Anti-blue light contact lenses and manufacturing materials and methods therefor

Abstract

A kind of anti-blue light, anti-UV spectacle lens material, contact lens and its process. The copolymer mixture is composed of linear silicon-containing prepolymer monomer, hydrophilic monomer, UV absorber and silver ion-containing solvent. Through blue light initiation and completion of free radical chain lock polymerization and cross-linking reaction, a body can be formed after curing process. The invention does not need to add additional reducing agent and dispersant, and can reduce silver ions to nano metal silver particles through in-situ redox reaction. In this way, the silver / silicon composite nanoparticles in the silicon-containing spectacle lens material can be uniformly distributed without affecting the photopolymerization process, and very low silver ion concentration can achieve the effect of anti-blue light. Anti-UV reactive monomers can be further copolymerized to make anti-blue light, anti-UV high oxygen permeable silicone hydrogel contact lenses.

Description

TECHNICAL FIELD

[0001] The present invention relates to the manufacturing method, material and finished product of the blue light resistant contact lens. BACKGROUND

[0002] Since the invention of contact lens in early 1950s, it has been commercialized for 70 years. The first contact lens was made of hard material (e.g. PMMA). Since the material is hard, and the oxygen permeability and hydrophilicity of the lens are not good, the wearing time of the lens is short, and the lens will cause obvious foreign body sensation. In the 1970s, the invention of soft contact lens was a great progress. The soft contact lens was made of HEMA (2-hydroxyethyl methacrylate) based hydrogel material. Since the material has high water absorption, and the hydrated material has soft and high water content, the wearing comfort is greatly improved. However, the oxygen permeability is still low, and the lens can only be worn for 8 to 12 hours per day. After long time wearing, corneal anoxia edema and neovascularization often occur. In the early 1980s, there were high oxygen permeability hard contact lens products. The oxygen permeability of the lens is very high. However, since the material is hard, the foreign body sensation caused by wearing the lens on the eyeball cannot be improved, and the lens cannot be widely accepted by consumers. As described above, there is a demand for contact lens with high oxygen permeability, high comfort and long wearing time. Through continuous improvement of the contact lens industry, the development of high oxygen permeability soft silicone hydrogel has become a mainstream.

[0003] With the popularization and use of liquid crystal screen TV, tablet computer and smart phone, the problem of blue light hazard is gradually paid attention to. It is generally believed that blue light can increase the risk of macular degeneration and retinal degeneration. The visible light wavelength of both eyes is 380-780 nm, and the light wavelength that increases eye glare and fatigue is short-wave blue light of 381-460 nm. Excessive blue light can cause eye damage. Blue light can penetrate the lens and vitreous body to reach the macula and retina, causing light damage to the eye. In addition, when blue light enters the eye, it produces a large number of free radicals, which damage the unsaturated fatty acids of the retina. In the early stage of excessive blue light damage, the eye is more sensitive to light, with symptoms such as stinging and photophobia. At this time, if the excessive blue light damage is not improved in real time, the macula will be inflamed and edematous. Once the macular area forms a drusen, when the drusen ruptures, it will cause hemorrhage, resulting in central visual impairment. In short, excessive blue light can cause cataracts and even macular degeneration. Blue light can hinder sleep, as it will delay or stop the secretion of melatonin produced by the brain, making it more difficult to enter a sleep state. Generally, the human lens can filter 30%-50% of the blue light in the light, and the human body also needs a certain amount of blue light to maintain visual and psychological operation. Moderate blue light makes objects and fields of view brighter, making people feel happier. On the contrary, if too much blue light is filtered, it is easy to make people feel depressed, anxious, and even have a melancholy mood. A filter value of 30% can achieve the effect of filtering blue light. In view of the foregoing problems, more and more people start to wear anti-blue light glasses to reduce the harm of blue light (blue-violet light) to the eyes. At present, most anti-blue light frame glasses add yellow dye or surface coating to the lens to change the color of the lens, so that the lens can filter out blue light. However, most contact lenses cannot use the above-mentioned method, especially for silicone hydrogel contact lenses, which has many obstacles and complexities. Therefore, how to provide users with better anti-blue light contact lens products has become an important issue that the present invention wants to explore.

