube position, the coagulation analyzer performs a single coagulation analysis on the standard mixed blood sample for each blood sample to be tested in the sample tubes corresponding to each first sample tube position. For example, a sample tube containing the first blood sample to be tested is placed at the 1st position of the sample tube rack, a sample tube containing the second blood sample to be tested is placed at the 2nd position, and a sample tube containing the third blood sample to be tested is placed at the 3rd position. When performing a correction test on the first blood sample to be tested, the coagulation analyzer performs a coagulation analysis on the standard mixed blood sample A. When performing a correction test on the second blood sample to be tested, the coagulation analyzer also performs a coagulation analysis on the standard mixed blood sample A. When performing a correction test on the third blood sample to be tested, the coagulation analyzer also performs a coagulation analysis on the standard mixed blood sample A.

[0081] In one embodiment, after performing step S102, the coagulation analysis results of the blood samples participating in the correction test are obtained and the coagulation analysis results of the blood samples are output; according to the coagulation analysis results of the blood samples, a correction test comparison chart is generated and output, and the correction test comparison chart includes the coagulation analysis results of the blood samples. Among them, the coagulation analysis results of the blood samples include the measured values of the target coagulation index items of the blood samples. By generating and outputting the correction test comparison chart, the inspection personnel can know the coagulation analysis results of the blood samples.

[0082] For example, when the correction test protocol is the first correction test protocol, the coagulation analysis results of the blood sample to be tested in the first reaction cup, the standard mixed blood sample in the second reaction cup, and the mixed sample in the third reaction cup can be obtained. When the correction test protocol is the second correction test protocol and the mixed sample types include the first mixed sample type and the second mixed sample type, the coagulation analysis results of the incubated blood sample to be tested in the first reaction cup, the incubated standard mixed blood sample in the second reaction cup, the incubated mixed sample in the third reaction cup, and the mixed sample (mixed after incubation) in the fourth reaction cup can be obtained.

[0083] For example, as Figure 4 shown, the correction test comparison chart 21 and the coagulation analysis result table 22 include the measured values of APTT1, APTT2, APTT3, APTT4, APTT5, APTT6, and APTT7. APTT1 is the APTT of the blood sample to be tested, APTT2 is the APTT of the standard mixed blood sample, APTT3 is the APTT of the first mixed sample, the first mixed sample is obtained by mixing the blood sample to be tested and the standard mixed blood sample in a mixing ratio of 1:1, APTT4 is the APTT of the blood sample to be tested incubated for 2 hours, APTT5 is the APTT of the standard mixed blood sample incubated for 2 hours, APTT6 is the APTT of the second mixed sample, the second mixed sample is obtained by mixing the blood sample to be tested and the standard mixed blood sample in a mixing ratio of 1:1 and incubating for 2 hours, and APTT7 is the APTT of the third mixed sample, the third mixed sample is obtained by mixing the blood sample to be tested incubated for 2 hours and the standard mixed blood sample incubated for 2 hours in a mixing ratio of 1:1.

[0084] In one embodiment, obtain the correction test determination rule corresponding to the target coagulation index item; according to the correction test determination rule and the coagulation analysis results of each blood sample, determine the correction test results of each mixed sample participating in the correction test; according to the correction test results of each mixed sample participating in the correction test and the coagulation analysis results of each blood sample, generate and output a correction test inspection report. By generating and outputting a correction test inspection report, the user can know the correction test inspection results.

[0085] Among them, the determination rules for the correction test may include the normal reference range interval of the target coagulation index item, or include the correction interval, non-correction interval of the Rosner index, and the upper threshold and / or lower threshold of the gray zone, or include the correction interval, non-correction interval of the correction percentage, and the upper threshold and / or lower threshold of the gray zone, or include the absolute value threshold or the relative deviation percentage threshold. The gray zone refers to the Rosner index interval or the correction percentage interval in which the target coagulation index item of the mixed sample cannot be determined.

[0086] Exemplarily, when the determination rule for the correction test includes the normal reference range interval of the target coagulation index item, if the measured value of the target coagulation index item of the mixed sample is within the normal reference interval, it is determined that the correction result of the mixed sample is "corrected"; if the measured result of the target coagulation index item of the mixed sample is not within the normal reference interval, it is determined that the correction result of the mixed sample is "not corrected". For example, as Figure 4 shown, APTT3 is the measured value of the first mixed sample. If APTT3 is within the normal reference interval, the correction result of APTT3 is "corrected"; if APTT3 is not within the normal reference interval, the correction result of APTT3 is "not corrected".

