A mouse anesthesia and radiotherapy test device

Abstract

The present application relates to the technical field of mouse experiment, especially to a mouse anesthesia and radiotherapy experiment device, which comprises a first shell and a second shell which are mutually inserted and matched, sliding openings are formed in the upper edges of the first shell and the second shell respectively, a sliding block is slidably arranged in one of the sliding openings, the inner wall of the other sliding opening is engaged with the side edge of the sliding block, an oscillating rod is movably penetrated into the inner side of the sliding block, a sticking disc is fixedly connected to the lower end of the oscillating rod, a soft sleeve is arranged at the rear end of the first shell and the second shell, and a gas supply pipeline is arranged at the front end of the first shell and the second shell, the mouse can be conveniently fixed or removed, the anesthesia and the post-removal radiotherapy steps can be quickly performed, the concentration and the time length of the anesthetic can be accurately controlled, whether the mouse is anesthetized can be verified in time, and the accuracy of the experiment is improved.

Description

Technical Field

[0001] This invention relates to the field of mouse testing technology, and in particular to a device for testing mouse anesthesia and radiotherapy. Background Technology

[0002] Mice are one of the most commonly used laboratory animals and play an important role in research related to tumor radiotherapy. Generally, mice are anesthetized before being irradiated to specific areas depending on the research objective. In experiments involving anesthesia and radiotherapy in mice, anesthetic gases are used to induce unconsciousness. The mice are then positioned with their mouths aligned with the nozzles through which the anesthetic gas is inhaled. However, controlling the duration and concentration of gas inhalation requires multiple trials. In controlled variable experiments, multiple mice are used each time to avoid individual cases affecting the anesthesia results. Mice are naturally agile and active, making it difficult to fix them in place and to precisely control the concentration and duration of the gas inhaled by the mice. Based on these issues, we propose a device for experimental anesthesia and radiotherapy in mice. Summary of the Invention

[0003] The purpose of this invention is to address the shortcomings of the prior art by providing a mouse anesthesia and radiotherapy experimental device.

[0004] To achieve the above objectives, the technical solution adopted by the present invention is as follows: a mouse anesthesia and radiotherapy experimental device, comprising a first shell and a second shell that are inserted and fitted together. The upper sides of the first shell and the second shell are respectively provided with sliding openings. A slider is slidably disposed in one of the sliding openings, and the inner wall of the other sliding opening is engaged with the side of the slider. A swing rod is movably passed through the inner side of the slider. A patch is fixedly connected to the lower end of the swing rod. A soft sleeve is provided at the rear end of the first shell and the second shell. An air supply pipe is connected to the front end of the first shell and the second shell.

[0005] Preferably, a locking strip is fixedly provided on the inner wall of one of the sliding openings, and a convex groove is provided on one side of the slider. The locking strip slides through the inner side of the convex groove. A rack is fixedly provided on the inner wall of the other sliding opening, and a locking slot is provided on the other side of the slider. The inner wall of the locking slot is provided with teeth, and the teeth mesh with the rack.

[0006] Preferably, the inner side of the slider is provided with a spherical groove, a ball is slidably inserted into the inner side of the spherical groove, the swing rod passes through the ball and the two are threaded together, and a handle is fixedly connected to the upper end of the swing rod.

[0007] Preferably, the soft sleeve includes a diaphragm fixedly connected to the inner wall of the first housing or the second housing, and an elastic band fixedly disposed on the edge of the diaphragm, wherein both the diaphragm and the elastic band are made of rubber.

[0008] Preferably, a fixing block is fixedly provided on the upper surface of the first housing, and a fixing seat is fixedly provided on the upper surface of the second housing. A movable groove is provided on the inner side of the fixing seat, and a slot is provided on one side of the movable groove. An insert is protruding on one side of the fixing block, and the insert is slidably inserted into the inner side of the slot and fixed by a locking mechanism.

[0009] Preferably, the locking mechanism includes a rod that slides through the side of the fixed seat. After passing through the inner side of the movable groove, the rod slides through the inner side of the insert block. A baffle is protruding from the outer surface of the rod. A compression spring is sleeved on the outer side of the rod. The compression spring is located between the side wall of the movable groove and one side of the baffle. A connector is fixedly connected to the end of the rod.

