An insecticidal bait, its preparation method and application

Abstract

The application discloses an insecticidal bait and a preparation method and application thereof, and belongs to the technical field of daily chemicals. The main components of the insecticidal bait include an insecticidal component, an attracting component and a gelling agent, and the attracting component includes at least one of 2,3-butanediol, 3-methylbutyraldehyde, isobutyric acid, iso-valeric acid and malic acid. The preparation method of the insecticidal bait includes the following steps: S1, the insecticidal component and the attracting component are added and prepared into a water dispersion; S2, the gelling agent is added into the dispersion obtained in the step S1, stirring and heating are conducted, and the insecticidal bait is obtained after cooling. The application of the insecticidal bait in the prevention and treatment of pests. The insecticidal bait has the advantages of transparent or translucent soft gel appearance, color which can be adjusted according to needs by using water-soluble pigments, no obvious odor, long-lasting effect, easy processing, good formability and stability, and fly-killing effect meeting the national standard requirements.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of daily chemicals, in particular to a kind of insecticide bait and its preparation method and application. BACKGROUND

[0002] Flies are a common and widely distributed disease vector insect, which has many hazards. First, it can spread diseases. Studies have shown that flies can mechanically carry and spread many pathogens, mainly enteric infectious diseases such as dysentery, typhoid fever, and spinal cord gray pathogens. Flies have breeding and activity habits, not only pollute food, but also bring pathogens into the body with food, so they carry many pathogenic microorganisms that can harm humans.

[0003] There are many common methods to kill flies, such as directly killing them, using ultraviolet lamps or flypaper, and using insecticides to kill flies the most. Most insecticides exist in the form of sprays, which can pollute the environment while killing flies, and most insecticides on the market contain components that are harmful to the human body when inhaled. Using fly swatters, ultraviolet lamps or flypaper requires manpower and has poor results.

[0004] Insecticide bait is a highly efficient and low-toxicity product that contains fly-killing components and fly attractants. It kills flies through stomach poisoning and contact killing, is easy to use, and is an effective drug for killing flies. Fly bait has granular and gel types. Flies mainly use "licking" as the main feeding method, and a large amount of water is needed during the feeding process, so the gel type fly bait is more suitable for flies. In addition, household fly bait has more stringent requirements for the smell and appearance of the bait. The bait is transparent or translucent, has no obvious odor, and puts forward higher requirements for the selection of fly attractants in the bait.

[0005] Therefore, it is very important to develop an insecticide bait formula that has both attracting and killing functions. SUMMARY

[0006] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides an insecticide bait, which is a transparent gel type insecticide bait that can effectively improve the attracting effect and killing effect of the insecticide bait, and also reduce the odor of the insecticide bait.

[0007] The present application also provides a preparation method of the above-mentioned insecticide bait.

[0008] The present application also provides the application of the above-mentioned insecticide bait.

[0009] The first aspect of the present application provides an insecticide bait, the components of which include insecticidal components, attracting components and gelling agents.

[0010] The attracting component includes at least one of 2,3-butanediol, 3-methylbutanal, isobutyric acid, isovaleric acid and malic acid.

[0011] According to the embodiment of the first aspect of the present application, at least the following beneficial effects are achieved:

[0012] Due to the presence of the gel, the insecticidal bait of the present application appears as a transparent or translucent soft gel, and the color can be adjusted according to the need by using water-soluble pigments, so the appearance can meet the needs of different consumers.

[0013] The insecticidal bait of the present application has a good smell and no obvious odor due to the selection of components.

[0014] The insecticidal bait of the present application has a long-lasting effect, is easy to process, has good formability and stability, and the fly-killing effect meets the requirements of the national standard GB / T 13917.7.

[0015] The selection of the attracting component makes it compatible with the gelatinous insecticidal bait and has a good attracting effect, so the trapping rate of pests such as mosquitoes and flies can be improved.

[0016] According to some embodiments of the present application, the insecticidal component includes at least one of dinotefuran, imidacloprid and fipronil.

