Injection system, syringe and gasket

Abstract

The present application provides an injection system, an injector, and a gasket. The injection system (1) includes: a gasket (100) having a plurality of engagement claws (122) including an inner surface (S1) dividing a hole (H) having a diameter expanded at an entrance and an outer surface (S2) inclined toward a direction away from a perpendicular line (P) passing through a center of the hole, and displaced between an expanded position and a contracted position; a plunger (110) inserted into the hole in engagement with the engagement claws; a barrel (91) into which the gasket is inserted, and abutting against the outer surface of the engagement claws of the gasket after the insertion; and an injection device (2) configured to advance the plunger, inject a liquid medicine into the barrel, and the gasket is formed with an annular groove (125) serving as a starting point of deformation of the engagement claws.

Description

[0001] This application is a divisional application of an application with international application No. PCT / JP2019 / 035546 (national application No. 201980059579.X) filed on September 10, 2019 (entered in the national phase on March 11, 2021), the title of which is "Injection system, syringe, and gasket", the content of which is incorporated herein by reference in its entirety. TECHNICAL FIELD

[0002] The present application relates to a syringe filled with a medical liquid, a gasket for the syringe, and an injection system incorporating the syringe. BACKGROUND

[0003] In the past, as a plunger and a gasket used for a syringe for injecting a medical liquid, for example, a piston having a portion capable of expanding and contracting and a syringe having a first inner diameter and a second inner diameter smaller than the first inner diameter are described in Patent Literature 1. The terminal portion of the plunger shaft is inserted into the space of the piston. Then, when the piston advances to the second inner diameter in the syringe, the portion capable of expanding and contracting contracts. Thereby, the protrusion of the piston (gasket) engages with the groove of the plunger shaft (plunger).

[0004] Prior art documents

[0005] Patent documents

[0006] Patent Literature 1: Japanese Patent Application Publication No. 2014-111185 SUMMARY

[0007] Problems to be solved by the invention

[0008] In Patent Literature 1, the protrusion of the gasket engages with the groove of the plunger, but the inner dimension of the groove is set to be larger than the outer dimension of the protrusion so that the protrusion easily intrudes into the groove. In addition, a gap can be generated between the protrusion intruding into the groove and the groove due to a manufacturing tolerance. Therefore, the plunger shakes with respect to the gasket, and can become a cause of generating a noise. Moreover, in a case where the central axis of the plunger is inclined with respect to the gasket, the pushing force is applied to the syringe in the inclined direction via the gasket. In this case, when a medical liquid is injected at a high pressure, the syringe can also be detached from the injection device.

[0009] Solution to the problem

[0010] To solve the above problems, an injection system according to one embodiment of the present application includes: a gasket having a plurality of engagement claws including an inner surface dividing a hole having a diameter expanded at an entrance and an outer surface inclined toward a direction away from a perpendicular line passing through a center of the hole, and the engagement claws are displaced between an expanded position and a contracted position; a plunger inserted into the hole in engagement with the engagement claws; a barrel into which the gasket is inserted, and the outer surface of the engagement claws of the gasket after the insertion abuts against the barrel; and an injection device configured to advance the plunger to inject a medical liquid in the barrel, and the gasket is formed with an annular groove serving as a starting point of deformation of the engagement claws.

[0011] Further, a syringe according to another embodiment of the present application includes: a gasket having a plurality of engagement claws including an inner surface dividing a hole having a diameter expanded at an entrance and an outer surface inclined toward a direction away from a perpendicular line passing through a center of the hole, and the engagement claws are displaced between an expanded position and a contracted position; and a barrel into which the gasket is inserted, and the outer surface of the engagement claws of the gasket after the insertion abuts against the barrel, and the gasket is formed with an annular groove serving as a starting point of deformation of the engagement claws.

[0012] Further, a gasket according to another embodiment of the present application includes a plurality of engagement claws including an inner surface dividing a hole having a diameter expanded at an entrance and an outer surface inclined toward a direction away from a perpendicular line passing through a center of the hole, and the engagement claws are displaced between an expanded position and a contracted position, and the gasket is formed with an annular groove serving as a starting point of deformation of the engagement claws.

[0013] Further features of the present application will become apparent from the following description of the embodiments with reference to the attached drawings. BRIEF DESCRIPTION OF DRAWINGS

[0014] Figure 1 is a schematic plan view of an injection head.

[0015] Figure 2 is a schematic exploded perspective view of a syringe according to a first embodiment of the present application.

[0016] Figure 3 is a schematic perspective view of a gasket.

[0017] Figure 4 is a schematic cross-sectional view illustrating a connection of a plunger and a gasket.

[0018] Figure 5 is a schematic cross-sectional view illustrating a connection of a plunger and a gasket.

[0019] Figure 6 is a schematic enlarged view of a boundary portion.

[0020] Figure 7 It is a schematic cross-sectional view illustrating the connection between the plunger and the sealing gasket.

[0021] Figure 8 It is a schematic cross-sectional view illustrating the connection between the plunger and the sealing gasket.

[0022] Figure 9 This is a schematic cross-sectional view of the syringe according to the second embodiment of the present invention.

[0023] Figure 10 This is a schematic rear view of the sealing gasket according to the third embodiment of the present invention.

