Light irradiation device

Abstract

Provided is a light irradiation device that can uniformly irradiate light to the entire cancer without deviation in the light emission amount of a light emission portion and can discharge bile even when the light emission portion is arranged in a manner that blocks a narrow portion. The light irradiation device (100) of the present application includes a tube (10) having a tube main body (11) and a light emission portion (13); a plurality of wiring boards (30) arranged inside the light emission portion (13) and arranged at equal intervals with a plurality of light emission elements (35) mounted thereon; an anode-side lead wire (51) for connecting an anode terminal (36) of each wiring board (30) to a power source; and a cathode-side lead wire (52) for connecting a cathode terminal (37) of each wiring board (30) to the power source, wherein a central cavity (101) and peripheral cavities (102-105) arranged at 90° intervals around the central cavity are formed in the light emission portion (13), and the wiring boards (30) are arranged in each peripheral cavity in a manner that the light emission elements (35) are arranged in the length direction of the light emission portion (13).

Description

TECHNICAL FIELD

[0001] The present application relates to a light irradiation device for irradiating light of a specific wavelength required in a light immunotherapy for a lesion. BACKGROUND

[0002] Recently, as a light irradiation device in which a light immunotherapy for cancer can be implemented relatively easily without using a large-scale device such as a laser oscillator, a light irradiation device (light emitting type treatment device) having a tube provided with a light-emitting portion of light-transmissive property at a tip end side, a flexible wiring substrate disposed inside the light-emitting portion of the tube and provided with a light-emitting element that irradiates light of a specific wavelength, a main body portion connected to a base end portion of the tube and provided with a power source for supplying electric power to the light-emitting element, and a lead wire inserted into the tube, one end of the lead wire being connected to an electrode of the flexible wiring substrate and the other end being connected to the power source (see the following Patent Literature 1) has been introduced.

[0003] In a case where a light immunotherapy is implemented for a bile duct cancer by such a light irradiation device, first, an endoscope (side-viewing endoscope) is inserted from a mouth of a patient and a tip end portion thereof is brought to a duodenal papilla portion, a tube is inserted into a bile duct along a guide wire that is previously inserted into the bile duct, and the light-emitting portion is disposed in contact with or in proximity to the bile duct cancer. Next, the guide wire and the endoscope are pulled out, and only the tube is left in the body. Thereafter, a base end portion of the tube that protrudes from the mouth is made to protrude from a nostril via a nasal cavity.

[0004] PRIOR ART DOCUMENTS

[0005] PATENT LITERATURE

[0006] Patent Literature 1: Japanese Patent Application Laid-Open No. 2020-43897 SUMMARY

[0007] PROBLEMS TO BE SOLVED BY THE INVENTION

[0008] In a light immunotherapy for a bile duct cancer, it is desirable to uniformly irradiate light to the entire bile duct cancer generated on an inner wall of the bile duct.

[0009] However, in the conventional light irradiation device, there is a deviation in the amount of light emission (amount of light irradiation to cancer) from the light-emitting portion.

[0010] For example, in the light irradiation device disclosed in the above-described Patent Literature 1, a flexible wiring substrate is disposed inside the light-emitting portion of the tube, the flexible wiring substrate being bent into a shape in which a pair of side portions are disposed in opposition to each other via a bent portion, and a plurality of light-emitting elements are mounted on each side portion, but in such a light irradiation device, a deviation in the amount of light emission occurs in the circumferential direction of the light-emitting portion.

[0011] Further, in the light irradiation device disclosed in the above-described Patent Document 1, the light emitting portion of the tube is provided with a flexible wiring substrate having a shape twisted into a spiral shape and a plurality of light emitting elements mounted on an outer surface thereof, but in such a light irradiation device, the light emission amount also deviates in the length direction of the light emitting portion.

[0012] In photodynamic therapy for bile duct cancer, it is necessary to position the light emitting portion of the light irradiation device at the bile duct cancer that narrows the bile duct and irradiate light for a long time (about two weeks or so).

[0013] However, when light is irradiated to the bile duct cancer, the light emitting portion of the light irradiation device blocks the bile duct narrowed by the bile duct cancer, and therefore bile accumulates in the gallbladder, and the patient sometimes develops jaundice.

[0014] The present application is an application completed based on the above-described situation.

[0015] An object of the present application is to provide a light irradiation device that can uniformly irradiate light of a specific wavelength to a cancer generated on the inner wall of a body tube in the circumferential direction of the body tube without deviation of the light emission amount in the circumferential direction of the light emitting portion.

[0016] Another object of the present application is to provide a light irradiation device that can uniformly irradiate light of a specific wavelength to a cancer generated on the inner wall of a body tube as a whole without deviation of the light emission amount in the circumferential direction and the length direction of the light emitting portion.

[0017] Still another object of the present application is to provide a light irradiation device that can perform drainage (drainage) of a body fluid even when the light emitting portion is arranged in a manner of blocking a stenosis site caused by a cancer in photodynamic therapy.

[0018] Technical Solution

[0019] (1) The light irradiation device of the present application for irradiating light of a specific wavelength required in photodynamic therapy to a lesion (cancer) is characterized by comprising:

[0020] a tube having a tube main body and a light-transmissive light emitting portion connected to the top end side of the tube main body;

[0021] a plurality of wiring substrates arranged inside the light emitting portion of the tube and mounted with light emitting elements that emit light of the specific wavelength;

[0022] an anode-side lead extending inside the tube to connect an anode terminal of each of the wiring substrates to a power source; and

[0023] a cathode-side lead extending inside the tube to connect a cathode terminal of each of the wiring substrates to the power source,

[0024] A central cavity extending along the center axis of the tube and a plurality of peripheral cavities arranged at equal angular intervals around the central cavity (i.e., in the circumferential direction of the light emitting portion) are formed in the light emitting portion, the plurality of peripheral cavities being closed at the top end side of the light emitting portion,

[0025] The wiring substrate is arranged in each of the peripheral cavities in a manner such that the light emitting elements are arranged outside in the radial direction toward the light emitting portion.

[0026] According to the light irradiation device thus configured, the photoimmunotherapy treatment of cancer can be performed in the following manner: the tube is inserted into the body, the light emitting portion is arranged in contact with or in the vicinity of a lesion (cancer) to which a photosensitive substance for photoimmunotherapy is attached, the plurality of wiring substrates are energized through the anode-side lead and the cathode-side lead, the light emitting elements mounted to the wiring substrates are caused to emit light, and the light is irradiated to the photosensitive substance or the like attached to the cancer.

[0027] Further, the wiring substrates on which the light emitting elements are mounted are arranged in each of the plurality of peripheral cavities arranged at equal angular intervals around the central cavity of the light emitting portion, whereby the light of a specific wavelength can be emitted in a radial pattern without deviation in the circumferential direction of the light emitting portion, and the light can be uniformly irradiated to the lesion (photosensitive substance attached to cancer or the like) around the light emitting portion.