[0010] Preferably, the gas supply pipeline includes a main pipe and a branch pipe fixedly connected to the main pipe. The rear end of the branch pipe is threadedly engaged with the front end of the first housing and the second housing. A gate valve is provided inside the branch pipe, and a valve stem is provided on the upper side of the gate valve. The valve stem is rotatably engaged with the branch pipe. The main pipe is connected to a connector.

[0011] Preferably, the front ends of the first housing and the second housing respectively extend into a rotary joint, and the rear end of the branch pipe is rotatably connected to a rotary sleeve via a connecting ring, wherein the rotary joint and the rotary sleeve are threadedly engaged.

[0012] Preferably, the lower surface of the main tube is fixedly connected to the support plate, and the upper surface of the support plate is provided with a plurality of wide slots, each group having two wide slots. A narrow slot is provided at the rear end of the wide slot. Slide plates are fixedly connected to the lower surfaces of the first housing and the second housing, respectively. The slide plates slide through the upper end of the narrow slot. The slide plates slide in contact with the inner sides of both the narrow slot and the wide slot. A pad is provided on the lower surface of the support plate.

[0013] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention can conveniently fix or remove mice, quickly perform anesthesia and radiotherapy after removal, accurately control the concentration and duration of anesthetic, and promptly verify whether the mice are anesthetized, thus improving the accuracy of the experiment.

[0014] Beforehand, rotate the sleeve to move the first and second housings backward and remove them. Pull the connector to disengage the insert from the insert block. Then, pull the insert block out of the slot to complete the separation between the first and second housings. At this point, the mouse's half-body can be placed between the elastic bands on both sides. Then, close the first and second housings, reset the insert block, reset the sleeve and the screw connector, and introduce anesthetic gas into the main tube and into the branch tube to anesthetize each mouse confined between the first and second housings. Therefore, simultaneous experiments with multiple mice can be conducted to precisely control the anesthetic concentration and duration.

[0015] After the mouse is sandwiched between the first and second shells, the patch is fixed to the mouse's head with glue or straps. In the anesthesia test, the mouse's reaction to touching the swing bar is observed to determine whether it has been anesthetized. That is, when the mouse is relatively still, the anesthesia can be verified by touching the swing bar to prevent misidentification. Therefore, the anesthesia judgment of the mouse is more accurate during the test, thus improving the accuracy of the test.

[0016] When the first and second housings are separated, the slider can slide along the locking strip to adjust its position in the sliding opening, which in turn adjusts the position of the lower adhesive plate, ensuring that the lower surface of the adhesive plate can be attached to the mouse's head. After the first and second housings are closed, the slider is locked in place due to the engagement of the teeth and the rack. That is, the slider is locked in place simultaneously with the docking of the first and second housings. It is flexible, convenient and adaptable. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the structure of a mouse anesthesia and radiotherapy experimental device according to the present invention; Figure 2 This is a partial structural schematic diagram of a mouse anesthesia and radiotherapy experimental device according to the present invention; Figure 3 This is a cross-sectional view of the sleeve and branch tube of a mouse anesthesia and radiotherapy experimental device of the present invention; Figure 4 This is a schematic diagram showing the disassembled first and second housings of a mouse anesthesia and radiotherapy experimental device of the present invention; Figure 5 This is a schematic diagram of the second housing of a mouse anesthesia and radiotherapy experimental device according to the present invention; Figure 6 This is a partial cross-sectional view of the first and second housings of a mouse anesthesia and radiotherapy experimental device of the present invention after docking; Figure 7 This invention relates to a mouse anesthesia and radiotherapy experimental device. Figure 6 Enlarged view of point A in the middle; Figure 8 This is a schematic diagram of the slider of a mouse anesthesia and radiotherapy experimental device according to the present invention; Figure 9 This is a cross-sectional view of the docking point between the first and second housings of a mouse anesthesia and radiotherapy experimental device of the present invention; Figure 10 This invention relates to a mouse anesthesia and radiotherapy experimental device. Figure 9 Enlarged view at point B in the middle; Figure 11 This is a partial side sectional view of the first and second shells of a mouse anesthesia and radiotherapy experimental device of the present invention; Figure 12 This is a schematic diagram of mouse fixation in a mouse anesthesia and radiotherapy experimental device of the present invention. Figure 1 ; Figure 13 This is a schematic diagram of mouse fixation in a mouse anesthesia and radiotherapy experimental device of the present invention. Figure 2 .

