Method and apparatus for monitoring concentration of a reagent, electronic device, and computer-readable storage medium

Abstract

A method and apparatus, electronic device, and computer-readable storage medium for monitoring the concentration of a reagent. The method includes: obtaining a first concentration of a current reagent measured during filling of a current reagent having a preset concentration; obtaining a current volume of a carryover determined when filling and discharging a previous reagent; obtaining a second concentration of the current reagent measured during discharging of the current reagent, and determining a third concentration of the current reagent based on the preset concentration, the volume of the reagent bottle, and the current volume of the carryover; updating the current volume of the carryover based on the first concentration, the second concentration, and the volume of the reagent bottle (S104); and, when the third concentration is less than a preset concentration threshold, prompting a user to replace the current reagent and / or refresh the current reagent with a higher concentration reagent.

Description

Technical Field

[0001] The present disclosure relates to the field of tissue processing technology, and more particularly to a method for monitoring the concentration of an agent, an apparatus for monitoring the concentration of an agent, an electronic device, and a computer-readable storage medium. Background Art

[0002] When used in tissue processing, reagents need to meet specific concentration levels, so monitoring reagent concentration is a critical task. However, during tissue processing, reagents are often added to and removed from containers, which can leave residues in the containers and cause the concentration of the reagents to change, making it difficult to accurately determine the concentration of the reagents. Summary of the Invention

[0003] Embodiments of the present disclosure provide a method for monitoring the concentration of a reagent, a device for monitoring the concentration of a reagent, an electronic device for monitoring the concentration of a reagent, and a computer-readable storage medium, thereby enabling real-time monitoring of the reagent purity to remind the user to replace the reagent in a timely manner, thereby improving the quality of tissue processing.

[0004] In a first aspect of an embodiment of the present disclosure, a computer-implemented method for monitoring the concentration of a reagent is provided. The method includes: obtaining a first concentration of a current reagent measured during the period of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid circuit; obtaining a current capacity of a residue left in the container and the liquid circuit determined during the process of filling a previous reagent into the container and discharging the previous reagent from the container; obtaining a second concentration of the current reagent measured during the period of discharging the current reagent from the container into the reagent bottle via the liquid circuit, and after discharging the current reagent from the container into the reagent bottle, determining a third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle, and the current capacity of the residue; updating the current capacity of the residue left in the container and the liquid circuit based on the first concentration, the second concentration, and the capacity of the reagent bottle; and when the third concentration is less than a preset concentration threshold, reminding a user to replace the current reagent and / or refresh the current reagent with a high-concentration reagent.

[0005] In an embodiment, after the current reagent is discharged from the container into the reagent bottle, determining the third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle and the current capacity of the legacy includes: after filling the container with the current reagent, determining the concentration of the current reagent in the container based on the preset concentration, the capacity of the reagent bottle and the current capacity of the legacy; after the current reagent is discharged from the container into the reagent bottle, controlling the reagent bottle to be replenished with the current reagent having the preset concentration; and determining the third concentration of the current reagent in the reagent bottle based on the concentration of the current reagent in the container, the capacity of the reagent bottle, the preset concentration and the current capacity of the legacy.

[0006] In an embodiment, determining the concentration of the current reagent in the container based on the preset concentration, the capacity of the reagent bottle and the current capacity of the carryover includes: using the formula Vaf = (Vb-Vco) × Cbf to calculate the capacity of the main component of the current reagent in the container; and using the formula Caf = Vaf ÷ Vb to calculate the concentration of the current reagent in the container; wherein Vaf represents the capacity of the main component of the current reagent in the container, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the current reagent in the container.

[0007] In an embodiment, determining the third concentration of the current reagent in the reagent bottle based on the concentration of the current reagent in the container, the capacity of the reagent bottle, the preset concentration and the current capacity of the carryover includes: using the formula Vad = (Vb-Vco) × Caf + Vco × Cbf to calculate the capacity of the main component of the current reagent in the reagent bottle; and using the formula Cad = Vad ÷ Vb to calculate the third concentration of the current reagent in the reagent bottle; wherein Vad represents the capacity of the main component of the current reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the current reagent in the container, and Cad represents the third concentration.

[0008] In an embodiment, updating the current capacity of the legacy remaining in the container and the liquid circuit based on the first concentration, the second concentration and the capacity of the reagent bottle includes: calculating the updated capacity of the legacy using the formula Vco'=(CDF-CDD) / CDF×Vb; and replacing the current capacity of the legacy with the updated capacity of the legacy; wherein Vco' represents the updated capacity of the legacy, CDD represents the second concentration of the current reagent, CDF represents the first concentration of the current reagent, and Vb represents the capacity of the reagent bottle.

[0009] In an embodiment, the present reagent is selected from the group consisting of ethanol and xylene.

