A highly stable whitening and anti-aging atomizing liquid and its preparation method

Abstract

The present invention discloses a highly stable whitening and anti-aging atomizing solution. The preparation raw materials include enzyme activity inhibitors, polysaccharide substances, calcium sodium phosphosilicate, skin conditioners, polypeptides, vitamins, edible flavors, and polar solvents. The obtained atomizing solution can improve the cell discrimination ability and regulate the half-life of blood proteins, thereby effectively enhancing the human immune function; activate the fibroblasts generated by the human dermis, significantly promote the synthesis of collagen in the human body, effectively improve the stratum corneum, promote the skin to be soft and elastic, and make the skin young and plump; can establish a network structure on the skin surface to achieve long-term water locking, effectively relieve skin dryness and desquamation, and form a natural defense barrier for the skin; has super antioxidant ability, and enhances the skin's anti-photoaging and anti-ultraviolet radiation performance. Moreover, it has good thermal stability, and the active ingredients will not decompose under the high temperature condition of 220°C. At the same time, it can promote the rapid atomization of the atomizing solution, and the formed mist has a high saturation.

Description

Technical Field

[0001] The present invention relates to the field of preparation of anti-aging preparations, A61Q19 / 08, and particularly relates to a highly stable whitening and anti-aging atomizing liquid and a preparation method thereof. Background Art

[0002] The skin is an organ with functions of protection, excretion, and perception of external stimuli. Specifically, the skin can be divided into two layers: the epidermis and the dermis. Nowadays, people are increasingly concerned about the maintenance and repair of their skin, so that they can have a young appearance while maintaining a young mindset. However, in the actual process, the skin will undergo irreversible aging due to factors such as irregular work and rest, ultraviolet radiation, computer radiation, and age growth. The skin becomes no longer tender, shiny, and elastic. Among the various whitening and anti-aging products on the market, most are directly used as skin care products and applied to the skin for self-absorption, while relatively few use the functional composition as the atomizing stock solution, and their stability is poor.

[0003] Patent CN202110294558.5 discloses a whitening and anti-aging skin care cream containing collagen tripeptide. The active ingredients are stearic acid, glycerol monostearate, cetyl alcohol, olive oil, traditional Chinese medicine extract, 1 glycerol, potassium hydroxide, collagen tripeptide, and additives. The obtained skin care cream is non-irritating to the skin, has good nutrition and permeability. Collagen tripeptide can be filled in the skin to tighten the skin, soothe and fade wrinkles. However, there are many substances in this skin care cream, and specific equipment is required to obtain high productivity. Patent CN202110151081.5 provides a cosmetic composition with anti-ultraviolet, whitening, and anti-aging functions at the same time, including magnesium ascorbyl phosphate, NMN, green tea extract, sialic acid, and Scutellaria baicalensis root extract, achieving the effects of anti-ultraviolet, whitening, and anti-aging from multiple mechanisms. However, the stability of this composition is poor after being mixed with the matrix. Summary of the Invention

[0004] In order to solve the above problems, in the first aspect of the present invention, a highly stable whitening and anti-aging atomizing liquid is provided. The raw materials for its preparation include: by weight percentage:

[0005] 0.05 - 1.5% enzyme activity inhibitor, 0.15 - 8% polysaccharide, 0.5 - 10% calcium sodium phosphosilicate, 0.02 - 4% skin conditioner, 0.1 - 0.5% polypeptide, 1.5 - 13% vitamin, 2 - 9% edible essence, and polar solvent is added to 100%.

[0006] The enzyme activity inhibitor is selected from one or more of Punica granatum fruit extract, yeast powder, sialic acid, red wine powder, epigallocatechin gallate, and nicotinamide; preferably, the enzyme activity inhibitor is sialic acid.

