Apparatus and method for treating tumors with rotating alternating electric field

Abstract

The application relates to the technical field of medical devices, and provides a device and a method for treating tumors by using a rotating alternating electric field, wherein the device comprises a host computer control unit, two MCU control units and an electrode pair; the host computer control unit is connected with the electrode pair through the MCU control units; the two electrode pairs are vertically arranged around a tumor lesion; the host computer control unit generates waveform control parameters based on the shape of the tumor lesion; the MCU control units further generate waveform signals with alternating amplitudes and convert the waveform signals into analog signals to be transmitted to the electrode pair to generate a rotating alternating electric field around the lesion. The device for treating tumors by using a rotating alternating electric field can make the electric field generated by the electrode pair rotate 360 degrees around the lesion for sufficient treatment, can adjust the strength of the electric field without changing the setting of the electrode pair, can generate different electric fields according to the shape of the tumor lesion and superimpose the different electric fields to form a targeted electric field for treatment, and can achieve a better treatment effect.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to a device and method for treating tumors using a rotating alternating electric field. Background Technology

[0002] Tumor treating fields (TTF), also known as tumor therapeutic electric fields, is a novel cancer treatment method. Its mechanism of action primarily involves interfering with and disrupting cell mitosis, thereby inhibiting the growth and proliferation of cancer cells and ultimately suppressing tumor growth. The alternating electric field used to treat cancer cells has an optimal frequency for different cell types and sizes.

[0003] Currently available TTF treatment solutions mostly use a single-frequency electric field, or spatially superimpose multiple frequencies of electric fields on different electrodes. In the process of developing this application, the inventors discovered the following problems with the prior art:

[0004] 1. Superimposing an electric field on different electrodes can easily lead to electrode waste and reduce the maintainability of the equipment;

[0005] 2. Currently, the TTF rotating electric field therapy is achieved by changing the phase of the electrodes. Its disadvantage is that since the amplitude is fixed, the amplitude of the superimposed electrodes changes after the electric field rotates once, resulting in a large change in the electric field intensity. Specifically, when the phase difference between the two electrodes is 0, the electric field intensity is twice that of the electric field generated by a single electrode, while when the phase difference between the two electrodes is π, the superimposed electric field intensity is 0. The change in electric field intensity will also affect the treatment effect.

[0006] 3. Currently, it is not possible to adjust the amplitude at different angles according to the actual shape of the lesion, thereby achieving a targeted treatment effect. Summary of the Invention

[0007] To address the shortcomings of the existing technology, this invention provides a device and method for treating tumors with a rotating alternating electric field. This solves the technical problem in the prior art that it is impossible to reduce the number of electrodes and adjust the amplitude at different angles to generate different rotating electric fields according to the actual shape of the lesion for targeted treatment.

[0008] This invention provides a device for treating tumors using a rotating alternating electric field, comprising:

[0009] Host computer control unit, first MCU control unit, second MCU control unit, first electrode pair and second electrode pair;

[0010] The host computer control unit is connected to the first electrode pair through the first MCU control unit, and the host computer control unit is also connected to the second electrode pair through the second MCU control unit. The first electrode pair and the second electrode pair are vertically arranged around the tumor lesion.

[0011] The host computer control unit generates waveform control parameters based on the shape of the tumor lesion. The first MCU control unit and the second MCU control unit respectively generate waveform signals with continuously alternating amplitudes based on the waveform control parameters, and convert the waveform signals into analog signals and transmit them to the corresponding connected first electrode pair and second electrode pair, so that the first electrode pair and the second electrode pair generate a rotating alternating electric field around the tumor lesion.

[0012] The device for treating tumors with a rotating alternating electric field also includes a feature extraction unit;

[0013] The feature extraction unit is connected to the host computer control unit. The feature extraction unit is used to extract features from the tumor lesion and establish a three-dimensional model of the tumor lesion. Then, based on the three-dimensional model, the aspect ratio of the tumor lesion is obtained, and based on the aspect ratio of the tumor lesion, the shape information of the tumor lesion is obtained. The shape information is then transmitted to the host computer control unit.

[0014] When the aspect ratio of the tumor lesion is equal to 1, that is, the shape of the tumor lesion is roughly circular;

[0015] When the aspect ratio of the tumor lesion is greater than 1, the shape of the tumor lesion is elliptical.

