Raw liquid processing device and operating method of raw liquid processing device

Abstract

The present invention provides a raw liquid treatment device and an operation method of the raw liquid treatment device, which can easily perform leakage inspection, and the air exhaust operation is also relatively easy, and the flow path can be effectively cleaned. In the operation method of the raw liquid treatment device (1), the raw liquid treatment device (1) comprises: a filter (10), which has a filter component that can filter raw liquids such as pleural effusion or plasma but cannot pass gas; a concentrator (20), which is supplied with filtrate filtered by the filter (10) and concentrates the filtrate to form a concentrated liquid, and the filter (10) comprises: a main body (11), which has an internal space isolated by the flow path for supplying raw liquid and the filter component; a port, which connects the internal space of the main body (11) with the outside, and in a state where the internal space of the main body (11) is airtightly isolated from the outside, pressurized gas is supplied to the internal space from the port, thereby measuring the pressure of the gas in the internal space.

Description

[0001] This invention application is a divisional application filed based on the Chinese invention application that entered the Chinese national phase based on the international application with PCT application number PCT / JP2018 / 019412 of the National University Corporation Tokushima University and Takatori Co., Ltd., and the subject matter of which is “Raw liquid treatment device and operating method of raw liquid treatment device”. The application number of the Chinese invention application is 201880032617.8, and the application date is May 18, 2018. Technical Field

[0002] The present invention relates to a raw liquid treatment device and an operating method thereof. More specifically, it relates to a raw liquid treatment device for obtaining a treated liquid for intravenous infusion by filtering or concentrating raw liquids such as pleural effusion accumulated in the chest or abdomen in carcinomatous pleuroperitoneitis, liver cirrhosis, etc., and waste plasma in plasma exchange therapy. Background Art

[0003] In cancerous pleuroperitoneitis, liver cirrhosis, etc., pleural effusion or peritoneal effusion may accumulate in the pleural cavity or abdominal cavity. When such pleural effusion accumulates, the pleural effusion may compress the surrounding internal organs. In order to improve such problems, pleural effusion may be extracted by puncture.

[0004] On the other hand, the pleural and abdominal effusion contains part or all of the plasma components exuded from the blood, and the plasma contains major proteins (e.g., albumin, globulin, etc.). Although the above symptoms can be improved by extracting the pleural and abdominal effusion, components useful to the human body such as protein will be lost along with water. Therefore, it is necessary to administer albumin preparations, globulin preparations, etc. intravenously to replenish the lost components.

[0005] However, although specific components can be supplemented by intravenously administering albumin preparations, globulin preparations, etc., the preparations are expensive, and the cost of treatment becomes very high.

[0006] Furthermore, since only a limited amount of specific components among the lost components can be supplied, there is a possibility of problems such as nutritional deficiencies and susceptibility to infection.

[0007] Therefore, a treatment method has been developed in which the treated fluid extracted from the pleural effusion or peritoneal effusion is administered intravenously, namely the so-called Cell-free and Concentrated Ascites Reinfusion Therapy (CART). In the case of such CART, most of the effective ingredients other than the cellular components contained in the pleural effusion and peritoneal effusion can be returned to the patient's body, so it is possible to effectively supply the patient with the components lost from the blood without being limited to specific components. Moreover, even if the concentrated solution is administered, as long as the insufficient components are supplemented by the preparation in a manner corresponding to the insufficient amount, the use of albumin preparations, etc. can be reduced as much as possible, thereby suppressing the cost of treatment.

[0008] In CART, a treatment fluid is generated by filtering and concentrating pleural effusion or peritoneal effusion to generate a treatment fluid that is returned to the patient's body. In a treatment device that generates such a treatment fluid, a raw fluid such as pleural effusion or peritoneal effusion is supplied to a filter having a filtration component such as a hollow fiber membrane or a plate-shaped permeable membrane to separate the liquid component (hereinafter sometimes referred to as the filtrate). If the separated filtrate is passed through a concentrator to remove water from the filtrate, a concentrated solution after concentrating the filtrate can be obtained, that is, the above-mentioned treatment fluid (see patent documents 1 and 2).

[0009] However, when the stock solution is filtered through the filter element in the filter, if there is a defect in the filter element, the stock solution cannot be properly filtered, and cell components that should not be included in the treatment solution may be mixed into the filtrate. In order to prevent such a situation where cell components are included in the filtrate, the filter element of the filter is checked for damage before using the filter to treat the stock solution.

[0010] Since the filter component of the filter used in CART uses a component that gas cannot pass through, pressurized gas is supplied to the filter to confirm whether the filter component is damaged (leakage check). After the filter is installed in the processing device, the leakage check is implemented as follows. First, in the two ports in the filter that are connected to the flow path for supplying the stock solution, etc. (or the flow path connected to the two ports), one of the ports is closed. In this state, pressurized gas is supplied from the other port, and the air pressure in the flow path is measured via the port, etc. If the air pressure in the flow path reaches a specified pressure, the other port is also closed to confirm the change of the air pressure in the flow path. Then, when the air pressure does not change within a certain period of time, it is judged that the filter component is not damaged, and when the change of the air pressure is observed, it is judged that the filter component is damaged.

[0011] Prior art literature

[0012] Patent Literature

[0013] Patent Document 1: Japanese Patent No. 5062631

[0014] Patent Document 2: Japanese Patent Application Publication No. 2015-126763 Summary of the invention

[0015] Technical problem to be solved by the invention

[0016] In the treatment device, the path from the bag containing the stock solution (stock solution bag) to the bag containing the treatment solution (concentrated solution bag) must be kept isolated from the outside so as not to come into contact with the air, etc. Therefore, when cleaning the flow path (hereinafter referred to as the circuit) through which the stock solution, etc. flows in the treatment device after a leak check, it is necessary to discharge the air in the circuit, especially the air in the flow path (stock solution flow path) through which the stock solution, etc. is supplied in the filter, with a cleaning fluid.

[0017] However, since the raw liquid flow path of the filter is very narrow, it takes a long time to reliably discharge the air from the raw liquid flow path, and a large amount of cleaning liquid must be used to reliably discharge the air.

[0018] In addition, in the treatment device, the filter components are sometimes cleaned after the stock solution is treated. In this case, the cleaning is usually performed by backwashing as described in Patent Document 2. Backwashing refers to cleaning the filter components and the like in the filter by flowing the cleaning liquid in the opposite direction to the flow of the solution during filtration or concentration.

[0019] In such backwashing, since the cleaning liquid must flow in the entire circuit or in the entire flow path for the stock liquid, such as the filter, a large amount of cleaning liquid must be used for cleaning. In addition, since the flow resistance of the flow path in the stock liquid flow path of the filter is large, and the cleaning liquid that has passed through the filter component is supplied to the stock liquid flow path of the filter, the flow rate and pressure of the cleaning liquid flowing in the stock liquid flow path of the filter become smaller. Therefore, even if the cleaning liquid flows in the stock liquid flow path of the filter, it may not be possible to fully clean the stock liquid flow path of the filter.

[0020] The present invention is completed in view of such a situation, and its purpose is to provide a raw liquid processing device and an operating method of the raw liquid processing device, which can easily perform leakage inspection, and the air exhaust operation after the leakage inspection is also relatively easy, and the flow path can be effectively cleaned.

[0021] Solutions for solving the above technical problems

[0022] (Leakage Check)

[0023] The first invention is an operating method for a raw liquid processing device, wherein the raw liquid processing device comprises: a filter having a filtering component for filtering raw liquid; a concentrator supplied with filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid, and the operating method for the raw liquid processing device is characterized in that the filter comprises: a main body having an internal space isolated by a flow path for supplying the raw liquid and the filtering component; a filtrate discharge port connecting the internal space of the main body with the outside, and in a state where the internal space of the main body is airtightly isolated from the outside, pressurized gas is supplied to the internal space from the filtrate discharge port, thereby measuring the pressure of the gas in the internal space.

[0024] The operating method of the raw liquid processing device of the second invention is characterized in that, in the first invention, while the flow path for supplying the raw liquid is airtightly isolated from the outside, the pressure of the flow path for supplying the raw liquid and the pressure of the gas in the internal space of the filter are measured, and the two pressures are compared.

[0025] The operating method of the raw liquid processing device of the third invention is characterized in that, in the second invention, a liquid delivery section for generating a flow of liquid in the flow path is provided in the flow path connected to the flow path for supplying the raw liquid, and the liquid delivery section is operated while the pressurized gas is supplied from the filtrate discharge port to the internal space so that the liquid flows from the flow path for supplying the raw liquid to the direction of discharging the liquid.

[0026] The operating method of the raw liquid treatment device of the fourth invention is characterized in that, in the second or third invention, the pressure of the flow path in the flow path for supplying the raw liquid is maintained constant while the pressurized gas is supplied from the filtrate discharge port to the internal space.

[0027] The operating method of the raw liquid treatment device of the fifth invention is characterized in that, in the first, second, third or fourth invention, the filtering member of the filter is a hollow fiber membrane, and the internal space of the main body is a space for accommodating the hollow fiber membrane.

[0028] (Cleaning)

[0029] In the operating method of the raw liquid processing device of the 6th invention, the raw liquid processing device comprises: a filter, which has a filtering component for filtering the raw liquid; a concentrator, which is supplied with filtrate filtered by the filter and concentrates the filtrate to form a concentrated liquid. The operating method of the raw liquid processing device is characterized in that the filter comprises: a main body, which has an internal space isolated by a flow path for supplying the raw liquid and the filtering component; a raw liquid supply port and a cleaning liquid supply port, which are liquid-tightly separated from the internal space of the main body and are respectively connected to both ends of the flow path for supplying the raw liquid, so that the cleaning liquid flows between the raw liquid supply port and the cleaning liquid supply port.

[0030] The operating method of the raw liquid treatment device of the 7th invention is characterized in that, in the 6th invention, the filtering component of the filter is a plurality of hollow fiber membranes bundled together at one end and at the other end, the internal space of the main body is a space for accommodating the hollow fiber membranes internally, and is provided with a pair of collecting pipes, which are respectively connected to the two ends of the through-flow path of the plurality of hollow fiber membranes and are liquid-tightly isolated from the internal space of the main body, and have a larger cross-sectional area than the through-flow path, and each collecting pipe is provided with either the raw liquid supply port or the cleaning liquid supply port, and a negative pressure generating portion for generating negative pressure in the flow path connected to the raw liquid supply port is provided, so that the cleaning liquid flows between the raw liquid supply port and the cleaning liquid supply port and operates the negative pressure generating portion.

[0031] The operating method of the raw liquid treatment device of the eighth invention is characterized in that, in the sixth or seventh invention, the filter has a filtrate discharge port communicating with the internal space, and the negative pressure generating part is operated while the cleaning liquid flows through the filtrate discharge port.

[0032] The operating method of the raw liquid treatment device of the 9th invention is characterized in that, in the 8th invention, during the filtering and concentration operation, the raw liquid treatment device operates the liquid delivery section arranged in the flow path connected to the filtrate discharge port and discharges the filtrate from the filter, and during the cleaning operation, the cleaning liquid is pushed into the internal space of the filter through the filtrate discharge port.

[0033] (Dry liquid treatment device)

[0034] The stock liquid processing device of the tenth invention is a device for concentrating a stock liquid to form a concentrated liquid, and is characterized by comprising: a filter having a filtering member for filtering the stock liquid; a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form the concentrated liquid; a stock liquid supply unit for supplying the stock liquid to the filter; a liquid supply passage for connecting the stock liquid supply unit to a stock liquid supply port, the stock liquid supply port being connected to one end of a flow path for supplying the stock liquid of the filter; and a filtrate supply passage for connecting the filtrate of the filter to the filter. A liquid discharge port is connected to the filtrate supply port of the concentrator; a concentrated liquid flow path is connected to the concentrated liquid discharge port of the concentrator; a waste liquid flow path is connected to the waste liquid discharge port, and the waste liquid discharge port discharges the waste liquid separated from the concentrated liquid in the concentrator; a cleaning liquid supply flow path is connected to the filter cleaning liquid supply port, and the filter cleaning liquid supply port is connected to the other end of the flow path of the filter supplying the original liquid in the filter; a cleaning liquid recovery flow path is connected to the original liquid supply port of the filter; and a connecting flow path is connected to the filtrate supply flow path.

[0035] The raw liquid treatment device of the 11th invention is characterized in that, in the 10th invention, a liquid delivery section for carrying out transportation in each flow path is provided in the filtrate supply flow path, the concentrated liquid flow path, the cleaning liquid supply flow path and the connecting flow path, and the connecting flow path is connected between the liquid delivery section provided in the filtrate supply flow path and the filter.

[0036] A twelfth invention is the raw liquid treatment device according to the tenth invention, wherein the filtrate supply flow path, the concentrate flow path, and the cleaning liquid supply flow path are provided with a liquid feeding section for performing transportation in each flow path.

[0037] A raw liquid treatment device according to a 13th invention is characterized in that, in the 12th invention, the connection channel connects between a liquid feeding section provided in the filtrate supply channel and the concentrator.

[0038] The stock solution processing device of the 14th invention is characterized in that, in the 10th invention, the liquid supply flow path, the cleaning liquid recovery flow path, the concentrated liquid flow path, and the connecting flow path are provided with a liquid feeding section for performing transportation in each flow path.

[0039] A raw liquid treatment device according to a fifteenth invention is characterized in that, in any one of the tenth to fourteenth inventions, the filter member is a hollow fiber membrane having a through flow path formed therein so as to penetrate in the axial direction.

[0040] Effects of the Invention

[0041] (Leakage Check)

[0042] According to the first invention, since the leak check is performed without gas entering the flow path for supplying the raw liquid, the air exhaust operation after the leak check can be performed reliably and in a short time.

[0043] According to the second invention, since the leakage inspection is performed by comparing the pressures inside and outside the flow channel to which the raw liquid is supplied, the accuracy of the leakage inspection can be improved.

[0044] According to the third and fourth aspects of the present invention, the accuracy of leakage inspection can be improved.

[0045] According to the fifth invention, even if the filter member is a hollow fiber membrane, the air discharge operation after the leakage check can be performed reliably and in a short time.

[0046] (Cleaning)

[0047] According to the sixth invention, if the cleaning liquid is made to flow between a pair of ports, the cleaning liquid can be directly supplied to the flow path supplied with the stock liquid, thereby improving the cleaning effect of the flow path supplied with the stock liquid. Moreover, only the amount of cleaning liquid that can clean the flow path supplied with the stock liquid is needed, thereby reducing the amount of cleaning liquid used.

[0048] According to the seventh aspect of the present invention, it becomes easy to remove large solid components and the like accumulated in the header portion.

[0049] According to the eighth and ninth aspects of the present invention, the cleaning effect can be improved.

[0050] (Dry liquid treatment device)

[0051] According to the tenth invention, if gas and cleaning liquid are appropriately supplied to the flow paths arranged in the respective flow paths, leakage inspection and cleaning of the flow paths can be performed efficiently.

[0052] According to the eleventh invention, the supply of the stock solution to the filter can be performed by negative pressure. Furthermore, since the filter is cleaned by positive pressure, clogging of the flow path supplied with the stock solution can be effectively eliminated.

[0053] According to the twelfth and thirteenth inventions, the supply of the stock solution to the filter can be performed by negative pressure, and the flow path of the filter to which the stock solution is supplied can be cleaned efficiently.

[0054] According to the fourteenth invention, the inside of the flow path of the filter to which the raw liquid is supplied can be cleaned efficiently.

[0055] According to the fifteenth invention, even if the filter member is a hollow fiber membrane, leakage inspection and cleaning of the flow path can be performed efficiently. BRIEF DESCRIPTION OF THE DRAWINGS

[0056] Figure 1 It is a schematic explanatory diagram of the leakage inspection work of the raw liquid processing device 1 of this embodiment.

[0057] Figure 2 It is a schematic explanatory diagram of the preparatory cleaning work of the raw liquid processing apparatus 1 according to the present embodiment.

[0058] Figure 3 It is a schematic explanatory diagram of the filtration and concentration operation of the raw liquid treatment device 1 according to the present embodiment.

[0059] Figure 4 It is a schematic explanatory diagram of the re-concentration operation of the raw liquid treatment device 1 according to the present embodiment.

[0060] Figure 5 It is a schematic explanatory diagram of the filter 10 .

[0061] Figure 6 It is a schematic explanatory diagram of the preparatory cleaning work of the raw liquid processing apparatus 1B according to another embodiment.

[0062] Figure 7 It is a schematic explanatory diagram of the filtration and concentration operation of the raw liquid treatment apparatus 1B according to another embodiment.

[0063] Figure 8 This is a schematic explanatory diagram of the re-concentration operation of a raw liquid treatment apparatus 1B according to another embodiment.

[0064] Fig. 9 It is a schematic explanatory diagram of a raw liquid processing apparatus 1C according to another embodiment.

[0065] Fig.10 It is a schematic explanatory diagram of a leakage check of a raw liquid processing apparatus 1C according to another embodiment.

