Antibacterial and bone growth promoting composite material and method of making and use thereof

Abstract

The application relates to the technical field of biomaterials, in particular to an antibacterial and bone growth promoting composite material and a preparation method and application thereof. An antibacterial and bone growth promoting composite material is provided, which comprises 80-99.5% of metal materials and 0.5-20% of auxiliary materials in terms of weight percentage, wherein the auxiliary materials are at least one selected from strontium-containing compounds, fluorine-containing compounds and zinc-containing compounds. The obtained composite material has strong antibacterial property and bone formation promoting effect, and has the advantages of good biocompatibility, corrosion resistance, metal luster and the like, and can be stably and long-term used as a medical metal material in the orthopedic and dental fields.

Description

Technical Field

[0001] This application belongs to the field of biomaterials technology, and in particular relates to an antibacterial and bone-growth-promoting composite material, its preparation method and application. Background Technology

[0002] Due to surgical trauma, severe dental caries causing tooth loss, and accidental bone defects, tooth damage significantly impacts human health and quality of life. With advancements in biomedical materials, dentistry, minimally invasive surgery, and advanced manufacturing, dental implant technology emerged in the 1950s. Metal-based biomaterials are now widely used in dentistry and orthopedics, playing a crucial role in repairing hard tissues and improving patients' quality of life. Metal materials are widely used in fracture and bone defect treatments. Currently, commonly used metal fixation devices in clinical practice include stainless steel, cobalt-chromium alloys, titanium and its alloys, tantalum, niobium, and biodegradable magnesium. Pure titanium and titanium alloy bone implants have gradually become commercialized, as they integrate with surrounding bone tissue. However, the surface of titanium and titanium alloy implants is bioactive, allowing for slow integration with surface bone rather than rapid bone growth, resulting in a longer implantation cycle and making immediate implantation difficult.

[0003] Tantalum, as a biomedical metal, possesses excellent fatigue resistance, corrosion resistance, and good biocompatibility with surrounding bone tissue. In 1940, tantalum wires were used as surgical sutures, and tantalum sheets as bone patches for skull repair and limb fixation. However, despite aseptic techniques and strict adherence to sterilization procedures throughout the surgery, a 4% infection rate still exists clinically. Once a surgical infection occurs and a bacterial film forms on the implanted material, it is difficult to completely eradicate the bacteria even with antibiotics, causing surgical pain and additional costs for patients, and in severe cases, endangering their lives. Therefore, materials with antibacterial properties can inhibit and kill microorganisms on and around the implanted material.

[0004] Currently, some of the hybrid materials provided are prepared by using antibacterial materials as coating materials. Although they can play a corresponding antibacterial role, the coating materials are easy to peel off, resulting in a short service life and making them unsuitable for widespread application. Summary of the Invention

[0005] The purpose of this application is to provide an antibacterial and bone-growth-promoting composite material, its preparation method and application, aiming to solve the problem that the coating materials containing antibacterial materials provided in the prior art are prone to peeling off and affecting their use.

[0006] To achieve the above-mentioned objectives, the technical solution adopted in this application is as follows:

[0007] In a first aspect, this application provides an antibacterial and bone-growth-promoting composite material, comprising the following components by weight percentage, based on 100% of the total weight of the composite material:

[0008] Metallic materials: 80%–99.5%;

[0009] Auxiliary materials: 0.5%–20%;

[0010] The auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds.

[0011] Secondly, this application provides a method for preparing an antibacterial and bone-growth-promoting composite material, comprising the following steps:

[0012] Provide metallic materials and auxiliary materials;

[0013] After mixing the metallic materials and auxiliary materials, the mixture is ball-milled to obtain intermediate material;

[0014] The intermediate material is subjected to discharge plasma sintering and then cooled to obtain a composite material that is antibacterial and promotes bone growth.

[0015] Thirdly, this application provides the application of antibacterial and bone-growth-promoting composite materials, or composite materials prepared by methods for preparing antibacterial and bone-growth-promoting composite materials, in the preparation of orthopedic medical metal materials or dental medical metal materials.

