Contaminant cleaning monitoring compositions, contaminant cleaning monitoring labels, and methods of making the same

Abstract

This invention provides a contaminant cleaning monitoring composition, a contaminant cleaning monitoring tag, and a method for preparing the same. Specifically, the contaminant cleaning monitoring composition, based on 100% by weight, comprises: 1-20% by weight gelatin; 0.1-5% by weight a polymer binder selected from one or more of polyurethane, acrylic, and cellulose adhesives; 0.1-5% by weight a colorant; and the balance being water. The contaminant cleaning monitoring tag comprises: a substrate; and a dried contaminant cleaning monitoring composition attached to the substrate. The contaminants formed by the contaminant cleaning monitoring composition according to the invention after drying can effectively simulate dried blood commonly encountered during medical device cleaning processes. In particular, the contaminant cleaning monitoring tag made using this contaminant cleaning monitoring composition exhibits excellent linear elution behavior and can be effectively used to monitor medical contaminant cleaning processes.

Description

Technical Field

[0001] This invention relates to the field of medical device cleaning technology. Specifically, this invention provides a contaminant cleaning monitoring composition, a contaminant cleaning monitoring tag, and a method for preparing the same. Background Technology

[0002] In the daily operations of hospitals, cleaning machines are frequently used to clean used medical devices. During the cleaning process, various medical device cleaning effectiveness monitoring cards are typically used to monitor the specific cleaning progress of contaminants on the medical devices. These monitoring cards usually simulate the elution behavior of contaminants such as proteins, fats, and polysaccharides to provide information on the cleaning status of these contaminants.

[0003] Currently, it is of great significance to develop a cleaning label product that can effectively monitor the cleaning status of contaminants in cleaning machines. Summary of the Invention

[0004] Based on the technical problems described above, the purpose of this invention is to provide a contaminant cleaning monitoring composition, a contaminant cleaning monitoring tag, and a method for preparing the same. The contaminants formed by the contaminant cleaning monitoring composition according to this invention after drying can effectively simulate dried blood commonly encountered during medical device cleaning. Furthermore, the contaminant cleaning monitoring tag made using this composition exhibits excellent linear elution behavior and can be effectively used to monitor the cleaning process of medical contaminants in cleaning machines. Specifically, the components in the contaminant cleaning monitoring tag according to this invention can be eluted simultaneously during the cleaning process, exhibiting excellent linear elution behavior, which is beneficial for evaluating the cleaning effect.

[0005] The inventor completed this invention through in-depth and meticulous research.

[0006] According to one aspect of the present invention, a contaminant cleaning and monitoring composition is provided, the contaminant cleaning and monitoring composition comprising, by weight, 100% of its total weight:

[0007] 1-20% by weight of gelatin;

[0008] 0.1-5% by weight of a polymeric adhesive, wherein the polymeric adhesive is selected from one or more of polyurethane adhesives, acrylic adhesives, and cellulose adhesives;

[0009] 0.1-5% by weight of pigment; and

[0010] The remaining water.

[0011] According to another aspect of the present invention, a contaminant cleaning monitoring tag is provided, comprising:

[0012] Substrate; and

[0013] A marker attached to the substrate, the marker being formed by applying the contaminant cleaning and monitoring composition according to the above description to the substrate and then drying it.

[0014] According to another aspect of the present invention, a method for preparing a contaminant cleaning monitoring tag is provided, comprising:

[0015] Provide substrates; and

[0016] The pollutant cleaning and monitoring composition described above is applied to the substrate and dried to form a marker.

[0017] Compared to conventional commercial medical device cleaning effectiveness testing cards in the field, the contaminant cleaning monitoring tag of the present invention has the advantage of being more effective in monitoring the cleaning process of dried blood-like medical contaminants in cleaning machines. Specifically, the components in the contaminant cleaning monitoring tag of the present invention can be eluted simultaneously during the cleaning process and exhibit excellent linear elution behavior, which is beneficial for evaluating the cleaning effect. Attached Figure Description

[0018] The accompanying drawings, which are incorporated herein and form part of this specification, illustrate exemplary embodiments of the invention and, together with the general description provided above and the detailed description provided below, serve to explain the features of the invention.

