A fully automatic liquid-based cell slide preparation and staining machine

Abstract

The present application relates to a fully automatic liquid-based cell preparation and staining machine, which relates to the technical field of biomedical equipment; it includes a frame, a mounting rod is provided on the frame, and a plurality of placement slots for glass slides are provided along the length direction of the mounting rod, and a fixing piece is provided on the side wall of the mounting rod for fixing the plurality of glass slides to the inner walls of the corresponding placement slots, a movable slot is provided on the frame along the horizontal direction, a movable motor is provided on the inner wall of the movable slot, a movable screw rod is connected to the output end of the movable motor, a movable block is provided on the side wall of the movable screw rod, the movable block is slidably connected to the inner wall of the movable slot, a support hole is provided on the side of the movable block away from the mounting rod, a dyeing tube is provided on the inner wall of the support hole, a locking piece is provided between the dyeing tube and the movable block, and a liquid squeezing piece is provided on the movable block for pushing the dyeing liquid in the dyeing tube to move along the inner wall of the dyeing tube in a vertical direction; the present application has the effect of improving the work efficiency of the staff.

Description

Technical Field

[0001] The present application relates to the technical field of biomedical equipment, and in particular to a fully automatic liquid-based cell preparation and staining machine. Background Art

[0002] Liquid-based cytology smear technology is to adhere the useful cells to be diagnosed to the surface of the slide to form a layer of cell sheets on the slide. The cells in the cell sheets are neat and uniform, the single layer is flat, the background is clear, and there is no interference from red blood cells and mucus, which is convenient for diagnostic personnel to use in clinical diagnosis. Compared with the traditional cervical scraping Pap smear examination, liquid-based cytology examination can detect some precancerous lesions and microbial infections such as fungi, Trichomonas, viruses, and chlamydia.

[0003] After cell preparation, the cells usually need to be stained. Currently, the preparation operation and the staining operation are divided into two steps. When staining the cells, the prepared cells need to be moved to the staining area. The above operation reduces the work efficiency of the staff and needs to be improved. Summary of the Invention

[0004] In order to improve the work efficiency of staff, the present application provides a fully automatic liquid-based cell preparation and staining machine.

[0005] The present application provides a fully automatic liquid-based cell preparation and staining machine, which adopts the following technical solutions:

[0006] A fully automatic liquid-based cell slide staining machine comprises a frame, wherein the frame is provided with a mounting rod, the mounting rod is provided with a plurality of placement slots for placing slides along the length direction, the side wall of the mounting rod is provided with a fixing piece for fixing a plurality of slides to the inner walls of the corresponding placement slots, the frame is provided with a movable slot along the horizontal direction, the inner wall of the movable slot is provided with a movable motor, the output end of the movable motor is connected to a movable screw rod, the side wall of the movable screw rod is provided with a movable block, the movable block is slidably connected to the inner wall of the movable slot, a support hole is provided on the side of the movable block away from the mounting rod, a dyeing tube is provided on the inner wall of the support hole, a locking piece is provided between the dyeing tube and the movable block, and a liquid squeezing piece is provided on the movable block for pushing the dyeing liquid in the dyeing tube to move along the inner wall of the dyeing tube in a vertical direction.

[0007] By adopting the above technical solution, the slide is placed on the inner wall of the placement groove, and then cell preparation is carried out. After the cell preparation is completed, the moving motor is started, and the moving motor drives the moving screw to rotate, and the moving screw drives the moving block to move in the horizontal direction until the moving block moves to the top of the placement groove where the slide is placed, and then the liquid extrusion part drives the dyeing liquid in the dyeing tube to move in the vertical direction, so that the dyeing liquid in the dyeing tube drips onto the slide placed on the inner wall of the placement groove, thereby staining the cells on the slide, effectively improving the work efficiency of the staff.

