Centrifugal piston and centrifugal separation device including the same

Abstract

The centrifugal piston may include a piston body and a counterweight. In a centrifugal environment, the first outer counterweight surface of the counterweight may contact the first inner body surface of the piston body, and a gap may be formed between the first inner body surface and the recess of the counterweight.

Description

Technical Field

[0001] This invention relates to a centrifugal piston and a centrifugal separation apparatus including the same. Background Technology

[0002] Adipose tissue obtained from a living organism through absorption and cutting contains a mixture of impurities (e.g., oil). Therefore, techniques for removing impurities from adipose tissue obtained from a living organism have been developed to obtain pure fat masses. For example, a piston for centrifugation is disclosed in Patent Publication No. 10-2446918. The above background technology was acquired or obtained during the derivation of this invention and is not prior art disclosed before this application. Summary of the Invention

[0003] Technical issues

[0004] One embodiment of the present invention provides a centrifugal piston and a centrifugal separation device including the same, wherein, under the condition of applying centrifugal force, the flow path is not closed, but a target substance (e.g., oil) of a specified size is allowed to pass through the flow path.

[0005] Technical solution

[0006] According to one embodiment, a centrifugal piston may include a piston body and a counterweight. The piston body includes: a first outer body surface; a second outer body surface opposite to the first outer body surface; a lateral outer body surface formed between the first outer body surface and the second outer body surface; a first inner body surface opposite to the first outer body surface; a lateral inner body surface connected to the first inner body surface and opposite to the lateral outer body surface; a first inlet disposed on the first outer body surface; an outlet disposed on the second outer body surface; a hollow portion formed by the first inner body surface and the lateral inner body surface; and a first inflow passage connecting the... The first inlet and the hollow portion, wherein the counterweight is disposed in the hollow portion, includes: a first external counterweight surface facing the first internal main body surface; a second external counterweight surface opposite to the first external counterweight surface; a lateral external counterweight surface formed between the first external counterweight surface and the second external counterweight surface; and a recess disposed on the first external counterweight surface. In a centrifugal environment, when the first external counterweight surface contacts the first internal main body surface, the counterweight forms a gap between the first internal main body surface and the recess, and at least one substance separated from the biological tissue by centrifugation is discharged through the first inlet, the first inflow passage, the gap, and the outlet.

[0007] In one embodiment, the gap can be measured as the distance between the first inner body surface and the recess, and its size is between about 50 μm and about 200 μm.

[0008] In one embodiment, the gap may have a substantially constant size between the first external counterweight surface and the side external counterweight surface.

[0009] In one embodiment, the hollow portion may include a discharge passage that connects the first inflow passage and the outlet and includes the gap.

[0010] In one embodiment, the recess may include: a recess wall surface that intersects with the first external counterweight surface; and a recess bottom surface formed between the recess wall surface and the side external counterweight surface.

[0011] In one embodiment, the wall surface of the recess may not overlap with the first inflow passage.

[0012] In one embodiment, the bottom surface of the recess may overlap with both the first inflow passage and the first internal body surface.

[0013] In one embodiment, the bottom surface of the recess can be directly connected to the external counterweight surface on the side.

[0014] In one embodiment, the recess may be formed along the circumferential direction of the counterweight.

[0015] In one embodiment, the piston body may further include: a second inlet disposed on the first outer body surface; and a second inflow passage connecting the second inlet and the hollow portion.

[0016] In one embodiment, the centrifugal piston may further include a seal disposed on the inner side body surface for sealing the space between the plunger and the outlet.

[0017] In one embodiment, the centrifugal piston may further include a stop portion disposed on the inner side surface of the main body and between the counterweight and the seal, for limiting the movement of the seal.

[0018] In one embodiment, the centrifugal piston may further include a fastening portion disposed between the counterweight and the outlet.

[0019] In one embodiment, the centrifugal piston may further include a seal disposed on the external counterweight surface on the side.

