Drug-loaded auxiliary treatment denture and processing method thereof

Abstract

This invention discloses a drug-loadable therapeutic prosthesis and its processing method, comprising an implant, an abutment, and an artificial crown located on the abutment; the abutment is connected to the implant via a threaded structure; the outer surface of the implant has an external threaded structure; the implant contains a drug reservoir for temporary drug storage and a drug delivery tube for drug discharge; the drug delivery tube is connected to the end of the drug reservoir. This drug-loadable therapeutic prosthesis of the present invention has multiple therapeutic functions including sustained-release drug delivery, anti-inflammatory effects, and hemostasis promotion, and is simple, stable, and convenient to use.

Description

Technical Field

[0001] This invention relates to the field of implant technology, and in particular to a drug-loadable adjunctive treatment denture and its processing method. Background Technology

[0002] Tooth loss is a common oral health problem. With the improvement of people's living standards, dental implants have become a major means of treating tooth loss. Dental implants, also known as implant prostheses, include an implant body, abutment, screw, and crown. The implant body has a vertically threaded hole in its center, and the abutment has a vertically oriented groove in its center. A through hole is located at the bottom of the groove. The screw is placed in the groove, with its lower end passing through the through hole and threaded into the threaded hole. The crown has a insertion groove in its lower center, which is fitted onto the abutment and bonded to it. A locating pin is vertically fixed in the center of the corresponding insertion groove of the crown. A locating hole is vertically formed between the screw and the threaded hole, capable of disrupting the external thread of the screw and the internal thread of the threaded hole. The head of the screw also has a vertical hole that communicates with the locating hole. The locating pin passes through the vertical hole and is inserted into the locating hole. Existing implant structures can achieve denture implantation, but the processes of tooth extraction, implant placement, and wound suturing often involve significant bleeding. If hemostasis, wound cleaning, and anti-inflammatory treatment are not performed promptly, bacterial growth at the surgical site can occur, leading to plaque formation and further peri-implantitis, significantly reducing the success rate of implant surgery. Simultaneously, medications administered during implant surgery only last for a few days or weeks, and postoperative medication is cumbersome, may not effectively reach the wound site, and can easily cause secondary trauma. With the increasing demand for dental implants and higher expectations for postoperative healing, traditional implant dentures can no longer meet patients' needs. There is an urgent need to develop a new type of implant denture that integrates slow-release drug delivery, anti-inflammatory properties, and hemostasis promotion. Summary of the Invention

[0003] To address the aforementioned problems, the present invention aims to provide a drug-loadable prosthesis for assisted treatment. By incorporating a drug-loadable linear structure within the external threaded structure of the implant and a frosted structure on the implant end face, the contact area between the implant outer wall and the implant socket is increased. This not only improves the stability and realism of the prosthesis but also increases the amount of drug absorbed, prolonging the duration of postoperative hemostatic, analgesic, or anti-inflammatory effects and shortening the postoperative alveolar bone healing time. In particular, by combining the drug storage tube and drug delivery tube inside the implant, it possesses multiple functions including sustained-release drug delivery, anti-inflammatory effects, and hemostasis promotion.

[0004] The technical solution adopted by the present invention to solve its technical problem is: a drug-assisted treatment denture, including an implant, an abutment, and an artificial crown located on the abutment; the abutment is connected to the implant through a threaded structure; the outer surface of the implant is provided with an external threaded structure; the implant is provided with a drug storage tube for temporarily storing drugs and a drug delivery tube for discharging drugs; the drug delivery tube is connected to the end of the drug storage tube.

[0005] In this invention, the abutment is conventionally selected according to the description of the invention, and it is sufficient to connect the implant and the artificial crown. Generally, a metal product is selected.

[0006] In this invention, the artificial crown is conventionally selected according to the description of the invention, and its shape is similar to the tooth structure. Specific tooth types include central incisors, lateral incisors, canines, and molars, etc., and porcelain material is generally selected.

[0007] In this invention, the implant is cylindrical with a diameter of 2-6 mm and a length of 5-17 mm. The specific specifications can be selected according to the type of missing tooth.