[0016] The device for treating tumors with a rotating alternating electric field provided by this invention arranges two electrode pairs vertically around the tumor lesion. The host computer control unit controls the MCU control unit to generate different waveform signals according to the shape of the tumor lesion. By modulating the frequency and amplitude of the signals, the electric field generated by the two electrode pairs can rotate 360 ​​degrees around the tumor lesion, effectively treating it. Furthermore, without changing the electrode pair arrangement, the strength of the electric field can be adjusted, and different electric fields generated according to the shape of the tumor lesion can be superimposed to form a targeted electric field for treatment, achieving better therapeutic effects. The device provided in this application generates a rotating electric field with a constant amplitude through amplitude variation, and can also adjust the amplitude according to the actual shape of the tumor lesion to optimize the treatment effect. Through waveform superposition, it can simultaneously and specifically treat multiple tumor cells while reducing the number of electrodes.

[0017] The rotating alternating electric field method for tumor treatment provided by this invention classifies tumor lesions into round and elliptical shapes. For round tumor lesions, a host computer control unit and two MCU control units control two electrode pairs to generate two circular rotating electric fields with different amplitudes and frequencies. For elliptical tumor lesions, the host computer control unit and two MCU control units control two electrode pairs to generate one elliptical rotating electric field, or generate two elliptical rotating electric fields with different amplitudes and frequencies. This method generates corresponding rotating electric fields based on two different tumor lesion shapes for targeted treatment, achieving better therapeutic effects.

[0018] Other features and advantages of the invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. The objects and other advantages of the invention may be realized and obtained by means of the structures particularly pointed out in the written description, claims, and drawings.

[0019] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings and embodiments. Attached Figure Description

[0020] The accompanying drawings are provided to further illustrate the invention and form part of the specification. They are used in conjunction with embodiments of the invention to explain the invention and do not constitute a limitation thereof. In the drawings:

[0021] Figure 1 A schematic diagram of a device for treating tumors using a rotating alternating electric field, provided in one embodiment of this application;

[0022] Figure 2 A schematic diagram of the cosine shape of a waveform signal in one embodiment provided in this application;

[0023] Figure 3 A schematic diagram of the sinusoidal shape of a waveform signal provided in one embodiment of this application;

[0024] Figure 4 A schematic diagram showing the field strength and direction of a circular rotating electric field in one embodiment provided in this application;

[0025] Figure 5 A schematic diagram of the field strength and direction of an elliptical rotating electric field in one embodiment provided in this application. Detailed Implementation

[0026] In the description of this invention, it should be understood that the terms "center," "longitudinal," "lateral," "length," "width," "thickness," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," "clockwise," and "counterclockwise," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are only for the convenience of describing this invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this invention.

[0027] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of this invention, "a plurality of" means two or more, unless otherwise explicitly specified.

[0028] In this invention, unless otherwise explicitly specified and limited, the terms "installation," "connection," "linking," and "fixing," etc., should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this invention according to the specific circumstances.

[0029] This invention provides a device for treating tumors using a rotating alternating electric field, such as... Figure 1 As shown, the system includes a host computer control unit, a first MCU control unit, a second MCU control unit, a first electrode pair, and a second electrode pair. The host computer control unit is connected to the first electrode pair via the first MCU control unit, and is also connected to the second electrode pair via the second MCU control unit. The first electrode pair and the second electrode pair are vertically arranged around the tumor lesion. The host computer control unit generates waveform control parameters based on the shape of the tumor lesion. The first MCU control unit and the second MCU control unit respectively generate waveform signals with continuously alternating amplitudes based on the waveform control parameters, and convert the waveform signals into analog signals and transmit them to the corresponding connected first electrode pair and second electrode pair, so that the first electrode pair and the second electrode pair generate a rotating alternating electric field around the tumor lesion.

[0030] The device for treating tumors with a rotating alternating electric field provided by this invention arranges two electrode pairs vertically around the tumor lesion. The host computer control unit controls the MCU control unit to generate different waveform signals according to the shape of the tumor lesion. By modulating the frequency and amplitude of the signals, the electric field generated by the two electrode pairs can rotate 360 ​​degrees around the tumor lesion, effectively treating it. Furthermore, without changing the electrode pair arrangement, the strength of the electric field can be adjusted, and different electric fields generated according to the shape of the tumor lesion can be superimposed to form a targeted electric field for treatment, achieving better therapeutic effects. The device provided in this application generates a rotating electric field with a constant amplitude through amplitude variation, and can also adjust the amplitude according to the actual shape of the tumor lesion to optimize the treatment effect. Through waveform superposition, it can simultaneously and specifically treat multiple tumor cells while reducing the number of electrodes.