[0017] According to some embodiments of the present application, the mass percentage of the insecticidal component in the insecticidal bait is 0.01-1%.

[0018] When the insecticidal component is selected from the dinotefuran, the mass percentage of the insecticidal component in the insecticidal bait is 0.05-1%.

[0019] When the insecticidal component is selected from the imidacloprid, the mass percentage of the insecticidal component in the insecticidal bait is 0.1%-0.5%.

[0020] When the insecticidal component is selected from the fipronil, the mass percentage of the insecticidal component in the insecticidal bait is 0.01-0.1%.

[0021] Preferably, the insecticidal component is dinotefuran.

[0022] Preferably, the mass percentage of the insecticidal component in the insecticidal bait is about 0.15%.

[0023] According to some embodiments of the present application, the mass ratio of the attracting component to the insecticidal bait is 0.001-100 mg / kg.

[0024] When the attracting component includes the 2,3-butanediol, the mass ratio of the 2,3-butanediol to the insecticidal bait is 0.001-1 mg / kg.

[0025] When the attractant component comprises the 3-methylbutyraldehyde, the mass ratio of the 3-methylbutyraldehyde to the insect bait is 0.01 to 10 mg / kg.

[0026] When the attractant component comprises the isobutyric acid, the mass ratio of the isobutyric acid to the insect bait is 0.1 to 100 mg / kg.

[0027] When the attractant component comprises the isovaleric acid, the mass ratio of the isovaleric acid to the insect bait is 0.1 to 100 mg / kg.

[0028] When the attractant component comprises the malic acid, the mass ratio of the malic acid to the insect bait is 0.01 to 10 mg / kg.

[0029] According to some embodiments of the present application, the attractant component comprises 2,3-butanediol 0.001 to 1 mg / kg, 3-methylbutyraldehyde 0.01 to 10 mg / kg, isobutyric acid 0.1 to 30 mg / kg, isovaleric acid 0.1 to 40 mg / kg, and malic acid 0.1 to 10 mg / kg, in terms of mass ratio to the insect bait.

[0030] According to some embodiments of the present application, the attractant component comprises 2,3-butanediol 0.01 to 0.08 mg / kg, 3-methylbutyraldehyde 0.05 to 5 mg / kg, isobutyric acid 0.2 to 10 mg / kg, isovaleric acid 0.3 to 20 mg / kg, and malic acid 0.5 to 5 mg / kg, in terms of mass ratio to the insect bait.

[0031] According to some embodiments of the present application, the attractant component comprises 2,3-butanediol 0.05 mg / kg, 3-methylbutyraldehyde 0.1 mg / kg, isobutyric acid 0.3 mg / kg, isovaleric acid 0.4 mg / kg, and malic acid 1 mg / kg, in terms of mass ratio to the insect bait.

[0032] Preferably, the attractant component comprises 2,3-butanediol 0.05 mg / kg, 3-methylbutyraldehyde 0.1 mg / kg, isobutyric acid 0.3 mg / kg, isovaleric acid 0.4 mg / kg, and malic acid 1 mg / kg, in terms of mass ratio to the insect bait.

[0033] According to some embodiments of the present application, the gel agent comprises at least one of a refrigerant, carrageenan, and agar.

[0034] Preferably, the gel agent is carrageenan.

[0035] According to some embodiments of the present application, the gel agent accounts for 0.5% to 5% of the mass of the insect bait.

[0036] Preferably, the gel accounts for about 2% of the mass percentage of the insecticidal bait.

[0037] According to some embodiments of the present application, the main ingredients of the insecticidal bait further include at least one of a preservative, an antioxidant, a humectant, and a sweetener, and water.

[0038] According to some embodiments of the present application, the preservative includes at least one of potassium sorbate, sodium benzoate, lactic acid, and sodium lactate.

[0039] Preferably, the preservative is lactic acid and sodium lactate.

[0040] According to some embodiments of the present application, the preservative accounts for 0.05-0.5% of the mass percentage of the insecticidal bait.

[0041] Preferably, the preservative accounts for about 0.2% of the mass percentage of the insecticidal bait.