[0020] According to one embodiment, a centrifugal separation device may include: a rotating shaft; a syringe, which rotates relative to the rotating shaft for retaining biological tissue; and a centrifugal piston disposed inside the syringe, the centrifugal piston including a piston body and a counterweight, the piston body including: a first outer body surface; a second outer body surface opposite to the first outer body surface; a lateral outer body surface formed between the first outer body surface and the second outer body surface; a first inner body surface opposite to the first outer body surface; a lateral inner body surface connected to the first inner body surface and opposite to the lateral outer body surface; a first inlet disposed on the first outer body surface; an outlet disposed on the second outer body surface; and a hollow portion formed by the first inner body surface and the lateral outer body surface. An internal main body surface is formed; and a first inflow passage connects the inlet and the hollow portion, wherein the counterweight is disposed in the hollow portion, comprising: a first external counterweight surface facing the first internal main body surface; a second external counterweight surface opposite to the first external counterweight surface; a lateral external counterweight surface formed between the first external counterweight surface and the second external counterweight surface; and a recess disposed on the first external counterweight surface. In a centrifugal environment in which the syringe rotates relative to the rotation axis, when the first external counterweight surface contacts the first internal main body surface, the counterweight forms a gap between the first internal main body surface and the recess, and at least one substance centrifuged from the biological tissue is discharged through the first inlet, the first inflow passage, the gap, and the outlet.

[0021] A method of using a centrifugal separation device according to an embodiment may include: providing biological tissue and a centrifugal piston into the interior of the syringe; and rotating the syringe relative to the rotation axis to centrifuge the biological tissue, wherein centrifuging the biological tissue includes: when the first external counterweight surface contacts the first internal main body surface, at least one substance centrifuged from the biological tissue is discharged through the inlet, the first inflow passage, the slit, and the outlet.

[0022] The effects of the invention

[0023] According to one embodiment, under centrifugal force, the flow path is not closed, but rather the target material of a specified size is allowed to pass through the flow path. The effects of the centrifugal piston and centrifugal separation device of one embodiment are not limited to those mentioned above; other effects not mentioned can be clearly understood by those skilled in the art from the following description. Attached Figure Description

[0024] Referring to the accompanying drawings, the above description and other embodiments, features and advantages of the present invention will be clearly understood from the following detailed description of specific embodiments.

[0025] Figure 1 This is a perspective view of a centrifugal separation device according to an embodiment.

[0026] Figure 2 This is a cross-sectional view of a centrifugal separation device according to an embodiment.

[0027] Figure 3 This is a perspective view of a centrifugal piston according to one embodiment.

[0028] Figure 4 An exploded side view of a centrifugal piston according to one embodiment.

[0029] Figure 5 This is an exploded side sectional view of a centrifugal piston according to one embodiment.

[0030] Figure 6 This is a side sectional view of the piston body according to one embodiment.

[0031] Figure 7 This is a side sectional view of the counterweight in one embodiment.

[0032] Figure 8 This is a cross-sectional view of the stop portion according to one embodiment.

[0033] Figure 9 This is a top view of a stop portion according to one embodiment.

[0034] Figure 10 This is a cross-sectional view of a centrifugal piston according to a first embodiment of an example.

[0035] Figure 11 As an example Figure 10 Enlarged view of the centrifugal piston.

[0036] Figure 12 This is a cross-sectional view of a centrifugal piston according to a second embodiment of an example.

[0037] Figure 13 This is a cross-sectional view of a centrifugal separation device including a plunger and a centrifugal piston, according to one embodiment. Detailed Implementation

[0038] Hereinafter, embodiments will be described in detail with reference to the accompanying drawings. However, the embodiments may have various modifications, and the scope of protection of the invention is not limited to or restricted to these embodiments. All modifications, equivalent technical solutions, or alternative technical solutions to the embodiments should be included within the scope of protection of the invention.

[0039] The terminology used in the embodiments is for illustrative purposes only and is not intended to limit the invention. Unless the context clearly indicates otherwise, the singular includes the plural. In this specification, terms such as "comprising" or "having" are used to specify the presence of features, numbers, steps, actions, structural elements, components, or combinations thereof recorded in the specification, and do not presuppose the presence or additional possibilities of one or more other features, numbers, steps, actions, structural elements, components, or combinations thereof.

[0040] Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Terms as defined in commonly used dictionaries have the same meaning in the context of the relevant English art and should not be construed as having an ideal or excessive meaning unless expressly defined herein.

[0041] Furthermore, in the description with reference to the accompanying drawings, the same structural elements are assigned the same reference numerals regardless of the reference numerals, and repeated descriptions thereof are omitted. In the description of embodiments, detailed descriptions of related well-known technologies will be omitted if it is determined that a detailed explanation of those technologies would obscure the main idea of ​​the embodiment.