[0007] Sialic acid, a derivative of a 9-carbon monosaccharide, is an important component of cell membrane proteins. In the system of this application, the addition of sialic acid can make the obtained atomized liquid have the effects of whitening and anti-aging. It is speculated that this may be because sialic acid can inhibit the biological activities of tyrosine hydroxylase and dopa hydroxylase, inhibit the production of melanin, maintain the lifespan of blood cells and the activity and stability of glycoprotein cells in metabolism, and then promote the regeneration of skin cells, achieving the effects of delaying skin aging and beautifying the skin. At the same time, the addition of sialic acid cooperates with the polysaccharide substances in the system, and can also enhance the human immune function, improve the ability to recognize cells, regulate the half-life of blood proteins, have an immune response to familiar antigens, and then inhibit the adhesion and proliferation of viruses on the cell surface, prevent the infection of pathogenic Escherichia coli, and improve the human immune ability. In addition, sialic acid can form an electrostatic bond with the vitamins in the system to promote metabolism.

[0008] The polysaccharide substances are selected from one or more of sodium hyaluronate, chitin, chitin derivatives, proteoglycans, seaweed polysaccharides, ginseng polysaccharides, aloe polysaccharides; preferably, the polysaccharide substances are sodium hyaluronate and proteoglycans.

[0009] The mass ratio of the sodium hyaluronate to the proteoglycan is (0.05 - 6):(0.1 - 2); preferably, the mass ratio of the sodium hyaluronate to the proteoglycan is (0.05 - 3):(0.1 - 1); more preferably, the mass ratio of the sodium hyaluronate to the proteoglycan is 1.65:0.5.

[0010] The sodium hyaluronate is selected from one or more of high molecular weight sodium hyaluronate, medium molecular weight sodium hyaluronate, low molecular weight sodium hyaluronate, ultra-low molecular weight sodium hyaluronate, oligomeric sodium hyaluronate; preferably, the sodium hyaluronate is oligomeric sodium hyaluronate.

[0011] The molecular weight of the oligomeric sodium hyaluronate is 500 - 3000 Da; preferably, the molecular weight of the oligomeric sodium hyaluronate is 776.6 Da.

[0012] The proteoglycan is a food-grade proteoglycan, and the content of the proteoglycan is 99%.

[0013] The addition of sialic acid gives the atomized liquid the effects of whitening and anti-aging. However, its moisturizing performance is poor, and more fine lines will still be caused by long-term lack of water in the skin, leading to aging at different levels. Sodium hyaluronate is a glucuronic acid. By supplementing the components of the intercellular matrix, improving the cell metabolism environment and water balance, it can increase the viscoelasticity of the skin, form a breathable protective film on the skin surface, and achieve the effects of moisturizing and hydrating. However, it is easily washed off. The applicant has found that adding oligomeric sodium hyaluronate to the above system, which has a low molecular weight and strong permeability, can penetrate into the dermis layer of the skin through pores and cell gaps, increase the water content of the skin, and at the same time promote the faster and more absorption of nutrients. Moreover, it can repair damaged cells, improve cell activity and antioxidant capacity. The applicant unexpectedly found that the synergistic effect of oligomeric hyaluronic acid and proteoglycan can not only promote cell development, accelerate metabolism, increase skin elasticity, improve wrinkles, and enhance the anti-ultraviolet performance of the skin, but also further increase the binding force with the skin surface and skin cells, establish a network structure on the skin surface, form a natural protective barrier for the skin, achieve the effects of long-term water locking and high-efficiency moisturizing, and further improve the beauty and anti-aging effects of the atomized liquid.

[0014] The components of the calcium sodium phosphosilicate include SiO2, Na2O, CaO, and P2O5.

[0015] The specific surface area of the calcium sodium phosphosilicate is 350-400m 2 / g, and the D50 particle size is ≤20μm; preferably, the specific surface area of the calcium sodium phosphosilicate is 3790m 2 / g, and the D50 particle size is 5μm.

[0016] The skin conditioner is selected from one or more of β-glucose, fructan, β-nicotinamide adenine dinucleotide, β-alanyl-L-histidine, creatine, sodium polyglutamate, lysate of Saccharomyces cerevisiae fermented product, and fibronectin; preferably, the skin conditioner is β-nicotinamide adenine dinucleotide.

[0017] The polypeptide is selected from one or more of oligopeptide-1, collagen peptide, elastin peptide, collagen tripeptide, acetyl octapeptide-3, palmitoyl pentapeptide-4, palmitoyl tripeptide-1, tripeptide-1 copper, acetyl octapeptide-3, and palmitoyl tetrapeptide-7; preferably, the polypeptide is collagen tripeptide.