[0042] According to some embodiments of the present application, the mass ratio of the lactic acid and the sodium lactate in the preservative is 2:1.

[0043] According to some embodiments of the present application, the antioxidant includes sodium ascorbate.

[0044] According to some embodiments of the present application, the antioxidant accounts for 0.001-0.2% of the mass percentage of the insecticidal bait.

[0045] Preferably, the antioxidant accounts for about 0.05% of the mass percentage of the insecticidal bait.

[0046] According to some embodiments of the present application, the humectant includes glycerol.

[0047] According to some embodiments of the present application, the humectant accounts for 0.5-10% of the mass percentage of the insecticidal bait.

[0048] Preferably, the humectant accounts for about 8% of the mass percentage of the insecticidal bait.

[0049] According to some embodiments of the present application, the sweetener includes at least one of honey and sucrose.

[0050] Preferably, the sweetener is honey.

[0051] According to some embodiments of the present application, the sweetener accounts for 5-20% of the mass percentage of the insecticidal bait.

[0052] Preferably, the sweetener accounts for about 12% of the mass percentage of the insecticidal bait.

[0053] According to some embodiments of the present application, the water is deionized water.

[0054] According to some embodiments of the present application, the ingredients of the insecticidal bait further comprise a water-soluble pigment.

[0055] Preferably, the water-soluble pigment is a food-grade water-soluble orange dye.

[0056] According to some embodiments of the present application, the water-soluble pigment accounts for 0.01-0.04% of the mass percentage of the insecticidal bait.

[0057] The color can be adjusted as needed with a water-soluble pigment.

[0058] According to some embodiments of the present application, the ingredients of the insecticidal bait are as follows in terms of mass ratio to the insecticidal bait:

[0059]

[0060] Preferably, the main ingredients of the insecticidal bait are as follows in terms of mass ratio to the insecticidal bait:

[0061]

[0062] More preferably, the main ingredients of the insecticidal bait are as follows in terms of mass ratio to the insecticidal bait:

[0063]

[0064] According to some embodiments of the present application, the insecticidal bait is transparent or translucent soft gel.

[0065] Preferably, the insecticidal bait is in the form of a gel.

[0066] A second aspect of the present application provides a method for preparing the above-mentioned insecticidal bait, which comprises the following steps:

[0067] S1, preparing a water dispersion by adding the insecticidal ingredients and the attractant ingredients;

[0068] S2, adding a gelling agent to the dispersion obtained in step S1, stirring and heating, and then cooling to obtain the insecticidal bait.

[0069] According to some embodiments of the present application, the temperature of the heating in step S2 is 85-95°C.

[0070] Preferably, the temperature of the heating in step S2 is 87-92°C.

[0071] According to some embodiments of the present application, the holding time is about 8 minutes.

[0072] Preferably, the holding time is about 8 minutes.

[0073] According to some embodiments of the present application, the temperature to which the mixture is cooled in step S2 is about 40°C.

[0074] Preferably, the temperature to which the mixture is cooled in step S2 is about 40°C.

[0075] According to some embodiments of the present application, the preparation method further comprises adding a preservative, an antioxidant, a humectant, a sweetener and a water-soluble pigment in step S2.

[0076] A third aspect of the present application provides the use of the above-mentioned insect bait in controlling pests, which include at least one of flies, mosquitoes or cockroaches.

[0077] Preferably, the pests are flies.

[0078] Unless otherwise specified, "about" in the present application actually means that the error is within ±2%, for example, about 100 actually means 100 ± 2% x 100.

[0079] Other features and advantages of the present application will be set forth in the following description, and in part will become apparent to those skilled in the art from the description, or can be learned by practice of the present application. DETAILED DESCRIPTION

[0080] The concept and the resulting technical effects of the present application will be described below in conjunction with the embodiments, so as to fully understand the purposes, features and effects of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, but not all the embodiments. Based on the embodiments of the present application, other embodiments obtained by those skilled in the art without creative labor are within the scope of protection of the present application.