[0024] Figure 11 This is a schematic rear view of the syringe involved in the variation example. Detailed Implementation

[0025] Hereinafter, exemplary embodiments for carrying out the present invention will be described in detail with reference to the accompanying drawings. However, the dimensions, materials, shapes, and relative positions of the constituent elements described in the following embodiments are arbitrary and can be varied depending on the structure of the device to which the present invention is applied or various conditions. Furthermore, unless otherwise specified, the scope of the present invention is not limited to the embodiments specifically described below. In addition, in the following description, the front side (“front”) corresponds to the tip of the syringe, and the opposite side corresponds to the rear side (“rear”).

[0026] [Example]

[0027] Figure 1 This is a schematic three-dimensional diagram of the injection system 1 used for injecting the drug solution. (See diagram below.) Figure 1 As shown, the injection system 1 is configured to advance the plunger 110, including the syringe 90 ( Figure 2 The injection system 1 includes an injection head 2 (injection device) for injecting liquid medicine into the syringe 90 within the syringe body 91. The injection system 1 also includes an adapter 8 for mounting the syringe 90 onto the injection head 2. The adapter 8 is mounted on a retainer of the injection head 2. The injection head 2 includes a pressing part 4 that presses against a sealing gasket 100 inserted into the syringe 90. Figure 2 ).

[0028] The pushing part 4 is controlled by a control unit (not shown) to advance and push the sealing gasket 100 inside the syringe 90 to deliver the liquid medicine inside the syringe 90. Additionally, the pushing part 4 includes a plunger 110 connected to a drive mechanism (not shown). Specifically, the control unit controls the motor inside the injection head 2 such that the plunger 110 advances when the motor rotates forward and retracts when the motor rotates in the reverse direction. Furthermore, the injection head 2 includes a reading unit 21 that reads data carriers such as RFID or barcodes mounted on the syringe 90 attached to the adapter 8.

[0029] In addition, the injection system 1 is connected to an imaging device (not shown) by wire or wirelessly. Moreover, various data are transmitted and received between the imaging device and the injection system 1 at the time of injection of the medical liquid and at the time of imaging. As such an imaging device, for example, there are an MRI (Magnetic Resonance Imaging) device, a CT (Computed Tomography) device, an angiography device, a PET (Positron Emission Tomography) device, a SPECT (Single Photon Emission Computed Tomography) device, a CT angiography device, an MR angiography device, an ultrasonic diagnostic device, and a vascular photography device.

[0030] Moreover, the injection system 1 includes a console (not shown) having a touch panel as a display portion that displays an injection condition of the medical liquid, and a control device (not shown) having a control portion and a power source. The console and the injection head 2 can be connected to each other by wire or wirelessly. Moreover, a remote operation device such as a hand switch can also be connected to the console by wire or wirelessly. The medical liquid injection can also be started or stopped by the remote operation device. In addition, the injection head 2 and the control device can be integrated with a caster support (not shown). Alternatively, the injection head 2 and the control device can be separately provided and mounted on the caster support.

[0031] The control device has data of an action mode (injection protocol) and data of the medical liquid stored in advance. In the case of injecting the medical liquid into a patient, an operator operates the touch panel of the console to input data of a body of the patient such as an injection speed, an injection amount, an injection time, a body weight, a body height, a body surface area, a heart rate, and a cardiac output, and data of a kind of the medical liquid. Then, the control device calculates an optimum injection condition based on the input data and the data stored in advance. Then, the control device determines an injection amount of the medical liquid to be injected into the patient and an injection protocol based on the calculated injection condition.

[0032] Moreover, the control device causes the touch panel of the console or the injection head display of the injection head 2 to display prescribed data or a graph at the time of determining the injection amount of the medical liquid and the injection protocol. Thereby, the operator can confirm the displayed data or the graph. The data of the action mode (injection protocol) and the data of the medical liquid can also be input from an external storage medium.

[0033] When injecting medication, the operator turns on the power to the injection head 2 and mounts the syringe 90 onto it. The operator then presses the injection button displayed on the touch panel. Alternatively, if the injection head 2 has an operation panel, the operator can also press the injection button on that panel. Furthermore, the operator can press the manual switch button to begin injection. Alternatively, the operator can turn on the power to the injection head 2 after mounting the syringe 90.

[0034] When the injection button is pressed, the control unit sends a forward rotation signal to the motor as a drive voltage. Based on this forward rotation signal, the motor shaft rotates forward, and the pusher 4 (plunger 110) advances. Then, after injection is completed and the syringe 90 is removed, the control unit sends a reverse rotation signal to the motor as a drive voltage to retract the plunger 110. Based on this reverse rotation signal, the motor shaft rotates in the opposite direction, and the plunger 110 retracts.

[0035] The pressing unit 4 has a drive mechanism (not shown). This drive mechanism includes a transmission mechanism connected to the motor shaft, a ball screw shaft connected to the transmission mechanism, a ball screw nut mounted on the ball screw shaft, and an actuator connected to the ball screw nut. The transmission mechanism also has a pinion gear connected to the motor shaft and a helical gear connected to the ball screw shaft. Furthermore, the transmission mechanism transmits rotation from the motor to the ball screw shaft. Therefore, the rotation of the motor shaft is transmitted to the ball screw shaft via the pinion gear and the helical gear. As a result, the ball screw shaft rotates with the transmitted rotation. Then, the ball screw nut slides in the forward or backward direction along with the rotation of the ball screw shaft. With the sliding of the ball screw nut, the plunger 110 of the pressing unit 4 moves forward or backward.

