PTP cover material and PTP packaging body

Abstract

The present invention provides a PTP cover material, characterized in that it contains a weight average molecular weight of 2.0×10 5 ~3.5×10 5 The polypropylene resin has a crystal fusion heat of 70 J / g or more as measured by a differential scanning calorimeter (DSC).

Description

Technical Field

[0001] The present invention relates to a lid material for PTP (press through pack) and a PTP packaging body. Background Art

[0002] PTP packaging, consisting of a base material and a cover material, is a well-known packaging method for pharmaceuticals, food, and the like. PTP packaging is manufactured by vacuum forming or pressure-pressing a plastic sheet made of a polyvinyl chloride resin or a polypropylene resin to form a base material with a pocket-shaped recess. After the recess is filled with the contents, the cover material is heat-sealed to the flange portion outside the recess. The contents are removed by applying force from the outside of the base material toward the cover material, thereby piercing the cover material.

[0003] Conventionally, lid materials used were aluminum foil, cellophane, and other materials that easily break when the contents are squeezed out (excellent ejection properties). However, in recent years, with the trend toward reducing disposable plastics and implementing recycling and conversion to renewable resources, recyclable and environmentally friendly PTP packaging has gained attention. These use plastic sheets for both the base and lid, eliminating the need for waste sorting when discarded.

[0004] For example, Patent Document 1 discloses a lid material having an extrusion function, which comprises a polypropylene resin film and a reinforcing resin layer laminated on the polypropylene resin film as a base material, and degrades the polypropylene resin film by irradiation with radiation.

[0005] Patent Documents 2 and 3 disclose a PTP cover material having a sheet composed of a resin composition containing a polypropylene resin and an inorganic substance (such as talc) for improving ejection properties as a base material.

[0006] Patent Document 4 discloses a cover sheet for a blister pack. In order to achieve incineration properties that allow handling under the same conditions as the base material and exhibit excellent tensile breaking load, elongation, and puncture resistance, the cover sheet contains a crystalline thermoplastic resin as an essential component and is crystallized by heat treatment.

[0007] Patent Document 5 discloses a laminated polypropylene film in which a resin having a certain range of crystalline fusion heat is laminated in the interlayer portion in order to improve interlayer adhesion in addition to hand-tearability and mechanical strength.

[0008] Patent Document 6 discloses a plastic PTP covering film and a PTP package using the covering film. In order to facilitate disposal after use and improve extrudability and print readability, a styrene-based resin and an inorganic filler are used.

[0009] Prior art literature

[0010] Patent Literature

[0011] Patent Document 1: Japanese Patent Application Laid-Open No. 7-256842

[0012] Patent Document 2: Japanese Patent Application Laid-Open No. 10-101133

[0013] Patent Document 3: Japanese Patent Application Laid-Open No. 9-11422

[0014] Patent Document 4: Japanese Patent Application Laid-Open No. 2000-7026

[0015] Patent Document 5: Japanese Patent Application Laid-Open No. 2000-25173

[0016] Patent Document 6: Japanese Patent Application Laid-Open No. 2013-234002 Summary of the Invention

[0017] Problems to be solved by the invention

[0018] However, the lid material described in Patent Document 1 has the following problems: when irradiated with radiation to degrade the polypropylene resin film, the reinforcing resin layer undergoes crosslinking, resulting in poor ejection properties; and an unpleasant odor remains due to degradation of the polypropylene resin film.

[0019] Furthermore, the lid materials described in Patent Documents 2 and 3 both have room for further improvement in terms of the opening identification performance by generating an opening sound when the lid material is pierced to take out the contents.

[0020] The lid material described in Patent Document 4 has room for improvement in terms of the above-mentioned opening identification. In addition, it is not suitable for material recycling because different resins such as polystyrene, ethylene-vinyl acetate copolymer saponification product, and nylon-6 are laminated.

[0021] The lid material described in Patent Document 5 has a problem in that ejection properties and opening identification properties are deteriorated due to the lamination of a biaxially oriented polypropylene-based resin.

[0022] The lid material described in Patent Document 6 has the following problems: since it uses a styrene-based resin, it is not suitable for recycling, and since it is coated with an emulsion-type heat sealant, it generates an unpleasant odor in a high-temperature environment.

[0023] Therefore, an object of the present invention is to provide a PTP package lid and a PTP package that are excellent in ejection properties and opening identification properties and that suppress unpleasant odors.

[0024] Means for solving problems

[0025] The present inventors have conducted intensive studies to solve the above problems and have found that a PTP lid material containing a polypropylene resin having a molecular weight within a specific range and a crystal fusion heat within a specific range can solve the above problems, thereby completing the present invention.

[0026] That is, the present invention is as follows. [1]

[0028] A PTP cover material, characterized in that it contains a weight average molecular weight of 2.0×10 5 ~3.5×10 5 The polypropylene resin has a crystal fusion heat of 70 J / g or more based on a differential scanning calorimeter (DSC). [2]

[0030] The PTP cover material according to [1], wherein the MD orientation degree is -0.035 to 0.035. [3]

[0032] The PTP cover material according to [1] or [2], wherein in a load-displacement curve during a puncture test of the PTP cover material, the maximum load per 0.1 mm displacement in the fracture region decreases to 3 to 20 N. [4]

[0034] A PTP cover material as described in any one of [1] to [3], wherein the thickness is 10 to 100 μm, the water vapor permeability is less than 10 g / m2·day, the tensile strength is 20 to 50 MPa in both MD and TD, and the tensile elongation is less than 15% in both MD and TD. [5]

[0036] The PTP covering material according to any one of [1] to [4], comprising 0.1 to 3% by mass of an inorganic substance. [6]

[0038] The PTP covering material according to any one of [1] to [5] comprises: a layer comprising the polypropylene resin; and at least one surface layer comprising a polyethylene resin, a polypropylene resin, or a polyolefin elastomer. [7]

[0040] A PTP package, characterized in that it comprises the PTP cover material according to any one of [1] to [6], and a bottom material having a recessed portion for accommodating contents.

[0041] Effects of the Invention

[0042] According to the present invention, there can be provided a lid material for a PTP package and a PTP package that are excellent in ejection property and开封识别性(It seems there is a mistake here. Maybe it should be "开封识别性" which might be something like "opening identification property"), and suppress unpleasant off-flavors. BRIEF DESCRIPTION OF THE DRAWINGS

[0043] Figure 1 It is a cross-sectional view showing an embodiment of a PTP package including the lid material for PTP of the present invention.

[0044] Figure 2 It is a graph showing an example of a load-displacement curve obtained when a puncture test is performed on the lid material for PTP of the present invention. DETAILED DESCRIPTION OF THE EMBODIMENTS

[0045] Hereinafter, the specific embodiments of the present invention (hereinafter referred to as "the present embodiments") will be described in detail. However, the present invention is not limited to the following description, and various modifications can be made within the scope of its gist.

[0046] <Lid material for PTP>

[0047] The lid material for PTP of the present embodiment (hereinafter also simply referred to as "lid material") is characterized in that it contains a polypropylene-based resin having a weight average molecular weight of 2.0×10 5 ~3.5×10 5 and the heat of fusion of crystallization based on a differential scanning calorimeter (DSC) is 70 J / g or more.

[0048] <Polypropylene-based resin>

[0049] The polypropylene-based resin contained in the lid material for PTP of the present embodiment is not particularly limited as long as the weight average molecular weight is 2.0×10 5 ~3.5×10 5 For example, propylene homopolymers, copolymers of propylene and other monomers, and modified products thereof can be cited. In addition, from the aspect of environmental protection, it can be bio-polypropylene. Among them, from the aspects of heat resistance, water vapor barrier property, and tensile elongation, propylene homopolymers are preferred.

