A signal processing system based on planar architecture array

Abstract

The present invention discloses a signal processing system based on a planar architecture array, comprising a planar array architecture functional module, a recording intervention module and an analysis module, wherein the planar array architecture functional module comprises an array support platform and multiple functional components, and the functional components are fixed on the array support platform; the recording intervention module comprises a recording intervention component corresponding to the functional component, and the recording intervention component is used to record acquisition information, and the functional component is connected to the recording intervention component corresponding to the functional component; the analysis module is used to obtain the acquisition information recorded by the recording intervention component, and execute the corresponding analysis method to analyze the acquisition information, obtain the analysis results and display them. By setting multiple functional components and corresponding recording intervention modules, the signal processing system provided in this embodiment can be flexibly combined according to actual needs to meet the needs of multiple signal types and multiple analyte types.

Description

Technical Field

[0001] The present invention relates to the field of signal processing technology, and in particular to a signal processing system based on a planar architecture array. Background Art

[0002] In current biomedical research, simultaneous monitoring of multiple sites within living tissue using array electrodes can provide a deeper and more comprehensive understanding of physiological and / or pathological phenomena associated with that tissue and the underlying biological mechanisms. However, in recent years, the widespread application of various array electrode systems has also gradually exposed some practical problems or shortcomings, such as a lack of flexibility that makes it difficult to cope with complex recording scenarios or paradigms, and high costs that lead to high recording and analysis costs.

[0003] In the process of realizing the present invention, it was found that there are at least the following technical problems in the prior art: traditional array electrode recording platforms are mostly customized integrated assemblies, and the signal type is relatively single, that is, the recording electrodes used are electrophysiological electrodes only for extracellular electrical signals or electrochemical electrodes only for specific analytes, and cannot cope with recording scenarios with multiple signal types and multiple analyte types. Summary of the Invention

[0004] The present invention provides a signal processing system based on a planar architecture array to solve the technical problem that traditional array electrode recording platforms cannot cope with recording scenarios with multiple signal types and multiple analyte types, and to achieve flexible combination of components in the signal processing system to cope with scenarios with multiple signal types and multiple analyte types.

[0005] The present invention provides a signal processing system based on a planar architecture array, comprising a planar array architecture function module, a recording intervention module, and an analysis module, wherein:

[0006] The planar array architecture functional module includes an array support platform and a plurality of functional components, wherein the functional components are fixed on the array support platform;

[0007] The recording intervention module includes a recording intervention component corresponding to the functional component, the recording intervention component is used to record the collected information, and the functional component is connected to the recording intervention component corresponding to the functional component;

[0008] The analysis module is used to obtain the collected information recorded by the recording intervention component, and execute a corresponding analysis method to analyze the collected information, obtain analysis results and display them.

[0009] Optionally, further, the functional components are electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes and drug delivery tubes, and correspondingly, the recording intervention module is a multi-channel electrochemical recording unit, a multi-channel electrophysiological recording unit, a stimulator and a charger.

[0010] Optionally, further, the array support platform includes a planar matrix and a recording slot, wherein:

[0011] The planar matrix includes a plurality of array sites for carrying the functional components;

[0012] The recording tank is arranged below the array support platform and is used for placing samples to be analyzed.

[0013] Optionally, further, the planar array architecture functional module further includes a micromanipulator, which is fixedly connected to the outer shell of the planar matrix and is used to control the movement of the planar matrix.

[0014] Optionally, further, the array support platform further includes a coordinate base plate, and the coordinate information on the coordinate base plate corresponds to the coordinate information of the array sites on the plane matrix.

[0015] Optionally, further, the signal processing system further includes a temperature-controlled perfusion module, which includes: a temperature controller, a water inlet pipe, a water outlet pipe and a surge pump;

[0016] The temperature controller is used to heat the perfusion fluid;

[0017] The surge pump is used to control the heated perfusion fluid to flow through the recording tank via the water inlet pipe and the water outlet pipe.

[0018] Optionally, further, the temperature controller includes: a heating tube, a temperature sensitive probe and a temperature control host, wherein:

[0019] The heating pipe is connected to the water inlet pipe, and the water inlet pipe, the water outlet pipe and the temperature sensitive probe are all placed in the recording tank;

[0020] The temperature-sensitive probe is used to detect the actual temperature of the perfusion fluid and provide feedback.

