Moisturizing antibacterial composition

Abstract

A transparent antimicrobial composition comprises water, alcohol, a humectant and a sensory oil. The method for preparing the transparent antimicrobial composition comprises combining the sensory oil and the humectant to form a first phase; combining water and the alcohol to form a second phase; combining the first phase and the second phase to form a third phase; and adding a neutralizer to the third phase, thereby forming the antimicrobial composition.

Description

Technical Field

[0001] The present invention discloses an antibacterial composition, in particular, a transparent moisturizing antibacterial composition. The transparent moisturizing antibacterial composition comprises water, alcohol, a moisturizer and a sensory oil. Background Art

[0002] Consumers are increasingly concerned about microbial and viral contamination. Therefore, hygiene has been one of the most important attributes required by consumers. Consumers expect products that will provide the desired hygiene properties. Consumers around the world use different types of antimicrobial compositions to disinfect various surfaces, including hard surfaces, such as countertops, floors, and furniture; soft and porous surfaces, such as clothing, carpets, and upholstery; and personal surfaces, such as skin and hair. Many microorganisms, such as bacteria and viruses, are found on such surfaces. It is desirable to keep these surfaces free of bacteria to minimize the risk of illness.

[0003] Many antibacterial products are commercially available. Some are provided as gels, liquids or liquid sprays containing at least 60% by weight or more ethanol. Although such products are known to produce good antibacterial benefits after application, some consumers avoid using high ethanol-based products because such products may dry out the skin, weaken the epidermal barrier and accelerate the aging process. In the current environment, consumers may use antibacterial products on their bodies throughout the day, thus increasing the likelihood of dry skin.

[0004] Therefore, there is a continuing need to develop an antibacterial composition that provides excellent antimicrobial and antiviral benefits while being safe and mild enough to be used throughout the day at any time of day. In view of consumer demand, there is increasing interest in developing an antibacterial composition that also delivers soothing and moisturizing benefits when applied topically. Summary of the invention

[0005] In various aspects, moisturizing antimicrobial compositions are disclosed.

[0006] The transparent antimicrobial composition comprises: water; alcohol; humectant; and sensory oil.

[0007] A method for preparing a transparent antimicrobial composition comprises: combining a sensory oil with a moisturizer to form a first phase; combining water and an alcohol to form a second phase; combining the first phase and the second phase to form a third phase; and adding a neutralizer to the third phase to form the antimicrobial composition.

[0008] These and other features and characteristics are described in more detail below. DETAILED DESCRIPTION

[0009] Disclosed herein is an antibacterial composition. The antibacterial composition is a transparent composition having non-sticky sensory properties. The antibacterial composition can be in any form, but is preferably in the form of a transparent liquid spray. The antibacterial composition provides moisturizing to the surface to which it is applied. For example, when the composition is applied to human skin, the antibacterial composition does not dry the user's skin, but rather moisturizes and disinfects the user's skin. The antibacterial composition can provide less than or equal to 8 hours of moisturizing to the surface to which it is applied. The antibacterial composition can also provide antimicrobial and antiviral protection against bacteria, viruses, and fungi. The antibacterial composition includes water, alcohol, a moisturizer, and a sensory oil. It was unexpectedly found that the antibacterial composition provides moisturizing without stickiness after application. This is an unexpected benefit because antibacterial compositions generally require the use of an anti-adhesive agent to reduce the stickiness typically associated with the application of the antibacterial composition.

[0010] The antimicrobial composition may be substantially free of anti-adhesives. Substantially free of anti-adhesives means that the composition contains less than 2% by weight of anti-adhesives, preferably less than 1% by weight of anti-adhesives, more preferably less than 0.5% by weight of anti-adhesives, even more preferably less than 0.1% by weight of anti-adhesives, and even more preferably 0% by weight of anti-adhesives. The weight percentages (wt%) mentioned throughout this article refer to the wt% in the total composition.

[0011] The antimicrobial composition advantageously provides moisturizing and disinfecting benefits to the surface to which it is applied. As used herein, a disinfecting or antimicrobial composition refers to a composition that can kill bacteria or inhibit bacterial growth. The antimicrobial composition may be substantially free of emulsifiers. The antimicrobial composition may be transparent or translucent, preferably the antimicrobial composition is transparent. Substantially free of emulsifiers means that the composition contains less than 2% by weight of emulsifiers, preferably less than 1% by weight of emulsifiers, more preferably less than 0.5% by weight of emulsifiers, even more preferably less than 0.1% by weight of emulsifiers, and even more preferably 0% by weight of emulsifiers.

[0012] The antimicrobial composition comprises water in an amount of 8 to 30 wt%, preferably 10 to 25 wt%, more preferably 10 to 20 wt%.

[0013] Alcohol can be used as the antimicrobial agent in the composition. When using alcohol as the antimicrobial agent, the antimicrobial composition comprises 60 to 80 wt %, preferably 62 to 75 wt %, more preferably 65 to 75 wt % of the alcohol, including all values ​​and ranges contained therein. The alcohol can include a variety of alcohols, including but not limited to ethanol, propanol (n-propanol), isopropanol or a combination thereof. The level of alcohol present in the antimicrobial composition can be adjusted based on the purity percentage of the alcohol. For example, if 92% ethanol is used, the ethanol can be used in an amount of 70 to 80 wt %, such as 75 wt %. Optionally, the alcohol can include chloroxylenol. A preferred alcohol can be denatured SD-40 ethanol.

[0014] The antimicrobial composition may optionally include one or more additional antimicrobial agents. The optional additional antimicrobial agent may be selected from terpenes, essential oils, or cationic oils having a solubility in water of less than 2000 parts per million (ppm) at 25°C. Examples of aromatic essential oils that can be used in the antimicrobial composition disclosed herein include amyl salicylate, carvacrol, cymene (e.g., p-cymene), dihydroeugenol, eugenol, hexyl eugenol, hexyl salicylate, isoeugenol, methyl eugenol, methyl isoeugenol, methyl salicylate, tert-butyl cresol, thymol, coumarin, ylang ylang, ylang ylang, copaiba oil, and vanillin. Examples of non-aromatic essential oils of terpenoids include cedane, eucalyptol, citral (including geranyl and neral), citronellal, nitronelol, eucalyptol (i.e., 1,8 cineole), p-dihydrolinalool, dihydromyrcenol (DH myrcenol), farnesol, geraniol, hexylcinnamaldehyde, hydroxycitronellol, hydroxycitronellal, isocitral, limonene, preferably d-limonene, linalool, longifolene, menthol, nerol, nerolactone diols, pinenes such as α-pinene, phellandrene, terpinines such as α-terpinene and γ-terpinene, terpineols such as γ-terpinene and terpine-4-ol, and tetrahydromyrcenol (THM).

