Stable kasugamycin soluble powder pesticide fertilizer and preparation method and application thereof

Abstract

The present application relates to a kind of stable kasugamycin soluble powder pesticide fertilizer and its preparation method and application.The soluble powder pesticide fertilizer, solid kasugamycin phosphate 0.05-0.5%, acid-base buffer 5-20%, monoammonium phosphate 5-20%, diammonium phosphate 5-20%, potassium dihydrogen phosphate 0.5-5%, potassium nitrate 10-30%, urea 5-20%, white carbon black 1-3%, and filling material makes up 100%.The present application first uses phosphoric acid solution and kasugamycin to form kasugamycin phosphate, then adds stabilizer and pH regulator, further promotes the combination of phosphate and kasugamycin, reduces the hydrolysis of kasugamycin phosphate.Adding slightly acidic potassium dihydrogen phosphate at the same time enhances the disease prevention effect of kasugamycin, and applying water and fertilizer integration realizes efficient disease prevention, efficient nutrition, and the purpose of saving labor and high efficiency.

Description

Technical Field

[0001] The invention relates to a stable kasugamycin soluble powder fertilizer and a preparation method and application thereof, belonging to the technical field of agricultural fertilizers. Background Art

[0002] Kasugamycin, also known as kasugamycin, is fermented by Streptomyces aureus. It is a weakly alkaline, water-soluble bioantibiotic. It is stable in slightly acidic environments but readily decomposes in strong acid or alkaline solutions. Therefore, during production and fermentation, it is typically produced as kasugamycin hydrochloride, which maintains a relatively stable pH range of 4 to 6. Kasugamycin is an excellent preventative and control agent for fungal and bacterial diseases and is widely used in various crops, such as rice and greenhouse vegetables.

[0003] Since its development, kasugamycin has been widely used worldwide for agricultural disease control, with particular effectiveness against rice blast. Furthermore, it is also widely used on crops such as potatoes, cucumbers, tomatoes, celery, peppers, and citrus. Foliar application effectively controls various bacterial and some fungal diseases. Because kasugamycin is fermented by microorganisms, it is residue-free and pollution-free, meeting modern environmental standards. It has been recommended by the China Green Food Development Center as an AA-level green food production material and listed by the Ministry of Agriculture as a recommended pesticide for pollution-free agricultural product production. With the widespread use of chemical pesticides and increased public awareness of pesticide safety, kasugamycin's high efficacy, broad spectrum, and harmless biological properties present an increasingly broad market prospect.

[0004] Kasugamycin is generally applied as a foliar spray in agriculture, reaching target areas through systemic absorption. For soil-borne diseases such as tomato wilt, foliar spraying is less effective because the disease occurs in the rhizomes. In these cases, flushing can be used. Solid water-soluble fertilizers are playing an increasingly important role in modern agricultural cultivation and are crucial in the current integrated water and fertilizer system. Root fertilization allows for rapid absorption by the rhizomes. Combining kasugamycin with solid water-soluble fertilizers can achieve the desired disease prevention and nutrition benefits, creating a water-pesticide-fertilizer integration that significantly saves manpower and resources and improves production efficiency.

[0005] Kasugamycin is stable only within a certain pH range. Therefore, it is often combined with hydrochloric acid in production to form kasugamycin hydrochloride. According to the "Regulations of the People's Republic of China on the Administration of Precursor Chemicals," hydrochloric acid is a precursor chemical and is subject to strict controls and restrictions in production and use. Furthermore, hydrochloric acid contains chloride ions, and most cash crops are relatively sensitive to chloride. High-volume, frequent use may have negative impacts on crops. The stability of this compound requires a better alternative to hydrochloric acid. Kasugamycin is also being combined with solid water-soluble fertilizers to create a new category of medicated fertilizers. Ensuring the stability of kasugamycin when mixed with various high-salt substances, such as nitrogen, phosphorus, and potassium, is also a new research topic.

[0006] Potassium phosphite, as a new type of integrated drug-fertilizer compound, not only provides high phosphorus and potassium, but also has excellent disease prevention effects. Potassium dihydrogen phosphite is a slightly acidic substance and is suitable for mixing with pesticides. When used in combination with kasugamycin, it has a different mechanism of action and a wider spectrum of prevention and control. There have been no reports on the mixing of kasugamycin and simple potassium dihydrogen phosphite.