[0021] Optionally, the signal processing system further includes an imaging observation module, which includes: an operating platform, an imaging information acquisition component and an imaging unit, wherein:

[0022] The operating platform is provided with an array of screw holes, and the imaging information acquisition component and the imaging component are fixed to the operating platform through corresponding screw holes;

[0023] The imaging information acquisition component is used to obtain imaging information of the sample to be analyzed;

[0024] The imaging component is used to generate a target image based on the imaging information for display.

[0025] Optionally, further, the imaging information acquisition component includes a camera and a microscope.

[0026] Optionally, further, executing a corresponding analysis method to analyze the collected information, obtaining and displaying analysis results, includes:

[0027] Executing a corresponding analysis method to analyze the collected information to obtain signal evaluation parameters;

[0028] Determine display information in the form of a heat map corresponding to the signal evaluation parameter, and perform display based on the display information.

[0029] An embodiment of the present invention provides a signal processing system based on a planar architecture array, including a planar array architecture functional module, a recording intervention module and an analysis module, wherein the planar array architecture functional module includes an array support platform and multiple functional components, and the functional components are fixed on the array support platform; the recording intervention module includes a recording intervention component corresponding to the functional component, and the recording intervention component is used to record the collected information, and the functional component is connected to the recording intervention component corresponding to the functional component; the analysis module is used to obtain the collected information recorded by the recording intervention component, and execute the corresponding analysis method to analyze the collected information, obtain the analysis results and display them. By setting multiple functional components and corresponding recording intervention modules, the signal processing system provided by this embodiment can flexibly combine the modules therein according to actual needs, thereby realizing the scenario requirements of multiple signal types and multiple analyte types.

[0030] It should be understood that the content described in this section is not intended to identify the key or important features of the embodiments of the present invention, nor is it intended to limit the scope of the present invention. Other features of the present invention will become readily understood through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0031] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0032] Figure 1 1 is a schematic structural diagram of a signal processing system based on a planar architecture array provided in a first embodiment of the present invention;

[0033] Figure 2 This is a main framework diagram of a signal processing system based on a planar architecture array provided by the second embodiment of the present invention;

[0034] Figure 3 This is a schematic diagram of a signal processing state of a signal processing system based on a planar architecture array provided by the second embodiment of the present invention;

[0035] Figure 4 It is a structural diagram of a computer device provided in the second embodiment of the present invention. DETAILED DESCRIPTION

[0036] In order to enable those skilled in the art to better understand the solutions of the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0037] It should be noted that the terms "first", "second", etc. in the description and claims of the present invention and the above-mentioned drawings are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence. It should be understood that the numbers used in this way can be interchanged where appropriate, so that the embodiments of the present invention described herein can be implemented in an order other than those illustrated or described herein. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device that includes a series of steps or units is not necessarily limited to those steps or units clearly listed, but may include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0038] Example 1

[0039] Figure 1 This is a schematic diagram of the structure of a signal processing system based on a planar architecture array provided by the first embodiment of the present invention. The signal processing system based on a planar architecture array provided by this embodiment can be applied to the case where multiple sites in the sample to be analyzed are synchronously detected. Figure 1 As shown, the method includes: a planar array architecture function module 110, a recording intervention module 120 and an analysis module 130, wherein:

[0040] The planar array architecture functional module 110 includes an array support platform and a plurality of functional components, wherein the functional components are fixed on the array support platform;

[0041] The recording intervention module 120 includes a recording intervention component corresponding to the functional component, the recording intervention component is used to record the collected information, and the functional component is connected to the recording intervention component corresponding to the functional component;

[0042] The analysis module 130 is used to obtain the collected information recorded by the recording intervention component, and execute a corresponding analysis method to analyze the collected information, obtain analysis results, and display them.

[0043] In order to solve the technical problem of the single application scenario of the signal processing system in the prior art, in this embodiment, multiple functional components and recording intervention components corresponding to the multiple functional components are provided in the signal processing system, thereby realizing the application of corresponding functional components and information collection and analysis under different analysis requirements. Through the flexible combination of functional components and recording intervention components in the signal processing system, the analysis of multiple signal types and multiple analyte types is realized.