[0008] Preferably, the locking member includes a positioning plate, a first plug rod, a first locking threaded rod, a second plug rod, a second locking threaded rod and a locking tube, the dye tube is arranged on the inner wall of the positioning plate, the first plug rod is arranged on the side of the positioning plate close to the moving block, the first locking threaded rod is rotatably connected to one end of the first plug rod away from the positioning plate, the second plug rod is arranged on the side of the positioning plate close to the moving block, and the second locking thread is rotatably connected to one end of the second plug rod away from the positioning plate. The side wall of the positioning plate is vertically penetrated by a first locking hole for inserting the first plug rod and the first locking threaded rod, and the side wall of the positioning plate is vertically penetrated by a second locking hole for inserting the second plug rod and the second locking threaded rod. One end of the locking tube is threadedly sleeved on the side wall of the first locking threaded rod, and the other end of the locking tube is threadedly sleeved on the side wall of the second locking threaded rod, and the thread rotation direction of the outer side walls of the first locking threaded rod and the second locking threaded rod is the same.

[0009] By adopting the above technical solution, after the positioning plate and the moving block are close to each other, the first locking threaded rod and the first insertion rod pass through the inner wall of the first locking hole in sequence, and the second locking threaded rod and the second insertion rod pass through the inner wall of the second locking hole in sequence, and then the locking tube is threadedly sleeved on the first locking screw, and the first locking threaded rod and the second locking threaded rod are rotated toward the side close to each other, and finally the locking tube is rotated until one end of the locking tube is threadedly sleeved on the first locking screw and the other end is threadedly sleeved on the second locking screw, thereby fixing the first locking threaded rod and the second locking threaded rod, and then fixing the positioning plate and the sliding block, so that the dyeing tube can be replaced when the dyeing liquid in the dyeing tube is used up.

[0010] Preferably, the fixing member includes a fixing plate, a dovetail block and an elastic member, the fixing plate is arranged on the side wall of the dovetail block, the side wall of the mounting rod is provided with a dovetail groove for the dovetail block to slide in the horizontal direction, one end of the elastic member is arranged on the bottom wall of the dovetail groove, and the other end of the elastic member is arranged on the side wall of the dovetail block.

[0011] By adopting the above technical solution, when glass slides are placed on the corresponding inner walls of several placement grooves, the dovetail block moves along the vertical direction of the inner wall of the dovetail groove under the action of the elastic member, and the dovetail block simultaneously drives the fixed plate to move along the vertical direction until the fixed plate abuts against the side wall of the mounting rod, thereby improving the stability of the glass slide embedded in the inner wall of the placement groove.

[0012] Preferably, the fixing member further includes a protection pad, which is arranged on a side of the fixing plate close to the mounting rod.

[0013] By adopting the above technical solution and providing the protective pad, the possibility of the glass slide being worn due to contact between the fixing plate and the glass slide when the fixing plate directly abuts the side wall of the mounting rod is reduced.

[0014] Preferably, a support frame is provided on the inner wall of each placement slot, and a drainage tube is provided on each support frame.

[0015] By adopting the above technical solution and setting up the drainage tube, the possibility of the dyeing liquid splashing around under its own gravity when the dyeing tube injects the dyeing liquid onto the slide placed on the inner wall of the placement tank is reduced, thereby effectively improving the work efficiency of the staff.

[0016] Preferably, a sliding groove is provided on the upper surface of the frame in the horizontal direction, a driving motor is provided on the inner wall of the sliding groove, the output end of the driving motor is connected to a driving screw, a sliding frame is provided on the side wall of the driving screw, a rotating part is provided between the sliding frame and the mounting rod to drive the mounting rod to rotate, and a liquid collecting bucket for collecting excess dyeing liquid in the drainage tube is provided on one side of the frame.

[0017] By adopting the above technical solution, the drive motor is started, the drive motor drives the drive screw to rotate, and the drive screw drives the sliding frame to rotate in the horizontal direction. When the sliding block moves close to the liquid collecting barrel, the rotating part drives the mounting rod to rotate, thereby causing the mounting rod to rotate, and then the excess dyeing liquid in the drainage tube is collected through the liquid collecting barrel.