[0004] The anti-blue light contact lens commonly known in the market is disclosed in Taiwan Patent No. M487455 "Color contact lens with blue light filtering and anti-UV function", which is composed of upper, middle and lower lenses, and uses a blue light filtering coating agent in the upper lens to reduce the penetration of blue light through the contact lens to the eye. The blue light filtering coating agent is not currently legally added to the contact lens by the US FDA, which raises concerns about eye damage, and in addition to time, labor and cost, there is no mass production efficiency.

[0005] Taiwanese Patent No. I554803 discloses a method for manufacturing anti-blue light contact lenses with simplified process and consistent production. One or more yellow, orange, red, green, etc. dyes are adjusted according to the dye color and addition ratio, or a blue light absorber is added to the contact lens hydrogel or silicon hydrogel monomer, then the process of mold casting or spin molding is performed, and after the dry piece is cured and formed, it is put into a hydration tank for color fixation and hydration extraction to complete the anti-blue light contact lens product. However, this invention is not suitable for high-concentration dyes, as it also blocks the UV-visible light starting reaction (wavelength 380-400 nm) and cannot polymerize to form lenses.

[0006] Taiwanese Patent No. I725719 discloses another anti-blue light eyeglass lens material, eyeglass lens and its process. The eyeglass lens material can be used to manufacture the required eyeglass lens, which at least includes a mixture composed of silver / silicon oxide composite nanoparticles and at least one polymer monomer. Each polymer monomer can form a body after a material curing process. The invention is analyzed at the front end, which adds a reducing agent solution to reduce it into nano silver first, then concentrates it after centrifugation and dissolves it in the reaction monomer, and finally irradiates the mixture with ultraviolet light (UV). The polymer monomer and photoinitiator are crosslinked by ultraviolet light (UV) to form the body mixed with the silver / silicon oxide composite nanoparticles. The above process is extremely complicated, and the formed nano silver composite cannot avoid re-aggregation after centrifugal concentration, which affects its dispersibility. Therefore, it will affect the photopolymerization reactivity to some extent, causing changes in the lens body structure or specifications.

[0007] Currently, the public has little understanding of nanometer silver, because of lack of understanding, it is easy to produce some false rumors or misunderstanding, which is one of the most easily misreported misunderstandings. Nanometer silver is not banned in the EU and the United States. There are many cosmetic and daily use products with nanometer silver on the market in the United States and the EU. In addition, nanometer silver aqueous solution will not penetrate the dermis and will not penetrate the nasal mucosa epithelial cell layer under normal use. Nanometer silver aqueous solution is not only certified, but also will not cause irritation and allergic reactions to the skin and eyes. Due to the excellent antibacterial activity of nanometer silver, it is often used as an industrial raw material and applied to daily necessities and medical care products, including anti-pollution layers for washing machine surfaces, pure water purification, toys, surgical instruments, etc. In addition, its special optical properties are also gradually being widely used in optical materials. The principle is to use silver nanoparticles to have a surface plasmon resonance (SPR) effect on light waves (ultraviolet, visible, and near-infrared ranges). Because silver has many free electrons, these electrons are easily moved by external electromagnetic fields and gradually form a shielding effect from the outside to the inside, so that the internal electrons cannot feel the changes in the external electromagnetic field. However, when gold or silver particles are small enough (about less than 200 nm), all free electrons in the entire metal particle move collectively, which causes great absorption and scattering of incident light waves. This phenomenon is called surface plasmon resonance effect. The yellow solution of synthesized silver-containing nanoparticles is because the surface plasmon resonance causes the silver nanoparticles to absorb and scatter 420 nm blue light, so that when white light is transmitted through the solution, only the main light waves (red and green light) penetrate, so the human vision presents a yellow effect. Therefore, anti-blue light contact lenses can be developed by using its blue light filtering properties. SUMMARY