[0015] Preferred cationic oils include quaternary ammonium cationic vegetable oils and charged aminopolydimethylsilanes having the formula (CH3)3-Si[Si(CH3)2-O]-[Si(CH3)-((CH2)3-NH-(CH2)2-NH2)-O]2-Si-(CH3)3. It is preferred that the solubility of these additional antimicrobial agents is less than 2000 ppm at 25°C. For example, the additional antimicrobial agent may be terpineol, thymol, eugenol, borneol, limonene or a combination thereof. Preferred additional antimicrobial agents may be terpineol, thymol or eugenol, or a combination thereof.

[0016] Other types of optional additional antimicrobial agents include silver compounds. The silver compound may contain silver ions, for example, the silver ions may be selected from silver nitrate, silver acetate, silver oxide, silver sulfate or a combination thereof. Preferably, the silver compound is silver nitrate.

[0017] More specifically, the silver compound optionally used in the composition is one or more water-soluble silver (I) compounds having a relative humidity of at least 1.0×10 -4 Silver ion solubility in mol / L (in water at 25°C). As referred to herein, silver ion solubility is a value derived from the solubility product (Ksp) in water at 25°C, which is a well-known parameter reported in many sources. More specifically, silver ion solubility [Ag+] (a value given in mol / L) can be calculated using the following formula:

[0018] [Ag+]=(Ksp·x) (1 / (x+1)) ,

[0019] where Ksp is the solubility product of the compound of interest in water at 25°C, and x represents the number of moles of silver ions per mole of compound. -4 Silver (I) compounds having a silver ion solubility of 1 mol / L are ideal for use in the present invention.

[0020] Among the silver compounds, those contemplated for use in the present invention are silver oxide, silver nitrate, silver acetate, silver sulfate, silver benzoate, silver salicylate, silver carbonate, silver citrate and silver phosphate, or a combination thereof, preferably wherein the silver compound is silver nitrate, silver acetate, silver oxide, silver sulfate or a combination thereof.

[0021] When present, the additional antimicrobial agent can be included in an amount of 0.05 to 2 weight percent, such as 0.1 to 2 weight percent, of the total antimicrobial composition, including all values ​​and ranges subsumed therein.

[0022] Sensory oils can be used in antibacterial compositions to help leave a non-sticky feel on the user's skin after applying the composition. The antibacterial composition comprises sensory oils in an amount of 0.01 to 10% by weight, preferably 0.5 to 5% by weight (including all values ​​and ranges contained therein). The sensory oils may comprise soluble sensory oils. The sensory oils desired for use in the antibacterial compositions disclosed herein must meet the following criteria: the sensory oils must be liquid, the sensory oils must be soluble in at least 75 / 25 or higher ratios of EtOH / water, which reflects the solubility in the final composition to obtain a clear final antibacterial composition, and the sensory oils must have no solubility for water.

[0023] The soluble sensory oil may comprise a dicarboxylic acid ester, a lactic acid ester, a fatty alcohol, a (poly)propylene glycol fatty ether, or a combination thereof. The sensory oil may also comprise a mixture of a soluble sensory oil and an insoluble sensory oil, provided that the combination is soluble in the final use composition. For example, the soluble sensory oil may comprise diisopropyl adipate, diisopropyl sebacate, or diethylhexyl malate, lauryl lactate, myristyl lactate, cetyl lactate, isostearyl alcohol, PPG14 butyl ether, PPG15 stearyl ether, or a combination thereof.

[0024] Further combinations of the above materials with oils (such as triglycerides, such as capric / caprylic triglycerides, or soybean oil, or fatty esters, such as isopropyl myristate or isopropyl palmitate) are also within the scope, provided that they are soluble and form a transparent end-use composition. The latter does not limit the choice of insoluble oils that can be used in the compositions disclosed herein. That is, other insoluble oils can be used, provided that when combined with the selected sensory oil of the composition of the present invention, the insoluble oil becomes soluble when mixed with the end-use composition. Any combination of sensory oils used in the antimicrobial composition should not affect the transparency of the antimicrobial composition.

[0025] In addition to those previously described herein, the antibacterial composition may contain other ingredients in addition, including but not limited to skin benefit agents, fragrances, preservatives, surfactants, fixatives, sunscreens, chelating agents, thickeners, humectants, structurants, dyes or colorants, or combinations thereof. For example, various colorants may be optionally used in the antibacterial composition. When present, the amount of the colorant may be 0.00001 to 0.005% by weight of the antibacterial composition, such as 0.0001 to 0.003% by weight, such as 0.001% by weight of the antibacterial composition, including all values ​​and ranges contained therein.

[0026] For example, wetting agent can be optionally used in antibacterial composition to provide additional moisturizing properties to composition. It is desirable that such wetting agent for antibacterial composition can include water-soluble polyols, such as propylene glycol, dipropylene glycol, polypropylene glycol (such as PPG-9), polyethylene glycol, hydroxypropyl sorbitol, sorbitol, hexylene glycol, 1,3-butylene glycol, 1,4-butylene glycol, 1,2-octanediol, 1,2-hexanediol, isopentyl glycol, 1,2,6-hexanetriol, ethoxylated glycerol, propoxylated glycerol and combinations thereof. Most preferably, glycerol, butylene glycol, propylene glycol, polyethylene glycol, sorbitol, polyglycerol, isopentyl glycol, hyaluronic acid or combinations thereof. Wetting agent can be present in an amount of 1 to 10 % by weight, preferably 2 to 9 % by weight, more preferably 3 to 8 % by weight of the antibacterial composition.

[0027] The antibacterial composition may optionally contain a surfactant, such as a cationic surfactant. When used, the cationic surfactant is limited to that it should be able to be used for topical application on human skin. The cationic surfactant may include a branched or straight chain alkyl trimethyl ammonium compound, an alkanoyl trimethyl ammonium compound, or a combination thereof. The alkanoyl trimethyl ammonium compound includes lauroyl ethyl trimethyl ammonium methyl sulfate, palmitoyl ethyl trimethyl ammonium methyl sulfate, stearyl ethyl trimethyl ammonium methyl sulfate, carnitine, palmitoyl carnitine, a combination thereof, and the like. The trimethyl ammonium compound used may be an alkyl trimethyl ammonium compound, including cetyl trimethyl ammonium chloride, cetyl trimethyl ammonium bromide, myristyl trimethyl ammonium chloride, myristyl trimethyl ammonium bromide, behenyl trimethyl ammonium methyl sulfate, coconut oil trimethyl ammonium methyl sulfate, behenyl trimethyl ammonium chloride, behenyl trimethyl ammonium bromide, stearyl trimethyl ammonium chloride, stearyl trimethyl ammonium bromide, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, a combination thereof, and the like. For the avoidance of doubt, the cationic surfactant used in the antimicrobial compositions disclosed herein may consist essentially of or consist of any combination of the above-mentioned surfactants.