[0081] The CAS numbers of the raw materials in the present application are as follows:

[0082] Fipronil: 138261-41-3;

[0083] Fipronil: 138261-41-3;

[0084] Fipronil: 138261-41-3;

[0085] Fipronil: 138261-41-3;

[0086] Fipronil: 138261-41-3;

[0087] Isobutyric acid: 79-31-2;

[0088] Isovaleric acid: 503-74-2;

[0089] Malic acid: 636-61-3;

[0090] Carrageenan: 11114-20-8;

[0091] Lactic acid: 50-21-5;

[0092] Sodium lactate: 72-17-3;

[0093] Sodium ascorbate: 134-03-2;

[0094] Glycerol: 56-81-5.

[0095] Example 1

[0096] This example prepares an insecticidal bait, a total of 1 kg, the components are:

[0097]

[0098]

[0099] This example also provides a preparation method of the above-mentioned insecticidal bait, the specific proportion is shown in this example, and the steps are:

[0100] 1. Mix the insecticidal ingredients with deionized water, and stir until dissolved;

[0101] 2. Add the attractant ingredients 2,3-butanediol, 3-methylbutanal, isobutyric acid, isovaleric acid and malic acid; preservative lactic acid and sodium lactate; antioxidant sodium ascorbate; humectant glycerol; sweetener honey, stir until dissolved;

[0102] 3. Add the gelling agent carrageenan to step S2, stir and heat to 90°C, keep for 10 minutes, stop stirring, stop heating, pour into a dispensing container, cool to 50°C, seal and store.

[0103] Example 2

[0104] This example prepares an insecticidal bait, a total of 1 kg, the components are:

[0105]

[0106] This example also provides a preparation method of the above-mentioned insecticidal bait, the specific proportion is shown in this example, and the steps are:

[0107] 1. Mix the insecticidal ingredients with deionized water, and stir until dissolved;

[0108] 2. Add the attractant components isovaleric acid and malic acid; the preservative lactic acid and sodium lactate; the antioxidant sodium ascorbate; the humectant glycerol; the sweetener honey, stir until dissolved;

[0109] 3. Add the gelling agent carrageenan to step S2, stir and heat to 90°C, hold for 10 minutes, stop stirring, stop heating, pour into a dispensing container, cool to 50°C, seal and store.

[0110] Example 3

[0111] This example prepared an insecticidal bait, a total of 1 kg, the components are:

[0112]

[0113] This example also provides a preparation method of the above-mentioned insecticidal bait, the specific proportion is shown in this example, and the steps are:

[0114] 1. Mix the insecticidal components with deionized water, stir until dissolved;

[0115] 2. Add the attractant components isovaleric acid and malic acid; the preservative lactic acid and sodium lactate; the antioxidant sodium ascorbate; the humectant glycerol; the sweetener honey, stir until dissolved;

[0116] 3. Add the gelling agent carrageenan to step S2, stir and heat to 90°C, hold for 10 minutes, stop stirring, stop heating, pour into a dispensing container, cool to 50°C, seal and store.

[0117] Example 4

[0118] This example prepared an insecticidal bait, a total of 1 kg, the components are:

[0119]

[0120]

[0121] This example also provides a preparation method of the above-mentioned insecticidal bait, the specific proportion is shown in this example, and the steps are:

[0122] 1. Mix the insecticidal components with deionized water, stir until dissolved;

[0123] 2. Add the attractant components 2,3-butanediol, isovaleric acid and malic acid; the preservative lactic acid and sodium lactate; the antioxidant sodium ascorbate; the humectant glycerol; the sweetener honey, stir until dissolved;

[0124] 3. Add the gelling agent carrageenan to step S2, stir and heat to 90°C, hold for 10 minutes, stop stirring, stop heating, pour into a dispensing container, cool to 50°C, seal and store.