[0050] The polypropylene-based resin can be used alone or in combination of two or more.

[0051] Examples of monomers that can be copolymerized with propylene include α-olefins such as ethylene, 1-butene, isobutene, 1-pentene, and 1-hexene. The polymerization form is not particularly limited and can be a random copolymer, a block copolymer, etc.

[0052] The method for producing the polypropylene resin is not particularly limited, and known methods such as a method of polymerizing propylene and other monomers in the presence of a catalyst can be used. Specifically, for example, a method of polymerizing propylene and other monomers in the presence of a catalyst and an alkylaluminum compound at a polymerization temperature of 0 to 100° C. and a polymerization pressure of 3 to 100 atmospheres can be used.

[0053] Examples of the catalyst include titanium trichloride catalysts and titanium halide catalysts supported on a carrier such as magnesium chloride. A chain transfer agent such as hydrogen may be added to adjust the molecular weight of the polymer.

[0054] In the production of polypropylene resins, in addition to the above-mentioned catalyst, an electron-donating compound may be used as a third component in the form of an internal or external donor component to improve the isotacticity and polymerization activity of the polypropylene. The electron-donating compound is not particularly limited, and known substances may be used. Examples thereof include ester compounds such as ε-caprolactone, methyl methacrylate, ethyl benzoate, and methyl toluate; phosphites such as triphenyl phosphite and tributyl phosphite; phosphoric acid derivatives such as hexamethylphosphoric triamide; alkoxy ester compounds; aromatic monocarboxylic acid esters; aromatic alkylalkoxysilanes; aliphatic hydrocarbon alkoxysilanes; various ether compounds; various alcohols; and various phenols.

[0055] The polymerization method in the above method can be either batch or continuous. Examples of the polymerization method include solution polymerization in a solvent such as butane, pentane, hexane, heptane, or octane; slurry polymerization; bulk polymerization in a monomer without a solvent; and gas phase polymerization in a gaseous monomer.

[0056] The polypropylene resin may also be a modified product obtained by modifying an unmodified polypropylene resin with a modifier such as an α,β-unsaturated carboxylic acid or its derivatives (including anhydrides and esters). Examples of modified polypropylene resins include those obtained by grafting or adding an α,β-unsaturated carboxylic acid or its derivatives to an unmodified polypropylene resin. Specific examples include those obtained by grafting or adding an α,β-unsaturated carboxylic acid or its derivatives to a polypropylene resin at a ratio of approximately 0.01 to 10% by mass of the total polypropylene resin.

[0057] The modified polypropylene resin can be obtained, for example, by reacting an unmodified polypropylene resin with a modifier in the presence or absence of a radical initiator in a molten state, a solution state, or a slurry state at a temperature within a range of 30 to 350°C.

[0058] When the polypropylene-based resin is a mixture of unmodified polypropylene and modified polypropylene, the mixing ratio of the unmodified polypropylene and the modified polypropylene is not particularly limited and may be any ratio.

[0059] The weight average molecular weight of polypropylene resin is 2.0×10 5 ~3.5×10 5 , preferably 2.2×10 5 ~3.2×10 5 , more preferably 2.3×10 5 ~3.0×10 5 Polypropylene resins with a weight-average molecular weight within the above-mentioned range are generally not used in films due to their fragility. However, the PTP cover material of this embodiment utilizes this fragility to achieve a cover material with excellent ejection properties. Furthermore, by using a polypropylene resin with a weight-average molecular weight within the above-mentioned range, it is not necessary to degrade the propylene resin by irradiation with radiation, as in Patent Document 1. Therefore, it is possible to avoid the generation of unpleasant odors caused by resin decomposition during radiation exposure, reduced recyclability due to crosslinking of the reinforcing resin layer, and reduced sealing properties.

[0060] The weight average molecular weight can be measured using gel permeation chromatography (hereinafter also referred to as "GPC"), and specifically, can be measured by the method described in the Examples below.

[0061] The polypropylene resin content is preferably 60-100% by mass, more preferably 70-95% by mass, and even more preferably 75-90% by mass, based on 100% by mass of the PTP cover material. When the polypropylene resin content is within this range, good ejection properties tend to be exhibited. Furthermore, a polypropylene resin content of 100% by mass, in particular, results in a cover material with excellent recyclability.

[0062] The PTP cover material of the present embodiment may be a laminate having a layer containing the above-mentioned polypropylene-based resin (hereinafter also referred to as a “low-molecular-weight polypropylene-based resin layer”).

[0063] As other layers laminated on the low molecular weight polypropylene resin layer, for example, there can be mentioned: a sealing layer for improving the sealing with the PTP substrate; an adjustment layer for adjusting the physical properties of the cover material such as strength and ejection properties; a reinforcement layer for preventing film rupture during packaging; a barrier layer for improving gas barrier properties, etc.

[0064] The number of layers is not particularly limited, but is preferably 2 to 5 layers, more preferably 2 to 3 layers, from the viewpoint of a balance among strength, ejection properties, water vapor barrier properties, sealing properties, and recyclability.

[0065] When the total thickness of the PTP cover material is taken as 100%, the thickness of the low molecular weight polypropylene resin layer is preferably 60 to 95%, more preferably 70 to 95%, and even more preferably 75 to 90%. When the thickness of the low molecular weight polypropylene resin layer falls within this range, good ejection properties and water vapor barrier properties tend to be exhibited.

[0066] In one embodiment, the PTP cover material of the present embodiment may include: a layer containing the polypropylene resin; and at least one surface layer containing a polyethylene resin, a polypropylene resin, or a polyolefin elastomer.

[0067] The surface layer can be any one of the surface layer on the substrate side bonded to the substrate and the surface layer (outermost layer) on the outside, or both. For example, the surface layer on the outside can be used as a reinforcing layer for preventing film rupture during packaging. In addition, the heat sealability is excellent by comprising polyethylene resin, polypropylene resin or polyolefin elastomer, and since these resins can be co-extruded, it is not necessary to apply an emulsion type heat sealant, and unpleasant odor will not be produced even under high temperature conditions, so it is suitable as the surface layer on the substrate side bonded to the substrate. Wherein, in particular, for the reason of excellent low temperature sealing, it is preferably a layer comprising a polyolefin elastomer, and from the aspect of recyclability, it is preferably a layer comprising a polypropylene resin so that the PTP cover material as a whole is composed of a polypropylene resin.

[0068] When the thickness of the entire PTP cover material is taken as 100%, the thickness of the surface layer is preferably 5-40%, more preferably 5-30%, and even more preferably 10-25%. When the thickness of the surface layer falls within this range, good heat sealing properties can be imparted without degrading ejection properties, preventing film rupture.

[0069] The polyethylene resin contained in the above-mentioned surface layer is not particularly limited and can be any one of an ethylene homopolymer or a copolymer of ethylene and other monomers, for example, ethylene homopolymer; ethylene-α-olefin copolymers such as ethylene-propylene copolymer, ethylene-butene copolymer, and ethylene-octene copolymer; ethylene-(meth)acrylate copolymers such as ethylene-ethyl acrylate copolymer, ethylene-butyl acrylate copolymer, and ethylene-ethyl acrylate-methyl methacrylate copolymer; ethylene-vinyl acetate copolymer, etc. Among them, since the lower the density, the more the low-temperature sealing property tends to improve, low-density ethylene-α-olefin copolymers are preferred. In addition, from the aspect of environmental protection, it can be bio-polyethylene. In addition, the polyethylene resin can be used alone or in combination of two or more.