[0042] Furthermore, in describing the structural elements of the embodiments, terms such as first, second, A, B, (a), and (b) may be used. These terms are used to distinguish between two structural elements, and the nature, number, or order of the corresponding structural elements are not limited to the aforementioned terms. When a structural element is described as being "connected," "combined," or "linked" with other structural elements, it should be understood that a structural element can be directly connected or linked with other structural elements, and that other structural elements can also be "connected," "combined," or "linked" between various structural elements.

[0043] Structural elements that perform the same function as those included in one embodiment may be described using the same names in other embodiments. Unless otherwise stated, the description described in one embodiment is also applicable to other embodiments, with specific details omitted to the extent necessary for repetition.

[0044] Figure 1 This is a perspective view of a centrifugal separation device according to an embodiment.

[0045] Reference Figure 1 The centrifugal separation device 100 can remove impurities (e.g., oil, blood, pharmaceutical solutions and / or other impurities) from biological tissue (e.g., adipose tissue) and obtain pure biological tissue obtained from an organism (e.g., a human) under centrifugal separation conditions.

[0046] The centrifugal separator 100 may include a base 101. The base 101 may be substantially flat. The base 101 may include a rotating shaft X. The rotating shaft X may be located at the center of the base 101.

[0047] The centrifugal separation device 100 may include a plurality of cavities 102. The plurality of cavities 102 are arranged around the base 101 in a circumferential direction.

[0048] The centrifugal separator 100 may include a plurality of hinges 103. The plurality of hinges 103 are rotatably connected to the base 101.

[0049] The centrifugal separator 100 may include a plurality of supports 104. The plurality of supports 104 may be connected to a corresponding hinge 103. The plurality of supports 104 may be arranged around the rotation axis X in a circumferential direction. The plurality of supports 104 may swing in and out of a corresponding cavity 102 via a corresponding hinge 103. The plurality of supports 104 may rotate together with the base 101 relative to the rotation axis X.

[0050] The centrifugal separation device 100 may include at least one syringe 105. The syringe 105 may be configured in a corresponding one of a plurality of supports 104.

[0051] Figure 2 This is a cross-sectional view of a centrifugal separation device according to an embodiment.

[0052] Reference Figure 2 The centrifugal separation device 100 may include a syringe 105. The syringe 105 can rotate relative to the rotation axis X in a centrifugal separation environment.

[0053] The syringe 105 may include a container 1051. The container 1051 may hold biological tissue BM. The container 1051 may be substantially cylindrical in shape.

[0054] The syringe 105 may include a connector 1052. The connector 1052 allows passage of at least one first substance (e.g., a substance with a relatively greater specific gravity than blood, medication, water, and / or other pure fat). At least one first substance can be removed from the container 1051 via the connector 1052. The connector 1052 may be configured at a first end of the container 1051 located at a first distance (e.g., a relatively large distance) from the axis of rotation X. Figure 2 (the front end).

[0055] Connector 1052 may include a fastening portion 1052A. The fastening portion 1052A may be coupled to an external removal device (not shown). For example, the fastening portion 1052A may include threads.

[0056] Connector 1052 may include a discharge and injection passage 1052B. Discharge and injection passage 1052B may allow at least one first substance to pass through.

[0057] The syringe 105 may include a flange 1053. The flange 1053 may be configured at a second end of the container 1051 at a second distance (e.g., a relatively close distance) from the rotation axis X, which is smaller than a first distance. Figure 2 (The rear end). The second end of container 1051 may be arranged opposite to the first end.

[0058] The second end of container 1051 may be formed open on the outside of syringe 105. Biological tissue BM obtained from a living organism may be disposed inside container 1051 via discharge and injection passage 1052B. Piston 106 may be disposed on or above the aforementioned biological tissue BM (e.g., Figure 2 (Right side). During use of the centrifugal separation device 100, the piston 106, subjected to a centrifugal force in a direction away from the rotation axis X, can pressurize the biological tissue BM. Within the centrifugal separation environment, at least one second substance (e.g., a substance with a relatively lower specific gravity than oil and / or other purely adipose tissue) can be separated from the biological tissue BM. During the rotation of the piston 106 relative to the rotation axis X and the pressurization of the biological tissue BM, at least one second substance moves from the interior of the piston 106 to the exterior of the piston 106 and toward the second end of the container 1051.

[0059] Figure 3 This is a perspective view of a centrifugal piston according to one embodiment. Figure 4 An exploded side view of a centrifugal piston according to one embodiment. Figure 5 This is an exploded side sectional view of a centrifugal piston according to one embodiment. Figure 6 This is a side sectional view of the piston body according to one embodiment.