[0018] Preferably, the rotating member includes a rotating rod, a fixed cover, and a rotating block. The rotating rod is arranged on the side wall of the mounting rod, the rotating rod is rotatably connected to the inside of the sliding frame, the fixed cover is arranged on the frame, and the rotating block is arranged on the side wall of the rotating rod. A connecting groove for the rotating rod to move horizontally is provided on the side of the fixed cover close to the frame, and a rotating groove for the rotating rod to rotate and slide is provided on the side of the fixed cover close to the frame. The connecting groove and the rotating groove are communicated with each other, and the rotating block is slidably connected to the inner wall of the connecting groove and the inner wall of the rotating groove.

[0019] By adopting the above technical solution, when the sliding frame moves horizontally along the inner wall of the sliding groove, the rotating block moves synchronously along the horizontal direction of the inner wall of the connecting groove. When the rotating block moves along the inner wall of the rotating groove, the rotating rod rotates synchronously along the sliding frame. The rotating rod drives the mounting rod to rotate synchronously, so that the mounting rod rotates to the top of the liquid collecting barrel, thereby pouring the excess dyeing liquid in the drainage tube into the inner wall of the liquid collecting barrel, thereby facilitating the collection of excess dyeing liquid in the drainage tube.

[0020] Preferably, a rolling ball is provided at one end of the rotating block away from the rotating rod.

[0021] By adopting the above technical solution and setting the rolling ball, the wear generated when the rotating block moves along the inner wall of the connecting groove and the inner wall of the rotating groove is reduced, thereby extending the service life of the rotating block.

[0022] Preferably, the side wall of the liquid collecting barrel is provided with a shielding plate, and the shielding plate is provided with a liquid pushing member.

[0023] By adopting the above technical solution and setting the baffle, the possibility of the dyeing liquid in the drainage tube splashing when the mounting rod is flipped is reduced, so that the staff does not need to clean the splashed dyeing liquid, which effectively improves the work efficiency of the staff.

[0024] Preferably, the liquid pushing part includes a pushing cylinder, a docking block and a liquid pushing rod, the pushing cylinder is arranged on the side wall of the liquid collecting barrel, one end of the pushing cylinder piston rod is connected to the docking block, the liquid pushing rod is arranged on the side wall of the docking block, and the liquid pushing rod is slidably connected to the side wall of the baffle.

[0025] By adopting the above technical solution, the cylinder drives the docking block to move in the vertical direction, and the docking block synchronously drives the liquid pushing rod to move in the vertical direction, so that the dyeing liquid on the shielding plate is cleaned by the pushing rod, reducing the possibility of a large amount of dyeing liquid accumulating on the shielding plate.

[0026] In summary, this application includes at least one of the following beneficial technical effects:

[0027] 1. The slide is placed on the inner wall of the placement tank, and then cell preparation is carried out. After the cell preparation is completed, the moving motor is started, and the moving motor drives the moving screw to rotate, and the moving screw drives the moving block to move in the horizontal direction until the moving block moves to the top of the placement tank where the slide is placed. Then, the liquid extruder drives the dyeing liquid in the dyeing tube to move in the vertical direction, so that the dyeing liquid in the dyeing tube drips onto the slide placed on the inner wall of the placement tank, thereby staining the cells on the slide, effectively improving the work efficiency of the staff.

[0028] 2. Start the drive motor, which drives the drive screw to rotate, and the drive screw drives the sliding frame to rotate horizontally. When the sliding block moves close to the liquid collection barrel, the rotating member drives the mounting rod to rotate, thereby causing the mounting rod to rotate, and then the excess dye in the drainage tube is collected through the liquid collection barrel. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a schematic diagram of the overall structure of a fully automatic liquid-based cell preparation and staining machine in an embodiment of the present application.

[0030] Figure 2 yes Figure 1 A magnified view of the structure in center A.

[0031] Figure 3 It is a cross-sectional view used to illustrate the dyeing tube structure in the embodiment of the present application.

[0032] Figure 4 It is a cross-sectional view used to illustrate the locking structure in the embodiment of the present application.

[0033] Figure 5 It is a cross-sectional view used to illustrate the structure of the fixing member in the embodiment of the present application.

