A tilmicosin premix and its preparation method

Abstract

The present invention relates to a tilmicosin premix and a preparation method thereof. The tilmicosin premix comprises the following raw materials in percentage by weight: 10-20% of tilmicosin; 70-80% of medicinal herb pieces; 1-5% of taste masking agent; 1-5% of feeding attractant; wherein, the medicinal herb pieces include medicinal herb pieces A, and the medicinal herb pieces A include one or both of Poria cocos and Pueraria lobata. The operation of the present invention is simple and the cost is low. It can improve the palatability of tilmicosin and completely solve a series of problems such as the decrease in feed intake caused by the bitter taste of tilmicosin.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a tilmicosin premix and a preparation method thereof. Background Art

[0002] Tilmicosin is mainly used to prevent and treat livestock pneumonia, avian mycoplasma disease and mastitis in lactating animals, and is one of the commonly used drugs in livestock and poultry farming. However, due to its bitter taste, tilmicosin can cause adverse symptoms such as anorexia, nausea, and vomiting in livestock and poultry during oral administration, affecting the appetite of livestock and poultry, thereby greatly reducing the feed intake of livestock and poultry, resulting in insufficient dosage and affecting the treatment effect.

[0003] To solve the above problems, there are currently several common treatment methods: 1) preparing gastric-coated and enteric-coated preparations to mask the bitter taste of tilmicosin and increase the intake of tilmicosin by livestock and poultry, but it has the practical problems of high technical requirements, high cost and low acceptance on the breeding side; 2) adding masking agents and attractants to improve its palatability and induce animals to feed, but the effect is good only when used for the first time. As the number of uses increases, the effect becomes worse and worse. Therefore, it can only solve the problem caused by the bitter taste of tilmicosin to a certain extent, but cannot completely solve it.

[0004] Therefore, it is extremely important to develop a method for preparing a tilmicosin premix to improve the palatability of tilmicosin and completely solve a series of problems such as decreased feed intake due to the bitter taste of tilmicosin. Summary of the invention

[0005] The purpose of the present invention is to overcome the defects in the prior art and provide a tilmicosin premix and a preparation method thereof, which are simple to operate and low in cost, can improve the palatability of tilmicosin, and completely solve a series of problems such as decreased feed intake caused by the bitter taste of tilmicosin.

[0006] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0007] Technical solution 1:

[0008] A tilmicosin premix comprises the following raw materials in percentage by weight:

[0009]

[0010] Wherein, the medicinal material decoction pieces include medicinal material decoction pieces A, and the medicinal material decoction pieces A include one or two of Poria cocos and Pueraria root.

[0011] As a further technical solution, the medicinal slices also include medicinal slices B, the medicinal slices B are made of tangerine peel, and the mass ratio of the medicinal slices A to the medicinal slices B is 1:0.2-0.5.

[0012] As a further technical solution, the taste masking agent is 1-5%, and the appetite attractant is 1-5%.

[0013] Technical solution 2:

[0014] A method for preparing a tilmicosin premix comprises the following steps:

[0015] Step 1, ultrafine pulverizing tilmicosin, and sieving to prepare ultrafine tilmicosin powder;

[0016] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution;

[0017] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and drying after all the tilmicosin solution is completely adsorbed; the medicinal material slices include one or two of Poria cocos slices and Pueraria root slices;

[0018] Step 4: crushing and sieving the medicinal material slices adsorbed with tilmicosin to prepare premix granules to obtain tilmicosin premix.

[0019] As a further technical solution, in step 4, after the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent and / or an appetite attractant is added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0020] As a further technical solution, the taste masking agent includes neomethyl hesperidin dihydrochalcone;

[0021] The attractant is sodium butyrate.

[0022] As a further technical solution, in step 1, the sieve used for screening is 250-300 mesh.

[0023] As a further technical solution, in step 3, the tilmicosin solution is added to the medicinal material slices at a volume ratio of 1:1.5-2.5 between the solid and liquid volumes.

[0024] As a further technical solution, the medicinal material pieces also include dried tangerine peel pieces.

[0025] As a further technical solution, in step 3, the drying temperature is 60-65° C. and the drying time is 4-5 hours.

[0026] As a further technical solution, in step 4, the sieving uses 40 mesh.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The invention adds Poria cocos, Pueraria root and dried orange peel to the tilmicosin premix, wherein Poria cocos can invigorate the spleen and stop diarrhea (the spleen invigoration of traditional Chinese medicine is effective through the regulation of intestinal flora), and reduce the drug side effects caused by the destruction of intestinal flora by tilmicosin; Pueraria root has the effects of relieving muscle and reducing fever, clearing rash, promoting body fluid and relieving thirst, and raising yang and stopping diarrhea, and can reduce the side effects of yang damage caused by the large-scale application of tilmicosin; and dried orange peel has a fragrant smell, has the effects of invigorating the spleen and appetizing, regulating qi and digesting food, and drying dampness and removing phlegm, and can not only cooperate with tilmicosin to treat respiratory diseases and improve the treatment effect, but also has the effect of a taste masking agent.