[0019] Figure 1 The graph shows a comparison of the cleaning monitoring effects of cleaning labels prepared using commercial medical device cleaning effect test cards and in Examples 1, 2, 5, 6 and 10 of this application for multi-enzyme cleaning agents (where: the x-axis is the dilution concentration (dilution factor) of the multi-enzyme cleaning agent; the y-axis is the time (s) it takes for the marker on the cleaning label to be washed off). Detailed Implementation

[0020] It should be understood that, without departing from the scope or spirit of this disclosure, those skilled in the art can conceive of various other embodiments and can modify them based on the teachings of this specification. Therefore, the following specific embodiments are not intended to be limiting.

[0021] Unless otherwise specified, all figures used in this specification and claims to indicate feature dimensions, quantities, and physical properties should be understood to be modified by the term "about" in all cases. Therefore, unless stated to the contrary, the numerical parameters listed in the foregoing specification and appended claims are approximations, and those skilled in the art can appropriately modify these approximations to obtain the desired characteristics using the teachings disclosed herein. The use of numerical ranges indicated by endpoints includes all numbers within that range and any range within that range; for example, 1 to 5 includes 1, 1.1, 1.3, 1.5, 2, 2.75, 3, 3.80, 4, and 5, etc.

[0022] Current medical device cleaning effectiveness test cards typically simulate the elution behavior of contaminants such as proteins, fats, and polysaccharides to provide information on the cleaning status of these contaminants. However, the inventors of this invention have discovered that these existing commercial medical device cleaning effectiveness test cards differ significantly from dried blood (blood stains) contaminants most commonly found in hospital cleaning operations, failing to accurately simulate the cleaning process of dried blood contaminants. Furthermore, the goodness of fit (R) of existing commercial medical device cleaning effectiveness test cards, as mentioned in the Examples section herein, for characterizing elution behavior is typically below 0.86, leading to the tendency for pigments to be eluted first during cleaning monitoring, making it difficult for all components to be eluted uniformly and simultaneously. The inventors of this invention have discovered that by employing specific components and their specific amounts, a contaminant cleaning monitoring composition for cleaning machines can be provided. The components of the marker in the contaminant cleaning monitoring label formed from the contaminant cleaning monitoring composition can be eluted simultaneously during the cleaning process, exhibiting excellent linear elution behavior, which is beneficial for evaluating cleaning effectiveness. The contaminant cleaning monitoring label according to the present invention is particularly suitable for monitoring the cleaning process of dried blood contaminants in cleaning machines.

[0023] Specifically, according to one aspect of the present invention, a contaminant cleaning and monitoring composition is provided, the contaminant cleaning and monitoring composition comprising, by weight, 100% of its total weight:

[0024] 1-20% by weight of gelatin;

[0025] 0.1-5% by weight of a polymeric adhesive, wherein the polymeric adhesive is selected from one or more of polyurethane adhesives, acrylic adhesives, and cellulose adhesives;

[0026] 0.1-5% by weight of pigment; and

[0027] The remaining water.

[0028] According to the technical solution of the present invention, a contaminant cleaning and monitoring composition for cleaning monitoring tags can be provided by using a specific ratio of gelatin, a specific polymer binder, and colorants. The marker formed from this contaminant cleaning and monitoring composition can effectively simulate the elution behavior of dried blood contaminants under the cleaning action of a multi-enzyme cleaning agent. Furthermore, the marker exhibits excellent linear elution behavior, which is beneficial for evaluating the cleaning effect.

[0029] The contaminant cleaning and monitoring composition according to the present invention comprises gelatin as an essential component. Preferably, the weight-average molecular weight of the gelatin is in the range of 50,000 to 150,000. Specific examples of gelatin products that can be used in the present invention include gelatin produced by China National Pharmaceutical Group Chemical Reagent Co., Ltd., with a weight-average molecular weight of approximately 60,000-150,000. Based on 100% by weight of the total weight of the contaminant cleaning and monitoring composition, the contaminant cleaning and monitoring composition comprises 1-20% by weight, preferably 5-20% by weight, of gelatin. When the gelatin content is less than 1% by weight, the marker formed by the contaminant cleaning and monitoring composition is washed away in a very short time, making it unsuitable for monitoring the cleaning process in a cleaning machine; when the gelatin content is greater than 20% by weight, the marker formed by the contaminant cleaning and monitoring composition requires a longer time to be washed away by the multi-enzyme detergent, making it unsuitable for monitoring the cleaning process in a cleaning machine.