[0034] Figure 6 It is a cross-sectional view used to illustrate the structure of the rotating part in the embodiment of the present application.

[0035] Figure 7 It is a schematic diagram used to illustrate the internal structure of the fixed cover in the embodiment of the present application.

[0036] Description of reference numerals:

[0037] 1. Frame; 11. Moving slot; 111. Moving motor; 112. Moving screw; 12. Sliding slot; 121. Driving motor; 122. Driving screw; 123. Sliding rack; 2. Mounting rod; 21. Placement slot; 211. Support frame; 212. Drainage tube; 22. Dovetail slot; 3. Fixing element; 31. Fixing plate; 32. Dovetail block; 33. Elastic element; 34. Protective pad; 4. Moving block; 41. Support hole; 42. Extrusion element; 421. Connecting rod; 4211. Connecting slot; 422. Extrusion motor; 423. Extrusion screw; 424. Extrusion block; 5. Dyeing tube; 51. Tube body; 52. Sealing plate; 53. Extruding rod; 6. Locking member; 61. Positioning plate; 611. First locking hole; 612. Second locking hole; 62. First plug rod; 63. First locking threaded rod; 64. Second plug rod; 65. Second locking threaded rod; 66. Locking tube; 7. Rotating member; 71. Rotating rod; 72. Fixed cover; 721. Connecting groove; 722. Rotating groove; 73. Rotating block; 731. Rolling ball; 8. Liquid collecting barrel; 81. Shielding plate; 9. Liquid pushing member; 91. Pushing cylinder; 92. Docking block; 93. Liquid pushing rod. DETAILED DESCRIPTION

[0038] The following is combined with Figure 1-7 This application is described in further detail.

[0039] The present application embodiment discloses a fully automatic liquid-based cell preparation and staining machine. Figure 1 and Figure 2The dyeing machine includes a frame 1, a movable groove 11 is opened on the frame 1 in the horizontal direction, and a movable motor 111 is connected to the inner wall of the movable groove 11 by bolts. The output end of the movable motor 111 is connected to a movable screw 112, and the other end of the movable screw 112 away from the movable motor 111 is rotatably connected to the inner wall of the movable groove 11. The side wall of the movable screw 112 is sleeved with a movable block 4, and the movable block 4 is slidably connected to the inner wall of the movable groove 11; a support hole 41 is opened through the side wall of the movable block 4 in the vertical direction, and a dyeing tube 5 is set on the inner wall of the support hole 41. A locking member 6 is set between the dyeing tube 5 and the movable block 4 so that the dyeing liquid in the dyeing tube 5 can be replaced after use. A liquid squeezing member 42 is set on the upper surface of the movable block 4 so that the dyeing liquid in the dyeing tube 5 can be pushed to move in the vertical direction with the help of the liquid squeezing member 42.

[0040] Reference Figure 1 A mounting rod 2 is provided on the frame 1, and a plurality of placement slots 21 for placing glass slides are opened on the side wall of the mounting rod 2 in the horizontal direction. A fixing member 3 is provided on the side wall of the mounting rod 2 for fixing a plurality of glass slides to the inner wall of the corresponding placement slot 21.

[0041] Reference Figure 1 and Figure 2 , place the glass slide on the inner wall of the placement groove 21, so that the glass slide performs product operation on the cells; then start the moving motor 111, the moving motor 111 drives the moving screw 112 to rotate, and the moving screw 112 drives the moving block 4 to move in the horizontal direction, so that the moving block 4 is located above the placement groove 21 where the glass slide is placed; finally, the dyeing liquid in the dyeing tube 5 is driven by the liquid extrusion part 42 to move toward the side of the mounting rod 2, so that the dyeing liquid in the dyeing tube 5 drips onto the glass slide, thereby staining the cells on the glass slide, effectively improving the work efficiency of the staff.

[0042] Reference Figure 3 The dyeing tube 5 includes a tube body 51, a sealing plate 52 and a squeezing rod 53. The tube body 51 is inserted into the inner wall of the support hole 41; the sealing plate 52 can be made of rubber, and the sealing plate 52 is slidably connected to the inside of the tube body 51. The squeezing rod 53 is glued to the side of the sealing plate 52 away from the mounting rod 2 by glue.