[0066] Fig.11 It is a schematic explanatory diagram of a leakage check of a raw liquid processing apparatus 1C according to another embodiment.

[0067] Fig.12 It is a schematic explanatory diagram of the preparatory cleaning work of the raw liquid processing apparatus 1C according to another embodiment.

[0068] Fig.13 It is a schematic explanatory diagram of the filtration and concentration operation of a raw liquid treatment apparatus 1C according to another embodiment.

[0069] Fig.14 It is a schematic explanatory diagram of a raw liquid processing apparatus 1D according to another embodiment.

[0070] Fig.15 It is a schematic explanatory diagram of a leakage check of a raw liquid processing apparatus 1C according to another embodiment.

[0071] Fig.16 This is a schematic explanatory diagram of another filter 10B. DETAILED DESCRIPTION

[0072] The stock solution treatment device of the present invention is a device for obtaining a treated solution, wherein the treated solution is a treated solution that can be administered to a patient by intravenous infusion or intraperitoneal administration after filtering and concentrating a stock solution such as pleural effusion or peritoneal effusion.

[0073] The stock liquid to be processed by the stock liquid processing device of the present invention is not particularly limited, and examples thereof include pleural effusion, plasma, blood, etc. Pleural effusion refers to pleural effusion or peritoneal effusion accumulated in the pleural cavity or abdominal cavity due to cancerous pleural peritonitis, liver cirrhosis, etc. The pleural effusion contains plasma components (proteins, hormones, sugars, lipids, electrolytes, vitamins, bilirubin, amino acids, etc.), hemoglobin, cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. that have seeped from blood vessels or internal organs. In the stock liquid processing device of the present invention, solid components such as cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. can be removed from the pleural effusion, thereby generating a concentrated solution containing water and useful components contained in the pleural effusion.

[0074] Examples of plasma include waste plasma from plasma exchange therapy, and examples of blood include blood recovered during surgery. That is, by purifying waste plasma, blood recovered during surgery, and the like using the stock solution treatment device of the present invention, reusable regenerated plasma can be produced. In addition, in the stock solution treatment device of the present invention, in the case of waste plasma from plasma exchange therapy, a plasma component separator can be used instead of a filter, and in the case of blood recovered during surgery, a plasma separator can be used instead of a filter.

[0075] In addition, the filter component of the filter of the raw liquid treatment device of the present invention is not particularly limited. In addition, there are also cases where the same membrane is used for the concentration of the filtrate in the concentrator. The filter component used for such filtration or concentration is a component that allows the plasma, water and the above-mentioned useful components contained in the pleural and abdominal effusion to pass through, and prevents cell components (i.e., solid components) such as cancer cells, macrophages, tissue cells, white blood cells, red blood cells, platelets, bacteria, etc. from passing through, and makes the gas impermeable, and its material, size, and shape are not particularly limited. For example, the shape of the filter component can use a hollow fiber membrane, a flat membrane, a laminated membrane, etc. In addition, the filter component can use a component formed by a material that performs the function of making the gas impermeable when wetted by a liquid. Of course, a component formed by a material that also performs the function of making the gas impermeable when not wetted by a liquid can also be used. In addition, in this specification, the gas that does not pass through the filter component refers to an inert gas such as nitrogen, air, oxygen, etc., which means a gas generally used for leakage inspection, etc.

[0076] As an example, a hollow fiber membrane used in a peritoneal fluid filter for CART, a plasma separator for plasma exchange, a plasma component separator for plasma exchange, etc. can be used in the filter and concentrator of the stock solution processing device of the present invention.

[0077] (Dry Liquid Processing Device of This Embodiment)

[0078] based on Figure 3 A raw liquid processing apparatus 1 according to the present embodiment will be described.

[0079] In the following, a case where the raw fluid to be treated is pleural and peritoneal effusion will be described as a representative example.

[0080] In addition, in the following description, the case where each flow path (liquid supply flow path, filtrate supply flow path, concentrated liquid flow path, waste liquid flow path, cleaning liquid supply flow path, cleaning liquid recovery flow path, connecting flow path) described in the claims is formed by a flexible or soft tube (liquid supply tube 2, filtrate supply tube 3, concentrated liquid tube 4, waste liquid tube 5, cleaning liquid supply tube 6, cleaning liquid recovery tube 7, connecting tube 9) is described. However, each flow path may be formed by a tube that is not flexible or soft (for example, a tube made of hard plastic or a steel tube, a vinyl chloride tube, etc.) or by an integrated circuit formed of a resin.

[0081] Furthermore, in the following description, the case where each flow path is formed by a flexible or soft tube is described, and therefore the description is based on the premise that a roller pump is used as the liquid delivery part of each flow path. However, the liquid delivery part only needs to be able to transport the liquid in each flow path, and it only needs to be appropriately selected to match the material of the tube constituting each flow path and the liquid flowing in the flow path. For example, an infusion pump or a diaphragm pump can be used. In addition, in the roller pump, since the clamping function (the function of closing the flow path so that the liquid cannot flow) is exerted when the operation is stopped, no device with a clamping function is provided in the flow path provided with the liquid delivery part in the following description. However, as the liquid delivery part, in the case of using a device that does not exert the clamping function even when the operation is stopped or using a device that does not have a clamping function, as long as a device with a clamping function (such as a clamp or a clamp, etc.) is separately provided in the flow path provided with the liquid delivery part, the device with a clamping function can exert the clamping function when the operation of the liquid delivery part is stopped.

[0082] (Schematic Structure of Stock Solution Treatment Device 1 of the Present Embodiment)

[0083] First, the schematic configuration of the raw liquid processing apparatus 1 according to the present embodiment will be described.

[0084] exist Figure 3 In the figure, reference numeral UB indicates a stock liquid bag for containing stock liquid, i.e., pleural and abdominal effusion extracted from the chest or abdomen. In addition, reference numeral CB indicates a concentrated liquid bag for containing concentrated liquid after filtering and concentrating the stock liquid. Furthermore, reference numeral DB indicates a waste liquid bag for containing waste liquid (i.e., water) separated from the concentrated liquid. Furthermore, reference numeral SB indicates a cleaning liquid bag containing cleaning liquid such as physiological saline or infusion (extracellular fluid), and reference numeral FB indicates a cleaning liquid recovery bag for recovering the cleaning liquid.

[0085] like Figure 3 As shown, in the raw liquid processing device 1 of this embodiment, the raw liquid bag UB is connected to the filter 10 via the liquid supply tube 2. The liquid supply tube 2 is a tube that supplies the raw liquid in the raw liquid bag UB to the filter 10. The liquid supply tube 2 is provided with a liquid supply tube liquid supply part 2p that transports the liquid in the liquid supply tube 2.

[0086] The filter 10 filters the raw liquid to generate a filtrate. The filter 10 is connected to the concentrator 20 via the filtrate supply pipe 3. The filtrate supply pipe 3 is a pipe for supplying the filtrate generated by the filter 10 to the concentrator 20. The filtrate supply pipe 3 is provided with a flow rate adjustment mechanism 3c such as a clamp or a clip for stopping or opening the flow of the liquid in the filtrate supply pipe 3.

[0087] One end of a connection pipe 9 is connected to the portion between the filter 10 and the flow rate adjustment mechanism 3c in the filtrate supply pipe 3. The connection pipe 9 is provided with a connection pipe liquid feeding portion 9p for feeding the liquid in the connection pipe 9.

[0088] In addition, a cleaning liquid bag SB is connected to the filter 10 via a cleaning liquid supply pipe 6. The cleaning liquid supply pipe 6 is a pipe for supplying the cleaning liquid from the cleaning liquid bag SB to the filter 10. The cleaning liquid supply pipe 6 is provided with a flow rate adjustment mechanism 6c such as a clamp or a clip for stopping or opening the flow of the liquid in the cleaning liquid supply pipe 6.

[0089] Furthermore, a cleaning liquid recovery bag FB for recovering the cleaning liquid used to clean the filter 10 is connected to the filter 10 via a cleaning liquid recovery pipe 7. The cleaning liquid recovery pipe 7 is provided with a cleaning liquid recovery pipe liquid feeding portion 7p for feeding the liquid in the cleaning liquid recovery pipe 7.

[0090] In addition, the cleaning liquid recovery pipe 7 may be connected to the filter 10 via the liquid supply pipe 2 or may be directly connected to the filter 10 .

[0091] The concentrator 20 generates a concentrated liquid obtained by concentrating the filtrate. The concentrator 20 is connected to a concentrated liquid bag CB via a concentrated liquid pipe 4. The concentrated liquid pipe 4 is a pipe for supplying the concentrated liquid concentrated by the concentrator 20 to the concentrated liquid bag CB. The concentrated liquid pipe 4 is provided with a concentrated liquid pipe liquid feeding section 4p for feeding the liquid in the concentrated liquid pipe 4.

[0092] Furthermore, a waste liquid bag DB is connected to the concentrator 20 via a waste liquid pipe 5. The waste liquid pipe 5 is a pipe for supplying the waste liquid (water) separated from the concentrated liquid by the concentrator 20 to the waste liquid bag DB.

[0093] Since the raw liquid processing device 1 of the present embodiment has the above-described configuration, when the raw liquid is supplied from the raw liquid bag UB to the filter 10 via the liquid supply pipe 2, the raw liquid can be filtered in the filter 10 to generate a filtrate. Then, when the generated filtrate is supplied to the concentrator 20 via the filtrate supply pipe 3, a concentrated liquid can be generated by the concentrator 20, and the concentrated liquid can be recovered to the concentrated liquid bag CB via the concentrated liquid supply pipe 4.

[0094] On the other hand, if the cleaning liquid is supplied from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 to the filter 10, the filter 10 can be cleaned with the cleaning liquid. In addition, if the cleaning liquid bag SB is connected to the concentrated liquid pipe 4 instead of the concentrated liquid bag CB, the concentrator 20 can be cleaned with the cleaning liquid (see Figure 2 ).

[0095] Hereinafter, the operation of the raw liquid processing apparatus 1 according to the present embodiment will be described.

[0096] (Prepare for cleaning)

[0097] like Figure 2 As shown, in the preparatory cleaning operation of the raw liquid treatment device 1 of this embodiment, the cleaning liquid bag SB is connected to the other end of the concentrated liquid pipe 4 instead of the concentrated liquid bag CB, and the cleaning liquid recovery bag FB is connected to the other end of the waste liquid pipe 5 instead of the waste liquid bag DB. In addition, the other end of the waste liquid pipe 5 may remain connected to the waste liquid bag DB, or may be simply arranged in a bucket or the like.

[0098] In addition, the cleaning liquid recovery bag FB is also connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB. In addition, the waste liquid bag DB can be connected to the other end of the liquid supply tube 2, or it can be simply arranged in a bucket or the like.

[0099] Furthermore, a cleaning liquid recovery bag FB is also connected to the other end of the connection tube 9. In addition, a waste liquid bag DB may be connected to the other end of the connection tube 9, or the waste liquid bag DB may be simply arranged in a bucket or the like.

[0100] Next, the washing liquid is caused to flow through the filtrate supply pipe 3 and the washing liquid supply pipe 6 by the flow rate adjustment mechanism 3 c and the flow rate adjustment mechanism 6 c.

[0101] In the above state, the concentrated liquid pipe liquid feeding part 4p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the concentrated liquid pipe 4 to the concentrator 20, and the connecting pipe liquid feeding part 9p is operated so that the cleaning liquid flows from the concentrator 20 (i.e., the filtrate supply pipe 3) to the cleaning liquid recovery bag FB connected to the connecting pipe 9. Thus, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrated liquid pipe 4 to the concentrator 20 through the concentrated liquid pipe 4. After passing through the concentrator 20, the supplied cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the connecting pipe 9 through the filtrate supply pipe 3 and the connecting pipe 9. In addition, a part of the cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the other end of the waste liquid pipe 5 through the waste liquid pipe 5.

[0102] Furthermore, the connecting tube liquid feeding section 9p is operated so that the cleaning liquid flows from the concentrator 20 to the cleaning liquid recovery bag FB connected to the connecting tube 9, and the liquid supply tube liquid feeding section 2p is operated so that the cleaning liquid flows from the filter 10 to the cleaning liquid recovery bag FB connected to the liquid supply tube 2. Thus, the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 through the cleaning liquid supply tube 6. After the supplied cleaning liquid passes through the filter 10, a part of it is recovered to the cleaning liquid recovery bag FB connected to the connecting tube 9 through the filtrate supply tube 3 and the connecting tube 9, and a part of it is recovered to the cleaning liquid recovery bag FB connected to the liquid supply tube 2 through the liquid supply tube 2. Furthermore, by operating the cleaning liquid recovery tube liquid feeding section 7p, a part of the cleaning liquid supplied to the filter 10 can also flow to the cleaning liquid recovery tube 7.

[0103] Thus, the cleaning liquid can flow through the filter 10, the concentrator 20, and all the tubes, and thus the entire raw liquid treatment device 1 of the present embodiment can be cleaned.

[0104] In addition, Figure 2 In the embodiment, the cleaning liquid is sucked out from the filter 10 by operating the liquid supply pipe liquid delivery part 2p and the cleaning liquid recovery pipe liquid delivery part 7p, and a flow of the cleaning liquid is generated in the filter 10, thereby cleaning the inside of the filter 10 with the cleaning liquid. However, the cleaning liquid may be pushed into the filter 10, and a flow of the cleaning liquid may be generated in the filter 10, thereby cleaning the inside of the filter 10.

[0105] For example, in Figure 2 In the embodiment, a cleaning liquid supply pipe delivery portion 6p is provided in the cleaning liquid supply pipe 6 to replace the flow rate adjustment mechanism 6c (see Figure 6 ), a flow rate adjustment mechanism 7c is provided in the cleaning liquid recovery pipe 7 instead of the cleaning liquid recovery pipe liquid delivery portion 7p. Then, the cleaning liquid recovery pipe 7 is opened by the flow rate adjustment mechanism 7c, and the cleaning liquid supply pipe liquid delivery portion 6p is operated in such a manner that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10 in the cleaning liquid supply pipe 6. As a result, the cleaning liquid can be pushed into the filter 10, and a flow of the cleaning liquid is generated in the filter 10, so that the inside of the filter 10 can be cleaned by the cleaning liquid. In this case, the liquid supply pipe liquid delivery portion 2p of the liquid supply pipe 2 can also be operated to suck the cleaning liquid out of the filter 10, so that the cleaning liquid flows in the liquid supply pipe 2. In addition, the liquid supply pipe liquid delivery portion 2p can also be not operated, and only the cleaning liquid can flow in the cleaning liquid recovery pipe 7.

[0106] (Filtration and concentration operation)

[0107] If the cleaning operation is completed, the filtration and concentration operation is performed.

[0108] like Figure 3As shown, in the filtering and concentrating operation of the raw liquid treatment device 1 of this embodiment, the concentrated liquid bag CB is connected to the concentrated liquid pipe 4 instead of the cleaning liquid bag SB in the state of preparing for the cleaning operation, and the waste liquid bag DB is connected to the waste liquid pipe 5 instead of the cleaning liquid recovery bag FB.

[0109] On the other hand, the liquid supply tube 2 is connected to a raw liquid bag UB instead of the cleaning liquid recovery bag FB.

[0110] Furthermore, the flow rate adjustment mechanism 3c maintains the state in which the liquid can flow in the filtrate supply pipe 3, while the flow rate adjustment mechanism 6c is closed so that the liquid cannot flow in the cleaning liquid supply pipe 6. In addition, the cleaning liquid recovery pipe liquid delivery part 7p and the connecting pipe liquid delivery part 9p are not operated and function as a clamp.

[0111] In the above state, the liquid supply tube delivery part 2p is operated in such a way that the raw liquid flows from the raw liquid bag UB connected to the liquid supply tube 2 to the filter 10, and the concentrated liquid tube delivery part 4p is operated in such a way that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB connected to the concentrated liquid tube 4.

[0112] Thus, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply pipe 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply pipe 3. Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrated liquid is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5.

[0113] (About filter cleaning)

[0114] In addition, during the filtering and concentrating operation of the raw liquid treatment device 1 of this embodiment, the filtering element of the filter 10 (in Figure 5 In the middle are multiple hollow fiber membranes 16 of the hollow fiber membrane bundle 15, Fig.16 Specifically, in Figure 3 In the embodiment, the flow rate adjustment mechanism 3c is used to block the liquid from flowing in the filtrate supply pipe 3. In addition, the operation of the liquid supply pipe 2p is stopped to function as a clamp. On the other hand, the liquid can flow in the cleaning liquid supply pipe 6 by the flow rate adjustment mechanism 6c.

[0115] In the above state, if the cleaning liquid recovery pipe liquid feeding section 7p is operated so as to cause the liquid to flow from the filter 10 to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery pipe 7, the cleaning liquid can flow in the flow path (in the direction opposite to the direction in which the raw liquid flows during filtration and concentration) of the filter 10 for raw liquid to flow. Figure 5The interior of the hollow fiber membrane 16 is shown in the middle. Fig.16 The liquid flows through the gaps in the filter membrane 17b, so the inside of the flow path of the filter 10 through which the raw liquid flows can be cleaned.