[0030] The contaminant cleaning and monitoring composition according to the present invention comprises a polymer binder as an essential component, said polymer binder being selected from one or more of polyurethane binders, polyacrylic binders, and cellulose binders. Preferably, the weight-average molecular weight of the polymer binder is in the range of 10,000 to 800,000. Preferably, the viscosity of the polymer binder at 25°C is in the range of 200-600 mPa·s. Preferably, the cellulose binder is hydroxyethyl cellulose. Specific examples of polymer binder products that can be used in the present invention include: hydroxyethyl cellulose produced by China National Pharmaceutical Group Chemical Reagent Co., Ltd., with a weight-average molecular weight in the range of 200,000-800,000; the polyurethane binder NeoRezTMR-966 produced by NZM, with a viscosity of 200-600 mPa·s at 25°C; and the polyacrylic binder Neocryl A-1092 produced by NZM, with a viscosity of 200-600 mPa·s at 25°C. Based on 100% by weight of the total weight of the contaminant cleaning monitoring composition, the contaminant cleaning monitoring composition contains 0.1-5% by weight, preferably 0.1-2% by weight of the polymer binder. When the content of the polymer binder is less than 0.1% by weight, the marker formed by the contaminant cleaning monitoring composition is washed away in a very short time, making it unsuitable for monitoring the cleaning process in a cleaning machine; when the content of the polymer binder is greater than 5% by weight, the marker formed by the contaminant cleaning monitoring composition requires a longer time to be washed away by the multi-enzyme detergent, making it unsuitable for monitoring the cleaning process in a cleaning machine.

[0031] The contaminant cleaning and monitoring composition according to the present invention comprises a colorant as an essential component. Preferably, the colorant is a red colorant. More preferably, the colorant is a yellow-phase iron red. Specific examples of colorants that can be used in the present invention include yellow-phase iron red Colynal Red manufactured by Clariant. The contaminant cleaning and monitoring composition comprises 0.1-5% by weight, preferably 0.1-1% by weight, of the colorant, based on 100% by weight of the total weight of the contaminant cleaning and monitoring composition.

[0032] There are no particular limitations on the specific method for preparing the pollutant cleaning and monitoring composition according to the present invention, which can be prepared by simply mixing the various components contained in the pollutant cleaning and monitoring composition.

[0033] According to another aspect of the present invention, a contaminant cleaning monitoring tag is provided, comprising:

[0034] Substrate; and

[0035] The markers are attached to the substrate and formed by applying the above-described contaminant cleaning and monitoring composition to the substrate and then drying it.

[0036] Preferably, the substrate is a sheet substrate, preferably a plastic film, and more preferably a PET film.

[0037] According to another aspect of the present invention, a method for preparing a contaminant cleaning monitoring tag is provided, comprising:

[0038] Provide substrates; and

[0039] The pollutant cleaning and monitoring composition described above is applied to the substrate and dried to form a marker.

[0040] Preferably, the substrate is a sheet substrate, more preferably a plastic film, and more preferably a PET film. Preferably, the marker is a circular marker located at the center of the substrate.

[0041] The following list of embodiments further illustrates various exemplary embodiments of the invention, which should not be construed as unduly limiting the invention:

[0042] Specific embodiment 1 is a pollutant cleaning and monitoring composition, wherein the pollutant cleaning and monitoring composition comprises, by weight 100%, the following:

[0043] 1-20% by weight of gelatin;

[0044] 0.1-5% by weight of a polymeric adhesive, wherein the polymeric adhesive is selected from one or more of polyurethane adhesives, acrylic adhesives, and cellulose adhesives;

[0045] 0.1-5% by weight of pigment; and

[0046] The remaining water.

[0047] Specific implementation scheme 2 is based on the pollutant cleaning and monitoring composition described in specific implementation scheme 1, wherein the weight-average molecular weight of the gelatin is in the range of 50,000 to 150,000.

[0048] Specific implementation scheme 3 is the pollutant cleaning and monitoring composition according to specific implementation scheme 1, wherein the pollutant cleaning and monitoring composition contains 5-20% by weight of the gelatin.

[0049] Specific implementation scheme 4 is based on the pollutant cleaning and monitoring composition described in specific implementation scheme 1, wherein the weight average molecular weight of the polymer adhesive is in the range of 10,000 to 800,000.

[0050] Specific implementation scheme 5 is a pollutant cleaning and monitoring composition according to specific implementation scheme 1, wherein the polymer binder has a viscosity in the range of 200-600 mPa·s at 25°C.