[0125] Example 5

[0126] This example prepared a kind of insecticide bait, total 1kg, component is:

[0127]

[0128] This example also provides the preparation method of the above-mentioned insecticide bait, and the specific proportion is shown in this example, and the steps are:

[0129] 1. the insecticidal component is mixed with deionized water, and stirred until dissolved;

[0130] 2. the attracting component 2, 3-butanediol, 3-methylbutyl aldehyde, isovaleric acid and malic acid;Preservative lactic acid and sodium lactate;Antioxidant sodium ascorbate;Moisturizing agent glycerol;Sweetener honey, stirring until dissolved;

[0131] 3. to step S2, add the gelling agent carrageenan dispersion, stirring and heating to 90 DEG C, keep for 10 minutes, stop stirring, stop heating, pour into the subpackaging container, cool to 50 DEG C, seal and store.

[0132] Example 6

[0133] This example prepared isobutyric acid:

[0134]

[0135]

[0136] This example also provides the preparation method of the above-mentioned insecticide bait, and the specific proportion is shown in this example, and the steps are:

[0137] 1. the insecticidal component is mixed with deionized water, and stirred until dissolved;

[0138] 2. the attracting component isobutyric acid;Preservative lactic acid and sodium lactate;Antioxidant sodium ascorbate;Moisturizing agent glycerol;Sweetener honey, stirring until dissolved;

[0139] 3. to step S2, add the gelling agent carrageenan dispersion, stirring and heating to 90 DEG C, keep for 10 minutes, stop stirring, stop heating, pour into the subpackaging container, cool to 50 DEG C, seal and store.

[0140] Comparative Example 1

[0141] This comparative example provides a kind of insecticide bait, which is different from example 1, and the insecticidal component is:

[0142] thiamethoxam 12g;

[0143] Comparative Example 2

[0144] This comparative example provides an insecticidal bait, which is different from Example 1 in that the attracting component is:

[0145]

[0146] Comparative Example 3

[0147] This comparative example provides an insecticidal bait, which is different from Example 1 in that the gel is:

[0148] Agar 20 g;

[0149] Comparative Example 4

[0150] This example provides an insecticidal bait, which is different from Example 1 in that the moisturizing agent is not included in the component.

[0151] Test Example

[0152] 1. Test of the killing effect of the insecticidal bait:

[0153] According to GB / T 13917.7 Indoor efficacy test and evaluation of health insecticides for pesticide registration Part 7: Insecticidal bait, each format is carried out.

[0154] Experimental procedure: square box device is used, and the attracting component of the insecticidal bait to be tested and fly feed are placed at opposite corners of the square box, and a culture dish containing soaked cotton balls is also placed. About 50 test insects are put in, and the number of dead insects in 24 hours is recorded. Three or more repetitions should be set for the test, and a normal feed blank control should be set. At the end of the experiment, the experimental device is cleaned.

[0155] Odor comfort rating standard: no obvious odor 4-5 points; slightly smelly, but not irritating 3-4 points; obvious odor 1-2 points.

[0156] Table 1 Odor comfort and trapping rate of attracting components in insecticidal bait

[0157]

[0158] According to the data in Table 1, the odor of the 1-6 attracting components is good, the effect of the 6 attracting component is not obvious, the odor of the 7-9 attracting components is too poor, and the preservation problem of fish meal extract is difficult to solve after a long time, so 6-9 are excluded.

[0159] 2. Performance test of the insecticidal bait:

[0160] (1) Mortality rate: the effect evaluation standard of GB / T 13917.7 is used to evaluate the effect and test the mortality rate.

[0161] Fly, A-class standard 100.0%, B-class standard ≥90.0%.

[0162] (2) Appearance: observed by naked eyes. It was transparent gel.

[0163] (3) Stability of gel: sealed in a box, stored at 54℃ for 14 days, and observed whether the gel had water separation or layering.

[0164] (4) Degradation rate of active ingredient (in the national standard, it is named as heat storage stability): according to item 5.5 of the national standard GB / T 24330, the test sample (with sealed package) was placed in a constant temperature box at (54±2)℃, and then tested within 24 hours according to the test method of active ingredient content, and the degradation rate was calculated. In the national standard, the active ingredient refers to the insecticidal ingredient, and the test method of active ingredient is selected from gas chromatography or liquid chromatography according to the different active ingredients. In the national standard, the degradation rate is required to be ≤10%.