[0028] With regard to cationic surfactants comprising dimethylammonium compounds, such compounds include dialkyldimethylammonium compounds such as distearyldimethylammonium chloride, didecyldimethylammonium chloride, dicocoyldimethylammonium chloride, combinations thereof, and the like. Other dimethylammonium compounds suitable for use include benzethonium chloride and / or benzalkonium chloride. The dimethylammonium and trimethylammonium compounds used herein are intended to include salts thereof, especially chlorides and bromides thereof.

[0029] Polyquaternium materials may also be used, and may include materials such as Polyquaternium-6, Polyquaternium-10, Polyquaternium-16, Polyquaternium-45, Polyquaternium-28, Polyquaternium-53, Polyquaternium-67, acrylamidopropyl-trimethylammonium chloride / acrylate (or acrylamide) copolymer, combinations thereof, and the like.

[0030] The amount of cationic surfactant (i.e., cationic trimethylammonium, dimethylammonium) and / or polyquaternium material used in the composition is typically 0.007 to 5 wt %, and preferably 0.01 to 3 wt %, most preferably 0.05 to 1 wt %, based on the total weight of the composition, including all values ​​and ranges subsumed therein.

[0031] When trimethylammonium and dimethylammonium surfactants are used, they are typically used in a weight ratio of 1:99 to 99:1, preferably 30:70 to 70:30, most preferably 40:60 to 60:40.

[0032] The antimicrobial composition may also optionally contain a sunscreen and a light stabilizer, provided that the type and amount of the sunscreen and light stabilizer used do not affect the transparency of the composition. The sunscreen and light stabilizer used include, for example, octyl methoxycinnamate (OMC), ethylhexyl salicylate, phenylbenzimidazole sulfonic acid (Ensulizole), ethylhexyl p-methoxycinnamate (available as Parsol Avobenzone (butyl methoxydibenzoylmethane) (available as Parsol The materials of this type include benzophenone-3 (also known as oxybenzone) and benzophenone-4 (also known as sulisophenone). Still others may include bis-ethylhexyloxyphenol methoxyphenol triazine, 2-ethylhexyl-2-cyano-3,3-diphenyl-2-propionic acid, drometrizole trisiloxane, 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate, 2-ethylhexyl-2-hydroxybenzoate or a combination thereof. Inorganic sunscreen actives may be used, such as finely divided titanium dioxide (preferably with a particle size of less than 150 nanometers (nm), and most preferably less than 100 nm) and zinc oxide, polyethylene and various other polymers are also suitable sunscreen agents. Other suitable sunscreens include para-aminobenzoic acid (PABA), octyl dimethyl-PABA, 2-ethoxyethyl p-methoxycinnamate, benzophenone-1, benzophenone-2, benzophenone-6, benzophenone-8, benzophenone-9, benzophenone-12, methyl homosalicylate, menthyl anthranilate, benzophenone-4, triethanolamine salicylate, terephthalylidene dicamphor sulfonic acid, bisoctriazole, bis-ethylhexyloxyphenol methoxyphenyl triazine, disodium phenyl dibenzimidazole tetrasulfonate (bisdisulizole), diometriazole trisiloxane, octyl triazone, isotrizinol, polysilicone-15, isopentenyl-4-methoxycinnamate, or combinations thereof. Octocrylene may also be used. When present, the amount of sunscreen or photostabilizer can be 0.001 to 20 weight percent, preferably 0.005 to 15 weight percent, more preferably 0.01 to 0.2 weight percent, even more preferably 0.1 weight percent of the antimicrobial composition, including all values ​​and ranges subsumed therein.

[0033] Ideally, the optional skin benefit agents used in the antibacterial composition disclosed herein include niacinamide (vitamin B3), tocopherol (vitamin E), aloe, alpha-hydroxy acids and esters, beta-hydroxy acids and esters, hydroxyethyl urea, polyhydroxy acids and esters, creatine, hydroquinone, tert-butyl hydroquinone, mulberry, hyaluronic acid and its salts (including but not limited to its Na+ and K+ salts), extracts, licorice extracts, resorcinol derivatives or combinations thereof. Such skin benefits may include but are not limited to wound healing benefits, such as healing, dryness reduction, anti-grey yellowing, etc. For example, the skin benefit agent may be sodium hyaluronate. Based on the total weight of the antibacterial composition, such benefit agents including sodium hyaluronate can be present in an amount of 0.0001 to 10% by weight, such as 0.001 to 6.5% by weight, such as 0.01 to 3.5% by weight, and for example 0.01% by weight, and include all values ​​and ranges contained therein.

[0034] Other optional water-soluble skin benefit agents include acids, such as amino acids, such as arginine, valine, histidine, lysine, aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, isoleucine, leucine, tyrosine or phenylalanine. Other vitamins can be used, such as vitamin B2, pyridine amide, panthenol (vitamin B5), vitamin B6, vitamin C, combinations thereof, etc. Derivatives (usually referring to some that have been developed or obtained from other substances) can also be used, especially water-soluble derivatives of these vitamins. For example, vitamin C derivatives, such as ascorbyl tetraisopalmitate, magnesium ascorbyl phosphate and ascorbyl glycosides can be used alone or in combination with each other. Nicotinamide derivatives, such as nicotinamide adenine dinucleotide (NADH) and nicotinamide adenine dinucleotide phosphate (NADPH), can be used alone or in combination with each other. Other skin benefit agents that can be used include 4-ethylresorcinol, extracts such as sage, aloe, green tea, sugar cane, citrus, grape seed, thyme, chamomile, yarrow, cucumber, licorice, rosemary extracts, or combinations thereof. Electrolytes such as NaCl and / or KCl, MgCl2 can also be used. When present in the compositions disclosed herein, the total amount of optional water-soluble benefit agents (including mixtures) can be 0.0001 to 10 weight %, preferably 0.001 to 6.5 weight %, and most preferably 0.01 to 3.5 weight %, based on the total weight of the antibacterial composition, and including all values ​​and ranges contained therein.