[0007] Chinese patent literature CN114014722A discloses a kind of kasugamycin water-soluble fertilizer and preparation method thereof, utilizes resin to absorb kasugamycin after waste liquid to prepare water-soluble fertilizer, to maintain the stability of kasugamycin in fertilizer solution, adopts acid-base regulator, pH is adjusted to 5.0~6.0.But in the preparation method of this patent, liquid is spray-dried, and solid kasugamycin-containing water-soluble fertilizer is obtained, now through spray drying process, it is not possible to ensure that the pH of finished product is still at 5.0~6.0, simultaneously through 30~70 ℃ of temperature stirring, high temperature may also cause kasugamycin to decompose, this preparation process can not ensure whether kasugamycin is also stable in process and finished product, because what uses is kasugamycin waste liquid, whether the kasugamycin content of each batch is the same, whether the content of kasugamycin is enough to achieve the effect of disease prevention also exists unknown. Summary of the Invention

[0008] In response to the shortcomings of the prior art, the present invention aims to provide a stable kasugamycin soluble powder fertilizer, its preparation method, and its application. The fertilizer provided by the present invention has the advantages of acid and alkali resistance, constant pH, and high salt tolerance. At the same time, it can achieve the effects of high efficiency in preventing soil-borne diseases and high nutritional value through a single application. It solves the problems of kasugamycin stability and practical application, and realizes the integration of water, fertilizer, and pesticide.

[0009] The technical solutions of the present invention are as follows:

[0010] The invention discloses a stable kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.05-0.5% solid kasugamycin phosphate, 5-20% acid-base buffer, 5-20% monoammonium phosphate, 5-20% diammonium phosphate, 0.5-5% potassium dihydrogen phosphite, 10-30% potassium nitrate, 5-20% urea, 1-3% white carbon black, and fillers making up 100%.

[0011] Further preferably, the stable kasugamycin soluble powder fertilizer is composed of the following components in weight percentage: 0.1-0.3% solid kasugamycin phosphate, 5-10% acid-base buffer, 10-15% monoammonium phosphate, 10-15% diammonium phosphate, 3-5% potassium dihydrogen phosphite, 20-25% potassium nitrate, 10-15% urea, 1-2% white carbon black, and filler making up 100%.

[0012] According to the present invention, the solid kasugamycin phosphate is preferably prepared according to the following method:

[0013] First, add the kasugamycin fermentation liquid into the reactor, then add the phosphoric acid solution and the stabilizer, and stir at a constant temperature of 35-45°C for 25-35 minutes. Finally, add the pH adjuster, continue stirring at a constant temperature for 8-12 minutes, and spray dry to obtain solid kasugamycin phosphate.

[0014] The stabilizer is one or a mixture of two or more of fatty acid soap, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, polyoxyethylene ether, polyoxypropylene ether, ethylene oxide and propylene oxide block copolymer, polyol fatty acid ester and polyvinyl alcohol;

[0015] The pH regulator is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate;

[0016] The mass ratio of the kasugamycin fermentation broth, the phosphoric acid solution, the stabilizer and the pH regulator is (20-50):(1-3):(1-3):(10-30).

[0017] Further preferably, the concentration of the kasugamycin fermentation broth is 10-20 g / L; the concentration of the phosphoric acid solution is 80-90%; the pH regulator is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of (1-3):1; the mass ratio of the kasugamycin fermentation broth, phosphoric acid solution, stabilizer and pH regulator is (25-35):(1.5-2.5):(1.5-2.5):(15-25).

[0018] Most preferably, the concentration of the kasugamycin fermentation broth is 15-18 g / L; the concentration of the phosphoric acid solution is 85%; the pH adjuster is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of 2:1; the mass ratio of the kasugamycin fermentation broth, phosphoric acid solution, stabilizer and pH adjuster is 30:2:2:20.

[0019] Preferably, according to the present invention, the acid-base buffer is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate, and the mass ratio of the two is (1-3):1.

[0020] Further preferably, the mass ratio of the potassium dihydrogen phosphate to dipotassium hydrogen phosphate is 2:1.