[0036] [First Implementation]

[0037] Figure 2 This is a schematic exploded perspective view of the syringe 90 according to the first embodiment, showing the syringe 90 as viewed from the front upper side. Figure 2 As shown, the syringe 90 has a sealing gasket 100 that can slide within a barrel 91. The barrel 91 is into which the sealing gasket 100 is inserted, and with respect to the outer surface S2 of the inserted sealing gasket 100. Figure 4 The cylinder 91 has a flange 92 that is mounted in a groove for the adapter 8. Furthermore, the sealing gasket 100 has a suction element 120, an O-ring 130, and a sealing member 140.

[0038] The suction member 120 has a substantially disc-shaped insertion portion 121 and a plurality of engagement claws 122 which are divided. A plurality of ribs which cross each other are formed in the insertion portion 121. Further, an annular groove 125 is formed between the insertion portion 121 and the engagement claws 122. The sealing member 140 has annular protrusions formed on the outer surface thereof. Further, the sealing member 140 seals the cylinder 91 by abutting the annular protrusions against the inner surface of the cylinder 91. Further, in the sealing member 140, a space in which the insertion portion 121 is accommodated is formed, and the rear end portion of the sealing member 140 protrudes toward the space. Further, the engagement claws 122 have protrusions 124 which engage with engagement grooves 112 formed in the front end portion 111 of the plunger 110. Figure 2 However, the number of the annular protrusions is not limited to three. Two, one, or four or more annular protrusions can be formed. Further, the sealing member 140 has a space in which the insertion portion 121 is accommodated, and the rear end portion of the sealing member 140 protrudes toward the space. Further, the engagement claws 122 have protrusions 124 which engage with engagement grooves 112 formed in the front end portion 111 of the plunger 110. Figure 3

[0039] In assembling the seal pad 100, first, the O-ring 130 is inserted from the insertion portion 121 side of the suction member 120, and the O-ring 130 is fitted in the groove 123 formed in the engagement claw 122. Next, the insertion portion 121 is inserted into the space in the sealing member 140, and the sealing member 140 is fitted to the suction member 120. At this time, the rear end portion of the sealing member 140 enters the annular groove formed at the rear of the insertion portion 121. Thus, the sealing member 140 is fixed with respect to the suction member 120. The fitted O-ring 130 restricts the expansion of the engagement claw 122. Therefore, the gap between the adjacent engagement claws 122 can be made uniform, and the interval between the protrusions 124 of the engagement claws 122 can be made constant.

[0040] In this way, the seal pad 100 is assembled. The suction member 120 is made of, for example, an elastic resin such as POM (polyoxymethylene resin), and can be manufactured by molding. Further, the sealing member 140 is made of, for example, butyl rubber, and can be manufactured by molding. Further, the plunger 110 is made of, for example, stainless steel or aluminum, and can be manufactured by welding the substantially cylindrical front end portion 111 which is a solid to a hollow pipe. Alternatively, the plunger 110 can be manufactured by screwing the solid front end portion 111 to the hollow pipe. Alternatively, the front end portion 111 can be manufactured using a material other than stainless steel or aluminum, and a material having a higher hardness than the seal pad 100.

[0041] In the state in which the engagement claws 122 of the seal pad 100 and the front end portion 111 of the plunger 110 are connected, when the motor is rotated in the forward direction, the pusher 4 presses the plunger 110 in the advancing direction. Then, when the plunger 110 and the seal pad 100 advance, the drug solution in the cylinder 91 is pushed out through the tip end portion 93. As a result, the drug solution is injected into the body of the patient through the extension hose or the like connected to the tip end portion 93. After the drug solution is injected, when the motor is rotated in the reverse direction, the pusher 4 pulls the plunger 110 in the retreating direction, and the seal pad 100 retreats.​

[0042] As Figure 2 shown, the corner portion connected to the end surface of the front end portion 111 is chamfered. Thereby, the corner portion is prevented from contacting the protrusion 124 when the plunger 110 is inserted. Further, the corner portion of the engagement groove 112 of the front end portion 111 is chamfered, and the corner portion is rounded. Thereby, when the protrusion 124 is engaged with or disengaged from the engagement groove 112, the protrusion 124 is prevented from being ground.

[0043] Figure 3 is a schematic perspective view of the gasket 100 viewed from the rear, and the O-ring 130 is omitted for convenience of explanation. As Figure 3 shown, the suction member 120 includes a plurality of engagement claws 122 having a substantially fan-shaped cross-sectional shape. The number of the plurality of engagement claws 122 is two or more, and is not limited to six. Further, gaps are formed between the adjacent engagement claws 122, and each of the engagement claws 122 is displaced so that the adjacent engagement claws 122 approach each other when the gasket 100 is inserted into the cylinder 91.

[0044] Each of the engagement claws 122 includes a groove 123 in which the O-ring 130 is fitted, and a protrusion 124 which is engaged with the engagement groove 112 of the plunger 110. The top end of the protrusion 124 is rounded so as to be easily inserted into the engagement groove 112 of the plunger 110. Further, in Figure 3 , only the groove 123 and the protrusion 124 of one of the engagement claws 122 are denoted by reference numerals. However, the grooves 123 and the protrusions 124 are provided in all of the six engagement claws 122. The engagement claws 122 are formed to have the same size, and the gaps between the engagement claws 122 have the same length. Thereby, when the engagement claws 122 are displaced, the positions of the engagement claws 122 relative to the plunger 110 are prevented from being changed. That is, as the gasket 100 is inserted, each of the engagement claws 122 is displaced by the same distance.

