Stem cell storage device

Abstract

The present application discloses a stem cell storage device, comprising a support frame, a storage mechanism, a sealing cover, a driving mechanism, and a freezing mechanism, wherein the support frame is vertically arranged relative to the ground; the storage mechanism is arranged on the support frame, and the storage mechanism includes a supporting cylinder and a plurality of test tube dragging and dropping components, wherein the supporting cylinder is detachably arranged on the support frame, and the supporting cylinder is provided with a plurality of through slots; the plurality of test tube dragging and dropping components are respectively pivotally arranged in the through slots; the sealing cover is detachably arranged on the supporting cylinder; one end of the driving mechanism is connected to the sealing cover, and the other end of the driving mechanism is respectively pivotally connected to the corresponding test tube dragging and dropping components via a plurality of groups of first connecting rods; the freezing mechanism is slidably arranged on the supporting cylinder, one end of the freezing mechanism is sealedly connected to the supporting cylinder, and the other end of the freezing mechanism is clamped to the sealing cover. Thus, the device has the advantage of conveniently taking and placing test tubes, which can effectively improve the work efficiency of the staff.

Description

Technical Field

[0001] The present application relates to the technical field of stem cell storage, and in particular to a stem cell storage device. Background Art

[0002] Stem cells are a type of multipotent cell with the ability to self-replicate. Under certain conditions, they can differentiate into a variety of functional cells. Based on their developmental stage, stem cells are categorized as embryonic stem cells and adult stem cells. Based on their developmental potential, they are divided into three types: totipotent stem cells, pluripotent stem cells, and unipotent stem cells. Stem cells are immature, underdifferentiated cells with the potential to regenerate various tissues, organs, and the human body. They are known in the medical community as "universal cells." Stem cell storage tanks are commonly used in stem cell storage.

[0003] The relevant stem cell storage tank consists of a tank body and a sealing cover. When storing test tubes containing stem cells, the staff needs to open the sealing cover first, and then manually take out the test tube rack containing the test tubes from the tank body, and finally take the required test tubes from the test tube rack. This makes the steps of taking and placing the test tubes more cumbersome and inconvenient, affecting the work efficiency of the staff. Summary of the Invention

[0004] The present application aims to solve one of the technical problems in the related art at least to a certain extent.

[0005] To this end, one purpose of the present application is to provide a stem cell storage device that has the advantage of convenient access to test tubes and can effectively improve the work efficiency of staff.

[0006] To achieve the above-mentioned purpose, the first embodiment of the present application proposes a stem cell storage device, comprising a support frame, a storage mechanism, a sealing cover, a driving mechanism and a freezing mechanism, wherein the support frame is vertically arranged relative to the ground; the storage mechanism is arranged on the support frame, and the storage mechanism includes a support cylinder and a plurality of test tube dragging and dropping components, wherein the support cylinder is detachably arranged on the support frame, and the support cylinder is provided with a plurality of through slots; a plurality of the test tube dragging and dropping components are respectively pivotally arranged in the through slots, wherein the test tube dragging and dropping components are used to drag and drop test tubes containing stem cells; the sealing cover is detachably arranged on the support frame. On the supporting cylinder; one end of the driving mechanism is connected to the sealing cover, and the other end of the driving mechanism is pivotally connected to the corresponding test tube drag and drop components through multiple groups of first connecting rods, wherein the driving mechanism is used to drive the test tube drag and drop components to flip; the freezing mechanism is slidably arranged on the supporting cylinder, one end of the freezing mechanism is sealed with the supporting cylinder, and the other end of the freezing mechanism is clamped with the sealing cover, and the freezing mechanism is pivotally connected to the corresponding test tube drag and drop components through multiple groups of second connecting rods, wherein the test tube drag and drop components are used to drive the freezing mechanism to slide.

[0007] The stem cell storage device of the embodiment of the present application has the advantage of convenient placement and removal of test tubes, and can effectively improve the work efficiency of staff.

[0008] In addition, the stem cell storage device proposed in the present application may also have the following additional technical features:

[0009] In one embodiment of the present application, the test tube dragging and dropping component includes a test tube rack and two support shafts, wherein the test tube rack is suspended in the through slot, the top of the test tube rack is provided with a dropping hole, the bottom of the test tube rack is provided with a fixing hole, and the two sides of the top of the test tube rack are respectively pivotally connected to the other end of the driving mechanism through a first connecting rod; one end of the two support shafts is respectively fixedly connected to the two sides of the bottom end of the test tube rack, and the other ends of the two support shafts are respectively pivotally connected to the inner wall of the through slot.

