CH-coated SHP099-NPs composite hydrogel as well as preparation method and application thereof

The CH@SHP099-NPs composite hydrogel enables precise intervention on the inflammatory microenvironment of the synovial membrane in osteoarthritis (OA), overcoming the limitations of existing drug delivery systems in OA treatment and achieving long-term local drug delivery and alleviating disease progression.

CN122272631APending Publication Date: 2026-06-26THE FIRST AFFILIATED HOSPITAL OF HENAN UNIV
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Patent Information

Application Number
CN202610616488.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-07
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Current OA treatments lack effective means to fundamentally intervene in synovial immune metabolism abnormalities and achieve precise and long-term local drug delivery to the joint. Traditional drug delivery systems are difficult to maintain effective drug concentrations within the joint cavity and may cause off-target effects.

Method used

A CH@SHP099-NPs composite hydrogel was developed. By embedding SHP099 nanoparticles into an injectable hydrogel composed of chondroitin sulfate and hyaluronic acid, and using Genipin crosslinking to form a stable network, a local long-term retention and controlled release of the drug was achieved. Combined with PLGA-PEG-cLABL nanocarriers, the drug was delivered to macrophages in a targeted manner.

Benefits of technology

This study achieved precise intervention in the inflammatory microenvironment of the synovium, significantly alleviated structural joint damage in OA mice, protected the cartilage matrix, and delayed disease progression, providing new insights into the pathogenesis of OA and treatment strategies.

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Abstract

The invention discloses CH-coated SHP099-NPs composite hydrogel as well as a preparation method and application thereof, and belongs to the technical field of biological medicines. Aiming at the technical problem that long-term, safe and accurate metabolic intervention of existing SHP2 is difficult to realize, a hydrogel system consisting of chondroitin sulfate and hyaluronic acid is constructed, SHP099 loaded nanoparticles can be retained in an articular cavity, and a long-acting synovial membrane drug library is formed, so that an SHP2-AMPK signal axis is continuously inhibited. The prepared CH-coated SHP099-NPs composite hydrogel can effectively reprogram the metabolism state of macrophages, reduce glycolysis flux, recover the immune metabolism steady state of a synovium and remarkably improve synovitis, cartilage cell activity and cartilage structure integrity in vivo, a mechanism-oriented local delivery metabolism intervention strategy is provided, and the application prospect is wide. And a new intervention treatment thought is expected to be provided for osteoarthritis treatment.
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