Anorectal drug delivery device with micro-opening medicine outlet

Abstract

A drug outlet micro-opening anorectal drug delivery device comprises a main body which is a hollow rod-shaped component and an auxiliary component, the internal space of the main body of the rod-shaped component constituting a drug channel for delivering drugs, the drug channel being provided with at least one drug inlet located at the bottom end of the tail of the rod-shaped component and at least one first drug outlet located at the head; the main body of the auxiliary component is in the shape of a hollow cap, which is at least sleeved on the head of the rod-shaped component, and the auxiliary component is provided with at least one second drug outlet communicating with the internal space of the auxiliary component; it also comprises a sealing body which is partially embedded in or completely covered in the internal space of the auxiliary component, the sealing part of the sealing body enters the drug channel through the first drug outlet, thereby closing the first drug outlet to the outside; when in use, the sealing part is driven to displace axially, thereby disengaging from the sealing position, the first drug outlet is opened, and the liquid or paste-like medicine entering the drug channel flows out first through the first drug outlet and then through the second drug outlet provided on the auxiliary component.

Description

Technical Field

[0001] The present invention relates to an anorectal drug delivery device with a micro-motion opening of a drug outlet, belonging to the technical field of medical devices. Background Art

[0002] The anal sinus at the end of the human rectum, located on the dentate line, is also called the anal crypt. It is funnel-shaped and opens upward, usually with 6 to 8 of them. There are anal glands inside the anal sinus. The secretions of the anal glands can lubricate defecation. During defecation, the depression of the anal sinus becomes shallower and the inner wall of the anal sinus comes into contact with feces. When the anal gland opening is blocked by feces, the lubricating fluid secreted by the anal gland cannot enter the anal sinus. The inside of the anal sinus becomes dry, and the depression becomes shallower. The inner wall of the anal sinus without lubrication comes into contact with feces, which increases the friction between the feces and the anal canal wall and affects the smooth discharge of feces. In addition, the anatomical characteristics of the anal sinus make it easy for feces and foreign matter to accumulate therein. Once infected by bacteria, its inflammatory substances are difficult to drain smoothly. Inflammation of the anal sinus often stimulates the anal sphincter, causing spasms and constipation, and can also lead to other anorectal diseases such as perianal abscesses.

[0003] Constipation is a common clinical symptom, with a prevalence of up to 27% in the population. Among current clinical solutions for constipation, rectal medication is the most widely used treatment. For example, one principle of rectal medication for constipation is to inject a medication into the rectum to lubricate the anorectal wall, soften it, and expel feces, thereby alleviating constipation symptoms. The most typical rectal medication device is a suppository. Before using a suppository, a plug or cap is usually used to block the discharge port to prevent leakage. During use, the plug or cap is removed and the rigid injection rod is pushed into the anus. This mechanical damage to the anorectal mucosa is susceptible, making the procedure relatively cumbersome.

[0004] The present invention provides an anorectal drug delivery device with a micro-opening medicine outlet, which contacts the anorectal mucosa with a flexible auxiliary component. Before use, the sealing body can be pressed with external force to drive the sealing part of the sealing body out of the sealing position. The operation is simple. The liquid outlet is located on the side, so the medicine can more easily contact the anorectal wall to lubricate defecation and provide sufficient and accurate medicine delivery. Summary of the Invention

[0005] The object of the present invention is achieved like this:

[0006] A drug outlet micro-opening anorectal drug delivery device, comprising a hollow rod-shaped component and an auxiliary component, the rod-shaped component body is divided into a rod-shaped component tail, a rod-shaped component middle part, and a rod-shaped component head, the internal space of the rod-shaped component body constitutes a drug channel for delivering drugs, the drug channel is provided with at least one drug inlet located at the bottom end of the rod-shaped component tail and at least one first drug outlet located at the head; the auxiliary component body is in the shape of a hollow cap, and is divided into an auxiliary component tail, an auxiliary component middle part, and an auxiliary component head, the auxiliary component is at least sleeved on the rod-shaped component head, that is, the rod-shaped component head is covered in the internal space of the auxiliary component, and the auxiliary component is provided with at least one The second drug outlet, the auxiliary component has a material hardness lower than that of the rod-shaped component, and also includes a sealing body that is partially embedded in or completely covered in the internal space of the auxiliary component. The sealing body is divided into a force-bearing part, a connecting part, and a sealing part. The sealing part of the sealing body enters the drug channel through the first drug outlet, thereby closing the first drug outlet to the outside; when in use, an external force directly or indirectly acts on the force-bearing part of the sealing body, so that it drives the sealing part to axially displace and thus break away from the sealing position, the first drug outlet is opened, and the liquid or paste-like medicine entering the drug channel first flows out through the first drug outlet and then through the second drug outlet opened on the auxiliary component; the first drug outlet and the second drug outlet are preferably designed to be adjacent to each other but partially dislocated to avoid backflow of the drug liquid.