[0008] The present application provides a method for manufacturing anti-blue light contact lenses, comprising the steps of synthesizing a polysiloxane prepolymer, wherein the polysiloxane prepolymer contains polyethylene glycol; dissolving a silver ion compound in a non-aqueous solvent to prepare a silver ion solution; mixing the silver ion solution with the polysiloxane prepolymer to uniformly distribute silver ions in the silver ion solution in the polysiloxane prepolymer; adding a hydrophilic monomer and a photoinitiator to the polysiloxane prepolymer to form a silicone hydrogel composition; and irradiating the silicone hydrogel composition with blue light to simultaneously perform a crosslinking curing reaction and a silver ion reduction reaction, thereby forming a silicone hydrogel lens with anti-blue light nanometer silver.

[0009] The silicone hydrogel composition can further include 10 to 20 wt% of a diluent.

[0010] The biphilic silicone pre-polymer can be synthesized by the following method: a dihydroxyl polydimethylsiloxane compound and an isocyanate compound are used as raw materials, and a diluent is added to react at a medium temperature to obtain a first product; the first product is added to a hydrophilic chain extender, and a terminal hydroxyl group reaction and a chain extension reaction are sequentially performed to obtain a second product; the second product and an acrylate compound are continuously reacted at room temperature for at least 12 hours to obtain a biphilic silicone pre-polymer; and the hydrophilic chain extender is mainly a polyol series, which can include ethylene glycol, propylene glycol, 1,4-butanediol, polyethylene glycol, polypropylene glycol, polypropylene glycol diglycidyl ether, etc.

[0011] The silicone hydrogel composition can further include 10 to 20 wt% of a diluent.

[0012] The silicone-containing monomer can be 3-methacryloxypropyl tris(trimethylsiloxy)silane (TRIS), 3-acryloxypropyl tri(trimethylsiloxy)silane, 3-acrylamidopropyl tris(trimethylsiloxy)silane, 3-methacrylamidopropyl tris(trimethylsiloxy)silane, (3-methacryloxy-2-hydroxypropoxy)propyl bis(trimethylsiloxy)methylsilane, Si GMA, a monofunctional polydimethylsiloxane (mPDMS) having a number average molecular weight of 657 to 1500, or a combination thereof.

[0013] The hydrophilic monomer can be 2-hydroxyethyl methacrylate (HEMA); N,N-dimethyl acrylamide (DMA), N,N-diethyl acrylamide (DEA), N-vinyl pyrrolidone (NVP), glycerol methacrylate (GMA), polyethylene glycol methacrylate mono methyl ether with a molecular weight of 400, or a combination thereof.

[0014] When mixing the above-mentioned silicone hydrogel composition, an ultraviolet blocking monomer can also be added at the same time, wherein the content of the ultraviolet blocking monomer is 0.1-1.5 wt%. The ultraviolet blocking monomer can be a monomer having benzotriazole.

[0015] The present application also provides a material for manufacturing a blue light resistant spectacle lens, comprising the above-mentioned silicone hydrogel composition.

[0016] The present application also provides a blue light resistant spectacle lens manufactured by the above-mentioned method.

[0017] Other features and advantages of the present application will be set forth in the description that follows, and in part will become apparent to those skilled in the art upon examination of the following or can be learned by practice of the present application. The objects and other advantages of the present application can be realized and attained by the structure particularly pointed out in the description and claims hereof as well as the appended drawings. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings needed to be used in the embodiments or the prior art description. Obviously, the drawings described below are some embodiments of the present application, and for those skilled in the art, other drawings can also be obtained from these drawings without creative labor; in the following description, the positional relationship described in the drawings is the direction of the components drawn in the drawings as the reference, unless otherwise specified.

[0019] Figure 1 is a comparison chart of the changes of the optical properties of the lenses produced by the embodiments of the present application. DETAILED DESCRIPTION

[0020] In order to make the objects, technical solutions and advantages of the embodiments of the present application clearer, the following will clearly and completely describe the technical solutions in the embodiments of the present application with reference to the drawings in the embodiments of the present application. Obviously, the described embodiments are only some but not all of the embodiments of the present application; as long as there is no conflict, the technical features in the different embodiments of the present application can be combined with each other; on the basis of the embodiments of the present application, all other embodiments obtained by a person of ordinary skill in the art without creative work fall within the protection scope of the present application.