[0043] Reference Figure 2The extrusion component 42 includes a connecting rod 421, an extrusion motor 422, an extrusion screw 423 and an extrusion block 424; a connecting groove 4211 is opened on the side wall of the connecting rod 421 in the vertical direction, the extrusion motor 422 is connected to the inner wall of the connecting groove 4211 by bolts, the extrusion screw 423 is connected to the output end of the extrusion motor 422, and the end of the extrusion screw 423 away from the extrusion motor 422 is rotatably connected to the inner wall of the connecting groove 4211, the extrusion block 424 is threadedly sleeved on the extrusion screw 423, and the extrusion block 424 is slidably connected to the inner wall of the connecting groove 4211, and the extrusion block 424 and the extrusion rod 53 are connected by bolts. So that the staff can start the extrusion motor 422, the extrusion motor 422 drives the extrusion screw 423 to rotate, and the extrusion screw 423 drives the extrusion block 424 to move in the vertical direction; the extrusion block 424 drives the extrusion rod 53 to move in the vertical direction, and the extrusion rod 53 synchronously drives the sealing plate 52 to move in the vertical direction, thereby squeezing the dyeing liquid in the tube body 51.

[0044] Reference Figure 4 The locking member 6 includes a positioning plate 61, a first insertion rod 62, a first locking threaded rod 63, a second insertion rod 64, a second locking threaded rod 65, and a locking tube 66. The dye tube 5 is embedded in the inner wall of the positioning plate 61 by glue. The first insertion rod 62 is welded to the side of the positioning plate 61 close to the movable block 4. The first locking threaded rod 63 is rotatably connected to the end of the first insertion rod 62 away from the positioning plate 61. The side wall of the positioning plate 61 is vertically penetrated with a first locking hole 611 for the first insertion rod 62 and the first locking threaded rod 63 to pass through in sequence. The second locking threaded rod 65 is rotatably connected to the end of the second insertion rod 64 away from the positioning plate 61. The side wall of the positioning plate 61 is vertically penetrated with a second locking hole 612 for the second insertion rod 64 and the second locking threaded rod 65 to be inserted in sequence. One end of the locking tube 66 is threadedly sleeved on the side wall of the first locking threaded rod 63, and the other end of the locking tube 66 is threadedly sleeved on the side wall of the second locking threaded rod 65. The thread rotation direction of the side walls of the first locking threaded rod 63 and the second locking threaded rod 65 is the same.

[0045] Reference Figure 4 When the dyeing liquid in the dyeing tube 5 is used up, the locking tube 66 is rotated so that the locking tube 66 is completely threadedly sleeved on the first locking threaded rod 63. At this time, the locking tube 66 is disengaged from the second locking threaded rod 65; then the first locking threaded rod 63 and the second locking threaded rod 65 are rotated toward the side away from each other, and then the locking tube 66 is threadedly disengaged from the side wall of the first locking threaded rod 63; finally, the first insertion rod 62 and the first locking threaded rod 63 are disengaged from the inner wall of the first locking hole 611 in turn, and the second insertion rod 64 and the second locking threaded rod 65 are disengaged from the inner wall of the second locking hole 612 in turn, so that the positioning plate 61 and the moving block 4 are disengaged from each other, thereby facilitating the staff to replace the dyeing tube 5 without residual dyeing liquid.

