Automatic analysis device

Abstract

The present application provides an automatic analysis device that can suppress the risk of contamination of the reagent and can perform a high-throughput dispensing operation. The automatic analysis device can perform a first dispensing operation or a second dispensing operation, and the second dispensing operation includes: a first step (B1), using a dispensing nozzle (201) to suck the test body contained in the test body container (5); a second step (B2), discharging the sucked test body into the first reaction container (2a); a third step (B3), after the second step, cleaning the inside and outside of the dispensing nozzle by a cleaning tank; a fourth step (B4), after the third step, using the dispensing nozzle to suck the reagent contained in the reagent container (4); a fifth step (B5), after the fourth step, cleaning the outside of the dispensing nozzle by a cleaning tank; a sixth step (B6), after the fifth step, using the dispensing nozzle to suck the test body contained in the first reaction container; and a seventh step (B7), discharging the reagent and test body sucked in the fourth and sixth steps into the second reaction container (2b).

Description

Technical Field

[0001] This invention relates to an automatic analysis device. Background Technology

[0002] As automated analytical devices, biochemical analytical devices and immunoassay devices are known for analyzing the biological components contained in test samples such as blood and urine. In automated analytical devices, the concentration of the mixture produced by the reaction of the sample with the mixture used in the analysis of each test item, the activity of enzymes, etc., are optically measured.

[0003] Patent Document 1 discloses an automatic analysis device that uses dispensing mechanisms separately based on the reaction process, and each dispensing mechanism dispenses the sample and reagent using the same dispensing nozzle, and mixes the sample and reagent mixture by pipetting.

[0004] Prior art literature

[0005] Patent documents

[0006] Patent Document 1: International Publication No. 2020 / 217636 Summary of the Invention

[0007] The problem that the invention aims to solve

[0008] The inventors studied the dispensing sequence of the automatic analysis device disclosed in Patent Document 1, which can improve its throughput. Cleaning the inside and outside of the dispensing nozzle during each dispensing action leads to a decrease in throughput and an increase in the amount of cleaning water used. Therefore, it is preferable to perform dispensing actions that minimize the number of cleaning operations.

[0009] Therefore, a sequence was investigated involving first drawing reagent from the reagent container, cleaning only the outside of the dispensing nozzle, then drawing the test sample from the test sample container, discharging the drawn reagent and test sample into the reaction vessel, and stirring. The results showed that in some tests, carryover contamination between the reagent and the test sample can occur. For example, the turbidimetric reagent may contain protein. According to the above sequence, if the turbidimetric reagent adhering to the inside of the dispensing nozzle mixes into the test sample in the test sample container, even if the amount of protein is trace, in cases where the protein concentration is low, such as urine, the mixed turbidimetric reagent could lead to erroneous measurement results such as falsely high values.

[0010] Solution for solving the problem

[0011] An automatic analysis apparatus according to one embodiment of the present invention includes: a dispensing mechanism having a dispensing nozzle for dispensing a detector or reagent into a reaction vessel; a cleaning tank for cleaning the dispensing nozzle; and a control unit for controlling the dispensing mechanism and the cleaning tank in a manner that dispenses the detector and reagent into the reaction vessel via a first dispensing action or a second dispensing action.

[0012] The first dispensing action includes: a first step in which the dispensing mechanism uses a dispensing nozzle to draw in the reagent contained in the reagent container; a second step in which, after the first step, a cleaning tank cleans the outside of the dispensing nozzle; a third step in which, after the second step, the dispensing mechanism uses the dispensing nozzle to draw in the detector container the detector; and a fourth step in which, after the third step, the dispensing mechanism discharges the reagent and detector drawn in the first and third steps into the reaction vessel.

[0013] The second dispensing action includes: a first step in which the dispensing mechanism uses a dispensing nozzle to draw in the detector contained in the detector container; a second step in which, after the first step, the dispensing mechanism discharges the detector drawn in the first step into the first reaction container; a third step in which, after the second step, a cleaning tank cleans the inside and outside of the dispensing nozzle; a fourth step in which, after the third step, the dispensing mechanism uses a dispensing nozzle to draw in the reagent contained in the reagent container; a fifth step in which, after the fourth step, a cleaning tank cleans the outside of the dispensing nozzle; a sixth step in which, after the fifth step, the dispensing mechanism uses a dispensing nozzle to draw in the detector contained in the first reaction container; and a seventh step in which, after the sixth step, the dispensing mechanism discharges the reagent and detector drawn in the fourth and sixth steps into the second reaction container.

