A nanoemulsion, its preparation method and application

Abstract

This invention discloses a nanoemulsion, its preparation method, and its application. By mass percentage, the nanoemulsion comprises the following components: 52.0%–78.5% glycerol, 20.0%–40.0% oil, and 1.5%–8.0% polyglycerol-10 stearate; wherein the oil is any one or a mixture of at least two of meadowfoam seed oil, jojoba seed oil, low-erucic acid rapeseed oil, olive fruit oil, and squalane. This invention prepares a 120nm nanoemulsion by high-pressure homogenization of the oil. Thus, by simply adding the nanoemulsion to water with stirring, it can achieve long-term stable dispersion in an aqueous system and is not prone to rancidity. This overcomes the limitations of conventional aqueous formulations in terms of component composition. High-pressure homogenization can be used to form nanoemulsions, enabling the development of more oil emulsions that can be stabilized in an aqueous system with simple stirring, thereby developing more stable aqueous spray products.

Description

TECHNICAL FIELD

[0001] The present application relates to the cosmetic technology field, and in particular to a nanoemulsion and a preparation method and application thereof. BACKGROUND

[0002] At present, the moisturizing water spray on the market usually only has water or water plus a water-phase moisturizing ingredient, which has the problem of poor moisturizing effect. Meanwhile, because the effective components are prone to sedimentation and stratification, the development of water-phase formula products is limited. SUMMARY

[0003] The present application aims to provide a nanoemulsion and a preparation method and application thereof, which are prepared by treating oil and fat by high-pressure homogenization, so as to obtain a nanoemulsion that can stably exist in a water-phase system and is not prone to rancidity, thereby solving the problems of insufficient stability and single raw material selection of the moisturizing water spray in the prior art.

[0004] In order to achieve the above-mentioned purpose, the present application adopts the following technical scheme:

[0005] In a first aspect, the present application provides a nanoemulsion, which is composed of the following components in terms of mass percentage: glycerol 52.0% to 78.5%, oil and fat 20.0% to 40.0%, and polyglyceryl-10 stearate 1.5% to 8.0%.

[0006] The oil and fat is any one or a mixture of at least two of white pool flower seed oil, jojoba seed oil, low erucic acid rapeseed oil, olive fruit oil, and squalane.

[0007] Further, the nanoemulsion is white pool flower seed oil nanoemulsion, jojoba seed oil nanoemulsion, olive fruit oil nanoemulsion, or squalane nanoemulsion.

[0008] In some specific technical solutions, the white pool flower seed oil nanoemulsion is composed of the following components in terms of mass percentage: glycerol 52.0% to 78.0%, white pool flower seed oil 20.0% to 40.0%, and polyglyceryl-10 stearate 2.0% to 8.0%.

[0009] In some specific technical solutions, the jojoba seed oil nanoemulsion is composed of the following components in terms of mass percentage: glycerol 52.2% to 78.2%, jojoba seed oil 20.0% to 40.0%, and polyglyceryl-10 stearate 1.8% to 7.8%.

[0010] In some specific technical solutions, the olive fruit oil nanoemulsion is composed of the following components in terms of mass percentage: glycerol 52.2% to 78.2%, olive fruit oil 20.0% to 40.0%, and polyglyceryl-10 stearate 1.8% to 7.8%.

[0011] In some specific technical solutions, the squalane nanoemulsion is composed of the following components in percentage by mass: glycerin 52.5% to 78.5%, squalane 20.0% to 40.0%, polyglyceryl-10 stearate 1.5% to 7.5%.

[0012] In a second aspect, the present application provides a preparation method of the above-mentioned nanoemulsion, comprising the following steps:

[0013] Step A: glycerin, oil, polyglyceryl-10 stearate are added to the emulsifying kettle, and the stirring speed is 100-200 RPM. The temperature is raised to 80℃, and then the stirring speed is kept to continue stirring for 15-20 min until the material is completely dissolved;

[0014] Step B: keep the temperature at 80℃, first homogenize at a speed of 2800-3000 RPM for 10-15 min, then slowly stir at a speed of 100-200 RPM for 10 min, homogenize again at a speed of 2800-3000 RPM for 10-15 min, then slowly stir at a speed of 100-200 RPM for 20-30 min, and finally cool to 35-40℃, and discharge;

[0015] Step C: the material obtained in step B is added to a high-pressure homogenizer, and the material is homogenized at least once at a pressure of 400-600 Bar, and the nanoemulsion is obtained.

[0016] In a third aspect, the present application provides the use of the above-mentioned nanoemulsion in water-spray products. Specifically, the added mass ratio of the nanoemulsion is 1.5% to 10%.

[0017] Further, the water-spray product is a moisturizing water spray. Specifically, it includes a moisturizing water spray, a moisturizing repair spray, a moisturizing essence water spray, a moisturizing repair mask essence liquid spray, and various specific product forms.

[0018] In some specific technical solutions, the moisturizing water spray is composed of the following components in percentage by mass: water 93% to 98%, white pool flower seed oil nanoemulsion 1.5% to 4%, centella asiatica leaf extract 0.2% to 1.0%, phenoxyethanol 0.1% to 0.8%, p-hydroxyacetophenone 0.1% to 0.8%, ethylhexylglycerin 0.01% to 0.4%.