[0051] Specific implementation scheme 6 is the pollutant cleaning and monitoring composition according to specific implementation scheme 1, wherein the cellulose binder is hydroxyethyl cellulose.

[0052] Specific embodiment 7 is the pollutant cleaning and monitoring composition according to specific embodiment 1, wherein the pollutant cleaning and monitoring composition comprises 0.1-2% by weight of the polymer binder.

[0053] Specific implementation scheme 8 is the pollutant cleaning and monitoring composition according to specific implementation scheme 1, wherein the colorant is a red colorant.

[0054] Specific implementation scheme 9 is based on the pollutant cleaning and monitoring composition described in specific implementation scheme 1, wherein the colorant is yellow-phase iron red.

[0055] Specific embodiment 10 is the pollutant cleaning and monitoring composition according to specific embodiment 1, wherein the pollutant cleaning and monitoring composition contains 0.1-1% by weight of the pigment.

[0056] Specific implementation plan 11 is a pollutant cleaning monitoring label, including:

[0057] Substrate; and

[0058] A marker attached to the substrate, the marker being formed by applying the contaminant cleaning and monitoring composition according to any one of the foregoing specific embodiments 1-10 to the substrate and then drying it.

[0059] Specific implementation scheme 12 is a pollutant cleaning monitoring label according to specific implementation scheme 11, wherein the substrate is a plastic film.

[0060] Specific implementation plan 13 is a method for preparing a pollutant cleaning monitoring tag, including:

[0061] Provide substrates; and

[0062] The pollutant cleaning and monitoring composition according to any one of the aforementioned specific embodiments 1-10 is applied to the substrate and dried to form a marker.

[0063] Specific implementation scheme 14 is a method for preparing a pollutant cleaning monitoring label according to specific implementation scheme 13, wherein the substrate is a plastic film.

[0064] The present invention will now be described in more detail with reference to embodiments. It should be noted that these descriptions and embodiments are intended to facilitate understanding of the invention and are not intended to limit the invention. The scope of protection of the present invention is defined by the appended claims.

[0065] Example

[0066] In this invention, unless otherwise specified, all reagents used are commercially available products and are used directly without further purification.

[0067] Table 1 Raw Material List

[0068]

[0069] Test methods

[0070] Machine cleaning suitability test for monitoring label samples

[0071] In this application, a multi-enzyme cleaning agent was used to clean the monitoring tag samples prepared in the following examples and comparative examples to determine their suitability for machine cleaning.

[0072] Specifically, 0.5g of multi-enzyme cleaning agent 70508+ was placed in a beaker, and purified water at 40°C was added to dilute it 200 times. The beaker was then placed in a constant-temperature water bath for 30 minutes to ensure the temperature stabilized at 40°C, thus preparing the diluted solution. Subsequently, each cleaning label sample prepared in the following examples and comparative examples was placed in the diluted solution in the beaker, and timing was started. The state of the red markers on the cleaning labels was observed, and timing was stopped when all the red markers were washed away. The total recorded time is the cleaning time.

[0073] Hospitals typically use cleaning machines to clean medical devices. There are technical requirements for the cleaning time of monitoring tags used in these machines; tags with cleaning times that are too short or too long are unsuitable for use. If the measured cleaning time is within the range of 1-15 minutes, the cleaning tag is considered to meet the basic technical requirements for use in cleaning machines; if the measured cleaning time is within the range of 5-10 minutes, the cleaning tag is considered to have excellent cleaning performance.

[0074] Testing the washing and elution behavior of monitored labeled samples

[0075] In this application, a multi-enzyme cleaning agent was used to clean and test the monitoring tag samples prepared in Examples 1, 2, 5, 6 and 10, as well as the commercial medical device cleaning effect test card, to evaluate their elution behavior during the cleaning process.

[0076] Specifically, four 0.5g portions of multi-enzyme cleaning agent 70508+ were placed in four beakers, and purified water at 40°C was added to dilute it by 100, 200, 400, and 800 times, respectively. Then, the four beakers were placed in a constant-temperature water bath for 30 minutes, ensuring the temperature remained stable at 40°C, thus preparing diluents with concentrations diluted 100, 200, 400, and 800 times. Subsequently, four copies of the cleaning label sample prepared in Example 1 below were placed in the diluents in the four beakers, and timing was started. The state of the red markers on the cleaning labels was observed, and timing was stopped when all the red markers were washed away. The total recorded time was the cleaning time. Thus, the cleaning times for multi-enzyme cleaning agent 70508+ diluted 100, 200, 400, and 800 times were obtained. The cleaning times are recorded in Table 4 below.