[0045] In the suction member 120, an annular groove 125 is formed between the insertion portion 121 and the engagement claws 122. In the portion in which the annular groove 125 is formed, the engagement claws 122 are connected to the insertion portion 121. In order to easily displace (deform) the engagement claws 122, the portion in which the annular groove 125 is formed is formed to have a thin wall compared to the portion in which the protrusions 124 are formed. Further, a hole H Figure 4 in which the protrusions 124 are surrounded is formed in the suction member 120, and the plunger 110 is inserted into the hole H in such a manner that the protrusions 124 are engaged with the engagement claws 122.

[0046] [Connection of the plunger 110 and the gasket 100]

[0047] The connection of the plunger 110 and the gasket 100 will be described with reference to Figures 4 to 8 . Figure 4This is a schematic cross-sectional view of a syringe 90 with the plunger 110 inserted before the hole H of the suction member 120. Figure 5 This is a schematic cross-sectional view of a syringe 90 with the plunger 110 inserted into the hole H of the suction member 120. Figure 6 yes Figure 5 A rough enlarged view of the part enclosed by the circle. Figure 7 This is a schematic cross-sectional view of a syringe 90 in which the plunger 110 is connected to the sealing gasket 100. Figure 8 This is a schematic cross-sectional view of the syringe 90 with the plunger 110 advancing the sealing gasket 100. Additionally, Figures 4 to 8 A cross section is shown that passes through the central axis of the cylinder 91 and along its length.

[0048] like Figure 4 As shown, the sealing gasket 100 has an enlarged inlet hole H. That is, in the hole H, the inlet for inserting the plunger 110 has a longer inner diameter compared to the bottom for pressing the end face of the plunger 110. Additionally, the sealing gasket 100 has a longer inner diameter in the enlarged position ( Figure 5 ) and the position of contraction ( Figure 7 The engaging claw 122 is a type of engagement claw that allows displacement between the holes. The engaging claw 122 includes: an inner surface S1 having a first inner surface 126 and a second inner surface 127 that divide the hole H; and an outer surface S2 that slopes away from a vertical line P passing through the center of the hole H (bottom). The first inner surface 126 extends annularly from the end face of the front end 111 of the feed plunger 110 of the hole H of the suction member 120, abutting the bottom of the suction member. Furthermore, the first inner surface 126 extends parallel to the vertical line P. The second inner surface 127 extends annularly from the first inner surface 126 to the protrusion 124. Furthermore, the second inner surface 127 slopes relative to the first inner surface 126 towards the inlet of the hole H, away from the vertical line P.

[0049] The outer surface S2 of the engaging claw 122 is inclined away from the vertical line P extending along the extension direction of the hole H as it approaches the inlet of the hole H. Therefore, the length of the line segment that intersects the vertical line P and connects the outer edges of the multiple engaging claws 122 is longer than the length of the inner diameter of the cylinder 91. That is, the outer edge of the engaging claw 122 is located outside the inner surface of the cylinder 91. In addition, the engaging claw 122 has a protrusion 124 protruding toward the vertical line P. Moreover, the plunger 110 has an annular engaging groove 112 for engaging the protrusion 124. However, if the protrusion 124 of the engaging claw 122 is not arranged in an annular shape when it is displaced to the contracted position, the engaging groove 112 may also be formed at the position corresponding to the protrusion 124.

[0050] The outer surface of the portion of the front end 111 of the plunger 110 near the end face of the engagement groove 112 is also slightly inclined relative to the central axis R of the plunger 110. The inclination angle of this outer surface relative to the central axis R (for example, 1 to 5 degrees) is set smaller than the inclination angle of the second inner surface 127 relative to the vertical line P (for example, 4 to 10 degrees). Because the outer surface of the front end 111 is inclined, the front end 111 can be guided into the hole H in such a way that the central axis R is aligned with the vertical line P when the front end 111 is inserted.

[0051] like Figure 5 As shown, when the plunger 110 is inserted into the hole H, the end face of the front end 111 abuts against the bottom of the hole H. At this time, the engaging claw 122 is in the expanded position, and the outer surface of the front end 111 abuts against the boundary portion B between the first inner surface 126 and the second inner surface 127 of the engaging claw 122. Figure 6 That is, the internal dimensions of the hole H in the suction member 120 are set such that the boundary portion B abuts against the outer surface of the front end portion 111. Hereinafter, refer to... Figure 6 Explain the boundary part B.

[0052] like Figure 6 As shown, an annular groove 125 is formed at the boundary portion B between the first inner surface 126 and the second inner surface 127 of the sealing gasket 100. This annular groove 125 serves as the starting point for the deformation of the engaging claw 122. The annular groove 125 has a generally semi-circular cross-section. Moreover, the boundary portion B is positioned corresponding to the center of the bottom of the annular groove 125. That is, the center of the bottom of the annular groove 125 and the boundary portion B are located in the same cross-section orthogonal to the length direction. As a result, the inner surface S1 of the engaging claw 122 is inclined with the boundary portion B as the boundary. Therefore, when the front end portion 111 is inserted, a gap is generated between the outer surface of the front end portion 111 and the second inner surface 127. In addition, since the outer surface of the front end portion 111 is also slightly inclined, a gap is also generated between the outer surface and the first inner surface 126. Furthermore, the annular groove 125 may also have a generally trapezoidal or generally triangular cross-sectional shape that narrows inward.