[0007] The head of the rod-shaped component is covered in the internal space of the auxiliary component. It can be a tight and seamless covering, or a covering with a covering gap, and the covering gap is connected to the second medicine outlet; it can also be an incomplete covering with a partial hollowing out, but when in use, the soft auxiliary component is still the main contact with the anorectal mucosa.

[0008] The displacement of the sealing portion from the sealing position may be an axial displacement toward the tail of the rod-shaped component under the action of pressure, and the liquid or paste-like medicine in the medicine channel first enters the gap between the outer surface of the connecting portion of the sealing body and the inner surface of the rod-shaped component, and then enters the internal space of the auxiliary component through the first medicine outlet, and then flows out from the second medicine outlet. The displacement of the sealing portion from the sealing position may also be an axial displacement away from the tail of the rod-shaped component under the action of tension; the length of the head of the rod-shaped component may also be set as required to account for more than 50% of the length of the entire rod-shaped component, for example, in order to meet the output of medicine that the first medicine outlet is positioned closer to the medicine inlet at the bottom end of the tail of the rod-shaped component.

[0009] Furthermore, in order to enhance the stimulation of the anorectal mucosa and dilate the anal canal, the outer surface of the rod-shaped component and / or the outer surface of the auxiliary component may protrude radially outward to form at least one enlarged portion, especially at the position of each head.

[0010] In order to smoothly pass through the right angle of the human anus during insertion and to contact a larger area of ​​anorectal mucosal tissue when rotating after insertion, at least a portion of the head of the rod-shaped component and / or at least a portion of the head of the auxiliary component are bent to one side. If both are bent, they are bent to the same side.

[0011] In a specific solution, the force-bearing portion of the sealing body protrudes through the opening at the top of the auxiliary component head. When in use, the force-bearing portion of the sealing body is directly pressed to cause it to displace axially, driving the sealing portion out of the sealing position and opening the first medicine outlet.

[0012] In another specific solution, the force-bearing portion of the sealing body is embedded in the head of the auxiliary component. When in use, external force acts on the force-bearing portion of the sealing body through the head of the auxiliary component to cause it to displace axially, drive the sealing portion out of the sealing position, and open the first medicine outlet.

[0013] Furthermore, an annular rib is provided on the outer surface of the rod-shaped component to prevent the auxiliary component mounted thereon from detaching under the action of external force, specifically to prevent the auxiliary component from detaching radially from the head of the rod-shaped component.

[0014] The auxiliary component is filled with protrusions including strip-shaped, nail-shaped, boss-shaped, hook-shaped, teardrop-shaped, horizontal stripe-shaped, scattered point-shaped, serrated, beaded, wrinkled, terraced, burr-shaped, and continuous spiral-shaped protrusions and or pits that can accommodate medicine and feces.

[0015] Furthermore, at least a part of the auxiliary component is free to become a foldable part including a skirt shape, an umbrella shape, a leaf shape, and a bud shape; at least a part of the auxiliary component is free, which means that this part is not connected to the auxiliary component as a whole and can be deformed and moved within a certain range, and this deformation includes tensile deformation, bending deformation, folding deformation, etc.

[0016] Furthermore, one or more of the force-bearing part, the connecting part, and the sealing part of the sealing body are provided with fixing ribs that can be in close contact with the rod-shaped part at the first drug outlet. After the fixing ribs are in close contact with the rod-shaped part, the displacement of the sealing body is constrained, and the resetting of the sealing part of the sealing body that has been out of the sealing position due to the pressure of the drug delivery is avoided without hindering the outflow of the drug.

[0017] An optimized solution, wherein the auxiliary component is provided with a portion that is easily deformed, so that when an external force acts on the force-bearing part of the sealing body, it is easy to drive the sealing part to axially displace, so that the sealing part can easily leave the sealing position and the first drug outlet is opened; the portion that is easily deformed can be a relatively thin wall of a local section of the height of the circumference or a local circumferential bellows structure.