[0021] In the description of the present application, it should be understood that the orientation or positional relationship indicated by the terms "center", "transverse", "upper", "lower", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer" and the like is based on the orientation or positional relationship shown in the drawings, and is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or component referred to must have a particular orientation or be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the present application. In addition, the terms "first", "second" are only for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of the technical features indicated. Therefore, the features defined as "first", "second" can explicitly or implicitly include one or more of the features. In the description of the present application, unless otherwise specified, the meaning of "a plurality of" is two or more. In addition, the term "comprising" and any variation thereof means "at least including".

[0022] In the description of the present application, it should be noted that, unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connection" should be understood broadly, for example, it can be fixed connection, or detachable connection, or integrally formed connection; it can be mechanical connection, or electrical connection; it can be direct connection, or indirect connection through an intermediate medium, or internal communication of two components. For those skilled in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0023] The terms used herein are only used to describe specific embodiments and are not intended to limit exemplary embodiments. Unless the context clearly indicates otherwise, as used herein, the singular form "a", "an" and "the" is also intended to include a plurality. It should also be understood that the terms "including" and / or "comprising" as used herein specify the presence of stated features, integers, steps, operations, units and / or components, and do not exclude the presence or addition of one or more other features, integers, steps, operations, units, components and / or combinations thereof.

[0024] The present invention provides an anti-blue light spectacle lens material, which can be used to manufacture a spectacle lens, wherein the spectacle lens material comprises at least a mixture of a polysiloxane prepolymer, a silver ion solution and at least one hydrophilic monomer, the mixture is subjected to a material curing process to form a body, and the body contains silver / silicon composite nanoparticles, when the particle size of silver is 1 nanometer (nm) to 100 nanometers, it can absorb blue light with a wavelength of 400 nanometers to 500 nanometers, therefore, by means of silver / silicon composite nanoparticles, the blue light with greater energy in the visible light penetrating through the spectacle lens can be absorbed to achieve the purpose of anti-blue light, in this way, the polysiloxane prepolymer can be used as a nano-silver protective agent or dispersant, and can also be used as a crosslinking agent for body polymerization. The polyethylene glycol (PEG) in the polysiloxane prepolymer stabilizes the nanoparticles through the structure, and the central bonding ability is strong and not easy to dissociate into ions. The reduction of silver ions by blue light can form uniformly distributed nano-silver particles in the body without the need for additional reducing agents, most importantly, this process is in-situ and does not affect the degree of photopolymerization, so the lens strength and integrity can be maintained to achieve the comfortable wearing specifications of contact lenses. This is different from other anti-blue light contact lens manufacturing principles, which first reduce metal nanoparticles and then add them to the reaction monomer, so the photopolymerization reaction will be greatly disturbed. Because the photo-initiation wavelength of the ultraviolet light is between 360-420 nm, the metal nanoparticles will absorb or scatter this wavelength, causing insufficient initiation energy and uniformity, greatly affecting the integrity and strength of the lens body, that is, the lens will be distorted and deformed, affecting the effectiveness of vision correction and the comfort and safety of wearing.

[0025] <Synthesis of polysiloxane prepolymer>

[0026] The present invention provides a method for preparing a dual-silicon-containing prepolymer, which is obtained by isocyanic acid reaction of a polydimethylsiloxane compound, followed by end-capping with a hydroxyl monomer. The method comprises the following steps: isocyanic acid reaction: using a dihydroxyl polydimethylsiloxane compound and an isocyanic acid compound as raw materials, adding a diluent, and reacting at a moderate temperature to obtain a first product; adding a hydrophilic chain extender to the first product, sequentially performing terminal hydroxyl group reaction and chain extension reaction to obtain a second product; and continuously reacting the second product and an acrylate compound at room temperature for at least 12 hours to obtain a dual-silicon-containing prepolymer as a third product. The hydrophilic chain extender is mainly a polyol series including ethylene glycol, propylene glycol, 1,4-butanediol, polyethylene glycol, polypropylene glycol, and polypropylene glycol diglycidyl ether.