[0035] It is also within the scope of the antimicrobial composition to optionally include an oil-soluble benefit agent. Illustrative examples of the types of oil-soluble benefit agents that can be optionally used in the antimicrobial compositions disclosed herein include components such as stearic acid, vitamins such as vitamins A, D, E and K (and their oil-soluble derivatives).

[0036] Other optional oil-soluble benefit agents used include resorcinols and resorcinol derivatives, such as 4-hexylresorcinol, 4-phenylethylresorcinol, 4-cyclopentylresorcinol, 4-cyclohexylresorcinol, 4-isopropylresorcinol, or combinations thereof. In addition, 5-substituted resorcinols can be used, such as 4-cyclohexyl-5-methylbenzene-1,3-diol, 4-isopropyl-5-methylbenzene-1,3-diol, combinations thereof, and the like. 5-substituted resorcinols and their synthesis are described in commonly assigned U.S. Published Patent Application No. 2016 / 0000669A1.

[0037] Even other oil-soluble benefit agents that can be used include omega-3 fatty acids, omega-6 fatty acids, climbazole, magnolol, honokiol, farnesol, ursolic acid, myristic acid, geranylgeraniol, oleyl betaine, cocoyl hydroxyethyl imidazoline, hexanoyl sphingosine, 12-hydroxystearic acid, petroselinic acid, conjugated linoleic acid, stearic acid, palmitic acid, lauric acid, terpineol, thymol essential oil components,, solubilizing aids selected from limonene, pinene, camphene, cymene, citronellol, citronellal, geraniol, nerol, linalool, rhodiolaol, borneol, isoborneol, menthone, camphor, safrole, isosafrole, eugenol, isoeugenol, tea tree oil, eucalyptus essential oil, peppermint oil, neem oil, lemongrass oil, orange oil, bergamot oil or a combination thereof.

[0038] Another optional oil-soluble beneficial agent that can be used is a retinoic acid precursor. The retinoic acid precursor can be retinol, retinal, retinyl ester, retinyl propionate, retinyl palmitate, retinyl acetate, or a combination thereof. Retinyl propionate, retinyl palmitate, and combinations thereof are generally preferred. Yet another retinoic acid precursor that can be used is provided by Molecular Design International under the trade name Commercially available hydroxyanisole retinoic acid ester. It can be used in combination with any of the oil-soluble benefit agents described herein.

[0039] When the optional (i.e., 0.0 to 1.5 wt %) oil-soluble benefit agent is used in the antimicrobial composition, it is typically present in an amount of 0.001 to 1.5 wt %, and such as 0.05 to 1.2 wt %, for example 0.2 to 0.5 wt %, based on the total weight of the final use composition, including all values ​​and ranges subsumed therein.

[0040] Film formers can be used in the antimicrobial composition. Although optional, such agents can help the composition adhere to the surface to which it is applied. Film formers include those with hydrophilic properties, and they include materials containing polyvinyl pyrrolidone (PVP), acrylates, acrylamides, and copolymers thereof. Deposition agents such as organosiloxanes and polyquaternium-7 (Merquat from Lubrizol) can also be used. TMS polymers). When used, these agents comprise 0.001 to 1 wt % of the antimicrobial composition, including all values ​​and ranges subsumed therein.

[0041] Other optional components that can be used in the composition are mosquito repellents, such as eucalyptus oil, lavender oil, N,N-diethyl-m-toluamide (DEET), combinations thereof, and the like. Even other ingredients that can be used include octopirox (piroctone), zinc pyrithione, chloroxylenol, triclosan, cetylpyridinium chloride, and silver compounds, including silver oxide, silver nitrate, silver sulfate, silver phosphate, silver carbonate, silver acetate, silver benzoate, combinations thereof, and the like. If used, these other components typically comprise 0.001 to 1.6% by weight of the antimicrobial composition, preferably 0.01 to 1.2% by weight, including all values ​​and ranges subsumed therein.

[0042] Optionally, preservatives can be used in the antibacterial composition disclosed herein. When used, the exemplary preservatives used include sodium benzoate, iodopropynyl butylcarbamate, phenoxyethanol, hydroxyacetophenone, ethylhexylglycerol, methylparaben, propylparaben, imidazolidinyl urea, sodium dehydroacetate, dimethyl-dimethyl (DMDM) hydantoin and benzyl alcohol, or a combination thereof. Other preservatives suitable for use include sodium dehydroacetate, chlorphenesin ether and decanediol. Preservatives are preferably used in an amount of 0.01% to 2.0% by weight of the total weight of the antibacterial composition, including all values ​​and ranges contained therein. It is also preferred to have a preservative system with a single hydroxyacetophenone or a mixture with other preservatives.

[0043] Fragrance, fixative, sunscreen (such as titanium dioxide or glycol distearate), chelating agent can be optionally included in the antibacterial composition.Possible chelating agents include but are not limited to ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), diethylenetriaminepentaacetic acid pentasodium, N-(hydroxyethyl)-ethylenediaminetriacetic acid trisodium, the acid form of EDTA, sodium thiocyanate, methylglycine diacetic acid trisodium salt, glutamic acid diacetic acid tetrasodium and phytic acid, preferably wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS) or its combination.Each of these substances can be present in an amount of about 0.03% by weight to about 3% by weight, preferably about 0.1% by weight to about 2.6% by weight of the gross weight of the antibacterial composition, including all values ​​and ranges contained therein.

[0044] In order to adjust the viscosity of the antibacterial spray composition, a small amount of thickener is optionally included within the composition. Thickeners classified as polysaccharides are optionally used. Examples include fibers, starches, natural / synthetic gums, and celluloses. Representative starches are chemically modified starches, such as hydroxypropyl starch sodium phosphate and starch octenyl succinate aluminum. Tapioca starch is generally preferred, as is maltodextrin. Gums include xanthan gum, tara gum, sclerotium gum, pectin, karaya gum, gum arabic, agar, guar gum (including gum arabic guar gum), carrageenan, alginates, and combinations thereof. Celluloses include hydroxypropyl cellulose, hydroxypropyl methylcellulose (e.g., Ashland's BENECEL TM E10M), ethyl cellulose, sodium carboxymethyl cellulose (cellulose gum / carboxymethyl cellulose) and cellulose (e.g., cellulose microfibrils, cellulose nanocrystals or microcrystalline cellulose). Sources of cellulose microfibrils include secondary cell wall materials (e.g., wood pulp, cotton), bacterial cellulose and primary cell wall materials. Preferably, the source of the primary cell wall material is selected from the parenchyma tissue from fruits, roots, bulbs, tubers, seeds, leaves and combinations thereof; more preferably selected from citrus fruits, tomato fruits, peach fruits, pumpkin fruits, kiwi fruits, apple fruits, mango fruits, beets, beetroots, turnips, parsnips, corn, oats, wheat, peas and combinations thereof; and even more preferably selected from citrus fruits, tomato fruits and combinations thereof. The most preferred source of primary cell wall material is parenchyma tissue from citrus fruits. Citrus fiber, such as can be obtained from Those obtained as AQ Plus can also be used as a source of cellulose microfibrils. The cellulose source can be surface-modified by any known method, including those described in Colloidal Polymer Science, Kalia et al., "Nanofibrillated cellulose: surface modification and potential applications" (2014), Vol. 292, pp. 5-31.

