A traditional Chinese medicine external application patch for tonifying the kidney and fostering fetal development and its preparation method

Abstract

The present invention relates to a Chinese medicine external patch for strengthening kidney and nourishing fetus and a preparation method thereof, which is applied to Guanyuan acupoint of human body and comprises the following parts by weight and components thereof: 10-30 parts of wolfberry, 20-40 parts of dodder seed, 10-30 parts of raspberry, 1-20 parts of schisandra chinensis, 10-30 parts of plantain seed, 15-35 parts of calcined oyster, 1-20 parts of tangerine peel, 10-30 parts of dipsaccharum officinale, 10-30 parts of epimedium, 10-30 parts of polygonatum, 10-30 parts of raw rehmannia root, 10-30 parts of ophiopogon japonicus, 10-30 parts of atractylodes macrocephala, 10-30 parts of mountain ash 10-30 parts of Cornus officinalis, 10-30 parts of Rhizoma Curculigo, 10-30 parts of Radix Astragali, 10-30 parts of Rhizoma Chuanxiong, 10-30 parts of Radix Angelicae Sinensis, 10-30 parts of Notoginseng Leaves, 10-30 parts of Rhizoma Uncariae, 10-30 parts of Fructus Cuscutae, and 1-20 parts of Radix Glycyrrhizae can solve the problems of poor penetration, lack of obvious effect on patients with poor gastrointestinal function, and unstable effect existing in the prior art, effectively improve sperm deformity, and can improve the percentage of forward-moving sperm and sperm motility in the treatment of asthenozoospermia.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to an external application patch of traditional Chinese medicine for tonifying the kidney and nourishing the fetus and a preparation method thereof. Background Art

[0002] Asthenospermia refers to that after continuous and intermittent semen analysis by taking sperm three times, the percentage of sperm with forward motility (PR) in semen is lower than 32%, and other semen parameter reference values are within the normal range. Among the diseases causing male infertility, asthenospermia is common. Asthenospermia often coexists with oligozoospermia or teratozoospermia, and is collectively called oligoasthenozoospermia or asthenoteratozoospermia or oligoasthenoteratozoospermia (OAT). The infertility risk of asthenospermia patients is increased by 2-3 times compared with those with normal semen parameters, while that of oligoasthenozoospermia or asthenoteratozoospermia patients is increased by 5-7 times, and OAT is the highest, about 16 times.

[0003] Asthenospermia is the result of the action of complex multiple factors, and the causes include reproductive tract infection, varicocele, incomplete obstruction of the ejaculatory duct, immune factors, genetic factors, etc. Environmental factors, living habits, systemic diseases and other factors also have a certain impact on sperm motility. There are still 30%-40% of cases in which the cause and pathogenesis cannot be clarified, which is called idiopathic asthenozoospermia.

[0004] Teratozoospermia refers to that the percentage of sperm with normal morphology is lower than the lower limit of the reference value. According to the evaluation standard of sperm morphology in the "World Health Organization Laboratory Manual for the Examination and Processing of Human Semen (5th Edition)", the lower limit of the reference value of the percentage of sperm with normal morphology is 4%. Clinically, teratozoospermia is one of the common types of male infertility. However, due to certain difficulties in the evaluation of human sperm morphology and the lack of a completely unified evaluation standard, there is still a lack of epidemiological data on teratozoospermia in the male population in China. Sperm morphological defects can be divided into head defects, neck and midpiece defects, principal piece defects and excessive residual cytoplasm. Clinically, according to the types of the main abnormal sperm in sperm, it can be divided into globozoospermia, macrocephalospermia, acephalospermia, multiple morphological abnormalities of sperm flagella, amorphous head, etc.

[0005] The etiology of teratozoospermia is complex and closely related to multiple factors. Evidence has shown that varicocele (VC), male genital tract infection (MGTI), environmental factors, etc. can cause teratozoospermia. In addition, multiple pieces of evidence suggest that genetic factors can cause many special types of teratozoospermia. However, the etiology of some teratozoospermia patients is still unclear.

[0006] Wuzi Yanzong Pills is a famous kidney-tonifying prescription in my country with a history of thousands of years. It was first mentioned in the Wuzi Shouxian Recipe in the book "Taoism Xuanjielu" in the Tang Dynasty. The recipe of Wuzi Shouxian Recipe includes five Chinese medicines, such as Phyllanthus emblica, Rubus idaeus, Cuscuta chinensis, Schisandra chinensis, and Plantago asiatica. However, the existing Wuzi Yanzong Pills are generally used in pill form or decoction, that is, they are mainly taken orally. However, oral administration of this medicine requires gastrointestinal absorption, and there are problems such as poor penetration, no obvious effect on patients with poor gastrointestinal function, and unstable effect, which has become one of the main factors limiting the use of this prescription in the treatment of male asthenospermia and teratospermia. Summary of the invention

[0007] The purpose of the present invention is to provide a Chinese medicine external patch for strengthening the kidney and nourishing the fetus and a preparation method thereof, so as to solve the problems existing in the prior art such as poor penetrability, insignificant effect on patients with poor gastrointestinal function, and unstable effect.

[0008] In order to solve the above problems, the present invention provides a Chinese medicine external patch for strengthening the kidney and nourishing the fetus, which is applied to the Guanyuan acupoint of the human body, comprising the following parts by weight and their components: 10-30 parts of wolfberry, 20-40 parts of dodder seeds, 10-30 parts of raspberries, 1-20 parts of schisandra chinensis, 10-30 parts of plantain seeds, 15-35 parts of calcined oyster shells, 1-20 parts of tangerine peel, 10-30 parts of dipsacus root, 10-30 parts of epimedium, and 10-30 parts of tangerine peel. 10-30 parts, 10-30 parts of polygonatum, 10-30 parts of raw rehmannia, 10-30 parts of ophiopogon, 10-30 parts of atractylodes, 10-30 parts of cornus, 10-30 parts of parasitic, 10-30 parts of curculigo, 10-30 parts of astragalus, 10-30 parts of chuanxiong, 10-30 parts of angelica, 10-30 parts of notoginseng leaves, 10-30 parts of Uncaria rhynchophylla, 10-30 parts of paper mulberry seeds, and 1-20 parts of liquorice.