[0031] Furthermore, both the first MCU control unit and the second MCU control unit include two sets of interconnected frequency amplitude control modules and digital-to-analog conversion modules. The input terminal of the frequency amplitude control module is connected to the output terminal of the host computer control unit, and the output terminal of the digital-to-analog conversion module is connected to the corresponding electrode pair of its respective MCU control unit. Specifically, one set of frequency amplitude control modules in the first MCU control unit generates a first waveform signal based on waveform control parameters, and its corresponding digital-to-analog conversion module converts the first waveform signal into a first analog signal and transmits it to the first electrode pair. The other set of frequency amplitude control modules in the first MCU control unit generates a second waveform signal based on waveform control parameters, and its corresponding digital-to-analog conversion module converts the second waveform signal into a second analog signal and transmits it to the first electrode pair. One set of frequency amplitude control modules in the second MCU control unit generates a third waveform signal based on waveform control parameters, and its corresponding digital-to-analog conversion module converts the third waveform signal into a third analog signal and transmits it to the second electrode pair. The other set of frequency amplitude control modules in the second MCU control unit generates a fourth waveform signal based on waveform control parameters, and its corresponding digital-to-analog conversion module converts the fourth waveform signal into a fourth analog signal and transmits it to the second electrode pair.

[0032] In this embodiment, the frequency amplitude control module in the MCU control unit generates a waveform signal based on waveform control parameters and modulates the amplitude of the waveform signal to make the amplitude continuously change. The waveform signal is then converted into an analog signal by a digital-to-analog converter before being transmitted to the electrode pair. By modulating the amplitude of the waveform signal, the electric field rotates at a certain frequency. Furthermore, through frequency superposition, the electric field can rotate in an elliptical shape in any direction. When the force lines of the external electric field are parallel to the long axis of the dividing cell, the cell membrane at the mitotic groove is prone to rupture. However, the actual distribution of tumor cells is disordered, with the long axis directions of each tumor dividing cell being random. Therefore, when the electric field rotates at a certain frequency, it can ensure that tumors in all directions can be effectively treated. Moreover, the rotating electric field can adjust its direction according to the specific morphology of the tumor to achieve a more precise treatment effect.

[0033] Furthermore, the device for treating tumors with a rotating alternating electric field also includes a signal superposition and amplification unit. This unit comprises two sets of frequency superposition and amplification modules, an amplification module, and a current detection module connected sequentially. The input terminal of one set of frequency superposition and amplification modules is connected to a first MCU control unit, used to superimpose and amplify a first analog signal and a second analog signal to generate a first amplified signal. The amplification module amplifies the first amplified signal to generate a first output signal, which is then transmitted to the first electrode pair via the current detection module. The current detection module is also connected to the first MCU control unit, used to detect the output current of the amplification module and feed the detection result back to the first MCU control unit. The input terminal of the other set of frequency superposition and amplification modules is connected to a second MCU control unit, used to superimpose and amplify a third analog signal and a fourth analog signal to generate a second amplified signal. The amplification module amplifies the second amplified signal to generate a second output signal, which is then transmitted to the second electrode pair via the current detection module. The current detection module is also connected to the second MCU control unit, used to detect the output current of the amplification module and feed the detection result back to the second MCU control unit.

[0034] In this embodiment, the frequency superposition amplification module, the amplification module, and the current detection module are connected in sequence. Specifically, the frequency superposition amplification module is an adder amplifier circuit composed of a high-frequency operational amplifier. After receiving two analog signals output by the connected MCU control unit, it superimposes and amplifies them to generate an amplified signal, which is then transmitted to the amplification module. The amplification module is a high-voltage high-frequency operational amplifier, which amplifies the input signal again to obtain an output signal. The output signal is transmitted to the current detection module. On the one hand, the current detection module transmits the output signal to the respective connected electrode pairs to generate an electric field. On the other hand, the current detection module transmits the output signal to the MCU control unit connected to the signal superposition amplification unit. The current detection module is used to detect the magnitude of the output current between the amplification module and the electrode pairs and feeds back the detection result to the MCU control unit, so that the MCU control unit can adjust the output signal parameters.