[0010] In one embodiment of the present application, protective washers are respectively provided in the delivery hole and the fixing hole.

[0011] In one embodiment of the present application, the freezing mechanism includes an insulation cylinder, a refrigeration pipe and two sealing plugs, wherein the top end of the insulation cylinder is clamped with the sealing cover, the bottom end of the insulation cylinder is slidably connected to the support cylinder, and an annular groove is provided in the cylinder wall of the insulation cylinder, and a plurality of through holes connected to the annular groove are provided on the inner wall of the insulation cylinder, and the insulation cylinder is pivotally connected to the two sides of the bottom end of the test tube rack through a second connecting rod; the refrigeration pipe is spirally wrapped in the annular groove, and the inlet and outlet ends of the refrigeration pipe respectively pass through the cylinder wall of the insulation cylinder and are connected to the outside world, wherein the refrigeration pipe is used to hold frozen liquid; the two sealing plugs are respectively sealed and arranged at the inlet and outlet ends of the refrigeration pipe.

[0012] In one embodiment of the present application, an annular groove is provided on the bottom wall of the heat-insulating cylinder, and a sealing ring is provided on the outer wall of the supporting cylinder, and the sealing ring is engaged with the annular groove.

[0013] In one embodiment of the present application, the sealing cover includes a cover body and a sealing snap ring, wherein the cover body is detachably arranged on the supporting cylinder; the sealing snap ring is arranged on the bottom wall of the cover body, and the sealing snap ring is clamped with the top end of the insulation cylinder.

[0014] Additional aspects and advantages of the present application will be given in part in the description below, and in part will become apparent from the description below, or will be learned through practice of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The above and / or additional aspects and advantages of the present application will become apparent and easily understood from the following description of the embodiments in conjunction with the accompanying drawings, in which:

[0016] Figure 1 Schematic diagram of the structure of a stem cell storage device according to one embodiment of the present application;

[0017] Figure 2 is a schematic structural diagram of a stem cell storage device according to another embodiment of the present application;

[0018] Figure 3 FIG. 4 is a schematic structural diagram of a stem cell storage device according to another embodiment of the present application.

[0019] As shown in the figure: 10. Support frame; 20. Storage mechanism; 21. Support cylinder; 22. Test tube drag and drop component; 221. Test tube rack; 222. Support shaft; 211. Through groove; 212. Sealing ring; 2211. Dropping hole; 2212. Fixing hole; 2213. Protective gasket; 30. Sealing cover; 31. Cover body; 32. Sealing snap ring; 40. Driving mechanism; 50. Freezing mechanism; 51. Insulation cylinder; 52. Refrigeration pipe; 53. Sealing plug; 511. Annular groove; 512. Through hole; 513. Annular snap groove. DETAILED DESCRIPTION

[0020] The embodiments of the present application are described in detail below. Examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present application and are not to be construed as limiting the present application. On the contrary, the embodiments of the present application include all variations, modifications, and equivalents that fall within the spirit and scope of the appended claims.

[0021] The stem cell storage device according to an embodiment of the present application will be described below with reference to the accompanying drawings.

[0022] like Figure 1-Figure 3 As shown, the stem cell storage device according to the embodiment of the present application may include a support frame 10 , a storage mechanism 20 , a sealing cover 30 , a driving mechanism 40 and a freezing mechanism 50 .

[0023] The support frame 10 is vertically arranged relative to the ground, and the storage mechanism 20 is arranged on the support frame 10 . The storage mechanism 20 may include a support cylinder 21 and a plurality of test tube dragging and dropping components 22 .

[0024] The support cylinder 21 is detachably mounted on the support frame 10 and is provided with a plurality of through slots 211. It will be appreciated that the support cylinder 21 described in this embodiment is detachably mounted on the support frame 10 to facilitate installation and replacement of the support cylinder 21. For example, the support cylinder 21 can be connected to the support frame 10 using threaded fasteners such as screws, bolts, or bolts.

[0025] Multiple test tube dragging and dropping components 22 are respectively pivotally arranged in the through slot 211. For example, the multiple test tube dragging and dropping components 22 can be 6, 7, 8, 9, 10 test tube dragging and dropping components, etc. The specific number is not limited here. Among them, the test tube dragging and dropping components 22 are used to drag and drop test tubes containing stem cells.

[0026] The sealing cover 30 is detachably mounted on the support cylinder 21 to seal the opening at the upper end of the support cylinder 21. It will be appreciated that the sealing cover 30 described in this embodiment is detachably mounted on the support cylinder 21 to facilitate installation and replacement of the sealing cover 30. For example, the sealing cover 30 may be connected to the support cylinder 21 by means of a snap connection, a riveted connection, or a threaded fastener connection.