[0010] In a second aspect of an embodiment of the present disclosure, a device for monitoring the concentration of a reagent is provided. The device includes: a first acquisition module for obtaining a first concentration of a current reagent measured during the process of filling a current reagent with a preset concentration from a reagent bottle to a container via a liquid path; a second acquisition module for obtaining the current capacity of a legacy determined in the process of filling a previous reagent into the container and discharging the previous reagent from the container and leaving in the container and the liquid path; a determination module for obtaining a second concentration of the current reagent measured during the process of discharging the current reagent from the container to the reagent bottle via the liquid path, and after discharging the current reagent from the container to the reagent bottle, determining a third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle and the current capacity of the legacy; an update module for updating the current capacity of the legacy left in the container and the liquid path based on the first concentration, the second concentration and the capacity of the reagent bottle; and a reminder module for reminding a user to replace the current reagent when the third concentration is less than a preset concentration threshold, and / or a refresh module for refreshing the current reagent with a high concentration reagent.

[0011] In an embodiment, the determination module includes: a first determination unit for determining the concentration of the current reagent in the container based on a preset concentration, the capacity of the reagent bottle, and the current capacity of the carryover after the current reagent is filled in the container; a control unit for controlling the reagent bottle to be replenished with the current reagent having a preset concentration after the current reagent is discharged from the container into the reagent bottle; and a second determination unit for determining a third concentration of the current reagent in the reagent bottle based on the concentration of the current reagent in the container, the capacity of the reagent bottle, the preset concentration, and the current capacity of the carryover.

[0012] In an embodiment, the first determination unit includes: a first calculation submodule for calculating the capacity of the main component of the current reagent in the container using the formula Vaf = (Vb-Vco) × Cbf; and a second calculation submodule for calculating the concentration of the current reagent in the container using the formula Caf = Vaf ÷ Vb; wherein Vaf represents the capacity of the main component of the current reagent in the container, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the current reagent in the container.

[0013] In an embodiment, the second determination unit includes: a third calculation submodule for calculating the capacity of the main component of the current reagent in the reagent bottle using the formula Vad = (Vb-Vco) × Caf + Vco × Cbf; and a fourth calculation submodule for calculating the third concentration of the current reagent in the reagent bottle using the formula Cad = Vad ÷ Vb; wherein Vad represents the capacity of the main component of the current reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the current reagent in the container, and Cad represents the third concentration.

[0014] In an embodiment, the update module includes: a third determination unit, used to determine the updated capacity of the legacy using the formula Vco'=(CDF-CDD) / CDF×Vb; a replacement unit, used to replace the current capacity of the legacy with the updated capacity of the legacy; wherein Vco' represents the updated capacity of the legacy, CDD represents the second concentration of the current reagent, CDF represents the first concentration of the current reagent, and Vb represents the capacity of the reagent bottle.

[0015] In an embodiment, the present reagent is selected from the group consisting of ethanol and xylene.

[0016] In a third aspect of the present disclosure, an electronic device is provided. The electronic device includes: a processor; and a memory having instructions executable by the processor stored therein. When the instructions are executed by the processor, the processor performs the method according to any embodiment of the present disclosure.

[0017] In a fourth aspect of the present disclosure, a non-transitory computer-readable medium is provided. The computer-readable medium includes processor-executable instructions stored therein. When the instructions are executed by the processor, the processor performs the method according to any embodiment of the present disclosure.

[0018] Using a method and apparatus for monitoring the concentration of a reagent, a first concentration of the current reagent measured during the process of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid circuit can be obtained, and a current volume of a residue remaining in the container and the liquid circuit determined during the process of filling a previous reagent into the container and discharging the previous reagent from the container can be obtained, and then a second concentration of the current reagent measured during the process of discharging the current reagent from the container into the reagent bottle via the liquid circuit can be obtained, and a third concentration of the current reagent after discharging the current reagent from the container into the reagent bottle can be determined based on the preset concentration, the capacity of the reagent bottle, and the current volume of the residue, and the current volume of the residue remaining in the container and the liquid circuit can be updated based on the first concentration, the second concentration, and the capacity of the reagent bottle, and when the third concentration is less than a preset concentration threshold, a user is reminded to replace the current reagent. Thus, the volume of the residue remaining in the container can be dynamically updated, so that the concentration of the reagent can be accurately determined in real time to remind the user to replace the reagent in a timely manner, thereby improving the quality of tissue processing. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to clearly illustrate the technical solutions of the embodiments of the present disclosure, a brief description of the drawings used in the embodiments is given below. Obviously, the drawings described below are only part of the embodiments of the present disclosure, and it is clear that those skilled in the art can derive other drawings based on these drawings without making any creative efforts.

[0020] Figure 1 is a flow chart of a method for monitoring the concentration of a reagent according to some embodiments of the present disclosure.