[0018] The vitamin is selected from one or more of vitamin A, vitamin B, vitamin C, and vitamin E; preferably, the vitamin is vitamin B and vitamin C.

[0019] The mass ratio of vitamin B to vitamin C is (0.5-7):(1-10); preferably, the mass ratio of vitamin B to vitamin C is 3:4.

[0020] The vitamin B is selected from one or more of vitamin B1, vitamin B6, and vitamin B12; preferably, the vitamin B is vitamin B12.

[0021] The polar solvent is selected from one or more of ethanol, 1,2 - propylene glycol, triethylene glycol, glycerol, tetraethylene glycol, triglycol, and butanediol; preferably, the polar solvent is 1,2 - propylene glycol and glycerol.

[0022] The mass ratio of 1,2 - propylene glycol to glycerol is (1.5 - 3):1; preferably, the mass ratio of 1,2 - propylene glycol to glycerol is 2:1.

[0023] The glycerol is selected from one or more of saponified glycerol, refined glycerol, and hydrolyzed glycerol; preferably, the glycerol is hydrolyzed glycerol; more preferably, the chloride content of the hydrolyzed glycerol is ≤10 mg / kg and the saponification equivalent is ≤0.64 mmol / 100 g; even more preferably, the chloride content of the hydrolyzed glycerol is 3.79 mg / kg and the saponification equivalent is 0.22 mmol / 100 g.

[0024] The atomization stock solution will be dispersed into tiny droplets through pressure atomization, rotary atomization, gas atomization, or acoustic atomization for use. During the atomization process, energy will be released and heat will be generated, affecting the stability of the atomization stock solution. Sodium hyaluronate has poor thermal stability and will decompose with the increase of temperature, reducing its use efficacy. The applicant unexpectedly found that when it is mixed with sialic acid and vitamins and dissolved in a polar solvent composed of 1,2 - propylene glycol and glycerol, the active substances can be fully dissolved, and a system with appropriate viscosity, uniform and stable can be formed. Especially when the glycerol is hydrolyzed glycerol, the viscosity is moderate, and it is not easy to cause phenomena such as the sedimentation of sialic acid, vitamins and protein substances in the system, and the precipitation of calcium sodium phosphosilicate particles. The obtained atomization stock solution can be atomized quickly, has a high atomization saturation, and at the same time, the atomization stock solution has good thermal stability and is not easy to have problems such as the degradation and inactivation of active ingredients during the atomization process. At the same time, it acts synergistically with components such as oligomeric sodium hyaluronate, calcium sodium phosphosilicate, and skin conditioner in the system to further promote cell regeneration, play a moisturizing and anti - aging effect, and can also effectively avoid the adverse problems such as skin irritation caused by 1,2 - propylene glycol during use, and help to improve the smell of the atomized liquid.

[0025] The second aspect of the present invention provides a preparation method of a highly stable whitening and anti - aging atomized liquid, which comprises the following steps:

[0026] (1) Add an enzyme activity inhibitor, a polysaccharide substance, a vitamin, and a food flavor to a polar solvent and stir - mix to obtain a mixture;

[0027] (2) Continuing to add calcium sodium phosphosilicate, skin conditioner, and polypeptide to the mixture obtained in step (1) and stirring continuously to obtain the product.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] (1) In this application, the addition of enzyme activity inhibitor, polysaccharide, calcium sodium phosphosilicate, skin conditioner, polypeptide, vitamin, and edible essence enables the prepared atomized liquid to improve the cell discrimination ability and regulate the half-life of blood proteins, thereby effectively enhancing the human immune function; activating the production of fibroblasts in the human dermis, significantly promoting the synthesis of collagen in the human body, effectively improving the cutin layer, promoting skin softness and elasticity, and making the skin young and plump; being able to establish a network structure on the skin surface to achieve long-term water locking, effectively alleviating skin dryness and desquamation, and forming a natural defense barrier for the skin; having super antioxidant capacity, enhancing the skin's resistance to photoaging and ultraviolet radiation, and having obvious whitening and anti-aging effects.