[0044] Optionally, after determining the signal processing and analysis requirements, the target functional components and target recording intervention modules corresponding to the signal processing and analysis requirements are determined, and the signal processing and analysis of the sample to be analyzed is realized by configuring the corresponding target functional components and target recording intervention components. The signal processing system provided in this embodiment is applicable to multifunctional array recording, fixed-point intervention and data analysis of samples to be analyzed (including in vivo or in vitro tissues or organs). Specifically, according to the size, thickness, shape, tissue layer structure and other factors of the sample to be analyzed, the corresponding components can be flexibly selected based on the concept of "movable type printing", and the functional components required for the study can be selectively inserted into the corresponding sites of the planar array architecture functional module. Furthermore, the number, density, position and depth of the target functional components can be adjusted, and the signal change characteristics on multiple consecutive two-dimensional planes are processed by three-dimensional superposition to comprehensively analyze and evaluate the state of the overall sample to be analyzed.

[0045] In this embodiment, analysis methods corresponding to different analysis requirements can be pre-set within the analysis module. After determining the analysis requirement, the analysis module determines the pre-set analysis method, uses the analysis method to analyze the collected information, and obtains and displays the analysis results. Alternatively, specific analysis methods can refer to analysis requirements and analysis methods in the prior art and are not limited here.

[0046] Optionally, based on the above scheme, the functional components are electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes and drug delivery tubes, and correspondingly, the recording intervention module is a multi-channel electrophysiological recording unit, a multi-channel electrochemical recording unit, a stimulator and a pressurized drug delivery device. Specifically, the functional components may include electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes or drug delivery tubes, and reference electrodes, wherein the electrophysiological electrodes are used to perform electrophysiological processing operations on the samples to be analyzed, the electrochemical electrodes are used to perform electrochemical processing operations on the samples to be analyzed, the electrical stimulation electrodes are used to perform electrical stimulation operations on the samples to be analyzed, and the drug delivery tubes are used to perform drug delivery operations on the samples to be analyzed; correspondingly, when the functional components include electrophysiological electrodes, the recording intervention module includes a multi-channel electrophysiological recording unit, and the multi-channel electrophysiological recording unit is connected to the electrophysiological electrodes, and the multi-channel electrophysiological recording unit is used to record the signals after the electrophysiological operations on the samples to be analyzed. Information; when the functional component includes an electrochemical electrode, the recording intervention module includes a multi-channel electrochemical recording unit, and the multi-channel electrochemical recording unit is connected to the electrochemical electrode, and the multi-channel electrochemical recording unit is used to record the information after the electrochemical operation on the sample to be analyzed; when the functional component includes an electrical stimulation electrode, the recording intervention module includes a stimulator, and the stimulator is connected to the electrical stimulation electrode, and the stimulator is used to determine the stimulation signal for electrically stimulating the sample to be analyzed; when the functional component includes a drug delivery tube, the recording intervention module includes a pressurized drug delivery device, and the pressurized drug delivery device is connected to the drug delivery tube, and the pressurized drug delivery device is used to record the drug delivery operation on the sample to be analyzed. Among them, the multi-channel electrophysiological recording unit and the multi-channel electrochemical recording unit can support 8-32 channels of signal input to realize multi-channel signal transmission.

[0047] An embodiment of the present invention provides a signal processing system based on a planar architecture array, including a planar array architecture functional module, a recording intervention module and an analysis module, wherein the planar array architecture functional module includes an array support platform and multiple functional components, and the functional components are fixed on the array support platform; the recording intervention module includes a recording intervention component corresponding to the functional component, and the recording intervention component is used to record the collected information, and the functional component is connected to the recording intervention component corresponding to the functional component; the analysis module is used to obtain the collected information recorded by the recording intervention component, and execute the corresponding analysis method to analyze the collected information, obtain the analysis results and display them. By setting multiple functional components and corresponding recording intervention modules, the signal processing system provided by this embodiment can flexibly combine the modules therein according to actual needs, thereby realizing the scenario requirements of multiple signal types and multiple analyte types.

[0048] In one embodiment of the present invention, the array support platform includes a planar matrix and a recording groove, wherein: the planar matrix includes multiple array sites for carrying the functional components; the recording groove is arranged below the array support platform for placing the sample to be analyzed.

[0049] The array sites of the planar matrix can carry functional components, that is, the functional components are placed on the array sites of the planar matrix, and the recording groove is set below the array support platform. When analyzing a sample to be analyzed, the sample to be analyzed can be placed in the recording groove first.