[0016] The first aspect of this application provides an antibacterial and bone-growth-promoting composite material, which is mainly composed of a metallic material and synergistically incorporates auxiliary materials. The auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds. The metallic material and at least one of the auxiliary materials (strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds) work synergistically to form the composite material. The resulting composite material has strong antibacterial and bone-growth-promoting effects, as well as good biocompatibility, corrosion resistance, and metallic luster. It can be stably and for a long time used as a medical metallic material in the fields of orthopedics and dentistry.

[0017] The second aspect of this application provides a method for preparing an antibacterial and bone-growth-promoting composite material. This method involves mixing the provided raw materials and then preparing the composite material using a spark plasma sintering process. The antibacterial and bone-growth-promoting composite material can be prepared in a single sintering step. The preparation process is simple, does not require large-scale equipment, and is conducive to large-scale preparation.

[0018] The application of the antibacterial and bone-growth-promoting composite material provided in the third aspect of this application, or the composite material prepared by the method of preparing the antibacterial and bone-growth-promoting composite material, in the preparation of orthopedic medical metal materials or dental medical metal materials, is due to the strong antibacterial and bone-growth-promoting effects of the obtained antibacterial and bone-growth-promoting composite material, as well as the advantages of good biocompatibility, corrosion resistance, and metallic luster. Therefore, it can be widely and stably applied in the preparation of orthopedic medical metal materials or dental medical metal materials. Attached Figure Description

[0019] To more clearly illustrate the technical solutions in the embodiments of this application, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0020] Figure 1 This is a scanned image analysis diagram of the composite material obtained in Example 1 of this application.

[0021] Figure 2 This is the energy dispersive spectroscopy (EDS) analysis diagram of the composite material obtained in Example 1 of this application.

[0022] Figure 3 This is a scanned image analysis diagram of the composite material obtained in Example 2 of this application.

[0023] Figure 4 This is a live cell staining analysis diagram of the composite material obtained in Example 3 of this application.

[0024] Figure 5 This is a live cell staining analysis diagram of the composite material obtained in Example 4 of this application.

[0025] Figure 6 This is a live cell staining analysis diagram of the composite material obtained in Example 5 of this application.

[0026] Figure 7 This is a live cell staining analysis diagram of the composite material obtained in Comparative Example 1 of this application. Detailed Implementation

[0027] To make the technical problems, technical solutions, and beneficial effects of this application clearer, the following detailed description is provided in conjunction with embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the scope of this application.

[0028] In this application, the term "and / or" describes the relationship between related objects, indicating that three relationships can exist. For example, A and / or B can represent: A existing alone, A and B existing simultaneously, or B existing alone. A and B can be singular or plural. The character " / " generally indicates that the preceding and following related objects have an "or" relationship.

[0029] In this application, "at least one" means one or more, and "more than one" means two or more. "At least one of the following" or similar expressions refer to any combination of these items, including any combination of single or multiple items. For example, "at least one of a, b, or c", or "at least one of a, b, and c", can both mean: a, b, c, ab (i.e., a and b), ac, bc, or abc, where a, b, and c can be single or multiple.

[0030] It should be understood that in the various embodiments of this application, the order of the above processes does not imply the order of execution. Some or all steps may be executed in parallel or sequentially. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of this application.

[0031] The terminology used in the embodiments of this application is for the purpose of describing particular embodiments only and is not intended to be limiting of this application. The singular forms "a" and "the" as used in the embodiments of this application and the appended claims are also intended to include the plural forms, unless the context clearly indicates otherwise.

[0032] The weights of the relevant components mentioned in the embodiments of this application can refer not only to the specific content of each component, but also to the proportional relationship between the weights of the components. Therefore, any scaling up or down of the content of the relevant components according to the embodiments of this application is within the scope disclosed in the embodiments of this application. Specifically, the mass in the embodiments of this application can be a well-known unit of mass in the chemical industry, such as μg, mg, g, or kg.

[0033] The terms "first" and "second" are used for descriptive purposes only, to distinguish objects, such as substances, from one another, and should not be construed as indicating or implying relative importance or implicitly specifying the number of technical features indicated. For example, without departing from the scope of the embodiments of this application, "first XX" may also be referred to as "second XX," and similarly, "second XX" may also be referred to as "first XX." Thus, features defined with "first" and "second" may explicitly or implicitly include one or more of that feature.

