A cell-gel material composite gel microsphere and its preparation method and application
By preparing cell-gel material composite gel microspheres, the problem of traditional methods being unable to effectively regulate inflammation was solved, and low-cost and efficient wound healing effects were achieved. Paracrine cells were used to supply cytokines in real time in a three-dimensional structure to promote anti-inflammatory and repair functions.
Patent Information
- Application Number
- CN202211621884.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2022-12-16
- Publication Date
- 2025-09-23
- Estimated Expiration
- 2042-12-16
AI Technical Summary
Existing technologies cannot effectively regulate inflammatory responses when treating trauma, traditional methods cannot meet the diverse needs of wound healing, and growth factors are expensive.
Cell-gel material composite gel microspheres are used, with paracrine cells inside and a gelatin and sodium alginate composite hydrogel wrapped on the outside. Injectable microspheres are prepared through emulsification and ionic cross-linking to simulate the three-dimensional structure of the extracellular matrix, load paracrine cells to supply cytokines in real time to regulate inflammation.
It provides a growth environment similar to that in the body, promotes cell vitality and paracrine function, enhances anti-inflammatory effects, and promotes wound healing. The material source is abundant and the price is low. Cells survive for a long time in the microspheres, and the three-dimensional structure is conducive to the growth of fibroblasts.
Smart Images
Figure CN116440098B_ABST