[0028] Furthermore, even if the light emitting portion is arranged in a manner such that a narrow portion of a body tube through which a body fluid such as bile flows is plugged, the body fluid can be discharged to the outside of the body by causing the body fluid to flow in the central cavity of the light emitting portion. Further, by causing the body fluid to flow in the central cavity, the light emitted from the light emitting elements mounted to the wiring substrates arranged in each of the peripheral cavities is not blocked by the body fluid.

[0029] (2) In the light irradiation device of the present application, it is preferable that each of the wiring substrates on which a plurality of the light emitting elements are mounted be arranged at substantially equal intervals,

[0030] The wiring substrate is arranged in each of the peripheral cavities in a manner such that the plurality of light emitting elements are arranged in the length direction of the light emitting portion outside in the radial direction toward the light emitting portion.

[0031] According to the light irradiation device thus configured, the wiring substrates are arranged in each of the plurality of peripheral cavities arranged at equal angular intervals around the central cavity of the light emitting portion in a manner such that the light emitting elements are arranged in the length direction of the light emitting portion, whereby the light of a specific wavelength can be emitted in a radial pattern without deviation in the circumferential direction and the length direction of the light emitting portion, and the light can be uniformly irradiated to the lesion (photosensitive substance attached to cancer or the like) around the light emitting portion as a whole.

[0032] (3) In the light irradiation device of the present application, it is preferable that four peripheral cavities be formed at 90° intervals around the central cavity.

[0033] According to the light irradiation device configured as such, four wiring substrates can be arranged in the circumferential direction of the light emitting portion, and thus light can be uniformly irradiated to the entire affected portion around the light emitting portion without unevenness.

[0034] (4) In the light irradiation device of the present application, it is preferable that a first cavity and a second cavity are formed in the tube main body of the tube, the first cavity communicates with the central cavity of the light emitting portion, the first cavity is displaced from the central axis of the tube in the radial direction of the tube and extends in parallel with the central axis, the second cavity extends in parallel with the first cavity and opens at the base end surface of the tube,

[0035] The anode-side lead and the cathode-side lead are inserted from each of the peripheral cavities into the second cavity, extend along the second cavity, and protrude from the opening of the base end surface.

[0036] According to the light irradiation device configured as such, in the tube main body, the anode-side lead and the cathode-side lead can extend along the second cavity, and the patient's body fluid can flow in the first cavity, and thus the patient's body fluid does not come into contact with the anode-side lead and the cathode-side lead inside the tube main body, and short circuit between the leads, contamination of the leads, and the like caused by contact with the body fluid can be avoided.

[0037] Further, the first cavity is displaced from the central axis of the tube in the radial direction of the tube, and thus the cross-sectional area of the second cavity, which is a lead insertion space, can be sufficiently ensured, and the light irradiation device of the following (7) can be configured to discharge the patient's body fluid flowing in the first cavity from the side peripheral surface of the tube main body.

[0038] (5) In the light irradiation device of the above (4), it is preferable that the tube has a cavity switching portion between the light emitting portion and the tube main body, the cavity switching portion seals the anode-side lead and the cathode-side lead, and a communication path that communicates the central cavity and the first cavity is formed.

[0039] According to the light irradiation device configured as such, the central cavity of the light emitting portion and the first cavity of the tube main body can be reliably communicated through the communication path of the cavity switching portion.

[0040] Further, the anode-side lead and the cathode-side lead are sealed in the cavity switching portion (fixed by the constituting resin of the cavity switching portion), and thus when the base end portions of the leads are connected to a power source or the like, the leads can be reliably prevented from being pulled in the base end direction so that the tip end portions of the leads are detached from the electrode terminals of the wiring substrates or the leads are prevented from being entangled in the cavity switching portion.

[0041] (6) In the light irradiation device according to (4) or (5) above, it is preferable that a plurality of the anode-side lead wires and a plurality of the cathode-side lead wires inserted into the second lumen are each gathered into one and extended from the opening of the base end surface of the tube.

[0042] According to the light irradiation device thus configured, the anode-side lead wires and the cathode-side lead wires are each aggregated into one, so that the operation of connecting the base end portions of these lead wires to a power source can be simplified.

[0043] (7) In the light irradiation device according to (4) to (6) above, it is preferable that the first lumen is closed at the base end side of the tube, and a side hole from the outer peripheral surface of the tube main body to the first lumen is formed in the peripheral wall of the tube main body.

[0044] According to the light irradiation device thus configured, the body fluid of the patient flowing in the first lumen can be discharged from the opening of the side hole (using the opening as a drain), so that the anode-side lead wires and the cathode-side lead wires extended from the opening of the base end surface of the tube can be prevented from coming into contact with the discharged body fluid.

[0045] (8) In the light irradiation device according to (7) above, a mark indicating the position of the opening of the side hole is applied to the outer peripheral surface of the tube main body, which is preferable because the position of the small-diameter opening can be easily recognized.

[0046] (9) In the light irradiation device of the present application, it is preferable that a lead wire protection cover is attached to the base end side of the tube, the lead wire protection cover encloses the anode-side lead wires and the cathode-side lead wires extended from the opening of the base end surface of the tube, and can be easily detached from the tube.

[0047] According to the light irradiation device thus configured, when the base end portion of the tube extended from the mouth is extended from the nostril via the nasal cavity, the lead wires (anode-side lead wires and cathode-side lead wires) extended from the opening of the base end surface of the tube can be prevented from being wetted by nasal mucus or the like. Also, after the base end portion of the tube is extended from the nostril of the patient, by detaching the lead wire protection cover from the tube, the base end portions of the lead wires in a state not wetted can be connected to a power source.

[0048] (10) In the light irradiation device of the present application, it is preferable that the tube has a single-lumen-structured topmost end portion at the top end side of the light emitting portion, and the topmost end portion is formed with a lumen communicating with the central lumen.

[0049] According to the light irradiation device thus configured, the body fluid of the top end side of the light emitting portion disposed in a manner of plugging a narrow portion can be caused to flow in the central lumen of the light emitting portion via the lumen of the topmost end portion and discharged to the outside of the body.

[0050] (11) In the light irradiation device of the above (10), it is preferable that at least one side hole be formed in the peripheral wall of the topmost end portion from the outer peripheral surface of the topmost end portion to the cavity.

[0051] According to the light irradiation device thus configured, even in a case where the opening at the top end of the topmost end portion abuts against the inner wall of the body tube or the like so that the body fluid cannot flow from the opening into the cavity, the body fluid can flow from the side hole.