[0034] The first aspect of this application provides an antibacterial and bone-growth-promoting composite material, comprising the following components by weight percentage, based on 100% of the total weight of the composite material:

[0035] Metallic materials: 80%–99.5%;

[0036] Auxiliary materials: 0.5%–20%;

[0037] The auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds.

[0038] This application implements the first aspect of the antibacterial and bone-growth-promoting composite material, which is mainly composed of a metallic material and synergistically incorporates auxiliary materials. The auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds. The metallic material and at least one of the auxiliary materials (strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds) work synergistically to form the composite material. The resulting composite material has strong antibacterial and bone-growth-promoting effects, as well as good biocompatibility, corrosion resistance, and metallic luster. It can be stably and for a long time used as a medical metallic material in the fields of orthopedics and dentistry.

[0039] Specifically, the provided antibacterial and bone-growth-promoting composite material includes, by weight percentage, 80% to 99.5% metallic materials, based on 100% of the total weight of the composite material.

[0040] In some embodiments, the metallic material includes at least one of tantalum powder, niobium powder, and titanium powder. At least one of the selected tantalum powder, niobium powder, and titanium powder can serve as the main material for biomedical metals, all of which possess good fatigue resistance, corrosion resistance, and good biocompatibility with surrounding bone tissue.

[0041] In some specific embodiments, the weight percentage of the metallic material in the antibacterial and bone-growth-promoting composite material includes, but is not limited to, 80%, 82%, 85%, 87%, 89%, 90%, 92%, 95%, 97%, 99%, and 99.5%. The specific amount added is not limited to the listed values, and other unlisted values ​​within this range also apply.

[0042] Specifically, the provided antibacterial and bone-growth-promoting composite material includes, by weight 100%, auxiliary materials comprising 0.5% to 20% of the total composite material. These auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds. The metallic material and at least one of the auxiliary materials (strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds) synergistically form the composite material, resulting in a composite material with strong antibacterial and bone-growth-promoting effects. It also possesses good biocompatibility, corrosion resistance, and a metallic luster, enabling stable and long-term use as a medical metallic material in orthopedics and dentistry.

[0043] In some specific embodiments, in the antibacterial and bone-growth-promoting composite material, the weight percentage of the auxiliary material includes, but is not limited to, 0.5%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8%, 8.5%, 9%, 9.5%, 10%, 10.5%, 11%, 11.5%, 12%, 12.5%, 13%, 13.5%, 14%, 14.5%, 15%, 15.5%, 16%, 16.5%, 17%, 17.5%, 18%, 18.5%, 19%, 19.5%, and 20%. The specific amount added is not limited to the listed values; other unlisted values ​​within this range also apply.

[0044] In some embodiments, the excipient material is selected from SrF2 or ZnO. When SrF2 is selected, it exhibits good antibacterial activity and can stimulate bone formation. When ZnO is selected, it can cause cell membrane damage through electrostatic interactions, leading to proton leakage and the generation of reactive oxygen species, which damage organic biomolecules such as lipids, carbohydrates, nucleic acids, and proteins, thereby causing microbial death and achieving an antibacterial effect. Simultaneously, it promotes bone formation.

[0045] In some embodiments, the provided antibacterial and bone-growth-promoting composite material comprises, by weight percentage, the following components based on 100% of the total weight of the composite material:

[0046] Metal materials 80%,

[0047] Auxiliary materials 20%;

[0048] Furthermore, the metallic material is selected from tantalum powder, and the auxiliary material is selected from SrF2.

[0049] In some embodiments, the compressive strength of the composite material is 1–2 GPa and the Vickers hardness is 400–600 HV.

[0050] In some specific embodiments, the compressive strength of the composite material includes, but is not limited to, 1 GPa, 1.2 GPa, 1.4 GPa, 1.6 GPa, 1.8 GPa, and 2 GPa. The specific compressive strength is not limited to the listed values; other unlisted values ​​within this range also apply.

[0051] In some specific embodiments, the Vickers hardness of the composite material includes, but is not limited to, 400 HV, 450 HV, 500 HV, 550 HV, and 600 HV. The specific Vickers hardness is not limited to the listed values; other unlisted values ​​within this range also apply.