[0116] In addition to the above state, if the connecting tube liquid feeding part 9p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10, the cleaning liquid is also supplied from the cleaning liquid bag SB connected to the connecting tube 9 to the filter 10. Thus, since the cleaning liquid passes through the filter component in the direction opposite to the direction in which the filtrate passes through the filter component, clogging of the filter component can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply tube 6 and the cleaning liquid bag SB connected to the connecting tube 9, the operation of the cleaning liquid recovery tube liquid feeding part 7p and the connecting tube liquid feeding part 9p is adjusted so that the flow rate of the cleaning liquid flowing in the cleaning liquid recovery tube 7 through the cleaning liquid recovery tube liquid feeding part 7p becomes larger than the flow rate of the cleaning liquid flowing in the connecting tube 9 through the connecting tube liquid feeding part 9p.

[0117] Alternatively, the cleaning liquid recovery pipe liquid feeding portion 7p and the connecting pipe liquid feeding portion 9p may be operated with the flow rate adjustment mechanism 6c closed. In this case, the cleaning liquid is supplied to the filter 10 only from the cleaning liquid bag SB connected to the connecting pipe liquid feeding portion 9p. In this case, the cleaning liquid also passes through the filter component in the direction opposite to the direction in which the filtrate passes through the filter component, so that clogging of the filter component can be eliminated.

[0118] (Re-enrichment Operation)

[0119] When the concentrated liquid obtained by the filtration concentration operation is further concentrated, a re-concentration operation is performed.

[0120] like Figure 4 As shown, in the re-concentration operation of the raw liquid processing apparatus 1 of the present embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the other end of the connecting tube 9 is connected to the concentrated liquid bag CB.

[0121] In addition, the flow rate adjustment mechanism 3c is used to maintain the state in which the liquid can flow in the filtrate supply pipe 3, and on the other hand, the liquid supply pipe liquid delivery part 2p and the cleaning liquid recovery pipe liquid delivery part 7p are not operated and function as a clamp. In addition, the flow rate adjustment mechanism 6c is used to seal the cleaning liquid supply pipe 6 so that the liquid cannot flow. As a result, the filter 10 is in a state in which the liquid cannot flow.

[0122] In the above state, the connecting tube liquid feeding section 9p is operated so that the concentrated liquid flows from the concentrated liquid bag CB to the concentrator 20 through the connecting tube 9, and the concentrated liquid tube liquid feeding section 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB through the concentrated liquid tube 4.

[0123] Thus, the concentrated liquid is supplied to the concentrator 20 from the concentrated liquid bag CB connected to the connecting pipe 9 through the connecting pipe 9, and the re-concentrated liquid further concentrated by the concentrator 20 is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5. That is, a concentrated liquid (re-concentrated liquid) with a higher concentration ratio can be obtained.

[0124] (Detailed description of filter 10)

[0125] In the raw liquid treatment device 1 of this embodiment, each bag is connected to the filter 10 and the concentrator 20 as described above, but if the filter 10 has the following structure and each tube is connected to the filter 10 as follows, the filter 10 can be effectively cleaned and leak checked.

[0126] Hereinafter, the configuration of the filter 10 , the connection of each tube to the filter 10 , and the cleaning and leakage inspection of the filter 10 will be described.

[0127] (Filter 10)

[0128] The filter 10 is, for example, a peritoneal fluid filter for CART, a plasma separator for plasma exchange, a plasma component separator, etc. The filter 10 contains a filter element inside, and can filter the peritoneal fluid through the filter element and separate it into a filtrate and a separation liquid containing cells and the like.

[0129] The following is based on Figure 5 The structure of the filter 10 in the case where the filtering member is the hollow fiber membrane 16 will be described.

[0130] like Figure 5 As shown, the filter 10 includes a main body 11 and a hollow fiber membrane bundle 15 disposed in the main body 11 .

[0131] (Hollow fiber membrane bundle 15)

[0132] like Figure 5 As shown, the hollow fiber membrane bundle 15 is formed by bundling a plurality of hollow fiber membranes 16 .

[0133] The hollow fiber membrane 16 is a tubular member having a wall 16w with an annular cross section and an axial through-flow path 16h formed inside the wall 16w to penetrate the hollow fiber membrane 16. The wall 16w of the hollow fiber membrane 16 has the function of impermeability to solid components such as cells and gases but permeability to liquids.

[0134] The hollow fiber membrane bundle 15 is formed by bundling the plurality of hollow fiber membranes 16 at one end and at the other end so that the through-flow passage 16h of each hollow fiber membrane 16 penetrates between the one end and the other end of the hollow fiber membrane bundle 15.

[0135] The two ends of the plurality of hollow fiber membranes 16 do not necessarily need to be bundled together. In this case, the plurality of hollow fiber membranes 16 are arranged so that both ends of the through-flow passages 16h communicate with the pair of headers 13 and 14 of the body 11, respectively.

[0136] (Main body 11)

[0137] like Figure 5 As shown, the main body 11 is provided with a trunk 12, and the trunk 12 has a space that is airtightly and liquid-tightly isolated from the outside, that is, an internal space 12h. The internal space 12h of the trunk 12 is formed to be connected to the outside only through a port described later, and the above-mentioned hollow fiber membrane bundle 15 is accommodated inside. In a state where the above-mentioned hollow fiber membrane bundle 15 is accommodated inside, the internal space 12h is airtightly separated from the through-flow path 16h of the plurality of hollow fiber membranes 16, but the liquid can pass through the wall 16w. That is, the liquid in the internal space 12h can be supplied to the through-flow path 16h, and the liquid in the through-flow path 16h can be supplied to the internal space 12h.

[0138] In addition, the size and shape of the internal space 12h are not particularly limited. In the state where the hollow fiber membrane bundle 15 is accommodated, the liquid flowing into the internal space 12h through the port flows between the hollow fiber membrane bundle 15 and the inner surface of the trunk 12 (i.e., the inner surface of the internal space 12h) and between the plurality of hollow fiber membranes 16, as long as it has a size that can flow into the through-flow path 16h through the wall 16w of the hollow fiber membrane 16. In addition, the liquid flowing out of the through-flow path 16h to the internal space 12h through the wall 16w of the hollow fiber membrane 16 flows between the plurality of hollow fiber membranes 16 and between the hollow fiber membrane bundle 15 and the inner surface of the internal space 12h, as long as it has a size that can flow out from the port.

[0139] like Figure 5As shown, a pair of manifolds 13 and 14 are provided in the main body 11 in a manner of sandwiching the trunk 12, that is, sandwiching the internal space 12h. The pair of manifolds 13 and 14 are spaces that are airtightly and liquid-tightly isolated from the internal space 12h of the trunk 12 and the outside, and are formed to be connected to the outside only through the port described later. In addition, the ends of the above-mentioned hollow fiber membrane bundle 15 are respectively connected to the pair of manifolds 13 and 14. Specifically, the two ends of the hollow fiber membrane bundle 15 are respectively connected to the pair of manifolds 13 and 14, so that the openings at both ends of the through-flow path 16h of the multiple hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15 are connected to the pair of manifolds 13 and 14. Therefore, the pair of manifolds 13 and 14 are connected through the through-flow path 16h of the multiple hollow fiber membranes 16 constituting the hollow fiber membrane bundle 15.

[0140] (Each port 11a to 11c)

[0141] As described above, the main body 11 is provided with the internal space 12 h formed in the trunk 12 of the main body 11 and the ports 11 a to 11 c for communicating the pair of headers 13 and 14 with the outside.

[0142] like Figure 5 As shown, a raw liquid supply port 11a is provided at one end of the main body 11 to connect the manifold 13 to the outside. One end of the liquid supply tube 2 is connected to the raw liquid supply port 11a, and the other end of the liquid supply tube 2 is connected to the liquid discharge port of the raw liquid bag UB (see Figure 3 ).

[0143] In addition, the cleaning liquid recovery bag FB is connected to the raw liquid supply port 11a via the liquid supply pipe 2, or is directly connected to the raw liquid supply port 11a. Specifically, one end of the cleaning liquid recovery pipe 7 is connected to the liquid supply pipe 2 or the raw liquid supply port 11a, and the other end of the cleaning liquid recovery pipe 7 is connected to the cleaning liquid recovery bag FB (see Figure 3 ).

[0144] A filtrate discharge port 11c is provided on the side of the trunk portion 12 of the main body 11 so as to communicate the internal space 12h with the outside. One end of the filtrate supply pipe 3 is connected to the filtrate discharge port 11c, and the other end of the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20 (see Figure 3 ). In addition, Figure 5 Two filtrate discharge ports 11c are provided in the apparatus, or one filtrate discharge port 11c may be provided.

[0145] A cleaning liquid supply port 11b is provided at the other end of the main body 11 so that the manifold 14 communicates with the outside. One end of the cleaning liquid supply pipe 6 is connected to the cleaning liquid supply port 11b, and the other end of the cleaning liquid supply pipe 6 is connected to the cleaning liquid bag SB (see Figure 3 ).

[0146] (Function of filter 10)

[0147] The filter 10 has the above-described structure, and as described above, the stock liquid bag UB and the cleaning liquid bag SB are connected to the ports 11a to 11c of the main body 11 via the respective tubes. Therefore, when the liquid supply pipe liquid delivery portion 2p is operated to supply the stock liquid from the stock liquid bag UB to the header portion 13 of the main body 11 via the liquid supply pipe 2 and the stock liquid supply port 11a, the stock liquid is supplied to the through-flow path 16h of the hollow fiber membrane 16 of the hollow fiber membrane bundle 15, and the stock liquid is filtered through the hollow fiber membrane 16. That is, since the solid components contained in the stock liquid cannot pass through the hollow fiber membrane 16, they remain in the through-flow path 16h, and only the liquid component, that is, the filtrate, passes through the wall 16w of the hollow fiber membrane 16, so that the filtrate obtained by filtering the stock liquid can be obtained.

[0148] After the filtrate is discharged from the hollow fiber membrane 16 to the internal space 12h of the trunk 12 of the main body 11 , it is supplied from the internal space 12h to the concentrator 20 through the filtrate discharge port 11c , the filtrate supply pipe 3 , and the filtrate supply port 20a of the concentrator 20 .

[0149] On the other hand, if the cleaning liquid recovery pipe liquid delivery portion 7p (or the liquid supply pipe liquid delivery portion 2p) is operated to suck the liquid out of the filter 10, the filter 10 can be cleaned. That is, since the cleaning liquid can be supplied from the cleaning liquid bag SB to the manifold portion 14 of the main body 11 via the cleaning liquid supply pipe 6 and the cleaning liquid supply port 11b, the cleaning liquid can be supplied from the manifold portion 14 to the through-flow path 16h of the hollow fiber membrane 16 (see Figure 2 That is, since the cleaning liquid flows from the header 14 toward the header 13, the through-flow path 16h of the hollow fiber membrane 16, especially the inner surface of the through-flow path 16h (the inner surface of the wall 16w), can be cleaned by the cleaning liquid flowing along the inner surface of the through-flow path 16h. As a result, solid components and the like attached to the inner wall of the through-flow path 16h of the hollow fiber membrane 16 can be effectively washed away.

[0150] In particular, the hollow fiber membrane 16 can be cleaned efficiently by performing the following operation.

[0151] First, the filtrate supply pipe 3 and the connecting pipe 9 are closed by the flow rate adjustment mechanism 3c provided in the filtrate supply pipe 3 and the connecting pipe liquid delivery portion 9p provided in the connecting pipe 9. On the other hand, the cleaning liquid supply pipe 6 is opened by the flow rate adjustment mechanism 6c. In this state, the cleaning liquid recovery pipe liquid delivery portion 7p of the cleaning liquid recovery pipe 7 is operated.

[0152] Thus, negative pressure is generated in the cleaning liquid recovery pipe 7 at a portion that is upstream of the cleaning liquid recovery pipe liquid feeding portion 7p, that is, on the filter 10 side. When such negative pressure is generated, the cleaning liquid flows from the cleaning liquid bag SB into the cleaning liquid recovery pipe 7 through the cleaning liquid supply pipe 6, the cleaning liquid supply port 11b, the header 14, the through flow path 16h of the hollow fiber membrane 16, the header 13, and the stock liquid supply port 11a.

[0153] At this time, since the filtrate supply pipe 3 and the connecting pipe 9 are closed, the cleaning liquid does not flow from the hollow fiber membrane 16 to the internal space 12h, but flows only in the through-flow path 16h of the hollow fiber membrane 16. Thus, only the through-flow path 16h between the pair of headers 13 and 14 and the hollow fiber membrane 16 can be cleaned by the cleaning liquid, so the cleaning liquid used for cleaning the filter 10 can be reduced.

[0154] Furthermore, since the internal space 12h is not cleaned, even if the filter 10 is cleaned after filtering and concentrating, the filtrate remains in the internal space 12h. Thus, the filtrate in the internal space 12h can be prevented from being discharged together with the cleaning liquid, thereby preventing a decrease in the recovery rate of the filtrate.

[0155] When cleaning the filter 10 , both the liquid supply pipe liquid delivery portion 2 p of the liquid supply pipe 2 and the cleaning liquid recovery pipe liquid delivery portion 7 p of the cleaning liquid recovery pipe 7 may be operated.

[0156] In addition, when cleaning the filter 10, the liquid feeding pipe liquid feeding part 2p may be operated instead of the cleaning liquid recovery pipe liquid feeding part 7p. In this case, since the raw liquid in the through-flow path 16h of the hollow fiber membrane 16 can be recovered into the raw liquid bag UB together with the cleaning liquid, if the cleaning liquid containing the recovered raw liquid is supplied to the filter again, the reduction in the recovery rate of the filtrate can be prevented.

[0157] Furthermore, as described above, when both or one of the liquid supply pipe liquid supply section 2p and the cleaning liquid recovery pipe liquid supply section 7p are operated, negative pressure is also generated in the through-flow path 16h of the hollow fiber membrane 16. Thus, even if solid components clog the walls 16w of the hollow fiber membrane 16, the solid components can be sucked out, and thus the clogging of the walls 16w of the hollow fiber membrane 16 can be eliminated.

[0158] In addition, when the main purpose is to eliminate the clogging of the wall 16w of the hollow fiber membrane 16, the cleaning liquid bag SB may be connected to the connecting pipe 9 in advance, and the connecting pipe liquid feeding part 9p may be operated so that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. In this case, since the cleaning of the internal space 12h is substantially performed, although the amount of cleaning liquid used increases, it becomes easier to eliminate the clogging of the wall 16w of the hollow fiber membrane 16. That is, in addition to the above-mentioned suction effect caused by the negative pressure, there is also an effect of pushing the cleaning liquid by the connecting pipe liquid feeding part 9p, so it becomes easier to eliminate the clogging of the wall 16w of the hollow fiber membrane 16.

[0159] Furthermore, when the cleaning operation is performed as described above, it becomes easy to eliminate the clogging of the header section 13 to which the raw liquid is supplied.

[0160] In the manifold 13 to which the stock solution is supplied, the solid components contained in the stock solution are supplied to the liquid supply pipe 2 as they are. Therefore, when the solid components are large, the opening of the through-flow path 16h of the hollow fiber membrane 16 may be clogged with the solid components. However, as described above, if a negative pressure is generated in the cleaning liquid recovery pipe 7 at a position closer to the filter 10 than the cleaning liquid recovery pipe liquid delivery portion 7p, the solid components can be sucked out from the manifold 13 to the cleaning liquid recovery pipe 7 by the negative pressure, so that the blockage of the manifold 13 can be eliminated. In this case, the cleaning liquid bag SB can also be connected to the connecting pipe 9 in advance, and the connecting pipe liquid delivery portion 9p can be operated so that the cleaning liquid flows from the cleaning liquid bag SB toward the filter 10. As a result, in addition to the above-mentioned suction effect caused by the negative pressure, the cleaning liquid is pushed in by the connecting pipe liquid delivery portion 9p, so that the blockage of the manifold 13 becomes easier to eliminate. In addition, in the case of the above-mentioned configuration, the cleaning liquid recovery pipe liquid delivery portion 7p is equivalent to the negative pressure generating portion described in the claims.

[0161] (Leakage Check)

[0162] In addition, in the filter 10, if the multiple hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are damaged, when the raw liquid is supplied to the multiple hollow fiber membranes 16 of the hollow fiber membrane bundle 15, the raw liquid may not be filtered and leak into the internal space 12h. Similarly, in the case where the air tightness and liquid tightness between the internal space 12h and the pair of manifolds 13 and 14 cannot be maintained, the raw liquid may not be filtered and leak into the internal space 12h. Therefore, before processing the raw liquid, the leakage of the filter 10 must be confirmed (leakage check). In the case of the raw liquid processing device 1 of the present embodiment, the leakage check can be implemented by the method described below.

[0163] The following is an explanation of the leak inspection process.