[0008] In this invention, the diameter of the drug storage tube is 1-3 mm and the length is 3-12 mm. The amount of drug stored can last for several weeks or months. At the same time, the relatively small diameter of the drug storage tube ensures the thickness of the implant wall, thereby ensuring the stability of the denture.

[0009] In this invention, the external thread structure contains a drug-loaded linear structure; the drug-loaded linear structure is a groove located between adjacent external thread structures; the direction of the groove is parallel to the direction of the external thread structure; the width of the groove is 0.2-0.5 mm, and the length is the same as that of the external thread structure; in dental implant surgery, it is necessary to use a scalpel to cut open the gums to expose the alveolar bone and grind an implant socket in the alveolar bone for implant placement, which inevitably causes trauma to the gums and alveolar bone. Before use, the implant is soaked in analgesic or angiogenesis-promoting drugs for several minutes. The drug-loaded linear structure not only allows the drug to directly reach the wound surface around the implant, making the drug take effect quickly, but also increases the implant surface area, increases the amount of drug absorbed, and prolongs the duration of hemostatic, analgesic, or anti-inflammatory effects; in addition, the linear drug-loaded structure allows the cells that have grown into it to maintain information and material exchange, making it less likely to cause an inflammatory response.

[0010] In this invention, the distal surface of the implant has a frosted structure. Like the drug-loaded linear structure, this frosted structure increases the contact area between the implant and bone tissue, thereby increasing the efficiency of integration and healing, and shortening the healing time. Furthermore, the increased contact area between the alveolar bone and the implant improves the stability of their integration. After healing, the implant, connected to the bone, can distribute the occlusal force more evenly to the alveolar bone. Preferably, a surface pore diameter of 150–400 μm for the frosted structure results in better integration.

[0011] In this invention, the threaded structure includes an internal thread on the upper inner wall of the drug reservoir and an external thread on the lower part of the abutment. The internal and external threads cooperate to connect the implant and the abutment, while ensuring that the medication does not leak from the upper part of the implant. This threaded connection method not only simplifies and facilitates the fixing process but also effectively ensures the stability of the prosthesis after implantation. This allows the implant user to smoothly transmit the biting force from the abutment through the implant to the alveolar bone when chewing food, resulting in a more realistic user experience. Furthermore, since the threaded connection structure is located at the upper part of the drug reservoir, ample storage space is created at the lower part of the reservoir.

[0012] In this invention, the number of drug delivery tubes is one or more; the number of drug delivery tubes can be set according to the actual required dosage per unit time.

[0013] In this invention, to prevent food impaction around the dental implant from causing bacterial growth and subsequently leading to periodontitis or peri-implantitis, a triangular prism protrusion extends upward from the center of the abutment, and a cavity matching the protrusion is formed by an inward indentation in the center of the artificial crown, so that there is a certain frictional resistance between the protrusion and the cavity during separation; the purpose of the prism design is to prevent the artificial crown from being displaced due to rotational force; the abutment and the artificial crown are connected by a fastening structure; the fastening structure consists of a convex ring on the outer peripheral wall of the protrusion and an annular groove on the inner sidewall of the cavity.

[0014] The beneficial effects of this invention compared to the prior art are as follows: The drug-loadable assisted treatment denture of this invention, by setting a drug-loadable linear structure in the external thread structure of the implant and a rough structure on the end face of the implant, increases the contact area between the outer wall of the implant and the implant socket. This not only increases the amount of drug adsorbed, but also prolongs the duration of the hemostatic, analgesic, or anti-inflammatory effects after surgery, shortens the healing time of the alveolar bone after surgery, and improves the stability and somatic realism of the denture.

[0015] In addition, by setting up drug storage tubes and delivery tubes in the implant, different types, concentrations and dosages of drug solutions can be added according to different needs, so that they can be slowly released to the area around the implant, especially to the bottom of the implant, which is difficult to administer drugs, so as to play a role in the auxiliary treatment of the wound surface around the implant.

[0016] Therefore, the drug-loadable adjuvant therapy denture of the present invention has multiple therapeutic functions such as sustained-release drug delivery, anti-inflammatory and hemostatic promotion, and has a simple and stable structure and is convenient to use. Attached Figure Description

[0017] Figure 1 This is an exploded schematic diagram of the drug-loadable adjuvant therapy denture of Example 1.