[0052] The second aspect of this application provides a method for preparing an antibacterial and bone-growth-promoting composite material, comprising the following steps:

[0053] S01. Provide metallic materials and auxiliary materials;

[0054] S02. After mixing the metal materials and auxiliary materials, the mixture is ball-milled to obtain intermediate material;

[0055] S03. The intermediate material is subjected to discharge plasma sintering and then cooled to obtain an antibacterial composite material that promotes bone growth.

[0056] The second aspect of this application provides a method for preparing an antibacterial and bone-growth-promoting composite material. This method involves mixing the provided raw materials and then preparing the composite material using a spark plasma sintering process. The antibacterial and bone-growth-promoting composite material can be prepared in a single sintering step. The preparation process is simple, does not require large-scale equipment, and is conducive to large-scale preparation.

[0057] In step S01, metal materials and auxiliary materials are provided; the amount and type of metal materials and auxiliary materials provided are as discussed above, and will not be repeated here for the sake of brevity.

[0058] In step S02, the metal material and auxiliary material are mixed and then ball-milled to obtain intermediate material.

[0059] In some embodiments, the step of mixing the metal material and the auxiliary material includes, but is not limited to, stirring, with the aim of mixing the metal material and the auxiliary material evenly.

[0060] Furthermore, the metal materials and auxiliary materials are mixed and then ball-milled.

[0061] In some embodiments, the ball milling process is performed under a protective atmosphere. In some specific embodiments, the protective atmosphere includes, but is not limited to, any one of helium, neon, argon, krypton, xenon, and radon protective atmospheres.

[0062] In some embodiments, the ball milling process takes 4 to 12 hours. If the ball milling time is too short, the metal materials and auxiliary materials cannot be mixed evenly; if the ball milling time is too long, the reaction efficiency will be affected.

[0063] In some specific embodiments, the ball milling time includes, but is not limited to, 4 hours, 5 hours, 6 hours, 7 hours, 8 hours, 9 hours, 10 hours, 11 hours, and 12 hours.

[0064] In some embodiments, the ball-to-material ratio is controlled at 5:1 during the ball milling process.

[0065] In step S03, the intermediate material is subjected to discharge plasma sintering and then cooled to obtain a composite material that is antibacterial and promotes bone growth.

[0066] Furthermore, the intermediate material is sintered using a discharge plasma sintering method. Discharge plasma sintering generates an electric arc between the sintered powders, thereby creating a high temperature between two adjacent powder particles. It is a non-melting powder metallurgy method.

[0067] In some embodiments, a vacuum process is performed before discharge plasma sintering. In some specific embodiments, the vacuum process may be performed to an absolute vacuum state.

[0068] In some embodiments, discharge plasma sintering includes sequentially heating, holding, and cooling under constant pressure.

[0069] In some embodiments, the constant pressure is 10 to 100 MPa; if the pressure is too low, the sintered product will have poor density, affecting the product performance; if the pressure is too high, it will be detrimental to the preparation.

[0070] In some specific embodiments, the constant pressure includes, but is not limited to, 10 MPa, 20 MPa, 30 MPa, 40 MPa, 50 MPa, 60 MPa, 70 MPa, 80 MPa, 90 MPa, and 100 MPa. The specific constant pressure is not limited to the listed values; other unlisted values ​​within this range also apply.

[0071] In some embodiments, the heating rate is 100-105℃ / min; the temperature is raised to a holding temperature of 1000℃-1400℃ and held for 2-15 minutes; then the temperature is lowered to room temperature at a cooling rate of 100-200℃ / min.

[0072] The holding temperature is controlled at 1000℃~1400℃, and the holding time is 2~15min. If the holding temperature is too low, it will affect the sintering effect. If the holding temperature is too high, it will affect the melting point of the auxiliary materials and will not be conducive to the preparation of composite materials. If the holding time is too short, it will cause incomplete sintering in some areas.

[0073] In some specific embodiments, the insulation temperature includes, but is not limited to, 1000℃, 1100℃, 1200℃, 1300℃, and 1400℃. The specific insulation temperature is not limited to the listed values; other unlisted values ​​within this range also apply.

[0074] In some specific embodiments, the heat preservation time includes, but is not limited to, 2 minutes, 5 minutes, 7 minutes, 9 minutes, 10 minutes, 12 minutes, and 15 minutes. The specific heat preservation time is not limited to the listed values; other unlisted values ​​within this range also apply.