[0027] A detailed example is as follows: 50 g of dimethylpolysiloxane containing two terminal hydroxyl groups (trade name: KF-6001, available from Shin-Etsu Chemical Co., Ltd.) was added with 10 g of isofurone diisocyanate and 0.02 g of dibutyltin dilaurate under a nitrogen atmosphere at room temperature, and the reaction was allowed to proceed for 12 hours. Then, 30 g of polyethylene glycol (weight average molecular weight: 600), 100 g of tetrahydrofuran, and 0.02 g of dibutyltin dilaurate were added, and the reaction was allowed to proceed for 24 hours. The reaction was completed when the characteristic peak of -NCO at around 2250 cm-1 disappeared in the infrared absorption spectrum. Then, 10 g of isofurone diisocyanate and 0.02 g of dibutyltin dilaurate were added under a nitrogen atmosphere at room temperature, and the reaction was allowed to proceed for 24 hours. Then, 12 g of 2-methyl-2-propenoic acid 2,3-dihydroxypropyl ester and 0.02 g of dibutyltin dilaurate were added, and the reaction was allowed to proceed at 60°C for 24 hours. The reaction was completed when the characteristic peak of -NCO at around 2250 cm-1 disappeared in the infrared absorption spectrum. A polysiloxane prepolymer having a dimethylpolysiloxane main structure was obtained, and the weight average molecular weight thereof was 11,000 to 13,000 (determined by GPC).

[0028] <Hydrophilic copolymer composition>

[0029] The present application provides a hydrophilic copolymer composition comprising a polysiloxane prepolymer, a monofunctional silicone acrylate, and a hydrophilic monomer. The hydrophilic monomer can be, but is not limited to, N,N-dimethylacrylamide (abbreviated as DMA, available from TCI Corporation), N-vinylpyrrolidone (abbreviated as NVP, available from ALDRICH Corporation), 2-hydroxyethyl methacrylate (abbreviated as HEMA, available from TCI Corporation), or ethylene glycol dimethacrylate (abbreviated as EGDMA, available from BASF Corporation). In addition, the hydrophilic monomer can be used alone or two or more (including two) types thereof can be used simultaneously.

[0030] The aforementioned hydrophilic copolymer composition can further comprise a diluent and a photoinitiator. The diluent can increase the mutual solubility, and the content of the diluent can be 0 to 25% by weight. The diluent can be, but is not limited to, isopropyl alcohol (abbreviated as IPA). In addition, the diluent can be used alone or two or more (including two) types thereof can be used simultaneously. The photoinitiator is advantageous for UV photocuring, and the content of the photoinitiator can be 0.1% to 2% by weight. The photoinitiator can be, but is not limited to, CibaC IRGACURE C 1173, abbreviated as I-1173, and CibaC IRGACURE C 819, abbreviated as I-819. In addition, the photoinitiator can be used alone or two or more (including two) types thereof can be used simultaneously. The aforementioned hydrophilic copolymer composition can optionally further comprise other additives to meet actual needs, and the additives that can be used include, but are not limited to, anti-UV absorbers, leveling agents, and the like.

[0031] <Silver ion solution>

[0032] Inorganic silver salts are the most common silver ion compounds, and common ones are silver nitrate, silver acetate and silver thiosulfate. Silver ion compounds are dissolved in non-aqueous solvents, which are usually methanol, ethanol, propanol (molecular formula C3H7OH), isopropanol (molecular formula C3H8O), butanol (molecular formula C4H9OH) or ethylene glycol, etc.

[0033] The present application is a kind of anti-blue light glasses lens material, glasses lens and its process, in an embodiment, the glasses lens can be used as contact lenses or general glasses lens.