[0052] (12) In the light irradiation device of the above (10) or (11), it is preferable that the diameter of the cavity of the topmost end portion be larger than the diameter of the central cavity of the light emitting portion,

[0053] The tube has a cavity expansion portion between the light emitting portion and the topmost end portion, and the cavity expansion portion is formed with an expansion communication path that communicates the central cavity and the cavity of the topmost end portion.

[0054] According to the light irradiation device thus configured, the inflow amount of the body fluid into the cavity of the topmost end portion can be sufficiently ensured, and further the outflow amount of the body fluid can be sufficiently ensured.

[0055] (13) The light irradiation device of the present application can be appropriately used for photoimmunotherapy of cholangiocarcinoma or pancreatic cancer.

[0056] According to the light irradiation device thus configured, the cholangiocarcinoma generated on the inner wall of the bile duct and the pancreatic cancer generated on the inner wall of the pancreatic duct can be uniformly irradiated with light of a specific wavelength in the circumferential direction of the bile duct and the pancreatic duct, and the outflow of bile can be performed even if the light emitting portion is arranged in a manner of plugging the stenosis site caused by cholangiocarcinoma or pancreatic cancer.

[0057] Effects of the Invention

[0058] According to the light irradiation device of the present application, light of a specific wavelength can be uniformly irradiated to cancer generated on the inner wall of a body tube in the circumferential direction of the body tube without deviation in the light emission amount in the circumferential direction of the light emitting portion.

[0059] Further, the wiring substrates are arranged in each of the peripheral cavities in a manner that the plurality of light emitting elements are arranged in the length direction of the light emitting portion in a state of being outside in the radial direction toward the light emitting portion, whereby light of a specific wavelength can be uniformly irradiated to cancer generated on the inner wall of a body tube as a whole without deviation in the light emission amount in the circumferential direction and the length direction of the light emitting portion.

[0060] Further, even in a case where the light emitting portion is arranged in a manner of plugging the stenosis site of the body tube, the outflow (drainage) of the body fluid can be performed by making the body fluid flow in the central cavity of the light emitting portion.

[0061] Furthermore, by allowing bodily fluid to circulate within the central cavity, the light emitted from the light-emitting element mounted on the wiring substrate will not be blocked by the bodily fluid, and the amount of light emitted by the light-emitting part will not be reduced due to being blocked by the bodily fluid. Attached Figure Description

[0062] Figure 1 This is a top view showing one embodiment of the light irradiation device of the present invention.

[0063] Figure 2A yes Figure 1 IIA-IIA sectional view (topmost sectional view).

[0064] Figure 2B yes Figure 1 IIB-IIB sectional view (sectional view of the light-emitting part).

[0065] Figure 2C yes Figure 1 IIC-IIC sectional view (sectional view of the light-emitting part).

[0066] Figure 2D yes Figure 1 IID-IID sectional view (sectional view of the pipe body).

[0067] Figure 2E yes Figure 1 IIE-IIE sectional view (sectional view of the tube body and lead wire protective sleeve).

[0068] Figure 2F yes Figure 1 IIF-IIF sectional view (sectional view of lead wire protective sleeve).

[0069] Figure 2G yes Figure 1 Detailed diagram of the IIG section.

[0070] Figure 3 It means in Figure 1 A perspective view of the light irradiation device shown, in which the leads extending from the peripheral cavities of the light-emitting part are inserted into the second cavity of the tube body.

[0071] Figure 4A Observed from the basal side Figure 1 The diagram shows a three-dimensional view of the light irradiation device, in which leads extending from the peripheral cavities of the light-emitting part are inserted into the second cavity of the tube body.

[0072] Figure 4B Viewed from the top side Figure 1 The diagram shows a three-dimensional view of the light irradiation device, in which leads extending from the peripheral cavities of the light-emitting part are inserted into the second cavity of the tube body.

[0073] Figure 5 yesFigure 1 a schematic view of a light irradiation device.

[0074] Figure 6 a schematic view of a power supply device for connection of lead wires of a light irradiation device.

[0075] Figure 7A a schematic view of a wiring substrate constituting Figure 1 a plan view of a wiring substrate of a light irradiation device.

[0076] Figure 7B a schematic view of a wiring substrate constituting Figure 1 a side view of a wiring substrate of a light irradiation device. DETAILED DESCRIPTION

[0077] <EMBODIMENT>

[0078] Figures 1-5 The light irradiation device 100 of the present embodiment shown in the figure is used for irradiation of near-infrared light required in a photoimmunotherapy of cholangiocarcinoma with light to cholangiocarcinoma, wherein the light irradiation device is provided with:

[0079] a tube 10 having a tube main body 11, a light-transmissive light emitting portion 13 connected to the top end side of the tube main body 11 via a lumen switching portion 12, and a topmost end portion 15 connected to the top end side of the light emitting portion 13 via a lumen expanding portion 14;

[0080] four wiring substrates 30 disposed inside the light emitting portion 13 of the tube 10, and seven light emitting elements 35 emitting near-infrared light mounted at equal intervals;

[0081] four anode-side lead wires 51 extending inside the tube 10 to connect the anode terminals 36 of the respective wiring substrates 30 to a power supply;

[0082] four cathode-side lead wires 52 extending inside the tube 10 to connect the cathode terminals 37 of the respective wiring substrates 30 to the power supply; and

[0083] a lead wire protection cover 70 attached to the base end side of the tube 10,

[0084] a central lumen 131 extending along the central axis of the tube 10 and peripheral lumens 132 to 135 arranged at 90° intervals around the central lumen 131 are formed in the light emitting portion 13 of the tube 10, and the peripheral lumens 132 to 135 are occluded at both end sides of the light emitting portion 13,

[0085] A first cavity 111 which communicates with the central cavity 131 formed in the light emitting portion 13 and which is displaced from the center axis of the tube 10 to the radial direction of the tube 10 and which extends, and a second cavity 112 which extends in parallel with the first cavity 111 are formed in the tube body 11 of the tube 10,

[0086] The first cavity 111 is closed at the base end side of the tube body 11, and a side hole 113 from the outer peripheral surface of the tube body 11 to the first cavity 111 is formed in the peripheral wall of the tube body 11,

[0087] The second cavity 112 is closed at the top end side of the tube body 11, and an opening 114 is provided in the base end surface of the tube 10,

[0088] A cavity 151 having a diameter larger than that of the central cavity 131 of the light emitting portion 13 is formed in the topmost end portion 15 of the tube 10, and the cavity 151 communicates with the central cavity 131 via the diameter-enlarged communication path 141 of the cavity diameter-enlarged portion 14,

[0089] The cavity 151 of the topmost end portion 15 has an opening 152 in the top end surface of the tube 10, and a plurality of side holes 153 from the outer peripheral surface of the topmost end portion 15 to the cavity 151 are formed in the peripheral wall of the topmost end portion 15,

[0090] The four wiring substrates 30 are arranged in the length direction of the light emitting portion 13 with the light emitting elements 35 arranged outside in the radial direction of the light emitting portion 13,

[0091] The four anode-side lead wires 51 are inserted into the second cavity 112 of the tube body 11 from the respective peripheral cavities 132 to 135 of the light emitting portion 13 through the inside of the cavity switching portion 12, extend along the second cavity 112, and are gathered into one at the middle of the second cavity 112 to become the aggregated lead wire 51G which is drawn out to the outside of the tube 10 from the opening 114,

[0092] The four cathode-side lead wires 52 are also inserted into the second cavity 112 of the tube body 11 from the respective peripheral cavities 132 to 135 of the light emitting portion 13 through the inside of the cavity switching portion 12, extend along the second cavity 112, and are gathered into one at the middle of the second cavity 112 to become the aggregated lead wire 52G which is drawn out to the outside of the tube 10 from the opening 114.