[0021] According to the present invention, the filler is preferably one or a mixture of two or more of sodium sulfate, magnesium sulfate and calcium lignin sulfonate.

[0022] The present invention also provides a method for preparing the above-mentioned stable kasugamycin soluble powder fertilizer, comprising the following steps:

[0023] (1) crushing and adsorbing solid kasugamycin phosphate and white carbon black together to obtain kasugamycin powder;

[0024] (2) grinding the acid-base buffer, monoammonium phosphate, diammonium phosphate, potassium nitrate, potassium dihydrogen phosphite, urea, and filler into powders respectively, and then mixing them uniformly to obtain nutrient element powders;

[0025] (3) Kasugamycin powder and nutrient element powder are mixed in a fluidized bed airflow, and dried at a constant temperature of 60 to 80° C. for 25 to 35 minutes to obtain a stable kasugamycin soluble powder fertilizer.

[0026] Preferably, according to the present invention, in step (1), the particle size of the kasugamycin powder is less than or equal to 30 μm.

[0027] The kasugamycin soluble powder fertilizer of the present invention is used in increasing crop yield and preventing and controlling diseases. The method of use is flushing, drip irrigation or spraying, and the single dosage per mu is 3-6 kg.

[0028] More preferably, the crop is eggplant.

[0029] The present invention has the beneficial effects:

[0030] 1. The present invention has adopted phosphoric acid solution to be combined with kasugamycin for the first time, has formed kasugamycin phosphate, and has kept the pH of kasugamycin stable.Then a stabilizer is particularly added, utilizing the hydrophilicity and hydrophobicity of the stabilizer so that kasugamycin and phosphoric acid are combined more tightly, forming a barrier between kasugamycin phosphate and the aqueous solution, further reducing the hydrolysis of kasugamycin phosphate.Finally, a pH adjusting agent is added while stabilizing pH value, a large amount of phosphate ions are provided, further promoting the combination of phosphate radical and kasugamycin, and after reactant is dried to obtain solid-state kasugamycin phosphate, the pH adjusting agent can still continue to play the effect of stabilizing pH.

[0031] 2. Compared with the commonly used kasugamycin hydrochloride, the solid kasugamycin phosphate provided by the present invention is relatively easier to obtain, is not subject to the jurisdiction of precursor chemicals, and does not contain chloride ions, thus avoiding the side effects of improper application on crops. At the same time, phosphoric acid, as a nutrient element, can provide phosphorus, which has the effect of promoting flowering and root growth.

[0032] 3. The stable kasugamycin soluble powder fertilizer provided by the present invention utilizes white carbon black to adsorb solid kasugamycin phosphate during the final mixing process, thereby blocking the contact area between kasugamycin and high-salt fertilizers such as nitrogen, phosphorus, and potassium. At the same time, an acid-base buffer is applied to maintain the pH stability of the diluted solution when the finished product is dissolved, thereby ensuring that kasugamycin always maintains stability during actual use. At the same time, the acid-base buffer also provides phosphorus and potassium nutrients, which have the function of promoting crop growth.

[0033] 4. The stable kasugamycin soluble powder fertilizer provided by the present invention adds skewed potassium dihydrogen phosphite, which enhances the disease prevention effect of kasugamycin and uses integrated water and fertilizer to achieve the goals of efficient disease prevention, efficient nutrition, labor saving and high efficiency. DETAILED DESCRIPTION

[0034] The present invention will be further described below in conjunction with specific examples, but the present invention is not limited to these specific embodiments. Those skilled in the art will recognize that the present invention encompasses all alternatives, improvements, and equivalents that may be included within the scope of the claims. Each material in the embodiments of the present invention is commercially available. In all of the following examples, the percentages in the Chinese medicinal fertilizer ratios are all weight percentages.

[0035] Example 1

[0036] The invention discloses a stable kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% acid-base buffer, 5% monoammonium phosphate, 10% diammonium phosphate, 5% potassium dihydrogen phosphite, 20% potassium nitrate, 20% urea, 1% white carbon black, and 100% sodium sulfate.