[0165] (5) Transport resistance: sealed in a box, 10 boxes of fly bait were packed in a simulated transport machine, the vibration frequency was adjusted to 130-140 times per minute, the time was set to 10 hours, and the package was opened and observed.

[0166] (6) Mortality rate after 30 days of open storage: this test item evaluates the biological effect durability of fly bait, the box is opened, and the room temperature is placed for 30 days, and the effect is evaluated according to the national standard GB13917.7.

[0167] The above performance tests were carried out for multiple parallel tests, and the average value was calculated.

[0168] Table 3 Other performance test results of insecticidal bait

[0169]

[0170]

[0171] According to the results in Table 2, the average mortality rates of the insecticidal baits of examples 1-6 of the present application were all ≥90.0%, among which the average mortality rate of example 1 using the attractant components 2,3-butanediol, 3-methylbutanal, isobutyric acid, isovaleric acid and malic acid together was 100.0%, which met the A level standard. The heat storage stability was all ≤10%, which met the standard.

[0172] From appearance, the insecticidal baits of embodiments 1-6 of the present application are all orange yellow transparent or semi-transparent gels; regarding gel stability, embodiments 1-6 of the present application are all shaped and have no or little water precipitation, wherein comparative example 1 has water precipitation due to colloid, insects are more cautious to contact water, the ratio of insects contacting water and colloid is reduced, the contact probability of insects and the insecticidal bait is reduced, thus even if the insecticidal component in comparative example 1 is increased, it will cause slight decrease of lethality; regarding transportation resistance, the shapes of the insecticidal baits of embodiments 1-6 are all not fragmented, while comparative examples 1-2 all have 10% fragmentation, thus the insecticidal bait prepared by the present application is in transparent or semi-transparent gel state, has no obvious odor, has long-lasting effect, has good shaping property and stability, and the fly killing effect meets the requirements of national standards.

[0173] The embodiments of the present application are described above in detail, but the present application is not limited to the above embodiments, and various changes can be made within the knowledge of those skilled in the art without departing from the spirit of the present application. Furthermore, the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

Claims

1. An insecticidal bait, characterized in that, The insecticidal bait comprises an insecticidal component, an attractant component, and a gelling agent. The attractant component is composed of 2,3-butanediol, 3-methylbutanal, isobutyric acid, iso-valeric acid, and malic acid.

2. The insecticidal bait of claim 1, wherein The insecticidal component comprises at least one of dinotefuran, imidacloprid, and fipronil.

3. The insecticidal bait of claim 1, wherein The gelling agent comprises at least one of calcium alginate, carrageenan, and agar.

4. The insecticidal bait of claim 1, wherein The mass ratio of the attractant component to the insecticidal bait is 0.001-100 mg / kg.

5. The insecticidal bait of claim 1, wherein The mass percentage of the insecticidal component in the insecticidal bait is 0.01-1%.

6. The insecticidal bait of claim 1, wherein The mass percentage of the gelling agent in the insecticidal bait is 0.5%-5%.

7. The insecticidal bait of claim 1, wherein The insecticidal bait further comprises at least one of a preservative, an antioxidant, a humectant, and a sweetener.

8. The insecticidal bait of claim 7, wherein The preservative comprises at least one of potassium sorbate, sodium benzoate, lactic acid, and sodium lactate.

9. The insecticidal bait of claim 7, wherein The humectant comprises glycerol.

10. A method of preparing the insecticidal bait according to any one of claims 1 to 9, characterized in that, The preparation method comprises the following steps: S1, preparing a water dispersion of the insecticidal component and the attractant component; S2, adding the gelling agent to the dispersion obtained in step S1, stirring and heating, and then cooling to obtain the insecticidal bait.

11. The method of claim 10, wherein, The heating temperature in step S2 is 87-92°C.

12. The method of claim 10, wherein, The temperature after cooling in step S2 is 50°C.

13. Use of a pesticidal bait according to any one of claims 1 to 9 for the control of pests, characterized in that The pests comprise at least one of flies, mosquitoes, and cockroaches.

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