[0014] Invention Effects

[0015] An automated analysis device is provided that can suppress the risk of reagent contamination and perform high-throughput dispensing operations.

[0016] Other issues and new features are made clear from the description and accompanying drawings in this specification. Attached Figure Description

[0017] Figure 1 This is a schematic diagram of the mechanism related to the dispensing mechanism in the automatic analysis device.

[0018] Figure 2A These are the steps involved in a typical betting action.

[0019] Figure 2B This is a step in the dispensing process to avoid carrying contamination.

[0020] Figure 3A This is a diagram illustrating the standard attraction action.

[0021] Figure 3BThis is a diagram showing a small number of attraction actions.

[0022] Figure 4 This is an example of measuring commissioned information data.

[0023] Figure 5A This is an example of a decision table.

[0024] Figure 5B This is an example of a decision table. Detailed Implementation

[0025] Hereinafter, embodiments of the present invention will be described using the accompanying drawings. It should be noted that in the various figures, common components and identical components are labeled with the same reference numerals, and repeated descriptions are omitted where appropriate.

[0026] Figure 1 The structure related to the dispensing mechanism in the automated analysis device is briefly shown. Figure 1 In this system, reaction vessels 2 are arranged in a circular pattern around the culture vessel (reaction tray) 1. Reaction vessels 2 are containers used in all reactions. The culture vessel 1 is controlled to rotate via a drive mechanism such as a motor.

[0027] The reagent / detector shared storage unit 3 can hold multiple reagent bottles 4b and detector containers 5. The reagent bottles 4b are formed by combining multiple (here, three) reagent containers 4, each containing a reagent. In this example, the reagent bottles 4b are located on the inner periphery of the detector containers 5, but the detector containers 5 can be located on the inner periphery of the reagent bottles 4b, or the reagent bottles 4b and detector containers 5 can be arranged separately in the circumferential direction, not radially. Furthermore, while an example of the reagent / detector shared storage unit 3 is shown here, the storage units for reagents and detectors can be different.

[0028] A dispensing mechanism 6, equipped with a dispensing nozzle, is provided between the culture vessel 1 and the reagent / detector shared storage section 3, capable of both circular (rotational) and vertical movement. The dispensing nozzle moves while tracing an arc around the rotation axis, dispensing reagents from the reagent bottle 4b or the detector container 5 into the reaction vessel 2. Along the dispensing nozzle's track are a reagent aspiration position and a detector aspiration position on the reagent / detector shared storage section 3, a dispensing position on the culture vessel 1, and a cleaning tank 7 for cleaning the dispensing nozzle.

[0029] The test substance and reagent are aspirated through a dispensing nozzle, and then stirred and mixed by a suction discharge action within the reaction vessel 2 based on the dispensing nozzle. This method of mixing the test substance and reagent via pipetting through the dispensing nozzle eliminates the need for a separate stirring mechanism. The reaction vessel 2, containing the reaction solution containing the mixed test substance and reagent, is maintained at a specified temperature by the incubator 1, promoting the reaction for a specified time.

[0030] When the automated analyzer is used for biochemical testing, a spectrophotometer 8 is arranged around the culture vessel 1. The spectrophotometer 8 includes a light source (not shown) and a detector. It measures the absorbance of the reaction solution by scattering and detecting the transmitted light obtained by irradiating the light source with a reaction solution containing the test substance and reagent. It should be noted that the detection principle of the automated analyzer is not limited to biochemical testing. For example, when the automated analyzer is used for immunoassay, the spectrophotometer 8 is not required; an immunoassay unit is provided (e.g., using electrochemiluminescence or chemiluminescence principles, a photomultiplier tube is used as a detector to measure the amount of light emitted from the luminescent reaction of the labeled substance). Furthermore, when the automated analyzer is a combined type for biochemical and immunoassay testing, both the spectrophotometer 8 and the immunoassay unit are provided.

[0031] Each mechanism of the automated analysis device is connected to the control unit 10. The control unit 10 controls the operation of various mechanisms, including the rotation drive of the culture vessel 1, the rotational movement inside the reagent / detector common storage unit 3, the drive and dispensing action of the dispensing mechanism 6, and the cleaning of the dispensing nozzle of the cleaning tank 7. It should be noted that in Figure 1 For the sake of simplicity, the connections between the various mechanisms constituting the automatic analysis device and the control unit 10 are omitted.