[0053] When the plunger 110 presses against the sealing gasket 100, the sealing gasket 100 advances within the cylinder 91. As the sealing gasket 100 advances, the outer surface S2 of the engaging claw 122... Figure 4 The cylinder tilts, causing the outer surface S2 of the engaging claw 122 to abut against the inner surface of the cylinder 91. Then, as it advances, under the reaction force from the inner surface of the cylinder 91, the engaging claw 122 displaces toward the vertical line P of the suction member 120. At this time, the engaging claw 122 deforms starting from the center of the bottom of the annular groove 125. Therefore, the boundary portion B is pressed tightly against the front end portion 111.

[0054] That is, the boundary portion B is displaced toward the perpendicular line P of the suction member 120. Thereby, even if the front end portion 111 is inserted in the hole H at a position offset with respect to the perpendicular line P, the front end portion 111 is displaced in a manner that the position of the central axis R of the front end portion 111 is aligned with the perpendicular line P. That is, the front end portion 111 is pressed by the boundary portion B and is displaced toward the center of the hole H. Therefore, it is possible to suppress the inclination of the central axis R with respect to the gasket 100. Also, even if a gap is generated between the front end portion 111 and the hole H of the suction member 120 due to a manufacturing tolerance or the like, it is possible to hold the front end portion 111 by the boundary portion B. Thereby, it is possible to suppress the wobble of the plunger 110 with respect to the gasket 100.

[0055] As shown in FIG. 6, when the gasket 100 is inserted in the barrel 91, the engagement claw 122 is contracted by the reaction force from the inner surface of the barrel 91. Then, the protrusion 124 of the engagement claw 122 at the contracted position intrudes in the engagement groove 112, and the protrusion 124 is engaged with the engagement groove 112. Thereby, the gasket 100 is linked with the plunger 110. In addition, the annular groove 125 is deformed in an expanded manner in conjunction with the displacement of the engagement claw 122. Then, as shown in FIG. 7, when the gasket 100 advances in the barrel 91, the sealing member 140 pushes the medical liquid in the barrel 91. Thereby, the medical liquid is pushed out from the top end portion 93 and is injected into the body of the patient via the extension hose or the like. Figure 7 Figure 8 As shown in FIG. 6, when the gasket 100 is inserted in the barrel 91, the engagement claw 122 is contracted by the reaction force from the inner surface of the barrel 91. Then, the protrusion 124 of the engagement claw 122 at the contracted position intrudes in the engagement groove 112, and the protrusion 124 is engaged with the engagement groove 112. Thereby, the gasket 100 is linked with the plunger 110. In addition, the annular groove 125 is deformed in an expanded manner in conjunction with the displacement of the engagement claw 122. Then, as shown in FIG. 7, when the gasket 100 advances in the barrel 91, the sealing member 140 pushes the medical liquid in the barrel 91. Thereby, the medical liquid is pushed out from the top end portion 93 and is injected into the body of the patient via the extension hose or the like.

[0056] After the medical liquid is injected, the plunger 110 is retracted, and the gasket 100 linked with the plunger 110 is also retracted. Then, when the plunger 110 and the gasket 100 are retracted to the position shown in FIG. 8, the restriction by the inner surface of the barrel 91 is released. Therefore, the engagement claw 122 is expanded outward, and the protrusion 124 of the displaced engagement claw 122 is disengaged from the engagement groove 112. Thereby, the protrusion 124 is disengaged from the engagement groove 112. That is, when the plunger 110 and the gasket 100 are retracted until the engagement claw 122 is displaced to the expanded position, the protrusion 124 is disengaged from the engagement groove 112. In addition, the annular groove 125 is narrowed in a manner that it returns to the original shape in conjunction with the displacement of the engagement claw 122. When the plunger 110 is further retracted, the gasket 100 is stopped at the position shown in FIG. 9 by the frictional force between the sealing member 140 and the barrel 91. As a result, the plunger 110 is disengaged from the gasket 100 and is retracted to the pre-insertion position shown in FIG. 10. Figure 5 Figure 5 Figure 4

[0057] ​​​​According to the plunger 110 and the gasket 100 according to the first embodiment, the engagement claws 122 are deformed from the center of the bottom of the annular groove 125. Therefore, the plurality of engagement claws 122 are displaced equally toward the perpendicular line P of the suction member 120. In addition, the boundary portion B holds the front end portion 111. Therefore, the position of the center axis R of the front end portion 111 of the plunger 110 is aligned with the perpendicular line P. Thus, when the plunger 110 is detached from the gasket 100, it is possible to suppress the front end portion 111 from being positioned at a position deviated from the perpendicular line P. Therefore, it is possible to prevent the engagement groove 112 of the front end portion 111 from being hooked on the protrusion 124.

[0058] In addition, according to the plunger 110 and the gasket 100 according to the first embodiment, when the gasket 100 and the plunger 110 are connected, it is possible to suppress the plunger 110 from wobbling with respect to the gasket 100. Moreover, since the gasket 100 and the plunger 110 are directly connected, it is possible to shorten the distance between the syringe 90 and the push portion 4. Therefore, it is possible to reduce the size of the injection head 2 in the injection system 1.

[0059] Further, instead of the protrusion 124 and the engagement groove 112, it is also possible to form an engagement groove in the engagement claws 122 of the gasket 100 and an annular protrusion in the front end portion 111 of the plunger 110. In addition, in a case where the engagement claws 122 can be manufactured with high precision, it is possible to omit the O-ring 130.