[0060] Reference Figures 3 to 6 The centrifugal piston 106 may include a piston body 110. The piston body 110 may be located in... Figure 2 The piston body 110 can move within the container 1051. For example, the piston body 110 can move away from the rotation axis X within the centrifugation environment. The piston body 110 can apply pressure to the biological tissue BM.

[0061] The piston body 110 may include: a first outer body surface 111 (e.g., a front outer body surface); a second outer body surface 112 (e.g., a rear outer body surface), opposite to the first outer body surface 111; and a side outer body surface 113, formed between the first outer body surface 111 and the second outer body surface 112.

[0062] The first outer body surface 111 may include a first outer region 111A. For example, when Figure 2 When the piston 106 is positioned in the portion of the container 1051 adjacent to the connector 1052 (e.g., the front portion), the first outer region 111A can pressurize the space between the connector 1052 and the piston 106. During the pressurization of the space by the first outer region 111A, substances present in the space (e.g., air, blood, medication, and / or water) can be facilitated to be discharged through the discharge and injection passage 1052B.

[0063] The first outer body surface 111 may include a second outer region 111B. The second outer region 111B may include surfaces that are inclined relative to the first outer region 111A and the side outer body surface 113, respectively. For example, when the piston 106 is in a centrifugal separation environment, the second outer region 111B may guide substances present in the space pressurized by the first outer region 111A. The second outer region 111B may be connected to the first outer region 111A and the side outer body surface 113.

[0064] The piston body 110 may include a first inner body surface 114 opposite to the first outer body surface 111 and a side inner body surface 116 connected to the first inner body surface 114. The first inner body surface 114 and the side inner body surface 116 may form a hollow portion 117.

[0065] The first inner main surface 114 may include a first inner region 114A. The first inner region 114A may be configured opposite to the first outer region 111A.

[0066] The first inner main surface 114 may include a second inner region 114B. The second inner region 114B may be disposed opposite to the second outer region 111B. The second inner region 114B may include a surface inclined relative to the first inner region 114A. The second inner region 114B may be connected to the first inner region 114A.

[0067] The side interior surface 116 may include a first side interior region 116A. The first side interior region 116A may define a first interior diameter of the hollow portion 117. The first side interior region 116A may be connected to a second interior region 114B.

[0068] The side interior surface 116 may include a second side interior region 116B. The second side interior region 116B may define a second interior diameter of the hollow portion 117. The second interior diameter may be larger than the first interior diameter. The second side interior region 116B may be connected to the first side interior region 116A.

[0069] The side interior surface 116 may include a third side interior region 116C. The third side interior region 116C may define a third interior diameter of the hollow portion 117. The third interior diameter may be larger than the second interior diameter. The third side interior region 116C may be connected to the second side interior region 116B and the second outer exterior surface 112.

[0070] The side interior main body surface 116 may have a first height difference between the first side interior region 116A and the second side interior region 116B. The side interior main body surface 116 may have a second height difference between the second side interior region 116B and the third side interior region 116C.

[0071] The piston body 110 may include a plurality of grooves G. The plurality of grooves G may be configured on the side outer body surface 113. The plurality of grooves G may be arranged along the side outer surface 113 between the first outer body surface 111 and the second outer body surface 112.

[0072] The piston body 110 may include a first inlet F1. The first inlet F1 allows material on a first outer body surface 111 to flow into the piston body 110. The first inlet F1 may be configured in a second outer region 111B.

[0073] The piston body 110 may include a second inlet F2. The second inlet F2 allows material on the first outer body surface 111 to flow into the piston body 110. The second inlet F2 may be configured in a portion of the second outer region 111B that is different from the portion of the region where the first inlet F1 is configured. The position of the second inlet F2 may be opposite to the position of the first inlet F1.

[0074] The piston body 110 may include a first inflow passage P1. The first inflow passage P1 may fluidly connect a first inflow inlet F1 and a hollow portion 117. The first inflow passage P1 may be disposed between a first outer body surface 111 and a first inner body surface 114.

[0075] The piston body 110 may include a second inflow passage P2. The second inflow passage P2 may fluidly connect the second inlet F2 and the hollow portion 117. The second inflow passage P2 may be disposed between the first outer body surface 111 and the first inner body surface 114. The second inflow passage P2 and the first inflow passage P may be substantially on the same line.