[0087] Exemplarily, when the determination rule for the correction test includes the correction interval, non-correction interval of the Rosner index, and the gray zone, calculate the Rosner index of each mixed sample according to the RI index calculation formula. If the Rosner index of the mixed sample is within the correction interval, it is determined that the correction result of the mixed sample is "corrected"; if the Rosner index of the mixed sample is within the non-correction interval, it is determined that the correction result of the mixed sample is "not corrected"; if the Rosner index is within the gray zone, it is determined that the correction result of the mixed sample is "unable to correct".

[0088] Exemplarily, when the determination rule for the correction test includes the correction interval, non-correction interval of the correction percentage, and the gray zone, calculate the correction percentage of each mixed sample according to the correction percentage calculation formula. If the correction percentage of the mixed sample is within the correction interval, it is determined that the correction result of the mixed sample is "corrected"; if the correction percentage of the mixed sample is within the non-correction interval, it is determined that the correction result of the mixed sample is "not corrected"; if the correction percentage is within the gray zone, it is determined that the correction result of the mixed sample is "unable to correct".

[0089] Exemplarily, when the correction test determination rule includes the absolute value threshold of the target coagulation index item, calculate the absolute value of the difference between the measured value of the target coagulation index item of the mixed sample and the measured value of the target coagulation index item of the standard mixed blood sample. When the absolute value of the difference is less than or equal to the absolute value threshold, determine that the correction result of the mixed sample is "corrected"; otherwise, determine that the correction result of the mixed sample is "not corrected".

[0090] Exemplarily, when the correction test determination rule includes the relative deviation percentage threshold, calculate the deviation value between the measured value of the target coagulation index item of the mixed sample and the measured value of the target coagulation index item of the standard mixed blood sample, and divide the deviation value by the measured value of the target coagulation index item of the standard mixed blood sample to obtain the relative deviation percentage. When the relative deviation percentage is less than or equal to the relative deviation percentage threshold, it can be determined that the correction result of the mixed sample is "corrected"; otherwise, determine that the correction result of the mixed sample is "not corrected".

[0091] For the correction test initiation method provided in the above embodiments, in the case where a correction test is required, the user can configure the correction test application information. In this way, the coagulation analyzer can perform the correction test according to the correction test application information, and the coagulation analyzer uses the standard mixed blood sample in the sample pool according to the correction test plan in the correction test application information to perform the correction test on the blood sample to be tested. There is no need for the user to manually prepare the standard mixed blood sample, and the entire process of the correction test does not require manual participation and is automatically completed by the coagulation analyzer, which greatly improves the execution efficiency and accuracy of the correction test.

[0092] Please refer to Figure 5 , Figure 5 which is a schematic flowchart of another correction test initiation method provided by an embodiment of the present invention.

[0093] As Figure 5 shown, this correction test initiation method includes steps S201 to S204.

[0094] Step S201: Obtain the correction test application information configured by the user;

[0095] Step S202: Control the coagulation analyzer to be in the first correction test mode or the second correction test mode according to the sample source identifier;

[0096] Step S203: In the first correction test mode, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and use the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform the correction test on the blood sample to be tested in the reaction cup according to the correction test plan;

[0097] Step S204: In the second correction test mode, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and according to the correction test plan, use the standard mixed blood sample in the sample tube corresponding to the second sample tube position in the correction test application information to perform a correction test on the blood sample to be tested in the reaction cup.

[0098] In an embodiment of the present invention, the coagulation analyzer includes a first correction test mode and a second correction test mode. In the first correction test mode, the coagulation analyzer uses the standard mixed blood sample in the sample pool to perform a correction test. In the second correction test mode, the coagulation analyzer uses the standard mixed blood sample manually prepared by the user to perform a correction test. The correction test application information may include the target coagulation index item, the correction test plan, the first sample tube position, and the sample source identifier, or the correction test application information may include the target coagulation index item, the correction test plan, the first sample tube position, the second sample tube position, and the sample source identifier. The sample source identifier is used to indicate the source of the standard mixed blood sample used for the correction test. The sample source identifier may include a first sample source identifier or a second sample source identifier. The first sample source identifier is used to indicate that the standard mixed blood sample used for the correction test is the standard mixed blood sample automatically prepared by the coagulation analyzer, and the second sample source identifier is used to indicate that the standard mixed blood sample used for the correction test is the standard mixed blood sample manually prepared by the user.