[0018] The anal canal is the end of the digestive tract, extending from the dentate line to the anal margin. Its length is extremely important for defecation function. In order to measure the length of the anal canal, the outer surface of the rod-shaped component is provided with scale lines with increasing values ​​from the head of the rod-shaped component to the tail of the auxiliary component, which are used to measure the length of the anal canal.

[0019] In order to firmly fix the auxiliary component and the rod-shaped component, a restraining component is also included, which is sleeved on the outer surface of the tail of the auxiliary component so that it is in close contact with the area corresponding to the rod-shaped component.

[0020] In order to transport fluid substances that can be used for lubrication, cleaning, and treatment, it also includes a container that can be sealably connected to the tail of the rod-shaped component or integrally formed, and the inner cavity of the container contains liquid or paste-like medicines; the medicines can refer to drug solutions, emulsions, ointments and gels, etc., which have the effects of lubrication, antibacterial, cleaning, promoting wound healing, etc., and can also be used for the injection of probiotics.

[0021] The beneficial effects of the present invention are:

[0022] 1. To open the medicine outlet, you only need to press or pull the seal, which is easy to operate.

[0023] 2. The first drug outlet and the second drug outlet are respectively arranged on different components. When the sealing body is displaced, the positions of the first drug outlet and the second drug outlet can be misaligned. The liquid or paste-like medicine flows out of the second drug outlet at a lower flow rate, which can fully lubricate the anorectal mucosa; and the drug outlet is arranged on the side, which can more fully lubricate the anorectal mucosa, promote defecation, and fully coat the mucosa with antibacterial and anti-edema agents.

[0024] 3. The functional structure on the flexible auxiliary component can fully wipe the anal mucosa and safely act on the defecation receptors, which is helpful for defecation induction, anal canal maintenance, and prevention and treatment of anal canal diseases such as anal sinusitis. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The accompanying drawings which do not limit the present invention are as follows:

[0026] Figure 1A : Schematic diagram of the anatomy of the anal canal and anal sinus;

[0027] Figure 1B : Schematic diagram of the cross section of the anal sinus;

[0028] Figure 1C : Schematic diagram of embodiment 1 of the present invention

[0029] Figure 1D : Cross-sectional view of embodiment 1 in the unpressed state

[0030] Figure 1E : Cross-sectional view of embodiment 1 in the unpressed state

[0031] Figure 1F: Cross-sectional view of the pressed state of Example 1

[0032] Figure 1G : Cross-sectional view of the pressed state of Example 1

[0033] Figure 1H : Schematic diagram of embodiment 1 not entering the anal canal

[0034] Figure 1I : Schematic diagram of embodiment 1 entering the anal canal

[0035] Figure 1J : Schematic diagram of withdrawing the anal canal in Example 1

[0036] Figure 2A : Schematic diagram of Example 2

[0037] Figure 2B : Cross-sectional view of embodiment 2 in the unpressed state

[0038] Figure 2C : Cross-sectional view of embodiment 2 in the unpressed state

[0039] Figure 2D : Cross-sectional view of the pressed state of Example 2

[0040] Figure 3A : Schematic diagram of embodiment 3 not folded

[0041] Figure 3B : Schematic diagram after folding of embodiment 3

[0042] Figure 4A : Cross-sectional view of embodiment 4 in the unpressed state

[0043] Figure 4B : Cross-sectional view of the pressed state of Example 4

[0044] Figure 5 : Schematic cross-section of Example 5 DETAILED DESCRIPTION

[0045] Example 1:

[0046] like Figure 1A 、 1B As shown, the position and brief structure of the human anal sinus are first described, including the anal canal A1, the dentate line A2, the anal sinus A3, and the opening A5 of the anal gland A4 being blocked by feces or foreign matter B.