[0050] In addition to the above solution, the planar array architecture functional module further includes a micromanipulator fixedly connected to the planar matrix housing for controlling the movement of the planar matrix. To further enhance the flexibility of the signal processing system, a micromanipulator can be fixedly mounted on the planar matrix housing to control the movement of the planar matrix, thereby enabling more flexible component configuration. The micromanipulator can be manually controlled or automatically adjusted.

[0051] Based on the above scheme, the array support platform also includes a coordinate base plate, and the coordinate information on the coordinate base plate corresponds to the coordinate information of the array site on the plane matrix. The coordinate base plate can be set below the recording groove, and the coordinates on the coordinate base plate correspond to the coordinates on the plane matrix. After the sample to be analyzed is placed in the recording groove, the array site coordinate parameters of the sample to be analyzed can be obtained by comparing the sample to be analyzed with the coordinate base, and the appropriate functional components can be inserted and fixed in the corresponding coordinates on the array support platform. Before the experiment is recorded, the coordinate base plate can be pulled out, and pulling out the coordinate base plate has no effect on signal acquisition and analysis.

[0052] In one embodiment of the present invention, the signal processing system further includes a temperature-controlled perfusion module, which includes: a temperature controller, a water inlet pipe, a water outlet pipe, and a surge pump; the temperature controller is used to heat the perfusion fluid; the surge pump is used to control the heated perfusion fluid to flow through the water inlet pipe and the water outlet pipe through the recording tank.

[0053] Optionally, a temperature-controlled perfusion module can be used to achieve continuous, controllable heating of the sample to be analyzed. Specifically, a temperature controller heats the perfusate, which is then pumped through a surge pump into a recording tank via an inlet pipe and out of the recording tank via an outlet pipe, accurately controlling the perfusion temperature of the sample to be analyzed.

[0054] Optionally, the temperature controller includes: a heating tube, a temperature-sensitive probe and a temperature control host, wherein: the heating tube is connected to the water inlet pipe, the water inlet pipe, the water outlet pipe and the temperature-sensitive probe are all placed in the recording tank; the temperature-sensitive probe is used to detect the actual temperature of the perfusion fluid and provide feedback.

[0055] Optionally, appropriate temperature parameters can be set on the temperature control host, and the actual temperature of the perfusion fluid in the recording tank can be detected in real time with the help of a temperature-sensitive probe to adjust the heating intensity through feedback to achieve constant temperature perfusion of the sample to be analyzed.

[0056] In one embodiment of the present invention, the signal processing system also includes an imaging observation module, which includes: an operating platform, an imaging information acquisition component and an imaging unit, wherein: the operating platform is provided with an array of screw holes, and the imaging information acquisition component and the imaging component are fixed to the operating platform through corresponding screw holes; the imaging information acquisition component is used to obtain imaging information of the sample to be analyzed; and the imaging component is used to generate a target image based on the imaging information for display.

[0057] Based on the above scheme, an imaging observation module can also be provided to implement imaging observation of the sample to be analyzed. Generally speaking, imaging observation includes two parts: imaging and display. In this embodiment, imaging information is collected by an imaging information acquisition component, and images are generated and displayed by an imaging component. The image generation program can be written into a chip, and the chip can be placed in a signal processing system. Images can also be generated using a pre-written image generation program. Alternatively, images can be generated and displayed using an independent computer device, without limitation.

[0058] To enrich imaging methods, the imaging information acquisition component includes a camera and a microscope. That is, imaging information can be acquired using a camera and / or a microscope. Optionally, the microscope can be an upright microscope, a stereoscope, or an inverted microscope, depending on the sample to be analyzed, without limitation.

[0059] In one embodiment of the present invention, the executing of the corresponding analysis method to analyze the collected information, obtain the analysis results and display them, including: executing the corresponding analysis method to analyze the collected information to obtain signal evaluation parameters; determining the display information in the form of a heat map corresponding to the signal evaluation parameters, and displaying based on the display information.

[0060] Optionally, the analysis module can be used to present parameters such as signal intensity and frequency from electrophysiological and electrochemical data as heatmaps over the corresponding imaging data in the sample, allowing for a display based on the heatmap data. Furthermore, continuous integration results can be overlaid in three dimensions, enabling a more comprehensive assessment and analysis of the physiological and / or pathological characteristics of the entire sample.

[0061] Example 2

[0062] Figure 2 This is a main framework diagram of a signal processing system based on a planar architecture array provided by the second embodiment of the present invention. This embodiment provides a preferred embodiment based on the above embodiment.