[0019] In some specific technical solutions, the moisturizing water spray is composed of the following components in percentage by mass: water 86.8%, white pool flower seed oil nanoemulsion 3%, squalane nanoemulsion 3%, butylene glycol 4%, beta-glucan 2%, tremella polysaccharide 0.10%, sodium hyaluronate 0.10%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%.

[0020] In some specific technical solutions, the moisturizing water spray is composed of the following components in mass percentage: white birch juice 87.00%, white pool flower seed oil nanoemulsion 10%, dipropylene glycol 2%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%.

[0021] In some specific technical solutions, the moisturizing water spray is composed of the following components in mass percentage: water 90.60%, white pool flower seed oil nanoemulsion 2%, jojoba seed oil nanoemulsion 2%, olive fruit oil nanoemulsion 2%, squalane nanoemulsion 2%, 1,2-hexanediol 1%, phenoxyethanol 0.4%.

[0022] In some specific technical solutions, the moisturizing water spray is composed of the following components in mass percentage: water 89.70%, white pool flower seed oil nanoemulsion 3%, panthenol 2%, aloe barbadensis leaf juice 2%, butylene glycol 2%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%, xanthan gum 0.30%.

[0023] Raw material selection of the present application:

[0024] Glycerin is one of the most common moisturizers, which is cheap and has superior moisturizing effect, and has certain solubilizing effect as a solvent.

[0025] There are two reasons for choosing white pool flower (LIMNANTHES ALBA) seed oil: one is that white pool flower seed oil has high stability, and the other is that it has good moisturizing and repairing effect.

[0026] The trace components of white pool flower seed oil mainly include alpha-tocopherol, beta-tocopherol, gamma-tocopherol and phytosterol. Since it contains a large amount of long-chain fatty acids with antioxidant effect, it is one of the most stable vegetable oils in the world. In products containing a large amount of water, the rancidity speed of oil and fat will be accelerated, so it is necessary to use oil and fat with high stability.

[0027] The white pool flower seed oil contains more than 95% of C20-22 fatty acid formed triglyceride. Among them, the white pool flower seed oil contains 18% of docosadienoic acid C22:2. C22:2 belongs to Omega-6 family, Omega-6 is an essential fatty acid for human body, which can prevent skin dryness and water loss, and keep skin healthy. Generally, the plant oil contains more 16 and 18 carbon, and 20 and 22 carbon is long carbon chain. The long carbon chain structure and its unique chemical structure form beneficial ingredients after condensation, so that the white pool flower seed oil can improve dryness, promote skin repair and improve the ability of skin to resist external stimulation. The desquamating hormone contained in the white pool flower seed oil has the effects of preventing water loss and regenerating skin, and is a skin metabolism activator; it can change keratin tissue, regulate water and compound exudation, reabsorb water and form hydrate in epidermal layer cells, thereby locking water in the skin epidermis to achieve the effect of moisturizing.

[0028] Jojoba (SIMMONDSIA CHINENSIS) seed oil has high stability, good penetration, and high temperature resistance; it contains rich vitamin D and protein, is a good moisturizing and moisturizing oil, can maintain skin moisture, prevent wrinkles and soften skin, and is suitable for mature and aging skin.

[0029] Low erucic acid rapeseed oil is rapeseed oil with erucic acid content not more than 3% of fatty acid composition.

[0030] Olive (OLEA EUROPAEA) fruit oil has a moisturizing effect, is a natural emollient oil, and can deeply nourish the skin. The olive fruit oil contains rich unsaturated fatty acids and flavonoids, and some trace elements selenium, which can prevent oxidation reaction in the human body, thereby achieving the effect of delaying aging; the natural oil contained in the olive fruit oil has strong skin affinity, can effectively improve the dryness, roughness and discomfort of the skin, nourish tender skin and improve skin elasticity.

[0031] Squalane is an animal oil with high chemical stability and excellent use feeling, which has good affinity with skin, low polarity and moderate spreading property; it has high moisturizing and moisturizing properties, excellent antioxidant and thermal stability.

[0032] In addition, the stability of nanoemulsion in the formula is affected not only by the size of the emulsion droplets, but also by the formation of a rigid surfactant layer (combination of surfactants with appropriate HLB). The HLB value of polyglyceryl-10 stearate is 12.0-15.0, which can be dispersed in water, dissolved in organic solvents such as ethanol, resistant to acid, has excellent high temperature stability, can be used in a wide range of HLB, and has strong emulsifying ability; at the same time, it is a non-PEG & PPG emulsifier (beauty practice safety risk score is 1 green).

[0033] Compared with the prior art, the present application provides a nanoemulsion and a preparation method and application thereof, and has the following beneficial effects:

[0034] The present application makes the oil into 120nm nanoemulsion through high-pressure homogenization treatment, so that the nanoemulsion can be stably dispersed in the aqueous phase system for a long time by simple stirring, without oil separation and stratification and without easy rancidity, solves the problem that the components of the conventional aqueous phase formula are limited, and enables the components that can be added to the aqueous phase to be not limited to water-based components, but more oil emulsions can be developed by forming nanoemulsions through high-pressure homogenization, so that they can be stably added to the aqueous phase system by simple stirring, thereby developing more stable water-based spray products. BRIEF DESCRIPTION OF DRAWINGS

[0035] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor.