[0164] In addition, when performing preparatory cleaning, a leak check operation is performed before preparatory cleaning. Figure 1 As shown in FIG. 1 , a case where the leakage inspection work is performed while the raw liquid processing apparatus 1 of the present embodiment is kept in the state immediately before being prepared for cleaning will be described.

[0165] In addition, a case where a branch pipe 9b connected to the connecting pipe 9 is provided in the connecting pipe 9, and a pressurized gas supply unit GS for supplying pressurized gas during the leakage inspection operation is provided in the branch pipe 9b of the connecting pipe 9. In addition, in this case, a flow regulating mechanism 9c for closing or opening the branch pipe 9b is provided in the branch pipe 9b.

[0166] (First method)

[0167] First, if Figure 1 As shown, a pressure gauge P1 for measuring the pressure in the filtrate supply pipe 3 is provided in the filtrate supply pipe 3. The pressure gauge P1 may be temporarily provided during a leak check operation, or may be always provided during a filtration and concentration operation, etc. When always provided, a pressure gauge capable of measuring both air pressure and hydraulic pressure is used as the pressure gauge P1.

[0168] Next, the filtrate supply pipe 3 is closed by the flow control mechanism 3c, and the operation of the connecting pipe liquid supply part 9p of the connecting pipe 9 is stopped, and the branch pipe 9b is closed by the flow control mechanism 9c. Thus, the internal space 12h of the main body 11 is hermetically isolated from the outside.

[0169] On the other hand, the liquid supply pipe liquid delivery portion 2p connected to the liquid supply pipe 2 and the cleaning liquid recovery pipe liquid delivery portion 7p connected to the cleaning liquid recovery pipe 7 are not operated, and the cleaning liquid supply pipe 6 is also closed by the flow rate adjustment mechanism 6c. As a result, the through flow path 16h of the pair of headers 13 and 14 and the hollow fiber membrane 16 of the hollow fiber membrane bundle 15 is also in an airtight state isolated from the outside.

[0170] After the above state is reached, if the flow rate adjustment mechanism 9c is opened and the pressurized gas is supplied from the pressurized gas supply unit GS to the branch pipe 9b, the pressurized gas is supplied to the internal space 12h of the trunk 12 of the main body 11, and the pressure in the internal space 12h (in other words, the pressure in the connecting pipe 9 and the branch pipe 9b) rises. Then, if the pressure in the internal space 12h measured by the pressure gauge P1 reaches a certain pressure or more, the pressurized gas supplied by the pressurized gas supply unit GS is stopped, and the branch pipe 9b is closed by the flow rate adjustment mechanism 9c.

[0171] Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are damaged, or the airtightness or liquidtightness between the internal space 12h and the pair of headers 13 and 14 is poor, the pressurized gas leaks from the portion (the poor portion) into the through-flow path 16h of the hollow fiber membrane 16 or into the pair of headers 13 and 14. As a result, the pressure in the internal space 12h decreases, and therefore, by checking the change in the gas pressure measured by the pressure gauge P1, leakage of the filter 10 can be confirmed.

[0172] Furthermore, when the leak check is performed by the above method, if there is no defective part, the gas will not enter the through-flow path 16h of the hollow fiber membrane 16. That is, since the leak check can be performed without the gas entering the through-flow path 16h of the hollow fiber membrane 16, the air exhaust operation after the leak check can be performed reliably and in a short time.

[0173] In addition, when the leakage inspection is implemented by the above method, it is preferred to reduce the air pressure of the through-flow path 16h of the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 and the portion (a pair of manifolds 13, 14 and the liquid supply pipe 2, the cleaning liquid supply pipe 6, and the cleaning liquid recovery pipe 7) connected to the through-flow path 16h in advance. As a result, when the pressurized gas is supplied from the pressurized gas supply part GS through the branch pipe 9b, it becomes easy to generate leakage from the defective part. In this case, when the branch pipe 9b is closed by the flow adjustment mechanism 9c, the change of air pressure becomes faster in the presence of a defective part, so the leakage inspection operation time can be shortened. In addition, if the air pressure of the through-flow path 16h and the like becomes low, even if the pressurized gas is supplied, the time for the pressure in the internal space 12h to reach a certain pressure or above becomes longer due to the leakage from the defective part. Thus, by confirming this time, it is also possible to confirm whether there is a defective part.

[0174] In the above example, not only the internal space 12h but also the pair of headers 13, 14 and the through-flow passage 16h of the hollow fiber membrane 16 of the hollow fiber membrane bundle 15 are hermetically isolated from the outside. However, the pair of headers 13, 14 and the through-flow passage 16h of the hollow fiber membrane 16 of the hollow fiber membrane bundle 15 may be in communication with the outside.

[0175] (Second method)

[0176] In the first method described above, the pressure in the internal space 12h is measured and a leak check is performed. Alternatively, a pressure gauge P2 may be provided in any one of the liquid supply pipe 2, the cleaning liquid supply pipe 6, and the cleaning liquid recovery pipe 7 to perform a leak check. That is, leaks may be confirmed not only by the pressure gauge P1 but also by the pressure gauge P2. For example, Figure 1As shown, a pressure gauge P2 is provided on the liquid supply pipe 2. In this case, if there is a defective portion that allows pressurized gas to flow into the through-flow path 16h, the pressure of the pressure gauge P1 decreases, and the pressure of the pressure gauge P2 increases. Therefore, leakage can also be confirmed by the pressure of the pressure gauge P2.

[0177] In addition, when the pressurized air is supplied from the pressurized gas supply unit GS to the circuit, it is desirable to operate in a manner of sucking air from the filter 10 through the cleaning liquid recovery pipe liquid delivery unit 7p and the liquid supply pipe liquid delivery unit 2p so that the pressure measured by the pressure gauge P2 is constant. This is because when there is liquid in the internal space 12h, the pressure measured by the pressure gauge P2 may become higher than the pressure measured by the pressure gauge P1 by discharging the liquid to the through-flow path 16h of the hollow fiber membrane 16. Therefore, in order to reliably detect the leakage from the internal space 12h to the hollow fiber membrane 16 and the like and realize stable leakage inspection, it is desirable to operate in a manner of sucking air from the filter 10 through the cleaning liquid recovery pipe liquid delivery unit 7p and the liquid supply pipe liquid delivery unit 2p so that the pressure measured by the pressure gauge P2 is constant while the pressurized air is supplied from the pressurized gas supply unit GS to the circuit. For example, it is desirable to operate the cleaning liquid recovery pipe liquid feeding portion 7p and the liquid supply pipe liquid feeding portion 2p so that the pressure measured by the pressure gauge P2 becomes lower than the pressure measured by the pressure gauge P1.

[0178] In particular, by utilizing the pressure difference between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2, the pressure inside and outside the wall 16w of the hollow fiber membrane 16 can be compared to perform a leakage inspection, thereby improving the accuracy of the leakage inspection.

[0179] Furthermore, when the leakage inspection is performed by the second method, the pressure gauges P1 and P2 may be temporarily installed during the leakage inspection operation, or may be always installed during the filtration and concentration operation, etc. When always installed, pressure gauges capable of measuring both air pressure and hydraulic pressure are used as the pressure gauges P1 and P2.

[0180] In addition, when the leak check is performed using the pressure of the pressure gauge P2, during the period when the pressurized gas from the pressurized gas supply unit GS is not supplied, the through-flow path 16h of the hollow fiber membrane 16 and the like are made airtightly isolated from the outside by the cleaning liquid recovery pipe liquid supply unit 7p, the liquid supply pipe liquid supply unit 2p, and the flow rate adjustment mechanism 6c. In addition, it is necessary to stop the operation of the filtrate supply pipe liquid supply unit 3p provided in the filtrate supply pipe 3, the connecting pipe liquid supply unit 9p provided in the connecting pipe 9, and the flow rate adjustment mechanism 9c in advance. In addition, as described above, during the period when the gas is supplied from the pressurized gas supply unit GS, in order to keep the pressure measured by the pressure gauge P2 constant, it is desirable to drive the cleaning liquid recovery pipe liquid supply unit 7p and the liquid supply pipe liquid supply unit 2p.

[0181] (Detailed Description of Concentrator 20)

[0182] In the raw liquid treatment apparatus 1 of the present embodiment, it is desirable that each tube is connected to the concentrator 20 as follows. Hereinafter, the configuration of the concentrator 20 and the connection of each tube to the concentrator 20 will be described.

[0183] The concentrator 20 is supplied with filtrate from the filter 10 and concentrates the filtrate. The concentrator 20 has substantially the same structure as the filter 10, and has the function of separating water from the filtrate to form a concentrated liquid. That is, the concentrator 20 has a structure in which a water separation component is housed instead of the separation component of the filter 10, and the water separation component has the function of separating water from the filtrate. For example, a peritoneal effusion concentrator for CART, a dialysis filter for dialysis, a membrane type plasma component fractionator for double filtration plasma exchange therapy, etc. are used for the concentrator 20.

[0184] Specifically, the concentrator 20 includes a filtrate supply port 20a connected to the filtrate discharge port 11c of the filter 10 via the filtrate supply pipe 3. That is, the filtrate, which is the liquid to be concentrated, is supplied to the concentrator 20 from the filtrate supply port 20a.

[0185] The concentrator 20 also includes a waste liquid outlet 20c for discharging the liquid (separated liquid) separated from the filtrate, that is, water, etc. The waste liquid outlet 20c is connected to the waste liquid bag DB via the waste liquid pipe 5. The concentrator 20 also includes a concentrated liquid outlet 20b for discharging the concentrated liquid. The concentrated liquid outlet 20b is connected to the concentrated liquid bag CB via the concentrated liquid pipe 4.

[0186] Furthermore, the concentrator 20 includes a water separation member. The water separation member has a function of allowing water to pass through but preventing useful components such as useful proteins contained in plasma from passing through.

[0187] Therefore, when the filtrate is supplied to the concentrator 20 from the filtrate supply port 20a, water is separated from the filtrate by the water separation member, and the separated water is discharged from the waste liquid discharge port 20c and supplied to the waste liquid bag DB through the waste liquid pipe 5. On the other hand, the concentrated liquid from which part of the water is removed is discharged from the concentrated liquid discharge port 20b, and the discharged concentrated liquid is supplied to the concentrated liquid bag CB through the concentrated liquid pipe 4 (see Figure 3 ).

[0188] (Dry Liquid Treatment Device 1B of Another Embodiment)

[0189] In the raw liquid treatment apparatus 1 of the present embodiment described above, the raw liquid is supplied to the filter 10 by pushing it during filtration and concentration. However, the raw liquid may be supplied to the filter 10 by sucking it out from the filter 10 .

[0190] That is, Figure 7 As shown, in the raw liquid treatment device 1B of this embodiment, the raw liquid is supplied to the filter 10 in a manner of sucking the raw liquid out from the filter 10. That is, the filtrate supply pipe 3 is provided with a filtrate supply pipe liquid delivery portion 3p instead of the flow rate adjustment mechanism 3c, and the liquid supply pipe 2 is provided with a flow rate adjustment mechanism 2c instead of the liquid supply pipe liquid delivery portion 2p.

[0191] In the raw liquid treatment device 1B, the filtrate supply pipe liquid delivery part 3p is operated during filtration and concentration to allow the liquid (filtrate) to flow from the filter 10 to the concentrator 20. If the filtrate supply pipe liquid delivery part 3p is operated, the filter 10 side that is closer to the upstream side than the filtrate supply pipe liquid delivery part 3p in the filtrate supply pipe 3 becomes negative pressure, and the inside of the filter 10 (for example, the internal space 12h of the trunk 12 of the main body 11) also becomes negative pressure. Therefore, if the liquid supply pipe 2 is made to be able to transport liquid by the flow adjustment mechanism 2c, the raw liquid in the raw liquid bag UB can be sucked into the filter 10 through the liquid supply pipe 2, and the sucked raw liquid can be sucked into the filtrate supply pipe 3.

[0192] In this raw liquid processing apparatus 1B, by appropriately changing the bags connected to the respective tubes and adjusting the operation of the flow rate adjustment mechanism and the liquid delivery unit provided in the respective tubes, it is possible to perform the preparatory cleaning operation, the filtration concentration operation, and the re-concentration operation.

[0193] (Prepare for cleaning)

[0194] like Figure 6 As shown, the cleaning liquid bag SB is connected to the other end of the concentrate bag 4 instead of the concentrate bag CB, and the cleaning liquid recovery bag FB is connected to the other end of the waste liquid pipe 5 instead of the waste liquid bag DB. In addition, the other end of the waste liquid pipe 5 can remain connected to the waste liquid bag DB, or it can be simply arranged in a bucket or the like.

[0195] In addition, the cleaning liquid recovery bag FB is also connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB. In addition, the other end of the liquid supply tube 2 can be connected to a waste liquid bag DB, or it can be simply arranged in a bucket or the like.

[0196] Furthermore, a cleaning liquid recovery bag FB is also connected to the other end of the connection tube 9. In addition, a waste liquid bag DB may be connected to the other end of the connection tube 9, or the waste liquid bag DB may be simply arranged in a bucket or the like.

[0197] Furthermore, the cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply pipe 6 instead of the cleaning liquid bag SB, and the cleaning liquid bag SB is connected to the other end of the cleaning liquid recovery pipe 7 instead of the cleaning liquid recovery bag FB. In addition, the other end of the cleaning liquid supply pipe 6 and the other end of the cleaning liquid recovery pipe 7 may also be connected to a waste liquid bag DB, or they may be simply arranged in a bucket or the like.

[0198] Next, the cleaning liquid is caused to flow through the liquid supply pipe 2 and the connecting pipe 9 by the flow rate adjustment mechanism 2 c and the flow rate adjustment mechanism 2 c.

[0199] In the above state, the concentrate pipe liquid delivery part 4p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the concentrate pipe 4 to the concentrator 20, and the filtrate supply pipe liquid delivery part 3p is operated so that the cleaning liquid flows from the concentrator 20 (i.e., the filtrate supply pipe 3) to the cleaning liquid recovery bag FB connected to the connection pipe 9. Thus, the cleaning liquid is supplied from the cleaning liquid bag SB connected to the concentrate pipe 4 to the concentrator 20 through the concentrate pipe 4. After passing through the concentrator 20, the supplied cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the connection pipe 9 through the filtrate supply pipe 3 and the connection pipe 9. In addition, a part of the cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the other end of the waste liquid pipe 5 through the waste liquid pipe 5.

[0200] In addition, the cleaning liquid recovery pipe liquid feeding section 7p is operated in such a manner that the cleaning liquid flows from the cleaning liquid bag SB connected to the cleaning liquid recovery pipe 7 to the filter 10. Thus, a portion of the cleaning liquid is supplied to the filter 10 from the cleaning liquid bag SB connected to the cleaning liquid recovery pipe 7 through the cleaning liquid recovery pipe 7. After passing through the filter 10, the cleaning liquid supplied to the filter 10 is recovered to the cleaning liquid recovery bag FB connected to the connection pipe 9 through the filtrate supply pipe 3 and the connection pipe 9. In addition, by operating the cleaning liquid supply pipe liquid feeding section 6p, a portion of the cleaning liquid supplied to the filter 10 can also flow to the cleaning liquid supply pipe 6. Furthermore, a portion of the cleaning liquid is recovered from the cleaning liquid recovery pipe 7 through the liquid supply pipe 2 to the cleaning liquid recovery bag FB connected to the liquid supply pipe 2.

[0201] Thus, the cleaning liquid can flow through the filter 10, the concentrator 20, and all the tubes, and thus the entire raw liquid treatment apparatus 1B of the present embodiment can be cleaned.

[0202] (Filtration and concentration operation)

[0203] When the cleaning operation is completed, the filtration and concentration operation is performed.

[0204] like Figure 7As shown, in the filtration and concentration operation of the raw liquid treatment device 1B of this embodiment, from the state of preparing for the cleaning operation, the concentrated liquid bag CB is connected to the other end of the concentrated liquid tube 4 instead of the cleaning liquid bag SB, and the waste liquid bag DB is connected to the other end of the waste liquid tube 5 instead of the cleaning liquid recovery bag FB.

[0205] On the other hand, the original liquid bag UB is connected to the other end of the liquid supply tube 2 instead of the cleaning liquid recovery bag FB.

[0206] In addition, the flow rate adjustment mechanism 2c maintains the state in which the liquid can flow in the liquid supply tube 2, and on the other hand, the flow rate adjustment mechanism 9c is closed so that the liquid cannot flow in the connecting tube 9. In addition, the cleaning liquid recovery tube liquid delivery part 7p and the cleaning liquid supply tube liquid delivery part 6p are not operated and function as a clamp.

[0207] In the above state, the filtrate supply pipe liquid feeding part 3p is operated so that the filtrate flows from the filter 10 to the concentrator 20, and the concentrated liquid pipe liquid feeding part 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB.

[0208] Thus, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply pipe 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply pipe 3. Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrated liquid is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5.

