An endoscope visualization assisted mouse gavage device

Abstract

The application discloses an endoscope developing auxiliary mouse gavage device, which comprises a connecting frame, an endoscope and a gavage device.The connecting frame comprises a fixing ring and a clasp, and the fixing ring and the clasp are arranged in the same direction, and a supporting spring is fixedly connected between the fixing ring and the clasp; the endoscope is installed in the fixing ring; and the gavage device is detachably connected in the clasp, and the gavage device is correspondingly arranged with the endoscope.The application effectively solves the shortcomings that the gavage operation of the mouse has a high threshold and is easy to cause the death of the mouse, greatly reduces the loss of the mouse caused by the gavage, takes into account the convenience, improves the success rate of the gavage operation, and improves the accuracy of gavage experimental data.

Description

Technical Field

[0001] This invention belongs to the field of biomedicine, and in particular relates to an endoscopic imaging-assisted gavage device for mice. Background Technology

[0002] Gavage administration to mice is a routine procedure for toxicological testing in the field of biomedical experiments. It generally involves using a gavage device to inject the drug solution directly into the animal's stomach through its mouth. The procedure is simple, allows for precise drug administration, flexible control of the dosage, and can effectively simulate the series of in vivo effects of drugs after oral administration in clinical settings.

[0003] The drawbacks of existing gavage devices are that they are limited by the size of the animal and the operating site. When gavage mice, the blind insertion method of the gavage needle makes it impossible to accurately locate the entrance of the esophagus, and the needle is very likely to be inserted into the trachea, causing the mouse to die. At present, many experimental animals are high-value transgenic mice, which are very expensive, and the death of any one of them may lead to significant economic losses. In addition, existing gavage devices are prone to damaging the mouse esophagus, and the gavage operation is difficult to control precisely, which can easily cause drug loss and affect the experimental results.

[0004] Therefore, there is an urgent need for an endoscopic imaging-assisted gavage device for mice to solve the above-mentioned technical problems. Summary of the Invention

[0005] To address the aforementioned technical problems, this invention proposes an endoscopic imaging-assisted gavage device for mice.

[0006] To achieve the above objectives, the present invention provides an endoscopic imaging-assisted mouse gavage device, comprising:

[0007] A connecting frame, comprising a fixing ring and a retaining ring, wherein the fixing ring and the retaining ring are arranged in the same direction, and a support spring is fixedly connected between the fixing ring and the retaining ring;

[0008] An endoscope, wherein the endoscope is mounted within the retaining ring;

[0009] A gavage device is detachably connected to the retaining ring, and the gavage device is configured correspondingly to the endoscope.

[0010] Preferably, the retaining ring has a notch on the side away from the supporting spring, and the width of the notch is smaller than the width of the endotracheal device.

[0011] Preferably, the gavage device includes a gavage needle, one end of which is fixedly connected to a smooth ball head, and the other end of which is fixedly connected to and communicates with a connector for connecting a syringe. The connector is detachably connected to the retaining ring, and the outer diameter of the connector is smaller than the width of the notch.

[0012] Preferably, the endoscope includes a camera tube installed within the fixing ring, the camera tube being configured corresponding to the gavage device; a camera is installed at the end of the camera tube corresponding to the ball head.

[0013] Preferably, the diameter of the camera is 3mm-5mm, and the inner diameter of the camera tube is adapted to the outer diameter of the camera.

[0014] Compared with existing technologies, this invention has the following advantages and technical effects: The connecting frame in this invention fixes the gavage device and endoscope together, allowing for visual guidance of the gavage operation via the endoscope, thus enabling precise insertion into the mouse stomach. This lowers the technical barrier to mouse gavage, making the experiment easier and avoiding errors such as insertion into the trachea causing esophageal damage or even death, significantly improving the success rate of gavage. The retaining ring is detachably connected to the gavage device, allowing the use of different models of gavage devices according to gavage needs, providing good adaptability and flexible adjustment. The support spring has a small deformation range, primarily serving to buffer the compression caused by gavage devices of various sizes, improving the overall stability of the device. This invention effectively solves the shortcomings of high operational barriers and high mortality rates associated with mouse gavage, greatly reducing mouse losses due to gavage, while also ensuring convenience, improving the success rate of gavage operations, and enhancing the accuracy of gavage experimental data. Attached Figure Description