[0036] Figure 1 Comparison of transparency of white pool flower seed oil nanoemulsion prepared for Example 1-1, Example 1-2 and Example 1-3;

[0037] Figure 2 Comparison of transparency of jojoba seed oil nanoemulsion prepared for Example 2-1, Example 2-2 and Example 2-3;

[0038] Figure 3 Comparison of transparency of olive fruit oil nanoemulsion prepared for Example 3-1, Example 3-2 and Example 3-3;

[0039] Figure 4 Comparison of transparency of squalane nanoemulsion prepared for Example 4-1, Example 4-2 and Example 4-3;

[0040] Figure 5 Comparison of stability of different water-based spray products before and after testing;

[0041] Figure 6 Layering of water-based spray product prepared for Comparative Example 1-1 after standing;

[0042] Figure 7 Layering of water-based spray product prepared for Comparative Example 2-1 after standing. DETAILED DESCRIPTION

[0043] The technical solutions of the present application will be described clearly and completely below. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0044] The raw materials used in the present application can be purchased through commercial channels.

[0045] The present application will be described in further detail below through specific embodiments and in conjunction with the drawings.

[0046] Example 1-1

[0047] The white pool flower seed oil nanoemulsion provided in this embodiment consists of the following components by mass percentage: glycerol 78.0%, white pool flower seed oil 20.0%, and polyglyceryl-10 stearate 2.0%.

[0048] The preparation method of the white pool flower seed oil nanoemulsion includes the following steps:

[0049] Step A: Add glycerol, white pool flower seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir to warm up to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 15 min until the materials are completely dissolved;

[0050] Step B: Keep the temperature at 80℃, first homogenize quickly at a speed of 2900 RPM for 15 min, then stir slowly at a speed of 150 RPM for 10 min, homogenize again at a speed of 2900 RPM for 15 min, then stir slowly at a speed of 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0051] Step C: Add the material obtained in Step B into a high-pressure homogenizer, homogenize the material twice at a pressure of 500 Bar, and obtain the product.

[0052] Example 1-2

[0053] The white pool flower seed oil nanoemulsion provided in this embodiment consists of the following components by mass percentage: glycerol 66.0%, white pool flower seed oil 30.0%, and polyglyceryl-10 stearate 4.0%.

[0054] The preparation method of the white pool flower seed oil nanoemulsion includes the following steps:

[0055] Step A: Add glycerol, white pool flower seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir to warm up to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 15 min until the materials are completely dissolved;

[0056] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0057] Step C: add the material obtained in step B into a high-pressure homogenizer, homogenize the material once at a pressure of 500 Bar, and obtain the product.

[0058] Example 1-3

[0059] The white pool flower seed oil nanoemulsion provided by the example comprises, by mass percentage, glycerol 54.0%, white pool flower seed oil 40.0%, and polyglyceryl-10 stearate 6.0%.

[0060] The preparation method of the white pool flower seed oil nanoemulsion comprises the following steps:

[0061] Step A: add glycerol, white pool flower seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat to 80℃, and then continue to stir at the stirring speed for 20 min until the material is completely melted;

[0062] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 40℃, and discharge;

[0063] Step C: add the material obtained in step B into a high-pressure homogenizer, homogenize the material once at a pressure of 600 Bar, and obtain the product.

[0064] Example 2-1

[0065] The jojoba seed oil nanoemulsion provided by the example comprises, by mass percentage, glycerol 78.2%, jojoba seed oil 20.0%, and polyglyceryl-10 stearate 1.8%.

[0066] The preparation method of the jojoba seed oil nanoemulsion comprises the following steps:

[0067] Step A: add glycerol, jojoba seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat to 80℃, and then continue to stir at the stirring speed for 15 min until the material is completely melted;

[0068] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0069] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material twice at a pressure of 500 Bar, and obtain the product.

[0070] Example 2-2

[0071] The jojoba seed oil nanoemulsion provided in this example consists of the following components in percentage by mass: glycerin 66.0%, jojoba seed oil 30.0%, and polyglyceryl-10 stearate 4.0%.

[0072] The preparation method of the jojoba seed oil nanoemulsion includes the following steps:

[0073] Step A: add glycerin, jojoba seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat up to 80℃, then continue stirring at the same stirring speed for 15 min until the material is completely melted;

[0074] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0075] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material once at a pressure of 500 Bar, and obtain the product.

[0076] Example 2-3

[0077] The jojoba seed oil nanoemulsion provided in this example consists of the following components in percentage by mass: glycerin 54.0%, jojoba seed oil 40.0%, and polyglyceryl-10 stearate 6.0%.

[0078] The preparation method of the jojoba seed oil nanoemulsion includes the following steps:

[0079] Step A: add glycerin, jojoba seed oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat up to 80℃, then continue stirring at the same stirring speed for 20 min until the material is completely melted;

[0080] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 40℃, and discharge;

[0081] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material once at a pressure of 600 Bar, and obtain the product.