[0030] (2) In this application, the combined use of a specific ratio of 1,2-propanediol and glycerol helps to enhance the thermal stability of the obtained atomized liquid, and the active ingredients will not decompose under high-temperature conditions of 220°C. At the same time, it can promote the rapid atomization of the atomized liquid, and the formed mist has a high saturation. In addition, the raw materials of the atomized liquid obtained in this application are safe, non-toxic and have no side effects, with a wide range of applications and convenient use. Specific Embodiments

[0031] Example 1:

[0032] 1. A highly stable whitening and anti-aging atomized liquid, the preparation raw materials of which include: by weight percentage:

[0033] 0.3% enzyme activity inhibitor, 2.15% polysaccharide, 5% calcium sodium phosphosilicate, 0.3% skin conditioner, 0.25% polypeptide, 5.5% vitamin, 5% edible essence, and polar solvent added to 100%.

[0034] The enzyme activity inhibitor is sialic acid.

[0035] The polysaccharide is sodium hyaluronate and proteoglycan.

[0036] The mass ratio of sodium hyaluronate to proteoglycan is 1.65:0.5.

[0037] The sodium hyaluronate is oligomeric sodium hyaluronate.

[0038] The molecular weight of the oligomeric sodium hyaluronate is 776.6 Da (Jiangxi Huayuyuan Biotechnology Co., Ltd.).

[0039] The proteoglycan is a food-grade proteoglycan, and the content of the proteoglycan is 99% (purchased from Shaanxi Fuerbang Biotechnology Co., Ltd.).

[0040] The components of the calcium sodium phosphosilicate include SiO2, Na2O, CaO, and P2O5.

[0041] The specific surface area of the calcium sodium phosphosilicate is 350-400 m 2 / g, and the D50 particle size is ≤20 μm; preferably, the specific surface area of the calcium sodium phosphosilicate is 3790 m 2 / g, and the D50 particle size is 5 μm (RegeSi regenerated silicon, purchased from Beijing Xingfu Yisheng High-Tech Co., Ltd.).

[0042] The skin conditioner is β-nicotinamide adenine dinucleotide.

[0043] The polypeptide is collagen tripeptide.

[0044] The vitamins are vitamin B and vitamin C.

[0045] The mass ratio of vitamin B to vitamin C is 2:3.5.

[0046] The vitamin B is vitamin B12.

[0047] The polar solvents are 1,2-propanediol and glycerol.

[0048] The mass ratio of 1,2-propanediol to glycerol is 2:1.

[0049] The glycerol is hydrolyzed glycerol; the chloride content of the hydrolyzed glycerol is 3.79 mg / kg, and the saponification equivalent is 0.22 mmol / 100 g (Yangzhou Feiyang Chemical Co., Ltd.).

[0050] 2. A preparation method of a highly stable whitening and anti-aging atomizing liquid, which comprises the following steps:

[0051] (1) Add an enzyme activity inhibitor, a polysaccharide, vitamins, and a food flavor to a polar solvent and stir to mix to obtain a mixture;

[0052] (2) Continuously add calcium sodium phosphosilicate, a skin conditioner, and a polypeptide to the mixture obtained in step (1) and continue to stir to obtain the product.

[0053] Example 2:

[0054] 1. A highly stable whitening and anti-aging atomizing liquid, which is different from Example 1 in that:

[0055] Its preparation raw materials include: by weight percentage:

[0056] 0.4% enzyme-inhibiting substance, 2% polysaccharide substance, 5% calcium phosphosilicate, 0.35% skin conditioner, 0.3% polypeptide, 5.2% vitamin, 5% edible essence, polar solvent added to 100%.

[0057] 2. A preparation method of a highly stable whitening and anti-aging atomizing liquid is the same as that in Example 1.

[0058] Comparative Example 1:

[0059] 1. A highly stable whitening and anti-aging atomizing liquid, which is different from that in Example 1 in that:

[0060] The sodium hyaluronate is low-molecular-weight sodium hyaluronate.

[0061] The molecular weight of the ultra-low molecular weight sodium hyaluronate is 10,000 Da (purchased from Jining Tangyi Chemical Co., Ltd.)

[0062] 2. A preparation method of a highly stable whitening and anti-aging atomizing liquid is the same as that in Example 1.