[0009] Strengthening the Kidney and Nurturing the Fetus Ecological Therapy (GSYT-ET) is a special therapy formed by the intersection of traditional Chinese medicine and ecology. It targets the relationship between human constitution and ecological environment. On the basis of using external application of strengthening the kidney and nurturing the fetus, it comprehensively considers the changes of the four seasons, selects Chinese medicine for the peaceful constitution to be taken and applied to the meridian acupoints, and combines it with modern medical examinations to regulate the human body's internal organs, meridians, qi and blood, as well as hormones, blood biochemistry, blood routine and other related indicators to achieve the "peaceful constitution" level of yin and yang balance, so that the human constitution can reach a balanced state of yin and yang, rebuild a balanced constitution, and thus achieve the ultimate goal of nourishing the fetus, conceiving, and having a child as desired.

[0010] The innovations of the eco-therapy of Gushen Yutai are as follows: ① Theoretical innovation of TCM treatment of infertility: The project uses the interdisciplinary study of TCM, ecology and pharmacology to form a complete theoretical system of eco-pharmaceutical therapy; ② Innovation in the practice of infertility treatment: Through the study of the eco-pharmacological mechanism of Gushen Yutai external application in reproductive medicine, the basic medicinal flavor matrix and eco-pharmaceutical therapy technical specifications of Gushen Yutai external application are established. ③ Multidisciplinary cross-fertilization, creative integration and development of TCM and ecological theories, provides new inspiration for the diagnosis and treatment of infertility.

[0011] Based on the ecological therapy of strengthening the kidney and nourishing the fetus, the Chinese medicine external patch for strengthening the kidney and nourishing the fetus was developed. It is a new therapeutic patch with extremely strong penetration and stability developed for male asthenozoospermia and teratozoospermia. It adopts the method of external application to greatly reduce toxic side effects and can be promoted and used in a wider population.

[0012] Wolfberry, Cuscuta, Rubus idaeus, Plantago and Schisandra chinensis are the main ingredients of Wu Zi Yan Zong Pills in Wonderful Prescriptions for Health Preservation. They are effective in nourishing the kidney and replenishing essence, and are a representative prescription for treating kidney deficiency and essence deficiency diseases such as impotence, infertility, spermatorrhea and premature ejaculation.

[0013] The liver and kidney have the same origin. Dipsacus asper, Epimedium, Herba Epimedii, Curculigo orchioides, Fructus Corni, and Semen Cuscutae can nourish the liver and kidney, strengthen the tendons and bones, and help the main medicine to nourish the kidney and replenish essence, and they are all assistant medicines.

[0014] Tangerine peel, Atractylodes macrocephala, Astragalus membranaceus, Polygonatum sibiricum, and Ophiopogon japonicus strengthen the spleen and replenish Qi, and treat spleen deficiency and other symptoms; Raw Rehmannia root, Chuanxiong, Angelica sinensis, and Panax notoginseng leaves promote blood circulation and remove blood stasis, and treat blood stasis and other symptoms; calcined oyster and Uncaria rhynchophylla astringe the essence and calm the mind, and treat spermatorrhea, excessive dreaming, damage to the essence, and symptoms of deficiency and restlessness; all of them are adjuvant drugs.

[0015] Licorice harmonizes various medicines and serves as a guiding medicine.

[0016] Based on Wu Zi Yan Zong Pills, a combination of 23 Chinese medicines, including auxiliary medicines, adjuvant medicines and guiding medicines, is used to form a Chinese medicine external patch for strengthening the kidney and nourishing the fetus. It enhances the penetration of drugs and is attached to the Guan Yuan acupoint of the human body to directly act on the lesion, effectively improving sperm deformity and treating asthenozoospermia. It can improve the percentage of forward-moving sperm in patients and enhance sperm motility.

[0017] Furthermore, it includes the following parts by weight and their components: 15 parts of wolfberry fruit, 25 parts of dodder seed, 12 parts of raspberry, 5 parts of schizandra fruit, 15 parts of plantain seed, 20 parts of calcined oyster, 6 parts of dried tangerine peel, 18 parts of teasel root, 15 parts of epimedium herb, 18 parts of polygonatum rhizome, 12 parts of rehmannia root, 12 parts of dwarf lilyturf tuber, 15 parts of atractylodes rhizome, 12 parts of dogwood fruit, 15 parts of taxillus twig, 15 parts of curculigo rhizome, 12 parts of astragalus root, 12 parts of chuanxiong rhizome, 15 parts of angelica root, 12 parts of gynura leaf, 15 parts of uncaria stem with hooks, 12 parts of broussonetia fruit, and 6 parts of licorice root.

[0018] Furthermore, it includes the following parts by weight and their components: 15 - 30 parts of wolfberry fruit, 25 - 40 parts of dodder seed, 12 - 30 parts of raspberry, 5 - 20 parts of schizandra fruit, 15 - 30 parts of plantain seed, 20 - 35 parts of calcined oyster, 6 - 20 parts of dried tangerine peel, 18 - 30 parts of teasel root, 15 - 30 parts of epimedium herb, 18 - 30 parts of polygonatum rhizome, 12 - 30 parts of rehmannia root, 12 - 30 parts of dwarf lilyturf tuber, 15 - 30 parts of atractylodes rhizome, 12 - 30 parts of dogwood fruit, 15 - 30 parts of taxillus twig, 15 - 30 parts of curculigo rhizome, 12 - 30 parts of astragalus root, 12 - 30 parts of chuanxiong rhizome, 15 - 30 parts of angelica root, 12 - 30 parts of gynura leaf, 15 - 30 parts of uncaria stem with hooks, 12 - 30 parts of broussonetia fruit, and 6 - 20 parts of licorice root.

[0019] Furthermore, it includes the following parts by weight and their components: 15 - 20 parts of wolfberry fruit, 25 - 30 parts of dodder seed, 12 - 20 parts of raspberry, 5 - 10 parts of schizandra fruit, 15 - 20 parts of plantain seed, 20 - 25 parts of calcined oyster, 6 - 10 parts of dried tangerine peel, 18 - 20 parts of teasel root, 15 - 20 parts of epimedium herb, 18 - 20 parts of polygonatum rhizome, 12 - 20 parts of rehmannia root, 12 - 20 parts of dwarf lilyturf tuber, 15 - 20 parts of atractylodes rhizome, 12 - 20 parts of dogwood fruit, 15 - 20 parts of taxillus twig, 15 - 20 parts of curculigo rhizome, 12 - 20 parts of astragalus root, 12 - 20 parts of chuanxiong rhizome, 15 - 20 parts of angelica root, 12 - 20 parts of gynura leaf, 15 - 20 parts of uncaria stem with hooks, 12 - 20 parts of broussonetia fruit, and 6 - 10 parts of licorice root.