[0082] Example 3-1

[0083] The olive fruit oil nanoemulsion provided in this example consists of the following components in percentage by mass: glycerin 78.2%, olive fruit oil 20.0%, polyglyceryl-10 stearate 1.8%.

[0084] The preparation method of the olive fruit oil nanoemulsion includes the following steps:

[0085] Step A: add glycerin, olive fruit oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir to warm up to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 15 min until the material is completely dissolved;

[0086] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0087] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material twice at a pressure of 500 Bar, and obtain the product.

[0088] Example 3-2

[0089] The olive fruit oil nanoemulsion provided in this example consists of the following components in percentage by mass: glycerin 64.0%, olive fruit oil 32.0%, polyglyceryl-10 stearate 4.0%.

[0090] The preparation method of the olive fruit oil nanoemulsion includes the following steps:

[0091] Step A: add glycerin, olive fruit oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir to warm up to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 15 min until the material is completely dissolved;

[0092] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0093] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material once at a pressure of 500 Bar, and obtain the product.

[0094] Example 3-3

[0095] The olive fruit oil nanoemulsion provided in this example consists of the following components by mass percentage: glycerin 54.5%, olive fruit oil 40.0%, and polyglyceryl-10 stearate 5.5%.

[0096] The preparation method of the olive fruit oil nanoemulsion includes the following steps:

[0097] Step A: add glycerin, olive fruit oil, and polyglyceryl-10 stearate into an emulsifying kettle, stir to heat to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 20 min until the material is completely melted;

[0098] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 40℃, and discharge;

[0099] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material once at a pressure of 600 Bar, and obtain the product.

[0100] Example 4-1

[0101] The squalane nanoemulsion provided in this example consists of the following components by mass percentage: glycerin 78.5%, squalane 20.0%, and polyglyceryl-10 stearate 1.5%.

[0102] The preparation method of the squalane nanoemulsion includes the following steps:

[0103] Step A: add glycerin, squalane, and polyglyceryl-10 stearate into an emulsifying kettle, stir to heat to 80℃ at a stirring speed of 150 RPM, then continue stirring at the same stirring speed for 15 min until the material is completely melted;

[0104] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0105] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material twice at a pressure of 500 Bar, and obtain the squalane nanoemulsion.

[0106] Example 4-2

[0107] The squalane nanoemulsion provided in this example consists of the following components by mass percentage: glycerin 61.5%, squalane 35.0%, and polyglyceryl-10 stearate 3.5%.

[0108] The preparation method of the squalane nanoemulsion includes the following steps:

[0109] Step A: add glycerin, squalane, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat to 80℃, then continue stirring at the same stirring speed for 15 min until the material is completely melted;

[0110] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally cool down to 35℃, and discharge;

[0111] Step C: add the material obtained in Step B into a high-pressure homogenizer, homogenize the material once at a pressure of 500 Bar, and obtain the squalane nanoemulsion.

[0112] Example 4-3

[0113] The squalane nanoemulsion provided in this example consists of the following components by mass percentage: glycerin 54.5%, squalane 40.0%, and polyglyceryl-10 stearate 5.5%.

[0114] The preparation method of the squalane nanoemulsion includes the following steps:

[0115] Step A: add glycerin, squalane, and polyglyceryl-10 stearate into an emulsifying kettle, stir at a stirring speed of 150 RPM to heat to 80℃, then continue stirring at the same stirring speed for 20 min until the material is completely melted;

[0116] Step B: keep the temperature at 80℃, first homogenize at 2900 RPM for 15 min, then stir slowly at 150 RPM for 10 min, homogenize again at 2900 RPM for 15 min, then stir slowly at 150 RPM for 30 min, finally reduce the temperature to 40℃, and discharge;

[0117] Step C: add the material obtained in step B into a high-pressure homogenizer, and homogenize the material once at a pressure of 600 Bar, to obtain the product.

[0118] Application Example 1-1

[0119] The application example provides a water agent spray product, in particular, a moisturizing water spray, which is composed of the following components in mass percentage: water 96.3%, white pool flower seed oil nanoemulsion prepared in Example 1-2 2%, centella asiatica leaf extract 0.6%, phenoxyethanol 0.5%, p-hydroxyacetophenone 0.5%, and ethylhexylglycerin 0.1%.

[0120] The preparation method of the moisturizing water spray comprises the following steps:

[0121] Step A: add water into a blending cylinder, set the heating temperature of the blending cylinder to 90℃, start the stirring speed of the milk pan at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain 90-95℃ to add phenoxyethanol and p-hydroxyacetophenone, and stir for 20 min to completely dissolve the material;

[0122] Step B: set the cooling temperature of the blending cylinder to 30℃, reduce the stirring speed of the material temperature to below 50℃ at 20 RPM, and then add the white pool flower seed oil nanoemulsion prepared in Example 1-2, centella asiatica leaf extract, and ethylhexylglycerin in sequence, and stir for 15 min to obtain the product.