[0035] Furthermore, when the tumor lesion is roughly circular in shape, the waveform control parameters include amplitude and angular frequency;

[0036] The amplitude of the first waveform signal varies according to a cosine law, such as... Figure 2 As shown, its function expression is:

[0037]

[0038] in, The actual output amplitude of the first waveform signal. For amplitude, Angular frequency;

[0039] The amplitude of the second waveform signal varies according to a cosine law, and its function expression is:

[0040]

[0041] in, This represents the actual output amplitude of the second waveform signal. For amplitude, Angular frequency;

[0042] The third waveform signal has the same output frequency and waveform as the first waveform signal, such as... Figure 3 As shown, the amplitude of the third waveform signal varies sinusoidally, and its function expression is:

[0043]

[0044] in, This represents the actual output amplitude of the third waveform signal. For amplitude, Angular frequency;

[0045] The fourth waveform signal has the same output frequency and waveform as the second waveform signal. The amplitude of the fourth waveform signal varies sinusoidally, and its function expression is:

[0046]

[0047] in, This represents the actual output amplitude of the fourth waveform signal. For amplitude, Angular frequency;

[0048] The vertically positioned first and second electrode pairs generate two circular rotating electric fields after receiving the superimposed first and second output signals, respectively. The amplitude of the field strength of one of the circular rotating electric fields is... The frequency is Its amplitude expression is:

[0049]

[0050] The amplitude of the electric field strength of the other circular rotating electric field is The frequency is Its amplitude expression is:

[0051] .

[0052] In this embodiment, the four frequency amplitude control modules of this application generate four waveform signals with regularly changing amplitudes based on waveform control parameters. The first electrode pair is superimposed with the first and second waveform signals, and the second electrode pair is superimposed with the third and fourth waveform signals. The first electrode pair and the second electrode pair are at a 90° angle. The electrodes are set vertically, thus generating two superimposed electric fields. The first electrode pair is along the x-axis, and the second electrode pair is along the y-axis. As shown in the formula, the two electric fields are respectively along the x-axis and y-axis. , As amplitude, , A circular rotating electric field with frequency , such as Figure 4 As shown, the device provided in this application only requires two pairs of electrodes to rotate the direction of the electric field at a certain speed, and superimpose two circular electric fields of different amplitudes and frequencies onto the area where the tumor lesion is located according to the shape of the tumor lesion. This achieves the superposition of electric fields with corresponding shapes, amplitudes, and frequencies that match the shape of the lesion, so as to obtain better treatment results.

[0053] Specifically, in the above embodiments, when the shape of the tumor lesion is elliptical, the waveform control parameters include amplitude, angular frequency, and the deflection angle of the major axis of the elliptical tumor lesion relative to the electrode pair.

[0054] The amplitude of the first waveform signal varies according to a cosine law, and its function expression is:

[0055]

[0056] in, The actual output amplitude of the first waveform signal. For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0057] The second waveform signal has the same output frequency and waveform as the first waveform signal. The amplitude of the second waveform signal varies sinusoidally, and its function expression is:

[0058]

[0059] in, This represents the actual output amplitude of the second waveform signal. For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0060] The third waveform signal has the same output frequency and waveform as the first waveform signal. The amplitude of the third waveform signal varies according to a cosine law, and its function expression is:

[0061]

[0062] in, This represents the actual output amplitude of the third waveform signal. For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0063] The fourth waveform signal has the same output frequency and waveform as the first waveform signal. The amplitude of the fourth waveform signal varies sinusoidally, and its function expression is:

[0064]

[0065] in, This represents the actual output amplitude of the fourth waveform signal. For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0066] The vertically positioned first and second electrode pairs, after receiving the superimposed first and second output signals respectively, generate an elliptical rotating electric field with a frequency of . The major axis of the elliptical electric field is The minor axis of the elliptical electric field is Its amplitude expression is:

[0067] .