[0021] Figure 2 FIG. 4 is a flow chart illustrating a process of obtaining the concentration of a reagent according to some embodiments of the present disclosure.

[0022] Figure 3 is a block diagram of an apparatus for monitoring the concentration of a reagent according to some embodiments of the present disclosure.

[0023] Figure 4 is a block diagram of an electronic device according to some embodiments of the present disclosure. DETAILED DESCRIPTION

[0024] Exemplary embodiments will now be described in detail, examples of which are illustrated in the accompanying drawings. In the following description, when referring to the drawings, like numbers in different figures represent the same or similar elements unless otherwise indicated. The embodiments described in the following exemplary embodiments are not intended to represent all embodiments consistent with the present invention. Rather, they are merely examples of apparatus and methods consistent with certain aspects of the present invention, as detailed in the appended claims.

[0025] The embodiment of the present disclosure provides a method for monitoring the concentration of a reagent. The reagent is used for tissue processing and can be ethanol and xylene. Figure 1 As shown, the method includes steps 101-105.

[0026] In step S101 , a first concentration of a current reagent measured during filling of a current reagent having a preset concentration from a reagent bottle into a container via a fluid path is acquired.

[0027] In this embodiment, when the reagent is filled from the reagent bottle into the container via the liquid path, the concentration of the reagent can be measured by the density meter.

[0028] In step S102 , the current volume of the residue remaining in the container and the fluid path determined during the process of filling the container with the previous reagent and draining the previous reagent from the container is acquired.

[0029] When reagent is filled into container and discharged from container via liquid circuit, usually carryover will be left in container and liquid circuit.Under the situation that carryover already exists in container, when reagent is filled into container and discharged from container via liquid circuit, the concentration of reagent may change.In order to monitor the concentration of reagent, obtain the current capacity of the carryover left in container and liquid circuit.The current capacity of the carryover left in container and liquid circuit is by previous reagent being filled into container and previous reagent being discharged from container via liquid circuit, can thus determine the current capacity of carryover in the process that previous reagent is filled into container and previous reagent is discharged from container.

[0030] In step S103, a second concentration of the current reagent measured during the discharge of the current reagent from the container to the reagent bottle via the liquid path is obtained, and after the current reagent is discharged from the container to the reagent bottle, a third concentration of the current reagent is determined based on the preset concentration, the capacity of the reagent bottle, and the current capacity of the carryover.

[0031] After the container is filled with the reagent, the concentration of the reagent in the container changes relative to the concentration of the reagent during the filling due to the current volume of the residue left in the container and the fluid path. In addition, due to the current volume of the residue left in the container and the fluid path, after the reagent is discharged from the container to the reagent bottle via the fluid path, the concentration of the reagent in the reagent bottle is no longer the same as the original concentration of the reagent in the reagent bottle.

[0032] In certain embodiments, can determine the 3rd concentration of the current reagent after current reagent is discharged to reagent bottle from container as described below.After current reagent is filled up container, the current capacity determination of the current reagent in the container based on the capacity of preset concentration, reagent bottle and the legacy left in the container.After current reagent is discharged to reagent bottle from container, replenish reagent bottle with the current reagent of preset concentration.Based on the concentration of the current reagent in the container, the capacity of reagent bottle, preset concentration and the legacy left in the container, determine the 3rd concentration of the current reagent in the reagent bottle.

[0033] In some embodiments, after the container is filled with the reagent, the volume of the main component of the reagent in the container can be determined according to the following formula:

[0034] Vaf=(Vb-Vco)×Cbf

[0035] Wherein, Vaf represents the volume of the main component of the reagent in the container, Vco represents the current volume of the residue left in the container, Vb represents the volume of the reagent bottle, and Cbf represents the preset concentration.

[0036] Based on the volume of the main component and the volume of the reagent bottle, the concentration of the reagent in the container can be calculated using the following formula:

[0037] Caf=Vaf÷Vb

[0038] Wherein, Caf represents the current concentration of the reagent in the container.

[0039] In the container, the reagent can be used for tissue processing. After the tissue processing, the reagent can be discharged from the container back to the reagent bottle, and the reagent bottle will be replenished with the current reagent having a preset concentration to ensure that the reagent bottle is full of the current reagent, that is, the current reagent has the capacity of the reagent bottle. Then, the concentration of the reagent in the reagent bottle is determined as follows.

[0040] Use the following formula to calculate the volume of the main component of the reagent in the reagent bottle:

[0041] Vad=(Vb-Vco)×Caf+Vco×Cbf

[0042] Wherein, Vad represents the capacity of the main component of the current reagent in the reagent bottle.

[0043] Use the following formula to calculate the volume of the reagent in the reagent bottle:

[0044] Cad=Vad÷Vb

[0045] Wherein, Cad represents the concentration of the reagent in the reagent bottle.