[0060] [Second Embodiment]

[0061] In the first embodiment, the engagement claws 122 of the gasket 100 before insertion protrude outward from the syringe 90. In the second embodiment, the barrel 291 of the syringe 290 has a skirt portion 295 that covers the engagement claws 222. Hereinafter, the second embodiment will be described with reference to Figure 9 The second embodiment will be described, but in the description of the second embodiment, only the points different from the first embodiment will be described, the same reference numerals will be attached to the structural elements already described in the first embodiment, and the description thereof will be omitted. Unless otherwise specifically described, the structural elements to which the same reference numerals are attached have substantially the same action and function, and have substantially the same effect.

[0062] Figure 9 is a schematic cross-sectional view of the syringe 290 before the plunger 110 is inserted into the hole H of the suction member 220. This Figure 9 A cross section passing through the center axis of the syringe 290 and in the length direction is shown. Further, since the structure of the plunger 110 is the same as that of the first embodiment, the illustration thereof will be omitted.

[0063] As Figure 9As shown, a skirt portion 295 is formed on a portion of the barrel 291 of the syringe 290 that is located rearward of the flange 292. The inner surface of the skirt portion 295 is inclined along the outer surface S2 of the engagement claw 222 in such a manner that the engagement claw 222 is located in the expanded position. Thus, the inner dimension of the skirt portion 295 is set to coincide with the outer dimension of the engagement claw 222 in the expanded state. That is, the skirt portion 295 has a shape that narrows toward the tip portion 293. As a result, the engagement claw 222 of the gasket 200 that is inserted into the inside of the skirt portion 295 does not displace to the contracted position. Or, even in the case where the engagement claw 222 slightly displaces, the interval between the opposing protrusions 224 is maintained in a state that allows the plunger 110 to be inserted. Thus, since the skirt portion 295 covers the engagement claw 222, the attachment of foreign matter to the engagement claw 222 can be suppressed.

[0064] The gasket 200 of the second embodiment has, like the first embodiment, an inner surface S1 that includes a first inner surface 226 and a second inner surface 227 that divide the hole H whose entrance is expanded, and an annular groove 225 that is formed at a position corresponding to the boundary portion B between the first inner surface 226 and the second inner surface 227 in such a manner as to become a starting point of deformation. In addition, the engagement claw 222 of the suction member 220 of the gasket 200 is not formed with the groove 123, nor is the O-ring 130 installed. Further, instead of the O-ring 130, the skirt portion 295 is used to restrict the engagement claw 222 from expanding. Thus, the gaps between the adjacent engagement claws 222 can be equalized, and the O-ring 130 can be omitted.

[0065] After the tip portion 111 of the plunger 110 is inserted, when the plunger 110 presses the gasket 200 by the tip portion 111, the gasket 200 advances within the barrel 291. When the gasket 200 advances, the outer surface of the engagement claw 222 passes through the skirt portion 295 and comes into abutment with the inner surface of the barrel 291. Then, as it advances, the engagement claw 222 displaces toward the center of the hole H of the suction member 220 under the reaction force from the inner surface of the barrel 291. At this time, the engagement claw 222 deforms with the center of the bottom of the annular groove 225 as a starting point.

[0066] Moreover, the boundary portion B between the first inner surface 226 and the second inner surface 227 is pressed against the front end portion 111. When the seal 200 is further inserted into the barrel 291, the engagement claws 222 are contracted by a reaction force from the inner surface of the barrel 291. Then, the protrusions 224 of the engagement claws 222 displaced to the contracted position intrude into the engagement grooves 112 of the plunger 110, and the protrusions 224 are engaged with the engagement grooves 112. Thus, the seal 200 is coupled to the plunger 110. Then, when the seal 200 advances in the barrel 291, the seal member 240 pushes the medical liquid in the barrel 291. Thus, the medical liquid is pushed out from the tip end portion 293 and injected into the body of the patient through the extension hose or the like.

[0067] After the medical liquid is injected, the plunger 110 is retracted, and the seal 200 coupled to the plunger 110 is also retracted. Then, the plunger 110 and the seal 200 are retracted to a position where the restriction by the inner surface of the barrel 291 is released. Thus, the engagement claws 222 are expanded outward, and the protrusions 224 are disengaged from the engagement grooves 112. As a result, the protrusions 224 are disengaged from the engagement grooves 112. When the plunger 110 is further retracted, the plunger 110 is disengaged from the seal 200.

[0068] According to the plunger 110 and the seal 200 related to the second embodiment, the engagement claws 222 are also deformed with the center of the bottom of the annular groove 225 as a starting point. Therefore, the plurality of engagement claws 222 are equally displaced toward the perpendicular line P of the suction member 220. In addition, when the seal 200 and the plunger 110 are coupled, the plunger 110 can be inhibited from wobbling with respect to the seal 200. Moreover, since the seal 200 and the plunger 110 are directly coupled, the distance between the syringe 290 and the push portion 4 can be shortened. Therefore, the size of the injection head 2 in the injection system 1 can be reduced. Moreover, according to the seal 200 related to the second embodiment, the attachment of foreign matter to the engagement claws 222 can also be inhibited.

[0069] Furthermore, the seal 100 of the first embodiment can also be installed in the barrel 291 of the second embodiment.

[0070] [Third Embodiment]

[0071] In the third embodiment, the engagement claws 322 of the seal 300 include the convex portions 328 and the concave portions 329. Hereinafter, the third embodiment will be described with reference to Figure 10 The third embodiment will be described, but in the description of the third embodiment, only the points different from the first embodiment will be described, the same reference numerals will be attached to the structural elements already described in the first embodiment, and the description thereof will be omitted. Unless otherwise specifically described, the structural elements to which the same reference numerals are attached have substantially the same action and function, and the effects thereof are also substantially the same.