[0068] In this embodiment, during actual treatment, the shape of the tumor lesion is usually not a regular, near-circular shape, but rather an elliptical shape with both major and minor axes. For the treatment of near-elliptical tumor lesions, an elliptical rotating electric field can be set according to the shape of the tumor lesion, such as... Figure 5 As shown, specifically, the shape of the electric field is a series of... , An ellipse with amplitudes equal to its major and minor axes, and , The ratio of the two values ​​is equal to the aspect ratio of the oval tumor lesion, and the frequency is [missing value]. The device of this application only requires two pairs of electrodes to generate an elliptical rotating electric field, and rotates the elliptical electric field at a certain speed. Furthermore, the shape of the elliptical electric field and its angle relative to the x-axis can be controlled according to the shape of the specific tumor lesion and its angle relative to the first electrode pair. The value of is determined to ensure that the electric field strength received by the tumor lesion is consistent in every direction, thereby ensuring that the oval tumor lesion as a whole can achieve better treatment results.

[0069] Specifically, in the above embodiments, the device for treating tumors with a rotating alternating electric field further includes a power supply module, wherein the power supply module is connected to the first MCU control unit, the second MCU control unit, the first electrode pair, the second electrode pair and the signal superposition and amplification unit, respectively, for supplying power.

[0070] In this embodiment, the power module can use AC power and be directly connected to AC power for power supply, which provides a stable power supply and facilitates long-term use. In some usage scenarios, this device needs to be carried around for use, so the power module can also be a battery. In the case where there is no AC power available, the battery can continuously provide power support for each functional unit and module in the device for 4-8 hours, thereby improving the device's battery life and enriching the device's usage scenarios.

[0071] Specifically, in the above embodiments, both the first MCU control unit and the second MCU control unit include a superposition calculation module. The input terminal of the superposition calculation module in the first MCU control unit is connected to the host computer control unit, and the output terminal of the superposition calculation module in the first MCU control unit is connected to the first electrode pair. The superposition calculation module is used to perform calculations based on waveform control parameters to obtain a first waveform signal and a second waveform signal, and then superimpose them. The superimposed signal is then transmitted to the first electrode pair in the form of an analog signal. The input terminal of the superposition calculation module in the second MCU control unit is connected to the host computer control unit, and the output terminal of the superposition calculation module in the second MCU control unit is connected to the second electrode pair. The superposition calculation module is used to perform calculations based on waveform control parameters to obtain a third waveform signal and a fourth waveform signal, and then superimpose them. The superimposed signal is then transmitted to the second electrode pair in the form of an analog signal.

[0072] When the shape of the tumor lesion is elliptical, the waveform control parameters include amplitude, angular frequency, and the deflection angle of the major axis of the elliptical tumor lesion relative to the electrode pair.

[0073] The amplitude function expression for the first waveform signal is:

[0074]

[0075] The amplitude function expression for the third waveform signal is:

[0076]

[0077] in, The actual output amplitude of the first waveform signal. This represents the actual output amplitude of the third waveform signal. , For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0078] The amplitude function expression for the second waveform signal is:

[0079]

[0080] The amplitude function expression for the fourth waveform signal is:

[0081]

[0082] in, This represents the actual output amplitude of the second waveform signal. This represents the actual output amplitude of the fourth waveform signal. , For amplitude, Angular frequency, The angle of deflection of the long axis of the elliptical tumor lesion relative to the first electrode pair;

[0083] The vertically positioned first and second electrode pairs generate two elliptical rotating electric fields after receiving analog signals, one of which has a frequency of... Its major axis is The minor axis is Its amplitude expression is:

[0084]

[0085] The frequency of the other elliptical rotating electric field is Its major axis is The minor axis is Its amplitude expression is:

[0086] .

[0087] In this embodiment, when targeting an elliptical tumor lesion, the device of this application superimposes an elliptical electric field through the MCU control unit and the signal superposition and amplification unit, so that the tumor lesion can be treated from all angles. Simultaneously, the device of this application can also directly perform calculation and superposition through the superposition calculation module in the MCU control unit, and then directly output the superimposed waveform. The output amplitude expressions of each waveform are given by the above formula, thereby making the frequency of the first waveform signal and the third waveform signal together be... ,by With the major axis, The electric field is an elliptical rotating field with a minor axis, and the second and fourth waveform signals together form a frequency of... ,by With the major axis, An elliptical rotating electric field with a short axis, when two elliptical rotating electric fields with different amplitudes and frequencies are superimposed on the tumor lesion area, can achieve better treatment results.