[0047] like Figures 1C-1JAs shown in the series of drawings, a micro-opening anorectal drug delivery device with a drug outlet includes a hollow rod-shaped component 1 and an auxiliary component 2. The rod-shaped component 1 is divided into a rod-shaped component tail 11, a rod-shaped component middle portion 12, and a rod-shaped component head 13. The internal space of the rod-shaped component body constitutes a drug channel 10 for delivering drugs. The drug channel 10 is provided with at least one drug inlet 101 located at the bottom end of the rod-shaped component tail 11 and at least one first drug outlet 102 located at the head 13. Figure 1D 、 1E The first medicine outlet 102 is shown to be in a closed state; the auxiliary component 2 is in the shape of a hollow cap and can be made of a medical-grade thermoplastic elastomer TPE material or a silicone rubber material. It not only has good biocompatibility but also has a soft texture and is more comfortable to contact with the human body. The auxiliary component 2 is divided into an auxiliary component tail 21, an auxiliary component middle part 22, and an auxiliary component head 23. The auxiliary component 2 is at least sleeved on the rod-shaped component head 13, that is, the rod-shaped component head 13 is covered in the auxiliary component internal space 20. The auxiliary component 2 is provided with at least one auxiliary component. The auxiliary component 2 has a second drug outlet 202 connected to the internal space 20 of the rod-shaped component. The hardness of the auxiliary component 2 is lower than that of the rod-shaped component 1. The auxiliary component 2 also includes a sealing body 3 coated in the internal space 20 of the auxiliary component. The sealing body 3 is divided into a force-bearing part 31, a connecting part 32, and a sealing part 33. The sealing part 33 of the sealing body 3 enters the drug channel 10 through the first drug outlet 102, thereby closing the first drug outlet 102 to the outside. When in use, an external force directly or indirectly acts on the force-bearing part 31 of the sealing body 3, driving the sealing part 33 to axially displace and thus break away from the sealing position, and the first drug outlet 102 is opened. Figure 1F 、 1G As shown, the liquid or paste medicine F in the medicine channel 10 first passes through the annular gap 320 between the medicine channel 10 and the relatively small sealing body connecting part 32, then enters the internal space 20 of the auxiliary component through the first medicine outlet 102, and finally flows out through the second medicine outlet 202 opened on the auxiliary component 2. The relatively small refers to the comparison with the sealing part 33 of the sealing body. In this example, the sealing part 33 of the sealing body is cylindrical and is partially interference-sealed with the cylindrical medicine channel 10. When it is separated from the local medicine channel 10, the sealing part 33 of the sealing body enters the area with a larger inner diameter of the medicine channel 10, thereby releasing the closure of the medicine channel 10. The open first medicine outlet 102 has an annular gap as a whole because its central part is embedded in the middle part 32 of the sealing body; in this embodiment, the force-bearing part 31 of the sealing body 3 is significantly protruded through the top opening 230 of the auxiliary component head 23. When in use, the force-bearing part 31 of the sealing body 3 is directly pressed to cause it to displace axially, driving the sealing part 33 to disengage from the sealing position, so that the first medicine outlet 102 is opened.

[0048] like Figure 1CAs shown, the auxiliary component 2 is provided with a hook-shaped protrusion 242 and a recess 243 for accommodating medicine and feces. The outer surface 14 of the rod-shaped component is provided with scale lines S with increasing values ​​from the head 13 of the rod-shaped component to the tail 11 of the rod-shaped component, which are used to measure the length of the anal canal A1. In order to enhance the degree of stimulation to the anorectal mucosa and dilate the anal canal, the outer surface 24 of the auxiliary component protrudes outward to form at least one bulge 241. It also includes a container V that can be sealably connected to the tail 11 of the rod-shaped component, and the inner cavity V0 of the container contains a liquid or paste-like medicine F ( Figure 1E shown).

[0049] like Figures 1D-1G The outer surface 14 of the rod-shaped component is provided with an annular rib 141, which is used to prevent the auxiliary component 2 mounted thereon from detaching under the action of external force; the head 13 of the rod-shaped component is covered in the internal space 20 of the auxiliary component, which can be a tight and seamless covering, or a covering with a covering gap 201, and the covering gap 201 is connected to the second medicine outlet 202 (not shown in the figure); it can also be an incomplete covering with a partial hollowing out, but when in use, the soft auxiliary component 2 is still the main contact with the anorectal mucosa.

[0050] like Figure 1F 、 1G As shown, the sealing portion 33 is pressed to axially displace toward the tail portion 11 of the rod-shaped component and leave the sealing position. The liquid or paste-like medicine F in the medicine channel 10 first enters the gap 320 between the outer surface of the sealing body connecting portion 32 and the inner surface 15 of the rod-shaped component, and then enters the internal space 20 of the auxiliary component through the first medicine outlet 102, and then flows out from the second medicine outlet 202.

[0051] like Figure 1H As shown, it is a schematic diagram of embodiment 1 entering the anal canal A1, and the protrusion 242 on the auxiliary component 2 scrapes off the feces B or inflammatory secretions accumulated in the anal sinus A3; Figure 1I As shown in FIG. 1 , the liquid or paste-like medicine in the container cavity V0 enters the rectum after entering the anal canal A1; Figure 1J As shown, embodiment 1 is moved out of the anal canal A1, at which time the protrusion 242 on the auxiliary component 2 cleans the anal sinus A3 again, and the recess on the auxiliary component 2 brings the contained feces or inflammatory secretions out of the body (not shown in the figure).