[0018] Figure 2 This is a schematic diagram of the implantation external thread structure in Example 1.

[0019] Figure 3 This is a schematic diagram of the implant structure in Example 2.

[0020] Among them, artificial crown 1, abutment 2, external thread 3, internal thread 4, implant 5, drug storage tube 6, external thread structure 7, drug delivery tube 8, frosted structure 9, implantation hole 10, and drug-loaded linear structure 11. Detailed Implementation

[0021] The technical solution of the present invention will be clearly and completely described below with reference to the accompanying drawings and preferred embodiments. The specific positional relationships (inner and outer, upper and lower) of the present invention are based on the actual positional relationships when the denture is implanted in the alveolar bone. Bone healing promoting drugs, analgesics, anti-inflammatory drugs, hemostatic agents, cleaning agents, etc., are all existing products; their specific selection and dosage should conform to dental and oral medication standards. The inventiveness of this invention lies in disclosing a novel denture structure. Example 1

[0022] like Figure 1 , Figure 2 As shown: A drug-assisted treatment denture includes an implant 5, an abutment 2, and an artificial crown 1 located on the abutment; the artificial crown is made of porcelain material and is fixedly connected to the abutment by an adhesive; the implant 5 is made of titanium alloy and has a cylindrical structure with a diameter of 4 mm and a length of 7 mm; the diameter, length, and material properties of the implant groove are not limited and can be changed according to actual use needs, such as a length of 9 mm or 11 mm, and a material of titanium or zirconium oxide, etc.

[0023] The implant body has an external thread structure 7 on its outer surface; the external thread structure 7 has a drug-loaded linear structure 11 with the same orientation as the external thread structure; specifically, the drug-loaded linear structure is a groove located between adjacent external thread structures; the orientation of the groove is parallel to the orientation of the external thread structure; the width of the groove is 0.2 mm, and its length is consistent with the length of the external thread structure; during dental implant surgery, the gums need to be cut open with a scalpel to expose the alveolar bone, and an implant socket 10 needs to be ground in the periodontal tissues such as the alveolar bone for implant placement. Therefore, trauma to the gums and alveolar bone is inevitable. Before use, the implant is soaked in analgesic or angiogenesis-promoting drugs for several minutes. The drug-loaded linear structure not only allows the drug to reach the wound surface around the implant, making the drug take effect quickly, but also increases the implant surface area, increases the amount of drug absorbed, and prolongs the duration of hemostatic, analgesic, or anti-inflammatory effects; in addition, the linear structure allows the cells that grow into it to maintain information and material exchange, making it less likely to cause an inflammatory response.

[0024] The implant contains a drug reservoir 6 for temporary medication storage. The reservoir has a bottom diameter of 2 mm and a length of 5 mm, with four 1 mm long delivery tubes 8 connected to its end. During implant surgery or subsequent treatment, medication can be placed in the reservoir and slowly discharged through the delivery tubes below, where it is absorbed by the periodontal tissues surrounding the implant, serving both a cleaning and slow-release medication function.

[0025] The abutment is connected to the implant via a threaded structure. This threaded structure includes an internal thread 4 on the upper inner wall of the drug reservoir and an external thread 3 on the lower part of the abutment. This serves to connect the implant and the abutment while preventing medication from leaking out from the upper part of the implant. The threaded connection not only simplifies and facilitates the fixing process but also effectively ensures the stability of the prosthesis after implantation. This allows the patient to smoothly transmit the biting force from the abutment through the implant to the alveolar bone when chewing, resulting in a more realistic user experience. Furthermore, the threaded connection on the upper part of the drug reservoir creates ample storage space in the lower part of the reservoir.