[0027] One end of the driving mechanism 40 is connected to the sealing cover 30, and the other end of the driving mechanism 40 is pivotally connected to the corresponding test tube drag and drop components 22 through multiple groups of first connecting rods (not specifically marked in the figure). For example, the multiple groups of first connecting rods can be 6, 7, 8, 9, 10 groups of first connecting rods, etc., each group of first connecting rods may include two first connecting rods, and the specific number is not limited here. The driving mechanism 40 is used to drive the test tube drag and drop component 22 to flip.

[0028] It should be noted that the driving mechanism 40 described in this embodiment can be a cylinder, the cylinder body of which is connected to the sealing cover 30, and the telescopic rod of the cylinder passes through the sealing cover 30 and is connected to the test tube dragging and dropping component 22 through multiple groups of first connecting rods.

[0029] In order to clearly illustrate the above embodiment, in one embodiment of the present application, as Figure 2 and Figure 3 As shown, the test tube dragging and dropping component 22 may include a test tube rack 221 and two supporting shafts 222 .

[0030] The test tube rack 221 is suspended within the through slot 211. A placement hole 2211 is provided at the top of the test tube rack 221, and a fixing hole 2212 is provided at the bottom of the test tube rack 221. Both sides of the top of the test tube rack 221 are pivotally connected to the other end of the drive mechanism 40 via a first connecting rod. It should be noted that the diameter of the placement hole 2211 described in this embodiment is larger than the diameter of the test tube, while the diameter of the fixing hole 2212 is smaller than the diameter of the test tube.

[0031] It should be noted that, in this embodiment, the height of one end of the first connecting rod connected to the driving mechanism 40 is higher than the height of the other end of the first connecting rod connected to the test tube rack 221 .

[0032] One end of the two support shafts 222 is fixedly connected to both sides of the bottom end of the test tube rack 221 , and the other end of the two support shafts 222 is pivotally connected to the inner wall of the through slot 211 .

[0033] Furthermore, in one embodiment of the present application, Figure 3 As shown, protective washers 2213 are respectively provided in the delivery hole 2211 and the fixing hole 2212 .

[0034] It can be understood that by providing protective gaskets 2213 in the injection hole 2211 and the fixing hole 2212 respectively, the test tube can be protected.

[0035] The freezing mechanism 50 is slidably arranged on the support cylinder 21, one end of the freezing mechanism 50 is sealedly connected to the support cylinder 21, and the other end of the freezing mechanism 50 is clamped with the sealing cover 30, and the freezing mechanism 50 is pivotally connected to the corresponding test tube drag and drop components 22 through multiple groups of second connecting rods (not specifically marked in the figure), wherein the test tube drag and drop components 22 are used to drive the freezing mechanism 50 to slide.

[0036] Specifically, when test tubes containing stem cells need to be stored, relevant staff first place the stem cell storage device at the location where the stem cells are to be stored (the location may be a cell storage room in a hospital, a biological storage room in a university, or a biological storage room in a research institute, etc.).

[0037] The staff then extends the telescopic rod of the control cylinder (drive mechanism 40). The telescopic rod pushes the top ends of the multiple test tube racks 221 to flip outward synchronously through multiple sets of first connecting rods. The flipped test tube racks 221 push the freezing mechanism 50 downward along the support cylinder 21 through multiple sets of second connecting rods. At this time, the freezing mechanism 50 pushes against the sealing cover 30, thereby exposing the test tube racks 221 sealed within the freezing mechanism 50. In other words, while the sealing cover 30 is controlled to open, the test tube racks 221 gradually extend the test tubes containing stem cells out of the freezing mechanism 50, making it easier for staff to remove and place the test tubes, effectively improving the retrieval efficiency.

[0038] When the test tube rack 221 is tilted to a preset angle (the preset angle can be any value between 30° and 60°, and the specific preset angle can be set according to the specific situation and is not specifically limited here), and the upper end of the test tube rack 211 is completely exposed, the cylinder stops working. (It will be understood that when the freezing mechanism is separated from the sealing cover 30, the test tube rack 221 is tilted and its release hole 2211 is exposed, and the staff can then directly remove the test tubes from the test tube rack 221. This can effectively improve the staff's work efficiency in removing and placing test tubes, greatly facilitating the staff's removal and placement of test tubes containing stem cells. The staff no longer needs to manually remove the test tube rack 221 containing the test tubes from the freezing mechanism 50 and then remove the test tubes from the test tube rack 221.)