[0020] Furthermore, it includes the following parts by weight and their components: 20 parts of wolfberry fruit, 30 parts of dodder seed, 20 parts of raspberry, 10 parts of schizandra fruit, 20 parts of plantain seed, 25 parts of calcined oyster, 10 parts of dried tangerine peel, 20 parts of teasel root, 20 parts of epimedium herb, 20 parts of polygonatum rhizome, 20 parts of rehmannia root, 20 parts of dwarf lilyturf tuber, 20 parts of atractylodes rhizome, 20 parts of dogwood fruit, 20 parts of taxillus twig, 20 parts of curculigo rhizome, 20 parts of astragalus root, 20 parts of chuanxiong rhizome, 20 parts of angelica root, 20 parts of gynura leaf, 20 parts of uncaria stem with hooks, 20 parts of broussonetia fruit, and 10 parts of licorice root.

[0021] Furthermore, it includes the following components in parts by weight: 10-15 parts of wolfberry fruits, 20-25 parts of dodder seeds, 10-12 parts of raspberry fruits, 1-5 parts of schizandra fruits, 10-15 parts of plantain seeds, 15-20 parts of calcined oyster, 1-6 parts of dried tangerine peel, 10-18 parts of teasel root, 10-15 parts of epimedium, 10-18 parts of polygonatum, 10-12 parts of rehmannia root, 10-12 parts of dwarf lilyturf tuber, 10-15 parts of largehead atractylodes rhizome, 10-12 parts of Asiatic cornel fruit, 10-15 parts of taxillus twig, 10-15 parts of curculigo rhizome, 10-12 parts of astragalus root, 10-12 parts of chuanxiong rhizome, 10-15 parts of Chinese angelica root, 10-12 parts of gynura divaricata leaf, 10-15 parts of uncaria stem with hooks, 10-12 parts of broussonetia fruit, and 1-6 parts of licorice root.

[0022] Furthermore, it includes the following components in parts by weight: 10 parts of wolfberry fruits, 20 parts of dodder seeds, 10 parts of raspberry fruits, 1 part of schizandra fruits, 10 parts of plantain seeds, 15 parts of calcined oyster, 1 part of dried tangerine peel, 10 parts of teasel root, 10 parts of epimedium, 10 parts of polygonatum, 10 parts of rehmannia root, 10 parts of dwarf lilyturf tuber, 10 parts of largehead atractylodes rhizome, 10 parts of Asiatic cornel fruit, 10 parts of taxillus twig, 10 parts of curculigo rhizome, 10 parts of astragalus root, 10 parts of chuanxiong rhizome, 10 parts of Chinese angelica root, 10 parts of gynura divaricata leaf, 10 parts of uncaria stem with hooks, 10 parts of broussonetia fruit, and 1 part of licorice root.

[0023] A preparation method of the above-mentioned traditional Chinese medicine external application patch for tonifying the kidney and fostering fetal growth includes the following steps:

[0024] A. Weigh each component according to the proportion, mix them evenly, and prepare a medicine bag.

[0025] B. Moisten the medicine bag with water and heat it until the water boils.

[0026] C. Keep boiling and continue steaming after the water boils.

[0027] D. Pour white liquor on the medicine bag after steaming ends.

[0028] E. Wait for the medicine bag to cool and the alcohol to volatilize to obtain the above-mentioned traditional Chinese medicine external application patch for tonifying the kidney and fostering fetal growth.

[0029] Furthermore, in step C, the steaming time is 20 minutes.

[0030] Furthermore, in step E, the medicine bag is cooled to 42 °C.

[0031] Compared with the prior art, through the synergistic effect of each component, the present invention forms a traditional Chinese medicine external application patch for tonifying the kidney and fostering fetal growth, enhances the penetration power, acts on the Guanyuan acupoint of the human body together, and has the effects of tonifying the kidney and replenishing essence, strengthening the spleen and benefiting the liver, promoting qi and dispersing stasis, and astringing sperm and calming the mind. It can treat patients with asthenospermia infertility and sexual dysfunction infertility caused by deficiency of liver and kidney essence and spleen deficiency with dreaminess, such as soreness and weakness of the waist and knees, fatigue, spermatorrhea, etc. Treating asthenospermia can improve the percentage of sperm with forward motility in patients and enhance sperm motility. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] Figure 1 This is a schematic diagram of the semen of a patient before treatment in Example 1;

[0033] Figure 2 This is a schematic diagram of the semen routine of a patient after treatment in Example 1;

[0034] Figure 3 This is a schematic diagram of the semen routine of a patient before treatment in Example 2;

[0035] Figure 4 This is a schematic diagram of the semen routine of a patient after treatment in Example 2;

[0036] Figure 5 This is a schematic diagram of the semen routine of a patient before treatment in Example 3;

[0037] Figure 6 This is a schematic diagram of the semen routine of a patient after treatment in Example 3;

[0038] Figure 7 This is a schematic diagram of the sperm morphology of a patient before treatment in Example 4;

[0039] Figure 8 This is a schematic diagram of the sperm morphology of the patient after treatment in Example 4. DETAILED DESCRIPTION

[0040] In order to make the purpose, technical solutions and advantages of the present invention more clear, the present invention will be described in further detail below.

[0041] Example 1

[0042] A Chinese medicine external patch for strengthening the kidney and nourishing the fetus is applied to the Guanyuan acupoint of the human body, comprising the following parts by weight and their components: 15 parts of wolfberry fruit, 25 parts of dodder seed, 12 parts of raspberry, 5 parts of schisandra chinensis, 15 parts of plantain seed, 20 parts of calcined oyster shell, 6 parts of dried tangerine peel, 18 parts of dipsaccharum officinale, 15 parts of epimedium, 18 parts of polygonatum, 12 parts of raw rehmannia root, 12 parts of ophiopogon japonicus, 15 parts of atractylodes macrocephala, 12 parts of cornus fruit, 15 parts of parasitic plant, 15 parts of curculigo orchioides, 12 parts of astragalus, 12 parts of ligusticum chuanxiong, 15 parts of angelica, 12 parts of notoginseng leaf, 15 parts of Uncaria rhynchophylla, 12 parts of paper mulberry fruit, and 6 parts of liquorice.

[0043] Hong xx, 31 years old, had a routine semen test on March 17, 2022. Figure 1 As shown: 26.1% of sperms were motile and 41.2% of sperms were motile. The patient was diagnosed with asthenospermia.

[0044] The above-mentioned Chinese medicine external application patch for strengthening kidney and nourishing fetus was applied to Guanyuan acupoint for more than 3 hours each time, 5 times a week (week 1-5). The usage is:

[0045] 1. Soak the medicine bag with water first.