[0046] In step S104, the current volume of the residue remaining in the container and the fluid path is updated based on the first concentration, the second concentration, and the volume of the reagent bottle.

[0047] During the process of filling and draining the reagent into and from the container via the fluid circuit, the volume of the carryover remaining in the container and the fluid circuit may vary.

[0048] In some embodiments, after a cycle of filling and draining reagents into and from a container via a fluid circuit, the current volume of the carryover remaining in the container and the fluid circuit is replaced with an updated volume of the carryover, which can be determined as follows: Then, during the next cycle of filling and draining reagents into and from the container via a fluid circuit, the concentration of the reagent can be monitored in real time based on the updated volume of the carryover.

[0049] Based on the concentration of the reagent measured during the drain, the concentration of the reagent measured during the fill, and the volume of the reagent bottle, the updated volume of the carryover is determined. For example, the updated volume of the carryover can be calculated using the following formula:

[0050] Vco'=(CDF-CDD) / CDF×Vb

[0051] Wherein, Vco' represents the updated capacity of the carryover, CDD represents the concentration of the reagent measured during draining, CDF represents the concentration of the reagent measured during filling, and Vb represents the capacity of the reagent bottle.

[0052] The above formula can be derived using the following formula:

[0053] CDD=((Vco×CW)+CDF×(Vb-Vco))÷Vb

[0054] Wherein, CW represents the water concentration. Assuming CW = 0, CDD = (CDF × (Vb - Vco)) ÷ Vb, from which the above formula can be obtained.

[0055] In step S105 , when the third concentration is less than the preset concentration threshold, the user is prompted to replace the current reagent and / or refresh the current reagent with a high-concentration reagent.

[0056] The reagents used for tissue processing need to meet a specific concentration level. For example, the concentration of the reagent should be greater than a preset concentration threshold, otherwise the tissue processing cannot be effectively achieved.

[0057] To ensure the effectiveness of tissue processing, when the reagent does not meet a specific concentration level, the user may be reminded to replace the reagent with a reagent having a concentration higher than a preset concentration threshold, or the reagent may be refreshed with a high concentration reagent.

[0058] The user may be alerted in various ways, for example, by an audio signal, a visual signal, a vibration signal or other signals.

[0059] The method for monitoring reagent concentration can be applied in a variety of scenarios. For example, the method can be applied to tissue processing. During tissue processing, a tissue dehydrator is an important device for achieving tissue dehydration, and reagents are required during tissue dehydration. Utilizing the method for monitoring reagent concentration, the tissue dehydrator can monitor the concentration of the reagent used for tissue dehydration in real time, allowing the user to be reminded to replace the reagent at the appropriate time. This ensures that the reagent concentration meets the dehydration requirements of the tissue and avoids reagent waste.

[0060] Using a method for monitoring the concentration of a reagent, a first concentration of the current reagent measured during the process of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid circuit can be obtained, and a current volume of a residue remaining in the container and the liquid circuit determined during the process of filling a previous reagent into the container and discharging the previous reagent from the container can be obtained, and then a second concentration of the current reagent measured during the process of discharging the current reagent from the container into the reagent bottle via the liquid circuit can be obtained, and a third concentration of the current reagent after discharging the current reagent from the container into the reagent bottle can be determined based on the preset concentration, the capacity of the reagent bottle, and the current volume of the residue, and the current volume of the residue remaining in the container and the liquid circuit can be updated based on the first concentration, the second concentration, and the capacity of the reagent bottle, and when the third concentration is less than a preset concentration threshold, a user is reminded to replace the current reagent. Thus, the volume of the residue remaining in the container can be dynamically updated, so that the concentration of the reagent can be accurately determined in real time to remind the user to replace the reagent in a timely manner, thereby improving the quality of tissue processing.

[0061] Figure 2 FIG. 4 is a flow chart illustrating a process of obtaining the concentration of a reagent according to some embodiments of the present disclosure.

[0062] In step S201 , all required reagents with corresponding preset concentrations are prepared.

[0063] In step S202, a protocol is selected to run.

[0064] The protocol dictates how to use reagents in tissue processing, for example, the timing of filling and draining reagents from reagent bottles into containers via fluid circuits, the order of filling and draining reagents from containers, and the like.

[0065] In step S203, the algorithm parameters are initialized.

[0066] For example, the current volume of the residue left in the container and the fluid path is initialized to 0, and the volume of the reagent bottle is assigned a value according to the actual situation. The algorithm parameters can be stored in a buffer.

[0067] In step S204, reagents are filled into the container via the fluid circuit according to the selected protocol.

[0068] In step S205 , the density of the reagent during the filling is measured by the densitometer during the filling of the reagent.

[0069] In step S206, it is determined whether the container is filled with reagent.

[0070] In step S207, the concentration of the reagent in the container is calculated.