[0123] Application Example 1-2

[0124] The application example provides a water agent spray product, in particular, a moisturizing water spray, which is composed of the following components in mass percentage: water 96.3%, white pool flower seed oil nanoemulsion prepared in Example 1-2 2%, centella asiatica leaf extract 0.6%, phenoxyethanol 0.5%, p-hydroxyacetophenone 0.5%, and ethylhexylglycerin 0.1%.

[0125] The preparation method of the moisturizing water spray comprises the following steps:

[0126] Step A: add water into a blending cylinder, set the heating temperature of the blending cylinder to 90℃, start the stirring speed of the milk pan at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain 90-95℃ to add phenoxyethanol and p-hydroxyacetophenone, and stir for 20 min to completely dissolve the material;

[0127] Step B: Set the cooling temperature of the preparation cylinder to 30°C, and reduce the material temperature to below 50°C at a speed of 20 RPM. Then, sequentially add the white pool seed oil nanoemulsion prepared in Example 1-2, the Centella asiatica leaf extract, and the ethylhexylglycerin, and stir for 15 min.

[0128] Application Example 1-3

[0129] The present application example provides a water agent spray product, specifically a moisturizing water spray, which is composed of the following components in mass percentage: water 94.3%, white pool seed oil nanoemulsion prepared in Example 1-2 4%, Centella asiatica leaf extract 0.6%, phenoxyethanol 0.5%, p-hydroxyacetophenone 0.5%, and ethylhexylglycerin 0.1%.

[0130] The preparation method of the moisturizing water spray comprises the following steps:

[0131] Step A: Add water into the preparation cylinder, and set the heating temperature of the preparation cylinder to 90°C. Start the stirring speed of the milk pot at 15 RPM, and stop heating when the material temperature is heated to 90°C. Then, maintain the temperature between 90-95°C, and add phenoxyethanol and p-hydroxyacetophenone. Stir for 20 min to completely dissolve the materials.

[0132] Step B: Set the cooling temperature of the preparation cylinder to 30°C, and reduce the material temperature to below 50°C at a speed of 20 RPM. Then, sequentially add the white pool seed oil nanoemulsion prepared in Example 1-2, the Centella asiatica leaf extract, and the ethylhexylglycerin, and stir for 15 min.

[0133] Application Example 2

[0134] The present application example provides a water agent spray product, specifically a moisturizing and repairing spray, which is composed of the following components in mass percentage: water 86.8%, white pool seed oil nanoemulsion prepared in Example 1-2 3%, squalane nanoemulsion prepared in Example 4-2 3%, butanediol 4%, β-glucan 2%, tremella polysaccharide 0.1%, sodium hyaluronate 0.1%, p-hydroxyacetophenone 0.5%, and ethylhexylglycerin 0.5%.

[0135] The preparation method of the moisturizing and repairing spray comprises the following steps:

[0136] Step A: Pre-mix and disperse the tremella polysaccharide and sodium hyaluronate, and butanediol, and reserve;

[0137] Step B: Add water into the preparation cylinder, and set the heating temperature of the preparation cylinder to 90°C. Start the stirring speed of the milk pot at 15 RPM, and stop heating when the material temperature is heated to 90°C. Then, maintain the temperature between 90-95°C, and add p-hydroxyacetophenone and ethylhexylglycerin. Stir for 20 min to completely dissolve the materials.

[0138] Step C: Add previously mixed and dispersed completely tremella polysaccharide, sodium hyaluronate and butanediol, stir for 10 min;

[0139] Step D: Set the cooling temperature of the preparation cylinder to 30℃, maintain the stirring speed of the milk pot at 20 RPM, reduce the material temperature stirring to below 50℃, and sequentially add the white pool flower seed oil nanoemulsion prepared in Example 1-2, the squalane nanoemulsion prepared in Example 4-2, and β-glucan, stir for 15 min.

[0140] Application Example 3

[0141] The present application example provides a water agent spray product, specifically a high-efficiency moisturizing essence water spray, which is composed of the following components in mass percentage: birch juice 87.0%, white pool flower seed oil nanoemulsion prepared in Example 1-2 10.0%, dipropylene glycol 2.0%, p-hydroxyacetophenone 0.5%, and ethylhexylglycerin 0.5%.

[0142] The preparation method of the high-efficiency moisturizing essence water spray includes the following steps:

[0143] Step A: Add birch juice into the preparation cylinder, set the heating temperature of the preparation cylinder to 90℃, start the stirring speed of the milk pot at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain 90-95℃ to add p-hydroxyacetophenone and ethylhexylglycerin, and stir for 20 min to completely dissolve the material;

[0144] Step B: Set the cooling temperature of the preparation cylinder to 30℃, maintain the stirring speed of the milk pot at 20 RPM, reduce the material temperature stirring to below 50℃, and sequentially add the white pool flower seed oil nanoemulsion prepared in Example 1-2 and dipropylene glycol, stir for 15 min.