[0099] In one embodiment, when the sample source identifier is the first sample source identifier, control the coagulation analyzer to be in the first correction test mode; when the sample source identifier is the second sample source identifier, control the coagulation analyzer to be in the second correction test mode.

[0100] In one embodiment, when the correction test plan is the first correction test plan and the coagulation analyzer is in the second correction test mode, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup on the placement mechanism; control the sampling mechanism to aspirate the standard mixed blood sample in the sample tube corresponding to the second sample tube position into the second reaction cup on the placement mechanism; according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the placement mechanism and aspirate the standard mixed blood sample in the sample tube corresponding to the second sample tube position into the third reaction cup for mixing; control the transfer mechanism to transfer the first reaction cup, the second reaction cup, and the third reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the first reaction cup, the standard mixed blood sample in the second reaction cup, and the mixed sample in the third reaction cup located in the detection area.

[0101] In one embodiment, when the correction test protocol is the second correction test protocol and the coagulation analyzer is in the second correction test mode, the sampling mechanism is controlled to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the carrier assembly; the sampling mechanism is controlled to aspirate the standard mixed blood sample in the sample tube corresponding to the second sample tube position into the fifth reaction cup on the carrier assembly; when the mixed sample type is the first sample type, according to the mixing ratio, the sampling mechanism is controlled to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the carrier assembly and aspirate the standard mixed blood sample in the sample tube corresponding to the second sample tube position into the sixth reaction cup for mixing; the heating assembly is controlled to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; when the incubation duration reaches the sample incubation duration, the transfer mechanism is controlled to transfer the fourth reaction cup, the fifth reaction cup, and the sixth reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup located in the detection area.

[0102] It should be noted that those skilled in the art can clearly understand that for the convenience and conciseness of description, the specific working process of the correction test start method described above can refer to the corresponding process in the foregoing embodiments, and will not be repeated here.

[0103] In the embodiment of the present invention, since the coagulation analyzer includes a first correction test mode and a second correction test mode, the user can select to use the first correction test mode or the second correction test mode as needed. In the case of selecting to use the first correction test mode, the coagulation analyzer uses the standard mixed blood sample in the sample pool to perform the correction test, and the user does not need to manually prepare the standard mixed blood sample, and the entire process of the correction test does not require manual participation and is automatically completed by the coagulation analyzer. In the case of selecting to use the second correction test mode, the coagulation analyzer uses the standard mixed blood sample manually prepared by the user to perform the correction test. In this way, except that the preparation of the standard mixed blood sample needs to be manually completed by the user, the rest of the process of the correction test does not require manual participation by the user, greatly improving the execution efficiency and accuracy of the correction test.

[0104] Please refer to Figure 6 , Figure 6 which is a schematic block diagram of the structure of a control device provided by an embodiment of the present invention.

[0105] As shown in Figure 6As shown, the control device 300 includes a processor 301 and a memory 302. The processor 301 and the memory 302 are connected through a bus 303, which is, for example, an I2C (Inter-integrated Circuit) bus.

[0106] Specifically, the processor 301 is used to provide computing and control capabilities to support the operation of the entire control device. The processor 301 can be a central processing unit (CPU), and the processor 301 can also be other general-purpose processors, digital signal processors (DSPs), application specific integrated circuits (ASICs), field-programmable gate arrays (FPGAs), or other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. Among them, the general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc.

[0107] Specifically, the memory 302 can be a Flash chip, a read-only memory (ROM), a magnetic disk, an optical disc, a USB flash drive, a mobile hard disk, etc.

[0108] Those skilled in the art can understand that Figure 6 the structure shown in is only a block diagram of some structures related to the solution of the embodiment of the present invention, and does not constitute a limitation on the control device to which the solution of the embodiment of the present invention is applied. The specific control device may include more or fewer components than those shown in the figure, or combine some components, or have different component arrangements.

[0109] Among them, the processor 301 is used to run the computer program stored in the memory 302 and implement any one of the standard mixed blood sample preparation methods provided by the embodiments of the present invention when executing the computer program.

[0110] It should be noted that those skilled in the art can clearly understand that for the convenience and brevity of description, the specific working process of the above-described control device can refer to the corresponding process in the foregoing embodiment of the correction test start method, and will not be repeated here.