[0032] Figure 2A The steps of a typical dispensing operation performed by the dispensing mechanism 6 are shown. Since the dispensing mechanism 6 continuously dispenses the test sample and reagent using the same dispensing nozzle, in a typical dispensing operation, the reagent is first drawn in to prevent the test sample from being mixed into the reagent container 4.

[0033] (A1) The dispensing mechanism 6 moves the dispensing nozzle 201 to the reagent container 4 of the reagent / detector common storage section 3 to draw a specified amount of reagent.

[0034] (A2) The dispensing mechanism 6 moves the dispensing nozzle 201 to the cleaning tank 7, and the cleaning tank 7 cleans the outside of the dispensing nozzle 201 (external washing).

[0035] (A3) The dispensing mechanism 6 moves the dispensing nozzle 201 to the test body container 5 of the reagent / test body common storage section 3 to attract a specified amount of test body.

[0036] (A4) The dispensing mechanism 6 moves the dispensing nozzle 201 onto the reaction vessel 2 of the incubator 1, discharging the aspirated reagents and detectors into the reaction vessel 2. Through this dispensing action, the reagents and detectors are stirred and mixed. At this time, it is preferable to perform the action of aspirating the mixture of reagents and detectors in the reaction vessel 2 and dispensing it again more than once to mix the reagents and detectors more evenly.

[0037] (A5) The dispensing mechanism 6 moves the dispensing nozzle 201 to the cleaning tank 7, and the cleaning tank 7 cleans the outer and inner sides of the dispensing nozzle 201 (external washing and internal washing).

[0038] Figure 2B The steps of the dispensing mechanism 6 in avoiding contamination during dispensing are shown. Figure 2A In the normal dispensing operation shown, reagent adhering to the inside of the dispensing nozzle 201 may mix into the sample container 5 when the sample is aspirated. Therefore, for the sample contained in the sample container 5, if the mixing of reagent may adversely affect the analysis of subsequent test items, the control unit 10 performs a dispensing operation instead of the normal dispensing operation. Figure 2B The dispensing procedure shown is designed to prevent contamination. In this procedure, the dispensed test sample is temporarily transferred from the test sample container 5 to another container, and the dispensing is performed from that other container, thereby preventing reagents from entering the test sample container 5.

[0039] (B1) The dispensing mechanism 6 moves the dispensing nozzle 201 to the test body container 5 of the reagent / test body common storage section 3 and draws a specified amount of test body.

[0040] (B2) The dispensing mechanism 6 moves the dispensing nozzle 201 to the first reaction container 2a of the incubator 1 and discharges the attracted test sample into the first reaction container 2a.

[0041] (B3) The dispensing mechanism 6 moves the dispensing nozzle 201 to the cleaning tank 7, and the cleaning tank 7 cleans the outer and inner sides of the dispensing nozzle 201 (external washing and internal washing).

[0042] (B4) The dispensing mechanism 6 moves the dispensing nozzle 201 to the reagent container 4 of the reagent / detector common storage section 3 to draw a specified amount of reagent.

[0043] (B5) The dispensing mechanism 6 moves the dispensing nozzle 201 to the cleaning tank 7, and the cleaning tank 7 cleans the outside of the dispensing nozzle 201 (external washing).

[0044] (B6) The dispensing mechanism 6 moves the dispensing nozzle 201 to the first reaction container 2a of the incubator 1 and draws a predetermined amount of the test sample from the first reaction container 2a.

[0045] (B7) The dispensing mechanism 6 moves the dispensing nozzle 201 onto the second reaction container 2b of the incubator 1, discharging the attracted reagents and detectors into the second reaction container 2b. Through this dispensing action, the reagents and detectors are stirred and mixed. At this time, it is preferable to perform the action of attracting the mixture of reagents and detectors in the second reaction container 2b and dispensing it again more than once to mix the reagents and detectors more evenly.

[0046] (B8) The dispensing mechanism 6 moves the dispensing nozzle 201 to the cleaning tank 7, and the cleaning tank 7 cleans the outer and inner sides of the dispensing nozzle 201 (external washing and internal washing).