[0037] The solid kasugamycin phosphate is prepared by the following method:

[0038] First, the kasugamycin fermentation liquor with a concentration of 15 g / L is put into a reaction kettle, then a phosphoric acid solution with a concentration of 85% and sodium dodecyl benzene sulfonate are put in, while stirring at a constant temperature of 40℃ for 30 min, finally the pH regulator is put in, and continue to stir at a constant temperature for 10 min, to obtain a stable kasugamycin phosphate liquid, with a pH of 4.5-5.5, which is spray dried to obtain the solid kasugamycin phosphate.

[0039] The pH regulator is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate with a mass ratio of 2:1.

[0040] The mass ratio of the kasugamycin fermentation liquor, the phosphoric acid solution, the stabilizer and the pH regulator is 30:2:2:20.

[0041] The acid-base buffer is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate with a mass ratio of 2:1.

[0042] The preparation method of the stable kasugamycin soluble powder fertilizer medicine comprises the following steps:

[0043] (1) The solid kasugamycin phosphate and white carbon black are ground and adsorbed together to obtain kasugamycin medicine powder, and the particle size of the obtained kasugamycin medicine powder is 15 μm.

[0044] (2) The acid-base buffer, monammonium phosphate, diammonium phosphate, potassium nitrate, potassium dihydrogen phosphite, urea and filler are respectively ground into powder, then mixed uniformly to obtain a nutrient element powder.

[0045] (3) The kasugamycin medicine powder and the nutrient element powder are mixed by fluidized bed airflow, and dried at a constant temperature of 70℃ for 30 min to obtain the stable kasugamycin soluble powder fertilizer medicine.

[0046] Example 2

[0047] A stable kasugamycin soluble powder fertilizer medicine, which is composed of the following components with the following weight percentage: 0.2% of solid kasugamycin phosphate, 8% of acid-base buffer, 10% of monammonium phosphate, 15% of diammonium phosphate, 3% of potassium dihydrogen phosphite, 10% of potassium nitrate, 15% of urea, 2% of white carbon black, and magnesium sulfate to make up 100%.

[0048] The preparation method of the solid kasugamycin phosphate is the same as that in Example 1, except that the concentration of the kasugamycin fermentation liquor is 16 g / L, the stabilizer is sodium dodecyl sulfate, and the mass ratio of the kasugamycin fermentation liquor, the phosphoric acid solution, the stabilizer and the pH regulator is 20:2:2:25.

[0049] The preparation method of the stable kasugamycin soluble powder fertilizer described in this embodiment is the same as that in Example 1.

[0050] Example 3

[0051] The invention discloses a stable kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.3% solid kasugamycin phosphate, 10% acid-base buffer, 15% monoammonium phosphate, 15% diammonium phosphate, 5% potassium dihydrogen phosphite, 20% potassium nitrate, 10% urea, 2% white carbon black, and 100% calcium lignin sulfonate.

[0052] The preparation method of the solid kasugamycin phosphate is the same as that of Example 1, except that the concentration of the kasugamycin fermentation broth is 18 g / L, the stabilizer is polyoxyethylene ether, and the mass ratio of the kasugamycin fermentation broth, phosphoric acid solution, stabilizer and pH regulator is 20:2:2:25.

[0053] The preparation method of the stable kasugamycin soluble powder fertilizer described in this embodiment is the same as that in Example 1.

[0054] Comparative Example 1

[0055] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% monoammonium phosphate, 10% diammonium phosphate, 5% potassium dihydrogen phosphite, 20% potassium nitrate, 20% urea, 1% white carbon black, and 100% sodium sulfate.

[0056] The solid-state kasugamycin phosphate is prepared according to the following method:

[0057] First, 15g / L kasugamycin fermentation liquid was added to the reactor, and then 85% phosphoric acid solution and sodium dodecylbenzenesulfonate were added. The mixture was stirred at a constant temperature of 40°C for 30 minutes. After spray drying, solid kasugamycin phosphate was obtained.

[0058] The mass ratio of the kasugamycin fermentation broth, the phosphoric acid solution and the stabilizer is 30:2:2.

[0059] The rest is the same as Example 1. Compared with Example 1, this comparative example does not contain an acid-base buffer, and no pH regulator is added during the preparation of the solid kasugamycin phosphate.