[0209] (About filter cleaning)

[0210] During the filtration and concentration operation of the raw liquid treatment device 1B of this embodiment, the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10 may be cleaned. Figure 7 In the process, the flow rate adjustment mechanism 2c is used to close the liquid supply pipe 2 so that the liquid cannot flow. In addition, the filtrate supply pipe liquid delivery part 3p and the concentrate pipe liquid delivery part 4p are stopped to function as a clamp. In addition, when the filter is cleaned in the middle of the concentration and filtration operation, after the preparatory cleaning operation is completed, the cleaning liquid bag SB is connected to the other end of the cleaning liquid supply pipe 6 in advance instead of the cleaning liquid recovery bag FB, and the cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid recovery pipe 7 in advance instead of the cleaning liquid bag SB.

[0211] In the above state, the cleaning liquid supply pipe liquid delivery part 6p is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 to the filter 10, and the cleaning liquid recovery pipe liquid delivery part 7p is operated so that the cleaning liquid flows from the filter 10 to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery pipe 7. Thus, the cleaning liquid can flow inside the hollow fiber membrane 16 in the direction opposite to the direction in which the raw liquid flows during filtration and concentration, so that the inside of the hollow fiber membrane 16 can be cleaned by the cleaning liquid.

[0212] Furthermore, after the preparatory cleaning operation is completed, a cleaning liquid bag SB is connected to the other end of the connection pipe 9 in advance instead of the cleaning liquid recovery bag FB. Thus, if the liquid is caused to flow in the connection pipe 9 by the flow adjustment mechanism 9c, in addition to the above-mentioned state, the cleaning liquid can be supplied to the filter 10 from the cleaning liquid bag SB connected to the connection pipe 9. Thus, since the cleaning liquid supplied through the connection pipe 9 passes through the hollow fiber membrane 16 in the direction opposite to the direction in which the filtrate passes through the hollow fiber membrane 16, the clogging of the hollow fiber membrane 16 can be eliminated. In this case, since the cleaning liquid is supplied to the filter 10 from both the cleaning liquid bag SB connected to the cleaning liquid supply pipe 6 and the cleaning liquid bag SB connected to the connection pipe 9, the cleaning liquid recovery pipe liquid feeding portion 7p and the cleaning liquid supply pipe liquid feeding portion 6p are adjusted so that the flow rate of the cleaning liquid flowing in the cleaning liquid recovery pipe 7 through the cleaning liquid recovery pipe liquid feeding portion 7p becomes larger than the flow rate of the cleaning liquid flowing in the cleaning liquid supply pipe 6 through the cleaning liquid supply pipe liquid feeding portion 6p.

[0213] In addition, when the liquid is caused to flow in the connection pipe 9 by the flow rate adjustment mechanism 9c, the cleaning liquid recovery pipe liquid feeding portion 7p may be operated while the operation of the cleaning liquid supply pipe liquid feeding portion 6p is stopped. In this case, the cleaning liquid is supplied to the filter 10 only from the cleaning liquid bag SB connected to the connection pipe 9. In this case, the cleaning liquid also passes through the hollow fiber membrane 16 in the direction opposite to the direction in which the filtrate passes through the hollow fiber membrane 16, so that clogging of the hollow fiber membrane 16 can be eliminated.

[0214] (Re-enrichment Operation)

[0215] When the concentrated liquid obtained by the filtration concentration operation is further concentrated, a re-concentration operation is performed.

[0216] like Figure 8 As shown, in the re-concentration operation of the raw liquid processing apparatus 1B of the present embodiment, the other end of the connecting tube 9 is removed from the cleaning liquid bag SB, and the concentrated liquid bag CB is connected to the other end of the connecting tube 9 .

[0217] In addition, the flow rate adjustment mechanism 9c is used to maintain the state in which the liquid can flow in the connecting tube 9, and on the other hand, the cleaning liquid supply pipe liquid delivery part 6p and the cleaning liquid recovery pipe liquid delivery part 7p are not operated and function as a clamp. In addition, the flow rate adjustment mechanism 2c is used to seal the liquid so that the liquid cannot flow in the liquid supply pipe 2. As a result, the liquid is prevented from flowing in the filter 10.

[0218] In the above state, the filtrate supply pipe liquid delivery portion 3p is operated so that the concentrated liquid flows from the concentrated liquid bag CB to the concentrator 20 through the connecting pipe 9, and the concentrated liquid pipe liquid delivery portion 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB through the concentrated liquid pipe 4.

[0219] Thus, the concentrated liquid is supplied to the concentrator 20 from the concentrated liquid bag CB connected to the connecting tube 9 through the connecting tube 9, and the re-concentrated liquid further concentrated by the concentrator 20 is recovered to the concentrated liquid bag CB through the concentrated liquid tube 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid tube 5. That is, a concentrated liquid (re-concentrated liquid) with a higher concentration ratio can be obtained.

[0220] (Original Liquid Processing Device 1C of Other Embodiments)

[0221] In the above-mentioned raw liquid treatment device 1B of the present embodiment, when cleaning the filter 10, the cleaning liquid recovery pipe liquid feeding section 7p is operated and the cleaning liquid is supplied from the cleaning liquid bag SB connected to the connecting pipe 9, thereby eliminating the clogging of the hollow fiber membrane 16. That is, the negative pressure method is adopted to make the cleaning liquid flow from the outside of the hollow fiber membrane 16 to the inside of the hollow fiber membrane 16, thereby eliminating the clogging of the hollow fiber membrane 16.

[0222] On the other hand, Fig. 9 As shown, a raw liquid processing apparatus 1C according to another embodiment (hereinafter sometimes simply referred to as raw liquid processing apparatus 1C) is different from the raw liquid processing apparatus 1B in the following points.

[0223] In the raw liquid treatment device 1C, a flow rate adjustment mechanism 7c is provided in the cleaning liquid recovery pipe 7 instead of the cleaning liquid recovery pipe liquid delivery portion 7p, and a connecting pipe liquid delivery portion 9p is provided in the connecting pipe 9. In addition, a waste liquid bag DB is connected to the other end of the cleaning liquid supply pipe 6 instead of the cleaning liquid bag SB. Furthermore, the cleaning liquid is pushed from the outside of the hollow fiber membrane 16 into the inside of the hollow fiber membrane 16 (positive pressure) through the connecting pipe liquid delivery portion 9p, thereby eliminating the blockage of the hollow fiber membrane 16.

[0224] In the stock solution treatment apparatus 1C, the cleaning solution supply pipe liquid feeding portion 6 p of the cleaning solution supply pipe 6 is operated to flow the stock solution from the stock solution bag UB into the hollow fiber membrane 16 , thereby cleaning the inside of the hollow fiber membrane 16 with the stock solution.

[0225] Furthermore, in the raw liquid treatment device 1C, one end of a recirculation pipe 8 is connected between the connection portion of the filtrate supply pipe 3 and the connection pipe 9 and the filtrate supply pipe liquid delivery portion 3p. The recirculation pipe 8 is provided with a flow rate adjustment mechanism 8c.

[0226] Furthermore, a pressure gauge P1 for measuring the pressure of the internal space 12 h of the main body 11 is provided at the filtrate discharge port 11 c of the filter 10 to which the filtrate supply pipe 3 is not connected.

[0227] Furthermore, a pressure gauge P2 for measuring the pressure in the through-flow path 16 h of the hollow fiber membrane 16 is provided between the cleaning liquid supply pipe liquid feeding portion 6 p of the cleaning liquid supply pipe 6 and the filter 10 .

[0228] The pressure gauges P1 and P2 may be temporarily installed during a leak inspection operation or may be always installed during a filtration and concentration operation, etc. When always installed, pressure gauges capable of measuring both air pressure and hydraulic pressure are used as the pressure gauges P1 and P2.

[0229] Next, the processing operation of the raw liquid processing apparatus 1C having the above-mentioned structure will be described.

[0230] (Leakage Check)

[0231] A method of performing a leakage inspection in the raw liquid processing apparatus 1C will be described.

[0232] In addition, during the leak inspection, Fig. 9 The state is the state in which the filter cleaning operation can be performed. Change the following points (refer to Fig.10 ).

[0233] First, a pressurized gas supply unit GS is provided between the cleaning liquid supply pipe liquid delivery unit 6p and the filter 10 (near the pressure gauge P2). The method of providing the pressurized gas supply unit GS in the cleaning liquid supply pipe liquid delivery unit 6p is not particularly limited. For example, a branch flow path equipped with a clamp or the like may be provided in advance in the cleaning liquid supply pipe liquid delivery unit 6p, and the pressurized gas supply unit GS may be provided in the branch flow path.

[0234] First, in each tube, a bag is connected to the end portion on the side not connected to the filter 10 as described below.

[0235] A cleaning liquid bag SB is connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB.

[0236] A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply pipe 6 instead of the waste liquid bag DB. In addition, the bag connected to the other end of the cleaning liquid supply pipe 6 may still be the waste liquid bag DB, or may simply be arranged in a bucket or the like.

[0237] The bag connected to the other end of the cleaning liquid recovery pipe 7 may remain the cleaning liquid recovery bag FB, or may be changed to a waste liquid bag DB, or simply arranged in a bucket or the like.

[0238] As described above, when the bag is connected to each tube, all flow rate adjustment mechanisms provided in the tube are closed, and the operation of all the tube liquid delivery parts is stopped. Thus, all the tubes are in a closed state.

[0239] Next, in the filtrate supply pipe 3, the end portion connected to the filtrate supply port 20a of the concentrator 20 is removed from the filtrate supply port 20a, and connected to the cleaning liquid recovery bag FB.

[0240] Furthermore, the other end of the recycling pipe 8 is removed from the concentrated liquid bag CB and connected to the cleaning liquid recovery bag FB as an open end.

[0241] In addition, the other end of the filtrate supply pipe 3 and the other end of the recycling pipe 8 may be connected to the waste liquid bag DB, or may be simply arranged in a bucket or the like.

[0242] In addition, the tube connected to the concentrator 20 may be as follows.

[0243] The other end of the concentrated liquid pipe 4 is connected to a cleaning liquid recovery bag FB instead of the concentrated liquid bag CB. The other end of the waste liquid pipe 5 is connected to a cleaning liquid recovery bag FB instead of the waste liquid bag DB. In addition, the other end of the concentrated liquid pipe 4 can be connected to a waste liquid bag DB, or it can be simply placed in a bucket or the like. In addition, the other end of the waste liquid pipe 5 can be connected to a waste liquid bag DB, or it can be simply placed in a bucket or the like.

[0244] <Liquid discharge>

[0245] If the above preparations are completed (refer to Fig.10 ), when there is a possibility that liquid exists in the filter 10 (in the through flow path 16h of the hollow fiber membrane 16, in the pair of headers 13, 14, and in the internal space 12h), the liquid in the filter 10 is discharged as follows.

[0246] The flow rate adjustment mechanism 7c provided in the cleaning liquid recovery pipe 7 is opened, and air is supplied from the pressurized gas supply unit GS to pressurize the circuit (i.e., the filter 10 and each pipe). As a result, the liquid existing in the hollow fiber membrane 16 of the filter 10 and the pair of manifolds 13 and 14 can be discharged through the raw liquid supply port 11a, and the discharged liquid can be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery pipe 7. When the liquid in the filter 10 is discharged, the flow rate adjustment mechanism 7c is closed.

[0247] In addition, in the case of the above method, the liquid in the internal space 12h of the filter 10 cannot be recovered. Therefore, when the liquid in the internal space 12h of the filter 10 is discharged, the following operation is performed before the above operation, so that the liquid in the internal space 12h can be recovered.

[0248] For example, in a state where the filtrate discharge port 11c connected to the pressure gauge P1 is opened to the atmosphere, the cleaning liquid supply pipe liquid delivery portion 6p provided in the cleaning liquid supply pipe 6 is operated to suck the liquid from the filter 10. Thus, the liquid in the internal space 12h of the filter 10 is also sucked by the suction force, and can be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6. In this case, the filtrate supply pipe liquid delivery portion 3p provided in the filtrate supply pipe 3 can also be operated together with the cleaning liquid supply pipe 6 or before the cleaning liquid supply pipe 6 is operated to suck the liquid from the filter 10. Thus, the liquid in the internal space 12h of the filter 10 can also be recovered to the cleaning liquid recovery bag FB connected to the filtrate supply pipe 3.

[0249] In addition, when the other end of the recycling pipe 8 is not connected to the cleaning liquid recovery bag FB but is arranged in the bucket, that is, when the other end of the recycling pipe 8 is an open end, the liquid in the internal space 12h of the filter 10 can also be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6 by the same method. That is, when the other end of the recycling pipe 8 is an open end, the flow rate adjustment mechanism 8c is opened, and the cleaning liquid supply pipe liquid delivery part 6p provided in the cleaning liquid supply pipe 6 is operated in the same way as the above method. Thus, the suction force generated by the cleaning liquid supply pipe liquid delivery part 6p can suck the liquid in the internal space 12h of the filter 10 into the cleaning liquid supply pipe 6, so that it can be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6.

[0250] Furthermore, when the following method is used, the liquid in the internal space 12 h of the main body 11 of the filter 10 and the liquid in the hollow fiber membranes 16 of the filter 10 and the pair of headers 13 and 14 can be recovered simultaneously.

[0251] First, both the vicinity where the pressure gauge P2 is provided (i.e., the cleaning liquid supply pipe 6) and the filtrate discharge port 11c of the filter 10 are opened to the atmosphere. The space between the cleaning liquid supply pipe liquid delivery portion 6p in the cleaning liquid supply pipe 6 and the cleaning liquid supply port 11b of the filter 10 is opened to the atmosphere by removing the pressurized gas supply portion or the like. In other words, the cleaning liquid supply port 11b of the filter 10 is opened to the atmosphere. Next, the filtrate discharge port 11c of the filter 10 is opened to the atmosphere. That is, the internal space 12h of the main body 11 of the filter 10 is also opened to the atmosphere. In this state, the filtrate supply pipe liquid delivery portion 3p provided in the filtrate supply pipe 3 is operated to suck liquid from the filter 10. Thus, due to the suction force, the liquid existing in the hollow fiber membrane 16 and the pair of manifolds 13 and 14 of the filter 10 and the liquid in the internal space 12h are sucked out through the filtrate discharge port 11c of the filter 10 connected to the filtrate supply pipe 3, so that the liquid can be recovered to the cleaning liquid recovery bag FB connected to the other end of the filtrate supply pipe 3. In addition, when the liquid in the filter 10 is discharged, the operation of the liquid delivery part 3p of the filtrate supply pipe is stopped.

[0252] <Implementing leak checks>

[0253] After the liquid in the filter 10 is drained by the method described above, a leakage check is performed.

[0254] First, the flow rate adjustment mechanism 8c is opened, and pressurized air is supplied from the pressurized gas supply unit GS into the circuit. As a result, pressurized air is supplied to the through-flow path 16h of the hollow fiber membrane 16 of the filter 10, so the pressure in the through-flow path 16h of the hollow fiber membrane 16 rises. Then, if it is confirmed by the pressure gauge P2 that the pressure in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 rises and reaches a predetermined pressure, the supply of gas from the pressurized gas supply unit GS is stopped. In addition, after the supply of gas is stopped, the flow rate adjustment mechanism 8c can be closed or kept open.

[0255] In addition, it is desirable that when the pressurized air is supplied from the pressurized gas supply unit GS to the circuit without opening the flow rate adjustment mechanism 8c, the filtrate supply pipe liquid delivery unit 3p is operated in a manner of sucking air from the filter 10 so that the pressure measured by the pressure gauge P1 is constant. This is because when there is liquid in the through-flow path 16h of the hollow fiber membrane 16, the pressure measured by the pressure gauge P1 may become higher than the pressure measured by the pressure gauge P2 by discharging the liquid to the internal space 12h of the main body 11 of the filter 10. Therefore, in order to reliably detect the leakage from the hollow fiber membrane 16 and the like to the internal space 12h and realize stable leakage inspection, it is desirable that during the period when the pressurized air is supplied from the pressurized gas supply unit GS to the circuit, the filtrate supply pipe liquid delivery unit 3p is operated in a manner of sucking air from the filter 10 so that the pressure measured by the pressure gauge P1 is constant. For example, it is desirable to operate the filtrate supply pipe liquid delivery unit 3p so that the pressure measured by the pressure gauge P1 is lower than the pressure measured by the pressure gauge P2.

[0256] Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are damaged, or the airtightness or liquidtightness between the internal space 12h and the pair of headers 13, 14 is poor, the pressurized gas leaks from the portion (the poor portion) into the through-flow path 16h of the hollow fiber membrane 16 or leaks into the internal space 12h from the pair of headers 13, 14. As a result, the pressure in the hollow fiber membrane 16 decreases, and therefore, by checking the change in the gas pressure measured by the pressure gauge P2, the leakage of the filter 10 can be confirmed.

[0257] If there is a defective portion and the pressurized gas flows into the internal space 12h, the pressure of the pressure gauge P2 decreases and the pressure of the pressure gauge P1 increases. Therefore, leakage can also be confirmed by the pressure of the pressure gauge P1.

[0258] In particular, by utilizing the pressure difference between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2, the pressure inside and outside the wall 16w of the hollow fiber membrane 16 can be compared to perform a leakage inspection, thereby improving the accuracy of the leakage inspection.