[0052] Example 2:

[0053] like Figures 2A-2DAs shown, unlike the above-mentioned embodiment, the force-bearing portion 31 of the sealing body 3 is embedded in the head portion 23 of the auxiliary component, ensuring that it is not easily displaced by external forces during storage and transportation, thereby preventing the first drug outlet 102 from being opened unexpectedly; when in use, external force acts on the force-bearing portion 31 of the sealing body 3 through the head portion 23 of the auxiliary component to cause it to axially displace, drive the sealing portion 33 out of the sealing position, and open the first drug outlet 102; the auxiliary component is provided with a portion 221 that is easy to deform. In this embodiment, the portion 221 that is easy to deform is a multi-stage pine cone structure, which is easy to be compressed and deformed by external forces. When external force acts on the force-bearing portion 31 of the sealing body 3, the sealing portion 33 is driven to axially displace, so that the sealing portion 33 can easily disengage from the sealing position; as shown Figure 2B 、 2C As shown, the sealing body 3 is in a state where it is not pressed. At this time, the first medicine outlet 102 is closed by the sealing portion 33 of the sealing body 3, and the liquid or paste medicine F contained in the container cavity V0 cannot flow out; Figure 2D As shown, the sealing body 3 is in a state after being pressed. At this time, the sealing portion 33 of the sealing body 3 is axially displaced, the first medicine outlet 102 is opened, and the liquid or paste medicine F contained in the container cavity V0 first enters the gap 320 between the outer surface of the sealing body connecting portion 32 and the inner surface 15 of the rod-shaped component, and then flows out from the second medicine outlet 202.

[0054] Example 3:

[0055] like Figure 3A 、 3B As shown, unlike the above-mentioned embodiment, at least a part of the auxiliary component 2 is free to form a foldable portion 25 including a skirt shape, an umbrella shape, a leaf shape, and a bud shape. The connection between the foldable portion 25 and the auxiliary component 2 can be designed to be a connection that is not easy to separate. Specifically, the friction generated by entering and exiting the anal canal is not easy to separate; the foldable portion 25 can be deformed and moved within a certain range, and this deformation includes tensile deformation, bending deformation, folding deformation, etc. The foldable portion 25 can be provided with a secondary protrusion 251 and a secondary recess 252, which can fully wipe and remove feces, inflammatory secretions, etc. in the anal sinus and accommodate them in the recess and take them out of the body, which helps to eliminate constipation caused by anal sinus inflammation and helps to prevent and treat anal sinusitis after diarrhea. The secondary recess can also accommodate a certain amount of drugs with lubricating, cleaning, antibacterial and other functions; as shown in FIG. Figure 3A As shown, it is the state before the foldable part is folded; Figure 3B The figure shows the state where the foldable part is folded.

[0056] Example 4:

[0057] like Figure 4A 、 4BAs shown, the difference from Example 1 is that a fixing rib 34 is provided on the sealing body connecting portion 32, which can be in close contact with the rod-shaped component 1 at the first drug outlet 102. In this example, there are multiple fixing ribs 34 distributed vertically in the longitudinal direction. The gap 340 between two fixing ribs 34 can provide for the flow of medicine. The friction resistance generated by the close contact between the fixing rib 34 and the rod-shaped component 1 constrains the displacement of the sealing body 3, while not hindering the outflow of medicine. At the same time, it avoids the reset of the sealing portion 33 of the sealing body 3 that has been out of the sealing position due to the pressure of the medicine delivery, thereby ensuring the smooth injection of medicine. Figure 4A As shown, it is a schematic diagram of the sealing body 3 not being pressed. Figure 4B , which is a schematic diagram of the sealing body 3 after being pressed, the first drug outlet 102 is open, and the outer surface of the fixing rib 34 is in close contact with the inner surface of the drug channel 10 of the rod-shaped component 1.

[0058] Example 5:

[0059] like Figure 5 As shown, unlike Example 1, it further includes a restraining component C, which is annularly interference fit and is arranged on the outer surface of the tail 21 of the auxiliary component, so that the auxiliary component 2 is in close contact with the area corresponding to the head 13 of the rod-shaped component, to avoid the auxiliary component 2 from being separated from the rod-shaped component 1 due to friction or the like during the process of entering and exiting the anal canal, or because the seal between the auxiliary component 2 and the rod-shaped component 1 is not tight enough. After the first medicine outlet 102 is opened, the liquid or paste-like medicine F in the container cavity V0 is easy to flow out through the gap that may appear between the auxiliary component 2 and the rod-shaped component 1, and the restraining component C can further avoid the risk of the medicine flowing out of the gap.