[0029] The present invention uses medicinal slices to adsorb tilmicosin and then crushes them. When the medicinal slices with larger particles are used for adsorption, the operation is convenient and the material-liquid ratio is easy to control. Compared with the use of medicinal powder with smaller particle size for adsorption, the medicinal cells are complete and the aqueous solution is easy to absorb. Tilmicosin can be adsorbed into the inside of the medicinal cells instead of being exposed outside the medicinal cells, thereby playing a taste masking role. The reduction of the absorption effect of the aqueous solution caused by the dissolution of cell components in the crushed medicinal powder and the incomplete absorption of the aqueous solution are avoided, and the problem that tilmicosin cannot be adsorbed into the inside of the medicinal cells is also avoided. In addition, Poria cocos and Pueraria root have higher water absorption coefficients and better adsorption effects on tilmicosin.

[0030] Before the adsorption treatment of tilmicosin by using the medicinal material slices, the present invention needs to ultrafinely powder the tilmicosin, which facilitates the entry of tilmicosin into the medicinal material cells instead of exposing tilmicosin outside the medicinal material cells, thereby achieving the taste masking effect.

[0031] The present invention strictly limits the particle size of the medicinal material slices to avoid cell wall breakage due to over-fine grinding, thereby exposing too much tilmicosin and failing to achieve the effect of adsorption and taste masking. In addition, after the medicinal material slices are crushed, part of the tilmicosin will inevitably be exposed on the surface of the obtained premix particles. Although the amount of exposure is extremely small, it will also produce a relatively small amount of bitterness. To solve this problem, the present invention also adds a taste masking agent after the medicinal material slices are crushed, which can solve the bitterness caused by the extremely small amount of tilmicosin exposed on the surface of the premix.

[0032] The invention also adds sodium butyrate, an attractant, which can induce livestock and poultry to eat and increase feed intake. DETAILED DESCRIPTION

[0033] In the present invention, the Poria cocos slices are in a square shape, with a length, width and height of 0.8-1.2 cm; the Pueraria root slices are in a square shape, with a length, width and height of 0.5-1 cm; the tangerine peel slices are in a filament shape, with a length, width and height of 0.7-1.3 cm and a thickness of 0.2-0.6 cm.

[0034] The present invention is further described in detail below with reference to the embodiments.

[0035] Embodiment 1:

[0036] A tilmicosin premix comprises the following raw materials in parts by weight:

[0037]

[0038] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0039] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0040] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0041] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0042] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0043] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0044] Embodiment 2:

[0045] A tilmicosin premix comprises the following raw materials in parts by weight:

[0046]

[0047] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0048] Step 1, ultrafine powdering tilmicosin, and passing through a 250-mesh sieve to prepare ultrafine tilmicosin powder;

[0049] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0050] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0051] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0052] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0053] Embodiment 3:

[0054] A tilmicosin premix comprises the following raw materials in parts by weight:

[0055]

[0056] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0057] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0058] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0059] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0060] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0061] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0062] Embodiment 4:

[0063] A tilmicosin premix comprises the following raw materials in parts by weight:

[0064]

[0065] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0066] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0067] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0068] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices and the Pueraria root slices;

[0069] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0070] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0071] Example 5

[0072] A tilmicosin premix comprises the following raw materials in parts by weight:

[0073]

[0074] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0075] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0076] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0077] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0078] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0079] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone, is added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0080] Comparative Example 1

[0081] A tilmicosin premix comprises the following raw materials in parts by weight:

[0082]

[0083] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0084] Step 2, dissolving tilmicosin (particle size 80 mesh) in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0085] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0086] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through a 40-mesh sieve, and prepare premix granules.

[0087] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0088] Comparative Example 2

[0089] A tilmicosin premix comprises the following raw materials by weight:

[0090]

[0091]

[0092] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0093] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0094] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0095] Step 3, adding the tilmicosin solution to the medicinal material slices, adsorbing the tilmicosin, and baking at 65° C. for 4 hours until dry after all the tilmicosin solution is completely adsorbed; the medicinal material slices are prepared by uniformly mixing the Poria cocos slices, the Pueraria root slices, and the dried orange peel;

[0096] Step 4: crush the medicinal material slices adsorbed with tilmicosin, pass through an 80-mesh sieve, and prepare premix granules.

[0097] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0098] Comparative Example 3

[0099] A tilmicosin premix comprises the following raw materials in parts by weight:

[0100]

[0101] A method for preparing a tilmicosin premix, characterized in that it comprises the following steps:

[0102] Step 1, ultrafine tilmicosin, and pass through a 300-mesh sieve to prepare ultrafine tilmicosin powder;

[0103] Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution with a mass concentration of 20%;

[0104] Step 3, crush the medicinal material slices, pass through a 40-mesh sieve, and obtain medicinal material granules;

[0105] Step 4: adding the tilmicosin solution to the medicinal material granules to adsorb the tilmicosin, and after all the tilmicosin solution is completely adsorbed, baking at 65° C. for 4 hours until dry to prepare premix granules.