[0060] Comparative Example 2

[0061] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% acid-base buffer, 5% monoammonium phosphate, 10% diammonium phosphate, 5% potassium dihydrogen phosphite, 20% potassium nitrate, 20% urea, and 100% sodium sulfate.

[0062] The rest is the same as Example 1, except that this comparative example does not contain white carbon black compared with Example 1.

[0063] Comparative Example 3

[0064] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% acid-base buffer, 5% monoammonium phosphate, 10% diammonium phosphate, 20% potassium nitrate, 20% urea, 1% white carbon black, and 100% sodium sulfate.

[0065] The rest is the same as Example 1, except that this comparative example does not contain potassium dihydrogen phosphite compared with Example 1.

[0066] Comparative Example 4

[0067] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% acid-base buffer, 5% monoammonium phosphate, 10% diammonium phosphate, 20% potassium nitrate, 20% urea, 1% white carbon black, and 100% sodium sulfate.

[0068] The solid-state kasugamycin phosphate is prepared according to the following method:

[0069] First, a 15g / L kasugamycin fermentation liquid is added to a reactor, and then a phosphoric acid solution with a concentration of 85% is added. The mixture is stirred at a constant temperature of 40°C for 30 minutes. Finally, a pH regulator is added and the mixture is stirred at a constant temperature for 10 minutes to obtain a stable kasugamycin phosphate liquid with a pH stable at 4.5-5.5. After spray drying, solid kasugamycin phosphate is obtained.

[0070] The mass ratio of the kasugamycin fermentation broth, the phosphoric acid solution and the pH regulator is 30:2:20.

[0071] The rest is the same as Example 1. In this comparative example, the stabilizer sodium dodecylbenzenesulfonate is not added during the preparation of the solid kasugamycin phosphate.

[0072] Comparative Example 5

[0073] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% solid kasugamycin phosphate, 5% monoammonium phosphate, 10% diammonium phosphate, 20% potassium nitrate, 20% urea, 1% white carbon black, and 100% sodium sulfate.

[0074] The rest is the same as Example 1. Compared with Example 1, this comparative example does not contain an acid-base buffer, and only uses a pH regulator in the preparation of kasugamycin phosphate.

[0075] Comparative Example 6

[0076] The invention discloses a kasugamycin soluble powder fertilizer, which is composed of the following components in percentage by weight: 0.1% kasugamycin hydrochloride, 5% acid-base buffer, 5% monoammonium phosphate, 10% diammonium phosphate, 5% potassium dihydrogen phosphite, 20% potassium nitrate, 20% urea, 1% white carbon black, and fillers making up to 100%.

[0077] Compared with Example 1, this comparative example directly used commercially available kasugamycin hydrochloride technical instead of solid kasugamycin phosphate.

[0078] Test Example 1: Thermal Storage Stability Test

[0079] The fertilizers prepared in Example 1 and Comparative Examples 1 to 5 were tested for stability according to the method in GB / T 19136-2003. The specific method was as follows: the sample was placed in a wide-mouth bottle, sealed, and placed in a thermostat at 54±2°C. After 14 days of heat storage, the sample was removed and analyzed for the active ingredient, kasugamycin. The decomposition rate of kasugamycin was calculated based on the comparison of the detected content of the active ingredient kasugamycin at room temperature and after heat storage. The results are shown in Table 1.

[0080] Table 1

[0081]

[0082] As can be seen from Table 1, the untreated kasugamycin fermentation broth had a thermal decomposition rate of up to 98.12%, essentially inactivating it. Comparative Example 1, which did not contain an acid-base buffer, had a thermal decomposition rate of 25.33%, indicating that a stable pH value significantly affects kasugamycin. As the environment, such as high temperature, changes, the pH of the formulation itself may also change, causing kasugamycin to decompose. Comparative Example 2, which did not contain white carbon for adsorption, had a thermal decomposition rate of 10.45%, indicating that large-scale contact of kasugamycin with high salts such as nitrogen, phosphorus, and potassium can also cause instability and fail to meet the requirements of practical applications. Comparative Example 4, which did not contain a stabilizer, had a thermal decomposition rate of 11.56%, indicating that the stabilizer played a significant catalytic and protective role during the reaction of kasugamycin with phosphoric acid. Comparative Example 5, which only used an acid-base buffer during the phosphate production process of kasugamycin, had a thermal decomposition rate of 15.67%, indicating that in the finished formulation system, the pH value of the entire fertilizer has a significant impact on kasugamycin. Simply ensuring a stable pH value for kasugamycin is insufficient; contact with high salts such as nitrogen, phosphorus, and potassium can still cause unstable decomposition. Comparative Example 6 uses commercially available kasugamycin hydrochloride as a raw material. During its preparation process, it is generally simply acidified with hydrochloric acid. The thermal storage decomposition rate is 25.42%, indicating that the combination of kasugamycin and hydrochloric acid is not very stable. Direct application of kasugamycin hydrochloride to prepare medicated fertilizer cannot solve the problem of easy decomposition of kasugamycin itself and unstable decomposition caused by contact with high salts such as nitrogen, phosphorus and potassium.