[0093] The lead wire protection cover 70 is attached so as to enclose the anode-side lead wire 51G and the cathode-side lead wire 52G drawn out from the opening 114 at the base end surface of the tube 10.

[0094] The light irradiation device 100 of the present embodiment is used for photodynamic therapy that performs treatment by making the light emitting portion 13 adhere to a bile duct cancer generated in the inner wall of a bile duct and irradiating a photosensitive light from the light emitting element 35 to a photosensitive substance selectively attached to a cancer tissue. Here, as the photosensitive substance, for example, IR700 can be cited.

[0095] The light irradiation device 100 of the present embodiment is provided with the tube 10, the four wiring boards 30, the four anode-side lead wires 51 (one aggregated lead wire 51G aggregated from them), the four cathode-side lead wires 52 (one aggregated lead wire 52G aggregated from them), and the lead wire protection cover 70.

[0096] As shown in Figs. 1 and 2, the tube 10 constituting the light irradiation device 100 is composed of, in order from the base end side toward the tip end side, the tube main body 11, the lumen switching portion 12, the light emitting portion 13, the lumen expanding portion 14, and the tip end portion 15. Figure 1 Figure 5 As shown in Figs. 1 and 2, the tube 10 constituting the light irradiation device 100 is composed of, in order from the base end side toward the tip end side, the tube main body 11, the lumen switching portion 12, the light emitting portion 13, the lumen expanding portion 14, and the tip end portion 15.

[0097] The outer diameter of the tube 10 is generally set to 1.5 mm to 15 mm, and if one preferred example is shown, it is 2.3 mm.

[0098] The length (effective length) of the tube 10 is generally set to 300 mm to 5000 mm, and if one preferred example is shown, it is 1500 mm.

[0099] The light emitting portion 13 of the tube 10 has light transmissivity, and the central lumen 131 and the four peripheral lumina 132 to 135 are formed in the light emitting portion 13, in which the four peripheral lumina 132 to 135 are arranged at 90° intervals in the circumferential direction of the light emitting portion 13 around the central lumen 131.

[0100] As shown in Figs. 1 and 2, the tube 10 constituting the light irradiation device 100 is composed of, in order from the base end side toward the tip end side, the tube main body 11, the lumen switching portion 12, the light emitting portion 13, the lumen expanding portion 14, and the tip end portion 15. Figure 2B Figure 2C Figure 3 Figure 4A As shown in Figs. 1 and 2, the tube 10 constituting the light irradiation device 100 is composed of, in order from the base end side toward the tip end side, the tube main body 11, the lumen switching portion 12, the light emitting portion 13, the lumen expanding portion 14, and the tip end portion 15.

[0101] The central lumen 131 is a through lumen of the bile in the light emitting portion 13, and is open at the tip end side and the base end side of the light emitting portion 13.

[0102] The diameter of the central lumen 131 is generally set to 0.1 mm to 13 mm, and if one preferred example is shown, it is 0.7 mm.

[0103] The peripheral lumina 132 to 135 have a rectangular cross section with rounded corners (curves). The peripheral lumina 132 to 135 are lumina for accommodating the wiring boards 30, and are closed at the base end side of the light emitting portion 13 by the resin constituting the lumen switching portion 12 and at the tip end side of the light emitting portion 13 by the resin constituting the lumen expanding portion 14.​​​​

[0104] The cross-sectional dimensions (longitudinal × transverse) of the peripheral cavities 132 to 135 are typically set to (0.3mm × 0.3mm) to (3mm × 3mm), and if a preferred example is shown, it is (0.6mm × 0.9mm).

[0105] The length of the light-emitting part 13 is usually set to 3mm to 500mm, and in a preferred example, it is 40mm.

[0106] The light-emitting part 13 is made of a light-transmitting material. Examples of such materials include epoxy resin, polycarbonate, acrylic resin, ABS (Acrylonitrile Butadiene Styrene) resin, silicone resin, polyurethane resin, and other transparent resin materials.

[0107] The tube body 11 of tube 10 is connected to the base end of light-emitting part 13 via cavity switching part 12.

[0108] The tube body 11 has a first cavity 111 and a second cavity 112.

[0109] like Figure 2D , Figure 2E , Figure 3 as well as Figure 4B As shown, the first cavity 111 has a circular cross-section, and the first cavity 111 is displaced in the radial direction from the center axis of the tube 10 and extends parallel to the central axis.

[0110] The first cavity 111 is the bile flow cavity in the tube body 11. It is opened at the top end of the tube body 11 and is connected to the central cavity 131 of the light-emitting part 13 via the connecting passage 121 formed in the cavity switching part 12.

[0111] The diameter of the first cavity 111 is typically set to 0.4 mm to 13 mm, and in a preferred example, it is 0.85 mm.

[0112] The first cavity 111 is blocked at the base end of the tube body 11, so that the bile flowing in the first cavity 111 will not be discharged from the base end face of the tube 10.

[0113] Therefore, as a drainage path for bile flowing in the first cavity 111, a side hole 113 is formed on the peripheral wall of the tube body 11, extending from the outer peripheral surface of the tube body 11 to the first cavity 111. The opening of the side hole 113 in the outer peripheral surface of the tube body 11 becomes the outlet for bile flowing in the first cavity 111.

[0114] The opening shape of the side hole 113 is, for example, set to a capsule shape (ellipse), and if a preferred example of the opening size (minor axis × major axis) is shown, it is 0.8 mm × 10 mm.

[0115] Note that, in order for the operator to easily grasp the position of the opening of such a small path, it is preferable that a mark indicating the opening position be applied to the outer peripheral surface of the tube main body 11, such as by previously applying paint or the like around the opening.

[0116] The second cavity 112 has a capsule shape (elliptical shape) in cross section, and extends in parallel with the central axis of the tube 10 and the first cavity 111, displaced in the radial direction from the central axis (in a direction opposite to the direction in which the first cavity 111 is displaced).