[0259] In addition, when the leak check is performed using the pressure of the pressure gauge P1, it is necessary to close the flow rate adjustment mechanism 8c in advance and stop the operation of the filtrate supply pipe liquid delivery section 3p provided in the filtrate supply pipe 3 and the connecting pipe liquid delivery section 9p provided in the connecting pipe 9 in advance while the pressurized gas from the pressurized gas supply section GS is not supplied. In addition, it is desirable to drive the filtrate supply pipe liquid delivery section 3p in order to keep the pressure measured by the pressure gauge P1 constant as described above while the gas is supplied from the pressurized gas supply section GS.

[0260] The locations where the pressure gauges P1 and P2 are installed are not limited to the above locations. The pressure gauge P1 may be installed at a location communicating with the internal space 12 h , and the pressure gauge P2 may be installed at a location communicating with the pair of headers 13 , 14 .

[0261] In addition, when the leakage check is completed, the inside of the hollow fiber membrane 16 of the filter 10 is in a pressurized state. Therefore, in preparation for the next step of cleaning, the pressure inside the hollow fiber membrane 16 is reduced after the leakage check is completed. For example, if the flow rate adjustment mechanism 7c is opened, the pressure can be quickly discharged, so the pressure inside the hollow fiber membrane 16 can be reduced in a short time.

[0262] (Other leak detection methods 1)

[0263] In addition to the above method, leakage inspection can also be performed by the following method.

[0264] like Fig.11 As shown, when the connection pipe 9 is provided with a pressurized gas supply unit GS, a leak check is performed by the following method. When the leak check is performed by this method, if there is no defective part, the gas does not enter the through-flow path 16h of the hollow fiber membrane 16. That is, since the leak check can be performed without the gas entering the through-flow path 16h of the hollow fiber membrane 16, there is an advantage that the air discharge operation after the leak check can be performed reliably and in a short time.

[0265] like Fig.11 As shown, a branch pipe 9b connected to the connecting pipe 9 is provided in the connecting pipe 9, and a pressurized gas supply unit GS for supplying pressurized gas during the leakage inspection operation is provided in the branch pipe 9b of the connecting pipe 9. In addition, a flow regulating mechanism 9c for closing or opening the branch pipe 9b is provided in the branch pipe 9b.

[0266] First, in each tube, a bag is connected to the end portion on the side not connected to the filter 10 as described below.

[0267] A cleaning liquid bag SB is connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB.

[0268] A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply pipe 6 instead of the waste liquid bag DB. In addition, the bag connected to the other end of the cleaning liquid supply pipe 6 may remain as the waste liquid bag DB, or may be simply arranged in a bucket or the like.

[0269] The bag connected to the other end of the cleaning liquid recovery pipe 7 may remain the cleaning liquid recovery bag FB, or may be changed to a waste liquid bag DB, or simply arranged in a bucket or the like.

[0270] As described above, when the bag is connected to each tube, all flow rate adjustment mechanisms provided in the tube are closed, and the operation of all the tube liquid delivery parts is stopped. Thus, all the tubes are in a closed state.

[0271] Next, in the filtrate supply pipe 3, the end portion connected to the filtrate supply port 20a of the concentrator 20 is removed from the filtrate supply port 20a, and connected to the cleaning liquid recovery bag FB.

[0272] Furthermore, the other end of the recycling pipe 8 is removed from the concentrated liquid bag CB and connected to the cleaning liquid recovery bag FB as an open end.

[0273] In addition, the other end of the filtrate supply pipe 3 and the other end of the recycling pipe 8 may be connected to the waste liquid bag DB, or may be simply arranged in a bucket or the like.

[0274] In addition, the tube connected to the concentrator 20 may be as follows.

[0275] The other end of the concentrated liquid pipe 4 is connected to a cleaning liquid recovery bag FB instead of the concentrated liquid bag CB. The other end of the waste liquid pipe 5 is connected to a cleaning liquid recovery bag FB instead of the waste liquid bag DB. In addition, the other end of the concentrated liquid pipe 4 can be connected to the waste liquid bag DB, or it can be simply placed in a bucket or the like. In addition, the other end of the waste liquid pipe 5 can be connected to the waste liquid bag DB, or it can be simply placed in a bucket or the like.

[0276] <Liquid discharge>

[0277] If the above preparations are completed (refer to Fig.11 ), when there is a possibility that liquid exists in the internal space 12h of the filter 10, the liquid in the internal space 12h of the filter 10 is discharged as follows.

[0278] First, open the flow adjustment mechanism 7c provided in the cleaning liquid recovery pipe 7. In addition, maintain the other flow adjustment mechanisms in a closed state and maintain all the pipe liquid delivery parts in a stopped state. In this state, pressurized gas is supplied from the pressurized gas supply unit GS. As a result, the internal space 12h of the filter 10 is pressurized, so the liquid in the internal space 12h of the main body 11 of the filter 10 is discharged into the hollow fiber membrane 16, and is recovered to the cleaning liquid recovery bag FB connected to the other end of the cleaning liquid recovery pipe 7 through the cleaning liquid recovery pipe 7. In addition, if the liquid in the internal space 12h of the main body 11 of the filter 10 is discharged, the supply of pressurized gas by the pressurized gas supply unit GS is stopped, and the flow adjustment mechanism 9c and the flow adjustment mechanism 7c are closed.

[0279] In addition, by operating the filtrate supply pipe liquid delivery part 3p, the liquid in the internal space 12h of the main body 11 of the filter 10 can be recovered not only to the cleaning liquid recovery bag FB connected to the other end of the cleaning liquid recovery pipe 7, but also to the cleaning liquid recovery bag FB connected to the other end of the filtrate supply pipe 3.

[0280] <Implementing leak checks>

[0281] After the liquid in the internal space 12h of the main body 11 of the filter 10 is discharged by the above-described method, a leakage check is performed.

[0282] First, the flow rate adjustment mechanism 7c provided in the cleaning liquid recovery pipe 7 is opened.

[0283] Next, the flow rate adjustment mechanism 9c provided in the branch pipe 9b is opened, and the pressurized gas is supplied from the pressurized gas supply unit GS to the branch pipe 9b. As a result, the pressurized air is supplied to the internal space 12h of the trunk 12 of the main body 11, and the pressure in the internal space 12h (in other words, the pressure in the connecting pipe 9 and the branch pipe 9b) rises. Then, if the pressure in the internal space 12h measured by the pressure gauge P1 reaches a certain pressure or more, the supply of pressurized gas by the pressurized gas supply unit GS is stopped, and the branch pipe 9b is closed by the flow rate adjustment mechanism 9c.

[0284] Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are damaged, or the airtightness or liquidtightness between the internal space 12h and the pair of headers 13 and 14 is poor, the pressurized gas leaks from the portion (the poor portion) into the through-flow path 16h of the hollow fiber membrane 16 or into the pair of headers 13 and 14. As a result, the pressure in the internal space 12h decreases, so by checking the change in the gas pressure measured by the pressure gauge P1, the leakage of the filter 10 can be confirmed.

[0285] Furthermore, when the leak check is performed by the above method, if there is no defective part, the gas will not enter the through-flow path 16h of the hollow fiber membrane 16. That is, since the leak check can be performed without the gas entering the through-flow path 16h of the hollow fiber membrane 16, the air exhaust operation after the leak check can be performed reliably and in a short time.

[0286] Furthermore, if the pressure gauge P2 is installed in advance, if there is a defective portion causing the pressurized gas to flow into the through-flow path 16h, the pressure of the pressure gauge P1 decreases and the pressure of the pressure gauge P2 increases. Therefore, leakage can also be confirmed by the pressure of the pressure gauge P2.

[0287] In particular, by utilizing the pressure difference between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2, the pressure inside and outside the wall 16w of the hollow fiber membrane 16 can be compared to perform a leakage inspection, thereby improving the accuracy of the leakage inspection.

[0288] The pressure gauges P1 and P2 may be temporarily installed during leakage inspection or always installed during filtration and concentration operations, etc. When always installed, pressure gauges capable of measuring both air pressure and hydraulic pressure are used as the pressure gauges P1 and P2.

[0289] In addition, when performing a leak check using the pressure of the pressure gauge P2, after the pressure in the internal space 12h measured by the pressure gauge P1 reaches a certain pressure or above, it is necessary to pre-close the flow adjustment mechanism 7c and pre-stop the operation of the cleaning liquid supply pipe delivery part 6p provided in the cleaning liquid supply pipe 6.

[0290] The locations where the pressure gauges P1 and P2 are installed are not limited to the above locations. The pressure gauge P1 may be installed at a location communicating with the internal space 12 h , and the pressure gauge P2 may be installed at a location communicating with the pair of headers 13 , 14 .

[0291] (Other leak detection methods 2)

[0292] In the above example, the case where the end of the filtrate supply pipe 3 connected to the filtrate supply port 20a of the concentrator 20 is removed from the filtrate supply port 20a to perform the leakage check is described. However, the leakage check may be performed while the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20. In this case, after the leakage check is completed, the preparatory cleaning can be performed immediately. In this case, the leakage check can also be performed as in the above example.

[0293] In addition, since the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20, the liquid cannot be discharged from the filtrate supply pipe 3 and the recirculation pipe 8. Therefore, when the liquid in the internal space 12h of the filter 10 is discharged, it can be discharged from the filtrate discharge port 11c of the filter 10 to which the filtrate supply pipe 3 is not connected. In addition, during this operation, it is also desirable to close the filtrate supply pipe 3 by the filtrate supply pipe liquid delivery portion 3p and to close the recirculation pipe 8 by the flow rate adjustment mechanism 8c in advance.

[0294] like Fig.15As shown in FIG. 1 , a pressurized gas supply unit GS is provided between the liquid delivery unit 6p of the cleaning liquid supply pipe and the filter 10 (near the pressure gauge P2). In addition, the method of providing the pressurized gas supply unit GS in the cleaning liquid supply pipe 6 is not particularly limited. For example, a branch flow path having a clamp or the like can be provided in advance in the cleaning liquid supply pipe 6, and the pressurized gas supply unit GS can be provided in the branch flow path.

[0295] First, in each tube, a bag is connected to the end portion on the side not connected to the filter 10 as described below.

[0296] A cleaning liquid bag SB is connected to the other end of the liquid supply tube 2 instead of the original liquid bag UB.

[0297] A cleaning liquid recovery bag FB is connected to the other end of the cleaning liquid supply pipe 6 instead of the waste liquid bag DB. In addition, the bag connected to the other end of the cleaning liquid supply pipe 6 may remain as the waste liquid bag DB, or may be simply arranged in a bucket or the like.

[0298] The bag connected to the other end of the cleaning liquid recovery pipe 7 may remain the cleaning liquid recovery bag FB, or may be changed to a waste liquid bag DB, or simply arranged in a bucket or the like.

[0299] As described above, when the bag is connected to each tube, all flow rate adjustment mechanisms provided in the tube are closed, and the operation of all the tube liquid delivery parts is stopped. Thus, all the tubes are in a closed state.

[0300] Next, the other end of the recycling pipe 8 is removed from the concentrated liquid bag CB and connected to the cleaning liquid recovery bag FB as an open end. In addition, the other end of the recycling pipe 8 can be connected to the waste liquid bag DB or simply arranged in a bucket or the like.

[0301] In addition, the tube connected to the concentrator 20 may be as follows.

[0302] The other end of the concentrated liquid pipe 4 is connected to a cleaning liquid recovery bag FB instead of the concentrated liquid bag CB. The other end of the waste liquid pipe 5 is connected to a cleaning liquid recovery bag FB instead of the waste liquid bag DB. In addition, the other end of the concentrated liquid pipe 4 can be connected to the waste liquid bag DB, or it can be simply placed in a bucket or the like. In addition, the other end of the waste liquid pipe 5 can be connected to the waste liquid bag DB, or it can be simply placed in a bucket or the like.

[0303] The pipe ap connecting the pressure gauge P1 and the filtrate discharge port 11c is provided with an external gas introduction part Ai for supplying external gas etc. to the filtrate discharge port 11c via a pipe. Furthermore, a flow rate adjustment mechanism ac is provided in the pipe connecting the external gas introduction part Ai and the pipe ap.

[0304] <Liquid discharge>

[0305] If the above preparations are completed (refer to Fig.15 ), when there is a possibility that liquid exists in the filter 10 (in the through flow path 16h of the hollow fiber membrane 16, in the pair of headers 13, 14, and in the internal space 12h), the liquid in the filter 10 is discharged as follows.

[0306] Open the flow regulating mechanism 7c provided in the cleaning liquid recovery pipe 7, connect a pressurized gas supply device or the like instead of the pressure gauge P2, and supply air from the pressurized gas supply device or the like to pressurize the circuit (i.e., the filter 10 and each tube). Thus, since the liquid in the hollow fiber membrane 16 and the pair of manifolds 13 and 14 of the filter 10 can be discharged through the raw liquid supply port 11a, the discharged liquid can be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery pipe 7. If the liquid in the filter 10 is discharged, close the flow regulating mechanism 7c. In addition, remove the pressurized gas supply device or the like and install the pressure gauge P2 again. In addition, as Fig.15 As shown, when the pressurized gas supply unit GS is connected to the cleaning liquid supply pipe 6, even if the pressurized gas is supplied from the pressurized gas supply unit GS, the liquid existing in the hollow fiber membrane 16 of the filter 10 and the pair of headers 13 and 14 can be recovered in the same manner.

[0307] In addition, in the case of the above method, the liquid in the internal space 12h of the filter 10 cannot be recovered. Therefore, when the liquid in the internal space 12h of the filter 10 is discharged, the following operation is performed before the above operation, so that the liquid in the internal space 12h can be recovered.

[0308] For example, the flow rate adjustment mechanism ac is opened, and the atmosphere can be introduced from the filtrate discharge port 11c through the pipe ap through the external gas inlet part Ai (or the pressure gauge P1 is removed). In this state, the cleaning liquid supply pipe liquid delivery part 6p provided in the cleaning liquid supply pipe 6 is operated to suck the liquid from the filter 10. Thus, the liquid in the internal space 12h of the filter 10 is also sucked by the suction force, so that it can be recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6. In this case, the filtrate supply pipe liquid delivery part 3p provided in the filtrate supply pipe 3 can also be operated together with the cleaning liquid supply pipe liquid delivery part 6p, or before the cleaning liquid supply pipe liquid delivery part 6p is operated, so as to suck the liquid from the filter 10. Thus, the liquid in the internal space 12h of the filter 10 can be recovered to the cleaning liquid recovery bag FB connected to the filtrate supply pipe 3. When the liquid in the filter 10 is discharged, the flow rate adjustment mechanism ac is closed (the pressure gauge P1 is installed again), and the operation of the cleaning liquid supply pipe liquid delivery portion 6p (and the filtrate supply pipe liquid delivery portion 3p) is stopped.

[0309] Furthermore, the liquid in the hollow fiber membrane 16 of the filter 10 can be discharged by operating as follows.

[0310] First, the cleaning liquid supply pipe 6, i.e., the cleaning liquid supply port 11b of the filter 10, is opened to the atmosphere by removing the pressure gauge P2 or the like. In this state, the filtrate supply pipe liquid delivery portion 3p provided in the filtrate supply pipe 3 is operated to suck liquid from the filter 10. Thus, due to the suction force, the liquid existing in the hollow fiber membrane 16 and the pair of manifolds 13 and 14 of the filter 10, and the liquid in the internal space 12h are sucked out through the filtrate discharge port 11c of the filter 10 connected to the filtrate supply pipe 3. Thus, the sucked liquid can be recovered to the cleaning liquid recovery bag FB connected to the other end of the waste liquid pipe 5 via the filtrate supply pipe 3, the concentrator 20, and the waste liquid pipe 5. In addition, if the concentrated liquid supply pipe liquid delivery portion 4p provided in the concentrated liquid pipe 4 is operated to suck liquid from the concentrator 20, the sucked liquid can be recovered to the cleaning liquid recovery bag FB connected to the other end of the concentrated liquid pipe 4. When the liquid in the filter 10 is drained, the pressure gauge P2 is installed again, and the operation of the filtrate supply pipe liquid supply section 3p (and the concentrate supply pipe liquid supply section 4p) is stopped.

[0311] In addition, by supplying pressurized gas from the pressurized gas supply unit GS and opening the flow rate adjustment mechanism 8c provided in the recirculation pipe 8, the liquid in the hollow fiber membrane 16 of the filter 10 can be discharged by the following method. That is, if pressurized gas is supplied from the pressurized gas supply unit GS in a state where the flow rate adjustment mechanism 8c is opened, the liquid in the hollow fiber membrane 16 of the filter 10 can be discharged to the internal space 12h of the main body 11 of the filter 10.

[0312] <Implementing leak checks>

[0313] After the liquid in the filter 10 is drained by the method described above, a leakage check is performed.