[0111] An embodiment of the present invention further provides a coagulation analyzer, which includes one or more sample pools, a sampling mechanism, a placement mechanism, and a control device. The one or more sample pools are used to prepare a standard mixed blood sample. The sampling mechanism is used to aspirate a blood sample to be tested or a standard mixed blood sample. The placement mechanism is used to place a plurality of reaction cups, and the reaction cups are used to place the blood sample to be tested aspirated by the sampling mechanism. The control device is used to implement any standard mixed blood sample preparation method provided in the specification of the embodiment of the present invention. Among them, the control device can be Figure 6 the control device shown in

[0112] It should be noted that those skilled in the art can clearly understand that for the convenience and simplicity of description, the specific working process of the coagulation analyzer described above can refer to the corresponding process in the embodiment of the foregoing standard mixed blood sample preparation method, and will not be elaborated herein.

[0113] An embodiment of the present invention further provides a storage medium for computer-readable storage. The storage medium stores one or more programs, and the one or more programs can be executed by one or more processors to implement any correction test start method provided in the specification of the embodiment of the present invention.

[0114] Among them, the storage medium can be the internal storage unit of the coagulation analyzer described in the foregoing embodiment, such as the hard disk or memory of the coagulation analyzer. The storage medium can also be an external storage device of the coagulation analyzer, such as a plug-in hard disk equipped on the coagulation analyzer, a Smart Media Card (SMC), a Secure Digital (SD) card, a Flash Card, etc.

[0115] Those of ordinary skill in the art will understand that all or some of the steps in the methods disclosed above, and the functional modules / units in systems and devices, can be implemented as software, firmware, hardware, and their appropriate combinations. In the hardware embodiments, the division between the functional modules / units mentioned above does not necessarily correspond to the division of physical components; for example, one physical component can have multiple functions, or one function or step can be executed by several physical components in cooperation. Some or all physical components can be implemented as software executed by a processor, such as a central processing unit, a digital signal processor, or a microprocessor, or can be implemented as hardware, or can be implemented as an integrated circuit, such as an application-specific integrated circuit. Such software can be distributed on a computer-readable medium, which can include a computer storage medium (or non-transitory medium) and a communication medium (or transitory medium). As is well known to those of ordinary skill in the art, the term computer storage medium includes volatile and non-volatile, removable and non-removable media implemented in any method or technology for storing information, such as computer-readable instructions, data structures, program modules, or other data. Computer storage media include, but are not limited to, RAM, ROM, EEPROM, flash memory, or other memory technologies, CD-ROM, digital versatile disk (DVD), or other optical disk storage, magnetic cassettes, tapes, magnetic disk storage, or other magnetic storage devices, or any other medium that can be used to store the desired information and can be accessed by a computer. In addition, as is well known to those of ordinary skill in the art, a communication medium typically contains computer-readable instructions, data structures, program modules, or other data in a modulated data signal such as a carrier wave or other transmission mechanism, and can include any information delivery medium.

[0116] It should be understood that the term "and / or" used in the specification and appended claims of the present invention refers to any combination and all possible combinations of one or more of the associated listed items, and includes these combinations. It should be noted that in this article, the term "comprising", "including", or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article, or system including a series of elements not only includes those elements, but also includes other elements not expressly listed, or also includes elements inherent to such process, method, article, or system. Without further limitation, an element defined by the statement "including one..." does not exclude the existence of additional identical elements in the process, method, article, or system including that element.

[0117] The serial numbers of the embodiments of the present invention above are only for description and do not represent the superiority or inferiority of the embodiments. As mentioned above, the above are only specific embodiments of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present invention can easily think of various equivalent modifications or substitutions, and these modifications or substitutions should all be covered within the protection scope of the present invention. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.