[0015] The accompanying drawings, which form part of this application, are used to provide a further understanding of this application. The illustrative embodiments and descriptions of this application are used to explain this application and do not constitute an undue limitation of this application. In the drawings:

[0016] Fig. 1 This is an axial view of the endoscopic imaging-assisted mouse gavage device of the present invention;

[0017] Fig. 2 This is a front view of the endoscopic imaging-assisted mouse gavage device of the present invention;

[0018] Fig. 3 This is an axial view of the connecting frame of the present invention;

[0019] Fig. 4 This is a fixed ring axis view of Embodiment 2 of the present invention;

[0020] Fig. 5 This is a side view of the fixed ring structure according to Embodiment 2 of the present invention;

[0021] Fig. 6 This is a schematic diagram of the main view of the fixed ring structure in Embodiment 2 of the present invention.

[0022] In the diagram: 1. Connecting frame; 2. Endoscope; 3. Gavage device; 11. Fixing ring; 12. Snap ring; 13. Support spring; 14. Notch; 15. Extension tube; 16. Limiting groove; 17. Guide groove; 18. Limiting rod; 19. Slide tube; 110. Adjusting tube; 111. Clamping head; 112. Flexible sleeve; 113. Positioning ring; 21. Camera tube; 22. Camera; 31. Gavage needle; 32. Ball head; 33. Connector; 34. Syringe. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0025] Example 1

[0026] Reference Figs. 1-3 As shown, this embodiment provides an endoscopic imaging-assisted mouse gavage device, comprising:

[0027] Connecting frame 1, the connecting frame 1 includes a fixing ring 11 and a retaining ring 12, the fixing ring 11 and the retaining ring 12 are arranged in the same direction, and a support spring 13 is fixedly connected between the fixing ring 11 and the retaining ring 12;

[0028] Endoscope 2 is installed inside the retaining ring 11;

[0029] The gavage device 3 is detachably connected to the retaining ring 12, and the gavage device 3 is set in correspondence with the endoscope 2.

[0030] In this invention, the connecting frame 1 fixes the gavage device 3 and the endoscope 2 together, allowing for visual guidance of the gavage operation through the endoscope 2, thus enabling precise insertion into the mouse stomach. This lowers the technical threshold for mouse gavage, making the experiment easier and avoiding errors such as insertion into the trachea causing esophageal damage or even death, significantly improving the success rate of the gavage operation. The retaining ring 12 is detachably connected to the gavage device 3, allowing for the use of different models of gavage devices 3 according to gavage needs, providing good adaptability and flexible adjustment. The support spring 13 has a small deformation range, and its main function is to buffer the compression caused by gavage devices 3 of various sizes, improving the overall stability of the device.

[0031] To further optimize the design, a notch 14 is provided on the side of the retaining ring 12 away from the supporting spring 13. The width of the notch 14 is smaller than the width of the gavage device 3. The notch 14 is mainly designed to create an open structure for the retaining ring 12. Combined with the elasticity of the material itself, the retaining ring 12 has good adaptability to various models of gavage devices 3. When using it, it is inserted from one end until the gavage device 3 is locked in place; when replacing it, it is pulled out in the opposite direction.

[0032] Further optimization of the design: the gavage device 3 includes a gavage needle 31, one end of which is fixedly connected to a smooth ball head 32, and the other end of which is fixedly connected to and connected to a connector 33 for connecting a syringe 34. The connector 33 is detachably connected to the retaining ring 12, and the outer diameter of the connector 33 is smaller than the width of the notch 14. The gavage needle 31 is made of medical-grade stainless steel and can be either a straight needle or a curved needle, depending on the requirements. The specific selection method is existing technology and will not be elaborated here. The ball head 32 is fixed to one end and has a smooth surface. It is used to insert into the esophagus and stomach of the mouse to prevent sharp tips from piercing the esophagus and stomach of the mouse, thereby reducing the harm caused by gavage to the mouse and thus reducing the loss of experimental mice. The connector 33 is snapped into the retaining ring 12. Its inlet is of standard specification and is used for detachable connection with the syringe 34 containing the drug. Different models of syringe 34 can be selected according to requirements. In this embodiment, the syringe 34 is a common medical type with graduations on the surface to control the amount of drug administered by gavage.