[0314] First, open the flow adjustment mechanism ac, and make the internal space 12h open to the atmosphere through the external gas inlet part Ai. In this state, pressurized air is supplied to the circuit from the pressurized gas supply part GS. As a result, pressurized air is supplied to the through-flow path 16h of the hollow fiber membrane 16 of the filter 10, so the pressure in the through-flow path 16h of the hollow fiber membrane 16 rises. Then, if it is confirmed by the pressure gauge P2 that the pressure in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 rises and reaches the specified pressure, the supply of gas from the pressurized gas supply part GS is stopped. In addition, after the supply of gas is stopped, the internal space 12h can remain open to the atmosphere, or it can be airtightly isolated from the outside through the flow adjustment mechanism ac and the external gas inlet part Ai.

[0315] In addition, when the pressurized air is supplied from the pressurized gas supply unit GS to the circuit without opening the internal space 12h to the atmosphere, it is desirable to operate the filter 10 by sucking air from the filter 10 through the filtrate supply pipe liquid delivery unit 3p so that the pressure measured by the pressure gauge P1 is constant. This is because when there is liquid in the through-flow path 16h of the hollow fiber membrane 16, the pressure measured by the pressure gauge P1 may become higher than the pressure measured by the pressure gauge P2 by discharging the liquid into the internal space 12h of the main body 11 of the filter 10. Therefore, in order to reliably detect leakage from the hollow fiber membrane 16 and the like to the internal space 12h and realize stable leakage inspection, when the pressurized air is supplied from the pressurized gas supply unit GS to the circuit, it is desirable to operate the filter 10 by sucking air from the filter 10 through the filtrate supply pipe liquid delivery unit 3p so that the pressure measured by the pressure gauge P1 is constant. For example, it is desirable to operate the filtrate supply pipe liquid delivery section 3p so that the pressure measured by the pressure gauge P1 becomes lower than the pressure measured by the pressure gauge P2.

[0316] When the pressure of the pressure gauge P3 provided in the liquid feeding section 3 p of the filtrate supply pipe rises, the concentrated liquid pipe liquid feeding section 4 p provided in the concentrated liquid pipe 4 is operated to suck air from the concentrator 20 .

[0317] Here, if the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 are damaged, or the airtightness or liquidtightness between the internal space 12h and the pair of headers 13, 14 is poor, the pressurized gas leaks from the portion (the poor portion) into the through-flow path 16h of the hollow fiber membrane 16 or leaks into the internal space 12h from the pair of headers 13, 14. As a result, the pressure in the hollow fiber membrane 16 decreases, and therefore, by checking the change in the gas pressure measured by the pressure gauge P2, the leakage of the filter 10 can be confirmed.

[0318] If there is a defective portion and the pressurized gas flows into the internal space 12h, the pressure of the pressure gauge P2 decreases and the pressure of the pressure gauge P1 increases. Therefore, leakage can also be confirmed by the pressure of the pressure gauge P1.

[0319] In particular, by utilizing the pressure difference between the pressure measured by the pressure gauge P1 and the pressure measured by the pressure gauge P2, the pressure inside and outside the wall 16w of the hollow fiber membrane 16 can be compared to perform a leakage inspection, thereby improving the accuracy of the leakage inspection.

[0320] In addition, when the leak check is performed using the pressure of the pressure gauge P1, during the period when the pressurized gas from the pressurized gas supply unit GS is not supplied, the internal space 12h is hermetically isolated from the outside by the flow rate adjustment mechanism ac and the external gas introduction unit Ai. In addition, it is necessary to close the flow rate adjustment mechanism 8c in advance, and stop the operation of the filtrate supply pipe liquid delivery unit 3p provided in the filtrate supply pipe 3 and the connecting pipe liquid delivery unit 9p provided in the connecting pipe 9 in advance.

[0321] The locations where the pressure gauges P1 and P2 are installed are not limited to the above locations. The pressure gauge P1 may be installed at a location communicating with the internal space 12 h , and the pressure gauge P2 may be installed at a location communicating with the pair of headers 13 , 14 .

[0322] In addition, when the leakage check is completed, the inside of the hollow fiber membrane 16 of the filter 10 is in a pressurized state. Therefore, in preparation for the next step of cleaning, the pressure inside the hollow fiber membrane 16 is reduced after the leakage check is completed. For example, if the flow rate adjustment mechanism 7c is opened, the pressure can be quickly discharged, so the pressure inside the hollow fiber membrane 16 can be reduced in a short time.

[0323] (Prepare for cleaning)

[0324] like Fig.12 As shown, once the leak inspection is completed, the preparatory cleaning operation is performed.

[0325] In the following Fig.11 The situation of preparing for cleaning from the state of is described below.

[0326] First, the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20, and then the flow rate adjustment mechanism 2c allows the cleaning liquid to flow in the liquid supply pipe 2. Thus, the cleaning liquid is supplied to the filter 10 through the liquid supply pipe 2 from the cleaning liquid bag SB connected to the liquid supply pipe 2.

[0327] In the above state, the cleaning liquid supply pipe liquid delivery part 6p provided in the cleaning liquid supply pipe 6 is operated to make the cleaning liquid flow out of the filter 10. Thus, the cleaning liquid flows from the raw liquid supply port 11a to the cleaning liquid supply port 11b, so that the pair of headers 13 and 14 and the through-flow path 16h of the hollow fiber membrane 16 of the hollow fiber membrane bundle 15 can be cleaned by the cleaning liquid. The cleaning liquid after cleaning the pair of headers 13 and 14 and the like is recovered in the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6.

[0328] Furthermore, the filtrate supply pipe liquid delivery part 3p is operated so that the cleaning liquid flows from the filtrate supply pipe 3 to the concentrator 20. Thus, the cleaning liquid passes through the hollow fiber membrane 16 and fills the internal space 12h of the main body 12, and then flows to the filtrate supply pipe 3 through the filtrate discharge port 11c and fills the filtrate supply pipe 3. Then, the cleaning liquid filling the filtrate supply pipe 3 flows into the concentrator 20 from the filtrate supply port 20a of the concentrator 20, and then is recovered from the waste liquid discharge port 20c of the concentrator 20 through the waste liquid pipe 5 to the cleaning liquid recovery bag FB.

[0329] In addition, when the liquid in the internal space 12h of the main body 11 of the filter 10 is discharged during the leakage inspection, in order to fill the internal space 12h with the cleaning liquid, it is desirable to perform the following operation. For example, the filtrate discharge port 11c near the pressure gauge P1, that is, the filtrate supply pipe 3 is not connected to the air in advance. As a result, the air in the internal space 12h can be discharged through the filtrate discharge port 11c, so that the internal space 12h can be filled with the cleaning liquid. In addition, when the cleaning liquid is supplied from the liquid supply pipe 2, if the filter 10 is turned upside down so that the filtrate discharge port 11c connected to the filtrate supply pipe 3 is closer to the upper side than the filtrate discharge port 11c connected to the pressure gauge P1, or the filter 10 is laid flat so that the filtrate discharge port 11c is facing the upper side, the internal space 12h can be filled with the cleaning liquid.

[0330] Thereafter, the concentrated liquid pipe liquid feeding section 4p provided in the concentrated liquid pipe 4 is operated to suck liquid from the concentrator 20. Thus, the cleaning liquid in the concentrator 20 is discharged from the concentrated liquid discharge port 20b, fills the concentrated liquid pipe 4, and is recovered in the cleaning liquid recovery bag FB.

[0331] By performing the above operation, the cleaning liquid can flow through the liquid supply pipe 2, the filter 10, the filtrate supply pipe 3, the concentrator 20, the concentrated liquid pipe 4, and the waste liquid pipe 5. That is, in the raw liquid treatment device 1C of this embodiment, the flow path for the raw liquid to flow can be cleaned during the filtration and concentration operation, and the cleaning liquid can be filled in the filter 10, the concentrator 20, and the above-mentioned pipes.

[0332] When the recirculation pipe 8 and the connection pipe 9 are filled with the cleaning liquid, the following operation may be performed.

[0333] For example, when the recirculation pipe 8 and the connection pipe 9 are to be filled, the flow rate adjustment mechanism 8c provided in the recirculation pipe 8 is opened, and the connection pipe liquid feeding portion 9p provided in the connection pipe 9 is driven. In this state, if the cleaning liquid is supplied from the cleaning liquid bag SB connected to the connection pipe 9 and the cleaning liquid is recovered in the cleaning liquid recovery bag FB connected to the recirculation pipe 8, the recirculation pipe 8 and the connection pipe 9 can be filled with the cleaning liquid.

[0334] The cleaning liquid recovery pipe 7 is a path for recovering the cleaning liquid during the filter cleaning implemented during the filtering and concentrating operation. Therefore, even if air remains in the cleaning liquid recovery pipe 7, the air usually does not enter the filter 10 during the filtering and concentrating operation, and will not affect the filtering and concentrating operation. Therefore, it is not necessarily necessary to fill it with cleaning liquid. However, if air remains in the cleaning liquid recovery pipe 7, and the original liquid bag UB is emptied, etc., so that the liquid supply pipe 2 and the filter 10 become negative pressure, the air in the cleaning liquid recovery pipe 7 may flow back to the liquid supply pipe 2 and the filter 10. Therefore, in order to reduce the possibility of air entering the filter 10, it is expected that the cleaning liquid recovery pipe 7 is also filled with cleaning liquid in advance.

[0335] If the cleaning liquid recovery pipe 7 is to be filled with cleaning liquid, the following operation may be performed.

[0336] First, the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7 is arranged at a lower position than the cleaning liquid bag SB connected to the liquid supply tube 2. In this state, the flow rate adjustment mechanism 2c provided in the liquid supply tube 2 and the flow rate adjustment mechanism 7c provided in the cleaning liquid recovery tube 7 are opened. Thus, the cleaning liquid flows from the cleaning liquid bag SB connected to the liquid supply tube 2 to the cleaning liquid recovery tube 7 through the liquid supply tube 2, so if the cleaning liquid is recovered to the cleaning liquid recovery bag FB connected to the cleaning liquid recovery tube 7, the cleaning liquid recovery tube 7 can also be filled with the cleaning liquid.

[0337] In addition, as described above, when the filtrate supply pipe 3 is removed from the filtrate supply port 20a of the concentrator 20 and a leak check is performed, it is necessary to connect the filtrate supply pipe 3 to the filtrate supply port 20a of the concentrator 20 before preparing for cleaning. In this case, in order to prevent air from entering the concentrator 20, it is desirable to fill the filtrate supply pipe 3 with a cleaning liquid in advance. For example, before connecting the filtrate supply pipe 3 to the filtrate supply port 20a of the concentrator 20, the flow rate adjustment mechanism 2c provided in the liquid supply pipe 2 is opened, and the filtrate supply pipe liquid delivery part 3p provided in the filtrate supply pipe 3 is driven. Thus, the cleaning liquid flows from the cleaning liquid bag SB connected to the liquid supply pipe 2 to the filtrate supply pipe 3, and the filtrate supply pipe 3 can be filled with the cleaning liquid. Thus, when the filtrate supply pipe 3 is connected to the filtrate supply port 20a of the concentrator 20, it is possible to suppress the entry of air into the concentrator 20.

[0338] On the other hand, when the cleaning liquid is filled into the circuit, if there is no cleaning liquid in the through flow path 16h of the hollow fiber membrane 16 of the filter 10, the cleaning liquid cannot be sucked into the filtrate supply pipe 3 even if the flow rate adjustment mechanism 2c is opened and the filtrate supply pipe 3 is operated.

[0339] Furthermore, when the pressurized gas is supplied to the through-flow passage 16h of the hollow fiber membrane 16 of the filter 10 and a leak check is performed (i.e., if the pressurized gas exists in the through-flow passage 16h of the hollow fiber membrane 16 of the filter 10), the pressurized gas may flow back to the cleaning liquid bag SB when the flow rate adjustment mechanism 2c is opened. Generally speaking, since the cleaning liquid bag SB is not assumed to be pressurized, the cleaning liquid bag SB may be damaged by the pressure of the pressurized air.

[0340] Therefore, when there is no cleaning liquid in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10, or when the pressurized gas is supplied to the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 and a leak check is performed, the following operation is performed before opening the flow adjustment mechanism 2c. Specifically, the cleaning liquid supply pipe liquid delivery part 6p is driven while the flow adjustment mechanism 2c is kept closed. As a result, the pressurized gas in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 is discharged to the cleaning liquid recovery bag FB connected to the cleaning liquid supply pipe 6. At this time, the pressure of the pressure gauge P2 connected to the cleaning liquid supply pipe 6 is measured in advance, and the flow adjustment mechanism 2c is opened after confirming that the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 has become sufficiently decompressed (near atmospheric pressure). As a result, the filling operation in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 can be performed without the pressurized gas flowing back to the cleaning liquid bag SB.

[0341] In addition, the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 can also be depressurized by the following method. The flow regulating mechanism 7c is opened while the flow regulating mechanism 2c is kept closed and the liquid delivery part 6p of the cleaning liquid supply pipe is stopped. At this time, the pressure of the pressure gauge P2 connected to the cleaning liquid supply pipe 6 is measured in advance, and the flow regulating mechanism 2c is opened (the flow regulating mechanism 7c is closed) after confirming that the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 has become sufficiently depressurized (near atmospheric pressure). In this way, the filling operation in the through-flow path 16h of the hollow fiber membrane 16 of the filter 10 can be carried out without the pressurized gas flowing back to the cleaning liquid bag SB.

[0342] (Filtration and concentration operation)

[0343] If the cleaning operation is completed, the filtration and concentration operation is performed.

[0344] like Fig.13 As shown, in the filtration and concentration operation of the raw liquid treatment device 1C of this embodiment, from the state of preparing for the cleaning operation, the concentrated liquid bag CB is connected to the concentrated liquid pipe 4 instead of the cleaning liquid recovery bag FB, and the waste liquid bag DB is connected to the waste liquid pipe 5 instead of the cleaning liquid recovery bag FB.

[0345] Furthermore, the concentrated liquid bag CB to which the concentrated liquid tube 4 is connected is also connected to the recycling tube 8, and the recycling tube 8 is closed by the flow rate adjustment mechanism 8c.

[0346] On the other hand, a stock liquid bag UB is connected to the liquid supply pipe 2 instead of the cleaning liquid bag SB. Moreover, the flow rate adjustment mechanism 2c is used to maintain the state in which the liquid can flow in the liquid supply pipe 2, and on the other hand, the operation of the cleaning liquid supply pipe liquid delivery part 6p and the connecting pipe liquid delivery part 9p is stopped to seal the cleaning liquid supply pipe 6 and the connecting pipe 9 so that the liquid cannot flow. In addition, the cleaning liquid recovery pipe 7 is sealed by the flow rate adjustment mechanism 7c.

[0347] In the above state, the filtrate supply pipe liquid feeding part 3p is operated so that the filtrate flows from the filter 10 to the concentrator 20, and the concentrated liquid pipe liquid feeding part 4p is operated so that the concentrated liquid flows from the concentrator 20 to the concentrated liquid bag CB.

[0348] Thus, the stock solution is supplied from the stock solution bag UB to the filter 10 through the liquid supply pipe 2. The supplied stock solution is filtered by the filter 10, and the generated filtrate is supplied to the concentrator 20 through the filtrate supply pipe 3. Then, the filtrate supplied to the concentrator 20 is concentrated by the concentrator 20, and the generated concentrated liquid is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5.

[0349] (About filter cleaning)

[0350] In the middle of the filtration and concentration operation of the raw liquid treatment device 1C of this embodiment, the plurality of hollow fiber membranes 16 of the hollow fiber membrane bundle 15 of the filter 10 may be cleaned. Fig.13 In the process, the flow rate adjustment mechanism 2c is used to close the liquid so that the liquid cannot flow in the liquid supply pipe 2. In addition, the operation of the filtrate supply pipe liquid supply part 3p and the concentrate supply pipe liquid supply part 4p is stopped to function as a clamp.

[0351] The connecting pipe liquid feeding part 9p provided in the connecting pipe 9 is operated so that the cleaning liquid flows from the cleaning liquid bag SB connected to the connecting pipe 9 to the filtrate supply pipe 3. Thus, the cleaning liquid supplied to the filtrate supply pipe 3 is supplied from the filtrate discharge port 11c to the internal space 12h of the main body 11 of the filter 10, and the cleaning liquid flows into the through-flow path 16h of the hollow fiber membrane 16 by the hydraulic pressure of the connecting pipe liquid feeding part 9p. Thus, the cleaning liquid passes through the hollow fiber membrane 16 in the direction opposite to the direction in which the filtrate passes through the hollow fiber membrane 16. Moreover, since the cleaning liquid is pushed into the through-flow path 16h of the hollow fiber membrane 16 by the hydraulic pressure of the connecting pipe liquid feeding part 9p, the clogging of the hollow fiber membrane 16 can be effectively eliminated.