[0117] The second cavity 112 is closed by the resin constituting the cavity switching portion 12 on the tip end side of the tube main body 11.

[0118] The second cavity 112 is open on the base end side of the tube main body 11, and has an opening 114 on the base end surface of the tube 10 (tube main body 11).

[0119] The second cavity 112 is a cavity for the lead wires (anode-side lead wire 51, polymerized lead wire 51G, cathode-side lead wire 52, polymerized lead wire 52G) to pass through.

[0120] The cross-sectional dimension (minor axis x major axis) of the second cavity 112 is generally set to (0.3 mm x 0.3 mm) to (5 mm x 5 mm), and if one preferred example is shown, it is (0.7 mm x 1.1 mm).

[0121] The length of the tube main body 11 is generally set to 500 mm to 4960 mm, and if one preferred example is shown, it is 1400 mm.

[0122] The tube main body 11 is composed of a resin. As the resin material, PEBAX (polyether block polyamide), polyurethane, polyamide, polyethylene, polypropylene, and the like can be cited.

[0123] The cavity switching portion 12 of the tube 10 is interposed between the light emitting portion 13 and the tube main body 11.

[0124] A communication path 121 is formed in the cavity switching portion 12, which communicates the central cavity 131 of the light emitting portion 13 and the first cavity 111 of the tube main body 11, to serve as a passage for the bile.

[0125] The length of the cavity switching portion 12 is generally set to 1 mm to 100 mm, and if one preferred example is shown, it is 10 mm.

[0126] The cavity switching portion 12 is composed of a resin, and the base end of the peripheral cavities 132 to 135 of the light emitting portion 13 and the tip end of the second cavity 112 of the tube main body 11 are closed by the resin constituting the cavity switching portion 12.

[0127] As the resin material constituting the cavity switching portion 12, the resin exemplified as the resin constituting the tube main body 11 can be cited.

[0128] The topmost end portion 15 of the tube 10 is connected to the top end side of the light emitting portion 13 via the cavity expanding portion 14.

[0129] In this topmost end portion 15, a cavity 151 is formed.

[0130] As shown in Figure 2A , the cavity 151 has a circular cross section, and extends along the central axis of the tube 10.

[0131] The cavity 151 is open on the base end side of the topmost end portion 15, and communicates with the central cavity 131 of the light emitting portion 13 via the expanding communication path 141 formed in the cavity expanding portion 14.

[0132] The cavity 151 is also open on the top end side of the topmost end portion 15, and has an opening 152 at the top end of the tube 10.

[0133] Further, a plurality of side holes 153 from the outer peripheral surface of the topmost end portion 15 to the cavity 151 are formed in the peripheral wall of the topmost end portion 15.

[0134] The topmost end portion 15 of the tube 10 is a drainage tube for flowing the bile accumulated on the top end side of the light emitting portion 13 into the cavity 151 to discharge it to the outside of the body, and the openings of the opening 152 and the side holes 153 are the flow inlets of the bile.

[0135] The diameter of the cavity 151 is larger than that of the central cavity 131, and is usually set to 0.5 mm to 14 mm, and if one preferred example is shown, it is 1.7 mm.

[0136] By this, the inflow amount of the bile into the cavity 151 can be sufficiently ensured, and further the discharge amount of the bile can be sufficiently ensured.

[0137] As shown in Figure 1 , the topmost end portion 15 remembers a shape bent in a J shape. If an external force is applied, this bent shape is easily deformed (for example, deformed into a straight line shape), but if the external force is removed, it returns to this bent shape. With this topmost end portion 15 of the bent shape, it can be engaged to the bile duct inner wall to arrange the light irradiation device 100 at a prescribed position.

[0138] Note that the means for facilitating the engagement of the topmost end portion (drainage tube) is of course not limited to this.

[0139] The length of the topmost end portion 15 is usually set to 10 mm to 100 mm, and if one preferred example is shown, it is 40 mm.

[0140] The cavity expanding portion 14 of the tube 10 is sandwiched between the light emitting portion 13 and the topmost end portion 15.

[0141] A diameter-enlarged communication passage 141 is formed in the cavity-enlarged portion 14 to communicate the central cavity 131 of the light-emitting portion 13 and the cavity 151 of the topmost portion 15, and serves as a passage for the flow of bile.

[0142] The diameter-enlarged communication passage 141 is a conical frustum-shaped space, and the diameter of the diameter-enlarged communication passage 141 at the base end of the cavity-enlarged portion 14 is the same as that of the central cavity 131, and the diameter of the diameter-enlarged communication passage 141 at the top end of the cavity-enlarged portion 14 is the same as that of the cavity 151.

[0143] The length of the diameter-enlarged communication passage 141 is generally set to 1 mm to 30 mm, and if one preferred example is shown, it is 10 mm.

[0144] The cavity-enlarged portion 14 is composed of resin, and the top ends of the peripheral cavities 132 to 135 of the light-emitting portion 13 are occluded by the resin that constitutes the cavity-enlarged portion 14.

[0145] As the resin material that constitutes the cavity-enlarged portion 14, the resin exemplified as the resin that constitutes the tube main body 11 can be exemplified.

[0146] In the case where the light-emitting portion 13 is disposed in a manner to block a stenosis portion of a bile duct, the bile of a patient accumulated around the topmost portion 15 flows into the cavity 151 from the opening 152 at the top end of the topmost portion 15 and the openings of the side holes 153.

[0147] The bile that flows into the cavity 151 of the topmost portion 15 flows through the cavity 151, the diameter-enlarged communication passage 141 of the cavity-enlarged portion 14, the central cavity 131 of the light-emitting portion 13, the communication passage 121 of the cavity switching portion 12, and the first cavity 111 of the tube main body 11, and is discharged to the outside of the body from the openings (discharge ports) of the side holes 113 formed in the peripheral wall of the tube main body 11.

[0148] As shown in Figs. 1 to 3, the tube 10 is provided with a light-emitting portion 13, a cavity switching portion 12, and a cavity-enlarged portion 14. Figure 2B , Figure 2C , Figure 3 and Figure 4A As shown in Figs. 1 to 3, the tube 10 is provided with a light-emitting portion 13, a cavity switching portion 12, and a cavity-enlarged portion 14.

[0149] As shown in Figs. 1 to 3, the tube 10 is provided with a light-emitting portion 13, a cavity switching portion 12, and a cavity-enlarged portion 14. Figure 7A and Figure 7B As shown in Figs. 1 to 3, the tube 10 is provided with a light-emitting portion 13, a cavity switching portion 12, and a cavity-enlarged portion 14.