[0046] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0047] 3. Pour an appropriate amount of white liquor over the steamed medicine.

[0048] 4. When the medicine bag cools down to a suitable temperature (42°), apply it externally to the Guanyuan acupoint.

[0049] 5. Cover a hot towel over the medicine bag to make the medicine smell penetrate directly to the meridians and internal organs and prevent the efficacy of the medicine from volatilizing.

[0050] 6. Each bag can be used 3 - 5 times.

[0051] After three months of treatment, a semen routine examination was conducted on July 7, 2022, as Figure 2 shown: The percentage of sperm with forward motility was 36.4%, and the total motility was 53.8%. The treatment effect was remarkable.

[0052] Example 2

[0053] A traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus, applied to the Guanyuan acupoint of the human body, comprising the following components in parts by weight: 30 parts of wolfberry fruit, 40 parts of dodder seed, 30 parts of raspberry, 20 parts of schisandra fruit, 30 parts of plantain seed, 35 parts of calcined oyster, 20 parts of dried tangerine peel, 30 parts of rehmannia root, 30 parts of epimedium, 30 parts of polygonatum, 30 parts of raw rehmannia root, 30 parts of dwarf lilyturf tuber, 30 parts of atractylodes macrocephala, 30 parts of dogwood fruit, 30 parts of taxillus twig, 30 parts of curculigo rhizome, 30 parts of astragalus root, 30 parts of chuanxiong rhizome, 30 parts of angelica root, 30 parts of gynura divaricata leaf, 30 parts of uncaria rhynchophylla, 30 parts of broussonetia fruit, and 20 parts of licorice root.

[0054] Lin xx, 34 years old, had a semen routine examination on October 27, 2021, as Figure 3 shown: The percentage of sperm with forward motility was 22.1%, and was diagnosed with asthenospermia.

[0055] The above-mentioned traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus was given for external application treatment, applied to the Guanyuan acupoint for more than 3 hours each time, 5 times a week (Monday - Friday). The usage method is as follows:

[0056] 1. First, soak the medicine bag with water.

[0057] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0058] 3. Pour an appropriate amount of white liquor over the steamed medicine.

[0059] 4. When the medicine bag cools down to a suitable temperature (42°), apply it externally to the Guanyuan acupoint.

[0060] 5. Cover a hot towel over the medicine bag to make the medicine smell penetrate directly to the meridians and internal organs and prevent the efficacy of the medicine from volatilizing.

[0061] 6. Each bag can be used 3 - 5 times.

[0062] After three months of treatment, the semen routine was rechecked on January 26, 2022. Figure 4 Shown: 35% of sperm are moving forward, and the treatment effect is significant.

[0063] Example 3

[0064] A Chinese medicine external patch for strengthening the kidney and nourishing the fetus is applied to the Guanyuan acupoint of the human body, comprising the following parts by weight and their components: 20 parts of wolfberry fruit, 30 parts of dodder seed, 20 parts of raspberry, 10 parts of schisandra chinensis, 20 parts of plantain seed, 25 parts of calcined oyster shell, 10 parts of dried tangerine peel, 20 parts of dipsaccharum officinale, 20 parts of epimedium, 20 parts of polygonatum, 20 parts of raw rehmannia root, 20 parts of ophiopogon japonicus, 20 parts of atractylodes macrocephala, 20 parts of cornus fruit, 20 parts of parasitic wormwood, 20 parts of curculigo orchioides, 20 parts of astragalus, 20 parts of ligusticum chuanxiong, 20 parts of angelica, 20 parts of notoginseng leaf, 20 parts of Uncaria rhynchophylla, 20 parts of paper mulberry fruit, and 10 parts of liquorice.

[0065] Zeng xx, 29 years old, had a routine semen test on March 10, 2022. Figure 5 As shown: 29.1% of sperm motile, semen concentration 28.6 million / ml. Diagnosed as asthenospermia.

[0066] The above-mentioned Chinese medicine external application patch for strengthening kidney and nourishing fetus was applied to Guanyuan acupoint for more than 3 hours each time, 5 times a week (week 1-5). The usage is:

[0067] 1. Soak the medicine bag with water first.

[0068] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0069] 3. After steaming, pour appropriate amount of white wine.

[0070] 4. When the medicine bag cools to the appropriate temperature (42°), apply it to Guanyuan acupoint.

[0071] 5. Cover the medicine bag with a hot towel to allow the medicinal flavor to penetrate directly into the meridians and internal organs and prevent the medicinal effects from evaporating.

[0072] 6. Use each pack 3-5 times.

[0073] After three months of treatment, the semen routine examination was conducted on July 13, 2022. Figure 6 As shown: 38.1% of sperm are moving forward, the semen concentration is 62.3 million / ml, and the treatment effect is significant.

[0074] Example 4

[0075] A Chinese medicine external patch for strengthening the kidney and nourishing the fetus is applied to the Guanyuan acupoint of the human body, comprising the following parts by weight and their components: 10 parts of wolfberry fruit, 20 parts of dodder seed, 10 parts of rubus idaeus, 1 part of schisandra chinensis, 10 parts of plantain seed, 15 parts of calcined oyster shell, 1 part of dried tangerine peel, 10 parts of dipsaccharum officinale, 10 parts of epimedium, 10 parts of polygonatum, 10 parts of raw rehmannia root, 10 parts of ophiopogon japonicus, 10 parts of atractylodes macrocephala, 10 parts of cornus fruit, 10 parts of parasitic wormwood, 10 parts of curculigo orchioides, 10 parts of astragalus, 10 parts of ligusticum chuanxiong, 10 parts of angelica sinensis, 10 parts of notoginseng leaves, 10 parts of uncaria, 10 parts of chumarginata fruit, and 1 part of liquorice.

[0076] Huang x, 27 years old, had his sperm morphology checked on December 26, 2020. Figure 7 Shown: Normal sperm 1%, diagnosed as teratospermia.

[0077] The above-mentioned Chinese medicine external application patch for strengthening kidney and nourishing fetus was applied to Guanyuan acupoint for more than 3 hours each time, 5 times a week (week 1-5). The usage is:

[0078] 1. Soak the medicine bag with water first.

[0079] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0080] 3. After steaming, pour appropriate amount of white wine.

[0081] 4. When the medicine bag cools to the appropriate temperature (42°), apply it to Guanyuan acupoint.