[0145] Application Example 4

[0146] The present application example provides a water agent spray product, specifically a moisturizing water spray containing multiple essence oils, which is composed of the following components in mass percentage: water 90.6%, white pool flower seed oil nanoemulsion prepared in Example 1-2 2.0%, jojoba seed oil nanoemulsion prepared in Example 2-2 2.0%, olive fruit oil nanoemulsion prepared in Example 3-2 2.0%, squalane nanoemulsion prepared in Example 4-2 2.0%, 1,2-hexanediol 1.0%, and phenoxyethanol 0.4%.

[0147] The preparation method of the moisturizing water spray containing multiple essence oils includes the following steps:

[0148] Step A: add water into the preparation cylinder, set the heating temperature of the preparation cylinder to 90℃, start the stirring speed of the milk pot at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain between 90-95℃, keep for 20 min, sterilize;

[0149] Step B: set the cooling temperature of the preparation cylinder to 30℃, maintain the stirring speed of the milk pot at 20 RPM, reduce the material temperature below 50℃, add the white pool flower seed oil nanoemulsion prepared in Example 1-2, the jojoba seed oil nanoemulsion prepared in Example 2-2, the olive fruit oil nanoemulsion prepared in Example 3-2, the squalane nanoemulsion prepared in Example 4-2, 1,2-hexanediol and phenoxyethanol in sequence, stir for 15 min, and obtain the product.

[0150] Application Example 5

[0151] The application example provides a water agent spray product, in particular a moisturizing repair mask essence spray, which is composed of the following components in mass percentage: water 89.7%, white pool flower seed oil nanoemulsion prepared in Example 1-2 3.0%, panthenol 2.0%, aloe vera leaf juice 2.0%, butanediol 2.0%, p-hydroxyacetophenone 0.5%, ethylhexylglycerin 0.5%, xanthan gum 0.3%.

[0152] The preparation method of the moisturizing repair mask essence spray comprises the following steps:

[0153] Step A: pre-mix and stir to disperse butanediol and xanthan gum, and reserve;

[0154] Step B: add water into the preparation cylinder, set the heating temperature of the preparation cylinder to 90℃, start the stirring speed of the milk pot at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain between 90-95℃, add p-hydroxyacetophenone and ethylhexylglycerin, keep stirring for 20 min to make the material completely dissolved;

[0155] Step C: add the pre-mixed and dispersed butanediol and xanthan gum, and stir for 10 min;

[0156] Step D: set the cooling temperature of the preparation cylinder to 30℃, maintain the stirring speed of the milk pot at 20 RPM, reduce the material temperature below 50℃, add the white pool flower seed oil nanoemulsion prepared in Example 1-2, panthenol and aloe vera leaf juice in sequence, stir for 15 min, and obtain the product.

[0157] Comparative Example 1-1

[0158] The present comparative example provides a water agent spray product, specifically a moisturizing water spray, which is composed of the following components in mass percentage: water 96.3%, glycerol 1.32%, white pool seed oil 0.6%, polyglyceryl-10 stearate 0.08%, centella asiatica leaf extract 0.6%, phenoxyethanol 0.5%, p-hydroxyacetophenone 0.5%, ethylhexylglycerin 0.1%.

[0159] The preparation method of the moisturizing water spray includes the following steps:

[0160] Step A: heat and stir white pool seed oil and polyglyceryl-10 stearate to dissolve, then add glycerol and stir evenly, and reserve;

[0161] Step B: add water to the preparation cylinder, set the heating temperature of the preparation cylinder to 90°C, and start the stirring speed of the milk pot at 15 RPM. When the material temperature is heated to 90°C, stop heating, then maintain 90-95°C, add phenoxyethanol and p-hydroxyacetophenone, and stir for 20 min to completely dissolve the material;

[0162] Step C: set the cooling temperature of the preparation cylinder to 30°C, reduce the stirring speed of the material temperature to below 50°C at 20 RPM, add centella asiatica leaf extract and ethylhexylglycerin in turn and stir evenly, start homogenization at 1900 RPM, slowly add the previously mixed white pool seed oil, polyglyceryl-10 stearate, and glycerol, homogenize for 2 min, then set the homogenization speed to 2900 RPM for rapid homogenization for 5 min, and obtain the product.

[0163] Comparative Example 2-1

[0164] The present comparative example provides a water agent spray product, specifically a moisturizing repair spray, which is composed of the following components in mass percentage: water 86.8%, white pool seed oil 1%, squalane 1%, polyglyceryl-10 stearate 1%, glycerol 3%, butanediol 4%, beta-glucan 2%, tremella polysaccharide 0.1%, sodium hyaluronate 0.1%, p-hydroxyacetophenone 0.5%, ethylhexylglycerin 0.5%.