[0352] At this time, the cleaning liquid supply pipe liquid delivery part 6p provided in the cleaning liquid supply pipe 6 is operated to make the cleaning liquid flow out from the filter 10. In addition, the cleaning liquid recovery pipe 7 is opened by the flow adjustment mechanism 7c provided in the cleaning liquid recovery pipe 7. Then, the operation of the cleaning liquid supply pipe liquid delivery part 6p is adjusted so that a part of the cleaning liquid pushed into the through-flow path 16h of the hollow fiber membrane 16 flows to the cleaning liquid recovery bag FB provided in the cleaning liquid supply pipe 6, and the remaining cleaning liquid flows to the cleaning liquid recovery bag FB provided in the cleaning liquid recovery pipe 7. Thus, since the cleaning liquid pushed into the through-flow path 16h of the hollow fiber membrane 16 can flow in the through-flow path 16h of the hollow fiber membrane 16, the cleaning liquid can be recovered to the cleaning liquid recovery bag FB provided in the cleaning liquid supply pipe 6 and the cleaning liquid recovery pipe 7.

[0353] (Re-enrichment Operation)

[0354] When the concentrated liquid obtained by the filtration concentration operation is further concentrated, a re-concentration operation is performed.

[0355] In the re-concentration operation, first, the flow rate adjustment mechanism 2c closes the liquid supply pipe 2 from the state of performing the concentration and filtration operation. Accordingly, the operation of the filtrate supply pipe liquid delivery part 3p and the concentrated liquid pipe liquid delivery part 4p is stopped. Thus, the flow of liquid in the device is stopped.

[0356] If the liquid stops flowing, the flow rate adjustment mechanism 8 c of the recirculation pipe 8 allows the liquid to flow in the recirculation pipe 8 .

[0357] In this state, the filtrate supply pipe liquid delivery portion 3p is operated to generate a flow toward the concentrator 20 in the filtrate supply pipe 3, and the concentrated liquid pipe liquid delivery portion 4p is operated to cause the concentrated liquid to flow from the concentrator 20 to the concentrated liquid bag CB.

[0358] Thus, the concentrated liquid is supplied from the concentrated liquid bag CB to the concentrator 20 through the recycling pipe 8 and the filtrate supply pipe 3, and the re-concentrated liquid further concentrated by the concentrator 20 is recovered to the concentrated liquid bag CB through the concentrated liquid pipe 4. On the other hand, the water separated from the concentrated liquid is recovered to the waste liquid bag DB through the waste liquid pipe 5. That is, a concentrated liquid (re-concentrated liquid) with a higher concentration ratio can be obtained.

[0359] (Dry Liquid Treatment Device 1D of Another Embodiment)

[0360] A raw liquid treatment apparatus 1D of another embodiment is different from the raw liquid treatment apparatus 1C in that the position where the connecting pipe 9 is connected to the filtrate supply pipe 3 is changed, and a flow rate adjustment mechanism 9f is provided on the connecting pipe 9 instead of the connecting pipe liquid feeding portion 9p.

[0361] like Fig.14As shown in FIG. 1 , in the stock liquid treatment apparatus 1D, a connection pipe 9 is connected between the filtrate supply pipe liquid feeding section 3p in the filtrate supply pipe 3 and the concentrator 20. With such a configuration, by changing the running direction of the filtrate supply pipe liquid feeding section 3p, the cleaning liquid can be supplied from the cleaning liquid bag SB connected to the connection pipe 9 to the filter 10. Thus, there is no need to provide a liquid feeding section (connection pipe liquid feeding section 9p) for supplying the cleaning liquid from the cleaning liquid bag SB connected to the connection pipe 9 to the filter 10 as in the stock liquid treatment apparatus 1C.

[0362] That is, as described above, in the raw liquid treatment apparatus 1C, in order to push the cleaning liquid supplied from the cleaning liquid bag SB connected to the connection pipe 9 into the hollow fiber membrane 16, it is necessary to operate the connection pipe liquid feeding section 9p. However, in the raw liquid treatment apparatus 1D, generally speaking, the cleaning liquid supplied from the cleaning liquid bag SB connected to the connection pipe 9 can be pushed into the hollow fiber membrane 16 by simply reversing the operating direction of the filtrate supply pipe liquid feeding section 3p that transports the filtrate from the filter 10 to the concentrator 20.

[0363] In addition, in the raw liquid treatment device 1D, a flow adjustment mechanism 3c or a flow adjustment mechanism 5c is pre-set in the filtrate supply pipe 3 from the position connected to the connecting pipe 9 to the concentrator 20 or in the waste liquid pipe 5. Therefore, when switching from the filtration and concentration treatment to the filter cleaning, if either the flow adjustment mechanism 3c or the flow adjustment mechanism 5c is closed, the cleaning liquid supplied by the cleaning liquid bag SB connected to the connecting pipe 9 can be prevented from flowing to the concentrator 20.

[0364] Furthermore, in the raw liquid treatment apparatus 1D, the cleaning liquid cannot be delivered from the cleaning liquid bag SB connected to the connection pipe 9 to the concentrator 20 by the filtrate supply pipe delivery portion 3p. However, if the flow rate adjustment mechanism 9f of the connection pipe 9 is opened and the concentrated liquid pipe delivery portion 4p provided in the concentrated liquid pipe 4 is operated to suck the liquid from the concentrator 20, the cleaning liquid can be delivered from the cleaning liquid bag SB connected to the other end of the connection pipe 9 to the concentrator 20 by the negative pressure generated by the concentrated liquid pipe delivery portion 4p. Therefore, even with the configuration of the raw liquid treatment apparatus 1D, the concentrator 20 can be cleaned.

[0365] (Regarding another filter 10B)

[0366] In the above description, the case where the filter 10 is used in which the filter element is the hollow fiber membrane 16 is described as a representative example, but a filter element formed by stacking flat-plate filter membranes may also be used as the filter element. Fig.16 The structure of a filter element (laminated type) in which filtration membranes are laminated will be described.

[0367] In addition, Fig.16In the embodiment of the invention, the filter 10 (refer to Figure 5 ) Components having substantially the same configuration and function as those of the filter 10 are given the same reference numerals. In addition, the description of the parts having the same configuration and function as those of the filter 10 is appropriately omitted.

[0368] like Fig.16 As shown, the filter 10B has substantially the same structure as a filter having a known laminated filter component (for example, a hemodialyzer used for dialysis), and includes a main body 11, a filter membrane 17b disposed in the main body 11, and a retaining member 17a.

[0369] Similar to the hollow fiber membrane 16 , the filtration membrane 17 b has a function of not allowing solid components such as cells and gases to pass through but allowing liquids to pass through.

[0370] The filter membrane 17b is placed in the main body 11 in a state where a rectangular sheet of membrane is folded into a plurality of layers of corrugated shapes (folded outward and inward repeatedly), and the rectangular sheet is bonded to the main body 11 of the filter 10B, so that the main body 11 is separated into two spaces (space 17f and space 17h). Furthermore, the separated space 17f and space 17h in the main body 11 are separated in a liquid-tight and air-tight manner by the filter membrane 17b.

[0371] In addition, Fig.16 In the embodiment, the filter membrane 17b is folded into a corrugated state, but the filter membrane 17b may also be flat. That is, the filter membrane 17b is not particularly limited in shape and configuration as long as it can separate the space in the main body 11 into two liquid-tight and air-tightly separated spaces.

[0372] (Holding member 17a)

[0373] The holding member 17a is a member provided to prevent the filter membranes 17b from contacting each other due to the pressure of each other when the filter membranes 17b are folded into a corrugated shape, thereby reducing the filtration efficiency. The holding member 17a is inserted between the folded filter membranes 17b. The holding member 17a is not particularly limited in terms of material and shape, as long as it is provided in a manner that can exert the above-mentioned function. Fig.16 Although the filter 10B is disposed on the space 17f side, it can also be disposed on either the space 17h side or the space 17f side. In addition, the holding member 17a can also be disposed on both the space 17h side and the space 17f side. The holding member 17a can be inserted into an appropriate position in accordance with the conditions for using the filter 10B.

[0374] (Each port)

[0375] Four ports are provided on the outer surface of the main body 11. Two of the four ports are provided on the surface in contact with the space 17h, and the remaining two are provided on the surface in contact with the space 17f. In other words, the two ports (on Fig.16 The ports 11a and 11b in the figure are connected to the space 17h, and the other two ports (in Fig.16 The ports 11a, 11c in the figure are connected to the space 17f. Among the ports connected to the space 17h, one is the above-mentioned raw liquid supply port 11a, and the other is the cleaning liquid supply port 11b. In addition, the two ports connected to the space 17f are the filtrate discharge port 11c. Moreover, similar to the filter 10, each port 11a~11c of the main body 11 is connected to a tube. For example, one end of the liquid supply tube 2 is connected to the raw liquid supply port 11a, one end of the filtrate supply tube 3 is connected to the filtrate discharge port 11c, and one end of the cleaning liquid supply tube 6 is connected to the cleaning liquid supply port 11b.

[0376] Therefore, if the filter 10B is provided instead of the filter 10 , the raw liquid can be filtered in the same manner as the filter 10 , and the filter member 17 can be cleaned and inspected for leakage in the same manner as the filter 10 .

[0377] Industrial Applicability

[0378] The operating method of the raw liquid processing device of the present invention is suitable for cleaning filters in devices that filter and concentrate pleural and abdominal effusions containing cells, blood during surgery or bloodletting to obtain concentrated liquids, and devices that purify and reuse plasma such as plasma from waste liquid plasma of blood exchange.

[0379] Description of Reference Numerals

[0380] 1. Raw liquid treatment device

[0381] 2 Liquid supply pipe

[0382] 2c Flow adjustment mechanism

[0383] 2p Liquid delivery pipe

[0384] 3 Filtrate supply pipe

[0385] 3c Flow adjustment mechanism

[0386] 3p Filtrate supply pipe liquid delivery part

[0387] 4 Concentrate tube

[0388] 4p Concentrate tube delivery unit

[0389] 5 Waste pipe

[0390] 5c Flow adjustment mechanism

[0391] 6 Cleaning fluid supply pipe

[0392] 6c Flow adjustment mechanism

[0393] 6p Cleaning liquid supply pipe delivery part

[0394] 7 Cleaning fluid recovery pipe

[0395] 7c Flow adjustment mechanism

[0396] 7p Cleaning liquid recovery pipe liquid delivery part

[0397] 8 Recirculation pipe

[0398] 8c Flow adjustment mechanism

[0399] 9 Connecting pipe

[0400] 9c Flow adjustment mechanism

[0401] 9f Flow adjustment mechanism

[0402] 9p Connecting tube liquid delivery part

[0403] 10 Filters

[0404] 10B Filter

[0405] 11 Main body

[0406] 11a Stock solution supply port

[0407] 11b Cleaning fluid supply port

[0408] 11c Filtrate discharge port

[0409] 12 Trunk

[0410] 12h Internal space

[0411] 13. Manifold

[0412] 14 Header

[0413] 15 Hollow fiber membrane bundle

[0414] 16 Hollow fiber membrane

[0415] 16h Through flow

[0416] 16w wall

[0417] 17a Retaining parts

[0418] 17b Filter membrane

[0419] 17h Space

[0420] 17f Space

[0421] 20 Concentrator

[0422] 20a Filtrate supply port

[0423] 20b Concentrate discharge port

[0424] 20c Waste liquid outlet

[0425] UB stock solution bag

[0426] CB Concentrate Bag

[0427] DB waste bag

[0428] SB Cleaning Fluid Bag

[0429] FB cleaning fluid recovery bag

[0430] P1 Pressure Gauge

[0431] P2 Pressure Gauge

[0432] P3 Pressure Gauge

[0433] GS Pressurized gas supply.

Claims

1. A method for operating a raw liquid treatment device, the raw liquid treatment device comprising: a filter having a filtering component for filtering raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid, wherein the method for operating the raw liquid treatment device is characterized in that: The filter has: A main body having an internal space separated by a flow path for supplying the raw liquid and the filter component; A stock solution supply port and a cleaning solution supply port are separated from the internal space of the main body in a liquid-tight manner and are respectively connected to both ends of a flow path for supplying the stock solution; A filtrate discharge port is communicated with the internal space, During the filtration and concentration operation, the raw liquid is supplied to the raw liquid supply port while the cleaning liquid supply port is closed. During the cleaning operation, the cleaning liquid supply port is opened to allow the cleaning liquid to flow between the raw liquid supply port and the cleaning liquid supply port.

2. The method for operating the raw liquid treatment device according to claim 1, characterized in that: The filter element of the filter is a plurality of hollow fiber membranes which are bundled together at one end and at the other end. The internal space of the main body is a space for accommodating the hollow fiber membrane. A pair of headers are provided, each of which is connected to both ends of the through-flow passage of the plurality of hollow fiber membranes and is a space that is liquid-tightly isolated from the internal space of the main body and has a larger cross-sectional area than the through-flow passage. Each header is provided with either the raw liquid supply port or the cleaning liquid supply port. A negative pressure generating unit for generating negative pressure in the flow path is provided in the flow path connected to the raw liquid supply port or the cleaning liquid supply port. During the cleaning operation, the negative pressure generating unit is operated while the cleaning liquid is caused to flow between the raw liquid supply port and the cleaning liquid supply port.

3. The method for operating a raw liquid treatment device according to claim 1 or 2, characterized in that: A negative pressure generating unit for generating negative pressure in the flow path connected to the stock solution supply port is provided in the flow path, The filter has a filtrate discharge port communicating with the internal space. During the cleaning operation, the negative pressure generating unit is operated while the cleaning liquid is allowed to flow through the filtrate discharge port.

4. A method for operating a raw liquid treatment device, the raw liquid treatment device comprising: a filter having a filtering component for filtering raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid, wherein the method for operating the raw liquid treatment device is characterized in that: The filter has: A main body having an internal space separated by a flow path for supplying the raw liquid and the filter component; A stock solution supply port and a cleaning solution supply port are separated from the internal space of the main body in a liquid-tight manner and are respectively connected to both ends of a flow path for supplying the stock solution; A filtrate discharge port is communicated with the internal space, During the filtration and concentration operation, the raw liquid is supplied to the raw liquid supply port while the cleaning liquid supply port is closed. During the cleaning operation, the cleaning liquid is supplied to the internal space of the filter through the filtrate discharge port while the filtrate supply flow path connecting the filtrate discharge port and the filtrate supply port of the concentrator is closed and the stock liquid supply port is opened or both the stock liquid supply port and the cleaning liquid supply port are opened.

5. The method for operating the raw liquid treatment device according to claim 4, characterized in that: A negative pressure generating unit for generating negative pressure in the flow path connected to the stock solution supply port is provided in the flow path, During the cleaning operation, the cleaning liquid is supplied to the filtrate discharge port and the negative pressure generating unit is operated.

6. The method for operating a raw liquid treatment device according to claim 4 or 5, characterized in that: During the filtration and concentration operation, a liquid delivery unit provided in a flow path communicating with the filtrate discharge port is operated to discharge the filtrate from the filter to the concentrator. During the cleaning operation, the operation of the liquid feeding unit provided in the flow path communicating with the filtrate discharge port is stopped.

7. A method for operating a raw liquid treatment device, the raw liquid treatment device comprising: a filter having a filtering component for filtering raw liquid; and a concentrator supplied with a filtrate filtered by the filter and concentrating the filtrate to form a concentrated liquid, wherein the method for operating the raw liquid treatment device is characterized in that: The filter has: A main body having an internal space separated by a flow path for supplying the raw liquid and the filter component; A stock solution supply port and a cleaning solution supply port are separated from the internal space of the main body in a liquid-tight manner and are respectively connected to both ends of a flow path for supplying the stock solution; A filtrate discharge port is communicated with the internal space, A filtrate supply portion is provided in the flow path connected to the filtrate discharge port, and the filtrate supply portion is provided in a cleaning liquid supply portion for supplying a cleaning liquid to the filtrate discharge port and / or in a filtrate supply flow path connecting the filtrate discharge port and the filtrate supply port of the concentrator, During the filtration and concentration operation, the raw liquid is supplied to the raw liquid supply port while the cleaning liquid supply port is closed. During the cleaning operation, the cleaning liquid supply unit pushes the cleaning liquid into the inner space of the filter through the filtrate discharge port or the filtrate supply unit while closing the filtrate supply channel connecting the filtrate discharge port and the filtrate supply port of the concentrator.

8. The method for operating the raw liquid treatment device according to claim 7, characterized in that: A liquid delivery unit is provided in the flow path connected to the stock liquid supply port or the cleaning liquid supply port, which allows the cleaning liquid to flow out from the flow path connected to the stock liquid supply port or the cleaning liquid supply port. During the cleaning operation, the cleaning liquid supply port and / or the raw liquid supply port are opened, and the liquid feeding unit is operated so that the cleaning liquid flows out from the raw liquid supply port and / or the cleaning liquid supply port.

9. The method for operating a raw liquid treatment device according to claim 7 or 8, characterized in that: During the filtration and concentration operation, a filtrate feeding section provided in a filtrate supply flow path connecting the filtrate discharge port and the filtrate supply port of the concentrator is operated to discharge the filtrate from the filter to the concentrator. During the cleaning operation, the filtrate supply flow path is closed by the filtrate feeding unit.

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