[0082] 5. Cover the medicine bag with a hot towel to allow the medicinal flavor to penetrate directly into the meridians and internal organs and prevent the medicinal effects from evaporating.

[0083] 6. Use each pack 3-5 times.

[0084] After more than three months of treatment, there was a significant improvement. On May 10, 2021, the sperm morphology was rechecked. Figure 8 Shown: Normal sperm 3.6%, the treatment effect is significant.

[0085] Effect Example 1

[0086] Experimental study on the efficacy of Gushen Yutai Chinese medicine external application patch in treating teratozoospermia

[0087] 1. Materials and methods

[0088] 1.1 Clinical Data

[0089] The research subjects were 108 patients with teratospermia who visited the Traditional Chinese Medicine (TCM) Gynecology Clinic of Shantou Central Hospital from July 2018 to June 2019. They were divided into a treatment group, control group A, and control group B using the random number table method, with 36 cases in each group. Among them, there were 36 cases in the treatment group, with the oldest age being 43 years old and the youngest being 25 years old, with an average age of 30.26 ± 3.12 years; the shortest disease course was 1 year and the longest was 4.5 years, with an average disease course of 2.30 ± 0.81 years. There were 36 cases in control group A, with the oldest age being 44 years old and the youngest being 22 years old, with an average age of 30.14 ± 3.48 years; the shortest disease course was 1 year and the longest was 5 years, with an average disease course of 2.41 ± 0.92 years. There were 36 cases in control group B, with the oldest age being 45 years old and the youngest being 24 years old, with an average age of 30.51 ± 3.16 years; the shortest disease course was 1 year and the longest was 4.5 years, with an average disease course of 2.34 ± 0.83 years. After normal distribution test and independent sample t-test, there were no significant differences in age and disease course between the two groups of cases, and they were comparable (P > 0.05). See Table 1:

[0090] Table 1 Comparison of general conditions of two groups of patients

[0091]

[0092] Note: Comparison of age and disease course between two groups of patients, * P > 0.05.

[0093] 1.2 Diagnostic criteria

[0094] The Western medicine diagnostic criteria were formulated with reference to the fifth edition of "WHO Laboratory Manual for the Examination and Processing of Human Semen" as follows: 1) Husband and wife cohabited for 1 year, had normal sexual life, did not use contraception and were not pregnant; 2) Sperm morphology detection: The ratio of normal sperm was < 4%; Those who met both items 1) and 2) were diagnosed with teratospermia.

[0095] The TCM dialectical criteria for infertility due to kidney essence deficiency were formulated with reference to "Diagnostics of Traditional Chinese Medicine" and "Andrology of Traditional Chinese Medicine": Main symptoms: Failure to conceive for more than one year, soreness and weakness of the waist and knees; Secondary symptoms: Decreased libido, impotence, premature ejaculation, spermatorrhea, frequent nocturia, tinnitus, listlessness. The diagnosis was established when one main symptom and any two secondary symptoms were present.

[0096] 1.3 Inclusion criteria

[0097] 1) Aged 24 - 45 years; 2) Those who met the diagnostic criteria for teratospermia; 3) Those who met the TCM dialectical criteria for infertility due to kidney essence deficiency;

[0098] 1.4 Exclusion criteria

[0099] 1) Those under 24 years old or over 45 years old; 2) Those with chromosomal abnormalities; 3) Those with organic lesions such as cryptorchidism or severe varicocele; 4) Those with congenital reproductive system dysplasia; 5) Those with reproductive and urinary tract infections; 6) Those with serious underlying diseases; 7) Those who have received other drugs or therapies that may affect infertility within 2 months before treatment and during treatment; 8) Those with liver and kidney dysfunction.

[0100] 1.5 Treatment

[0101] Control group A was given commercially available Wuzi Yanzong Pills (approval number: National Medicine Standard Z13020463, specification: 6g*8 bags), orally, 6g each time, twice a day;

[0102] Control group B was given 15 parts of wolfberry, 25 parts of dodder seeds, 12 parts of raspberries, 5 parts of schisandra chinensis, and 15 parts of plantain seeds. After soaking in water for 30 minutes, they were first decocted with high heat until boiling, then decocted with low heat for 30 minutes, filtered to obtain the first filtrate; the residues were immersed in water again, boiled with high heat, then decocted with low heat for 25-30 minutes, filtered to obtain the second filtrate; the two filtrates were combined and concentrated to 400-500mL, taken twice a day, 200-250ml each time, and taken warm 2 hours after meals in the morning and evening;

[0103] The treatment group was given the Chinese medicine external application patch for strengthening the kidney and nourishing the fetus as shown in Example 1, applied to Guanyuan acupoint for more than 3 hours each time, 5 times a week (week 1-5). The method of use is:

[0104] 1. Soak the medicine bag with water first.

[0105] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0106] 3. After steaming, pour appropriate amount of white wine.

[0107] 4. When the medicine bag cools to the appropriate temperature (42°), apply it to Guanyuan acupoint.

[0108] 5. Cover the medicine bag with a hot towel to allow the medicinal flavor to penetrate directly into the meridians and internal organs and prevent the medicinal effects from evaporating.

[0109] 6. Use each pack 3-5 times.

[0110] Both groups were treated for 12 weeks.

[0111] 1.6 Observation indicators

[0112] 1.6.1 Safety indicators

[0113] Routine blood, urine, stool tests, liver and kidney function tests, electrocardiogram.

[0114] 1.6.2 Observation indicators

[0115] After treatment, the normal sperm morphology rate, sperm motility rate, pregnancy rate of the spouses, etc. of the two groups of patients were observed.

[0116] 1.7 Efficacy judgment criteria

[0117] Refer to the relevant standards in the "WHO Laboratory Manual for the Examination and Processing of Human Semen" and the "Guiding Principles for Clinical Research of New Chinese Medicines". Cure: The spouse confirms pregnancy; Marked effect: The normal sperm morphology rate is greater than 4%, and the spouse is not pregnant; Effective: The normal sperm morphology rate after treatment is improved compared with before, but less than 4%; Ineffective: The normal sperm morphology rate shows no improvement before and after treatment, and is even lower than before treatment.

[0118] 1.8 Statistical analysis

[0119] SPSS 22.0 statistical software was used. Measurement data were expressed as mean ± standard deviation (x±s). First, normality and homogeneity of variance tests were performed. For those conforming to normal distribution, independent sample t-tests were used for between-group analysis and paired sample t-tests were used for within-group analysis. Among them, for those with inhomogeneous variance, corrected t-tests were used; for those not conforming to normal distribution, corrected t-tests were used; chi-square 2 tests were used for comparison of count data; rank sum tests were used for comparison of rank data. P < 0.05 was considered statistically significant.