[0165] The preparation method of the moisturizing repair spray includes the following steps:

[0166] Step A: heat and stir white pool seed oil, squalane, and polyglyceryl-10 stearate to dissolve, add glycerol and stir evenly, and reserve;

[0167] Step B: pre-mix and disperse tremella polysaccharide, sodium hyaluronate, and butanediol, and reserve;

[0168] Step C: add water into the preparation cylinder, set the heating temperature of the preparation cylinder to 90℃, start the stirring speed of the milk pot at 15 RPM, stop heating when the material temperature is heated to 90℃, then maintain 90-95℃, add p-hydroxyacetophenone, ethylhexyl glycerol, and maintain stirring for 20 min to completely dissolve the material;

[0169] Step D: add previously mixed and dispersed completely tremella polysaccharide, sodium hyaluronate and butanediol, and stir for 10 min;

[0170] Step E: set the cooling temperature of the preparation cylinder to 30℃, maintain the stirring speed of the milk pot at 20 RPM, reduce the material temperature to below 50℃, add β-glucan and stir evenly, start homogenization at 1900 RPM, slowly add the previously mixed and evenly distributed white pool flower seed oil, squalane, polyglyceryl-10 stearate, and glycerol, homogenize for 2 min, then set the homogenization speed to 2900 RPM for rapid homogenization for 5 min, and obtain the product.

[0171] Experimental test

[0172] I. Stability test of oil raw materials: white pool flower (LIMNANTHES ALBA) seed oil, jojoba (SIMMONDSIA CHINENSIS) seed oil, olive (OLEA EUROPAEA) fruit oil, squalane, canola oil, macadamia (MACADAMIA TERNIFOLIA) seed oil, sunflower (HELIANTHUS ANNUUS) seed oil, grape (VITIS VINIFERA) seed oil, and camellia (CAMELLIA OLEIFERA) seed oil were tested for rancidity time at 130℃, and the oil with better stability was selected. The stability test results of the oil are shown in Table 1.

[0173] Table 1 Stability of different oils at 130℃

[0174]

[0175]

[0176] From Table 1, it can be seen that white pool flower seed oil, jojoba seed oil, olive fruit oil, squalane, and canola oil have good stability, among which white pool flower seed oil has the best stability.

[0177] II. Transparency comparison of nanoemulsions: The appearance transparency of the nanoemulsions of Bai Chi flower seed oil (prepared in Example 1-1, Example 1-2 and Example 1-3), jojoba seed oil (prepared in Example 2-1, Example 2-2 and Example 2-3), olive fruit oil (prepared in Example 3-1, Example 3-2 and Example 3-3), and squalane (prepared in Example 4-1, Example 4-2 and Example 4-3) with different oil contents were compared, and the results are shown in Table 1 and FIG. 1. Figures 1-4

[0178] As can be seen from Table 1 and FIG. 1, when containing 30% Bai Chi flower seed oil (corresponding to the middle plastic bottle sample), the transparency of the prepared Bai Chi flower seed oil nanoemulsion was higher; as can be seen from Table 1 and FIG. 1, when containing 30% jojoba seed oil (corresponding to the middle plastic bottle sample), the transparency of the prepared jojoba seed oil nanoemulsion was higher; as can be seen from Table 1 and FIG. 1, when containing 32% olive fruit oil (corresponding to the middle plastic bottle sample), the transparency of the prepared olive fruit oil nanoemulsion was higher; as can be seen from Table 1 and FIG. 1, when containing 35% squalane (corresponding to the middle plastic bottle sample), the transparency of the prepared squalane nanoemulsion was higher. Figure 1 Figure 1 Figure 2 Figure 2 Figure 3 Figure 3 Figure 4 Figure 4

[0179] III. Stability test of water-based spray products:

[0180] Test objects: The water-based spray products prepared in Application Example 1-1, Application Example 1-2, Application Example 1-3, Application Example 2, Application Example 3, Application Example 4, Application Example 5, Comparative Example 1-1 and Comparative Example 2-1. Package state: stored in 150 g plastic bottles.

[0181] Test method: heat resistance, placed in a constant temperature and humidity box (48°C) for 3 months; cold resistance, placed in a refrigerator at 0-5°C for 3 months; room temperature for 3 months. After the end, the appearance was observed, and the results are shown in Table 2 and FIG. 2. Figure 5

[0182] Table 2 Stability of water-based spray products

[0183]

[0184] As can be seen from Table 2 and FIG. 2, the water-based spray products prepared in Application Example 1-1, Application Example 1-2, Application Example 1-3, Application Example 2, Application Example 3, Application Example 4 and Application Example 5 had good stability, and the products prepared in Comparative Example 1-1 and Comparative Example 2-1 had poor stability. Figure 5 ​​​​​​​​​​It can be seen that the water-based spray products prepared in application example 1-1, application example 1-2, application example 1-3, application example 2, application example 3, application example 4 and application example 5 are uniform milky white translucent liquids with slight characteristic odor and no visible insoluble particles after the stability test of heat resistance, cold resistance and room temperature for 3 months, and are uniform and not stratified.

[0185] Compared with application example 1-1, the white pool flower seed oil, glycerol and polyglyceryl-10 stearate in comparative example 1-1 are not subjected to high-pressure homogenization treatment, and the oil is prone to stratification after being added to the water-based spray product formula, as shown in Figure 6 , it becomes stratified after only a few hours of standing.

[0186] Compared with application example 2, the white pool flower seed oil, squalane, glycerol and polyglyceryl-10 stearate in comparative example 2-1 are not subjected to high-pressure homogenization treatment, and the oil is prone to stratification after being added to the water-based spray product formula, as shown in Figure 7 , stratification and oil separation occur after 24 h of standing, and the material needs to be shaken to mix evenly before use.