[0063] Comparative Example 2:

[0064] 1. A highly stable whitening and anti-aging atomizing liquid, which is different from that in Example 1 in that:

[0065] The mass ratio of the sodium hyaluronate to the proteoglycan is 1.65:2.

[0066] 2. A preparation method of a highly stable whitening and anti-aging atomizing liquid is the same as that in Example 1.

[0067] Comparative Example 3:

[0068] 1. A highly stable whitening and anti-aging atomizing liquid, which is different from that in Example 1 in that:

[0069] The mass ratio of the 1,2-propanediol to the glycerol is 4:1;

[0070] 2. A preparation method of a highly stable whitening and anti-aging atomizing liquid is the same as that in Example 1.

[0071] Performance test:

[0072] 1. Physical and chemical performance test: The sample obtained in Example 1 was tested according to the standard Q / GHJK 008-2021 "Whitening and Anti-aging Functional Atomizing Stock Solution";

[0073] Table 1 Physical and Chemical Performance Test Results of the Atomizing Stock Solution Obtained in the Example

[0074]

[0075] 2. Component test:

[0076] Table 2 Test Results of Component Contents of the Atomized Stock Solution Obtained in Example 1

[0077]

[0078] Sample Pretreatment: First, heat the glass dish in an oil bath for 5 min until the temperature reaches 220°C, then stop heating. Immediately take 2 mL of the sample, pour it into the glass container for 30 s, and test with the poured-out sample.

[0079] 3. Thermal Stability Test: First, heat the glass dish in an oil bath for 5 min until the temperature reaches 220°C, then stop heating. Immediately take 2 mL of the atomized liquid samples obtained from the examples and comparative examples, pour it into the glass container for 30 s, and test with the poured-out sample. The test items include color, appearance, and sodium hyaluronate content.

[0080] Table 3 Test Results of the Stability of the Atomized Stock Solution Obtained from the Examples and Comparative Examples

[0081]

Claims

1. A highly stable whitening and anti-aging atomizing liquid, characterized in that, by weight parts The raw materials for its preparation include: by weight percentage: 0.05 - 1.5% of enzyme activity inhibitor, 0.15 - 8% of polysaccharide, 0.5 - 10% of calcium sodium phosphosilicate, 0.02 - 4% of skin conditioner, 0.1 - 0.5% of polypeptide, 1.5 - 13% of vitamin, 2 - 9% of edible essence, and polar solvent is added to 100%; The polysaccharide is sodium hyaluronate and proteoglycan; The sodium hyaluronate is oligomeric sodium hyaluronate; The mass ratio of the sodium hyaluronate to the proteoglycan is 1.65:0.5; The mass ratio of 1,2 - propanediol to glycerol is 2:1; The glycerol is hydrolyzed glycerol.

2. The highly stable whitening and anti-aging atomizing liquid according to claim 1, characterized in that, The enzyme activity inhibitor is selected from one or more of pomegranate fruit extract, yeast powder, sialic acid, red wine powder, epigallocatechin gallate, and niacinamide.

3. A highly stable whitening and anti-aging atomizing liquid according to claim 1 or 2, characterized in that, The enzyme activity inhibitor is sialic acid.

4. The highly stable whitening and anti-aging atomizing liquid according to claim 1, characterized in that, The polypeptide is selected from one or more of oligopeptide - 1, collagen peptide, elastin peptide, collagen tripeptide, acetyl octapeptide - 3, palmitoyl pentapeptide - 4, palmitoyl tripeptide - 1, tripeptide - 1 copper, acetyl octapeptide - 3, and palmitoyl tetrapeptide - 7.

5. The highly stable whitening and anti-aging atomizing liquid according to claim 4, characterized in that, The polypeptide is collagen tripeptide.

6. A method for preparing a highly stable whitening and anti-aging atomizing liquid according to any one of claims 1-5, characterized in that, It includes the following steps: (1) Add the enzyme activity inhibitor, polysaccharide, vitamin, and edible essence to the polar solvent and stir - mix to obtain a mixture; (2) Continuously add calcium sodium phosphosilicate, skin conditioner, and polypeptide to the mixture obtained in step (1) and continue stirring to obtain the product.

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