[0046] Reference Figure 5 The fixing member 3 includes a fixing plate 31, a dovetail block 32, an elastic member 33 and a protective pad 34. The fixing plate 31 can be an L-shaped rod. The dovetail block 32 is welded to the side wall of the fixing plate 31. The side wall of the mounting rod 2 is provided with a dovetail groove 22 for the dovetail block 32 to slide in the vertical direction. The elastic member 33 can be a spring. One end of the elastic member 33 is welded to the side wall of the dovetail block 32, and the other end of the elastic member 33 is welded to the bottom wall of the dovetail groove 22; the protective pad 34 can be made of rubber, and the protective pad 34 is glued to the side of the fixing plate 31 close to the mounting rod 2 by glue. When the glass slides located on the inner walls of the several placement grooves 21 are stained, the fixing plate 31 is moved vertically toward the side away from the staining tube 5, and the fixing plate 31 drives the dovetail block 32 to move synchronously toward the side of the bottom wall of the dovetail groove 22. At this time, the elastic member 33 is compressed, so that the fixing plate 31 is separated from the abutment against the notches of the several placement grooves 21, thereby facilitating the removal of the stained glass slides from the inner wall of the placement groove 21.

[0047] Reference Figure 5 A support frame 211 is welded to the inner wall of each placement groove 21, and a drainage tube 212 is welded to the inner wall of each support frame 211, so that the dyeing liquid in the dyeing tube 5 can be concentrated and dripped onto the slide, reducing the possibility of the dyeing liquid splashing everywhere, thereby improving the work efficiency of the staff.

[0048] Reference Figure 6 and Figure 7 The upper surface of the frame 1 is provided with a sliding groove 12 in the horizontal direction. The inner wall of the sliding groove 12 is connected to a drive motor 121 by bolts. The output end of the drive motor 121 is connected to a drive screw 122. The side wall of the drive screw 122 is threadedly sleeved with a sliding frame 123. A rotating member 7 is provided between the sliding frame 123 and the mounting rod 2. The rotating member 7 includes a rotating rod 71, a fixed cover 72, and a rotating block 73. The rotating rod 71 is welded to the end of the mounting rod 2 near the sliding frame 123. The rotating rod 71 is rotatably connected to the inside of the sliding frame 123. The fixed cover 72 is welded to the frame 1. The rotating block 73 is welded to the side wall of the rotating rod 71. The side of the fixed cover 72 near the frame 1 is provided with a connecting groove 721 for the rotating block 73 to move horizontally. The side of the fixed cover 72 near the frame 1 is provided with a rotating groove 722 for the rotating block 73 to rotate. The connecting groove 721 and the rotating groove 722 are connected. A liquid collecting barrel 8 is welded to the side wall of the frame 1.

[0049] Reference Figure 6, when the staining liquid has been standing in the drainage tube 212 for a period of time, the staining of the slide is completed; start the drive motor 121, the drive motor 121 drives the drive screw 122 to rotate, the drive screw 122 drives the sliding frame 123 to move in the horizontal direction, the rotating rod 71 moves synchronously in the horizontal direction, and the rotating rod 71 synchronously drives the rotating block 73 to move in the horizontal direction along the inner wall of the connecting groove 721; when the rotating block 73 moves from the inner wall of the connecting groove 721 to the inner wall of the rotating groove 722 and moves along the inner wall of the rotating groove 722, the rotating block 73 synchronously drives the rotating rod 71 to rotate along the inner wall of the sliding frame 123, and the rotating rod 71 synchronously drives the mounting rod 2 to rotate, so that the several drainage tubes 212 are flipped, so that the excess staining liquid in the drainage tube 212 can be poured into the liquid collecting bucket 8 for collection.

[0050] Reference Figure 6 A rolling ball 731 is integrally formed at one end of the rotating block 73 away from the rotating rod 71, which effectively reduces the wear caused by the rotating block 73 moving along the inner wall of the connecting groove 721 and the inner wall of the rotating groove 722, thereby extending the service life of the rotating block 73.

[0051] Reference Figure 6 A shielding plate 81 is welded on the side of the liquid collecting barrel 8 away from the frame 1 , and a liquid pushing member 9 is provided on the shielding plate 81 . The liquid pushing part 9 includes a pushing cylinder 91, a docking block 92 and a pushing rod 93. The pushing cylinder 91 is connected to the side wall of the baffle 81 by bolts, and one end of the piston rod of the pushing cylinder 91 is connected to the docking block 92. The pushing rod 93 is welded to the side wall of the docking block 92, and the pushing rod 93 is slidably connected to the baffle 81; when the mounting rod 2 flips and rotates, the dyeing liquid remaining in the drainage tube 212 may spray onto the baffle 81; then the pushing cylinder 91 is started, and the pushing cylinder 91 drives the docking block 92 to move in the vertical direction, and the docking block 92 drives the pushing rod 93 to move in the vertical direction, thereby pushing the dyeing liquid remaining on the baffle 81, reducing the possibility that the remaining dyeing liquid on the baffle 81 moves in the vertical direction under the action of its own gravity and falls to the ground, thereby effectively improving the work efficiency of the staff.