[0071] Calculate the concentration of the reagent in the container by using the following formula:

[0072] Vaf=(Vb-Vco)×Cbf;

[0073] Caf=Vaf÷Vb;

[0074] Wherein, Vaf represents the volume of the main component of the reagent in the container, Vco represents the current volume of the carryover, Vb represents the volume of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the reagent in the container.

[0075] In the first round of the protocol, the current volume of the carryover has an initial value, and in subsequent rounds of the protocol, the current volume of the carryover has a value determined in a round prior to the current round. For example, in the first round of the protocol, the value of the volume of the carryover is determined, and in the second round of the protocol, the concentration of the reagent is calculated using the value of the volume of the carryover determined in the first round.

[0076] In step S208, tissue processing is performed.

[0077] In step S209 , the reagent is discharged from the container to the reagent bottle via the liquid path.

[0078] In step S210 , the concentration of the reagent during the discharge is measured by a densitometer during the discharge of the reagent.

[0079] In step S211, it is determined whether the reagent is drained from the container.

[0080] After the reagent is discharged from the container into the reagent bottle, if the reagent bottle is no longer full because of residues left in the container and the fluid path, the reagent bottle is topped up with a reagent having a preset concentration to ensure that the amount of reagent reaches the capacity of the reagent bottle.

[0081] In step S212, the current concentration of the reagent in the reagent bottle is calculated.

[0082] Calculate the current concentration of the reagent in the reagent bottle by using the following formula:

[0083] Vad=(Vb-Vco)×Caf+Vco×Cbf;

[0084] Cad=Vad÷Vb;

[0085] Among them, Vad represents the capacity of the main component of the reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the reagent in the container, and Cad represents the current concentration of the reagent in the reagent bottle.

[0086] In step S213, the current volume of the residue remaining in the container and the fluid circuit is updated.

[0087] Update the current capacity of the legacy in the container by using:

[0088] Vco'=(CDF-CDD) / CDF×Vb

[0089] Wherein, CDD represents the concentration of the reagent during discharge, CDF represents the concentration of the reagent during filling, and Vb represents the capacity of the reagent bottle, and Vco' represents the updated capacity of the carryover.

[0090] In step S214, it is determined whether the protocol is fully implemented. If so, the process is completed, otherwise step S215 is executed.

[0091] In step S215, the next reagent for tissue processing is selected.

[0092] In the process of obtaining the concentration of the reagent, the volume of the carryover remaining in the container is dynamically adjusted in each round, so that a more accurate concentration of the reagent can be obtained.

[0093] The embodiments of the present disclosure also provide a device for monitoring the concentration of a reagent. Figure 3 As shown, the apparatus includes a first acquisition module 301 , a second acquisition module 302 , a determination module 303 , an update module 304 , a reminder module 305 and / or a refresh module 306 .

[0094] The first acquisition module 301 is used to acquire a first concentration of a current reagent measured during the process of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid path.

[0095] The second obtaining module 302 is used to obtain the current volume of the residue remaining in the container and the fluid path determined during the process of filling the previous reagent into the container and discharging the previous reagent from the container.

[0096] The determination module 303 is used to obtain the second concentration of the current reagent measured during the discharge of the current reagent from the container to the reagent bottle via the liquid path, and after the current reagent is discharged from the container to the reagent bottle, determine the third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle and the current capacity of the carryover.

[0097] The updating module 304 is configured to update the current volume of the residue remaining in the container and the fluid path based on the first concentration, the second concentration, and the volume of the reagent bottle.

[0098] The reminder module 305 is configured to remind the user to replace the current reagent when the third concentration is less than a preset concentration threshold.

[0099] The refreshing module 306 is used to refresh the current reagent with a high concentration reagent.

[0100] By using a device for monitoring the concentration of a reagent, a first concentration of the current reagent measured during the process of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid circuit can be obtained, and a current volume of a residue remaining in the container and the liquid circuit determined during the process of filling a previous reagent into the container and discharging the previous reagent from the container can be obtained, and then a second concentration of the current reagent measured during the process of discharging the current reagent from the container into the reagent bottle via the liquid circuit can be obtained, and a third concentration of the current reagent after discharging the current reagent from the container into the reagent bottle can be determined based on the preset concentration, the capacity of the reagent bottle, and the current volume of the residue, and the current volume of the residue remaining in the container and the liquid circuit can be updated based on the first concentration, the second concentration, and the capacity of the reagent bottle, and when the third concentration is less than a preset concentration threshold, a user is reminded to replace the current reagent. Thus, the volume of the residue remaining in the container can be dynamically updated, so that the concentration of the reagent can be accurately determined in real time to remind the user to replace the reagent in a timely manner, thereby improving the quality of tissue processing.

