Preparation method of super-fast self-healing hydrogel dressing with photo-thermal antibacterial effect

Abstract

The application discloses a preparation method of an ultrafast self-healing hydrogel dressing with photothermal antibacterial effect. The application adopts in-situ synthesis and oxidation self-polymerization to prepare an intelligent CMCS / PVA / polydopamine (PDA) hydrogel dressing with multiple dynamic reversible bonds, by taking carboxymethyl chitosan (CMCS) with antibacterial activity and polyvinyl alcohol (PVA) as a hydrogel skeleton, and taking dopamine (DA) and borax as an adhesive and a crosslinking agent. Under near-infrared light irradiation, antibiotics and plant-derived active small molecules and other drugs can not only induce local hyperthermia of polydopamine, but also can realize space-time control of drug release capacity, so that the purpose of precise control is achieved. The hydrogel dressing prepared by the method can realize rapid sterilization, and has excellent biocompatibility, high adhesion, photothermal stability and environmental adaptability, and can be used for protection and treatment of various wounds such as acute and chronic wounds.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of biomaterial preparation, and relates to a preparation method of a multifunctional hydrogel dressing with high adhesion, rapid self-healing, promotion of wound healing and excellent biocompatibility, which has synergistic effects of photothermal and drugs. BACKGROUND

[0002] Skin is the main physical barrier between the human body and the environment, and skin damage is easily infected by bacteria, causes loss of body fluids and various complications, which can affect people's health and even endanger life safety. Wound treatment is still a huge clinical challenge in China and even globally, which has brought a huge financial burden to the government of each country. Although traditional wound dressings such as gauze, bandage and film have been developed and applied in clinics, there are still problems such as single function, secondary injury and inflammation during the replacement process. In practical application, an ideal dressing should meet requirements such as maintaining a moist environment, enhancing epidermal migration, promoting angiogenesis, being able to adhere and be easily removed, preventing bacterial infection and being suitable for different parts. Hydrogel dressings can provide a moist environment for cell growth, multiplication and migration due to their rich 3D structure and promotion of cell hydration for gas and nutrient exchange, which accelerates wound healing. As a biological functional material closest to life tissue, hydrogel can be directly contacted with human tissue, prevent infection of extracorporeal microorganisms, effectively prevent loss of body fluids, and can transmit oxygen to promote wound healing. At the same time, as a drug release carrier, good permeability to low molecular solutes also endows hydrogel with the function of drug delivery system. Due to its excellent biochemical and mechanical properties, hydrogel has become the most competitive candidate material in the field of wound dressings in recent decades and shows an increasing trend year by year, which presents a bright prospect.

[0003] It is always the pursuit of people to design the structure of hydrogel and endow it with functions by physical and chemical cross-linking, so as to realize the hydrogel dressing with multiple functions. Among them, the near-infrared light-thermal hydrogel dressing has become a research hotspot in recent years by precisely controlling the radiation intensity, time and position of near-infrared light to achieve precise control of sterilization. However, it is still a great challenge to develop a multifunctional hydrogel dressing with synergistic effect of photothermal and drug, high adhesion, super-fast self-healing, promoting wound healing and biocompatibility. The current hydrogel dressing can fill the wound and will not form adhesion with the wound, but it will still cause pain to the wounded when it is replaced, especially for large area trauma, it takes a long time to replace the wound dressing, which will cause great mental burden to the patient. At the same time, when it is used under stress and strain, it is easy to appear crack, damage and aging, etc., which will damage the network structure of the gel and lead to the decline of the performance of the gel, limiting its application. In addition, in the design of hydrogel dressing, most of the research mainly considers the mechanical properties and biocompatibility, but the strategy of physical / chemical synergistic treatment of wounds is relatively less, and it has the problems of complex process, high cost, poor antibacterial effect and poor wound healing effect, etc., which limits its further use. SUMMARY

[0004] In view of the deficiencies of the prior art, the present application mainly provides a preparation method of a multifunctional hydrogel dressing with synergistic effect of photothermal and drug, high adhesion, fast self-healing, promoting wound healing and excellent biocompatibility. Based on the dynamic construction theory, carboxymethyl chitosan (CMCS) and polyvinyl alcohol (PVA) are used as raw materials, dopamine (DA) is used as a photothermal adhesive and crosslinking agent, and antibiotics and plant-derived active small molecules are used as model drugs. A drug-loaded CMCS / PVA / polydopamine (CPBD) hydrogel dressing with multiple dynamic cross-linking systems such as borate ester bond, imine bond and hydrogen bond is prepared by simple in-situ synthesis and oxidation self-polymerization. Under near-infrared light irradiation, it can not only induce local thermotherapy of polydopamine, but also achieve the purpose of precise control by spatiotemporal control of drug release. At the same time, the hydrogel dressing also has high adhesion, fast self-healing, stretchability, photothermal stability, excellent antibacterial ability, good biocompatibility and wound healing promoting ability, etc., and is suitable for the protection and treatment of various wounds such as acute and chronic wounds.