[0052] The working principle of the fully automatic liquid-based cell preparation and staining machine of the embodiment of the present application is as follows: a slide is placed on the inner wall of the placement groove 21, and then the fixing plate 31 is loosened. The elastic force of the elastic member 33 drives the fixing plate 31 to move in the vertical direction, so that the protective pad 34 abuts against the slide on the inner wall of the placement groove 21; then the cell preparation operation is performed. After the cell preparation is completed, the moving motor 111 is started, and the moving motor 111 drives the moving screw 112 to rotate, and the moving screw 112 drives the moving block 4 to move in the horizontal direction, so that the moving block 4 moves to the placement groove 21. There is a slide placement slot 21 above; finally, by starting the liquid squeezing motor 422, the liquid squeezing motor 422 drives the liquid squeezing screw 423 to rotate, the liquid squeezing screw 423 drives the liquid squeezing block 424 to move in the vertical direction, the liquid squeezing block 424 drives the liquid squeezing rod 53 to move in the vertical direction, and the liquid squeezing rod 53 synchronously drives the sealing plate 52 to move in the vertical direction, thereby squeezing the dye in the dye tube 5, so that the dye in the dye tube 5 drips onto the slide, thereby staining the cells on the slide, effectively improving the work efficiency of the staff.

[0053] The above are all preferred embodiments of the present application, and are not intended to limit the scope of protection of the present application. Therefore, any equivalent changes made based on the structure, shape, and principle of the present application should be included in the scope of protection of the present application.

Claims

1. A fully automatic liquid-based cell preparation and staining machine, comprising a frame (1), characterized in that: The frame (1) is provided with a mounting rod (2), and the mounting rod (2) is provided with a plurality of placement grooves (21) for placing glass slides along the length direction. The side wall of the mounting rod (2) is provided with a fixing member (3) for fixing the plurality of glass slides to the inner wall of the corresponding placement groove (21). The frame (1) is provided with a moving groove (11) along the horizontal direction. The inner wall of the moving groove (11) is provided with a moving motor (111). The output end of the moving motor (111) is connected to a moving screw rod (112). The side wall of the moving screw rod (112) is provided with a moving block (4). The moving block (4) is slidably connected to the inner wall of the moving groove (11). A support hole (41) is provided on a side of the moving block (4) away from the mounting rod (2); a dye tube (5) is provided on the inner wall of the support hole (41); a locking member (6) is provided between the dye tube (5) and the moving block (4); and a liquid extrusion member (42) is provided on the moving block (4) for pushing the dye liquid in the dye tube (5) to move along the inner wall of the dye tube (5) in a vertical direction; the moving motor (111) is started, the moving motor (111) drives the moving screw (112) to rotate, and the moving screw (112) drives the moving block (4) to move in a horizontal direction, so that the moving block (4) is located above the placement groove (21) on which the slide is placed.

2. A fully automatic liquid-based cell slide staining machine according to claim 1, characterized in that: The locking member (6) includes a positioning plate (61), a first plug rod (62), a first locking threaded rod (63), a second plug rod (64), a second locking threaded rod (65) and a locking tube (66); the dyeing tube (5) is arranged on the inner wall of the positioning plate (61); the first plug rod (62) is arranged on the side of the positioning plate (61) close to the moving block (4); the first locking threaded rod (63) is rotatably connected to an end of the first plug rod (62) away from the positioning plate (61); the second plug rod (64) is arranged on the side of the positioning plate (61) close to the moving block (4); the second locking threaded rod (65) is rotatably connected to the second plug rod (64) away from the positioning plate (61), a first locking hole (611) for inserting a first insertion rod (62) and a first locking threaded rod (63) is provided on the side wall of the positioning plate (61) in a vertical direction, and a second locking hole (612) for inserting a second insertion rod (64) and a second locking threaded rod (65) is provided on the side wall of the positioning plate (61) in a vertical direction, one end of the locking tube (66) is threadedly sleeved on the side wall of the first locking threaded rod (63), and the other end of the locking tube (66) is threadedly sleeved on the side wall of the second locking threaded rod (65), and the thread rotation direction of the outer side walls of the first locking threaded rod (63) and the second locking threaded rod (65) is the same.