[0026] The method of using the drug-loadable assisted denture in this embodiment is as follows: First, inject one or more of the following drugs into the drug storage tube of the drug-loadable assisted denture: bone healing promoting drugs, analgesic drugs, and anti-inflammatory drugs. Then, soak the implant in one or more of the following drugs: hemostatic solution, anti-inflammatory solution, and cleaning solution for 5 to 15 minutes. Remove the implant and place it into the implant socket on the alveolar bone. Example 2

[0027] Based on Example 1, the difference in this example is as follows: Figure 3 As shown, the distal end face of the implant has a frosted structure 9. Like the drug-loaded linear structure, the frosted structure increases the contact area between the implant and bone tissue, thus increasing the efficiency of integration and healing, thereby shortening the healing time. Furthermore, the increased contact area between the alveolar bone and the implant improves the stability of their integration. After healing, the implant, connected to the bone, can distribute the biting force more evenly to the alveolar bone, resulting in a more realistic chewing sensation.

[0028] In this embodiment, the analgesic and anti-inflammatory effects of the drug-loaded adjuvant denture are more pronounced during use, and the indicators such as bone contact area and bone healing time are also superior to those of Embodiment 1. Example 3

[0029] The difference between this embodiment and Embodiment 1 is that, in order to prevent food impaction around the dental implant from causing bacterial growth and subsequently leading to periodontitis or peri-implantitis, a triangular prism protrusion is formed by extending upward from the center of the abutment, and a cavity matching the protrusion is formed by the inward indentation of the center of the artificial crown, so that there is a certain frictional resistance between the protrusion and the cavity during separation; the purpose of the prism design is to prevent the artificial crown from being displaced due to rotational force; the abutment and the artificial crown are connected by a fastening structure; the fastening structure consists of a convex ring on the outer peripheral wall of the protrusion and an annular groove on the inner side wall of the cavity of the artificial crown.

[0030] This invention relates to the orientation of a drug-supported therapeutic denture placed vertically with the implant below and the artificial crown above. In actual use, depending on the type of tooth loss, the novel drug-supported denture is used. Actual comparisons show that the healing degree is almost identical. The drug-supported therapeutic denture disclosed in this invention integrates with periodontal tissue in approximately 70% of the time required for traditional dentures. During treatment, various indicators such as denture stability, alveolar bone resorption, plaque content, incidence of peri-implantitis, and patient satisfaction are all superior to traditional dentures.

[0031] This invention presents a novel drug-loadable prosthesis with multiple therapeutic functions, including sustained-release administration, anti-inflammatory effects, and hemostasis promotion. The procedure is simple, and the linear drug-loaded structure facilitates both drug adsorption and the contact and healing between bone tissue and implants. It also reduces patient pain, increases patient satisfaction, and improves the success rate of prosthesis implantation. This invention is suitable for widespread application in dental clinics and hospital dentistry departments at all levels.

[0032] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A drug-loaded auxiliary treatment denture, comprising an implant, an abutment and an artificial crown on the abutment; the abutment is connected with the implant through a threaded structure; characterized in that: The implant outer surface is provided with external thread structure; the implant inner part is provided with medicine storage tube and medicine guide tube; the medicine guide tube is connected to the end of the medicine storage tube; also provided with medicine carrying linear structure; the medicine carrying linear structure is the groove between adjacent external thread structure; the groove direction is parallel to the external thread structure direction; the groove width is 0.2-0.5mm, the length is the same as the external thread structure; the end surface of the implant is provided with frosted structure. ​ 2. The drug-loadable adjuvant therapy denture according to claim 1, wherein: The medicine guide tube is one or more.

3. The drug-loadable adjuvant therapy denture of claim 1, wherein: The middle part of the abutment extends upward to form a prismatic boss; the middle part of the artificial crown is inwardly recessed to form a matching concave cavity; the abutment and the artificial crown are connected through the snap-fit structure; the snap-fit structure is the matching convex ring on the outer peripheral wall of the boss and the annular groove on the inner side wall of the concave cavity.

4. The method of treating a drug-loaded prosthetic dental appliance of claim 1, wherein: The processing of the medicine-carrying auxiliary treatment denture includes the following steps: first, injecting medicine into the medicine storage tube of the implant, then soaking the implant in the medicine solution, and finally taking out the implant.

5. The use of the medicine-carrying auxiliary treatment denture of claim 1 in the preparation of implant tooth.

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