[0076] The piston body 110 may include an outlet F3. The outlet F3 allows material in the hollow portion 117 to flow out to the outside of the piston body 110. The outlet F3 may be formed on the second outer body surface 112.

[0077] The piston body 110 may include a slit SL. The slit SL may be configured between the outer side body surface 113 and the inner side body surface 116. The slit SL may also be configured in a third inner side region 116C.

[0078] Figure 7 This is a side sectional view of the counterweight in one embodiment.

[0079] Reference Figures 3 to 5 and Figure 7 The piston 106 may include a counterweight 120. The counterweight 120 may allow the movement of at least one substance (e.g., oil) between the front space of the piston body 110 and the rear space of the piston body 110, and may prevent the movement of other substances (e.g., pure adipose tissue from which oil has been removed).

[0080] The counterweight 120 may include: a first external counterweight surface 121 (e.g., a front external counterweight surface); a second external counterweight surface 122 (e.g., a rear external counterweight surface), opposite to the first external counterweight surface 121; and a side external counterweight surface 123, formed between the first external counterweight surface 121 and the second external counterweight surface 122.

[0081] The first external counterweight surface 121 may include a first external counterweight region 121A. The first external counterweight region 121A may face... Figure 6 The first internal region 114A. For example, when centrifugal force acts in a direction away from the rotation axis X. Figure 2 When the piston 106 is in motion, the first external counterweight region 121A may not contact the first internal region 114A and may form a space with the first internal region 114A.

[0082] The first external counterweight surface 121 may include a second external counterweight region 121B. The second external counterweight region 121B may include surfaces inclined relative to the first external counterweight region 121A and the side external counterweight surface 123, respectively. The inclination angle formed by the first external counterweight region 121A and the second external counterweight region 121B may be substantially the same as the inclination angle formed by the first internal region 114A and the second internal region 114B. The second external counterweight region 121B may be disposed between the first external counterweight region 121A and the side external counterweight surface 123. The second external counterweight region 121B may face... Figure 6 The second internal region 114B. For example, when centrifugal force acts in a direction away from the rotation axis X. Figure 2 When the piston 106 is in motion, the second external counterweight region 121B can at least partially contact the second internal region 114B.

[0083] The lateral external counterweight surface 123 may include a first lateral counterweight region 123A. The first lateral counterweight region 123A may be directly or indirectly connected to the second external counterweight region 121B. The first lateral counterweight region 123A may define a first outer diameter of the counterweight 120.

[0084] The lateral external counterweight surface 123 may include a second lateral counterweight region 123B. The second lateral counterweight region 123B may be disposed between the first lateral counterweight region 123A and the second external counterweight surface 122. The second lateral counterweight region 123B may be directly or indirectly connected to the first lateral counterweight region 123A. The second lateral counterweight region 123B may be directly connected to the second external counterweight surface 122. The second lateral counterweight region 123B may define a second outer diameter of the counterweight 120. The second outer diameter may be smaller than the first outer diameter.

[0085] The side external counterweight surface 123 may include a counterweight height difference region 123C. The counterweight height difference region 123C may be disposed between the first side counterweight region 123A and the second side counterweight region 123B.

[0086] The external lateral counterweight surface 123 can face the internal lateral main body surface 116. The external lateral counterweight surface 123 can be separated from the internal lateral main body surface 116. For example, regardless of whether centrifugal force is acting... Figure 2 The piston 106 and the external counterweight surface 123 on the side can be separated from the internal main body surface 116 on the side.

[0087] The counterweight 120 may include a first counterweight portion B1 and a second counterweight portion B2. The first counterweight portion B1 may be formed by a first external counterweight region 121A, a second external counterweight region 121B, a first lateral counterweight region 123A, and a counterweight height difference region 123C. The second counterweight portion B2 may be formed by a second lateral counterweight region 123B and a second external counterweight surface 122.

[0088] The counterweight 120 may include a recess 124. The recess 124 may be formed in a second outer counterweight region 121B. The recess 124 may be disposed between a first outer counterweight region 121A and a first lateral counterweight region 123A. The recess 124 may be detached from the first outer counterweight region 121A. The recess 124 may be directly connected to the first lateral counterweight region 123A. The recess 124 may extend along the circumferential direction of the counterweight 120.