[0018] 1. First housing; 2. Second housing; 3. Diaphragm; 4. Elastic band; 5. Slide; 6. Slider; 7. Bayonet; 8. Toothed groove; 9. Convex groove; 10. Inserting bar; 11. Spherical groove; 12. Inserting ball; 13. Swing rod; 14. Plate; 15. Handle; 16. Rack; 17. Fixing block; 18. Inserting block; 19. Fixing seat; 20. Movable groove; 21. Slot; 22. Inserting rod; 23. Baffle; 24. Compression spring; 25. Connector; 26. Rotary joint; 27. Rotary sleeve; 28. Branch pipe; 29. ​​Connecting ring; 30. Gate valve; 31. Valve stem; 32. Support plate; 33. Slide plate; 34. Wide groove; 35. Narrow groove; 36. Main pipe; 37. Connector; 38. Pad. Detailed Implementation

[0019] The following description is intended to disclose the invention and enable those skilled in the art to implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art.

[0020] like Figures 1-13 The device shown is a mouse anesthesia and radiotherapy experimental device, including a first shell 1 and a second shell 2 that are inserted and fitted together. The upper sides of the first shell 1 and the second shell 2 are respectively provided with sliding openings 5. A slider 6 is slidably disposed in one of the sliding openings 5, and the inner wall of the other sliding opening 5 is engaged with the side of the slider 6. A swing rod 13 is movably passed through the inner side of the slider 6. A patch 14 is fixedly connected to the lower end of the swing rod 13. A soft sleeve is provided at the rear end of the first shell 1 and the second shell 2. An air supply pipe is connected to the front end of the first shell 1 and the second shell 2.

[0021] This invention allows for convenient fixation or removal of mice, rapid anesthesia and subsequent radiotherapy, precise control of anesthetic concentration and duration, and timely verification of mouse anesthesia, thereby improving the accuracy of experiments.

[0022] like Figure 7 , Figure 8 , Figure 9 As shown, a locking strip 10 is fixedly installed on the inner wall of one sliding opening 5, and a convex groove 9 is opened on one side of the slider 6. The locking strip 10 slides through the inner side of the convex groove 9. A rack 16 is fixedly installed on the inner wall of the other sliding opening 5, and a locking slot 7 is opened on the other side of the slider 6. The inner wall of the locking slot 7 is provided with teeth 8. The teeth 8 mesh with the rack 16 to prevent the slider 6 from sliding relative to each other.

[0023] The inner side of the slider 6 is provided with a spherical groove 11, and a retaining ball 12 is slidably inserted into the inner side of the spherical groove 11. The swing rod 13 passes through the retaining ball 12 and the two are threaded together. The upper end of the swing rod 13 is fixedly connected to a handle 15, which is convenient to hold the upper end of the swing rod 13 during use. When the retaining ball 12 is pressed with a finger, the swing rod 13 can be rotated to move it up and down, thereby adjusting the height of the adhesive plate 14 and ensuring that it is properly attached to the mouse's head.

[0024] like Figure 4 , Figure 5 As shown, the soft sleeve includes a diaphragm 3 fixedly connected to the inner wall of the first shell 1 or the second shell 2, and an elastic band 4 fixedly disposed on the edge of the diaphragm 3. Both the diaphragm 3 and the elastic band 4 are made of rubber, which has high friction and good elasticity, making it difficult for the mouse to break free. The soft texture plays a protective role when the mouse's half body is clamped at the port of the first shell 1 and the second shell 2.

[0025] like Figure 9 , Figure 10 As shown, a fixing block 17 is fixedly installed on the upper surface of the first housing 1, and a fixing seat 19 is fixedly installed on the upper surface of the second housing 2. A movable groove 20 is opened on the inner side of the fixing seat 19, and a slot 21 is opened on one side of the movable groove 20. An insert block 18 protrudes from one side of the fixing block 17. The insert block 18 slides into the inner side of the slot 21 and is fixed by a locking mechanism. The locking mechanism includes an insert rod 22 that slides through the side of the fixing seat 19. After passing through the inner side of the movable groove 20, the insert rod 22 slides through the inner side of the insert block 18. A baffle 23 protrudes from the outer surface of the insert rod 22, and a compression spring 24 is sleeved on the outer side of the insert rod 22. The compression spring 24 is located between the side wall of the movable groove 20 and one side of the baffle 23. A connector 25 is fixedly connected to the end of the insert rod 22. The compression spring 24 is used to reset. After pulling the insert rod 22, when the hand is released, the insert rod 22 will reset under the action of the compression spring 24.