[0077] The cleaning time of the cleaning label samples prepared in Examples 2, 5, 6 and 10 below was tested in the same manner as the tests conducted on the cleaning label samples prepared in Example 1 above, when the multi-enzyme cleaning agent 70508+ was diluted by 100 times, 200 times, 400 times and 800 times respectively, and the cleaning time is recorded in Table 4 below.

[0078] The cleaning time of the commercial medical device cleaning effect test card was tested in the same manner as the test of the cleaning label sample prepared in Example 1 above, when the multi-enzyme cleaning agent 70508+ was diluted by 100 times, 200 times, 400 times and 800 times respectively, and the cleaning time is recorded in Table 4 below.

[0079] Example 1 (E1)

[0080] 1g of gelatin, 0.5g of hydroxyethyl cellulose, 1g of Colynal Red, and 97.5g of distilled water were uniformly mixed to obtain contaminant cleaning monitoring composition 1. The obtained contaminant cleaning monitoring composition 1 was coated onto the center of a PET film with dimensions of 4cm × 2.5cm × 0.02cm. The PET film coated with contaminant cleaning monitoring composition 1 was then dried at room temperature to obtain monitoring tag 1. The tag formed by coating and drying the contaminant cleaning monitoring composition 1 is circular with a diameter of 2cm and a thickness of 0.015mm.

[0081] Based on the methods for machine cleaning suitability testing and cleaning-elution behavior testing described in detail above, the obtained monitoring label 1 was subjected to machine cleaning suitability testing and cleaning-elution behavior testing, and the results were recorded in Tables 2, 3 and 4 below.

[0082] Examples 2-14 (E2-E14) and Comparative Examples 1-5 (C1-C5)

[0083] Examples 2-14 (E2-E14) and Comparative Examples 1-5 (C1-C5) were prepared in the same manner as Example 1 to prepare monitoring labels 2-14 and comparative detection labels 1-5, except that the specific types and contents of the various components used to prepare the contaminant cleaning monitoring compositions were changed as shown in List 2 and Table 3 below.

[0084] Based on the methods for machine cleaning suitability testing and cleaning-elution behavior testing described in detail above, the obtained monitoring labels 2-14 and comparison test labels 1-5 were subjected to machine cleaning suitability testing and cleaning-elution behavior testing, and the results were recorded in Tables 2, 3 and 4 below.

[0085]

[0086]

[0087] Table 4 shows the elution behavior test results of Examples 1, 2, 5, 6, and 10, as well as the commercial medical device cleaning effect test card.

[0088]

[0089] Note: In the table above, “′” represents minutes; “″” represents seconds.

[0090] Figure 1 The graph shows a comparison of the cleaning monitoring effects of cleaning labels prepared using commercial medical device cleaning effect test cards and in Examples 1, 2, 5, 6 and 10 of this application for multi-enzyme cleaning agents (where: the x-axis is the dilution concentration (dilution factor) of the multi-enzyme cleaning agent; the y-axis is the time (s) it takes for the marker on the cleaning label to be washed off).

[0091] right Figure 1 The data points from various embodiments and the commercial medical device cleaning effect test card were fitted. Specifically, a scatter plot was created with the dilution factor of the enzyme-containing cleaner as the x-axis and the cleaning time as the y-axis. The specific experimental data were filled into the coordinate graph. Then, a linear fitting method was used to fit the dilution factor and the cleaning time, and the square of the goodness of fit "R" was obtained. 2 The larger the square of the goodness of fit, the higher the goodness of fit value.

[0092] The data of the fitting degree R obtained by fitting the commercial medical device cleaning effect test card and the cleaning labels prepared in Examples 1, 2, 5, 6 and 10 of this application are shown in Table 5 below.

[0093] Table 5 shows the goodness of fit (R) of the elution behavior of the commercial medical device cleaning effect test card and the cleaning tags prepared in Examples 1, 2, 5, 6 and 10 of this application.