[0101] In certain embodiments, determination module 303 comprises: a first determining unit, a control unit and a second determining unit. The first determining unit is used for after current reagent is filled up container, based on the current capacity of preset concentration, the capacity of reagent bottle and carryover, determining the concentration of the current reagent in the container. The control unit is used for after current reagent is discharged from container to reagent bottle, controlling reagent bottle to replenish with the current reagent with preset concentration. The second determining unit is used for based on the current capacity of the concentration of the current reagent in the container, the capacity of reagent bottle, preset concentration and carryover, determining the 3rd concentration of the current reagent in the reagent bottle.

[0102] In some embodiments, the first determination unit includes: a first calculation submodule and a second calculation submodule. The first calculation submodule is used to calculate the capacity of the main component of the current reagent in the container using the formula Vaf = (Vb-Vco) × Cbf. The second calculation submodule is used to calculate the concentration of the current reagent in the container using the formula Caf = Vaf ÷ Vb. Wherein, Vaf represents the capacity of the main component of the current reagent in the container, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the current reagent in the container.

[0103] In some embodiments, the second determination unit includes: a third calculation submodule and a fourth calculation submodule. The third calculation submodule is used to calculate the capacity of the main component of the current reagent in the reagent bottle using the formula Vad = (Vb-Vco) × Caf + Vco × Cbf. The fourth calculation submodule is used to calculate the third concentration of the current reagent in the reagent bottle using the formula Cad = Vad ÷ Vb. Wherein, Vad represents the capacity of the main component of the current reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the current reagent in the container, and Cad represents the third concentration.

[0104] In some embodiments, the update module includes: a third determination unit, a fourth determination unit, and a replacement unit. The third determination unit is configured to determine the updated capacity of the legacy using the formula Vco' = (CDF - CDD) / CDF × Vb; wherein Vco' represents the updated capacity of the legacy, CDD represents the second concentration of the current reagent, CDF represents the first concentration of the current reagent, and Vb represents the capacity of the reagent bottle. The replacement unit is configured to replace the current capacity of the legacy with the updated capacity of the legacy.

[0105] In some embodiments, the present reagent is selected from the group consisting of ethanol and xylene.

[0106] Regarding the device in the above embodiment, the specific manner in which each module performs operations has been described in detail in the embodiment of the method and will not be described in detail here.

[0107] The present disclosure also provides a kind of equipment for monitoring the concentration of reagent.Equipment may include a densitometer, a buffer, a controller and a processor.The densitometer is configured to measure the density of reagent during filling, and to measure the second concentration of reagent during discharge.The controller is configured to control reagent to be filled into container from reagent bottle via liquid path, and to control reagent to be discharged into reagent bottle from container via liquid path.In certain embodiments, the controller may also be configured to control reagent bottle to replenish with the reagent with preset concentration.The buffer may be configured to store the parameter of the current capacity that comprises preset concentration, water concentration, the capacity of reagent bottle, the legacy left in container and in. The processor may be configured to: obtain the concentration of the reagent measured by the densitometer during the filling of the reagent from the reagent bottle into the container; obtain parameters including the current volume of the residue left in the container, the volume of the reagent bottle, the water concentration, and the preset concentration from the buffer; obtain the concentration of the reagent measured during the discharge period; after the reagent is discharged from the container into the reagent bottle, determine the concentration of the reagent based on the preset concentration, the volume of the reagent bottle, and the current volume of the residue; determine the updated current volume of the residue based on the concentration measured during the filling period, the concentration measured during the discharge period, and the volume of the reagent bottle; and replace the current volume of the residue stored in the buffer with the updated current volume of the residue. In addition, the processor is configured to remind a user to replace the reagent and / or refresh the current reagent with a higher concentration reagent when the concentration of the reagent is less than a preset concentration threshold.

[0108] Figure 4 FIG is an example diagram of the internal structure of an electronic device according to an embodiment of the present disclosure. Figure 4 As shown, the electronic device includes a processor and a memory connected via a system bus. The processor is used to provide computing and control capabilities to support the operation of the entire electronic device. The memory may include a non-volatile storage medium and an internal memory. The non-volatile storage medium stores an operating system and a computer program. The computer program is executed by the processor to implement the method for monitoring the concentration of a reagent according to an embodiment of the present disclosure. The internal memory provides a cached operating environment for the operating system and the computer program in the non-volatile storage medium. The electronic device may be a mobile phone, a tablet computer, a personal digital assistant, a wearable device, etc.

[0109] Each module in the apparatus for monitoring the concentration of a reagent according to an embodiment of the present disclosure may be implemented in the form of a computer program. When the computer program is executed by a processor, the steps of the method according to an embodiment of the present disclosure are implemented.

[0110] The present disclosure also provides a computer-readable storage medium including computer-executable instructions. When the computer-executable instructions are executed by one or more processors, the one or more processors perform the steps of the method for monitoring the concentration of a reagent according to the present disclosure.