[0026] like Figure 1 , Figure 2 As shown, the gas supply pipeline includes a main pipe 36 and a branch pipe 28 fixedly connected to the main pipe 36. The rear end of the branch pipe 28 is threadedly engaged with the front end of the first housing 1 and the second housing 2. A gate valve 30 is installed inside the branch pipe 28. A valve stem 31 is installed on the upper side of the gate valve 30, and the valve stem 31 is rotatably engaged with the branch pipe 28. The main pipe 36 is connected to a connector 37, which is used to connect with the gas supply equipment.

[0027] like Figure 3 As shown, the front ends of the first housing 1 and the second housing 2 extend out of the screw joints 26 respectively. The rear end of the branch pipe 28 is rotatably connected to the sleeve 27 through the connecting ring 29. The screw joints 26 and the sleeve 27 are threadedly engaged. By rotating the sleeve 27 and cooperating with the translation of the first housing 1 and the second housing 2, the docking and disassembly between the screw joints 26 and the sleeve 27 can be completed.

[0028] like Figure 1 As shown, the lower surface of the main tube 36 is fixedly connected to the support plate 32. The upper surface of the support plate 32 is provided with several sets of wide grooves 34, with two wide grooves in each set. A narrow groove 35 is provided at the rear end of the wide groove 34. The lower surfaces of the first housing 1 and the second housing 2 are respectively fixedly connected with sliding plates 33. The sliding plates 33 slide through the upper end of the narrow groove 35. The sliding plates 33 slide in cooperation with the inner sides of the narrow groove 35 and the wide groove 34. A pad 38 is provided on the lower surface of the support plate 32. The first housing 1 and the second housing 2 slide forward along the direction of the narrow groove 35 until the sliding plates 33 slide completely into the wide groove 34. Then, the first housing 1 and the second housing 2 can be lifted up and removed to facilitate the subsequent fixation or removal of the mouse.

[0029] Before rotating the sleeve 27, move the first housing 1 and the second housing 2 backward and remove them. Pull the connector 25 so that the insertion rod 22 is disengaged from the insertion block 18. Then, the insertion block 18 can be pulled out of the slot 21 to complete the separation between the first housing 1 and the second housing 2. At this time, the mouse's half-body position can be placed between the elastic bands 4 on both sides. Then, close the first housing 1 and the second housing 2, reset the insertion block 18, reset the sleeve 27 and the screw connector 26, and introduce anesthetic gas into the main tube 36 and into the branch tube 28 to anesthetize each mouse confined between the first housing 1 and the second housing 2. During this process, the sliding port 5 is used to balance the internal air pressure and allow excess gas to be discharged. Due to the continuous introduction and discharge of anesthetic gas, the concentration of anesthetic gas inside the first housing 1 and the second housing 2 is hardly affected by the gas flow at the sliding port 5, and the accuracy of the experiment can still be guaranteed. Therefore, multiple mice can be tested simultaneously to accurately control the anesthesia concentration and duration. After the mouse is sandwiched between the first shell 1 and the second shell 2, the adhesive plate 14 is secured to the mouse's head with glue or straps, such as... Figure 12 , Figure 13 As shown, in the anesthesia experiment, the mouse's reaction and anesthesia status are observed by touching the swing rod 13. This verification is possible when the mouse is relatively still, preventing misidentification. Therefore, the anesthesia assessment of the mouse is more accurate, improving the overall accuracy of the experiment. When the first shell 1 and the second shell 2 separate, the slider 6 can slide along the locking strip 10, adjusting its position in the sliding opening 5. This adjusts the position of the lower adhesive plate 14, ensuring its lower surface adheres to the mouse's head. After the first shell 1 and the second shell 2 are closed, the slider 6 is locked in place by the engagement of the teeth 8 and the rack 16. This simultaneous locking of the slider 6 with the docking of the first shell 1 and the second shell 2 makes the experiment flexible, convenient, and adaptable.

[0030] The foregoing has shown and described the basic principles, main features, and advantages of the present invention. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The embodiments and descriptions in the specification are merely principles of the invention. Various changes and modifications can be made to the invention without departing from its spirit and scope, and all such changes and modifications fall within the scope of the claimed invention. The scope of protection claimed by the appended claims and their equivalents is defined.