[0045] Other thickeners that may be included may include hydrophobically modified cross-linked polymers. Synthetic polymers are effective thickeners. Possible thickeners include cross-linked polyacrylates, such as carbomers, such as ASHLAND TM 980 Carbomer (cross-linked polymer of acrylic acid), acrylates copolymer, acrylates / acrylates (C 10 -C 30 ) alkyl acrylate crosspolymers, such as series, such as Ultrez 20 and ETD 2020, which are commercially available from Lubrizol with the INCI name Acrylates / C10-30 Alkyl Acrylate Crosspolymer. From Lubrizol Still other polymers in the series may include Ultrez 10, Ultrez 21, etc. Polyacrylamide such as 305 and taurate copolymer EG and AVC, the copolymers are identified by their respective INCI names as sodium acrylate / sodium acryloyldimethyl taurate and acryloyldimethyl taurate / vinyl pyrrolidone copolymer. Still other thickening polymers may include synthetic polymers such as acrylate-based polymers commercially available from Seppic and sold under the name Simulgel INS 100. Calcium carbonate, fumed silica, and magnesium aluminum silicate may also be used.

[0046] When used, the amount of thickener can be the scope of 0.001 to 5 weight % of the antibacterial composition. Maltodextrin, xanthan gum and carboxymethyl cellulose are conventional preferred thickeners. Other conventionally desired thickeners are dilinoleyl / dimethyl carbonate copolymers, stearyl alkyl ammonium hectorite, spermaceti (cetyl stearyl, stearyl) fatty alcohol, tara gum, polyquaternium salt 32 and / or 37, pentaerythritol tetrastearate or its combination.

[0047] The antimicrobial composition may optionally contain an emulsifier. The emulsifier may be selected from those having: C condensed with about 2 to about 100 moles of ethylene oxide or propylene oxide per mole of hydrophobe; 10 -C 20 Fatty alcohol or acid hydrophobe; C2-C 10 Alkylphenols; Mono- and di-fatty acid esters of ethylene glycol; f; Sorbitan, mono- and di-C8-C 20 Fatty acids; and polyoxyethylene sorbitan, or a combination thereof. Alkyl polyglycosides and sugar fatty amides (eg, methyl glucamide) can also be used as nonionic emulsifiers.

[0048] Preferred emulsifiers generally have an HLB (hydrophile-lipophile balance) of 7.5 to 28, and preferably 8 to 25, most preferably 9 to 20, including all ranges subsumed therein, for example, nonionic emulsifiers may include polysorbate 20 (Tween 20), polyoxyethylene (20) sorbitan monooleate (Tween 80). When present, the emulsifier may be present in an amount of 0 to 1% by weight, for example 1% by weight, including all values ​​and ranges subsumed therein.

[0049] The antimicrobial composition may additionally contain a neutralizing agent, such as sodium hydroxide, potassium hydroxide, triethanolamine, ammonium, arginine, tromethamine, aminomethyl propanol sold by Angus as AMP 95, AMP-Ultra PC1000, AMP-Ultra PC2000, AMP-Ultra PC3000, tetrahydroxypropylethylenediamine also known as Neutrol TE from BASF, diisopropanolamine, triisopropanolamine, or a combination thereof. The neutralizing agent may be present in an amount of 0 to 1 wt %, such as 0.1 to 0.75 wt %, such as 0.2 to 0.5 wt %, including all values ​​and ranges subsumed therein.

[0050] Regarding packaging, the antibacterial composition can be packaged in a spray bottle, a squeeze bottle, or provided as an impregnated wetting agent on a cotton swab, a wipe, a towel, a cosmetic substrate sheet (such as those described in US 6,294,182B1), etc. Because the viscosity is increased by a thickener, the antibacterial composition gels and can be provided to consumers as a gel composition in a squeeze bottle. The spray bottle can also be metal, and the antibacterial composition can be provided by conventional aerosol packaging technology, and includes those technologies that utilize air-in-bag discharge tanks, mechanisms, and actuators. It is also within the scope of the antibacterial composition to include a foaming agent (e.g., zwitterionic and / or amphoteric surfactants) so that the antibacterial composition can be discharged as a foam.

[0051] The antimicrobial composition should be provided with instructions for applying (e.g., squeezing or spraying) the composition onto a surface (e.g., skin) to kill bacteria and reduce viral activity. The antimicrobial composition may be provided in a biodegradable package, and the package used is preferably refillable or reusable, biodegradable, and / or at least 50%, preferably at least 100%, made of post-consumer recycled resin. The antimicrobial composition may be in the form of a liquid or a gel, preferably the antimicrobial composition is in the form of a liquid, such as a liquid spray antimicrobial composition.

[0052] As used herein, skin means skin including arms (including underarms), face, feet, neck, chest, hands, legs, buttocks and scalp (including hair). Disinfection as used herein refers to at least 2 bacterial logarithmic kills and at least 2 viral logarithmic inactivations (both achieved) within less than 3 minutes after topical application to the surface, preferably at least 3 bacterial logarithmic kills and at least 3 viral logarithmic inactivations. As used herein, combination means the total weight of, for example, cetrimonium chloride plus benzalkonium chloride. Skin benefit agents refer to ingredients suitable for improving skin properties. Surfaces as used herein include skin or inanimate surfaces, such as desktops, computer monitors, door handles, toilet seats, shopping cart handles or even clothing. Surfaces also mean fur including animals, such as the fur of dogs and cats. As used herein, surfaces preferably refer to human skin, and especially the skin on the face and hands.