[0005] The preparation method of the super-fast self-healing hydrogel dressing with photothermal antibacterial effect comprises the following steps:

[0006] (1) PVA and deionized water are taken into a three-necked flask, and a PVA solution with a certain concentration is formed at a temperature of 95℃. After a period of reaction, the temperature is lowered to a suitable temperature, and a certain mass ratio of CMCS is added into the PVA solution, and stirring is continued to form a transparent solution;

[0007] (2) Adjust the pH value of the above solution with a certain concentration of sodium hydroxide solution, after adjusting to a certain pH value, add different amounts of DA, mix uniformly, and form a transparent solution;

[0008] (3) Finally, a certain amount of crosslinking agent and an appropriate amount of antibiotic and plant-derived active small molecule model drug are added to the above system by using microfluidic technology, and the reaction is incubated for a certain time to obtain the CPBD hydrogel dressing.

[0009] Preferably, the mass ratio of PVA to CMCS in step (1) is 6:0-6:5, the temperature is 30-65℃, and the mechanical stirring speed is 200-600r / min.

[0010] Preferably, the concentration of the sodium hydroxide solution in step (2) is 0.5-2.0mol / L, the pH value of the solution is 7.5-9.5, and DA accounts for 3.0-20.0% of the total mass of PVA and CMCS.

[0011] Preferably, the crosslinking agent in step (2) includes one or more of borax, boric acid, 4-vinylphenylboronic acid containing a phenylboronic acid group, and phenylboronic acid, the concentration of the crosslinking agent is 0.01-0.2mol / L, the total flow rate is 0.6-1.5mL / min; the antibiotic drug includes one or more of amoxicillin, ciprofloxacin hydrochloride, norfloxacin, ticarcillin, gentamicin sulfate, and tobramycin; the plant-derived active small molecule drug includes one or more of tannic acid, anthocyanin, and berberine phosphate; the temperature is 40-70℃, and the reaction time is 10-60min.

[0012] Preferably, the CPBD hydrogel dressing is suitable for anti-infection treatment and protection and treatment of various acute and chronic wounds.

[0013] Compared with the prior art, the present application has the following advantages:

[0014] (1) The preparation method of the present application is simple, easy to operate, and has mild conditions, solving the problem of many by-products in the preparation process of the existing gel dressing, which requires fine operation.

[0015] (2) The CPBD hydrogel dressing obtained by using borate ester bond, imine bond and hydrogen bond and other dynamic covalent bonds and dynamic non-covalent bonds can quickly self-heal, solving the problem of easy cracking, damage and aging under stress-strain action during use. The gel can self-heal within 1min after cutting, and the self-healing efficiency of the cutting-healing within 1min is 80%, the mechanical properties matching the skin are convenient for replacement and fixation, and the CPBD hydrogel dressing is especially suitable for acute and chronic wounds in special areas such as joints and armpits.

[0016] (3) The multifunctional CPBD hydrogel dressing prepared by the application has a rich three-dimensional network structure, which endows it with excellent liquid absorption capacity. The swelling rates in deionized water, physiological saline and phosphate buffer are 4215.00%, 2057.48% and 1203.20%, respectively. On the one hand, the dressing can absorb wound leachate and provide support for cell proliferation and migration and new blood vessel formation; on the other hand, the porous network structure of the hydrogel and the positive charge in CMCS have hemostatic function.

[0017] (4) The multifunctional CPBD hydrogel dressing prepared by the application has excellent adhesion and can adhere to the surface of different materials. It has high bonding strength on the surface of various tissues and organs, solving the problem of difficulty in fixing with tissues.

[0018] (5) The multifunctional CPBD hydrogel dressing prepared by the application has excellent antibacterial performance. Combined with the intrinsic antibacterial properties of CMCS, drug and photothermal synergistic sterilization strategy, when cultured with bacteria for 7 days, the inhibition diameters all show an initial increase and then remain unchanged, and the bactericidal rate of Escherichia coli and Staphylococcus aureus reaches 100%, showing a persistent and effective antibacterial ability. Under near-infrared light irradiation, it not only can induce local hyperthermia effect of polydopamine, but also can control the release of drugs in space and time, achieving the purpose of precise control.