Claims

1. A micro-opening anorectal drug delivery device with a drug outlet, comprising a rod-shaped component (1) with a hollow main body and an auxiliary component (2), wherein the main body of the rod-shaped component (1) is divided into a rod-shaped component tail portion (11), a rod-shaped component middle portion (12), and a rod-shaped component head portion (13), wherein the internal space of the rod-shaped component main body constitutes a drug channel (10) for delivering drugs, and the drug channel (10) is provided with at least one drug inlet (101) located at the bottom end of the rod-shaped component tail portion (11) and at least one first drug outlet (102) located at the rod-shaped component head portion (13). 02); the auxiliary component (2) has a hollow cap-like main body, which is divided into an auxiliary component tail (21), an auxiliary component middle part (22), and an auxiliary component head (23); the auxiliary component (2) is at least sleeved on the rod-shaped component head (13), that is, the rod-shaped component head (13) is covered in the auxiliary component internal space (20); the auxiliary component (2) is provided with at least one second drug outlet (202) communicating with the auxiliary component internal space (20); the hardness of the material of the auxiliary component (2) is lower than that of the rod-shaped component (1), and is characterized in that: The invention also includes a sealing body (3) partially embedded in or completely covered in the internal space (20) of the auxiliary component. The sealing body (3) is divided into a force-bearing part (31), a connecting part (32), and a sealing part (33). The sealing part (33) of the sealing body (3) enters the drug channel (10) through the first drug outlet (102), thereby closing the first drug outlet (102) to the outside. When in use, an external force directly or indirectly acts on the force-bearing part (31) of the sealing body (3), so that the sealing part (33) is driven to axially displace and thus leave the sealing position. The first drug outlet (102) is opened, and the liquid or paste-like medicine entering the drug channel (10) first flows out through the first drug outlet (102) and then through the second drug outlet (202) opened on the auxiliary component (2).

2. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The force-bearing portion (31) of the sealing body (3) protrudes through the top opening (230) of the auxiliary component head (23). When in use, the force-bearing portion (31) of the sealing body (3) is directly pressed to cause it to move axially, driving the sealing portion (33) out of the sealing position, and the first medicine outlet (102) is opened.

3. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The force-bearing portion (31) of the sealing body (3) is embedded in the auxiliary component head (23). When in use, external force acts on the force-bearing portion (31) of the sealing body (3) through the auxiliary component head (23) to cause it to move axially, driving the sealing portion (33) out of the sealing position, and the first medicine outlet (102) is opened.

4. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The outer surface (14) of the rod-shaped component is provided with an annular convex rib (141) for preventing the auxiliary component (2) sleeved thereon from being separated under the action of external force.

5. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The auxiliary component (2) is provided with protrusions (242) including strips, nails, bosses, hooks, water drops, stripes, scattered dots, serrations, beads, wrinkles, terraces, burrs, and continuous spirals, and / or depressions (243) capable of accommodating medicine and feces.

6. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: At least a portion of the auxiliary component (2) is free to become a foldable portion (25) including a skirt shape, an umbrella shape, a leaf shape, and a bud shape.

7. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The sealing body (3) is provided with a fixing rib (34) which can be in close contact with the rod-shaped component (1) at the first drug outlet (102). After the fixing rib (34) is in close contact with the rod-shaped component (1), the displacement of the sealing body (3) is restricted, thereby preventing the sealing portion (33) of the sealing body (3) which has been separated from the sealing position from being reset due to the pressure of the drug delivery without hindering the outflow of the drug.

8. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The auxiliary component is provided with a portion (221) that is easily deformed, so that when an external force acts on the force-bearing portion (31) of the sealing body (3), it is easy to drive the sealing portion (33) to axially displace, so that the sealing portion (33) can easily leave the sealing position and the first medicine outlet (102) is opened.

9. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: The invention also comprises a restraining component (C) which is sleeved on the outer surface of the tail portion (21) of the auxiliary component so as to be in close contact with the area corresponding to the rod-shaped component.

10. The anorectal drug delivery device with a micro-opening drug outlet according to claim 1, characterized in that: It also includes a container (V) that can be sealed and connected to the rod-shaped component tail (11) or is integrally formed, and the container cavity (V0) contains liquid or paste-like medicine.

Images