[0053] The antimicrobial composition can be a home care composition, such as a laundry spray composition suitable for spraying clothes and interior decorations that need to be disinfected. The home care composition can also be an antimicrobial kitchen or bathroom spray composition. Preferably, the antimicrobial composition is a topical composition applied to the skin for disinfection by significantly reducing the amount of bacteria and viruses on the skin. The composition can optionally include skin-benefitting ingredients added thereto, such as emollients, vitamins and / or derivatives thereof, resorcinols, retinoic acid precursors, colorants, moisturizers or wetting agents, fragrances, sunscreens, combinations thereof, etc., as previously described herein. The skin-benefitting ingredients can be water-soluble or oil-soluble.

[0054] Thus, the antimicrobial composition is a hydroalcoholic composition having a pH of 3.0 to 8.2, and the composition is water / alcohol continuous. As used herein, viscosity is obtained as follows: using a Brookfield viscometer (using spindle 4 at 10 rpm) or using a Discovery HR-2 rheometer (using a sandblasted plate with a gap of 1000 microns and for a first viscosity V A 0.4s -1 The first shear rate S A and for the second viscosity V B 10s -1 The second shear rate S B , both at 25°C and at 20 s intervals).

[0055] It is known to use several units in the context of viscosity, but the more frequently used units are centipoise (cP), Pascal seconds (Pa*s) and milliPascal seconds (mPa*s), and these units are easily convertible to each other with the help of publicly available resources such as textbooks, encyclopedias and the Internet. In yet another embodiment, the composition is a non-therapeutic and non-pharmaceutical composition, which is a hydroalcoholic solution with a viscosity below 10,000 centipoise (cP) (10 Pa*s), preferably a viscosity below 5,000 cP (5 Pa*s), preferably a viscosity of 0.8 to 3,000 cP (0.0008 to 3 Pa*s), more preferably a viscosity of 0.8 to 2,000 cP (0.0008 to 2 Pa*s).

[0056] Typically, the viscosity of the antimicrobial composition will be less than 10,000 cP (10 Pa*s). Typically, the viscosity of the antimicrobial composition will be 0.8 to 5,000 cP (0.0008 to 5 Pa*s), preferably 0.8 to 3,000 cP (0.0008 to 3 Pa*s), more preferably 0.8 to 2,000 cP (0.0008 to 2 Pa*s), and even more preferably 0.8 to 1,000 cP (0.0008 to 1 Pa*s), including all ranges subsumed therein.

[0057] The antimicrobial composition can be prepared by any method for preparing an antimicrobial composition. In one embodiment, the method for preparing the antimicrobial composition may include the following: combining a sensory oil and a moisturizer to form a first phase. Then combining water and an alcohol to form a second phase. Then combining the first phase and the second phase to form a third phase. Adding a neutralizing agent to the third phase to form the antimicrobial composition.

[0058] Example

[0059] The following examples are merely illustrative of the antimicrobial composition disclosed herein and are not intended to limit the scope thereof.

[0060] Embodiment 1:

[0061] Samples 1 and 2 are examples demonstrating the composition of the antimicrobial composition disclosed herein.

[0062] Table 1 - All figures are shown as weight %

[0063]

[0064]

[0065] The level of alcohol present in the antimicrobial composition can be adjusted based on the percentage purity of the alcohol. For example, the ethanol purity should preferably be 92% w / w to 94% w / w, so that if 92% pure ethanol is used, the ethanol can be used in an amount of 70 to 80% by weight, such as 72% by weight.

[0066] Table 2 shows the oils that can be used in antibacterial compositions to design a transparent and fast-drying hand disinfectant spray formulation with a non-sticky feel. These examples are not meant to limit the materials that can be used, but are merely to illustrate the types and levels of oils selected based on three criteria. The oils preferably used are those with a solubility greater than 30% in at least a 75 / 25 EtOH / water blend, reflecting the good solubility in the formulation shown in Sample 1. In addition, the oil must be liquid at room temperature so that once left as a film, the composition does not impart any negative feeling. Finally, the preferred oil itself must not have a solubility for water so that during application and when drying, as ethanol and water evaporate, water is also allowed to evaporate rapidly, leaving only the oil and any skin-benefitting active substance / moisturizer (if present). Without wishing to be bound by theory, it is believed that when a hand disinfectant formulation with a preferred oil as disclosed herein is applied to the skin and as water and ethanol evaporate, if the oil has a good solubilizing ability for water, this will delay evaporation and drive towards an undesirable slower drying and stickier feel.

[0067] Table 2

[0068]

[0069] Table 2 shows examples of oils that do and do not meet three criteria, including: (1) the oil must be a liquid; (2) the oil must be soluble in at least a 75 / 25 EtOH / water mixture; and (3) the oil must have no solvent power for water and, therefore, be ideal for use in the disclosed antimicrobial compositions.

[0070] Embodiment 2:

[0071] The composition of Sample 2 was used to test moisturizing, restorative wound healing test, and melanin content.

[0072] Moisturization was measured by visual measurements (dryness and erythema) and instrumental hydration assessment with Skicon and Skin Hydration Tester.Measurements were obtained at baseline, 2 hours, 4 hours, 6 hours and 8 hours after a single controlled product application.

[0073] As can be seen from the data, the disinfectant prepared with the composition of Sample 2 showed an improvement in hydration at all time points compared to the baseline. The disinfectant prepared with the composition of Sample 2 was also superior in hydration compared to the untreated control site.

[0074] Sample 2 was tested and compared to samples 3 and 4. The formulations of samples 2 to 4 are shown in Table 3. Samples 4 and 5 were untreated skin to which no disinfecting composition was applied.

[0075] Table 3

[0076]

[0077]

[0078] Participants entered a 5-day conditioning phase, during which they were instructed to use A white soap bar was used for all general bathing and showering, including the test site (forearm). Participants were asked to avoid using any additional products on the test area during the study and to avoid scraping for two days before or during the product application and assessment phase. Participants were also instructed to bathe at least 12 hours before the study.

[0079] At the baseline visit, participants with a visual dryness score of 0 to 2.5 and an erythema score of ≤2.0 (0-6 scale) at each site on the volar forearm and a grade difference between adjacent sites of no more than ±0.5 or 1.0 units overall entered the product application phase. A total of 8 test sites (4 cm×4 cm) were randomly assigned to the participant's right or left volar forearm. Treatment sites were balanced across all sites on the volar forearm by a carry-over Latin square design.

[0080] Before the product application phase, a baseline assessment of visual assessment of dryness and erythema was obtained by an expert visual assessor and instrumental assessment of hydration (Skicon: conductance, Skin Hydration Tester: capacitance). After the baseline measurement, the investigator performed a single controlled product application. The product application procedure is described as follows:

[0081] The researcher dispensed 0.035 mL of the test product onto the test site using a repeating pipette. Using a gloved finger, the test product was thoroughly rubbed onto the designated test site in a circular motion until the site was completely wet. The site was then allowed to air dry.