[0039] Then, the staff places a plurality of test tubes containing stem cells on the corresponding test tube racks 221 one by one (that is, by passing the bottom end of the test tube through the delivery hole 2211 and extending it into the fixing hole 2212 for fixed placement). The staff then controls the telescopic rod of the cylinder to retract, and the retracted telescopic rod pulls the test tube rack 221 through the first connecting rod to gradually reverse and return to the initial position (the initial position is the position where the test tube rack 221 is vertically placed). At the same time, the reversed test tube rack 221 pulls the freezing mechanism 50 upward through the second connecting rod until the freezing mechanism 50 is engaged and sealed with the sealing cover 30. This achieves sealed frozen storage of the test tubes containing stem cells, effectively improving the work efficiency of the staff.

[0040] In one embodiment of the present application, Figure 1 and Figure 2 As shown, the freezing mechanism 50 may include a heat-insulating cylinder 51 , a refrigeration pipe 52 and two sealing plugs 53 .

[0041] Among them, the top end of the insulation cylinder 51 is clamped with the sealing cover 30, the bottom end of the insulation cylinder 51 is slidably connected to the support cylinder 21, and an annular groove 511 is provided in the cylinder wall of the insulation cylinder 51, and a plurality of through holes 512 connecting the annular groove 511 are provided on the inner wall of the insulation cylinder 51. The insulation cylinder 51 is pivotally connected to the two sides of the bottom end of the test tube rack 221 through a second connecting rod.

[0042] It should be noted that the length of the second connecting rod described in this embodiment is longer than the distance from the support shaft 222 to the pivotal connection point between the second connecting rod and the test tube rack 221. Specifically, the distance from the support shaft 222 to the pivotal connection point between the second connecting rod and the test tube rack 221, together with the second connecting rod and the heat-insulating cylinder 51, forms a slider-crank mechanism. For example, when the test tube rack 221 is tilted, the second connecting rod pushes the heat-insulating cylinder 51 to slide on the support cylinder 21.

[0043] The refrigeration pipe 52 is spirally wound within the annular groove 511, and the inlet and outlet ends of the refrigeration pipe 52 respectively penetrate the wall of the heat-insulating cylinder 51 and communicate with the outside. The refrigeration pipe 52 is used to hold a frozen liquid. It should be noted that the frozen liquid described in this embodiment can be liquid nitrogen or a frozen liquid.

[0044] It should be noted that the height of the inlet end of the refrigeration pipe 52 described in this embodiment is higher than that of the outlet end thereof.

[0045] Two sealing plugs 53 are respectively provided at the inlet and outlet ends of the refrigeration pipe 52 for sealing.

[0046] It is understandable that when it is necessary to freeze the test tube containing stem cells placed on the test tube rack 221, the relevant staff can introduce (pour) the freezing liquid into the refrigeration pipe 52 through the inlet end of the refrigeration pipe 52, and cool the inside of the insulation cylinder 51 through the refrigeration pipe 52. The cold air generated by the refrigeration pipe 52 enters the interior of the insulation cylinder 51 through the through hole 512 opened on the inner wall of the insulation cylinder 51, and freezes the stem cells in the test tube on the test tube rack 221.

[0047] As a possible scenario, to ensure a more sustained cooling effect in the refrigeration pipe 52, a refrigerator (not shown) may be provided, with the cold air outlet of the refrigerator connected to the inlet of the refrigeration pipe 52, and air holes (not shown) provided in the refrigeration pipe 52. It is understood that the cold air generated by the refrigerator is discharged into the refrigeration pipe 52, and then discharged through the air holes in the refrigeration pipe 52 into the interior of the insulation cylinder 51 to cool the test tube containing the stem cells.

[0048] Furthermore, in one embodiment of the present application, Figure 3 As shown, an annular groove 513 is provided on the bottom wall of the heat-insulating cylinder 51 , and a sealing ring 212 is provided on the outer wall of the supporting cylinder 21 , and the sealing ring 212 is engaged with the annular groove 513 .

[0049] It is understood that by providing the sealing ring 212 on the support cylinder 21 and engaging the sealing ring 212 with the annular groove 513 on the heat-insulating cylinder 51, the sealing effect between the heat-insulating cylinder 51 and the support cylinder 21 can be effectively enhanced, thereby preventing the refrigerated gas from escaping and affecting the refrigeration effect.

[0050] In one embodiment of the present application, Figure 3 As shown, the sealing cover 30 may include a cover body 31 and a sealing collar 32 .

[0051] The cover 31 is detachably disposed on the support cylinder 21 , the sealing clamp 32 is disposed on the bottom wall of the cover 31 , and the sealing clamp 32 is clamped with the top end of the heat-insulating cylinder 51 .