[0088] Specifically, in the above embodiments, a temperature acquisition module is provided on both the first electrode pair and the second electrode pair. The temperature acquisition module is connected to the MCU control unit corresponding to the electrode pair. The temperature acquisition module is used to acquire the temperature data of the first electrode pair and the second electrode pair and feed the temperature data back to the corresponding first MCU control unit and second MCU control unit so that the first MCU control unit and the second MCU control unit adjust the amplitude of the output signal according to the temperature data.

[0089] In this embodiment, the temperature acquisition module is specifically a temperature sensor, which is installed inside the first electrode pair and the second electrode pair. It can acquire the temperature data of the two electrode pairs in real time and feed the temperature data of the electrode pairs back to their respective MCU control units in a timely manner. An alarm temperature can be preset in the MCU control unit. When the temperature acquisition module acquires the temperature of the electrode pair higher than the alarm temperature, an alarm is triggered. At the same time, the MCU control unit can also adjust the amplitude of the output signal according to the temperature data to reduce the output power, so as to avoid burns to the patient's skin due to excessive temperature and prevent accidents, thereby improving the safety of the device.

[0090] Specifically, in the above embodiments, the device for treating tumors with a rotating alternating electric field further includes a feature extraction unit. The feature extraction unit is connected to the host computer control unit. The feature extraction unit is used to extract features from the tumor lesion and establish a three-dimensional model of the tumor lesion. Then, based on the three-dimensional model, the aspect ratio of the tumor lesion is obtained, and based on the aspect ratio of the tumor lesion, the shape information of the tumor lesion is obtained. The shape information is then transmitted to the host computer control unit. When the aspect ratio of the tumor lesion is equal to 1, the shape of the tumor lesion is roughly circular. When the aspect ratio of the tumor lesion is greater than 1, the shape of the tumor lesion is roughly elliptical.

[0091] In this embodiment, the feature extraction unit specifically employs conventional medical equipment and uses conventional detection methods for tumor cell images, such as CT, MRI, and PET, to extract features of the size, shape, and morphology of the tumor lesion, and establish a three-dimensional model of the tumor lesion. Then, based on the three-dimensional model, the aspect ratio of the tumor lesion is obtained. Specifically, when the aspect ratio of the detected tumor cell lesion is approximately 1, the shape of the tumor lesion can be considered roughly circular; when the aspect ratio of the detected tumor lesion is greater than 1, the shape of the tumor lesion can be considered roughly elliptical. This application classifies the shape of tumor lesions into roughly circular and roughly elliptical shapes. There are two types of lesions, circular and circular. The shape information of the lesion is then transmitted to the host computer control unit. The host computer control unit determines the basic information such as the characteristic frequency and field strength of the electric field based on the shape of the lesion. Different electric fields are generated for targeted treatment of cell lesions with different shapes. After a certain period of treatment, by extracting the characteristic parameters again and according to the actual shape change of the lesion, the host computer can change the corresponding electric field parameters in real time without adjusting the position and number of electrodes. The changes are then transmitted to the electrodes to adjust the various parameters and shape of the rotating electric field according to the actual shape of the lesion and the treatment effect, so as to achieve better treatment results.

[0092] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A device for treating tumors using a rotating alternating electric field, characterized in that, include: Host computer control unit, first MCU control unit, second MCU control unit, first electrode pair and second electrode pair; The host computer control unit is connected to the first electrode pair through the first MCU control unit, and the host computer control unit is also connected to the second electrode pair through the second MCU control unit. The first electrode pair and the second electrode pair are arranged vertically around the tumor lesion. The host computer control unit generates waveform control parameters based on the shape of the tumor lesion. The first MCU control unit and the second MCU control unit respectively generate waveform signals with continuously alternating amplitudes based on the waveform control parameters, and convert the waveform signals into analog signals and transmit them to the corresponding connected first electrode pair and second electrode pair, so that the first electrode pair and the second electrode pair generate a rotating alternating electric field around the tumor lesion. The device for treating tumors with a rotating alternating electric field also includes a feature extraction unit; The feature extraction unit is connected to the host computer control unit. The feature extraction unit is used to extract features from the tumor lesion and establish a three-dimensional model of the tumor lesion. Then, based on the three-dimensional model, the aspect ratio of the tumor lesion is obtained, and based on the aspect ratio of the tumor lesion, the shape information of the tumor lesion is obtained. The shape information is then transmitted to the host computer control unit. When the aspect ratio of the tumor lesion is equal to 1, that is, the shape of the tumor lesion is roughly circular; When the aspect ratio of the tumor lesion is greater than 1, the shape of the tumor lesion is elliptical.