[0063] It should be noted that the system provided in this embodiment is suitable for multifunctional array recording, fixed-point intervention and data analysis of in vivo or ex vivo tissue or organ samples, can support multiple signal recording modes and intervention modes, can meet the research needs of various paradigms and scenarios, and can be used to evaluate the overall physiological and / or pathological characteristics of specific lesions in clinical practice, so as to have a more comprehensive and in-depth understanding of their spatial characteristics, and can perform targeted interventions, thereby understanding the spatial connections between the various components in the sample, as well as the influence characteristics of the tissue on electrical stimulation, drugs, etc., which helps to formulate personalized and precise treatment intervention plans.

[0064] like Figure 2 As shown, the signal processing system based on the planar architecture array includes a planar array architecture function module, a temperature control perfusion module, an imaging observation module, a recording and intervention module, and an analysis module.

[0065] Optionally, the planar array architecture functional module includes an array support platform, functional components, a coordinate baseplate, a recording tank, a micromanipulator, and multifunctional leads. The array support platform includes a planar matrix and a recording tank; the functional components include electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes, or a drug delivery tube, as well as a reference electrode; the micromanipulator is fixedly connected to the planar matrix housing and can be used to move the planar matrix; the coordinate baseplate is located below the recording tank; and the multifunctional leads are signal cables or catheters inserted into the planar matrix's electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes, or drug delivery tubes.

[0066] In one implementation, the planar matrix above the array support platform can contain 16-256 array sites, with an aperture of 10-500 μm and a spacing of 50-1000 μm. The planar matrix is ​​marked with site coordinates, which can be composed of letters, numbers, symbols, etc. Functional components such as electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes, or drug delivery tubes can be inserted and fixed. The planar matrix material can be acrylic sheet, and the outer shell can be plastic or 3D-printed materials. Below the array support platform is a recording tank with a circular or square bottom shape and a diameter or side length of 1-3 cm. The material is preferably glass, and the outer shell can be plastic or 3D-printed materials. The electrochemical electrode and the electrophysiological electrode can share a reference electrode made of silver / silver chloride.

[0067] In one implementation, the coordinates on the coordinate baseplate correspond to the coordinates on the planar matrix. After the tissue or organ sample to be recorded is placed in the recording slot, the array site coordinate parameters of the tissue to be detected and / or intervened are obtained by comparing the sample with the coordinate baseplate. Appropriate functional components are then inserted and fixed at the corresponding coordinates on the array support platform. Before experimental recording, the coordinate baseplate can be removed. By setting the coordinates on the coordinate baseplate, components can be accurately inserted during operation, thereby accurately acquiring and analyzing signals.

[0068] Optionally, the recording and intervention module includes a multi-channel electrochemical recording device, a multi-channel electrophysiological recording device, a stimulator, and a pressurized drug delivery device. The multi-channel electrochemical recording device is connected to the electrochemical electrodes in the planar array architecture functional module, and can support 8-32 channels of signal input; the multi-channel electrophysiological recording device is connected to the electrophysiological electrodes in the planar array architecture functional module, and can support 8-32 channels of signal input; the stimulator is connected to the electrical stimulation electrodes in the planar array architecture functional module; and the pressurized drug delivery device is connected to the drug delivery tube in the planar array architecture functional module.

[0069] The optional temperature-controlled perfusion module includes a temperature controller, an inlet pipe, an outlet pipe, and a surge pump. The temperature controller contains a heating tube, a temperature-sensitive probe, and a temperature controller. The inlet pipe, outlet pipe, and temperature-sensitive probe are all placed in the recording tank; the heating tube is connected to the inlet pipe. By setting appropriate temperature parameters on the temperature controller and using the temperature-sensitive probe to monitor the actual temperature of the perfusate in the recording tank in real time, feedback is provided to adjust the heating intensity. The perfusate heated by the temperature controller flows through the inlet and outlet pipes and into the recording tank under the action of the surge pump, providing continuous and controllable heating of the sample.

[0070] Optionally, the imaging observation module includes a microscope, a camera, an operating platform, and digital imaging. The microscope can be an upright microscope, a stereoscope, or an inverted microscope depending on the in vivo or in vitro tissue or organ sample; the imaging information of the sample is transmitted to the computer for digital imaging through the camera. There are array-type screw holes on the operating platform, and the planar array architecture functional module can be fixed on it by screws. Figure 2 In the present invention, digital imaging is realized by an independent computer device, and imaging software can be installed in the computer device to generate images through the imaging software, and the generated images are displayed to realize imaging observation of the sample to be analyzed.