[0150] On one face of the wiring substrate 30, seven light-emitting elements 35 composed of LEDs (Light-Emitting Diode) that emit near-infrared light (for example, with a wavelength of 680 nm to 700 nm) are mounted by being disposed at equal intervals along the length direction of the wiring substrate 30.

[0151] The anode terminal 36 and the cathode terminal 37 are arranged on the base end side of the wiring substrate 30.

[0152] The length of the wiring substrate 30 is generally set to 3 mm to 450 mm, and if one preferred example is shown, it is 40 mm.

[0153] The width of the wiring substrate 30 is generally set to 0.3 mm to 12.5 mm, and if one preferred example is shown, it is 0.55 mm.

[0154] The length of the mounting region of the light emitting element 35 (L35) is generally set to 5 mm to 455 mm, and if one preferred example is shown, it is 30 mm. Figure 7A

[0155] The wiring substrate 30 is arranged in a manner that the mounted light emitting element 35 is arranged in the length direction of the light emitting portion 13 in a state of being outside in the radial direction toward the light emitting portion 13 in each of the peripheral cavities 132 to 135.

[0156] Thus, since the four wiring substrates 30 are arranged at 90° intervals in the circumferential direction of the light emitting portion 13 and the seven light emitting elements 35 are arranged at equal intervals in the length direction of the light emitting portion 13 in each of the wiring substrates 30, the near-infrared light from the light emitting elements 35 can be emitted radially without deviation in the circumferential direction and the length direction of the light emitting portion 13, and the near-infrared light can be uniformly irradiated to the entire cholangiocarcinoma (photosensitive substance attached thereto, etc.) around the light emitting portion 13.

[0157] Note that, the wiring substrate 30 can be embedded inside the light emitting portion 13 by filling a transparent resin material (for example, the same resin as that constituting the light emitting portion) in each of the peripheral cavities 132 to 135 in which the wiring substrate 30 is arranged.

[0158] Thus, it is possible to prevent the positional deviation of the wiring substrate 30, the scattering of light, and the like.

[0159] As shown in Figs. 1 to 3, the anode terminal 36 and the cathode terminal 37 of the wiring substrate 30 are connected to the top end of the anode-side lead 51 and the top end of the cathode-side lead 52, respectively. Figure 3 Figure 4A Figure 5 As shown in Figs. 1 to 3, the anode terminal 36 and the cathode terminal 37 of the wiring substrate 30 are connected to the top end of the anode-side lead 51 and the top end of the cathode-side lead 52, respectively. Figure 5 Note that, in Figs. 1 to 3, only two of the four wiring substrates 30 are illustrated.

[0160] ​​​The four anode-side lead wires 51 constituting the light irradiation device 100 pass through the inside of the cavity switching section 12 from each of the peripheral cavities 132 to 135 of the light emitting section 13 provided with the wiring substrate 30 having the anode terminals 36 connected to the tip end portions of the respective anode-side lead wires 51, are inserted into the second cavity 112 of the tube main body 11, extend along the second cavity 112, are gathered into one at the middle of the second cavity 112 to become the aggregated lead wire 51G, and the aggregated lead wire 51G is drawn out to the outside of the tube 10 from the opening 114.

[0161] The four cathode-side lead wires 52 constituting the light irradiation device 100 pass through the inside of the cavity switching section 12 from each of the peripheral cavities 132 to 135 of the light emitting section 13 provided with the wiring substrate 30 having the cathode terminals 37 connected to the tip end portions of the respective cathode-side lead wires 52, are inserted into the second cavity 112 of the tube main body 11, extend along the second cavity 112, are gathered into one at the middle of the second cavity 112 to become the aggregated lead wire 52G, and the aggregated lead wire 52G is drawn out to the outside of the tube 10 from the opening 114.

[0162] As described above, the four anode-side lead wires 51 are aggregated into one aggregated lead wire 51G, the four cathode-side lead wires 52 are aggregated into one aggregated lead wire 52G, and the aggregated lead wire 51G and the aggregated lead wire 52G are drawn out to the outside of the tube 10, and according to this constitution, it is only necessary to perform the connection operation to the power supply once on the anode side and the cathode side, respectively, and it is possible to seek to simplify the connection operation to the power supply.

[0163] As shown in Figs. 1 to 3, the light irradiation device 100 is constituted by the tube 10, the power supply 91, and the device-side connector 55. Figure 3 Figure 4A Figure 4B Figure 5 As shown in Figs. 1 to 3, the light irradiation device 100 is constituted by the tube 10, the power supply 91, and the device-side connector 55.

[0164] According to this constitution, when the base end portions of the aggregated lead wire 51G or the aggregated lead wire 52G are connected to the power supply, it is possible to reliably prevent the lead wires from being pulled in the base end direction so that the tip end portions of the anode-side lead wires 51 or the cathode-side lead wires 52 are detached from the anode terminals 36 or the cathode terminals 37 of the wiring substrate 30 or prevent the plurality of lead wires (the anode-side lead wires 51 and / or the cathode-side lead wires 52) from being entangled in the cavity switching section.

[0165] As shown in Figs. 1 to 3, the light irradiation device 100 is constituted by the tube 10, the power supply 91, and the device-side connector 55. Figure 5 By connecting the device-side connector 55 to the power supply-side connector 95 of the power supply device 90 shown in Fig. 4, the base end portions of the aggregated lead wire 51G and the aggregated lead wire 52G are connected to the power supply 91 (anode and cathode) of the power supply device 90, respectively.

[0166] Figure 6 By connecting the device-side connector 55 to the power supply-side connector 95 of the power supply device 90 shown in Fig. 4, the base end portions of the aggregated lead wire 51G and the aggregated lead wire 52G are connected to the power supply 91 (anode and cathode) of the power supply device 90, respectively.​​​​

[0167] Thus, the anode terminal 36 of each wiring substrate 30 is electrically connected to the power source 91 (anode) of the power source device 90 via the anode-side lead wire 51 (aggregated lead wire 51G), and the cathode terminal 37 of each wiring substrate 30 is electrically connected to the power source 91 (cathode) of the power source device 90 via the anode-side lead wire 52 (aggregated lead wire 52G).

[0168] The power source 91 constituting the power source device 90 is not particularly limited, and is constituted by, for example, a button-type battery.

[0169] The power source device 90 is provided with an ON-OFF switch 93 of the power source 91 and a variable resistor 97 that changes the current from the power source 91 to adjust the amount of light emission from the light-emitting element 35.

[0170] As shown in Figs. 1 and 2, the light-emitting element 35 is mounted on the wiring substrate 30. Figure 1 , Figure 2E , Figure 2F and Figure 5 As shown in Figs. 1 and 2, the light-emitting element 35 is mounted on the wiring substrate 30.