[0089] Reference Figures 3 to 5 The plug 106 may include multiple external seals 130. The multiple external seals 130 can seal... Figure 2 The inner surface of container 1051 and Figure 6The space between the side outer body surfaces 113 of the piston body 110. For example, a plurality of external seals 130 may substantially each include an O-ring. The plurality of external seals 130 may be at least partially disposed in a plurality of grooves G.

[0090] Reference Figures 3 to 5 The piston 106 may include an internal seal 140. The internal seal 140 seals the piston body 110 from the plunger (e.g., Figure 13 The space between the plungers 107. The internal seal 140 may at least partially contact the outer surface of the plunger. The internal seal 140 may be configured in Figure 6 On the second side internal region 116B.

[0091] Figure 8 This is a cross-sectional view of the stop portion according to one embodiment. Figure 9 This is a top view of a stop portion according to one embodiment.

[0092] Reference Figure 3 and Figure 5 , Figure 8 and Figure 9 The piston 106 may include a stop portion 150. The stop portion 150 can... Figures 3 to 5 The internal seal 140 is limited to Figure 6 The second side internal region 116B. The stop portion 150 may be disposed on the second side internal region 116B. The stop portion 150 may be adjacent to the first side internal region 116A, and the internal seal 140 may be adjacent to the third side internal region 116C.

[0093] The stop portion 150 may include a first base 151. The first base 151 may be substantially circular or elliptical in ring shape. The first base 151 may contact the second side interior region 116B. The first base 151 may contact the internal seal 140.

[0094] The stop portion 150 may include a protrusion 152. The protrusion 152 may protrude radially and inwardly from the first base 151. The inner diameter of the protrusion 152 may be smaller than the inner diameter of the first base 151. The protrusion 152 may extend at least partially along the circumferential direction of the first base 151. The protrusion 152 may connect to an end face of the first base 151 (e.g., Figure 8 (The front end face of the middle).

[0095] The stop portion 150 may include a slot 153. The slot 153 may be formed on the protrusion 152 along the extending direction of the protrusion 152. For example, when the counterweight height difference region 123C contacts the protrusion 152, the slot 153 may allow material to move.

[0096] Reference Figure 4and Figure 5 The piston 106 may include a fastening portion 160. The fastening portion 160 may cooperate with the stop portion 150 and secure the internal seal 140 to the second side internal region 116B. The fastening portion 160 may be disposed on the third side internal region 116C.

[0097] The fastening part 160 may include a second base 161. The second base 161 may be substantially circular or elliptical in ring shape. The second base 161 may contact the third side internal region 116C. The second base 161 may contact the internal seal 140.

[0098] The fastener 160 may include a thread 162. The thread 162 can be used with an external fastening unit (e.g., Figure 13 The plunger 107 is fastened. Thread 162 is at least partially formed on the inner surface of the second base 161.

[0099] The fastener 160 may include a tongue 163. The tongue 163 may mate with the gap SL. The tongue 163 may be configured on the outer surface of the second base 161.

[0100] Figure 10 This is a cross-sectional view of a centrifugal piston according to a first embodiment of an example. Figure 11 As an example Figure 10 Enlarged view of the centrifugal piston.

[0101] Reference Figure 10 and Figure 11 Centrifugal force can travel along a path far from the center. Figure 2 The rotation axis X acts on piston 106. In a centrifugal environment, the centrifugal force acting on the counterweight 120 having a first weight can be greater than the centrifugal force acting on piston body 110 having a second weight smaller than the first weight. When the centrifugal force acting on counterweight 120 is greater than the sum of other forces acting on counterweight 120 (e.g., gravity, friction, and / or other forces acting on counterweight 120), counterweight 120 can move relative to piston body 110 in a direction away from outlet F3. Second outer counterweight region 121B can contact second inner region 114B. When second outer counterweight region 121B contacts second inner region 114B, recess 124 can remain separated from second inner region 114B. Thus, a gap can be formed between second inner region 114B and recess 124. The hollow portion 117 may include a discharge passage P3, which may include the gap between the second internal region 114B and the recess 124 and the gap between the side internal main body surface 116 and the side external counterweight surface 123.

[0102] Within a centrifugal environment, substances positioned in front of the piston body 110 can be separated into layers in ascending order of specific gravity, moving away from the piston body 110. The substance with the lowest specific gravity (e.g., oil) can flow into the hollow portion 117 through the first inlet F1 and the second inlet F2, along the first inlet passage P1 and the second inlet passage P2. The flowing-in substance can then flow out through the outlet F3 via the discharge passage P3 along the recess 124.