[0019] (6) The multifunctional CPBD hydrogel dressing prepared by the application has good biocompatibility. The cell survival rate of the CPBD hydrogel dressing is more than 100% and the hemolysis rate is less than 5%. Animal experiments show that, combined with photothermal / drug synergistic therapy, the CPBD hydrogel dressing combines photothermal effect with antibiotics and other drugs, which can significantly accelerate wound healing. In 14 days of treatment, the wound healing rate of the photothermal / drug synergistic therapy group reaches 97.4%.

[0020] (7) The multifunctional CPBD hydrogel dressing prepared by the application can be used as wound healing dressing, antibacterial dressing, medical adhesive and artificial tissue skin in the process of wound healing. BRIEF DESCRIPTION OF DRAWINGS

[0021] Figure 1 Electronic scanning electron microscope image of CPBD hydrogel dressing;

[0022] Figure 2 Photothermal performance of CPBD hydrogel dressing;

[0023] Figure 3 Photothermal / drug synergistic antibacterial effect of CPBD hydrogel dressing on Escherichia coli and Staphylococcus aureus; DETAILED DESCRIPTION

[0024] These examples are intended to be illustrative only and the present application is not limited to these examples.

[0025] Example 1

[0026] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 30°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 7.5. Then, 2.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.01 mol / L boric acid was added to the system at a total flow rate of 0.6 mL / min and a tannic acid concentration of 0.5 wt% to react for 0.5 h at a temperature of 40°C to obtain the CPBD hydrogel dressing.

[0027] The results show that the CPBD hydrogel dressing has a three-dimensional network structure, and the swelling rates in deionized water, physiological saline and phosphate buffer are 472.00%, 107.37% and 83.67%, respectively. After the hydrogel is cut, it can be completely self-healed in 30 min. The adhesive strength test shows that the CPBD hydrogel dressing is easy to fall off and has poor adhesive strength. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the antibacterial efficiency is only 74.0%.

[0028] Example 2

[0029] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 30°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 7.5. Then, 2.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.01 mol / L boric acid was added to the system at a total flow rate of 0.6 mL / min and a tannic acid concentration of 0.5 wt% to react for 0.5 h at a temperature of 40°C to obtain the CPBD hydrogel dressing.

[0030] The results show that the CPBD hydrogel dressing has a three-dimensional network structure, and the swelling rates in deionized water, physiological saline and phosphate buffer are 472.00%, 107.37% and 83.67%, respectively. After the hydrogel is cut, it can be completely self-healed in 30 min. The adhesive strength test shows that the CPBD hydrogel dressing is easy to fall off and has poor adhesive strength. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the antibacterial efficiency is only 74.0%.

[0028] Example 2

[0029] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 30°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 7.5. Then, 2.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.01 mol / L boric acid was added to the system at a total flow rate of 0.6 mL / min and a tannic acid concentration of 0.5 wt% to react for 0.5 h at a temperature of 40°C to obtain the CPBD hydrogel dressing.

[0030] The results show that the CPBD hydrogel dressing has a three-dimensional network structure, and the swelling rates in deionized water, physiological saline and phosphate buffer are 472.00%, 107.37% and 83.67%, respectively. After the hydrogel is cut, it can be completely self-healed in 30 min. The adhesive strength test shows that the CPBD hydrogel dressing is easy to fall off and has poor adhesive strength. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the antibacterial efficiency is only 74.0%.

[0031] Example 3

[0032] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 50°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 7.5. Then, 10.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.01 mol / L borax was added to the system at a total flow rate of 0.6 mL / min and a tannic acid concentration of 0.5 wt% to react at a temperature of 40°C for 0.5 h to obtain the CPBD hydrogel dressing.

[0033] The results show that the CPBD hydrogel dressing has a three-dimensional network structure, and the swelling rates in deionized water, physiological saline, and phosphate buffer are 817.45%, 4.96.71%, and 345.67%, respectively. After the hydrogel is cut, it can completely self-heal in 18 min. The bonding strength test shows that the CPBD hydrogel dressing has a certain adhesion to substrates of different materials, and the bonding strength to pigskin is 3.26 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drug is only 75.30%.