Claims

1. A mouse anesthesia and radiotherapy experimental device, characterized in that: The device includes a first housing (1) and a second housing (2) that are inserted into each other. The upper sides of the first housing (1) and the second housing (2) are respectively provided with sliding openings (5). A slider (6) is slidably disposed in one of the sliding openings (5). The inner wall of the other sliding opening (5) is engaged with the side of the slider (6). A spherical groove (11) is provided on the inner side of the slider (6). A ball (12) is slidably inserted into the inner side of the spherical groove (11). A swing rod (13) passes through the ball (12) and the two are threaded together. A handle (15) is fixedly connected to the upper end of the swing rod (13). A plate (14) is fixedly connected to the lower end of the swing rod (13). A soft sleeve is provided at the rear end port of the first housing (1) and the second housing (2). An air supply pipe is connected to the front end of the first housing (1) and the second housing (2). The gas supply pipeline includes a main pipe (36) and a branch pipe (28) fixedly connected to the main pipe (36). The rear end of the branch pipe (28) is threadedly engaged with the front end of the first housing (1) and the second housing (2). A gate valve (30) is provided inside the branch pipe (28). A valve stem (31) is provided on the upper side of the gate valve (30), and the valve stem (31) is rotatably engaged with the branch pipe (28). A connector (37) is connected to the main pipe (36). The lower surface of the main tube (36) is fixedly connected to the support plate (32). The upper surface of the support plate (32) is provided with several sets of wide grooves (34), each set of wide grooves (34) has two grooves. The rear end of the wide groove (34) is provided with a narrow groove (35). The lower surfaces of the first housing (1) and the second housing (2) are respectively fixedly connected with sliding plates (33). The sliding plates (33) slide through the upper end port of the narrow groove (35). The sliding plates (33) slide in cooperation with the inner side of the narrow groove (35) and the wide groove (34). The lower surface of the support plate (32) is provided with a pad (38).

2. The mouse anesthesia and radiotherapy experimental device according to claim 1, characterized in that: A locking strip (10) is fixedly provided on the inner wall of one of the sliding openings (5). A convex groove (9) is provided on one side of the slider (6). The locking strip (10) slides through the inner side of the convex groove (9). A rack (16) is fixedly provided on the inner wall of the other sliding opening (5). A locking slot (7) is provided on the other side of the slider (6). A toothed pattern (8) is provided on the inner wall of the locking slot (7). The toothed pattern (8) meshes with the rack (16).

3. The mouse anesthesia and radiotherapy experimental device according to claim 1, characterized in that: The soft sleeve includes a diaphragm (3) fixedly connected to the inner wall of the first housing (1) or the second housing (2) and an elastic band (4) fixedly disposed on the edge of the diaphragm (3). Both the diaphragm (3) and the elastic band (4) are made of rubber.

4. The mouse anesthesia and radiotherapy experimental device according to claim 1, characterized in that: A fixing block (17) is fixedly provided on the upper surface of the first housing (1), and a fixing seat (19) is fixedly provided on the upper surface of the second housing (2). A movable groove (20) is provided on the inner side of the fixing seat (19), and a slot (21) is provided on one side of the movable groove (20). An insert (18) is protruding on one side of the fixing block (17). The insert (18) slides into the inner side of the slot (21) and is fixed by a locking mechanism.

5. The mouse anesthesia and radiotherapy experimental device according to claim 4, characterized in that: The locking mechanism includes a sliding rod (22) that slides through the side of the fixed base (19). The rod (22) passes through the inner side of the movable groove (20) and then slides through the inner side of the insert block (18). A baffle (23) is protruding from the outer surface of the rod (22). A compression spring (24) is sleeved on the outer side of the rod (22). The compression spring (24) is located between the side wall of the movable groove (20) and one side of the baffle (23). A connector (25) is fixedly connected to the end of the rod (22).

6. The mouse anesthesia and radiotherapy experimental device according to claim 1, characterized in that: The front ends of the first housing (1) and the second housing (2) extend out of the screw joints (26), and the rear end of the branch pipe (28) is rotatably connected to the sleeve (27) through the connecting ring (29). The screw joints (26) and the sleeve (27) are threaded together.

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