[0075] In some specific embodiments, the heating rate includes, but is not limited to, 100°C / min, 101°C / min, 102°C / min, 103°C / min, 104°C / min, and 105°C / min. The specific heating rate is not limited to the listed values, and other unlisted values ​​within this range are also applicable.

[0076] In some specific embodiments, the cooling rate includes, but is not limited to, 100℃ / min, 110℃ / min, 120℃ / min, 130℃ / min, 140℃ / min, 150℃ / min, 160℃ / min, 170℃ / min, 180℃ / min, 190℃ / min, and 200℃ / min. The specific cooling rate is not limited to the listed values; other unlisted values ​​within this range also apply.

[0077] In some specific embodiments, the heating rate is 100℃ / min; the temperature is raised to a holding temperature of 1000℃ and held for 6 minutes; then the temperature is lowered to room temperature at a cooling rate of 200℃ / min.

[0078] The third aspect of this application provides the application of an antibacterial and bone-growth-promoting composite material, or a composite material prepared by a method for preparing an antibacterial and bone-growth-promoting composite material, in the preparation of orthopedic medical metal materials or dental medical metal materials.

[0079] The application of the antibacterial and bone-growth-promoting composite material provided in the third aspect of this application, or the composite material prepared by the method of preparing the antibacterial and bone-growth-promoting composite material, in the preparation of orthopedic medical metal materials or dental medical metal materials, since the obtained antibacterial and bone-growth-promoting composite material has strong antibacterial and bone-growth-promoting effects, and at the same time has good biocompatibility and corrosion resistance, and has metallic luster, etc., it can be widely and stably applied in the preparation of orthopedic medical metal materials or dental medical metal materials.

[0080] The following description is based on specific embodiments.

[0081] Example 1

[0082] An antibacterial and bone-growth-promoting composite material and its preparation method

[0083] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 95% Ta and 5% SrF2.

[0084] The preparation method includes the following steps:

[0085] The raw materials were mixed according to the formula provided in Example 1 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 4 hours.

[0086] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0087] The obtained Ta / SrF2 scan images are as follows Figure 1 As shown, the energy spectrum of the obtained Ta / SrF2 composite material is as follows: Figure 2 As shown.

[0088] Example 2

[0089] An antibacterial and bone-growth-promoting composite material and its preparation method

[0090] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 90% Ta and 10% SrF2.

[0091] The preparation method includes the following steps:

[0092] The raw materials were mixed according to the formula provided in Example 2 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 4 hours.

[0093] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0094] Example 3

[0095] An antibacterial and bone-growth-promoting composite material and its preparation method

[0096] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 80% Ta and 20% SrF2.

[0097] The preparation method includes the following steps:

[0098] The raw materials were mixed according to the formula provided in Example 3 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 4 hours.

[0099] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0100] Example 4

[0101] An antibacterial and bone-growth-promoting composite material and its preparation method

[0102] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 99% Ta and 1% SrF2.

[0103] The preparation method includes the following steps:

[0104] The raw materials were mixed according to the formula provided in Example 4 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 4 hours.

[0105] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0106] Example 5

[0107] An antibacterial and bone-growth-promoting composite material and its preparation method

[0108] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 90% Ta and 10% SrF2.

[0109] The preparation method includes the following steps:

[0110] The raw materials were mixed according to the formula provided in Example 5 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 8 hours.

[0111] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0112] Comparative Example 1

[0113] An antibacterial and bone-growth-promoting composite material and its preparation method

[0114] The antibacterial and bone-growth-promoting composite material is a Ta / SrF2 composite material, which comprises, by mass percentage: 60% Ta and 40% SrF2.

[0115] The preparation method includes the following steps:

[0116] The raw materials were mixed according to the formula provided in Comparative Example 1 and ball-milled to obtain intermediate material; wherein the ball milling was carried out under a protective atmosphere for 6 hours.

[0117] The intermediate material was subjected to SPS sintering and cooled to obtain Ta / SrF2 bulk material. The SPS sintering was controlled under vacuum conditions, with a pressure of 40 MPa, a heating rate of 100℃ / min, sintering at 1200℃ for 6 min, and a cooling rate of 200℃ / min.

[0118] Property Test

[0119] 1. The composite material obtained in Example 1 was subjected to scanning image analysis and energy dispersive spectroscopy analysis; the composite material obtained in Example 2 was subjected to scanning image analysis; and the composite materials obtained in Examples 3 to 5 and Comparative Example 1 were subjected to live cell staining analysis.