[0070] The method for producing the polyethylene resin is not particularly limited, and polymerization can be carried out using a known catalyst such as a single-site catalyst or a multi-site catalyst.

[0071] When the PTP cover material is 100% by mass, the polyethylene resin content is preferably 5 to 40% by mass, more preferably 5 to 30% by mass, and even more preferably 10 to 25% by mass. When the polyethylene resin content is within the above range, good heat sealing properties can be imparted without deteriorating ejection properties, and film rupture can be prevented.

[0072] Examples of the polypropylene resin contained in the surface layer include the same types as those for the low-molecular-weight polypropylene resin. Among them, a low-density propylene-α-olefin copolymer is preferred because of its excellent low-temperature sealing properties.

[0073] The molecular weight of the polypropylene resin is not particularly limited, but is preferably higher than the molecular weight of the polypropylene resin contained in the low molecular weight polypropylene resin layer. For example, a polypropylene resin having a melt flow rate (MFR, measured according to ASTM D-1238 at 230°C and a load of 2.16 kgf) of 3 to 15 g / 10 minutes can be used.

[0074] The polypropylene-based resin may be used alone or in combination of two or more.

[0075] Polyolefin-based elastomers are low-crystalline or amorphous olefin-based polymers having a crystallinity of 50% or less. Examples of monomers (olefins) of polyolefin-based elastomers include α-olefins such as ethylene, propylene, 1-butene, isobutylene, 1-pentene, 1-hexene, 4-methyl-1-pentene, 3-methyl-1-butene, 2-methyl-1-butene, 1-hexene, 1-octene, 1-decene, and 1-dodecene, and cyclic olefins such as cyclobutene, cyclopentene, and cyclohexene.

[0076] Among these, polypropylene-based elastomers with a low melting point (55-90°C) are preferred due to their excellent low-temperature sealing properties. Alternatively, bio-polyolefin-based elastomers may be used from an environmental perspective. Polyolefin-based elastomers may be used alone or in combination of two or more.

[0077] The method for producing the polyolefin-based elastomer is not particularly limited, and polymerization can be carried out using a known catalyst such as a single-site catalyst or a multi-site catalyst.

[0078] When the PTP cover material is 100% by mass, the content of the polyolefin elastomer is preferably 5 to 40% by mass, more preferably 5 to 30% by mass, and even more preferably 10 to 25% by mass. When the content of the polyolefin elastomer is within the above range, good heat sealing properties can be imparted without deteriorating ejection properties, and film rupture can be prevented.

[0079] In another embodiment, the PTP cover material of the present embodiment may include an adjustment layer for adjusting the physical properties of the cover material such as strength and ejection properties between the low molecular weight polypropylene resin layer and the surface layer.

[0080] When the thickness of the entire PTP cover material is set to 100%, the thickness of the adjustment layer is preferably 10 to 40%, more preferably 15 to 35%, and even more preferably 20 to 30%.

[0081] From the viewpoint of recyclability, it is preferable to use a polypropylene-based resin for the adjustment layer.

[0082] Examples of the types of polypropylene-based resins include the same types as those of the above-mentioned low-molecular-weight polypropylene-based resins.

[0083] The molecular weight of the polypropylene resin is not particularly limited, but is preferably higher than the molecular weight of the polypropylene resin contained in the low molecular weight polypropylene resin layer. For example, a polypropylene resin having a melt flow rate (MFR, measured according to ASTM D-1238 at 230°C and a load of 2.16 kgf) of 3 to 15 g / 10 minutes can be used.

[0084] The polypropylene-based resin may be used alone or in combination of two or more.

[0085] <Inorganic Matter>

[0086] The PTP cover material of the present embodiment may contain an inorganic substance in order to increase the number of fracture starting points and improve the ejection property.

[0087] The inorganic substance is not particularly limited, and examples thereof include amorphous aluminosilicate, silica, alumina, talc, kaolin, mica, wollastonite, clay, calcium carbonate, glass fiber, and aluminum sulfate.

[0088] When the PTP cover material is 100% by mass, the content of inorganic matter is preferably 0.1 to 3% by mass, more preferably 0.3 to 2% by mass, and even more preferably 0.5 to 1% by mass. When the content of inorganic matter is within the above range, the cover material can exhibit good ejection properties, contain few impurities, and have high recyclability.

[0089] The PTP cover material of this embodiment may contain additives commonly used in the relevant technical field, such as metal soaps to assist in the dispersion of the above-mentioned inorganic substances, colorants, plasticizers, antioxidants, heat stabilizers, ultraviolet absorbers, lubricants, antistatic agents, crystallization nucleating agents, etc.

[0090] Furthermore, the PTP cover material of the present embodiment may be subjected to treatments such as corona treatment, plasma treatment, ultraviolet treatment, and AC (anchor coating) treatment for improving printing characteristics.

[0091] In particular, white colorants or printing are preferred for the following reasons. In recent years, there has been a growing demand for PTP packaging for pharmaceuticals: in addition to printing conventional product name labels and instructions for use, barcodes containing various information such as product codes, expiration dates, manufacturing numbers, and quantities are also being printed to prevent medical accidents and ensure traceability. Using a cover material mixed with a white colorant or printed in white makes it easier to read the barcode because the portion without lines (the portion directly visible from the cover material) is white. Therefore, the color of the portion with the barcode lines (usually black) is different, making the barcode easier to read.

[0092] When the PTP cover material is taken as 100% by mass, the content of the additive is preferably 3% by mass or less.

[0093] The thickness of the PTP cover material of this embodiment is preferably 10 to 100 μm, more preferably 30 to 80 μm, and even more preferably 40 to 60 μm. A thickness of 10 μm or greater tends to exhibit tensile strength and water vapor barrier properties that withstand processing steps, while a thickness of 100 μm or less tends to exhibit good ejection properties.

[0094] The water vapor permeability of the PTP cover material of this embodiment is preferably 10 g / m 2 Less than 1 day, more preferably 8g / m 2 Less than 5g / m 2 When the water vapor permeability is within the above range, the contents such as pharmaceuticals can be prevented from being modified by water vapor, and can be stored for a long time.

[0095] The water vapor transmission rate of a PTP cover material can be adjusted, for example, by adjusting its thickness, the type of resin used, and the presence or absence of a barrier layer. Increasing the thickness of the PTP cover material or providing a barrier layer tends to reduce the water vapor transmission rate. Examples of barrier layers include resin layers made of ethylene-vinyl alcohol copolymers and cyclic olefins, and inorganic vapor-deposited layers such as aluminum, aluminum oxide, and silicon oxide. Furthermore, using a resin with high crystallinity can reduce the water vapor transmission rate of the PTP cover material.

[0096] The water vapor transmission rate is measured in accordance with JIS K7129 and is a value converted to a thickness of 40 μm. Specifically, it can be determined by the method described in the examples below.

[0097] The MD tensile strength of the PTP cover material of this embodiment is preferably 20 to 50 MPa, more preferably 20 to 45 MPa, and even more preferably 25 to 35 MPa. An MD tensile strength of 20 MPa or greater can prevent film breakage during processing. Furthermore, an MD tensile strength of 50 MPa or less can provide a PTP cover material with excellent ejection properties.

[0098] Examples of methods for controlling the MD tensile strength of the PTP cover material include changing the crystallinity of the resin or stretching the resin. Increasing the crystallinity or stretching the resin tends to increase the MD tensile strength.

[0099] The TD tensile strength of the PTP cover material of this embodiment is preferably 20 to 50 MPa, more preferably 20 to 45 MPa, and even more preferably 25 to 35 MPa. A TD tensile strength of 20 MPa or greater can prevent film breakage during processing. Furthermore, a TD tensile strength of 50 MPa or less can provide a PTP cover material with excellent ejection properties.