[0047] It should be noted that steps (B1) to (B8) do not need to be performed continuously; they can also be separated into a first sequence of steps (B1) to (B3) and a second sequence of steps (B4) to (B8). When separated into two sequences, the actions are as follows: In the cycle preceding the execution of the second sequence, the first sequence is executed, dispensing the detection body into the first reaction vessel 2a located at the access point of the dispensing nozzle (steps (B1) to (B3)). After a predetermined time (e.g., after several tens of seconds), the second sequence is executed at the point where both the first reaction vessel 2a and the second reaction vessel 2b are located at the access point of the dispensing nozzle (steps (B4) to (B8)).

[0048] In this dispensing process designed to avoid contamination, the test sample transferred from the test sample container 5 to the first reaction container 2a via step (B2) may become contaminated with reagents after step (B6). Therefore, it is not limited to using the remaining test sample for subsequent tests. Typically, since the test sample in the test sample container 5 is used for analyses related to multiple measurement items, it is desirable to minimize the amount of test sample dispensed from the test sample container 5 to the first reaction container 2a in steps (B1) to (B2) to ensure that the amount of test sample contained in the test sample container 5 is not insufficient. However, if the amount of test sample contained in the first reaction container 2a is small, the aspiration action of the test sample in step (B6) may be hindered.

[0049] Figure 3AThe diagram illustrates the action (first action) of the dispensing mechanism 6 drawing the detection medium from the reaction vessel 2. The first action is the standard suction action when the dispensing mechanism 6 draws liquid from the reaction vessel 2. State (S01) is the initial state, with the tip of the dispensing nozzle 201 positioned at a height h1 above the bottom surface of the reaction vessel 2. Since the bottom area of ​​the reaction vessel 2 is known, the height h2A of the liquid level in the reaction vessel 2 above the bottom surface can be calculated based on the amount of detection medium discharged in step (B2). State (S02) indicates the state where the dispensing nozzle 201 is lowered to the suction position. The descent amount of the dispensing nozzle 201 in the standard suction action is h1 - (h2A - ε). The insertion amount ε is preset by the device. If the insertion amount ε of the tip of the dispensing nozzle 201 into the detection medium is too small, due to the surface tension of the detection medium, shaking, or installation tolerances of the dispensing nozzle or reaction vessel, a deviation may occur between the calculated liquid level height and the actual liquid level height, potentially leading to malfunctions such as air entrapment during the suction of the detection medium. On the other hand, if the inrush amount ε is too large, it will result in a larger cleaning range (external washing) of the dispensing nozzle 201. Therefore, although it is required to be as short as possible, the inrush amount ε is set to a length that allows for stable suction action (state (S03)). Thus, for example, if the amount of detector discharged into the first reaction vessel 2a in step (B2) is set to be less than or equal to the liquid level height ε, then in step (B6), suction of the detector based on the standard suction action cannot be performed.

[0050] Therefore, in this embodiment, a second action (small-volume suction action) is set to draw liquid from the reaction vessel 2. This second action can be performed even if the amount of the detection substance dispensed into the first reaction vessel 2a is set to a dispensing amount where the liquid level is below ε. When the amount of the detection substance dispensed into the first reaction vessel 2a is below a predetermined threshold, the suction action in step (B6) is applied... Figure 3B The small amount of attraction shown.

[0051] State (S11) is the initial state, with the tip of the dispensing nozzle 201 positioned at a height h1 above the bottom surface of the reaction vessel 2, and the liquid level in the reaction vessel 2 at a height h2B above the bottom surface. Next, the dispensing nozzle 201 descends until its tip reaches the bottom of the reaction vessel 2 (state (S12)). Then, the dispensing nozzle 201 is raised only a certain distance δ (δ < ε) (state (S13)). The detector is attracted while the tip of the dispensing nozzle 201 is at a height δ above the bottom surface of the reaction vessel 2 (state (S14)).

[0052] The injection rate ε set in the standard suction operation is configured to allow for stable suction of the reaction solution containing the detector and pretreatment solution, or of diluted detector obtained by diluting the detector with a diluent. In contrast, in step (B6), the detector itself is contained in the reaction vessel 2. Therefore, in step (B6), both the amount of liquid contained in the reaction vessel 2 and the amount of liquid suctioned by the dispensing nozzle are significantly less than what is expected in the standard suction operation. Consequently, if the detector is dispensed from the detector container 5 into the first reaction vessel 2a to the extent that a standard suction operation can be performed, the amount of discarded detector increases. By setting a small suction operation, a stable suction operation can be performed even when only a small amount of detector is contained in the reaction vessel 2, thus suppressing the amount of discarded detector.