[0171] The lead wire protection sleeve 70 constituting the light irradiation device 100 is attached so as to completely enclose the aggregated lead wire 51G and the aggregated lead wire 52G that protrude from the opening 114 at the base end face of the tube 10.

[0172] The lead wire protection sleeve 70 is constituted by a peel away sheath having a slit 75 formed at the base end portion thereof, and by tearing the lead wire protection sleeve 70 using the slit 75, the lead wire protection sleeve 70 can be easily removed from the tube 10.

[0173] The length of the lead wire protection sleeve 70 is generally set to 10 mm to 3000 mm, and if one preferred example is shown, it is 1100 mm.

[0174] In the present embodiment, the lead wire protection sleeve 70 is attached to the base end side of the tube 10 by overlapping and temporarily bonding the tip end portion 71 of the lead wire protection sleeve 70 with the base end portion of the tube 10 (for example, a portion from the base end to 60 mm to 100 mm, and as one preferred example, a portion from the base end to 80 mm).

[0175] The light irradiation device 100 of the present embodiment can be used to perform photodynamic therapy for bile duct cancer as described in (1) to (8) below.

[0176] (1) A combination of an antibody and a photosensitizing substance (for example, IR700) is administered into the body by intravenous injection or the like, and the combination is attached to the cancer tissue of the bile duct cancer.

[0177] (2) The tube 10 of the light irradiation device 100 is inserted into the working chamber of an endoscope (side-viewing endoscope). (3) The light irradiation device 100 is inserted into the working channel of the endoscope. (4) The light irradiation device 100 is inserted into the working channel of the endoscope, and the tube 10 is inserted into the working chamber of the endoscope. (5) The light irradiation device 100 is inserted into the working channel of the endoscope, and the tube 10 is inserted into the working chamber of the endoscope. (6) The light irradiation device 100 is inserted into the working channel of the endoscope, and the tube 10 is inserted into the working chamber of the endoscope. (7) The light irradiation device 100 is inserted into the working channel of the endoscope, and the tube 10 is inserted into the working chamber of the endoscope. (8) The light irradiation device 100 is inserted into the working channel of the endoscope, and the tube 10 is inserted into the working chamber of the endoscope.

[0178] (3) Insert the endoscope from the patient's mouth so that the tip portion of the endoscope reaches the duodenal papilla portion.

[0179] (4) Insert the guide wire, which is inserted through the inside (the first lumen 111, the communication path 121, the central lumen 131, the diameter-expanded communication path 141, and the lumen 151) of the tube 10, into the bile duct.

[0180] (5) Insert the tube 10 along the guide wire into the bile duct, and arrange the light-emitting portion 30 so as to be in contact with the bile duct cancer (i.e., block the stenosis site caused by the bile duct cancer by the light-emitting portion 30).

[0181] (6) Pull out the guide wire and the endoscope, and leave only the tube 10 in the body.

[0182] (7) Cause the base end portion of the tube 10, which protrudes from the mouth, to protrude from the nostril via the nasal cavity.

[0183] (8) Turn on the switch 93 of the power supply device 90 to supply power from the power supply 91 to the light-emitting element 35 of the wiring substrate 30, and cause the light-emitting element 35 to emit light, and irradiate the bile duct cancer located around the light-emitting portion 13. Thus, it is possible to perform photoimmunotherapy by causing the photosensitive substance attached to the cancer tissue to react.

[0184] According to the light irradiation device 100 of this embodiment, the wiring substrate 30 is arranged in each of the four peripheral lumens 132 to 135 arranged around the central lumen 131 of the light-emitting portion 13 at intervals of 90°, with the seven light-emitting elements 35 arranged at equal intervals in the length direction of the light-emitting portion 13. Thus, it is possible to emit near-infrared light in a radial pattern without deviation in the circumferential direction and the length direction of the light-emitting portion 13, and to uniformly irradiate the bile duct cancer around the light-emitting portion 13 as a whole.

[0185] Further, even if the light-emitting portion 13 is arranged so as to block the stenosis site of the bile duct, it is possible to cause the bile to flow into the lumen 151, which is the tip end portion 15 of the drainage tube, and to flow through the diameter-expanded communication path 141 of the lumen diameter-expanding portion 14, the central lumen 131 of the light-emitting portion 13, the communication path 121 of the lumen switching portion 12, and the first lumen 111 of the tube main body 11, and to discharge the bile from the opening of the side hole 113 formed in the peripheral wall of the tube main body 11 to the outside of the body.

[0186] Further, the near-infrared light emitted from the light-emitting element 35 of the wiring substrate 30 arranged in each of the peripheral lumens 132 to 135 is not blocked by the bile flowing through the central lumen 131.

[0187] Further, in the tube main body 11, the anode-side lead wire 51 (aggregated lead wire 51G) and the cathode-side lead wire 52 (aggregated lead wire 52G) are extended along the second cavity 112, and the patient's bile is circulated in the first cavity 111, so that the patient's bile does not come into contact with these lead wires, and short-circuiting between the anode-side lead wire 51 and the cathode-side lead wire 52, contamination of the lead wires, and the like due to contact with the bile can be avoided.

[0188] Further, the aggregated lead wire 51G and the aggregated lead wire 52G are caused to protrude from the opening 114 of the second cavity 112 at the base end face of the tube 10, and the bile circulated in the first cavity 111 is discharged to the outside of the body from the side hole 113 formed in the peripheral wall of the tube main body 11, so that the aggregated lead wire 51G and the aggregated lead wire 52G protruding from the opening 114 can be prevented from coming into contact with the bile.

[0189] Further, in the inside of the cavity switching portion 12, the anode-side lead wire 51 and the cathode-side lead wire 52 are sealed (bonded) by the resin material constituting the cavity switching portion 12, so that when the base end portions of the aggregated lead wire 51G or the aggregated lead wire 52G are connected to the power supply, the lead wires can be reliably prevented from being pulled in the base end direction so that the tip end portions of the anode-side lead wire 51 or the cathode-side lead wire 52 are detached from the anode terminal 36 or the cathode terminal 37 of the wiring substrate 30 or the plurality of lead wires (the anode-side lead wire 51 and / or the cathode-side lead wire 52) are prevented from being entangled in the cavity switching portion.

[0190] Further, in the second cavity 112 of the tube main body 11, the four anode-side lead wires 51 are aggregated to become one aggregated lead wire 51G, and the four cathode-side lead wires 52 are aggregated to become one aggregated lead wire 52G, and the aggregated lead wire 51G and the aggregated lead wire 52G are caused to protrude to the outside of the tube 10, so that only one connection operation to the power supply is required on the anode side and the cathode side, respectively, and the connection operation to the power supply can be simplified.