[0100] Examples of methods for controlling the TD tensile strength of the PTP cover material include changing the crystallinity of the resin or stretching the resin. Increasing the crystallinity or stretching the resin tends to increase the MD tensile strength.

[0101] The tensile strength in MD and TD can be measured in accordance with JIS K7127, and specifically, can be measured by the method described in the examples below.

[0102] The MD tensile elongation of the PTP cover material of this embodiment is preferably 15% or less, more preferably 11% or less, and even more preferably 9% or less. When the MD tensile elongation is within this range, the TD ejection property tends to be good (the cover material tends to be easily penetrated with cracks in the TD direction).

[0103] Examples of methods for controlling the MD tensile elongation of a PTP cover material include adjusting the crystallinity, MD orientation, fracture starting point, fragility, and breaking strength of the PTP cover material. Examples of methods for reducing MD tensile elongation include increasing the crystallinity of the PTP cover material, reducing the MD orientation, increasing the fracture starting point by adding inorganic substances, increasing fragility by increasing the proportion of a fragile layer such as the low molecular weight polypropylene resin layer, and reducing breaking strength by making the fragile layer softer.

[0104] The TD tensile elongation of the PTP cover material of this embodiment is preferably 15% or less, more preferably 11% or less, and even more preferably 9% or less. When the TD tensile elongation is within this range, the cover material tends to have good MD ejection properties (easily penetrate the cover material with cracks in the MD direction).

[0105] Examples of methods for controlling the TD tensile elongation of a PTP cover material include adjusting the crystallinity, TD orientation, fracture starting point, fragility, and fracture strength of the PTP cover material. To reduce the TD tensile elongation, methods include increasing the crystallinity of the PTP cover material, reducing the TD orientation, increasing the fracture starting point by adding inorganic substances, increasing fragility by increasing the proportion of a fragile layer such as the low molecular weight polypropylene resin layer, and reducing the fracture strength by making the fragile layer softer.

[0106] The tensile elongation in MD and TD can be measured in accordance with JIS K7127, and specifically, can be measured by the method described in the examples below.

[0107] The MD tensile modulus of the PTP cover material of this embodiment is preferably 300-1500 MPa, more preferably 400-1400 MPa, and even more preferably 600-1200 MPa. An MD tensile modulus of 300 MPa or greater can suppress film elongation and prevent print misalignment during printing on the PTP cover material. Furthermore, an MD tensile modulus of 1500 MPa or less can suppress hardening of the PTP cover material, preventing cracking during processing.

[0108] Examples of methods for controlling the MD tensile modulus of the PTP cover material include adjusting the crystallinity and MD orientation of the PTP cover material. If the crystallinity and MD orientation decrease, the MD tensile modulus tends to decrease.

[0109] The TD tensile modulus of the PTP cover material of this embodiment is preferably 1500 MPa or less, more preferably 1400 MPa or less, and even more preferably 1200 MPa or less. When the TD tensile modulus is 1500 MPa or less, the PTP cover material can be suppressed from hardening and cracking during processing can be prevented.

[0110] Examples of methods for controlling the TD tensile modulus of the PTP cover material include adjusting the crystallinity and MD orientation of the PTP cover material. If the crystallinity and MD orientation decrease, the TD tensile modulus tends to decrease.

[0111] The tensile modulus of elasticity in MD and TD can be measured in accordance with JIS K7127, and specifically, can be measured by the method described in the examples below.

[0112] The PTP cover material of this embodiment has a crystal heat of fusion of 70 J / g or greater, preferably 75 to 200 J / g, and more preferably 80 to 200 J / g, as measured by differential scanning calorimetry (DSC). When the crystal heat of fusion is within this range, the MD and TD tensile elongations, as well as the puncture elongation, tend to exhibit good ejection properties.

[0113] Methods for controlling the crystal fusion heat of a PTP cover material include, for example, methods for adjusting the cooling of the cover material during production, annealing after production, and the addition of a crystal nucleating agent. For example, the crystal fusion heat can be increased by using slow cooling when producing a PTP cover material by direct inflation, annealing after production, and adding a crystal nucleating agent.

[0114] In addition, the measurement of the heat of fusion of the crystal by differential scanning calorimetry (DSC) can be specifically carried out by the method described in the examples below.

[0115] The PTP cover material of this embodiment preferably has a crystallinity of 46% or greater, more preferably 47% or greater, and even more preferably greater than 48%, as measured by Fourier transform infrared spectrophotometry (FT-IR). When the crystallinity is within this range, the MD and TD tensile elongations, as well as the puncture elongation, are appropriate, demonstrating good ejection properties.

[0116] Methods for controlling the crystallinity of PTP cover materials include, for example, methods for adjusting the cooling of the cover material during production, annealing after production, and the addition of a crystal nucleating agent. For example, the crystallinity can be increased by slowly cooling the cover material by airing when producing the PTP cover material by direct inflation, annealing the cover material after production, and adding a crystal nucleating agent.

[0117] The crystallinity can be measured by FT-IR, specifically, by the method described in the Examples below, or similarly using a Raman spectrophotometer.

[0118] The MD orientation of the PTP cover material of this embodiment is preferably -0.035 to 0.035, more preferably -0.03 to 0.03, and even more preferably -0.02 to 0.02. When the MD orientation is within this range, the MD tensile elongation and TD tensile elongation tend to be within the appropriate range, the balance between MD and TD tensile elongation is excellent, and good ejection properties are exhibited.

[0119] Methods for controlling the MD orientation of PTP cover materials include, for example, adjusting the cooling of the cover material, the TD stretch ratio (BUR), or the timing during the production of the PTP cover material. For example, the MD orientation can be reduced by, for example, slowly cooling the cover material by ventilation, increasing the TD stretch ratio (BUR), or performing production by sequential secondary stretching when producing the PTP cover material by direct inflation.

[0120] The MD orientation degree can be measured using FT-IR, and specifically, can be measured by the method described in the examples below.

[0121] The MD orientation degree indicates the orientation in the MD relative to the TD. Therefore, the orientation in the MD relative to the thickness direction and the orientation in the TD relative to the thickness direction of the PTP cover material can be measured separately and calculated based on the measured results. In the case of a multi-layered PTP cover material, the thickest layer is likely to affect the properties of the PTP cover material. Therefore, the orientation degree of the thickest layer (or any of the thickest layers if there are two or more) can be measured.

[0122] In addition, the MD orientation degree can also be measured using a Raman spectrophotometer in the same manner as when using FT-IR.

[0123] In the load-displacement curve of the puncture test of the PTP cover material, the maximum load reduction per 0.1 mm displacement in the fracture area is preferably 3 to 20 N, more preferably 4 to 18 N, and even more preferably 5 to 15 N. PTP cover materials with a maximum load reduction of more than 20 N per 0.1 mm displacement are difficult to break when removing contents such as tablets from the PTP package, and tend to lack ejection properties. In addition, the maximum load reduction per 0.1 mm displacement is one of the factors that has the greatest impact on unsealing identification. If the maximum load reduction per 0.1 mm displacement is less than 3 N, it means that the PTP cover material is brittle, and almost no unsealing sound is produced when removing contents such as tablets, and the unsealing identification tends to be poor.

[0124] Figure 2 An example of a load-displacement curve obtained when a puncture test is performed on the PTP cover material of this embodiment is shown. Figure 2 In the case of PTP cover materials, the maximum load per 0.1mm displacement is reduced to 8N.