[0034] In the embodiments of the present application, the silicon-containing monomers other than the polysiloxane prepolymer can be selected from the group consisting of 3-methacryloxypropyl tris(tirmethylsiloxy)silane (TRIS), 3-acryloxypropyl tri(trimethylsiloxy)silane, 3-acrylamidopropyl tris(trimethylsiloxy)silane, 3-methacrylamidopropyl tris(trimethylsiloxy)silane, (3-methacryloxy-2-hydroxypropoxy)propyl bis(trimethylsiloxy)methylsilane, SiGMA, monofunctional polydimethylsiloxane (mPDMS) having a number average molecular weight of 657 to 1500, and combinations thereof;

[0035] In the embodiments of the present application, the first hydrophilic monomer is selected from the group consisting of 2-hydroxyethyl methacrylate (HEMA), N,N-dimethyl acrylamide (DMA), N,N-diethyl acrylamide (DEA), N-vinylpyrrolidone (NVP), glycerol methacrylate (GMA), polyethylene glycol methacrylate mono methyl ether with a molecular weight of 400, and combinations thereof.

[0036] According to the embodiments of the present application, the derivative silicon-containing monomer comprises 30-80 wt% of polysiloxane prepolymer, 10-50 wt% of repeating units of the hydrophilic monomer, 10-20 wt% of the diluent, and 0.1-1.5 wt% of the UV blocking monomer having benzotriazole. According to the embodiments of the present application, the photoinitiator accounts for 0.1-2 wt% of the total weight, and the silver ion compound accounts for 10-200 ppm of the total weight.

[0037] According to one of the embodiments of the present application, a method for preparing a blue light resistant contact lens comprising nano silver and a silicone hydrogel is provided.

[0038] First, the silver ion compound is added to the diluent and stirred for about 0.5-1.5 hours, and the temperature of the silver ion solution is maintained at room temperature (20-40°C) to completely dissolve the silver ion compound. The polysiloxane prepolymer is first added and stirred for about 0.5-1.5 hours, and then the silicon-containing monomer, the hydrophilic monomer, the photoinitiator, and the UV blocking monomer are added together and stirred for about 0.5-1.5 hours to obtain the silicone hydrogel composition of the present application. In one aspect of the present application, a method for manufacturing the silicone hydrogel lens is provided. The silicone hydrogel composition of any of the embodiments or examples is injected into a mold for manufacturing the lens, and the silicone hydrogel composition in the mold is subjected to photocuring for 30-60 minutes to perform a crosslinking and curing reaction, thereby forming a silicone hydrogel lens. The silicone hydrogel lens is extracted with a liquid containing water to remove silicone polymers that do not undergo the crosslinking and curing reaction, and the silicone hydrogel lens is subjected to high-temperature and high-pressure sterilization in a phosphate or borate saline buffer solution having a pH of 7.1-7.5.

[0039] In the following examples, the silicone hydrogel lenses manufactured by the above manufacturing method were tested for various parameters according to international standard ISO 18369, including water content, optical refractive index, visible light transmittance, blue light transmittance and oxygen permeability, in addition to lens strength and elastic modulus, etc. All commercially available silicone hydrogel lenses have the following characteristics: visible light transmittance greater than 89%, water content of 24 to 74%, oxygen permeability of 45 to 140 DK, tensile strength greater than 1 MPa, elastic modulus between 0.4 and 1.2, and elongation greater than 50%.

[0040] According to the above embodiments, the following examples are provided

[0041] Example 1

[0042] 0.001, 0.005, 0.01 and 0.02 g of silver nitrate (designated as SHy, SAg10, SAg50, SAg100 and SAg200, respectively) were dissolved in 20 g of IPA at room temperature and stirred for 1 hour. Then, 50 g of siloxane prepolymer was added and stirred at room temperature for 1 hour. Next, 10 g of TRIS / 30 g of DMA was added, followed by 1 g of 2-(2'-hydroxy-5-methacrylyloxyethylphenyl)-2H-benzotriazole, HMEPB / 0.8 g of I819, and the mixture was stirred at room temperature for 1 hour to complete the silver / silicone hydrogel combination solution. The solution was injected into a mold and subjected to blue light curing for 60 minutes to form a silicone hydrogel dry sheet. After cleaning with room temperature alcohol and water solution, the dry sheet was placed in a phosphate buffer and subjected to high temperature sterilization at 121°C for 30 minutes. In this way, an anti-blue light / anti-UV silicone hydrogel contact lens was completed. The following table shows the results of the examples