Claims

1. A coagulation analyzer, characterized in that, Comprising: One or more sample pools for preparing and holding standard mixed blood samples; A sampling mechanism for aspirating a blood sample to be tested or a standard mixed blood sample; A placement mechanism for placing one or more reaction cups for holding the blood sample to be tested aspirated by the sampling mechanism; A control device for implementing the following steps: After each coagulation analysis of a patient's blood sample by the coagulation analyzer, obtaining the coagulation analysis result of the patient's blood sample; Determining whether the patient's blood sample is a normal blood sample according to the value of the target coagulation index item in the coagulation analysis result; When the patient's blood sample is a normal blood sample, determining whether the standard mixed blood sample in the sample pool corresponding to the target coagulation index item is prepared; When the standard mixed blood sample in the sample pool corresponding to the target coagulation index item is not prepared, obtaining a sample preparation rule, which includes a sample screening rule and a sample quantity; Determining whether the patient's blood sample meets the sample screening rule; When the patient's blood sample meets the sample screening rule, controlling the sampling mechanism to aspirate the patient's blood sample into the sample pool corresponding to the target coagulation index item for mixing; When the first quantity of normal blood samples added to the sample pool corresponding to the target coagulation index item reaches the sample quantity, determining that the standard mixed blood sample in the sample pool corresponding to the target coagulation index item is prepared; Obtaining correction test application information configured by the user, where the correction test application information includes a target coagulation index item, a correction test plan, and a first sample tube position; Controlling the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and using the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup according to the correction test plan; 2. The coagulation analyzer according to claim 1, wherein, The correction test application information further includes a sample source identifier for indicating the source of the standard mixed blood sample used for the correction test. The control device is further used to implement the following steps: Controlling the coagulation analyzer to be in a first correction test mode or a second correction test mode according to the sample source identifier; In the first correction test mode, controlling the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and using the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup according to the correction test plan; In the second correction test mode, controlling the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and using the standard mixed blood sample in the sample tube corresponding to the second sample tube position in the correction test application information to perform a correction test on the blood sample to be tested in the reaction cup according to the correction test plan.

3. The coagulation analyzer according to claim 1 or 2, characterized in that, The correction test plan includes a first correction test plan, and the first correction test plan includes a first correction test type and a mixing ratio. The first correction test type is used to describe that the correction test is an immediate correction test. The coagulation analyzer further includes a transfer mechanism and a detection mechanism. When the control device controls the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and according to the correction test plan, uses the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup, it is used to implement: When the correction test plan is the first correction test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup on the placement mechanism; Control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup on the placement mechanism; According to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the placement mechanism and sample the standard mixed blood sample in the sample pool into the third reaction cup for mixing; Control the transfer mechanism to transfer the first reaction cup, the second reaction cup and the third reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the first reaction cup, the standard mixed blood sample in the second reaction cup and the mixed sample in the third reaction cup located in the detection area.

4. The coagulation analyzer according to claim 1 or 2, characterized in that, The coagulation analyzer further includes a transfer mechanism and a detection mechanism. The placement mechanism includes a bearing component and a heating component. The bearing component is used to bear the reaction cup. The correction test plan includes a second correction test plan, and the second correction test plan includes a second correction test type, a mixing ratio, a mixed sample type and a sample incubation duration. The second correction test type is used to describe that the correction test is a delayed correction test. When the control device controls the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup, and according to the correction test plan, uses the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a correction test on the blood sample to be tested in the reaction cup, it is used to implement: When the correction test plan is the second correction test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the bearing component; Control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the bearing component; When the mixed sample type is the first sample type, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the position of the first sample tube into the sixth reaction cup on the carrying component and sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the sixth reaction cup for mixing; Control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; When the incubation duration reaches the sample incubation duration, control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, and the sixth reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup located in the detection area.

5. The coagulation analyzer according to claim 1 or 2, characterized in that, The coagulation analyzer further includes a transfer mechanism and a detection mechanism, the placement mechanism includes a carrying component and a heating component, the carrying component is used to carry reaction cups, the corrective test plan includes a second corrective test plan, the second corrective test plan includes a second corrective test type, a mixing ratio, a mixed sample type, and a sample incubation duration, the second corrective test type is used to describe that the corrective test is a delay corrective test, and when the control device realizes controlling the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the position of the first sample tube into the reaction cup and use the standard mixed blood sample in the sample pool corresponding to the target coagulation index item to perform a corrective test on the blood sample to be tested in the reaction cup according to the corrective test plan, it is used to realize: When the corrective test plan is the second corrective test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the position of the first sample tube into the fourth reaction cup on the carrying component; Control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the carrying component; When the mixed sample type is the second sample type, control the heating component to incubate the blood sample to be tested in the fourth reaction cup and the standard mixed blood sample in the fifth reaction cup; When the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the fourth reaction cup into the seventh reaction cup on the carrying component and sample the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; Control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, and the seventh reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the seventh reaction cup located in the detection area.