[0125] As a method for controlling the maximum load reduction per 0.1 mm displacement of the PTP cover material, for example, there is a method of adjusting the weight average molecular weight of the polypropylene resin, the thickness of the PTP cover material, and the reinforcing layer. If the weight average molecular weight of the polypropylene resin or the thickness of the PTP cover material is increased, or a reinforcing layer is provided, the maximum load reduction per 0.1 mm displacement can be increased.

[0126] It should be noted that the maximum load reduction per 0.1 mm displacement in the fracture region of the load-displacement curve can be specifically measured by the method described in the examples below.

[0127] The PTP cover material of this embodiment preferably has a puncture strength of 6 to 15 N, more preferably 7 to 13 N, and even more preferably 8 to 10 N. A puncture strength of 6 N or greater prevents damage to the PTP cover material due to external forces, such as during transport of the PTP package. Furthermore, a puncture strength of 15 N or less provides a PTP cover material with excellent ejection properties.

[0128] As a method for controlling the puncture strength of the PTP cover material, for example, there is a method of adjusting the weight average molecular weight of the polypropylene resin, the thickness of the PTP cover material, and the reinforcing layer. If the weight average molecular weight of the polypropylene resin or the thickness of the PTP cover material is increased, or a reinforcing layer is provided, the puncture strength tends to increase.

[0129] It should be noted that the puncture strength is a value converted to a thickness of 40 μm, and can be specifically determined by the method described in the Examples below.

[0130] The PTP cover material of this embodiment preferably has a puncture elongation of 1 to 4 mm, more preferably 1.2 to 3 mm, and even more preferably 1.5 to 2.5 mm. A puncture elongation of 1 mm or greater prevents damage to the PTP cover material due to external forces, such as during transport of the PTP package. Puncture elongation, like tensile elongation and ejection strength, is one of the factors that most significantly influence ejection performance. A puncture elongation of 4 mm or less produces a PTP cover material with excellent ejection performance.

[0131] As a method for controlling the puncture elongation of the PTP cover material, for example, there is a method of adjusting the weight average molecular weight of the polypropylene resin, the layer ratio of the PTP cover material, the crystallinity, the MD and TD orientation, etc. If the weight average molecular weight of the polypropylene resin is reduced, the proportion of the low molecular weight polypropylene resin is increased, the crystallinity is increased, or the MD and TD orientation are reduced, the puncture elongation tends to decrease.

[0132] It should be noted that the puncture elongation rate can be specifically measured by the method described in the following examples.

[0133] <Manufacturing Method of Cover Material for PTP>

[0134] The manufacturing method of the cover material for PTP is not particularly limited. As an example, the direct blow-up method can be cited. In this method, the above-mentioned constituent materials are extruded into a tubular shape using a known melt extruder equipped with an annular die, and then air is directly blown in for stretching. When the cover material for PTP is a laminate composed of two or more layers, the co-extrusion direct blow-up method is preferred.

[0135] The outline of the method for manufacturing the cover material for PTP as a laminate by the co-extrusion direct blow-up method will be described below.

[0136] The resin or resin composition as the constituent material of each layer is melted above the melting temperature of the resin, and using the same number of extruders as the number of layers, each layer is extruded simultaneously. The resin or resin composition of each extruded layer is sent to the annular die through a feed pipe, and a tubular film in which each layer is laminated is formed by the annular die. Then, a gas (air, nitrogen, etc.) is blown into the film to form a bubble, and the film is stretched in the MD and TD directions, thereby manufacturing the cover material for PTP.

[0137] The MD draw ratio (DDR) of the film is preferably 8 to 23 times, more preferably 10 to 20 times. When the MD draw ratio is 8 times or more, the pulsation of the bubble is suppressed, and the stretching tends to become stable. In addition, when the MD draw ratio is 23 times or less, a cover material with an appropriate MD orientation degree, an excellent balance between the MD and TD orientation degrees, and good ejection properties can be obtained.

[0138] In addition, the TD draw ratio (BUR) of the film is preferably 1.3 to 4 times, more preferably 1.5 to 2.5 times. When the TD draw ratio is 1.3 times or more, a cover material with an appropriate MD orientation degree, an excellent balance between the MD and TD orientation degrees, and good ejection properties can be obtained. In addition, when the TD draw ratio is 4 times or less, the pulsation of the bubble is suppressed, and the stretching tends to become stable.

[0139] It should be noted that the MD draw ratio can be adjusted by the speed of the pinch rolls, and the TD draw ratio can be adjusted by the volume of air blown into the film.

[0140] The stretching temperature of the film is preferably 70 to 160°C, more preferably 80 to 120°C. When the stretching temperature is 70°C or higher, the crystallinity of the lid material is likely to be within an appropriate range, and a lid material with excellent balance of MD and TD orientation degrees and good ejection properties can be obtained. In addition, when the stretching temperature is 160°C or lower, there is a tendency for stretching to become stable.

[0141] It should be noted that the stretching temperature is the temperature actually measured on the film surface at a position 32 cm vertically away from the discharge surface of the annular die toward the downstream side of the manufacturing process using a non-contact thermometer, and can be adjusted by the wind speed of the ventilation for cooling the molten resin, the discharge amount of the molten resin, DDR, etc.

[0142] <PTP package>

[0143] The PTP package of the present embodiment is characterized in that it includes the PTP lid material of the present embodiment and a bottom material having a recess for accommodating the contents.

[0144] Figure 1 It is a cross-sectional view showing an example of a PTP package provided with the PTP lid material of the present embodiment. The PTP package 1 includes a PTP lid material 2 and a bottom material 3. The bottom material 3 has a pocket-shaped recess 4 and a flange portion 5 that adheres to the lid material 2, and the contents 6 are filled in the recess 4.

[0145] <Bottom material>

[0146] As the bottom material constituting the PTP package of the present embodiment, for example, a sheet containing a known synthetic resin such as a polyvinyl chloride-based resin, a polyvinylidene chloride-based resin, a polyolefin-based resin (such as a polyethylene-based resin, a polypropylene-based resin, an ethylene-vinyl alcohol copolymer resin, a cyclic olefin resin, etc.), polychlorotrifluoroethylene, or a polyester can be cited, and a sheet composed of these synthetic resins is preferred. Among them, from the aspect of recyclability, a sheet containing a polyethylene-based resin, a polypropylene-based resin, or a cyclic olefin resin is preferred, and most preferably, like the PTP lid material, it contains a polypropylene-based resin.

[0147] From the aspect of the breadth of the molding condition range for vacuum or pressure molding of the pocket-shaped recess of the bottom material, the heat distortion temperature of the bottom material is preferably 50 to 160°C, more preferably 80 to 120°C according to JIS K7191.

[0148] Regarding the shape of the bottom material, as long as it has a recess for accommodating the contents, there is no particular limitation. The shapes of the bottom surface portion and the opening portion of the recess can be rectangular (square, rectangle, triangle, etc.) or circular (circle, ellipse, etc.), and the corners of the rectangle can also have a curvature.

[0149] The size of the base material is not particularly limited and can be appropriately determined according to the size, number, etc. of the content. For example, the depth of the recess can be 1 to 15 mm, preferably 2 to 10 mm. In addition, particularly when the shapes of the opening part and the bottom part of the recess are circular, the diameter of the opening part can be, for example, 5 to 150 mm, preferably 10 to 100 mm, and the diameter of the bottom part can be 5 to 20% smaller than the diameter of the opening part respectively.

[0150] In addition, the part other than the recess, that is, the flange part, is not particularly limited and can be provided in a manner that extends in a direction orthogonal to the depth direction of the recess.