[0103] The recess 124 may include a recess bottom surface 124A. The recess bottom surface 124A may be directly connected to the external side counterweight surface 123. The recess bottom surface 124A may form a second internal region 114B and a slit. The slit may have a substantially constant size along the recess bottom surface 124A. The size of the slit may be defined as the distance between the second internal region 114B and the recess bottom surface 124A. The size of the slit may be determined to allow only the target substance (e.g., oil) to pass through while preventing the passage of other substances (e.g., adipose tissue). For example, the slit may have a size between about 50 μm and about 200 μm.

[0104] When the second external counterweight region 121B comes into contact with the second internal region 114B, the bottom surface 124A of the recess can overlap with the first inflow passage P1 and the second inflow passage P2. The bottom surface 124A of the recess can overlap with the peripheral regions of the first inflow passage P1 and the second inflow passage P2 in the second internal region 114B.

[0105] The bottom surface 124A of the recess can extend along the periphery of the counterweight 120. The bottom surface 124A of the recess can be formed around the entire periphery of the counterweight 120.

[0106] The recess 124 may include a recess wall 124B. The recess wall 124B may be disposed between the second external counterweight region 121B and the recess bottom surface 124A. The recess wall 124B may form a height difference between the second external counterweight region 121B and the recess bottom surface 124A.

[0107] When the second external counterweight region 121B comes into contact with the second internal region 114B, the recessed wall 124B will not overlap with the first inflow passage P1 and the second inflow passage P2.

[0108] Figure 12 This is a cross-sectional view of a centrifugal piston according to a second embodiment of an example.

[0109] Reference Figure 12When centrifugal force is not acting on piston 106 or the magnitude of the centrifugal force applied to counterweight 120 is less than the magnitude of other forces applied to counterweight 120, counterweight 120 may move relative to piston body 110 toward outlet F3. The first outer counterweight surface 121 may disengage from the first inner body surface 114. The stop portion 150 may restrict the movement of counterweight 120 to prevent counterweight 120 from disengaging from piston body 110. For example, the counterweight height difference region 123C may be adjacent to a portion of the stop portion 150 (e.g., Figure 8 and Figure 9 The protrusion 152) is in contact with each other.

[0110] Figure 13 This is a cross-sectional view of a centrifugal separation device including a plunger and a centrifugal piston according to one embodiment.

[0111] Reference Figure 13 The centrifugal separator 100 may include a plunger 107. The plunger 107 may be coupled to a piston 106. For example, the plunger 107 may be coupled to... Figure 5 The threaded 162 screw is used for connection.

[0112] As described above, although embodiments have been illustrated with reference to the accompanying drawings, various technical modifications and variations can be made by those skilled in the art. For example, the described techniques may be performed in a different order than the described methods, and / or the structural elements of the described systems, structures, devices, circuits, etc., may be combined or integrated in a different manner than the described methods, or suitable results may be achieved even if they are replaced or substituted by other structural elements or equivalent technical solutions.

[0113] Therefore, content equivalent to other examples, other embodiments, and the scope of the invention claims should also fall within the scope of the invention claims described below.

Claims

1. A centrifugal piston, characterized in that, Including the piston body and counterweight, The piston body mentioned above includes: First external main surface; The second external main body surface is opposite to the first external main body surface mentioned above; A side outer main body surface is formed between the aforementioned first outer main body surface and the aforementioned second outer main body surface; The first internal main body surface is opposite to the aforementioned first external main body surface; The side internal main body surface is connected to the aforementioned first internal main body surface and is opposite to the aforementioned side external main body surface; The first-level entrance is located on the aforementioned first external main body surface; The outlet is located on the aforementioned second external main body surface; The hollow portion is formed by the aforementioned first internal main body surface and the aforementioned side internal main body surface; and The first inflow path connects the aforementioned first inflow inlet and the aforementioned hollow section. The aforementioned counterweight is configured in the aforementioned hollow portion, including: The first external counterweight surface faces the aforementioned first internal main body surface; The second external counterweight surface is opposite to the first external counterweight surface described above; A lateral external counterweight surface is formed between the first external counterweight surface and the second external counterweight surface; and The recess is arranged on the above-mentioned first external weight surface, In a centrifugal environment, when the first external counterweight surface comes into contact with the first internal main body surface, the counterweight forms a gap between the first internal main body surface and the recess. At least one substance separated from biological tissue by centrifugation is discharged through the first inlet, the first inflow passage, the slit, and the outlet.