[0033] Further optimizing the design, the endoscope 2 includes a camera tube 21 installed within a fixing ring 11, which corresponds to the gavage needle 31. A camera 22 is installed at the end of the camera tube 21 corresponding to the ball head 32. The camera tube 21 passes through the inner wall of the retaining ring 12 and is fixed in place. A miniature camera 22 is installed at the tip of the camera tube 21 corresponding to the ball head 32 to capture the surrounding ring. During use, it is inserted into the mouse's body together with the ball head 32 of the gavage needle 31, enabling visualization of the gavage process. This facilitates accurate confirmation of the mouse's esophagus and the depth of the gavage, preventing injury to the mouse caused by blind insertion of the gavage needle 31. The signal from the camera 22 (generally a wired connection, with the signal line located inside the camera tube 21, not shown in the figure, but a wireless connection can also be used) is exported through the camera tube 21 and displayed on a display device (a regular display screen or a mobile phone screen, not shown in the figure), allowing the operator to observe and accurately locate the mouse's esophagus and control the insertion direction.

[0034] Furthermore, the bending of the camera tube 21 can be controlled externally, making it convenient to control the forward direction of the camera 22 and find the accurate location of the mouse esophagus.

[0035] Further optimization of the design involves using a camera 22 with a diameter of 3mm-5mm, and ensuring that the inner diameter of the camera tube 21 matches the outer diameter of the camera 22. A thinner inner diameter of the camera tube 21 is chosen to accommodate the small-diameter camera 22, reducing space occupation and minimizing impact on the gavage process. In this embodiment, the preferred lens diameter for the camera 22 is 3.9mm. For details, please refer to the 3.9mm endoscopic high-definition camera automotive industrial pipe USB miniature probe, which allows for easy connection to a computer or mobile phone.

[0036] Example 2

[0037] See attached document Figs. 4-6 As shown, the difference between this embodiment and embodiment 1 is that the fixing ring 11 in this embodiment is provided with a locking component, which can be adapted to camera tubes 21 of different specifications, and the installation is tighter and more stable, and it is more convenient to disassemble.

[0038] The locking assembly includes an extension cylinder 15 fixedly connected to the end of the fixing ring 11 away from the camera 22. The extension cylinder 15 has a plurality of limiting grooves 16 opened in the direction of the fixing ring 11, and the plurality of limiting grooves 16 are evenly distributed in the circumferential direction. The fixing ring 11 has a guide groove 17 adapted to the limiting grooves 16, and the depth of the guide groove 17 gradually decreases in the direction away from the limiting grooves 16. A limiting rod 18 is slidably connected in the limiting groove 16, and the limiting rod 18 extends into the guide groove 17 and is slidably connected to the guide groove 17. The plurality of limiting rods 18 are fixedly connected to a sliding cylinder 19 slidably connected to the extension cylinder 15. The sliding cylinder 19 is rotatably connected to an adjusting cylinder 110, and the adjusting cylinder 110 is threadedly connected to the extension cylinder 15. When clamping, rotating the adjusting cylinder 110 causes the sliding cylinder 19 to slide, which in turn pushes the limiting rod 18 into the guide groove 17. As the depth of the guide groove 17 gradually decreases, the limiting rod 18 deforms, increasing the height of the limiting rod 18 protruding towards the inner cavity of the fixing ring 11. Finally, the ends of several limiting rods 18 clamp the camera tube 21, locking the camera tube 21 and preventing slippage between it and the camera tube 21 during the advancement process, thus reducing the deviation of the gavage needle 31. When replacement is needed, rotating the adjusting cylinder 110 in the opposite direction causes the limiting rod 18 to retract, releasing the camera tube 21 for easy replacement. This embodiment allows for the selection and fixing of camera tubes 21 of any diameter within the adjustment range, improving the adaptability of the camera tube 21 and the stability of the fixing of the camera tube 21, making the device more practical and easier to use.