[0043] Table 1

[0044] SHy SAg10 SAg50 SAg100 SAg200 Refraction index / water content % 1.400 / 52.6 1.398 / 56.3 1.395 / 58.6 1.393 / 62.6 1.390 / 62.4 Oxygen permeability (DK, barrers) 75.0 78.6 82.5 82.4 83.3 Tensile strength (MPa) 1.6 1.2 1.2 1.0 0.7 Elastic modulus (MPa) 0.65 0.61 0.51 0.48 0.47 Elongation (%) 85.2 86.3 88.5 75.3 57.1

[0045] As can be seen from Table 1, the physical properties of the lenses produced in each example are not significantly different, which shows that the lenses produced by the method of the present application meet the standard requirements for contact lenses.

[0046] Table 2

[0047] SHy SAg10 ppm SAg50 SAg100 SAg200 Visible light transmittance a %]] 96.2 93.5 92.7 90.5 88.2 Blue light transmittance / block b %]] 94.2 / 5.8 81.6 / 18.4 74.8 / 25.2 57.9 / 42.1 45.8 / 55.2 UVA transmission / block c %]] 92.3 / 7.7 5.2 / 94.2 3.2 / 96.8 2.0 / 98.0 1.2 / 98.8 UVB transmittance / block d %]] 78.8 / 21.2 0.1 / 99.9 0.1 / 99.9 0.1 / 99.9 0.1 / 99.9

[0048] a indicates wavelength of 380-780 nm

[0049] b indicates wavelength of 380-460 nm

[0050] c indicates wavelength of 316-380 nm

[0051] d indicates wavelength of 281-315 nm

[0052] The results of the example are further analyzed below.

[0053] The contact lenses produced in this example gradually change color from yellow to light yellow with increasing silver ions, but the color does not form a deep yellow at 200 ppm, which affects the appearance of wearing, and the uniform distribution of nano-silver on the body is also proved by the SPR effect.

[0054] As shown in Table 1, when the silver ion concentration increases from 10 ppm to 200 ppm, the refractive index gradually decreases, and the water content gradually increases, but the change is not obvious, which shows that nano-silver still blocks the light starting energy, affects the degree of photopolymerization, and makes the body structure more loose, which causes the water content to increase, and the strength and elongation rate decrease, but at the maximum amount of 200 ppm silver ions, it is only about 10% lower than the control (SAg) and the lens appearance shape is not distorted or deformed. There is no significant difference in lens diameter, radius of curvature, and central thickness compared to the control. In addition, different silver ion concentrations have no significant difference in oxygen permeability, which can reach about 80 Dk, and the water content is more than 50%, which shows that it has superior properties of silicone hydrogel contact lenses.

[0055] As shown in Table 2 and Figure 1 Table 2 shows the changes in the optical properties of the lenses produced in the example, and the addition of UV absorbers can significantly increase the anti-UV ability, which can reach Class I level (UVA> 90%, UVB> 99%), and about 20% of the anti-blue light ability is achieved at 10 ppm of silver ion concentration, which shows that the process has excellent reduction ability for silver ions. The visible light transmittance is more than 90%, which shows that it does not affect vision correction, and the nano-silver at 200 ppm can achieve about 50% of the anti-blue light ability, which shows that the nano-silver and the blue light blocking rate have a very high correlation

[0056] In addition, those skilled in the art should understand that although there are many problems in the prior art, each embodiment or technical solution of the present application can only improve in one or several aspects, and it is not necessary to solve all the technical problems listed in the prior art or background art at the same time. Those skilled in the art should understand that what is not mentioned in a claim should not be considered as a limitation on the claim.

[0057] Although the terms are used more frequently in this paper, the possibility of using other terms is not excluded. The use of these terms is only to facilitate the description and explanation of the essence of the present application; any additional limitation is contrary to the spirit of the present application.