2. The centrifugal piston according to claim 1, characterized in that, The gap is measured based on the distance between the first internal main body surface and the recess, and its size is between 50 μm and 200 μm.

3. The centrifugal piston according to claim 1, characterized in that, The gap described above has a substantially constant size between the first external counterweight surface and the side external counterweight surface.

4. The centrifugal piston according to claim 1, characterized in that, The hollow portion includes a discharge passage that connects the first inflow passage and the outlet and includes the gap.

5. The centrifugal piston according to claim 1, characterized in that, The above-mentioned recesses include: The concave wall intersects with the aforementioned first external counterweight surface; and The bottom surface of the recess is formed between the wall surface of the recess and the external counterweight surface on the side.

6. The centrifugal piston according to claim 5, characterized in that, The wall surface of the aforementioned concave portion does not overlap with the aforementioned first inflow passage.

7. The centrifugal piston according to claim 5, characterized in that, The bottom surface of the aforementioned concave portion overlaps with both the aforementioned first inflow passage and the aforementioned first internal main body surface.

8. The centrifugal piston according to claim 5, characterized in that, The bottom surface of the aforementioned recess is directly connected to the aforementioned external counterweight surface on the side.

9. The centrifugal piston according to claim 1, characterized in that, The aforementioned recess is formed along the circumferential direction of the aforementioned counterweight.

10. The centrifugal piston according to claim 1, characterized in that, The piston body mentioned above also includes: The second inlet is configured on the aforementioned first external main body surface; and The second inflow passage connects the aforementioned second inlet and the aforementioned hollow section.

11. The centrifugal piston according to claim 1, characterized in that, It also includes a seal disposed on the aforementioned side inner body surface for sealing the space between the plunger and the aforementioned outlet.

12. The centrifugal piston according to claim 11, characterized in that, It also includes a stop portion disposed on the inner surface of the side body and between the counterweight and the seal, for restricting the movement of the seal.

13. The centrifugal piston according to claim 1, characterized in that, It also includes a fastening part disposed between the aforementioned counterweight and the aforementioned outlet.

14. A centrifugal separation device, characterized in that, include: Rotation axis; A syringe, rotating relative to the aforementioned axis of rotation, is used to preserve biological tissue; and The centrifugal piston is located inside the syringe described above. The aforementioned centrifugal piston includes a piston body and a counterweight. The piston body mentioned above includes: First external main surface; The second external main body surface is opposite to the first external main body surface mentioned above; A side outer main body surface is formed between the aforementioned first outer main body surface and the aforementioned second outer main body surface; The first internal main body surface is opposite to the aforementioned first external main body surface; The side internal main body surface is connected to the aforementioned first internal main body surface and is opposite to the aforementioned side external main body surface; The first-level entrance is located on the aforementioned first external main body surface; The outlet is located on the aforementioned second external main body surface; The hollow portion is formed by the aforementioned first internal main body surface and the aforementioned side internal main body surface; and The first inflow passage connects the aforementioned inlet and the aforementioned hollow portion. The aforementioned counterweight is configured in the aforementioned hollow portion, including: The first external counterweight surface faces the aforementioned first internal main body surface; The second external counterweight surface is opposite to the first external counterweight surface described above; A lateral external counterweight surface is formed between the first external counterweight surface and the second external counterweight surface; and The recess is arranged on the above-mentioned first external weight surface, In a centrifugal environment where the syringe rotates relative to the rotating axis, when the first external counterweight surface comes into contact with the first internal main body surface, the counterweight forms a gap between the first internal main body surface and the recess. At least one substance separated from the above-mentioned biological tissue by centrifugation is discharged through the above-mentioned first inlet, the above-mentioned first inflow passage, the above-mentioned gap and the above-mentioned outlet.

15. A method using the centrifugal separation apparatus according to claim 14, characterized in that, include: Providing biological tissue and a centrifuge piston into the interior of the aforementioned syringe; and The above-mentioned biological tissue is separated by centrifugation by rotating the syringe relative to the above-mentioned rotating axis. The centrifugal separation of the biological tissue includes: when the first external counterweight surface comes into contact with the first internal main body surface, at least one substance centrifugally separated from the biological tissue is discharged through the inlet, the first inflow passage, the gap and the outlet.

Images