[0053] Control unit 10 determines that the betting action performed by betting mechanism 6 is set as Figure 2A The usual betting action, or set as Figure 2B To avoid contamination during dispensing. The control unit 10 determines, based on the measurement request information for the sample, whether there is a possibility that the contamination of reagents may adversely affect the analysis of subsequent measurement items. Figure 4 The measurement request information data 401 input into the automated analyzer is shown. The measurement request information data 401 includes analyte category information 402 and measurement item information 403. The analyte category information 402 indicates the category of the analyte, such as serum, plasma, or urine. The measurement item information 403 indicates the measurement items related to the analyte, thereby determining the reagents used for the measurement.

[0054] The control unit 10 has a decision table 501 for selecting the dispensing action based on the test subject category information 402, the test item information 403, or a combination of the test subject category information 402 and the test item information 403 in the test commission information data 401. Figure 5A This is an example of a decision table 501a that selects the dispensing action based on the analyte category information. As an example that could potentially adversely affect the analysis, the protein content of the reagent can be considered. For instance, if the analyte originally contains a large amount of protein, it can be said that the analytical results will not change due to the contamination of trace amounts of reagent. Therefore, decision table 501a establishes a correspondence between the analyte category and the application of dispensing actions to avoid contamination. Similarly, when selecting the dispensing action based on the measurement item information, the control unit 10 maintains the decision table 501a, changing the analyte category column to the measurement item column.

[0055] Figure 5BThis is an example of decision table 501b, which selects dispensing actions based on a combination of analyte category information and assay item information. Depending on the assay item, there are also cases where only reagents that will not affect the analytical results even if mixed in may be used. By using decision table 501b, dispensing actions that avoid contamination can be implemented by limiting the selection to combinations of analyte categories and assay items that may affect the assay results.

[0056] The embodiments of the present invention have been described above, but the present invention is not limited to the above embodiments and includes various modifications. The following describes examples of modifications.

[0057] (Variation Example 1)

[0058] If the test sample remains after being dispensed into the first reaction vessel 2a, it needs to be discarded if it affects the test results. However, if it does not affect the test results, the test sample remaining after being dispensed into the first reaction vessel 2a can be used continuously to perform other tests.

[0059] (Variation Example 2)

[0060] In the embodiments, examples are shown of applications that determine the dispensing action to avoid contamination by detecting body category information, measurement item information, or a combination of body category information and measurement item information. However, applications that determine the dispensing action to avoid contamination can also be determined based on other information, such as the status of the automatic analysis device.

[0061] For example, in situations where the operator has not performed nozzle maintenance, or where the sample type is susceptible to contamination from reagents, a dispensing procedure to avoid carrying over contamination should be applied. Since the lack of nozzle maintenance creates a risk of contamination, a dispensing procedure to avoid contamination from nozzle dirt should be applied. The performance of nozzle maintenance can be determined from the device's operation log.

[0062] Alternatively, even if the QC measurement is performed directly despite the result being outside the reference range, a dispensing operation to avoid carrying over contaminants should be applied regardless of the type of test sample. As a reason the QC measurement result may be outside the reference range, dirt may accumulate on the dispensing nozzle. Therefore, to prevent contamination caused by dirt on the dispensing nozzle, a dispensing operation to avoid carrying over contaminants should be applied.

[0063] The above embodiments or variations are examples provided for easy understanding and illustration of the present invention, and are not limited to having all the structures described. For example, although an example is shown of a reaction vessel 2b in which the test substance is temporarily dispensed onto the culture vessel 1 during a dispensing operation to avoid contamination, it may also be held on the holding part if there is a holding part for temporarily holding the dispensed test substance.

[0064] Explanation of reference numerals in the attached figures:

[0065] 1: Incubator, 2: Reaction vessel, 3: Reagent / detector shared storage unit, 4: Reagent container, 4b: Reagent bottle, 5: Detector container, 6: Dispensing mechanism, 7: Cleaning tank, 8: Spectrophotometer, 10: Control unit, 201: Dispensing nozzle, 401: Measurement commission information data, 402: Detector category information, 403: Measurement item information, 501: Judgment table.