[0082] Two test sites were left untreated on each subject, which formed Samples 3 and 4.

[0083] Visual assessments of dryness, dermatometrometer, and Skicon measurements were then obtained at 2, 4, 6 hours (±15 minutes), and 8 hours (±30 minutes) after application. Prior to assessment, participants acclimatized for a minimum of 20 minutes in a room maintained at 66.3°F to 70.1°F (19.0°C to 21.2°C) and 38% to 55% relative humidity. One trained assessor performed all visual assessments during the treatment phase. Each instrument used more than one trained operator to collect instrument readings.

[0084] Visual dryness analysis, such as assessing change from baseline (CFB) within a product or assessing differences in CFB for pairs of products, was done using a simple pairwise nonparametric method (Wilcoxon signed-rank test with Pratt-Lehman adjustment).

[0085] For instrumental data, within each product / untreated site, each assessment time point was compared to baseline using a two-tailed paired t-test at a 95% confidence level. Between-treatment analyses of instrumental measures applied a single linear model at each time point (with CFB as the outcome variable, BL as a covariate, and PRODUCT as the efficacy of interest), with all products compared to all others. For each product's CFB, all comparisons of interest were also performed for all product comparisons.

[0086] No visual erythema was observed during the study period for any sample or untreated site.

[0087] During the hydration assessment with the dermatothromycete, samples 2 to 4 were evaluated. As shown in Table 4, samples 3 and 4 showed no change or deterioration in dermatothromycete levels from baseline at all time points after application. Sample 2 showed improvement at all time points after one application.

[0088] Table 4: Skin hydration CFB values ​​of the CM825 skin moisture tester on the palmar forearm

[0089]

[0090]

[0091] As can be seen in Table 2, Sample 2 showed a statistically significant increase in hydration by the Skin Hydration Meter at all time points. At the 8 hour time point, Samples 3 and 4 showed a statistically significant increase in hydration by the Skin Hydration Meter. "BL" in Table 5 refers to Baseline. The baseline is the starting point of the measurement.

[0092] Table 5: Skicon 200-EX: Skin surface hydration - CFB, based on Log10 transformed values ​​at the volar forearm

[0093]

[0094] As shown in Table 5, Sample 2, the sample of the present invention, showed a significant increase in hydration by Skicon at all time points, and Samples 3 and 4 showed a slight increase in hydration at all time points.

[0095] Example 3

[0096] In this embodiment, the restorative wound healing and barrier repair of various combinations of beneficial agents were tested. For wound healing assessment, cells were grown to 80% confluence and treated with bioactive substances for 24 to 36 hours. After treatment, scratches were produced on the cells, and the closure of the wound was monitored after incubation for 24 hours. The closure of the scratch area was calculated as the closure % of the wound. Microscope images were captured at a magnification of 4x, and the open wound area was measured using software CellSens for analysis. Wound closure in percentage = (the average value of the readings of the open wound area at (t=24) - the average value of the readings of the open wound area at (t=0) / the average value of the readings at (t=0)) * 100. Table 6 lists the results of wound healing assays.

[0097] Table 6

[0098]

[0099] As can be seen in Table 6, a significant improvement in wound healing was observed with the combination of vitamin B3, vitamin E, aloe vera and sodium hyaluronate, a statistically significant improvement compared to either vitamin B3 or vitamin E alone.

[0100] Example 4

[0101] In this embodiment, melanin content determination is carried out to determine the inhibition or melanin reduction found with various combinations of beneficial active substances as shown in Table 7. In this embodiment, cells are grown for 24 hours and treated with bioactive substances and incubated for 72 hours. After treatment, cells are lysed and absorbance is measured at 405nm. Lysate is transferred to a fresh 384-well transparent flat-bottom plate, and the original diameter is measured at 405nm using a FlexStation 3 reader. (The reduction % of melanin content is measured by taking the average absorbance value of the control - the average absorbance value of the treated cells / the average absorbance value of the control) * 100).

[0102] Table 7

[0103]

[0104] In this melanin content assay, 10 micromoles of 4-hexylresorcinol produced about 33% inhibition (baseline). Any inhibition above ~15% is generally considered significant in a melanin content assay. Thus, from Table 7, it can be seen that the combination of vitamin B3, vitamin E, and aloe vera showed significant inhibition of melanin content at both vitamin E levels. In addition, the combination of vitamin B3, vitamin E, aloe vera, and sodium hyaluronate showed significant inhibition of melanin content.

[0105] In the absence of further explicit instructions, all ranges described herein are intended to include all ranges included therein.As used herein, unless explicitly described, otherwise substantially free of means less than 10 weight %.Antimicrobial benefit means at least 2 logarithmic kills in 3 minutes or even 10 seconds, preferably at least 3 logarithmic kills, wherein antimicrobial assessment is measured by ASTM International Standard Method E2783-11 (re-approved in 2016), which describes the program for measuring the antimicrobial activity of water-miscible compounds using time-killing procedures.As described in ASTM International Standard Method 1052-20, the inactivation of viruses (or viruses) is determined by assessing the impact of microbicides on viruses.The term includes and is intended to encompass the term substantially consisting of ... consisting of and consisting of ... consisting of. In order to avoid doubt, and for illustration, the composition comprising water, cationic surfactants and preservatives means including the composition substantially consisting of and consisting of.

[0106] Unless expressly stated otherwise, all numbers in this specification expressing amounts of material or reaction conditions, physical properties of materials and / or use are to be understood as modified by the word “about.” Unless otherwise stated, all amounts are by weight of the final composition.

[0107] It should be noted that when specifying any range of concentration or amount, any specific higher concentration can be associated with any specific lower concentration or amount and any sub-range contained therein. In this regard, it should be noted that all ranges disclosed herein include endpoints, and the endpoints can be combined independently of each other (e.g., "up to 25% by weight, or more specifically, 5% by weight to 20% by weight range", including 5% by weight to 25% by weight The endpoint and all intermediate values ​​of the range, etc.). "Combination" includes blends, mixtures, alloys, reaction products, etc. In addition, the terms "first", "second", etc. herein do not represent any order, quantity, or importance, but are used to distinguish one element from another element. Unless otherwise specified herein or clearly contradictory to the context, the terms "one (a)" and "an" and "the" herein do not represent the limitation of quantity, and should be interpreted as covering the singular and plural. The suffix "(s)" as used herein is intended to include both the singular and plural of the term it modifies, thereby including one or more terms (e.g., film (s) includes one or more films). References throughout the specification to "one embodiment," "one aspect," "another embodiment," "another aspect," "an embodiment," "aspect," etc. mean that a particular element (e.g., feature, structure, and / or characteristic) described in conjunction with that embodiment or aspect is included in at least one embodiment or aspect described herein, and may or may not be present in other embodiments or aspects. In addition, it should be understood that the described elements may be combined in any suitable manner in the various embodiments or aspects.