[0058] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present application, and are not intended to limit the present application; although the present application has been described in detail with reference to the above embodiments, those skilled in the art should understand that the technical solutions recorded in the above embodiments can be modified, or some or all of the technical features can be replaced by equivalents; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the scope of the technical solutions of the embodiments of the present application.

Claims

1. A method of manufacturing an anti-blue light contact lens, characterized by, The method comprises the following steps: a. synthesizing a polysiloxane prepolymer, wherein the polysiloxane prepolymer contains polyethylene glycol; b. dissolving a silver ion compound in a non-aqueous solvent to prepare a silver ion solution; c. mixing the silver ion solution with the polysiloxane prepolymer to uniformly distribute silver ions in the silver ion solution in the polysiloxane prepolymer; d. adding a hydrophilic monomer and a photoinitiator to the polysiloxane prepolymer to form a silicone hydrogel composition; and e. irradiating the silicone hydrogel composition with blue light to simultaneously perform a crosslinking and curing reaction and a silver ion reduction reaction to form a silicone hydrogel lens with blue light-resistant nano-silver. In the silicone hydrogel composition of step d, the content of the polysiloxane prepolymer plus the silicon-containing monomer is 30-80 wt%, the content of the repeating units of the hydrophilic monomer is 10-50 wt%, the content of the photoinitiator is 0.1-2 wt%, and the content of the silver ion compound is 10-200 ppm.

2. The manufacturing method according to claim 1, characterized by: The synthesis of the polysiloxane prepolymer in the step comprises the following steps: reacting a dihydroxy polydimethylsiloxane compound and an isocyanate compound in a diluent at a moderate temperature to obtain a first product; adding the first product to a hydrophilic chain extender, sequentially performing a terminal hydroxylation reaction and then a chain extension reaction to obtain a second product; continuing to react the second product and an acrylate compound at room temperature for at least 12 hours to obtain a dual-silicon-containing prepolymer; wherein the hydrophilic chain extender is selected from the group consisting of ethylene glycol, propylene glycol, 1,4-butanediol, polyethylene glycol, polypropylene glycol, polypropylene glycol diglycidyl ether, and combinations thereof.

3. The manufacturing method of claim 1, wherein: The silicone hydrogel composition further comprises 10-20 wt% of a diluent.

4. The manufacturing method of claim 1, wherein: The silicon-containing monomer is selected from the group consisting of 3-methacryloxypropyl tris(tirmethylsiloxy)silane, 3-acryloxypropyl tri(trimethylsiloxy)silane, 3-acrylamidopropyl tris(trimethylsiloxy)silane, 3-methacrylamidopropyl tris(trimethylsiloxy)silane, (3-methacryloxy-2-hydroxypropoxy)propyl bis(trimethylsiloxy)methylsilane, and combinations thereof; and further comprises a monofunctional polydimethylsiloxane with a number average molecular weight of 657-1500.

5. The manufacturing method of claim 1, wherein: wherein the hydrophilic monomer is selected from the group consisting of 2-hydroxyethyl methacrylate (HEMA); N,N-dimethyl acrylamide (DMA), N,N-diethyl acrylamide (DEA), N-vinyl pyrrolidone (NVP), glycerol methacrylate (GMA), polyethylene glycol methacrylate monomethyl ether with a molecular weight of 400, and combinations thereof.

6. The production method according to claim 1, characterized by: In the step d, an ultraviolet blocking monomer is further added, wherein the content of the ultraviolet blocking monomer is 0.1-1.5 wt%.

7. The manufacturing method according to claim 6, characterized in that: In the step d, an ultraviolet blocking monomer is further added, wherein the content of the ultraviolet blocking monomer is 0.1-1.5 wt%.

8. A material for manufacturing anti-blue light eyeglass lenses, comprising the silica hydrogel composition in the manufacturing method according to any one of claims 1-7.

9. An anti-blue light eyeglass lens manufactured by the manufacturing method according to any one of claims 1-7.

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