[0039] Furthermore, a protruding locking head 111 is fixed to the side of the limiting rod 18 that is away from the extension tube 15 and contacts the camera tube 21, increasing the gripping force of the limiting rod 18 on the camera tube 21.

[0040] Furthermore, a flexible sleeve 112 is embedded inside the fixing cylinder, through which the camera tube 21 passes. The limiting rod 18 is located outside the flexible sleeve 112 and contacts its outer wall. The clamping head 111 faces and abuts against the outer wall of the flexible sleeve 112. The flexible sleeve 112 and the camera tube 21 are interference-fitted to prevent the hard fixing ring 11 from scratching the camera tube 21, thus extending its service life. At the same time, it prevents the camera tube 21 from sliding freely, improving the stability of fixing the camera tube 21. When the limiting rod 18 clamps, the clamping head 111 causes the corresponding position of the flexible sleeve 112 to protrude inward, increasing the gripping force on the camera tube 21. Combined with the fixing property of the interference fit between the flexible sleeve 112 and the camera tube 21, the camera tube 21 is more stable, improving the success rate of gastric enema.

[0041] Furthermore, a positioning ring 113 is fixed to the end of the extension cylinder 15 to prevent the adjusting cylinder 110 from disengaging from the extension cylinder 15.

[0042] In the description of this invention, it should be understood that the terms "longitudinal", "lateral", "up", "down", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this invention, and are not intended to indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of this invention.

[0043] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. An endoscopic imaging-assisted mouse gavage device, characterized in that, include: A connecting frame (1) includes a fixing ring (11) and a retaining ring (12). The fixing ring (11) and the retaining ring (12) are arranged in the same direction, and a support spring (13) is fixed between the fixing ring (11) and the retaining ring (12). Endoscope (2), the endoscope (2) is installed inside the fixing ring (11); A gavage device (3) is detachably connected to the retaining ring (12), and the gavage device (3) is correspondingly set with the endoscope (2); The gavage device (3) includes a gavage needle (31), one end of which is fixed with a smooth ball head (32). The endoscope (2) includes a camera tube (21) installed in the fixing ring (11), and the camera tube (21) is correspondingly arranged with the gavage needle (31); a camera (22) is installed at the end of the camera tube (21) corresponding to the ball head (32). The fixing ring (11) is provided with a locking component, which can be adapted to the camera tube (21) of different specifications. The locking assembly includes an extension cylinder (15) fixedly connected to one end of the fixed ring (11) away from the camera (22). The extension cylinder (15) has a plurality of limiting grooves (16) opening towards the fixed ring (11), and the plurality of limiting grooves (16) are evenly distributed circumferentially. The fixed ring (11) has a guide groove (17) adapted to the limiting grooves (16), and the depth of the guide groove (17) gradually decreases in the direction away from the limiting grooves (16). A limiting rod (18) is slidably connected in the limiting groove (16), and the limiting rod (18) extends into the guide groove (17) and is slidably connected to the guide groove (17). The plurality of limiting rods (18) are fixedly connected to a sliding cylinder (19) slidably connected to the extension cylinder (15). The sliding cylinder (19) is rotatably connected to an adjusting cylinder (110), and the adjusting cylinder (110) is threadedly connected to the extension cylinder (15). The side of the limiting rod (18) that is away from the extension tube (15) and contacts the camera tube (21) has a protruding clamp (111) fixed to it, which increases the grip of the limiting rod (18) on the camera tube (21).

2. The endoscopic imaging-assisted mouse gavage device according to claim 1, characterized in that: The retaining ring (12) has a notch (14) on the side away from the support spring (13), and the width of the notch (14) is smaller than the width of the endotracheal tube (3).

3. The endoscopic imaging-assisted mouse gavage device according to claim 2, characterized in that: The other end of the gavage needle (31) is fixed and connected to a connector (33) for connecting a syringe (34). The connector (33) is detachably connected to the retaining ring (12). The outer diameter of the connector (33) is smaller than the width of the notch (14).

4. The endoscopic imaging-assisted mouse gavage device according to claim 1, characterized in that: The diameter of the camera (22) is 3mm-5mm, and the inner diameter of the camera tube (21) is adapted to the outer diameter of the camera (22).

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