[0120] 2. Results

[0121] 2.1 Comparison of the efficacy of the two groups of patients

[0122] The total effective rate of the treatment group was 86.11%; the total effective rate of control group A was 61.11%, and the total effective rate of control group B was 80.56%. There was a statistically significant difference in the effective rate between the treatment group and the control groups (p < 0.05). See Table 2:

[0123] Table 2 Comparison of the general conditions of the three groups of patients Cases (%)

[0124]

[0125] 2.2 Comparison of the normal sperm morphology rate of the two groups of patients

[0126] Compared with before treatment, the normal sperm morphology rate of the three groups of patients increased significantly (p < 0.05). The normal sperm morphology rate of the treatment group was higher than that of the control groups (p < 0.05). See Table 3:

[0127] Table 3 Comparison of the normal sperm morphology rate of the three groups of patients before and after treatment

[0128] Group Number of cases Before treatment After treatment Control group A 36 2.51±0.52 <![CDATA[4.23±0.82 △ > Control group B 36 2.42±0.68 <![CDATA[4.27±0.35 △ > Treatment group 36 2.47±0.63 <![CDATA[4.69±0.91 △▲ >

[0129] Note: Compared with before treatment in this group, △p < 0.05, compared with after treatment in the control group, ▲p < 0.05.

[0130] 2.3 Comparison of total sperm motility in two groups of patients

[0131] Compared with before treatment, the total sperm motility of the three groups of patients increased significantly (p < 0.05). The total sperm motility of the treatment group was higher than that of the control group (p < 0.05). See Table 4:

[0132] Table 4 Comparison of total sperm motility in three groups of patients before and after treatment

[0133]

[0134]

[0135] Note: Compared with before treatment in this group, △p < 0.05; compared with the control group after treatment, ▲p < 0.05.

[0136] 2.4 Evaluation of safety indicators

[0137] For all patients participating in the trial, the results of indicators such as blood, urine, fecal routine, electrocardiogram, liver and kidney function before and after treatment were normal, and no drug adverse reactions occurred during the treatment, indicating that this drug has good safety.

[0138] 3. Conclusion

[0139] The external application of the traditional Chinese medicine sticking plaster for strengthening the kidney and nourishing the fetus in this application has stronger penetration and more stable effects compared with pills and decoctions. Treating teratospermia can improve the sperm deformity rate of patients and increase sperm motility.

[0140] Effect Example 2

[0141] Efficacy experiment of the traditional Chinese medicine sticking plaster for strengthening the kidney and nourishing the fetus in the treatment of asthenospermia infertility

[0142] 1. Data and methods

[0143] 1.1 Clinical data

[0144] The research subjects were patients with asthenospermia who visited the Traditional Chinese Medicine (TCM) Gynecology Clinic of Shantou Central Hospital from January 2019 to December 2020. None of them had other diseases, and their spouses had normal reproductive functions. There were a total of 180 cases. They were divided into a treatment group, control group A, and control group B using the random number table method, with 60 cases in each group. Among them, there were 60 cases in the treatment group, with an average age of 31.15 ± 4.85 years and an average disease course of 3.16 ± 1.38 years. There were 50 cases in control group A, with an average age of 31.40 ± 4.52 years and an average disease course of 3.01 ± 1.03 years. There were 36 cases in control group B, with an average age of 30.87 ± 4.12 years and an average disease course of 3.22 ± 1.27 years. After normal distribution test and independent sample t-test, there were no significant differences in age and disease course between the two groups of cases, and they were comparable (P > 0.05).

[0145] 1.2 Diagnostic criteria

[0146] 1.2.1 Western medicine diagnostic criteria

[0147] Diagnostic criteria for male infertility (EAU Guidelines on Male Infertility, 2017 edition): For couples of childbearing age who have cohabited for more than one year, have normal sexual life, and are unable to conceive due to male factors without contraception.

[0148] The diagnostic criteria for asthenospermia were formulated with reference to the fifth edition of the "WHO Laboratory Manual for the Examination and Processing of Human Semen" as follows: The sperm motility rate (PR%) of sperm with forward movement within 1 hour ≤ 32%, and the total sperm motility (PR% + NP%) ≤ 40%.

[0149] The criteria for TCM kidney yin deficiency syndrome were formulated with reference to the "Diagnostic and Therapeutic Criteria for TCM Diseases and Syndromes" and the "Guiding Principles for Clinical Research of New TCM Drugs": Main symptoms: Failure to conceive for more than one year, low sperm concentration and low motility rate; Secondary symptoms: Soreness and weakness in the waist and knees, red tongue with little coating, feverish sensation in the five centers (palms, soles, and chest), premature ejaculation, spermatorrhea, frequent nocturia, listlessness, fatigue, and thready and weak pulse. One main symptom and any two secondary symptoms are required.

[0150] 1.3 Inclusion criteria

[0151] 1) Aged 24 - 45 years; 2) Those who meet the above Western medicine diagnostic criteria; 3) Those who meet the dialectical criteria of "kidney yin deficiency syndrome" in TCM.

[0152] 1.4 Exclusion criteria

[0153] 1) Those under 24 years old or over 45 years old; 2) Those who do not meet the inclusion criteria; 3) Those with major diseases; 4) Those with organic lesions in the reproductive system; 5) Those with abnormal endocrine examinations; 6) Those who have received other drugs or therapies that affect this disease.

[0154] 1.5 Treatment methods

[0155] Control group A was given commercially available Wuzi Yanzong Pills (approval number: National Medicine Standard Z13020463, specification: 6g*8 bags), orally, 6g each time, twice a day;

[0156] Control group B was given 15 parts of wolfberry, 25 parts of dodder seeds, 12 parts of raspberries, 5 parts of schisandra chinensis, and 15 parts of plantain seeds. After soaking in water for 30 minutes, they were first decocted with high heat until boiling, then decocted with low heat for 30 minutes, filtered to obtain the first filtrate; the residues were immersed in water again, boiled with high heat, then decocted with low heat for 25-30 minutes, filtered to obtain the second filtrate; the two filtrates were combined and concentrated to 400-500mL, taken twice a day, 200-250ml each time, and taken warm 2 hours after meals in the morning and evening;

[0157] The treatment group was given the Chinese medicine external application patch for strengthening the kidney and nourishing the fetus as shown in Example 1, applied to Guanyuan acupoint for more than 3 hours each time, 5 times a week (week 1-5). The method of use is:

[0158] 1. Soak the medicine bag with water first.