[0072] The protrusion 328 of the engagement claw 322 has a shape that coincides with a quarter of a sphere, and the rear end surface of the suction piece 320 of the seal gasket 300 is formed flush with the engagement claw 322. Therefore, the protrusion 328 has a substantially semicircular shape when viewed from the rear side of the suction piece 320. Also, the protrusion 328 protrudes toward an adjacent engagement claw 322. In addition, the engagement claw 322 has a recess 329 that receives the protrusion 328 of the other adjacent engagement claw 322. The recess 329 has a shape that is complementary to the protrusion 328, and is formed at a position opposite the protrusion 328 of the other adjacent engagement claw 322. The recess 329 also has a substantially semicircular shape when viewed from the rear side of the suction piece 320, and the outer dimension of the protrusion 328 and the inner dimension of the recess 329 are set to coincide.

[0073] After the front end portion 111 of the plunger 110 is inserted, when the plunger 110 presses the seal gasket 300 by the front end portion 111, the seal gasket 300 advances inside the barrel 91. As the seal gasket 300 advances, the engagement claw 322 is displaced toward the center of the hole H of the suction piece 320 under the reaction force from the inner surface of the barrel 91. At this time, the engagement claw 322 is deformed from the center of the bottom of the annular groove 125. Further, as the seal gasket 300 is inserted into the barrel 91, the engagement claw 322 is contracted by the reaction force from the inner surface of the barrel 91.

[0074] Meanwhile, the adjacent engagement claws 322 are displaced toward each other. Therefore, the protrusion 328 is received by and engaged with the recess 329. With the engagement of both, the distance between the perpendicular line P of the hole H and the plurality of engagement claws 322 is fixed, and the inserted plunger 110 can be inhibited from being displaced inside the hole H. Then, as the seal gasket 300 further advances inside the barrel 91, the seal member 140 pushes the medical liquid inside the barrel 91. Thereby, the medical liquid is pushed out from the top end portion 93 and injected into the body of the patient via the extension hose or the like.

[0075] After the medical liquid is injected, the plunger 110 is retracted, and the seal gasket 300 coupled to the plunger 110 is also retracted. Then, the plunger 110 and the seal gasket 300 are retracted to a position where the restriction by the inner surface of the barrel 91 is released. Thereby, the engagement claw 322 expands outward, and the protrusion 124 is disengaged from the engagement groove 112. As a result, the protrusion 124 is disengaged from the engagement groove 112. When the plunger 110 is further retracted, the plunger 110 is disengaged from the seal gasket 300.

[0076] According to the plunger 110 and the gasket 300 according to the third embodiment, the plunger 110 can be prevented from wobbling with respect to the gasket 300 when the gasket 300 and the plunger 110 are coupled. Further, since the gasket 300 and the plunger 110 are directly coupled, the distance between the syringe 90 and the pushing portion 4 can be shortened. Therefore, the size of the injection head 2 in the injection system 1 can be reduced. Further, the distance between the perpendicular line P of the hole H and the plurality of engagement claws 322 can be constant.

[0077] Further, the protrusion 328 can have other shapes. For example, the protrusion 328 can have a shape identical to a triangular prism or a cylinder divided into two along the length direction. In this case, the protrusion 328 extends along the perpendicular line P, and the recess 329 has a shape complementary to the protrusion 328.

[0078] The present application has been described above with reference to each embodiment, but the present application is not limited to the above-described embodiments. The application altered within the scope of the present application and the application equivalent to the present application are also included in the present application. Further, each embodiment and the modified example described above can be appropriately combined without departing from the scope of the present application.

[0079] For example, the engagement claws 122, 222, 322 can be formed with notches or holes. Thus, the engagement claws 122, 222, 322 are easily displaced since the portions formed with the notches or holes are deformed. Further, the inner surface S1 of the gasket can not be divided into two surfaces. For example, the inner surface S1 can be configured as a continuous inclined surface or a curved surface. Further, the above-described gaskets 100, 200, 300 have an outer shape in which the cross section orthogonal to the perpendicular line P is substantially circular. However, the above-described gaskets 100, 200, 300 can have an outer shape in which the cross section orthogonal to the perpendicular line P is substantially elliptical. In this case, the sealing members 140, 240 and the syringes 90, 290 have inner shapes complementary to the gaskets 100, 200, 300.

[0080] Further, the syringes 90, 290 filled with the medical liquid can be pre-filled syringes. Further, the medical liquid can be manually filled in the syringes 90, 290 or filled in the syringes 90, 290 using the injection head 2 or a filler. Further, the syringes 90, 290 can be provided with a data carrier such as an RFID or a bar code. The data carrier stores information on the medical liquid filled therein. Further, the injection system 1 can read the information stored in the data carrier using the injection head 2 and control the injection amount of the medical liquid. For example, the control device can calculate the optimal injection amount per unit weight based on the information on the medical liquid (iodine amount) read and display the injection amount on the touch panel of the console.

[0081] [Modified Example]

[0082] AsFigure 11 As shown in the figure, a notch 496 can also be formed in part of the outer periphery of the flange 492. Specifically, the flange 492 has two arc portions 497 that are in the shape of a circular arc with respect to the center axis C of the syringe 490. Further, the flange 492 has two flat portions 498 that face each other between the arc portions 497. The flat portions 498 can be formed, for example, by cutting part of the flange 492 in a straight line and parallel. Further, in the substantially central portion of each arc portion 497, a positioning notch 496 is formed in a manner that is point-symmetrical with respect to the center axis C. That is, the notch 496 is formed in a manner that a line segment connecting the two notches 496 is parallel to the flat portion 498. Further, in the adapter 8, a locking claw, a protrusion, or a latch, for example, is provided as an engaging portion that engages with the notch 496.