[0034] Example 4

[0035] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 50°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 7.5. Then, 10.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.01 mol / L borax was added to the system at a total flow rate of 0.6 mL / min and a tannic acid concentration of 0.5 wt% to react at a temperature of 40°C for 0.5 h to obtain the CPBD hydrogel dressing.

[0036] The results show that the CPBD hydrogel dressing has a three-dimensional network structure, and the swelling rates in deionized water, physiological saline, and phosphate buffer are 817.45%, 4.96.71%, and 345.67%, respectively. After the hydrogel is cut, it can completely self-heal in 18 min. The bonding strength test shows that the CPBD hydrogel dressing has a certain adhesion to substrates of different materials, and the bonding strength to pigskin is 3.26 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drug is only 75.30%.

[0037] Case 5

[0038] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 40°C to form a transparent solution; 0.5 mol / L of sodium hydroxide solution was added to the above solution to make the pH value of the solution 7.5. Subsequently, 10.0% of DA based on the total mass of PVA and CMCS was added to the above solution to form a transparent solution. Finally, 0.01 mol / L of boric acid was added to the above system at a total flow rate of 0.6 mL / min and a concentration of ciprofloxacin hydrochloride of 1.0 wt% to react for 0.5 h at a temperature of 40°C to obtain a CPBD hydrogel dressing.

[0039] The results show that the CPBD hydrogel dressing presents a three-dimensional network structure, and the swelling rates in deionized water, physiological saline and phosphate buffer are 805.68%, 641.28% and 701.41%, respectively. After the hydrogel is cut, it can be completely self-healed in 13 min. The bonding strength test shows that the CPBD hydrogel dressing has a certain adhesion to substrates of different materials, and the bonding strength to pigskin is 3.26 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drug is only 86.30%.

[0040] Case 6

[0041] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 50°C to form a transparent solution; 0.5 mol / L of sodium hydroxide solution was added to the above solution to make the pH value of the solution 7.5. Subsequently, 10.0% of DA based on the total mass of PVA and CMCS was added to the above solution to form a transparent solution. Finally, 0.1 mol / L of borax was added to the above system at a total flow rate of 0.6 mL / min and a concentration of ciprofloxacin hydrochloride of 1.0 wt% to react for 0.5 h at a temperature of 40°C to obtain a CPBD hydrogel dressing.

[0042] The results show that the CPBD hydrogel dressing has a certain adhesion to substrates of different materials, and the bonding strength to pigskin is 1.78 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drug is only 83.27%.

[0043] Case 7

[0044] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 50°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 8.5. Then, 10.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.1 mol / L boric acid was added to the system at a total flow rate of 1.3 mL / min and a concentration of ciprofloxacin hydrochlorate of 1.0 wt% to react for 0.5 h at a temperature of 40°C to obtain a CPBD hydrogel dressing.

[0045] The results show that the swelling rates of the CPBD hydrogel dressing in deionized water, normal saline and phosphate buffer are 1298.33%, 531.76% and 516.11%, respectively. After the hydrogel is cut, it can be completely self-healed in 13 min. The bonding strength test shows that the bonding strength of the CPBD hydrogel dressing to pigskin is 6.59 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drugs is only 83.48%.

[0046] Embodiment 8

[0047] PVA and deionized water were added to a three-necked flask to form a PVA solution at a temperature of 95°C. After 1 h of reaction, the temperature was lowered to 50°C to form a transparent solution. A 0.5 mol / L sodium hydroxide solution was added to the solution to adjust the pH of the solution to 8.5. Then, 10.0% of DA based on the total mass of PVA and CMCS was added to the solution to form a transparent solution. Finally, 0.1 mol / L boric acid was added to the system at a total flow rate of 1.3 mL / min and a concentration of ciprofloxacin hydrochlorate of 1.0 wt% to react for 0.5 h at a temperature of 40°C to obtain a CPBD hydrogel dressing.

[0048] The results show that the CPBD hydrogel dressing presents a three-dimensional network structure, and the swelling rates in deionized water, normal saline and phosphate buffer are 1361.46%, 626.33% and 774.19%, respectively. After the hydrogel is cut, it can be completely self-healed in 15 min. The bonding strength test shows that the CPBD hydrogel dressing has a certain adhesion to substrates of different materials, and the bonding strength to pigskin is 3.26 KPa. At the same time, the CPBD hydrogel dressing has a certain antibacterial effect on E. coli and S. aureus, but the synergistic antibacterial efficiency of photothermal and drugs is only 84.60%.