3. The fully automatic liquid-based cell slide staining machine according to claim 1, characterized in that: The fixing member (3) includes a fixing plate (31), a dovetail block (32) and an elastic member (33); the fixing plate (31) is arranged on the side wall of the dovetail block (32); the side wall of the mounting rod (2) is provided with a dovetail groove (22) for the dovetail block (32) to slide in the vertical direction; one end of the elastic member (33) is arranged on the bottom wall of the dovetail groove (22); and the other end of the elastic member (33) is arranged on the side wall of the dovetail block (32).

4. The fully automatic liquid-based cell slide staining machine according to claim 3, characterized in that: The fixing member (3) further comprises a protection pad (34), and the protection pad (34) is arranged on a side of the fixing plate (31) close to the mounting rod (2).

5. The fully automatic liquid-based cell preparation and staining machine according to claim 1, characterized in that: A support frame (211) is provided on the inner wall of each placement groove (21), and a drainage tube (212) is provided on each support frame (211).

6. The fully automatic liquid-based cell slide staining machine according to claim 5, characterized in that: The upper surface of the frame (1) is provided with a sliding groove (12) in the horizontal direction, the inner wall of the sliding groove (12) is provided with a driving motor (121), the output end of the driving motor (121) is connected to a driving screw rod (122), the side wall of the driving screw rod (122) is provided with a sliding frame (123), a rotating member (7) is provided between the sliding frame (123) and the mounting rod (2) for driving the mounting rod (2) to rotate, and a liquid collecting bucket (8) for collecting excess dyeing liquid in the drainage tube (212) is provided on one side of the frame (1).

7. The fully automatic liquid-based cell slide staining machine according to claim 6, characterized in that: The rotating member (7) comprises a rotating rod (71), a fixed cover (72), and a rotating block (73). The rotating rod (71) is arranged at one end of the mounting rod (2) away from the fixed plate (31). The rotating rod (71) is rotatably connected to the inside of the sliding frame (123). The fixed cover (72) is arranged on the frame (1). The rotating block (73) is arranged on the side wall of the rotating rod (71). The inner wall of the fixed cover (72) is provided with a connecting groove (721) for the rotating rod (71) to move horizontally. The inner wall of the fixed cover (72) is provided with a rotating groove (722) for the rotating rod (71) to rotate. The connecting groove (721) and the rotating groove (722) are communicated with each other. The rotating block (73) is slidably connected to the inner wall of the connecting groove (721) and the inner wall of the rotating groove (722).

8. The fully automatic liquid-based cell slide staining machine according to claim 7, characterized in that: A rolling ball (731) is provided at one end of the rotating block (73) away from the rotating rod (71).

9. The fully automatic liquid-based cell slide staining machine according to claim 6, characterized in that: The side wall of the liquid collecting barrel (8) is provided with a shielding plate (81), and the shielding plate (81) is provided with a liquid pushing member (9).

10. The fully automatic liquid-based cell slide preparation and staining machine according to claim 9, characterized in that: The liquid pushing member (9) comprises a pushing cylinder (91), a docking block (92) and a liquid pushing rod (93); the pushing cylinder (91) is arranged on the side wall of the liquid collecting barrel (8); one end of the piston rod of the pushing cylinder (91) is connected to the docking block (92); the liquid pushing rod (93) is arranged on the side wall of the docking block (92); and the liquid pushing rod (93) is slidably connected to the side wall of the shielding plate (81).

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