[0071] Figure 3 1 is a schematic diagram of a signal processing state of a signal processing system based on a planar architecture array provided in a second embodiment of the present invention. Figure 3 In the figure, 101 is the support platform, 102-1 is the electrophysiological electrode, 102-2 is the electrochemical electrode, 102-3 is the electrical stimulation electrode, 102-4 is the drug delivery tube, 102-5 is the reference electrode, 103 is the coordinate base plate, 104 is the recording tank, 201-1 is the heating tube, 201-2 is the temperature sensitive probe, 202 is the water inlet pipe, and 203 is the water outlet pipe. Figure 3 As shown, the electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes, drug administration tubes, and reference electrodes are located at array sites in the support platform, and the heating tube, temperature-sensitive probe, water inlet tube, and water outlet tube are in the recording tank.

[0072] Optionally, the analysis module includes a software system for collecting and analyzing imaging data, electrophysiological data, and electrochemical data. This module can be used to present parameters such as signal intensity and frequency in electrophysiological data and electrochemical data in the form of a heat map on the corresponding imaging data in the sample, and can perform a three-dimensional superposition of continuous integration results, thereby performing a more comprehensive evaluation and analysis of the physiological and / or pathological characteristics of the entire sample. It is understandable that the analysis module can be configured in a chip and set within the system, or it can be an independent computer device that is connected to the system for communication. Figure 2 In the analysis module, the analysis module is an independent computer device, which is installed with data acquisition and analysis software. The data acquisition and analysis software in the computer device is used to analyze the collected data to realize the analysis of the collected data and the display of the analysis results.

[0073] Optional, Figure 2The computer device in the present invention may be a digital computer in various forms, such as a laptop computer, a desktop computer, a workstation, a personal digital assistant, a server, a blade server, a mainframe computer, and other suitable computers. The computer device may also be a mobile device in various forms, such as a personal digital assistant, a cellular phone, a smart phone, a wearable device (such as a helmet, glasses, a watch, etc.) and other similar computing devices.

[0074] Figure 4 This is a schematic diagram of the structure of a computer device provided by the second embodiment of the present invention. Figure 4 As shown, computer device 10 includes at least one processor 11 and memory, such as read-only memory (ROM) 12 and random access memory (RAM) 13, communicatively connected to at least one processor 11. The memory stores computer programs executable by the at least one processor. Processor 11 can perform various appropriate actions and processes based on the computer programs stored in ROM 12 or loaded from storage unit 18 into RAM 13. RAM 13 may also store various programs and data required for the operation of computer device 10. Processor 11, ROM 12, and RAM 13 are interconnected via bus 14. An input / output (I / O) interface 15 is also connected to bus 14. Multiple components in computer device 10 are connected to I / O interface 15, including: an input unit 16, such as a keyboard and mouse; an output unit 17, such as various types of displays and speakers; a storage unit 18, such as a magnetic disk and optical disk; and a communication unit 19, such as a network card, a modem, or a wireless communication transceiver. The communication unit 19 allows the computer device 10 to exchange information / data with other devices via a computer network such as the Internet and / or various telecommunication networks. The processor 11 can be a variety of general-purpose and / or specialized processing components with processing and computing capabilities. Some examples of the processor 11 include, but are not limited to, a central processing unit (CPU), a graphics processing unit (GPU), various dedicated artificial intelligence (AI) computing chips, various processors running machine learning model algorithms, a digital signal processor (DSP), and any appropriate processor, controller, microcontroller, etc. The processor 11 performs the various methods and processes described above.

[0075] In some embodiments, the imaging method and / or the data analysis method may be implemented as a computer program tangibly embodied in a computer-readable storage medium, such as storage unit 18. In some embodiments, part or all of the computer program may be loaded and / or installed onto computer device 10 via ROM 12 and / or communication unit 19. When the computer program is loaded into RAM 13 and executed by processor 11, one or more steps of the method described above may be performed. Alternatively, in other embodiments, processor 11 may be configured to perform the above-described method in any other suitable manner (e.g., via firmware).