[0120] 2. The composite materials obtained in Examples 1-5 and Comparative Example 1, as well as pure tantalum, were analyzed for compressive strength, Vickers hardness, corrosion voltage, antibacterial properties, and alkaline phosphatase activity.

[0121] Results Analysis

[0122] 1. The composite material obtained in Example 1 was subjected to scanning image analysis as follows: Figure 1 As shown, the energy spectrum analysis diagram is as follows: Figure 2 As shown; the scanned image analysis diagram of the composite material obtained in Example 2 is shown below. Figure 3 As shown; the live cell staining analysis diagram of the composite material obtained in Example 3 is shown below. Figure 4 As shown; the live cell staining analysis diagram of the composite material obtained in Example 4 is shown below. Figure 5 As shown; the live cell staining analysis diagram of the composite material obtained in Example 5 is shown below. Figure 6 As shown; the live cell staining analysis diagram of the composite material obtained in Comparative Example 1 is shown below. Figure 7 As shown in the figure, the live cell staining analysis of the composite material obtained in Comparative Example 1 shows that it has obvious cytotoxicity and is not suitable for use.

[0123] 2. The compressive strength, Vickers hardness, corrosion voltage, antibacterial properties, and alkaline phosphatase activity of the composite materials obtained in Examples 1-5 and Comparative Example 1, as well as pure tantalum, were analyzed. The specific results are shown in Table 1. It can be seen that the compressive strength of the composite materials obtained in Examples 1-5 is 1.12-2 GPa; the Vickers hardness is 470-600 HV; the corrosion voltage is -0.265--0.14 V; the antibacterial property is 20%-100%; and the alkaline phosphatase activity (i.e., the reaction promoting osteogenic growth) is 3.8-5.3 U / gprot. In contrast, the pure tantalum material has 0% antibacterial property and cannot exert any antibacterial effect. The alkaline phosphatase activity (i.e., the reaction promoting osteogenic growth) of the composite material obtained in Comparative Example 1 is 0 U / gprot, and it cannot promote bone growth. Therefore, the composite materials provided in this application have both antibacterial properties and are beneficial to bone growth, and also possess certain compressive strength and Vickers hardness, making them suitable for wide application.

[0124] Table 1

[0125]

[0126] In summary, the antibacterial and bone-growth-promoting composite material provided in this application has a metallic material as the main component, with auxiliary materials added in synergy. The auxiliary materials are selected from at least one of strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds. The metallic material and at least one of the auxiliary materials (strontium-containing compounds, fluorine-containing compounds, and zinc-containing compounds) work synergistically to form the composite material. The resulting composite material has strong antibacterial and bone-growth-promoting effects, as well as good biocompatibility, corrosion resistance, and metallic luster. It can be stably and for a long time used as a medical metallic material in the fields of orthopedics and dentistry.

[0127] The above description is merely a preferred embodiment of this application and is not intended to limit this application. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this application should be included within the protection scope of this application.

Claims

1. A composite material that is antibacterial and promotes bone growth, characterized in that, Based on the total weight of the composite material as 100%, it includes the following components by weight percentage: 80% metallic materials; selected from tantalum powder; Auxiliary materials 20%; selected from SrF2; The composite material has a compressive strength of 2 GPa, a Vickers hardness of 600 HV, an antibacterial activity of 100%, and an alkaline phosphatase activity of 4.3 U / gprot. Furthermore, the preparation method of the antibacterial and bone-growth-promoting composite material includes the following steps: Provide metallic materials and auxiliary materials; The metal material and the auxiliary material are mixed and then ball-milled for 4 hours to obtain an intermediate material; The intermediate material is subjected to discharge plasma sintering and then cooled to obtain an antibacterial composite material that promotes bone growth. The discharge plasma sintering includes sequential heating, holding and cooling under constant pressure of 40 MPa, with a heating rate of 100 °C / min; heating to a holding temperature of 1200 °C for 6 min; and cooling to room temperature at a cooling rate of 200 °C / min.

2. The application of the antibacterial and bone-growth-promoting composite material according to claim 1 in the preparation of orthopedic medical metal materials or dental medical metal materials.

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