[0049] Embodiment 9

[0050] PVA and deionized water were added into a three-necked flask to form a PVA solution at a temperature of 95 °C. After 1 h of reaction, the temperature was reduced to 50 °C to form a transparent solution; 0.5 mol / L sodium hydroxide solution was added to the above solution to make the pH value of the solution 8.5. Subsequently, 20.0% of DA based on the total mass of PVA and CMCS was added to the above solution to form a transparent solution. Finally, 0.15 mol / L borax was added to the above system at a total flow rate of 1.0 mL / min and a concentration of ciprofloxacin hydrochloride of 1.5 wt% at a temperature of 45 °C for 1.0 h to obtain the CPBD hydrogel dressing.

[0051] The results show that the CPBD hydrogel dressing presents a three-dimensional network structure, and the swelling rates in deionized water, physiological saline and phosphate buffer are 4215.12%, 2057.48% and 1203.42%, respectively. After cutting the hydrogel, it can achieve complete self-healing in 1 min, and the self-healing efficiency of 5 cycles of stretching in 1 min is about 80%. The bonding strength of the CPBD hydrogel dressing to metal, wood, glass and pigskin surfaces is 11.02 kPa, 791.66 kPa, 67.65 kPa and 7.85 kPa, respectively. Under 808 nm near-infrared light irradiation, the temperature of the CPBD hydrogel dressing is about 40.8 °C, and after five cycles of alternating irradiation, the hydrogel has good photothermal stability. Tensile stress experiments show that it has good tensile properties, with a tensile stress and elongation at break of 39.48 kPa and 246.26%, respectively. In addition, it also has excellent photothermal antibacterial ability (bactericidal rate close to 100%), good biocompatibility (cell survival rate greater than 100% and hemolysis rate less than 1.75%), and the ability to promote wound healing (when treated with photothermal and drugs in synergy, the wound healing rate of rats is 97.4%).

Claims

1. A method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties, characterized in that, The method is performed in the following steps: (1) Add polyvinyl alcohol (PVA) and deionized water to a three-necked flask and heat at 95°C to form a solution of a certain concentration. After reacting with the PVA solution for a period of time, the temperature is lowered to a suitable level. A certain mass ratio of carboxymethyl chitosan (CMCS) is added to the PVA solution, and mechanical stirring continues to form a homogeneous and transparent solution. (2) Adjust the pH value of the above solution with a certain concentration of sodium hydroxide solution. After adjusting to a certain pH value, add different amounts of dopamine (DA), mix well, and form a transparent solution. (3) Finally, a certain amount of crosslinking agent and appropriate amounts of antibiotics and plant-derived active drugs were added to the above system using microfluidic technology, and the reaction was kept at a certain temperature for a certain time to obtain CMCS / PVA / polydopamine CPBD hydrogel. The plant-derived active pharmaceutical ingredient contains one or more of tannic acid, anthocyanins, and berberine hydrochloride.

2. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... The suitable temperature in step (1) is 30 ~ 65℃, and the mechanical stirring speed is 200 ~ 600r / min.

3. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... In step (2), the pH value is adjusted and DA is added in different mass ratios, wherein the concentration of sodium hydroxide solution is 0.5 ~ 2.0 mol / L, the pH value of the solution is 7.5 ~ 9.5, and DA accounts for 3.0 ~ 25.0% of the total mass of PVA and CMCS.

4. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... In step (3), a certain amount of crosslinking agent is applied using microfluidic technology. The crosslinking agent includes one or more of borax, boric acid, phenylboronic acid and 4-vinylphenylboronic acid containing phenylboronic acid groups. The concentration of the crosslinking agent is 0.01 ~ 0.2 mol / L, and the total flow rate is 0.6 ~ 1.5 mL / min.

5. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... In step (3), appropriate amounts of antibiotics and plant-derived active drugs are added to the above system, wherein the antibiotics include one or more of amoxicillin, ciprofloxacin hydrochloride, norfloxacin, ticarcillin, gentamicin sulfate and tobramycin.

6. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... The content of appropriate amounts of antibiotics and plant-derived active drugs in step (3) is 0.5 ~ 2.0 wt%.

7. The method for preparing an ultra-fast self-healing hydrogel dressing with both photothermal and antibacterial properties according to claim 1, characterized in that... In step (3), the reaction is kept at a constant temperature for a certain period of time, with the temperature being 40 ~ 70℃ and the reaction time being 0.5 ~ 2.0h.

8. An ultra-fast self-healing hydrogel dressing with photothermal antibacterial properties, prepared by the method described in any one of claims 1 to 6.

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