[0159] 2. After the water boils, turn to low heat and steam for 20 minutes.

[0160] 3. After steaming, pour appropriate amount of white wine.

[0161] 4. When the medicine bag cools to the appropriate temperature (42°), apply it to Guanyuan acupoint.

[0162] 5. Cover the medicine bag with a hot towel to allow the medicinal flavor to penetrate directly into the meridians and internal organs and prevent the medicinal effects from evaporating.

[0163] 6. Use each pack 3-5 times.

[0164] Both groups were treated for 12 weeks.

[0165] 1.6 Observation indicators

[0166] 1.6.1 Safety indicators

[0167] Routine blood, urine, stool tests, liver and kidney function tests, electrocardiogram.

[0168] 1.6.2 Observation indicators

[0169] The percentage of sperm forward movement (PR) and sperm survival rate were observed before and after treatment.

[0170] 1.7 Criteria for determining efficacy

[0171] The method was formulated with reference to the relevant standards in the WHO Laboratory Manual for the Examination and Processing of Human Semen. Cured: semen parameters return to normal and the couple conceives; markedly effective: all parameters of routine semen examinations reach normal standards; effective: sperm motility and survival rate are improved, and clinical symptoms are improved; ineffective: semen parameters remain unchanged. Total effective rate = cure rate + markedly effective rate + effective rate.

[0172] 1.8 Statistical analysis

[0173] SPSS 22.0 statistical software was used. Measurement data were expressed as mean ± standard deviation (x±s). First, normality and homogeneity of variance tests were performed. For those conforming to normal distribution, independent sample t-test was used for between-group analysis and paired sample t-test was used for within-group analysis. Among them, for those with inhomogeneous variance, corrected t-test was used; for those not conforming to normal distribution, corrected t-test was used; χ2 test was used for comparison of count data; rank sum test was used for comparison of ranked data. P < 0.05 was considered statistically significant difference.

[0174] 2. Results

[0175] 2.1 Basic conditions of two groups of patients

[0176] During the trial period, 10 patients were dropped out or deleted. Among them, 2 patients in the treatment group did not complete the full course of treatment and 1 was lost to follow-up later; 3 patients in control group A did not complete the full course of treatment, and 1 patient used drugs that had an impact on this disease during the trial period, so it was excluded. 2 patients in control group B did not complete the full course of treatment, and 1 patient used drugs that had an impact on this disease during the trial period, so it was excluded. Finally, 170 effective cases were available for analysis, with 57 cases in the treatment group, 56 cases in control group A, and 57 cases in control group B.

[0177] 2.2 Comparison of curative effects of two groups of patients

[0178] The total effective rate of the treatment group was 84.21%; the total effective rate of control group A was 66.07%, and the total effective rate of control group B was 82.46%. When comparing the effective rates between the treatment group and the control groups, the difference was statistically significant (p < 0.05). See Table 5:

[0179] Table 5 Comparison of clinical curative effects of three groups of patients (%)

[0180] Group Number of cases Cured Markedly effective Effective Ineffective Effective rate (%) Control group A 56 5 9 23 19 66.07 Control group B 57 10 19 18 10 82.46 Treatment group 57 12 16 20 9 84.21

[0181] 2.2 Percentage of sperm progressive motility and sperm survival rate of two groups of patients

[0182] Compared with before treatment, after treatment, the PR and sperm survival rates of the three groups of patients were improved, and the difference was statistically significant (p < 0.05). When comparing the three groups after treatment, the improvement of PR and sperm survival rate in the treatment group was more significant than that in the control groups, and the difference was statistically significant (p < 0.05). See Table 6:

[0183] Table 6 Comparison of PR and sperm survival rate of three groups of patients

[0184]

[0185] Note: Compared with before the treatment in this group, △p < 0.05; compared with after the treatment in the control group, ▲p < 0.05.

[0186] 2.3 Evaluation of safety indicators

[0187] For all patients participating in the trial, no abnormalities were found in the results of routine blood, urine, feces, electrocardiogram, liver and kidney function and other indicators before and after treatment, and no drug adverse reactions occurred during the treatment, indicating that this drug has good safety.

[0188] 3. Conclusion

[0189] The external application of the traditional Chinese medicine for tonifying the kidney and nurturing the fetus in this application has stronger penetration and more stable effects compared with pills and decoctions. Treating asthenospermia can improve the percentage of sperm with forward motility in patients and enhance sperm motility.

[0190] The above-disclosed are only the preferred embodiments of the present invention. Of course, the scope of the rights of the present invention cannot be limited thereby. Therefore, equivalent changes made according to the claims of the present invention still fall within the scope covered by the present invention.

Claims

1. A traditional Chinese medicine external application patch for tonifying the kidney and nurturing the fetus, which is characterized in that it is applied to the Guanyuan acupoint of the human body and is made from the following raw materials in parts by weight: 10 - 30 parts of wolfberry fruit, 20 - 40 parts of dodder seeds, 10 - 30 parts of raspberry, 1 - 20 parts of schizandra fruit, 10 - 30 parts of plantain seed, 15 - 35 parts of calcined oyster, 1 - 20 parts of dried tangerine peel, 10 - 30 parts of teasel root, 10 - 30 parts of epimedium, 10 - 30 parts of polygonatum, 10 - 30 parts of rehmannia root, 10 - 30 parts of dwarf lilyturf tuber, 10 - 30 parts of largehead atractylodes rhizome, 10 - 30 parts of dogwood fruit, 10 - 30 parts of taxillus twig, 10 - 30 parts of curculigo rhizome, 10 - 30 parts of astragalus root, 10 - 30 parts of chuanxiong rhizome, 10 - 30 parts of angelica root, 10 - 30 parts of gynura leaf, 10 - 30 parts of uncaria, 10 - 30 parts of broussonetia fruit, 1 - 20 parts of liquorice root.

2. The traditional Chinese medicine external application patch for tonifying the kidney and nurturing the fetus according to claim 1, which is characterized in that it is made from the following raw materials in parts by weight: 15 parts of wolfberry fruit, 25 parts of dodder seeds, 12 parts of raspberry, 5 parts of schizandra fruit, 15 parts of plantain seed, 20 parts of calcined oyster, 6 parts of dried tangerine peel, 18 parts of teasel root, 15 parts of epimedium, 18 parts of polygonatum, 12 parts of rehmannia root, 12 parts of dwarf lilyturf tuber, 15 parts of largehead atractylodes rhizome, 12 parts of dogwood fruit, 15 parts of taxillus twig, 15 parts of curculigo rhizome, 12 parts of astragalus root, 12 parts of chuanxiong rhizome, 15 parts of angelica root, 12 parts of gynura leaf, 15 parts of uncaria, 12 parts of broussonetia fruit, 6 parts of liquorice root.