[0052] Specifically, when the insulation cylinder 51 slides upward along the support cylinder 21, the upper end of the insulation cylinder 51 gradually approaches the sealing clamp ring 32, and the annular groove 513 on the insulation cylinder 51 gradually approaches the sealing ring 212 on the support cylinder 21, until the upper end of the insulation cylinder 51 is stuck in the sealing clamp ring 32, and the annular groove 513 is stuck in the sealing ring 212, thereby achieving sealing of the insulation cylinder 51.

[0053] In summary, the stem cell storage device according to the embodiment of the present application has the advantage of convenient placement and removal of test tubes, and can effectively improve the work efficiency of staff.

[0054] In the description of this specification, the terms "first" and "second" are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of the technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include at least one of such features. In the description of this application, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0055] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present application. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner. In addition, those skilled in the art can combine and combine different embodiments or examples described in this specification and features of different embodiments or examples without contradiction.

[0056] Although the embodiments of the present application have been shown and described above, it can be understood that the above embodiments are exemplary and cannot be understood as limitations on the present application. Ordinary technicians in this field can change, modify, replace and deform the above embodiments within the scope of the present application.

Claims

1. A stem cell storage device, characterized in that: It includes a support frame, a storage mechanism, a sealing cover, a driving mechanism and a freezing mechanism, wherein: The support frame is arranged vertically relative to the ground; The storage mechanism is arranged on the support frame, and the storage mechanism includes a support cylinder and a plurality of test tube dragging and dropping components, wherein: The support cylinder is detachably arranged on the support frame, and a plurality of through slots are provided on the support cylinder; The plurality of test tube dragging and dropping components are respectively pivotally arranged in the through slots, wherein the test tube dragging and dropping components are used to drag and drop test tubes containing stem cells; The sealing cover is detachably arranged on the supporting cylinder; One end of the driving mechanism is connected to the sealing cover, and the other end of the driving mechanism is pivotally connected to the corresponding test tube dragging and dropping components through multiple groups of first connecting rods, wherein the driving mechanism is used to drive the test tube dragging and dropping components to flip; The freezing mechanism is slidably disposed on the supporting cylinder, one end of the freezing mechanism is sealedly connected to the supporting cylinder, the other end of the freezing mechanism is clamped with the sealing cover, and the freezing mechanism is pivotally connected to the corresponding test tube dragging and dropping components through multiple groups of second connecting rods, wherein the test tube dragging and dropping components are used to drive the freezing mechanism to slide; The test tube dragging and dropping component includes a test tube rack and two supporting shafts, wherein: The test tube rack is suspended in the through slot, a drop hole is provided at the top of the test tube rack, a fixing hole is provided at the bottom of the test tube rack, and both sides of the top of the test tube rack are pivotally connected to the other end of the driving mechanism via a first connecting rod; One end of the two support shafts is fixedly connected to both sides of the bottom end of the test tube rack, and the other ends of the two support shafts are pivotally connected to the inner walls of the through slot.

2. The stem cell storage device according to claim 1, characterized in that Protective washers are respectively provided in the delivery hole and the fixing hole.

3. The stem cell storage device according to claim 1, characterized in that The freezing mechanism includes a heat-insulating cylinder, a refrigeration pipe and two sealing plugs, wherein: The top end of the heat-insulating cylinder is clamped with the sealing cover, the bottom end of the heat-insulating cylinder is slidably connected to the supporting cylinder, and an annular groove is provided in the cylinder wall of the heat-insulating cylinder. A plurality of through holes communicating with the annular groove are provided on the inner wall of the heat-insulating cylinder, and the heat-insulating cylinder is pivotally connected to both sides of the bottom end of the test tube rack via a second connecting rod. The refrigeration pipe is spirally wound in the annular groove, and the inlet and outlet ends of the refrigeration pipe respectively penetrate the wall of the heat-insulating cylinder and communicate with the outside, wherein the refrigeration pipe is used to contain the refrigerated liquid; The two sealing plugs are respectively sealed at the inlet end and the outlet end of the refrigeration pipe.

4. The stem cell storage device according to claim 3, characterized in that An annular groove is provided on the bottom wall of the heat-insulating cylinder, and a sealing ring is provided on the outer wall of the supporting cylinder. The sealing ring is engaged with the annular groove.

5. The stem cell storage device according to claim 3, characterized in that The sealing cover includes a cover body and a sealing clamp ring, wherein: The cover body is detachably arranged on the supporting cylinder body; The sealing clamp ring is arranged on the bottom wall of the cover body, and the sealing clamp ring is clamped with the top end of the heat-insulating cylinder.

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