[0094] goodness of fit R Example 1 0.9948 Example 2 0.995 Example 5 0.9918 Example 6 0.9752 Example 10 0.9802 Commercial Medical Device Cleaning Effect Test Card 0.8546

[0095] A higher R-value indicates a better correlation between the cleaning time of the monitoring tag and the dilution ratio of the multi-enzyme detergent. The R-value of the commercial medical device cleaning effect test card is only 0.8546, while the R-values ​​of the cleaning tags prepared in Examples 1, 2, 5, 6 and 10 of this application range from 0.9752 to 0.995. This demonstrates that the cleaning tag according to the present invention exhibits significantly superior linear elution behavior compared to the commercial medical device cleaning effect test card, which is beneficial for evaluating the cleaning effect.

[0096] As can be seen from the results in Table 2, the contaminant cleaning monitoring composition prepared according to the technical solution of the present invention can be effectively used to monitor the cleaning process of medical contaminants in cleaning machines.

[0097] By comparing Example 1 with Comparative Examples 1 and 2, it can be seen that when the gelatin content in the contaminant cleaning monitoring composition is too low (e.g., 0.1% by weight in Comparative Example 1) or too high (e.g., 30% by weight in Comparative Example 2), the cleaning time of the label sample is too short (e.g., 15″ in Comparative Example 1) or too long (e.g., 17′22″ in Comparative Example 2), and is not suitable for use as a contaminant cleaning monitoring label for cleaning machines.

[0098] By comparing Example 2 with Comparative Examples 3 and 4, it can be seen that when the polymer binder content in the contaminant cleaning monitoring composition is too low (e.g., 0.01% by weight in Comparative Example 3) or too high (e.g., 10% by weight in Comparative Example 4), the cleaning time of the label sample is too short (e.g., 10″ in Comparative Example 3) or too long (e.g., 17′45″ in Comparative Example 4), and is not suitable for use as a contaminant cleaning monitoring label for cleaning machines.

[0099] The results of Comparative Example 5 show that when other polymer adhesives (e.g., polyvinyl alcohol) other than polyurethane adhesives, acrylic adhesives and cellulose adhesives are used, the cleaning time of the label samples is too long (e.g., 25′40″ in Comparative Example 5), and they are not suitable for use as contaminant cleaning monitoring labels for cleaning machines.

[0100] Although specific embodiments have been shown and described herein, those skilled in the art will understand that various alternative and / or equivalent embodiments can be used instead of the shown and described specific embodiments without departing from the scope of the invention. This application is intended to include any improvements or modifications to the specific embodiments discussed herein. Therefore, the invention is limited only to the claims and their equivalents.

[0101] Those skilled in the art will understand that various modifications and alterations can be made without departing from the scope of the invention. Such modifications and alterations are intended to fall within the scope of the invention as defined in the appended claims.

Claims

1. A contaminant cleaning and monitoring composition, wherein the contaminant cleaning and monitoring composition comprises, by weight (100%): 5-20% by weight of gelatin, wherein the weight-average molecular weight of the gelatin is in the range of 50,000 to 150,000; 0.1-5% by weight of a polymeric adhesive, wherein the polymeric adhesive is selected from one or more of polyurethane adhesives, polyacrylic adhesives and hydroxyethyl cellulose, wherein the weight-average molecular weight of the polymeric adhesive is in the range of 10,000 to 800,000. 0.1-5% by weight of a colorant, wherein the colorant is a yellow-phase iron red; and The remaining water.

2. The contaminant cleaning and monitoring composition according to claim 1, wherein the polymer binder has a viscosity in the range of 200-600 mPa·s at 25°C.

3. The contaminant cleaning and monitoring composition according to claim 1, wherein the contaminant cleaning and monitoring composition comprises 0.1-2% by weight of the polymer binder.

4. The pollutant cleaning and monitoring composition according to claim 1, wherein the pollutant cleaning and monitoring composition comprises 0.1-1% by weight of the pigment.

5. A pollutant cleaning monitoring label, comprising: Substrate; and A marker attached to the substrate, the marker being formed by applying the contaminant cleaning and monitoring composition according to any one of claims 1-4 to the substrate and then drying it.

6. The pollutant cleaning monitoring label according to claim 5, wherein the substrate is a plastic film.

7. A method for preparing a pollutant cleaning monitoring tag, comprising: Provide base materials; and The contaminant cleaning and monitoring composition according to any one of claims 1-4 is applied to the substrate and dried to form a marker.

8. The method for preparing the pollutant cleaning monitoring tag according to claim 7, wherein the substrate is a plastic film.

Images