[0108] All cited patents, patent applications and other references are incorporated herein by reference in their entirety. However, if a term in this application contradicts or conflicts with a term in the incorporated reference, the term from this application takes precedence over the conflicting term from the incorporated reference. Although specific aspects have been described, alternatives, modifications, variations, improvements and substantial equivalents that may not be currently foreseeable are conceivable by the applicant or other persons skilled in the art. Therefore, the attached claims submitted and possibly modified are intended to cover all such alternatives, modifications, variations, improvements and substantial equivalents.

[0109] For the avoidance of doubt, the word "comprising" is intended to mean "including" but not necessarily "consisting of" or "composed of." In other words, the listed steps, options or alternatives need not be exhaustive.

[0110] The disclosure of the present invention as found herein is considered to cover all aspects as found in claims that are multiple dependent on each other, regardless of the fact that the claims can be found without multiple dependence or redundancy. Unless otherwise stated, numerical ranges expressed in the form of "x to y" should be understood to include x and y. When specifying the value or amount of any range, any specific upper limit value or amount can be associated with any specific lower limit value or amount. Unless otherwise stated, all percentages and ratios contained herein are calculated by weight. The various features of the present invention mentioned in the above sections are appropriately applicable to other parts with necessary changes. Therefore, the features specified in one section can be appropriately combined with the features specified in other sections. Adding any section headings is only for convenience and is not intended to limit the present disclosure in any way.

Claims

1. A transparent antibacterial composition comprising: water; alcohol; Moisturizers; and sensory oil; wherein the sensory oil must be liquid at room temperature, the sensory oil must be soluble in at least 75 / 25 EtOH / water, and the sensory oil must have no solubility in water; and the water is present in an amount of 8 to 30 wt%, and the alcohol is present in an amount of 62 to 75 wt%; wherein the humectant is present in an amount of 3 to 10 wt%; the antibacterial composition does not contain an additional antibacterial agent.

2. The antimicrobial composition according to claim 1, wherein the organoleptic oil is present in an amount of 0.01 to 10% by weight.

3. The antimicrobial composition according to any one of the preceding claims, wherein the sensory oil comprises dicarboxylic acid esters, lactic acid esters, triglycerides, soybean oil, fatty acid esters, (poly)propylene glycol fatty ethers or combinations thereof, wherein the addition of the sensory oil does not affect the transparency of the antimicrobial composition.

4. The antimicrobial composition of claim 3, wherein the sensory oil comprises a sensory oil soluble in at least 75 / 25 EtOH / water selected from diisopropyl adipate, diisopropyl sebacate or diethylhexyl malate, lauryl lactate, myristyl lactate, cetyl lactate, isostearyl alcohol, PPG15 stearyl ether or a combination thereof. The antimicrobial composition according to claim 1 , wherein the alcohol comprises ethanol, isopropanol, n-propanol or a combination thereof. The antimicrobial composition according to claim 1 , wherein the humectant is present in an amount of 3 to 7 wt %.

7. The antibacterial composition according to claim 1, wherein the humectant comprises glycerin, butylene glycol, propylene glycol, polyethylene glycol, sorbitol, polyglycerol, isopentyl glycol, hyaluronic acid or a combination thereof.

8. The antimicrobial composition of claim 1, further comprising a skin benefit agent.

9. The antimicrobial composition of claim 8, wherein the skin benefit agent comprises niacinamide, tocopherol, aloe vera, sodium or potassium hyaluronate, alpha-hydroxy acids and esters, beta-hydroxy acids and esters, hydroxyethyl urea, polyhydroxy acids and esters, creatine, hydroquinone, t-butyl hydroquinone, mulberry extract, licorice extract, or a combination thereof.

10. The antimicrobial composition according to claim 1, wherein the antimicrobial composition is in liquid form. The antimicrobial composition according to claim 1 , further comprising a chelating agent.

12. The antimicrobial composition according to claim 1, wherein the water is present in an amount of 10 to 25 wt%.

13. The antimicrobial composition according to claim 1, wherein the water is present in an amount of 10 to 20 wt%.

14. The antimicrobial composition of claim 1, wherein the alcohol is present in an amount of 65 to 75 wt%.

15. The antimicrobial composition of claim 2, wherein the organoleptic oil is present in an amount of 0.5 to 5 wt%.

16. The antimicrobial composition according to claim 10, wherein the antimicrobial composition is in the form of a liquid spray antimicrobial composition.

17. The antimicrobial composition of claim 11, wherein the chelating agent comprises ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), pentasodium diethylenetriaminepentaacetate, trisodium N-(hydroxyethyl)-ethylenediaminetriacetate, sodium thiocyanate, trisodium methylglycine diacetate, tetrasodium glutamate diacetate, and phytic acid.

18. The antimicrobial composition of claim 11, wherein the chelating agent is ethylenediaminetetraacetic acid (EDTA), diethylenetriaminepentaacetic acid (DTPA), ethylenediaminedisuccinic acid (EDDS), or a combination thereof.

19. A method for preparing a transparent antibacterial composition, comprising: Combine sensory oils and moisturizers to form a first phase; combining water and alcohol to form a second phase; combining the first phase and the second phase to form a third phase; and adding a neutralizing agent to the third phase to form the antimicrobial composition, wherein the sensory oil must be liquid at room temperature, the sensory oil must be soluble in at least 75 / 25 EtOH / water, and the sensory oil must have no solubility in water; and the water is present in an amount of 8 to 30 wt%, and wherein the alcohol is present in an amount of 62 to 75 wt%; wherein the humectant is present in an amount of 3 to 10 wt%; and the antibacterial composition does not contain an additional antibacterial agent.

20. The method of claim 19, further comprising adding a fragrance to the antimicrobial composition.

21. The method of claim 19, wherein the water is present in an amount of 10 to 25 wt%.

22. The method of claim 19, wherein the water is present in an amount of 10 to 20 wt%.

23. The method of claim 19, wherein the alcohol is present in an amount of 65 to 75 weight percent.

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