[0151] As the average width of the flange part, for example, it can be 2 to 100 mm, preferably 4 to 50 mm.

[0152] The thickness of the base material 1 is not particularly limited. For example, it can be 100 to 500 μm, preferably 150 to 300 μm.

[0153] <Method for manufacturing a PTP package>

[0154] The PTP package of the present embodiment can be manufactured by overlapping the surface (flange part) of the base material and the surface of the lid material and performing heat sealing.

[0155] Regarding the heat sealing temperature, for example, 100 to 160 °C can be cited. From the aspect of not easily generating burn marks on the content, it is preferably 100 to 140 °C. In addition, the heat sealing time can be cited, for example, 0.05 to 3 seconds. From the aspects of not easily generating burn marks on the content and obtaining sufficient sealing strength, it is preferably 0.2 to 1 second. In addition, the heat sealing pressure can be cited, for example, 0.2 to 0.6 MPa. From the aspects of not easily generating burn marks on the content and obtaining sufficient sealing strength, it is preferably 0.3 to 0.5 MPa.

[0156] As the molding machine used in the molding of the PTP package in the present embodiment, for example, a roll-type sealing molding machine that sandwiches the lid material and the base material between a heat sealing roll and a sealing lower roll for heat sealing can be cited; a flat plate sealing molding machine that has a heating mold with flat plates on the upper and lower sides and sandwiches the lid material and the base material between the molds for molding, etc. Among them, it is preferable to use a flat plate sealing molding machine that can easily obtain sufficient sealing strength.

[0157] Examples

[0158] Specific examples and comparative examples are given below to illustrate the present embodiment, but the present embodiment is not limited to these.

[0159] The raw materials used in the examples and comparative examples are as described below.

[0160] <Polypropylene-based resin (PP)>

[0161] PP1: Polypropylene (manufactured by Sun Allomer Co., Ltd., PLB00A, weight average molecular weight: 2.2×10 5 )

[0162] PP2: Polypropylene (manufactured by Sun Allomer Co., Ltd., PLA00A, weight average molecular weight: 2.6×10 5 )

[0163] PP3: Polypropylene (manufactured by Sun Allomer Co., Ltd., VS700A, weight average molecular weight: 3.8×10 5 )

[0164] PP4: Polypropylene (manufactured by Sun Allomer Co., Ltd., PL500A, weight average molecular weight: 6.0×10 5 )

[0165] <Polyethylene resin (PE)>

[0166] ·Polyethylene (manufactured by Ube Maruzen Polyethylene Co., Ltd., Umerit 0520F)

[0167] <Polyolefin Elastomer (TPO)>

[0168] Propylene-α-olefin copolymer (manufactured by Mitsui Chemicals, Inc., TAFMER XM7070)

[0169] <Ethylene-vinyl acetate copolymer saponified product (EVOH)>

[0170] Ethylene-vinyl acetate copolymer saponified product (Mitsubishi Chemical Corporation, Soarnol DC3203)

[0171] <Adhesive resin>

[0172] Acid-modified polyolefin composition (Mitsui Chemicals, Inc., Admer NF587)

[0173] <Polystyrene resin (PS)>

[0174] Polystyrene (PS Japan Co., Ltd., PSJ-Polystyrene G9305)

[0175] <Inorganic Matter>

[0176] Amorphous aluminosilicate (Silton JC-30, manufactured by Mizusawa Chemical Industry Co., Ltd.)

[0177] <Substrate>

[0178] PP: A single-layer polypropylene sheet (SUMILITE NS-3450 (300 μm thickness, manufactured by SUMITOMO BAKELITE Co., Ltd.) was molded into a substrate having a depth of 4 mm, a circular opening with a diameter of 10 mm, a circular recess with a diameter of 8 mm at the bottom, and a flange with an average width of 10 mm extending perpendicular to the depth. The openings were arranged in perpendicular vertical and horizontal rows, with the center-to-center distance between the openings being 20 mm in the vertical direction and 20 mm in the horizontal direction.

[0179] PP / PE: A 300 μm thick multilayer sheet was prepared by coextrusion direct inflation, with polypropylene (PL500A, manufactured by Sun Allomer Co., Ltd.), polypropylene (PC540R, manufactured by Sun Allomer Co., Ltd.), and polyethylene (Umerit 0520F, manufactured by Ube Maruzen Polyethylene Co., Ltd.) layered in that order. The polyethylene side of this multilayer sheet served as the heat-sealed surface, and molding was performed in the same manner as the polypropylene single-layer sheet.

[0180] PVC: a polyvinyl chloride single-layer sheet (SUMILITE VSS-F110 (thickness 250 μm) manufactured by SUMITOMO BAKELITE CO., LTD.) Molded in the same manner as the above-mentioned polypropylene single-layer sheet.

[0181] The measurement and evaluation methods used in Examples and Comparative Examples are described below.

[0182] (1) Weight average molecular weight

[0183] The weight average molecular weight of the polypropylene resin used for the PTP cover material in Examples and Comparative Examples was measured in the following manner.

[0184] First, 1,2,4-trichlorobenzene was added to the sample to a concentration of 1 mg / mL. After standing at 160°C for 30 minutes, the sample was shaken at 160°C for 1 hour to dissolve the sample. The solution was filtered with a 0.5 μm PTFE filter and the weight average molecular weight in terms of polystyrene was measured using GPC (manufactured by Agilent, PL-GPC220). It should be noted that the column used in the measurement was a column consisting of two TSK-gel GMH columns manufactured by Tosoh Corporation. HR -H(20)HT (7.8 mm×30 cm), and the column temperature was set at 160°C.

[0185] (2) Water vapor transmission rate

[0186] The water vapor transmission rate of the PTP cover materials obtained in the examples and comparative examples was measured using a water vapor transmission rate measuring device (PERMATRAN-W Model 398 manufactured by MOCON). The water vapor transmission rate (g / m2) was measured at 38°C and 90% RH in accordance with JIS K7129. 2 ·day), converted to 40μm thickness.

[0187] (3) Tensile strength, tensile elongation, and tensile modulus

[0188] The PTP covering materials obtained in Examples and Comparative Examples were measured for tensile strength, tensile elongation, and tensile modulus in MD and TD, respectively, in accordance with JIS K7127.

[0189] Cut out a long strip of test piece (length 150mm × width 10mm) from the PTP cover material. Install the ends of the test piece on a precision universal testing machine (manufactured by Shimadzu Corporation, Autograph) with a distance between the chucks of 50mm. Move at a speed of 200mm / min between the chucks. At this time, measure the maximum load and maximum elongation required for fracture, which are respectively used as tensile strength (MPa) and tensile elongation (%). In addition, the load at 2% elongation is used as tensile modulus (MPa). Average the values ​​measured on 10 test pieces as the tensile strength, tensile elongation and tensile modulus of the PTP cover material.

[0190] (4) Crystallization heat of fusion

[0191] A sample (5-10 mg) was cut out from the PTP cover material obtained in the examples and comparative examples, and measured using a differential scanning calorimeter (DSC) (manufactured by Hitachi High-Tech Science, DSC7000X) under a nitrogen atmosphere using indium as a heat standard. As a heating program, the sample was heated from 0°C to 200°C at a heating rate of 10°C / min. For the endothermic peak caused by melting in the obtained heat flow curve, the straight line extrapolated from the high temperature side was used as the baseline to determine the crystal melting heat (J / g). It should be noted that when there are two or more endothermic peaks caused by melting, the sum of the crystal melting heats is taken as the crystal melting heat of the PTP cover material.