[0083] The present invention has adopted phosphoric acid solution to combine with kasugamycin for the first time, formed kasugamycin phosphate, and kept kasugamycin pH stable. Then a stabilizer was added in particular, and the hydrophilic and hydrophobic properties of the stabilizer were utilized so that kasugamycin and phosphoric acid were combined more tightly, forming a barrier between kasugamycin phosphate and the aqueous solution, further reducing the hydrolysis of kasugamycin phosphate, and in the final mixing process, solid-state kasugamycin phosphate was adsorbed using white carbon black to block the contact area of ​​high-salt fertilizers such as kasugamycin and nitrogen, phosphorus and potassium, and an acid-base buffer was applied to make its finished product dissolve when it was dissolved, maintaining the pH stability of the solution after dilution, so that the stable kasugamycin soluble powder fertilizer heat storage decomposition rate provided in Example 1 was only 2.12%, much lower than Comparative Examples 1 to 2 and Comparative Examples 4 to 6.

[0084] Test Example 2: Efficacy of stable kasugamycin soluble powder fertilizer against eggplant wilt

[0085] Experimental location: Lanling Town, Lanling County, Linyi City, Shandong Province;

[0086] Experimental agents: 15 g / L kasugamycin fermentation stock solution (self-produced), the medicated fertilizer prepared in Example 1 and Comparative Examples 1 to 6, 2% kasugamycin aqueous solution (commercially available), and clean water as a control;

[0087] Soil pH value of the experimental site: 6.14

[0088] Experimental time: June 2021.

[0089] Method of application: The medicine and fertilizer were prepared into an aqueous solution and then applied by irrigation, drip irrigation or spraying, and the results are shown in Table 2.

[0090] Table 2

[0091] preparation Dosage of preparation Effective 20 days after transplanting 15g / L Kasugamycin fermentation solution 334mL 5.14％ Comparative Example 1 5kg / mu 20.25％ Comparative Example 2 5kg / mu 40.17％ Comparative Example 3 5kg / mu 80.17％ Comparative Example 4 5kg / mu 60.19％ Comparative Example 5 5kg / mu 65.27％ Comparative Example 6 5kg / mu 25.18％ 2% kasugamycin aqueous solution 25mL 70.34％ Example 1 5kg / mu 92.35％ Clear water control 5kg / mu ——

[0092] As can be seen from Table 2, the 15 g / L kasugamycin fermentation stock solution can be affected by various environments without protection measures, and a large amount of decomposition can directly lead to inactivation, and the control effect is only 5.14%. Although the comparative examples 1, 2, 4 and 5 have certain stability measures in some steps, the control effect is general, only 20.25%, 40.17%, 60.19% and 65.27%, which is not as good as the commercially available simple preparation product. Comparative example 6 shows that the combination of kasugamycin and hydrochloric acid is not very stable, and can still maintain relative stability in the water agent system, but as a raw material to make water-soluble fertilizer, the kasugamycin hydrochloride will be unstable and decomposed due to the contact with high salt such as nitrogen, phosphorus and potassium, and the control effect is very poor, only 25.18%. Comparative example 3 has good heat storage stability, but does not add potassium dihydrogen phosphate, and the control effect is 80.17%, which is still not ideal. The stable kasugamycin soluble powder medicine and fertilizer provided in example 1 of the present application ensures the stability of kasugamycin through solid kasugamycin phosphate, and on this basis, potassium dihydrogen phosphate is added to enhance the disease control effect, and the control effect is as high as 92.35%, which fully meets the demand of water medicine and fertilizer integration.