[0191] Further, the lead wire protection cover 70 constituted by a peelable sheath is attached to the base end side of the tube main body 11 in a manner of enclosing the aggregated lead wire 51G and the aggregated lead wire 52G protruding from the opening 114 of the second cavity 112, so that when the base end portion of the tube 10 is caused to protrude from the nostril via the nasal cavity of the patient, the aggregated lead wire 51G and the aggregated lead wire 52G can be prevented from being wetted with nasal mucus or the like, and after the base end portion of the tube 10 is caused to protrude from the nostril of the patient, the aggregated lead wire 51G and the aggregated lead wire 52G in a state not wetted can be connected to the power supply by peeling off the lead wire protection cover 70.

[0192] The above describes one embodiment of the present application, but the present application is not limited to this, and appropriate modifications can be made.

[0193] For example, in the light emitting portion, the number of the peripheral cavities in which the wiring substrate is disposed is not limited to 4, and can be 3 to 6.

[0194] However, in the case where the number of wiring substrates is less than 4 (the arrangement angle interval exceeds 90°), there are cases where a region where sufficient light emission amount cannot be obtained is generated in the circumferential direction of the light emission portion, and from this viewpoint, the number of wiring substrates is preferably 4 to 6, and most preferably 4.

[0195] The cancer that becomes the subject of the photodynamic therapy performed by the light irradiation device of the present application is not limited to cholangiocarcinoma, and can be applied to pancreatic cancer, lung cancer, esophageal cancer, large intestine cancer, stomach cancer, bladder cancer, prostate cancer, and the like.

[0196] Explanation of Reference Numerals

[0197] 100: light irradiation device;

[0198] 10: tube;

[0199] 11: tube main body;

[0200] 111: first cavity;

[0201] 112: second cavity;

[0202] 113: side hole;

[0203] 114: opening (base end of tube);

[0204] 12: cavity switching portion;

[0205] 121: communication path;

[0206] 13: light emission portion;

[0207] 131: central cavity;

[0208] 132 to 135: peripheral cavity;

[0209] 14: cavity diameter expansion portion;

[0210] 141: diameter expansion communication path;

[0211] 15: topmost end portion;

[0212] 151: cavity of topmost end portion;

[0213] 152: opening (top end of tube);

[0214] 153: side hole;

[0215] 30: wiring substrate;

[0216] 35: light emission element;

[0217] 36: anode terminal;

[0218] 37: cathode terminal;

[0219] 51: anode-side lead wire;

[0220] 51G: aggregated lead wire;

[0221] 52: cathode-side lead wire;

[0222] 52G: aggregated lead wire;

[0223] 55: device-side connector;

[0224] 70: lead wire protection cover;

[0225] 71: top end portion of lead wire protection cover;

[0226] 75: cut slit;

[0227] 90: power supply device;

[0228] 91: power supply;

[0229] 93: ON-OFF switch;

[0230] 95: power supply-side connector;

[0231] 97: variable resistor.

Claims

1. A light irradiation device for irradiating a affected area with light of a specific wavelength required in photoimmunotherapy, characterized in that, The light irradiation device includes: a tube having a light-emitting portion and being inserted into a body; a plurality of wiring boards disposed inside the light-emitting portion of the tube and mounting light-emitting elements that emit light of the specific wavelength; a central cavity extending along a central axis of the tube and having an opening on a tip end side of the tube, and a plurality of peripheral cavities arranged at equal angular intervals around the central cavity and having openings on the tip end side of the tube, the wiring boards being disposed in each of the peripheral cavities in a state in which the light-emitting elements are disposed outward in a radial direction of the light-emitting portion.

2. The light irradiation device according to claim 1, wherein the plurality of peripheral cavities are arranged in a circumferential direction of the central cavity when viewed in a cross section perpendicular to the central axis.

3. The light irradiation device according to claim 2, wherein the light-emitting portion has four peripheral cavities, the four peripheral cavities are arranged at equal intervals around the central cavity when viewed in a cross section perpendicular to the central axis.

4. The light irradiation device according to any one of claims 1 to 3, wherein the peripheral cavities extend along the central axis, the light-emitting portion has a plurality of light-emitting elements, the plurality of light-emitting elements are arranged along the central axis.

5. The light irradiation device according to any one of claims 1 to 3, wherein the wiring boards have an anode terminal and a cathode terminal, the light irradiation device has an anode-side lead wire connected to the anode terminal and a cathode-side lead wire connected to the cathode terminal.

6. The light irradiation device according to claim 5, wherein the tube has a tube main body at a position closer to a base end side of the tube than the light-emitting portion, a first cavity and a second cavity are formed in the tube main body of the tube, the first cavity communicates with the central cavity of the light-emitting portion, the first cavity is displaced from the central axis of the tube in a radial direction of the tube and extends parallel to the central axis, the second cavity extends parallel to the first cavity and has an opening on a base end surface of the tube, the anode-side lead wire and the cathode-side lead wire are inserted from each of the peripheral cavities into the second cavity, extend along the second cavity, and protrude from the opening of the base end surface.

7. The light irradiation device according to claim 6, wherein the tube has a cavity switching portion between the light-emitting portion and the tube main body, the cavity switching portion seals the anode-side lead wire and the cathode-side lead wire and has a communication path that communicates the central cavity and the first cavity.

8. The light irradiation device according to claim 6, wherein the plurality of peripheral cavities respectively accommodate the wiring boards, the plurality of anode-side lead wires and the plurality of cathode-side lead wires that are inserted from each of the peripheral cavities into the second cavity are respectively gathered into one and protrude from the opening of the base end surface of the tube.

9. The light irradiation device according to claim 6, wherein the first cavity is closed at a base end surface of the tube main body, The tube body has a side hole extending from the outer peripheral surface to the first cavity.

10. The light irradiation device according to claim 9, characterized in that, The tube body has markings on its outer circumferential surface indicating the location of the side holes.

11. The light irradiation device according to claim 6, characterized in that, A lead wire protective sleeve is installed on the base end side of the tube. The lead wire protective sleeve internally wraps the anode-side lead and the cathode-side lead that extend from the opening on the base end face of the tube, and can be easily detached from the tube.

12. The light irradiation device according to any one of claims 1 to 3, characterized in that, The tube has a single-cavity structure at its very top on the top side of the light-emitting part. The topmost part has a cavity that communicates with the central cavity.

13. The light irradiation device according to claim 12, characterized in that, The topmost portion has at least one side hole extending from the outer peripheral surface of the topmost portion to the cavity.

14. The light irradiation apparatus according to claim 12, wherein The diameter of the cavity is larger than the diameter of the central cavity. The tube has a cavity expansion section between the light-emitting part and the topmost part, and the cavity expansion section has an expansion communication path that connects the central cavity and the cavity.

15. The light irradiation device according to any one of claims 1 to 3, wherein, The light irradiation device is used for photoimmunotherapy of at least one of cholangiocarcinoma and pancreatic cancer.

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