[0106] Step 5: After the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent, neomethyl hesperidin dihydrochalcone and an attractant, sodium butyrate, are added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

[0107] Effect example 1:

[0108] 80 fattening pigs weighing about 60 kg were randomly selected and divided into 8 groups, each with 10 pigs. The medication was carried out according to the following groups. In terms of tilmicosin, 1 kg of the prepared sample was added per ton of feed, and then the feed intake of each pig was observed. The results are shown in Table 1;

[0109] Grouping:

[0110] Experimental group 1: The Tilmicosin premix prepared in Example 1 was used for administration;

[0111] Experimental group 2: The tilmicosin premix prepared in Example 4 was used for administration;

[0112] Experimental group 3: The tilmicosin premix prepared in Example 5 was used for administration;

[0113] A control group: the Tilmicosin premix prepared in Comparative Example 1 was administered;

[0114] Control group 2: The tilmicosin premix prepared in comparative example 2 was used for administration;

[0115] Control group 3: The tilmicosin premix prepared in comparative example 3 was administered;

[0116] Four control groups: Tilmicosin original drug administration;

[0117] Blank control group: no medication;

[0118] Table 1

[0119]

[0120] From the above data, it can be seen that Example 1 and the blank control group have slightly increased their food intake due to the addition of sodium butyrate to improve food inducement. In Comparative Example 1, because Tilmicosin was not micronized, it could not be completely adsorbed into the traditional Chinese medicine, which significantly reduced the food intake; Comparative Example 2 was crushed to a small particle size, resulting in partial exposure of the adsorbed Tilmicosin and a certain bitterness, which led to a decrease in food intake; Comparative Example 3 was crushed before adsorption, resulting in the dissolution of the traditional Chinese medicine components, incomplete absorption of the Tilmicosin aqueous solution, and exposure outside the medicinal material cells, resulting in a decrease in the taste masking effect, affecting the food intake. Example 5 lacks sodium butyrate to induce food, so it leads to a slight change in food intake.

[0121] Effect Example 2

[0122] 80 pigs with bacterial respiratory tract diseases were selected and randomly divided into 4 groups, 20 pigs in each group, and the drugs were administered according to the following groups. The therapeutic effect was observed. The cure rate and treatment time were used as reference indicators. The results are shown in Table 2.

[0123] Grouping:

[0124] Experimental group 1: The Tilmicosin premix prepared in Example 1 was used for administration;

[0125] Experimental group 2: The tilmicosin premix prepared in Example 4 was used for administration;

[0126] A comparison group: Tilmicosin original drug was used for administration;

[0127] Blank control group: no medication;

[0128] Grouping Cure rate% Treatment duration Example 1 100 5 days Example 4 100 7 days Compare a group 65 8 days Blank control group 20 7 days

[0129] The above-described embodiments are only preferred embodiments of the present invention, and are not exhaustive of the feasible implementations of the present invention. For those skilled in the art, any obvious changes made thereto without departing from the principles and spirit of the present invention should be considered to be included in the scope of protection of the claims of the present invention.

Claims

1. A tilmicosin premix, It is characterized in that The raw materials include the following weight percentages: Tilmicosin 10-20%; 70-80% of medicinal materials; Taste masking agent 0-5%; Attractant 0-5%; Wherein, the medicinal material slices include medicinal material slices A, and the medicinal material slices A include one or two of Poria cocos and Pueraria root; the preparation method of the tilmicosin premix comprises the following steps: Step 1, ultrafine pulverizing tilmicosin, and sieving to prepare ultrafine tilmicosin powder; In step 1, the sieve used for sieving is 250-300 mesh; Step 2, dissolving the tilmicosin ultrafine powder in water to prepare a tilmicosin solution; Step 3, adding the tilmicosin solution to the medicinal material slices to adsorb the tilmicosin, and drying after all the tilmicosin solution is completely adsorbed; In step 3, the tilmicosin solution is added to the medicinal material slices at a volume ratio of 1:1.5-2.5; Step 4, crushing and sieving the medicinal material slices adsorbed with tilmicosin to prepare premix granules to obtain a tilmicosin premix; In step 4, the sieving is performed using a 40-mesh sieve; In step 4, after the adsorbent adsorbed with tilmicosin is crushed into premix particles, a taste masking agent and / or an appetite attractant is added to the premix particles, and the mixture is stirred and mixed to obtain a tilmicosin premix.

2. A tilmicosin premix according to claim 1, It is characterized in that The medicinal slices also include medicinal slices B, wherein the medicinal slices B are made of tangerine peel, and the mass ratio of the medicinal slices A to the medicinal slices B is 1:0.2-0.

5.

3. A tilmicosin premix according to claim 1, It is characterized in that The taste masking agent includes neomethyl hesperidin dihydrochalcone; The attractant is sodium butyrate.

4. A tilmicosin premix according to claim 1, It is characterized in that In step 3, the drying temperature is 60-65° C. and the drying time is 4-5 hours.

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