6. The coagulation analyzer according to claim 1 or 2, characterized in that, The coagulation analyzer further includes a transfer mechanism and a detection mechanism. The placement mechanism includes a carrying component and a heating component. The carrying component is used to carry reaction cups. The correction test plan includes a second correction test plan. The second correction test plan includes a second correction test type, a mixing ratio, a mixed sample type, and a sample incubation duration. The second correction test type is used to describe that the correction test is a delayed correction test. When the control device realizes controlling the detection mechanism to perform a correction test on the blood sample to be tested according to the correction test plan, using the standard mixed blood sample in the sample pool corresponding to the target coagulation index item, it is used to realize: When the correction test plan is the second correction test plan, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the carrying component; Control the sampling mechanism to sample the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the carrying component; When the mixed sample type includes a first sample type and a second sample type, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the reaction cup carrying component and sample the standard mixed blood sample in the sample pool into the sixth reaction cup for mixing; Control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; When the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to sample the blood sample to be tested in the fourth reaction cup into the seventh reaction cup on the carrying component and sample the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; Control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, the sixth reaction cup, and the seventh reaction cup to the detection area corresponding to the detection mechanism. The detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, the mixed sample in the sixth reaction cup, and the mixed sample in the seventh reaction cup located in the detection area.

7. The coagulation analyzer according to claim 1 or 2, characterized in that, The coagulation analyzer further includes a transfer mechanism and a detection mechanism. The placement mechanism includes a carrying component and a heating component. The carrying component is used to carry reaction cups. The correction test plan includes a third correction plan. The third correction test plan includes a mixing ratio and a sample incubation duration. When the control device realizes controlling the sampling mechanism to sample the blood sample to be tested in the sample tube corresponding to the first sample tube position into the reaction cup and perform a correction test on the blood sample to be tested in the reaction cup according to the correction test plan, using the standard mixed blood sample in the sample pool corresponding to the target coagulation index item, it is used to realize: Control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the first reaction cup on the carrier assembly; Control the sampling mechanism to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the second reaction cup on the carrier assembly; According to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the third reaction cup on the carrier assembly and aspirate the standard mixed blood sample in the sample pool into the third reaction cup for mixing; Control the transfer mechanism to transfer the first reaction cup, the second reaction cup, and the third reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the first reaction cup, the standard mixed blood sample in the second reaction cup, and the mixed sample in the third reaction cup located in the detection area; Control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the fourth reaction cup on the carrier assembly; Control the sampling mechanism to aspirate the standard mixed blood sample in the sample pool corresponding to the target coagulation index item into the fifth reaction cup on the carrier assembly; According to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the sample tube corresponding to the first sample tube position into the sixth reaction cup on the carrier assembly and aspirate the standard mixed blood sample in the sample pool into the sixth reaction cup for mixing; Control the heating component to incubate the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, and the mixed sample in the sixth reaction cup; When the incubation duration reaches the sample incubation duration, according to the mixing ratio, control the sampling mechanism to aspirate the blood sample to be tested in the fourth reaction cup into the seventh reaction cup and aspirate the standard mixed blood sample in the fifth reaction cup into the seventh reaction cup for mixing; Control the transfer mechanism to transfer the fourth reaction cup, the fifth reaction cup, the sixth reaction cup, and the seventh reaction cup to the detection area corresponding to the detection mechanism, and the detection mechanism is used to perform coagulation analysis on the blood sample to be tested in the fourth reaction cup, the standard mixed blood sample in the fifth reaction cup, the mixed sample in the sixth reaction cup, and the mixed sample in the seventh reaction cup located in the detection area.

8. The coagulation analyzer according to claim 1 or 2, characterized in that, The corrective test application information further includes multiple first sample tube positions, and the coagulation analyzer uses the same standard mixed blood sample to perform corrective tests on the blood samples to be tested in the sample tubes corresponding to each of the first sample tube positions.

9. The coagulation analyzer according to claim 8, characterized in that, During the process of performing a correction test on the blood sample to be tested in each sample tube corresponding to each of the first sample tube positions, the coagulation analyzer performs a coagulation analysis on the standard mixed blood sample, and the blood samples to be tested in the sample tubes corresponding to each of the first sample tube positions share the coagulation analysis results of the standard mixed blood sample; Alternatively, the coagulation analyzer performs a coagulation analysis on the standard mixed blood sample for each blood sample to be tested in the sample tubes corresponding to each of the first sample tube positions respectively.

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