[0083] The syringe 490 thus configured is fitted into the adapter 8 in a state in which the flange 492 is parallel to the groove of the adapter 8. At this time, the syringe 490 is fitted into the adapter 8 in a manner that the flat portion 498 faces the engaging portion of the adapter 8. Then, the syringe 490 is rotated by 90 degrees so that the engaging portion engages with the notch 496. Thus, the syringe 490 can be mounted to the adapter 8. When the engaging portion engages with the notch 496, the syringe 490 is positioned with respect to the adapter 8 in a manner that the flat portion 498 is horizontal. Thus, the syringe 490 can be properly held in the adapter 8, and damage to the syringe 490 can be prevented. Further, since the plunger 110 can be inhibited from wobbling, the plunger 110 can be inserted straight with respect to the syringe 490. Thus, even in the case of injecting a drug at high pressure, leakage of the drug from the gasket 100 to the outside of the syringe 490 can be inhibited. Alternatively, one or more than three notches 496 can be formed, and the notch 496 can also be formed in the flat portion 498.

[0084] Some or all of the above-described embodiments can also be described as follows, but are not limited to the following.

[0085] (Note 1)

[0086] A method of manufacturing a gasket including a suction member having an insertion portion and an engaging claw, and an O-ring and a sealing member mounted to the suction member, wherein

[0087] The method of manufacturing the gasket includes the steps of:

[0088] The O-ring is mounted in a groove formed in the engaging claw,

[0089] The insertion portion is inserted into a space in the sealing member, and the sealing member is mounted to the insertion portion.

[0090] This application claims priority from Japanese Patent Application No. 2018-171532 filed September 13, 2018, which is incorporated by reference herein in its entirety.

[0091] Explanation of reference signs

[0092] 1, injection system; 2, injection head; 90, syringe; 91, barrel; 100, gasket; 110, plunger; 112, engagement groove; 122, engagement claw; 124, protrusion; 125, annular groove; 126, 1st inner surface; 127, 2nd inner surface; 130, O-ring; 200, gasket; 222, engagement claw; 224, protrusion; 225, annular groove; 295, skirt; 226, 1st inner surface; 227, 2nd inner surface; 290, syringe; 291, barrel; 300, gasket; 322, engagement claw; 328, convex portion; 329, concave portion; 490, syringe; B, boundary portion; H, hole; P, perpendicular line; S1, inner surface; S2, outer surface.

Claims

1. An injection system, wherein, The injection system includes: A sealing gasket having a sealing member, an insertion portion inserted into the sealing member, and a locking claw that is displaced between an expanded position and a contracted position and has a groove forming the starting point of the deformation of the locking claw. The plunger engages with the engagement claw; A cylindrical body for inserting the sealing gasket, and abutting against the engaging claws of the inserted sealing gasket and the sealing member; and An injection device configured to advance the plunger and inject the liquid medicine into the cylinder. The sealing gasket has a disc-shaped protrusion formed between the insertion portion and the groove and protruding outward. The engaging claw has an inwardly protruding projection at a position away from the groove at the rear end of the sealing gasket.

2. The injection system according to claim 1, wherein, The protrusion is formed between the groove and the annular groove formed behind the insertion portion.

3. The injection system according to claim 1, wherein, The groove is an annular groove formed in the sealing gasket.

4. The injection system according to claim 1, wherein, The engaging claw includes: an outer surface that abuts against the cylinder after insertion, and an inner surface that divides the inlet into an enlarged hole for insertion of the plunger. The inner surface includes a first inner surface and a second inner surface, the first inner surface extending from the bottom of the hole, and the second inner surface extending from the first inner surface and inclined relative to the first inner surface in a direction away from the central axis of the hole. The groove is formed at a position corresponding to the boundary portion between the first inner surface and the second inner surface.

5. The injection system according to claim 4, wherein, The outer surface is inclined in a direction away from the central axis.

6. The injection system according to claim 4, wherein, The engaging claw has a protrusion that extends toward the central axis. The plunger has an engagement groove that engages with the protrusion.

7. The injection system according to claim 4, wherein, The first inner surface extends parallel to the central axis.

8. A syringe, wherein, The syringe includes: A sealing gasket having a sealing member, an insertion portion inserted into the sealing member, and an engaging claw that is displaced between an expanded position and a contracted position and has a groove forming the starting point of the deformation of the engaging claw; and A cylindrical body for inserting the sealing gasket, and abutting against the engaging claws of the inserted sealing gasket and the sealing member. The sealing gasket has a disc-shaped protrusion formed between the insertion portion and the groove and protruding outward. The engaging claw has an inwardly protruding projection at a position away from the groove at the rear end of the sealing gasket.

9. A sealing gasket, wherein, The sealing gasket includes: Sealing components; Inserted into the insertion portion of the sealing member; A locking pawl, which is displaced between an expanded position and a contracted position and has a groove forming the starting point of the deformation of the locking pawl; and A disc-shaped protrusion is formed between the insertion portion and the groove and protrudes outward. The engaging claw has an inwardly protruding projection at a position away from the groove at the rear end of the sealing gasket.

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