[0111] A computer program product comprising instructions is provided. When the instructions are executed on a computer, the computer performs the method for monitoring the concentration of a reagent according to an embodiment of the present disclosure.

[0112] As used herein, any reference to memory, storage, database, or other medium may include nonvolatile and / or volatile memory. Nonvolatile memory may include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable programmable ROM (EEPROM), or flash memory. Volatile memory may include random access memory (RAM), which may be used as external cache memory. By way of illustration and not limitation, RAM is available in various forms, such as static RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), synchronous link DRAM (SLDRAM), RAMbus direct RAM (RDRAM), direct memory bus dynamic RAM (DRDRAM), and RAMbus dynamic RAM (RDRAM).

[0113] The preferred embodiments of the present disclosure are described in detail above in conjunction with the accompanying drawings. However, the present disclosure is not limited to the specific details of the above embodiments. Within the technical concept of the present disclosure, various simple modifications can be made to the technical solutions of the present disclosure, and these simple modifications all fall within the scope of protection of the present disclosure.

[0114] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. To avoid unnecessary repetition, the present disclosure will not further describe various possible combinations.

[0115] In addition, the various embodiments of the present disclosure may be arbitrarily combined, and as long as they do not violate the concept of the present disclosure, they should also be regarded as the contents disclosed by the present disclosure.

Claims

1. A computer-implemented method for monitoring the concentration of a reagent, comprising: acquiring a first concentration of the current reagent measured during the process of filling the current reagent having a preset concentration from the reagent bottle into the container via the fluid path; obtaining a current volume of carryover remaining in the container and the fluid circuit determined during the process of filling the container with a previous reagent and draining the container with a previous reagent; obtaining a second concentration of the current reagent measured during discharge of the current reagent from the container into the reagent bottle via the fluid path, and determining a third concentration of the current reagent after the current reagent is discharged from the container into the reagent bottle based on a preset concentration, a capacity of the reagent bottle, and a current capacity of the carryover; updating the current volume of the residue remaining in the container and the fluid path based on the first concentration, the second concentration, and the volume of the reagent bottle; as well as When the third concentration is less than the preset concentration threshold, the user is reminded to replace the current reagent and / or refresh the current reagent with a high-concentration reagent.

2. The method according to claim 1, wherein After the current reagent is discharged from the container into the reagent bottle, determining a third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle, and the current capacity of the carryover includes: After the container is filled with the current reagent, determining the concentration of the current reagent in the container based on the preset concentration, the capacity of the reagent bottle, and the current capacity of the carryover; After the current reagent is discharged from the container into the reagent bottle, controlling the reagent bottle to be replenished with the current reagent having a preset concentration; and A third concentration of the current reagent in the reagent bottle is determined based on the concentration of the current reagent in the container, the capacity of the reagent bottle, the preset concentration, and the current capacity of the carryover.

3. The method according to claim 2, wherein: Determining the current concentration of the reagent in the container based on the preset concentration, the volume of the reagent bottle, and the current volume of the carryover includes: Calculate the volume of the main component of the current reagent in the container using the formula Vaf = (Vb - Vco) x Cbf; and Use the formula Caf = Vaf ÷ Vb to calculate the concentration of the current reagent in the container; Wherein, Vaf represents the capacity of the main component of the current reagent in the container, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the current reagent in the container.

4. The method according to claim 2, wherein: Determining a third concentration of the current reagent in the reagent bottle based on the current concentration of the reagent in the container, the capacity of the reagent bottle, the preset concentration, and the current capacity of the carryover includes: Calculate the volume of the main component of the current reagent in the reagent bottle using the formula Vad = (Vb - Vco) x Caf + Vco x Cbf; and Use the formula Cad = Vad ÷ Vb to calculate the third concentration of the current reagent in the reagent bottle; Among them, Vad represents the capacity of the main component of the current reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the current reagent in the container, and Cad represents the third concentration.

5. The method according to any one of claims 1 to 4, wherein Updating the current volume of the residue remaining in the container and the fluid path based on the first concentration, the second concentration, and the volume of the reagent bottle includes: Calculate the updated capacity of the legacy using the formula Vco' = (CDF - CDD) / CDF × Vb; Replace the current capacity of the legacy with the updated capacity of the legacy; Wherein, Vco' represents the updated capacity of the carryover, CDD represents the second concentration of the current reagent, CDF represents the first concentration of the current reagent, and Vb represents the capacity of the reagent bottle.

6. The method according to any one of claims 1 to 4, wherein The present reagent is selected from the group consisting of ethanol and xylene.