Claims

1. An automatic analysis device, wherein, The automatic analysis device has the following features: The dispensing mechanism has a dispensing nozzle to dispense the test sample or reagent into the reaction vessel; A cleaning tank is used to clean the dispensing nozzle; and The control unit controls the dispensing mechanism and the cleaning tank by dispensing the test sample and reagent into the reaction vessel through a first dispensing action or a second dispensing action. The first betting action includes: In the first step, the dispensing mechanism uses the dispensing nozzle to draw the reagent contained in the reagent container; The second step, after the first step, is to clean the outside of the dispensing nozzle using the cleaning tank. The third step, following the second step, involves the dispensing mechanism using the dispensing nozzle to draw in the test body contained in the test body container; and In the fourth step, following the third step, the dispensing mechanism discharges the reagents and detectors attracted in the first and third steps into the reaction vessel. The second betting action includes: In the first step, the dispensing mechanism uses the dispensing nozzle to attract the detection body contained in the detection body container; The second step, following the first step, is that the dispensing mechanism discharges the sample attracted in the first step into the first reaction vessel. The third step, after the second step, is to clean the inside and outside of the dispensing nozzle using the cleaning tank. The fourth step, after the third step, is that the dispensing mechanism uses the dispensing nozzle to draw the reagent contained in the reagent container; The fifth step, after the fourth step, is to clean the outside of the dispensing nozzle using the cleaning tank. The sixth step, following the fifth step, involves the dispensing mechanism using the dispensing nozzle to draw in the detector contained within the first reaction vessel; and In the seventh step, following the sixth step, the dispensing mechanism discharges the reagents and detectors attracted in the fourth and sixth steps into the second reaction vessel. The control unit determines whether to perform the first dispensing action or the second dispensing action based on the measurement request information data of the test subject, depending on whether the mixing of the reagent into the test subject container will affect the analysis of the measurement items included in the measurement request of the test subject.

2. The automatic analysis device according to claim 1, wherein, In the fourth step of the first dispensing action, the dispensing mechanism performs one or more actions of aspirating the mixture of reagent and detector in the reaction vessel and discharging it again. In the seventh step of the second dispensing action, the dispensing mechanism performs an action of aspirating the mixture of reagent and detector in the second reaction vessel and discharging it again more than once.

3. The automatic analysis device according to claim 1, wherein, In the sixth step of the second dispensing operation, if the amount of the detector sample attracted in the second step of the second dispensing operation is above a predetermined threshold, the dispensing mechanism lowers the dispensing nozzle so that the tip of the dispensing nozzle reaches a predetermined depth from the liquid surface of the first reaction container, and then uses the dispensing nozzle to attract the detector sample contained in the first reaction container.

4. The automatic analysis device according to claim 3, wherein, In the sixth step of the second dispensing action, if the amount of the detector sample attracted in the second step of the second dispensing action is lower than a predetermined threshold, the dispensing mechanism lowers the dispensing nozzle so that the tip of the dispensing nozzle reaches the bottom surface of the first reaction container, then raises the dispensing nozzle to a predetermined height, and then uses the dispensing nozzle to attract the detector sample contained in the first reaction container.

5. The automatic analysis device according to claim 1, wherein, The control unit executes the first to third steps of the second betting action as a series of first sequences, and executes the fourth to seventh steps of the second betting action as a series of second sequences after a predetermined time following the execution of the first sequence.

6. The automatic analysis device according to claim 5, wherein, The automatic analysis device has the following features: The incubator is driven to rotate by a drive mechanism and is circumferentially arranged with the reaction vessel used in the first dispensing action and a reaction vessel containing the first reaction vessel and the second reaction vessel used in the second dispensing action. as well as A spectrophotometer is used to perform biochemical analysis on the reaction solution of the test sample and reagents in the reaction vessel of the culture apparatus.

7. The automatic analysis device according to claim 1, wherein, The control unit determines whether to perform the first dispensing action or the second dispensing action based on the detector category information of the detector in the measurement commission information data of the detector.

8. The automatic analysis device according to claim 1, wherein, The control unit determines whether to perform the first dispensing action or the second dispensing action based on the measurement item information of the detection body in the measurement entrustment information data of the detection body.

9. The automatic analysis device according to claim 1, wherein, The control unit determines which of the first and second dispensing actions to perform based on the combination of the detector category information and the measurement item information in the measurement commission information data of the detector.

10. The automatic analysis device according to claim 1, wherein, The control unit determines whether to perform the first dispensing action or the second dispensing action based on the status of the automatic analysis device, depending on whether the device status is such that the mixing of the reagent into the detection container is likely to affect the analysis of the detection.

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