3. The traditional Chinese medicine external application patch for tonifying the kidney and nurturing the fetus according to claim 1, which is characterized in that it is made from the following raw materials in parts by weight: 15 - 30 parts of wolfberry fruit, 25 - 40 parts of dodder seeds, 12 - 30 parts of raspberry, 5 - 20 parts of schizandra fruit, 15 - 30 parts of plantain seed, 20 - 35 parts of calcined oyster, 6 - 20 parts of dried tangerine peel, 18 - 30 parts of teasel root, 15 - 30 parts of epimedium, 18 - 30 parts of polygonatum, 12 - 30 parts of rehmannia root, 12 - 30 parts of dwarf lilyturf tuber, 15 - 30 parts of largehead atractylodes rhizome, 12 - 30 parts of dogwood fruit, 15 - 30 parts of taxillus twig, 15 - 30 parts of curculigo rhizome, 12 - 30 parts of astragalus root, 12 - 30 parts of chuanxiong rhizome, 15 - 30 parts of angelica root, 12 - 30 parts of gynura leaf, 15 - 30 parts of uncaria, 12 - 30 parts of broussonetia fruit, 6 - 20 parts of liquorice root.

4. The traditional Chinese medicine external application patch for tonifying the kidney and nurturing the fetus according to claim 1, which is characterized in that it is made from the following raw materials in parts by weight: 15 - 20 parts of wolfberry fruit, 25 - 30 parts of dodder seeds, 12 - 20 parts of raspberry, 5 - 10 parts of schizandra fruit, 15 - 20 parts of plantain seed, 20 - 25 parts of calcined oyster, 6 - 10 parts of dried tangerine peel, 18 - 20 parts of teasel root, 15 - 20 parts of epimedium, 18 - 20 parts of polygonatum, 12 - 20 parts of rehmannia root, 12 - 20 parts of dwarf lilyturf tuber, 15 - 20 parts of largehead atractylodes rhizome, 12 - 20 parts of dogwood fruit, 15 - 20 parts of taxillus twig, 15 - 20 parts of curculigo rhizome, 12 - 20 parts of astragalus root, 12 - 20 parts of chuanxiong rhizome, 15 - 20 parts of angelica root, 12 - 20 parts of gynura leaf, 15 - 20 parts of uncaria, 12 - 20 parts of broussonetia fruit, 6 - 10 parts of liquorice root.

5. The traditional Chinese medicine external application patch for tonifying the kidney and nurturing the fetus according to claim 1, which is characterized in that It is made from the following raw materials in parts by weight: 20 parts of wolfberry fruits, 30 parts of dodder seeds, 20 parts of raspberry fruits, 10 parts of schisandra fruits, 20 parts of plantain seeds, 25 parts of calcined oyster, 10 parts of dried tangerine peel, 20 parts of rehmannia root, 20 parts of epimedium herb, 20 parts of polygonatum rhizome, 20 parts of raw rehmannia root, 20 parts of dwarf lilyturf tuber, 20 parts of largehead atractylodes rhizome, 20 parts of Asiatic cornel fruit, 20 parts of taxillus twig, 20 parts of curculigo rhizome, 20 parts of astragalus root, 20 parts of chuanxiong rhizome, 20 parts of Chinese angelica root, 20 parts of gynura leaf, 20 parts of uncaria stem with hooks, 20 parts of broussonetia fruit, and 10 parts of liquorice root.

6. The traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus according to claim 1, characterized in that it is made from the following raw materials in parts by weight: 10 - 15 parts of wolfberry fruits, 20 - 25 parts of dodder seeds, 10 - 12 parts of raspberry fruits, 1 - 5 parts of schisandra fruits, 10 - 15 parts of plantain seeds, 15 - 20 parts of calcined oyster, 1 - 6 parts of dried tangerine peel, 10 - 18 parts of rehmannia root, 10 - 15 parts of epimedium herb, 10 - 18 parts of polygonatum rhizome, 10 - 12 parts of raw rehmannia root, 10 - 12 parts of dwarf lilyturf tuber, 10 - 15 parts of largehead atractylodes rhizome, 10 - 12 parts of Asiatic cornel fruit, 10 - 15 parts of taxillus twig, 10 - 15 parts of curculigo rhizome, 10 - 12 parts of astragalus root, 10 - 12 parts of chuanxiong rhizome, 10 - 15 parts of Chinese angelica root, 10 - 12 parts of gynura leaf, 10 - 15 parts of uncaria stem with hooks, 10 - 12 parts of broussonetia fruit, and 1 - 6 parts of liquorice root.

7. The traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus according to claim 1, characterized in that it is made from the following raw materials in parts by weight: 10 parts of wolfberry fruits, 20 parts of dodder seeds, 10 parts of raspberry fruits, 1 part of schisandra fruits, 10 parts of plantain seeds, 15 parts of calcined oyster, 1 part of dried tangerine peel, 10 parts of rehmannia root, 10 parts of epimedium herb, 10 parts of polygonatum rhizome, 10 parts of raw rehmannia root, 10 parts of dwarf lilyturf tuber, 10 parts of largehead atractylodes rhizome, 10 parts of Asiatic cornel fruit, 10 parts of taxillus twig, 10 parts of curculigo rhizome, 10 parts of astragalus root, 10 parts of chuanxiong rhizome, 10 parts of Chinese angelica root, 10 parts of gynura leaf, 10 parts of uncaria stem with hooks, 10 parts of broussonetia fruit, and 1 part of liquorice root.

8. A preparation method of the traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus according to any one of claims 1 - 7, characterized in that it includes the following steps: A. Weigh each component according to the proportion, mix them evenly, and prepare a medicine bag; B. Moisten the medicine bag with water and heat it until the water boils; C. Keep boiling and continue to steam after the water boils; D. Pour white liquor on the medicine bag after steaming; E. Wait for the medicine bag to cool and the alcohol to volatilize to obtain the traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus.

9. The preparation method of the traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus according to claim 8, characterized in that in step C, the steaming time is 20 minutes.

10. The preparation method of the traditional Chinese medicine external application patch for strengthening the kidney and nourishing the fetus according to claim 8, characterized in that in step E, the medicine bag cools to 42 °C.

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