[0076] The system provided by the embodiments of the present invention can instantly adjust the number, density, position, and depth of functional components based on factors such as the size, thickness, shape, and tissue layer structure of the in vivo or ex vivo tissue or organ sample being studied, effectively reducing the number of unnecessary and ineffective recording electrodes and lowering research costs. It has flexible combination characteristics and can support the recording of electrophysiological and electrochemical signals, thus coping with recording scenarios of various signal types and multiple analyte types. Localized precise targeted intervention can be performed by setting functional components such as electrical stimulation or drug administration next to the recording site, or by removing the electrophysiological or electrochemical electrodes in the recording site and replacing them with intervention functional components, thus adapting to a variety of different application paradigms. The analysis module in the system focuses on three-dimensionally superimposing the signal change characteristics on multiple continuous two-dimensional planes to comprehensively analyze and evaluate the physiological and / or pathological status of the entire tissue or organ. The components and accessories are independent of each other and can be reused multiple times, which can effectively reduce research costs.

[0077] It should be understood that the various forms of the processes shown above can be used to reorder, add, or delete steps. For example, the steps described in the present invention can be performed in parallel, sequentially, or in a different order, as long as the desired results of the technical solution of the present invention can be achieved. This is not limited herein.

[0078] The above specific embodiments do not limit the scope of protection of the present invention. Those skilled in the art will appreciate that various modifications, combinations, sub-combinations, and substitutions may be made based on design requirements and other factors. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention are intended to be included within the scope of protection of the present invention.

Claims

1. A signal processing system based on a planar architecture array, characterized in that: It includes a planar array architecture functional module, a recording intervention module, and an analysis module, among which: The planar array architecture functional module includes an array support platform and a plurality of functional components, wherein the functional components are fixed on the array support platform; The recording intervention module includes a recording intervention component corresponding to the functional component, the recording intervention component is used to record the collected information, and the functional component is connected to the recording intervention component corresponding to the functional component; The analysis module is used to obtain the collected information recorded by the recording intervention component, and execute a corresponding analysis method to analyze the collected information, obtain analysis results and display them; The array support platform includes a planar matrix and a recording slot, wherein: The planar matrix includes a plurality of array sites for carrying the functional components; The recording tank is provided below the array support platform and is used for placing samples to be analyzed; The planar array architecture functional module further includes a micromanipulator, which is fixedly connected to the outer shell of the planar matrix and is used to control the movement of the planar matrix; The array support platform further includes a coordinate base plate, and the coordinate information on the coordinate base plate corresponds to the coordinate information of the array sites on the plane matrix, wherein the coordinate base plate is arranged below the recording groove.

2. The system according to claim 1, wherein: The functional components are electrophysiological electrodes, electrochemical electrodes, electrical stimulation electrodes and drug delivery tubes. Correspondingly, the recording intervention module is a multi-channel electrophysiological recording unit, a multi-channel electrochemical recording unit, a stimulator and a pressurized drug delivery device.

3. The system according to claim 1, wherein: The signal processing system further comprises a temperature-controlled perfusion module, which comprises: a temperature controller, a water inlet pipe, a water outlet pipe and a surge pump; The temperature controller is used to heat the perfusion fluid; The surge pump is used to control the heated perfusion fluid to flow through the recording tank via the water inlet pipe and the water outlet pipe.

4. The system according to claim 3, characterized in that The temperature controller includes: a heating tube, a temperature sensitive probe and a temperature control host, wherein: The heating pipe is connected to the water inlet pipe, and the water inlet pipe, the water outlet pipe and the temperature sensitive probe are all placed in the recording tank; The temperature-sensitive probe is used to detect the actual temperature of the perfusion fluid and provide feedback.

5. The system according to claim 1, wherein: The signal processing system further includes an imaging observation module, which includes: an operating platform, an imaging information acquisition component and an imaging unit, wherein: The operating platform is provided with an array of screw holes, and the imaging information acquisition component and the imaging component are fixed to the operating platform through corresponding screw holes; The imaging information acquisition component is used to obtain imaging information of the sample to be analyzed; The imaging component is used to generate a target image based on the imaging information for display.

6. The system according to claim 5, characterized in that The imaging information acquisition component includes a camera and a microscope.

7. The system according to claim 1, wherein: The executing of the corresponding analysis method to analyze the collected information, obtain and display the analysis results, includes: Executing a corresponding analysis method to analyze the collected information to obtain signal evaluation parameters; Determine display information in the form of a heat map corresponding to the signal evaluation parameter, and perform display based on the display information.

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