[0093] Those skilled in the art can understand that the above-mentioned embodiments are specific examples for implementing the present application, and in actual application, various changes can be made in form and details without departing from the spirit and scope of the present application.

Claims

1. A stable kasugamycin soluble powder fertilizer, characterized in that: The stable kasugamycin soluble powder fertilizer is composed of the following components in percentage by weight: 0.1-0.3% solid kasugamycin phosphate, 5-10% acid-base buffer, 10-15% monoammonium phosphate, 10-15% diammonium phosphate, 3-5% potassium dihydrogen phosphite, 20-25% potassium nitrate, 10-15% urea, 1-2% white carbon black, and fillers making up to 100%; Wherein, the solid kasugamycin phosphate is prepared according to the following method: First, the kasugamycin fermentation liquid is added to a reactor, followed by the addition of a phosphoric acid solution and a stabilizer, and the mixture is stirred at a constant temperature of 35-45°C for 25-35 minutes. Finally, a pH adjuster is added, and the mixture is stirred at a constant temperature of 8-12 minutes. After spray drying, solid kasugamycin phosphate is obtained. The stabilizer is one or a mixture of two or more of fatty acid soap, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, polyoxyethylene ether, polyoxypropylene ether, ethylene oxide and propylene oxide block copolymer, polyol fatty acid ester and polyvinyl alcohol; The pH regulator is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate; The mass ratio of the kasugamycin fermentation broth, the phosphoric acid solution, the stabilizer and the pH regulator is (20-50): (1-3): (1-3): (10-30).

2. The stable kasugamycin soluble powder fertilizer according to claim 1, wherein The concentration of the kasugamycin fermentation broth is 10-20 g / L; the concentration of the phosphoric acid solution is 80-90%; the pH adjuster is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of (1-3):1; the mass ratio of the kasugamycin fermentation broth, phosphoric acid solution, stabilizer and pH adjuster is (25-35):(1.5-2.5):(1.5-2.5):(15-25).

3. The stable kasugamycin soluble powder fertilizer according to claim 2, wherein The concentration of the kasugamycin fermentation broth is 15-18 g / L; the concentration of the phosphoric acid solution is 85%; the pH adjuster is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate in a mass ratio of 2:1; the mass ratio of the kasugamycin fermentation broth, phosphoric acid solution, stabilizer and pH adjuster is 30:2:2:

20.

4. The stable kasugamycin soluble powder fertilizer according to claim 1, wherein The acid-base buffer is a mixture of potassium dihydrogen phosphate and dipotassium hydrogen phosphate, with a mass ratio of (1-3):

1.

5. The stable kasugamycin soluble powder fertilizer according to claim 4, wherein The mass ratio of the potassium dihydrogen phosphate to dipotassium hydrogen phosphate is 2:

1.

6. The stable kasugamycin soluble powder fertilizer according to claim 1, wherein The filler is one or a mixture of two or more of sodium sulfate, magnesium sulfate and calcium lignin sulfonate.

7. The method for preparing the stable kasugamycin soluble powder fertilizer according to claim 1, characterized in that: The steps are as follows: (1) crushing and adsorbing solid kasugamycin phosphate and white carbon black together to obtain kasugamycin powder with a particle size of less than or equal to 30 μm; (2) Grinding the acid-base buffer, monoammonium phosphate, diammonium phosphate, potassium nitrate, potassium dihydrogen phosphite, urea and filler into powder respectively, and then mixing them evenly to obtain nutrient element powder; (3) The kasugamycin powder and the nutrient element powder were mixed in a fluidized bed air flow, and dried at a constant temperature of 60-80°C for 25-35 minutes to obtain a stable kasugamycin soluble powder fertilizer.

8. Use of the kasugamycin soluble powder fertilizer according to any one of claims 1 to 6 in increasing crop yield and preventing and controlling diseases, wherein the method of application is flushing, drip irrigation or spraying, and the single dosage per mu is 3 to 6 kg.

9. The use according to claim 8, characterized in that The crop is eggplant.

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