[0192] (5) Crystallinity

[0193] The crystallinity (%) of the PTP cover materials obtained in the examples and comparative examples was measured using a Fourier transform infrared spectrophotometer (FT / IR4100 manufactured by JASCO Corporation). The crystallinity was calculated using the 973 cm -1 (peaks from crystalline and amorphous) and 998 cm-1 The absorbance (peak derived from crystals) (hereinafter, absorbance represents the height of the peak) was determined by the following formula.

[0194] Crystallinity = 0.56 × absorbance (998 cm -1 ) / absorbance(973cm -1 )×100

[0195] It should be noted that the cumulative number of measurements is 16 times and the resolution is 4 cm -1 The average value of the values ​​measured on 5 test pieces was taken as the crystallinity.

[0196] (6) MD orientation

[0197] The MD orientation of the PTP cover materials obtained in the examples and comparative examples was measured using a Fourier transform infrared spectrophotometer (FT / IR4100, manufactured by JASCO Corporation). The PTP cover materials were measured using a grating polarization element at 0° (MD) and 90° (TD). The 973 cm-1 OD of each polypropylene resin was used. -1 The MD orientation degree was calculated by the following formula.

[0198] Dichroic ratio (R) = absorbance (MD) / absorbance (TD)

[0199] MD orientation = (R-1) / (R+2)×1.17

[0200] It should be noted that the cumulative number of measurements is 16 times and the resolution is 4 cm -1 The average value of the values ​​measured on 5 test pieces was taken as the MD orientation degree.

[0201] (7) Puncture strength and puncture elongation

[0202] The PTP covering materials obtained in Examples and Comparative Examples were measured for puncture strength and puncture elongation in the following manner.

[0203] The PTP cover material is fixed in a state of being laid on a frame with a diameter of 10 mm. A needle with a diameter of 4 mm and a flat front end is installed in a precision universal testing machine (manufactured by Shimadzu Corporation, Autograph) and pressed into the fixed PTP cover material to perform a puncture test. The measurement is carried out in an environment of temperature 23°C and humidity 50% RH, and the moving speed of the needle is set to 50 mm / minute. The maximum load applied to the needle when damage occurs is taken as the puncture strength (N), converted into a thickness of 40 μm. In addition, the depth of the front end position of the needle when damage occurs (the displacement from the position after the needle contacts the fixed PTP cover material to the position when damage occurs) is taken as the puncture elongation (mm). The values ​​obtained by measuring 5 test pieces are averaged and taken as the puncture strength and puncture elongation of the PTP cover material.

[0204] (8) The maximum load at fracture during puncture test is reduced

[0205] The PTP covering materials obtained in Examples and Comparative Examples were measured for the reduction in load at break in the puncture test in the following manner.

[0206] The PTP cover material is fixed in a state of being laid on a frame with a diameter of 10 mm. A needle with a diameter of 4 mm and a flat front end is installed in a precision universal testing machine (manufactured by Shimadzu Corporation, Autograph) and pressed into the fixed PTP cover material to perform a puncture test. The measurement is carried out in an environment of temperature 23°C and humidity 50% RH, and the moving speed of the needle is set to 50 mm / min. The maximum value of the load reduction per 0.1 mm displacement in the fracture area of ​​the obtained load-displacement curve (in the load reduction associated with the occurrence of breakage) is determined. The values ​​measured on 5 test pieces are averaged as the maximum load reduction per 0.1 mm displacement of the PTP cover material.

[0207] (9) Sealing strength

[0208] The sealing strength of the PTP cover materials obtained in Examples and Comparative Examples was measured in the following manner.

[0209] First, the PTP cover material and the base material are heat-sealed using a heat seal tester (manufactured by TESTER SANGYO). The sealing temperature at this time is set to 140°C, the sealing time is 2 seconds, and the sealing pressure is 0.25MPa. Thereafter, a long strip of test piece is cut out (the length of the PTP cover material and the base material is 40mm (80mm in total) × 15mm in width). The end of the test piece is installed in a manner such that the sealing portion is arranged between the chucks of a precision universal testing machine (manufactured by Shimadzu Corporation, Autograph) with a distance of 30mm between the chucks. Move at a moving speed of 200mm / minute between the chucks, implement a 180° peel test, and use the maximum load until the sealing portion is completely peeled off as the sealing strength (N / 15mm). The values ​​obtained by measuring 10 test pieces are averaged and used as the sealing strength of the PTP cover material.

[0210] (10) Ejection

[0211] The puncture elongation of the PTP cover materials obtained in Examples and Comparative Examples and the presence or absence of interlayer delamination when the cover material of the PTP package was pierced were summarized and evaluated for ejection properties according to the following evaluation criteria.

[0212] [Evaluation Criteria]

[0213] ◎ (Excellent): The puncture elongation is less than 2.6 mm, and no delamination or partial breakage occurs when the lid material of the PTP package is penetrated.

[0214] ○ (good): The puncture elongation is 2.6 mm or more and less than 3.2 mm, and no interlayer delamination or partial breakage occurs when the lid material of the PTP package is penetrated.

[0215] × (poor): The puncture elongation was 3.2 mm or more, and interlayer delamination or partial breakage occurred when the lid material of the PTP package was penetrated.

[0216] (11) Opening identification

[0217] The PTP packages obtained in the Examples and Comparative Examples were measured using a standard noise meter (NA-29, manufactured by RION Co., Ltd.) to measure the sound produced when the lid material was pierced and the contents were removed. The following evaluation criteria were used to evaluate the open seal identification. The distance between the microphone tip and the pierced lid material was set at 30 mm, and the average value of 10 measurements was used.

[0218] [Evaluation Criteria]

[0219] ◎(Excellent): 80dB or above

[0220] ○ (Good): 60dB or more, less than 80dB

[0221] × (bad): less than 60dB, or cannot penetrate the cover material

[0222] (12) Membrane odor

[0223] The PTP caps obtained in the examples and comparative examples were tested for the presence of membrane odor using dynamic headspace GC / MS (DHS manufactured by Gestel, GC-7890MSD-5977B manufactured by Agilent). Sample preparation involved adding 2 g of PTP cap to a 20 mL glass bottle and heating at 50°C for 30 minutes. During this time, 1950 mL of nitrogen gas was used to adsorb the odor components contained in the PTP cap onto an activated carbon-based adsorbent (Carbopack B / Carbopack X manufactured by Agilent). After heating, the gas adsorbed by the activated carbon-based adsorbent was desorbed at 300°C in the TDU section using a heated desorption device (TDU2 manufactured by Gestel) installed at the GC / MS inlet. During this time, the gas was re-concentrated at -40°C in the CIS unit, heated again to 300°C, and measured by GC / MS. Unpleasant odor components of PTP lid materials include acetic acid, butyric acid, and acetylacetone. The membrane odor was evaluated as follows based on the detected amounts of butyric acid and acetic acid.

[0224] [Evaluation Criteria]

[0225] ○ (Excellent): The detected amount of butyric acid is less than 0.01 ppm, and the detected amount of acetic acid is less than 0.1 ppm.

[0226] × (bad): The detected amount of butyric acid is 0.01 ppm or more, or the detected amount of acetic acid is 0.1 ppm or more.

[0227] [Example 1]

[0228] A two-layer PTP cover material was produced by laminating a polypropylene resin (PP) layer (first layer) and a polyolefin elastomer (TPO) layer (second layer) using a coextrusion direct inflation method.

[0229] Specifically, the resin pellets used as the raw materials for each layer are melted above the resin's melting temperature and extruded simultaneously using two or more extruders. The extruded resins for each layer are fed through a feed tube to an annular die, where they are stacked to form a tubular laminated film. The thickness ratio of the PP layer to the TPO layer is adjusted to 80:20.