2. The device for treating tumors using a rotating alternating electric field according to claim 1, characterized in that, Both the first MCU control unit and the second MCU control unit include two sets of frequency amplitude control modules and digital-to-analog conversion modules connected to each other. The input terminal of the frequency amplitude control module is connected to the output terminal of the host computer control unit, and the output terminal of the digital-to-analog conversion module is connected to the corresponding electrode pair connected to its MCU control unit. A set of frequency amplitude control modules in the first MCU control unit generates a first waveform signal based on the waveform control parameters, and the corresponding digital-to-analog conversion module converts the first waveform signal into a first analog signal and transmits it to the first electrode pair. Another set of frequency amplitude control modules in the first MCU control unit generates a second waveform signal based on the waveform control parameters, and the corresponding digital-to-analog conversion module converts the second waveform signal into a second analog signal and transmits it to the first electrode pair; A set of frequency amplitude control modules in the second MCU control unit generates a third waveform signal based on the waveform control parameters, and the corresponding digital-to-analog conversion module converts the third waveform signal into a third analog signal and transmits it to the second electrode pair. Another set of frequency amplitude control modules in the second MCU control unit generates a fourth waveform signal based on the waveform control parameters, and the corresponding digital-to-analog conversion module converts the fourth waveform signal into a fourth analog signal and transmits it to the second electrode pair.

3. The device for treating tumors using a rotating alternating electric field according to claim 2, characterized in that, The device for treating tumors with a rotating alternating electric field also includes a signal superposition and amplification unit, which comprises two sets of frequency superposition and amplification modules, an amplification module and a current detection module connected in sequence. The input terminal of one of the frequency superposition amplification modules is connected to the first MCU control unit, and is used to superimpose and amplify the first analog signal and the second analog signal to generate a first amplified signal. The amplification module is used to amplify the first amplified signal to generate a first output signal, and transmit it to the first electrode pair through the current detection module. The current detection module is also connected to the first MCU control unit, and is used to detect the output current of the amplification module and feed back the detection result to the first MCU control unit. The input terminal of the frequency superposition amplification module of the other group is connected to the second MCU control unit, and is used to superimpose and amplify the third analog signal and the fourth analog signal to generate a second amplified signal. The amplification module is used to amplify the second amplified signal to generate a second output signal, and transmit it to the second electrode pair through the current detection module. The current detection module is also connected to the second MCU control unit, and is used to detect the output current of the amplification module and feed back the detection result to the second MCU control unit.

4. The device for treating tumors using a rotating alternating electric field according to claim 3, characterized in that, When the shape of the tumor lesion is roughly circular, the waveform control parameters include amplitude and angular frequency; The amplitude of the first waveform signal varies according to a cosine law, and its functional expression is: in, The actual output amplitude of the first waveform signal. For amplitude, ω is the angular frequency, and t is time; The amplitude of the second waveform signal varies according to a cosine law, and its function expression is: in, This represents the actual output amplitude of the second waveform signal. For amplitude, ω is the angular frequency, and t is time; The third waveform signal has the same output frequency and waveform as the first waveform signal, and the amplitude of the third waveform signal varies sinusoidally, with the following function expression: in, The actual output amplitude of the third waveform signal. For amplitude, ω is the angular frequency, and t is time; The fourth waveform signal has the same output frequency and waveform as the second waveform signal, and the amplitude of the fourth waveform signal varies sinusoidally, with the following function expression: in, The actual output amplitude of the fourth waveform signal. For amplitude, ω is the angular frequency, and t is time; The vertically positioned first and second electrode pairs generate two circular rotating electric fields after receiving the superimposed first and second output signals, respectively. The amplitude of the field strength of one of the circular rotating electric fields is... The frequency is The time is t, and its amplitude expression is: The amplitude of the electric field strength of the other circular rotating electric field is The frequency is The time is t, and its amplitude expression is: 。 5. The device for treating tumors using a rotating alternating electric field according to claim 3, characterized in that, When the shape of the tumor lesion is elliptical, the waveform control parameters include amplitude, angular frequency, and the deflection angle of the major axis of the elliptical tumor lesion relative to the electrode pair. The amplitude of the first waveform signal varies according to a cosine law, and its functional expression is: in, The actual output amplitude of the first waveform signal. For amplitude, Let t be the angular frequency and t be the time. The angle of deflection of the major axis of the elliptical tumor lesion relative to the first electrode pair; The second waveform signal has the same output frequency and waveform as the first waveform signal. The amplitude of the second waveform signal varies sinusoidally, and its function expression is: in, This represents the actual output amplitude of the second waveform signal. For amplitude, Let t be the angular frequency and t be the time. The angle of deflection of the major axis of the elliptical tumor lesion relative to the first electrode pair; The third waveform signal has the same output frequency and waveform as the first waveform signal, and the amplitude of the third waveform signal varies according to a cosine law, with the function expression being: in, The actual output amplitude of the third waveform signal. For amplitude, Let t be the angular frequency and t be the time. The angle of deflection of the major axis of the elliptical tumor lesion relative to the first electrode pair; The fourth waveform signal has the same output frequency and waveform as the first waveform signal, and the amplitude of the fourth waveform signal varies sinusoidally, with the following function expression: in, The actual output amplitude of the fourth waveform signal. For amplitude, Let t be the angular frequency and t be the time. The angle of deflection of the major axis of the elliptical tumor lesion relative to the first electrode pair; The vertically positioned first electrode pair and second electrode pair, after receiving the superimposed first and second output signals respectively, generate an elliptical rotating electric field with a frequency of . The major axis of the elliptical electric field is The minor axis of the elliptical electric field is The time is t, and its amplitude expression is: 。 6. The apparatus for treating tumors using a rotating alternating electric field according to claim 3, characterized in that, The device for treating tumors with a rotating alternating electric field also includes a power supply module; The power module is connected to the first MCU control unit, the second MCU control unit, the first electrode pair, the second electrode pair and the signal superposition and amplification unit respectively, and is used to provide power.