[0187] It can be seen that the oil is subjected to high-pressure homogenization treatment before being added to the water-based spray product formula, and the stability is significantly improved compared with the oil that is not subjected to high-pressure homogenization treatment; and the oil subjected to high-pressure homogenization treatment can be stably added to the water-based spray product by simple stirring, without the need for heating, adding emulsifiers and other operation treatments.

[0188] The above only describes the preferred embodiments of the present application and is not intended to limit the present application, and any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

[0189] In addition, it should be understood that although the present specification is described in terms of embodiments, not every embodiment contains only one independent technical solution, and the description manner of the specification is only for the sake of clarity, and the skilled person in the art should consider the specification as a whole, and the technical solutions in each embodiment can be combined to form other embodiments that can be understood by the skilled person.

Claims

1. A nanoemulsion characterized in that, consists of the following components by mass percentage: Glycerin 52.0%~78.5%, Oil 20.0%~40.0%, Polyglyceryl-10 Stearate 1.5%~8.0%; The oil is any one or mixture of at least two of white pool rapeseed oil, jojoba seed oil, olea europaea fruit oil, and squalane; The preparation method of the nanoemulsion comprises the following steps: Step A: Glycerin, oil, and polyglyceryl-10 stearate are added to an emulsifying kettle, and the material is stirred at a stirring speed of 100~200 RPM to be heated to 80℃, and then the stirring speed is kept to continue stirring for 15~20 min until the material is completely dissolved; Step B: The temperature is kept at 80℃, first homogenized at a speed of 2800~3000 RPM for 10~15 min, then slowly stirred at a speed of 100~200 RPM for 10 min, again homogenized at a speed of 2800~3000 RPM for 10~15 min, then slowly stirred at a speed of 100~200 RPM for 20~30 min, and finally cooled to 35~40℃, and discharged; Step C: The material obtained in step B is added to a high-pressure homogenizer, and the material is homogenized at a pressure of 400~600 Bar for at least one pass, and the nanoemulsion is obtained.

2. The nanoemulsion of claim 1, wherein, The nanoemulsion is white pool rapeseed oil nanoemulsion, jojoba seed oil nanoemulsion, olea europaea fruit oil nanoemulsion, or squalane nanoemulsion; The white pool rapeseed oil nanoemulsion consists of the following components by mass percentage: Glycerin 52.0%~78.0%, White pool rapeseed oil 20.0%~40.0%, Polyglyceryl-10 Stearate 2.0%~8.0%; The jojoba seed oil nanoemulsion consists of the following components by mass percentage: Glycerin 52.2%~78.2%, Jojoba seed oil 20.0%~40.0%, Polyglyceryl-10 Stearate 1.8%~7.8%; The olea europaea fruit oil nanoemulsion consists of the following components by mass percentage: Glycerin 52.2%~78.2%, Olea europaea fruit oil 20.0%~40.0%, Polyglyceryl-10 Stearate 1.8%~7.8%; The squalane nanoemulsion consists of the following components by mass percentage: Glycerin 52.5%~78.5%, Squalane 20.0%~40.0%, Polyglyceryl-10 Stearate 1.5%~7.5%.

3. Use of the nanoemulsion according to claim 2 for the preparation of a moisturizing lotion spray product, characterized in that, The added mass ratio of the nanoemulsion is 1.5%~10%.

4. Use according to claim 3, characterized in that, The water agent spray product is a moisturizing water spray.

5. Use according to claim 4, characterized in that, The moisturizing water spray consists of the following components by mass percentage: Water 93%~98%, The white pool rapeseed oil nanoemulsion of claim 2 1.5%~4%, Centella asiatica leaf extract 0.2%~1.0%, Phenoxyethanol 0.1%~0.8%, p-Hydroxyacetophenone 0.1%~0.8%, Ethylhexylglycerin 0.01%~0.4%; Alternatively, the moisturizing water spray consists of the following components by mass percentage: Water 86.8%, The white pool rapeseed oil nanoemulsion of claim 2 3%, The squalane nanoemulsion of claim 2 3%, Butylene glycol 4%, beta-glucan 2%, tremella polysaccharide 0.10%, sodium hyaluronate 0.10%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%; Alternatively, the moisturizing water spray consists of the following components in mass percentage: birch sap 87.00%, white pool flower seed oil nanoemulsion of claim 2 10%, dipropylene glycol 2%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%; Alternatively, the moisturizing water spray consists of the following components in mass percentage: water 90.60%, white pool flower seed oil nanoemulsion of claim 2 2%, jojoba seed oil nanoemulsion of claim 2 2%, olive fruit oil nanoemulsion of claim 2 2%, squalane nanoemulsion of claim 2 2%, 1,2-hexanediol 1%, phenoxyethanol 0.4%; Alternatively, the moisturizing water spray consists of the following components in mass percentage: water 89.70%, white pool flower seed oil nanoemulsion of claim 2 3%, panthenol 2%, aloe barbadensis leaf juice 2%, butylene glycol 2%, p-hydroxyacetophenone 0.50%, ethylhexylglycerin 0.50%, xanthan gum 0.30%.

Images