7. A device for monitoring the concentration of a reagent, comprising a first acquiring module for acquiring a first concentration of a current reagent measured during the period of filling a current reagent having a preset concentration from a reagent bottle into a container via a liquid path; a second obtaining module for obtaining a current volume of a residue remaining in the container and the fluid path determined during a process of filling a previous reagent into the container and draining the previous reagent from the container; a determination module configured to obtain a second concentration of the current reagent measured during discharge of the current reagent from the container to the reagent bottle via the liquid path, and determine a third concentration of the current reagent after the current reagent is discharged from the container to the reagent bottle based on a preset concentration, a capacity of the reagent bottle, and a current capacity of the carryover; an updating module for updating a current volume of the residue remaining in the container and the fluid path based on the first concentration, the second concentration, and the volume of the reagent bottle; as well as a reminder module, configured to remind the user to replace the current reagent when the third concentration is less than a preset concentration threshold, and / or a refresh module, configured to refresh the current reagent with a high-concentration reagent.

8. The device according to claim 7, wherein The modules to be determined include: a first determining unit for determining, after the container is filled with the current reagent, a concentration of the current reagent in the container based on a preset concentration, a capacity of the reagent bottle, and a current capacity of the carryover; a control unit for controlling the current reagent to be discharged from the container into the reagent bottle after the current reagent is discharged from the container into the reagent bottle, and controlling the reagent bottle to be replenished with the current reagent having a preset concentration; and The second determining unit is configured to determine a third concentration of the current reagent in the reagent bottle based on the concentration of the current reagent in the container, the capacity of the reagent bottle, the preset concentration, and the current capacity of the carryover.

9. The device according to claim 8, wherein The first determining unit includes: A first calculation submodule is configured to calculate the capacity of the main component of the current reagent in the container using the formula Vaf=(Vb-Vco)×Cbf; and A second calculation submodule is used to calculate the concentration of the current reagent in the container using the formula Caf=Vaf÷Vb; Wherein, Vaf represents the capacity of the main component of the current reagent in the container, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, and Caf represents the concentration of the current reagent in the container.

10. The device according to claim 8, wherein The second determining unit includes: A third calculation submodule is configured to calculate the capacity of the main component of the current reagent in the reagent bottle using the formula Vad=(Vb-Vco)×Caf+Vco×Cbf; and a fourth calculation submodule, configured to calculate a third concentration of the current reagent in the reagent bottle using a formula Cad=Vad÷Vb; Among them, Vad represents the capacity of the main component of the current reagent in the reagent bottle, Vco represents the current capacity of the carryover, Vb represents the capacity of the reagent bottle, and Cbf represents the preset concentration, Caf represents the concentration of the current reagent in the container, and Cad represents the third concentration.

11. The device according to any one of claims 7 to 10, wherein: Update modules include: A third determining unit is configured to determine the updated capacity of the legacy using the formula Vco'=(CDF-CDD) / CDF×Vb; a replacement unit for replacing the current capacity of the legacy with the updated capacity of the legacy; Wherein, Vco' represents the updated capacity of the carryover, CDD represents the second concentration of the current reagent, CDF represents the first concentration of the current reagent, and Vb represents the capacity of the reagent bottle.

12. The device according to any one of claims 7 to 10, wherein: The present reagent is selected from the group consisting of ethanol and xylene.

13. An electronic device comprising: processor; A memory for storing instructions executable by a processor, wherein when the instructions are executed by the processor, the processor is caused to perform the method according to any one of claims 1 to 6.

14. A device for monitoring the concentration of a reagent, comprising a densitometer, a buffer, a controller, and a processor; in, The controller is configured to control the current reagent having a preset concentration to be filled from the reagent bottle into the container via the liquid path, and to control the current reagent to be discharged from the container into the reagent bottle via the liquid path; The densitometer is configured to measure a first density of the current reagent during filling and a second density of the current reagent during draining; The buffer is configured to store parameters including a preset concentration, a capacity of a reagent bottle, a current capacity of a residue remaining in the container and the fluid path, and a preset concentration threshold; The processor is configured to: obtaining a first concentration of a current reagent measured during the filling period; Obtaining from the buffer the preset concentration, the water concentration, the volume of the reagent bottle, the preset concentration threshold, and the current volume of the residue remaining in the container and the fluid path; obtaining a second concentration of the current reagent measured during the discharge period; After the current reagent is discharged from the container into the reagent bottle, determining a third concentration of the current reagent based on the preset concentration, the capacity of the reagent bottle, and the current capacity of the carryover; Determining an updated current volume of the legacy remaining in the container and the fluid path based on the first concentration, the second concentration, and the volume of the reagent bottle, and replacing the current volume of the legacy stored in the buffer with the updated current volume of the legacy; as well as When the third concentration is less than the preset concentration threshold, the user is reminded to replace the current reagent and / or refresh the current reagent with a high-concentration reagent.

15. A non-transitory computer-readable medium having instructions stored thereon, which, when executed by a processor, are operable to perform the operations of the method according to any one of claims 1-6.

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