7. The apparatus for treating tumors using a rotating alternating electric field according to claim 1, characterized in that, Both the first MCU control unit and the second MCU control unit include an overlay calculation module; The input terminal of the superposition calculation module in the first MCU control unit is connected to the host computer control unit, and the output terminal of the superposition calculation module in the first MCU control unit is connected to the first electrode pair. The superposition calculation module is used to perform calculations based on the waveform control parameters to obtain the first waveform signal and the second waveform signal and superimpose them, and then transmit the superimposed signal to the first electrode pair in the form of an analog signal. The input terminal of the superposition calculation module in the second MCU control unit is connected to the host computer control unit, and the output terminal of the superposition calculation module in the second MCU control unit is connected to the second electrode pair. The superposition calculation module is used to perform calculations based on the waveform control parameters to obtain the third waveform signal and the fourth waveform signal and superimpose them, and then transmit the superimposed signal to the second electrode pair in the form of an analog signal. When the shape of the tumor lesion is elliptical, the waveform control parameters include amplitude, angular frequency, and the deflection angle of the major axis of the elliptical tumor lesion relative to the electrode pair. The amplitude function expression of the first waveform signal is: The amplitude function expression of the third waveform signal is: in, The actual output amplitude of the first waveform signal. The actual output amplitude of the third waveform signal. , For amplitude, Angular frequency, t is the deflection angle of the major axis of the elliptical tumor lesion relative to the first electrode pair; The amplitude function expression for the second waveform signal is: The amplitude function expression of the fourth waveform signal is: in, This represents the actual output amplitude of the second waveform signal. The actual output amplitude of the fourth waveform signal. , For amplitude, Angular frequency, The angle of deflection of the major axis of the elliptical tumor lesion relative to the first electrode pair is t, where t is time. The vertically positioned first and second electrode pairs generate two elliptical rotating electric fields after receiving the analog signal, one of which has a frequency of... Its major axis is The minor axis is The time is t, and its amplitude expression is: The frequency of the other elliptical rotating electric field is Its major axis is The minor axis is The time is t, and its amplitude expression is: 。 8. The apparatus for treating tumors using a rotating alternating electric field according to claim 1, characterized in that, Both the first electrode pair and the second electrode pair are equipped with a temperature acquisition module, and the temperature acquisition module is connected to the MCU control unit corresponding to the electrode pair. The temperature acquisition module is used to acquire temperature data of the first electrode pair and the second electrode pair, and feed the temperature data back to the corresponding first MCU control unit and second MCU control unit, so that the first MCU control unit and the second MCU control unit adjust the amplitude of the output signal according to the temperature data.

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