[0230] Next, the laminated film was stretched by blowing air into it, thereby obtaining a PTP cover material having a thickness of 40 μm. The stretching ratio was set to 30 times in MD and 2 times in TD, and the stretching temperature was set to 61°C.

[0231] The tablets were filled into the recesses of the PP base material, and the PP base material and the cover material (TPO layer side) were bonded by heat sealing using an Eshin Pack Sealer (manufactured by Eshin Pack Industries, Ltd., semi-automatic OS) to obtain a PTP package.

[0232] The heat sealing conditions were set to a temperature of 140° C., a pressure of 0.4 MPa, and a time of 1 second.

[0233] Table 1 shows the measurement and evaluation results of various physical properties.

[0234] [Examples 2 to 5, Comparative Examples 1 to 3]

[0235] In Examples 2 to 5 and Comparative Examples 1 to 3, PTP lid materials were produced in the same manner as in Example 1 except that the raw materials, compounding amounts, etc. were changed as shown in Table 1, thereby obtaining PTP packaging bodies.

[0236] It should be noted that, in the first layer of Example 5, amorphous aluminosilicate was mixed into the polypropylene resin (PP2) before extrusion.

[0237] Table 1 shows the detailed conditions and the measurement and evaluation results of various physical properties.

[0238] [Example 6]

[0239] In Example 6, a two-layer film consisting of a first layer and a second layer was produced in the same manner as in Example 1, with the raw materials and compounding amounts modified as shown in Table 1. The first layer surface was then corona treated, and a 10 nm thick inorganic vapor-deposited aluminum layer (third layer) was formed by vacuum deposition to produce a PTP cover material. The PP base material and the cover material (TPO layer side) were bonded together in the same manner as in Example 1 to produce a PTP package.

[0240] Table 1 shows the detailed conditions and the measurement and evaluation results of various physical properties.

[0241] [Comparative Example 4]

[0242] In Comparative Example 4, a two-layer film consisting of a first layer and a second layer was prepared in the same manner as in Example 1, with the raw materials and compounding amounts modified as shown in Table 1. Subsequently, the film was irradiated with electron beams at an accelerating voltage of 250 kV and a dose of 60 kGy, as described in Patent Document 1, to produce a PTP cover material. A PP / PE base material (PE layer side) and a cover material (PE layer side) were bonded together in the same manner as in Example 1 to produce a PTP package.

[0243] Table 1 shows the detailed conditions and the measurement and evaluation results of various physical properties.

[0244] [Comparative Example 5]

[0245] Referring to Patent Document 4, a three-layer laminated film was produced using a coextrusion direct inflation method, comprising a first layer of an ethylene-vinyl acetate copolymer saponified product (EVOH), a second layer of an acid-modified polyolefin composition, and a third layer of a polystyrene resin (PS). The thickness ratio of the layers was adjusted to 20:10:70 (EVOH layer: acid-modified polyolefin composition layer: PS layer), resulting in a total thickness of 40 μm.

[0246] Next, an ethylene vinyl acetate (EVA) emulsion heat sealant was applied to the PS layer of the resulting laminated film to a dry film thickness of 9 μm to produce a PTP cover material. Subsequently, the PVC base material and the cover material (heat sealant side) were bonded together in the same manner as in Example 1 to produce a PTP package.

[0247] Table 1 shows the detailed conditions and the measurement and evaluation results of various physical properties.

[0248] [Comparative Example 6]

[0249] Referring to Patent Document 5, two types of polypropylene (PP3 and PP4) were laminated by coextrusion, and the film extruded from the die was cooled with cold water to produce a two-layer unstretched laminated film. Next, the unstretched laminated film was heated to 140°C, stretched 4 times in the MD direction, and then a propylene-α-olefin copolymer (TPO) was laminated on the PP3 layer by extrusion lamination to produce a three-layer laminated film. Next, a tenter-type stretching machine was used to stretch 5 times in the TD direction at 140°C to produce a PTP cover material. At this time, the thickness ratio of each layer was adjusted to PP4:PP3:TPO=20:10:70, so that the total thickness was 40μm. The PP base material and the cover material (TPO layer side) were bonded in the same manner as in Example 1 to obtain a PTP packaging body.

[0250] Table 1 shows the detailed conditions and the measurement and evaluation results of various physical properties.

[0251]

[0252] Industrial Applicability

[0253] The PTP package cover of the present invention can be suitably used for packaging pharmaceuticals such as tablets and capsules, or foods such as candies and chocolates.

[0254] Explanation of symbols

[0255] 1PTP packaging

[0256] 2PTP cover material

[0257] 3 substrate

[0258] 4 recesses

[0259] 5 Flange

[0260] 6 Contents

Claims

1. A PTP cover material, characterized in that: It contains a weight average molecular weight of 2.0×10 5 ~3.5×10 5 The polypropylene resin has a crystal melting heat of 70 J / g or more based on a differential scanning calorimeter DSC, MD tensile elastic modulus is 300MPa to 1500MPa, TD tensile elastic modulus is less than 1500MPa, The MD orientation degree is -0.035 to 0.

035.

2. The PTP cover material according to claim 1, wherein In the load-displacement curve of the puncture test of the PTP cover material, the maximum load per 0.1 mm displacement in the fracture region decreased to 3N to 20N.

3. The PTP cover material according to claim 1 or 2, wherein: Thickness is 10μm~100μm, water vapor permeability is 10g / m 2 · days or less, the tensile strength is 20 MPa to 50 MPa in both MD and TD, and the tensile elongation is 15% or less in both MD and TD. The PTP cover material according to claim 1 or 2, comprising 0.1% by mass to 3% by mass of an inorganic substance. 5 . The PTP covering material according to claim 1 , comprising: a layer comprising the polypropylene resin; and at least one surface layer comprising a polyethylene resin, a polypropylene resin, or a polyolefin elastomer.

6. The PTP cover material according to claim 1, wherein The weight average molecular weight of the polypropylene resin is 2.2×10 5 ~3.0×10 5 .

7. The PTP cover material according to claim 1, wherein The crystal melting heat is 80 J / g to 200 J / g.

8. The PTP cover material according to claim 2, wherein The maximum load per 0.1mm displacement is reduced to 4N~18N.

9. The PTP cover material according to claim 2, wherein: The maximum load is reduced to 5N to 15N per 0.1mm displacement.

10. The PTP cover material according to claim 3, wherein The thickness is 30μm to 80μm.

11. The PTP cover material according to claim 3, wherein Water vapor transmission rate is 8g / m 2 · Days or less.

12. The PTP cover material according to claim 3, wherein The tensile strength is 25 MPa to 35 MPa in both MD and TD.

13. The PTP cover material according to claim 3, wherein The tensile elongation in both MD and TD was less than 11%.

14. The PTP cover material according to claim 4, wherein The content of the inorganic matter is 0.3% to 2% by mass.

15. The PTP cover material according to claim 5, wherein When the thickness of the entire PTP cover material is set to 100%, the thickness of the polypropylene-based resin layer is 70% to 95%.

16. The PTP cover material according to claim 1 or 2, wherein: The crystallinity measured by Fourier transform infrared spectrophotometer is 46% or more.

17. The PTP cover material according to claim 1 or 2, wherein: The puncture strength is 6N~15N.

18. The PTP cover material according to claim 1 or 2, wherein: The puncture elongation is 1mm to 4mm.

19. A PTP packaging body, characterized in that: The PTP cover material comprises the PTP cover material according to any one of claims 1 to 18, and a base material having a recessed portion for accommodating contents.

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