A composition containing ergothioneine and a silicone elastomer active and uses thereof

Abstract

The application discloses a composition containing ergothioneine and a silicone elastomer active, which comprises 0.001-10% of ergothioneine and 0.05-20% of the silicone elastomer active; the silicone elastomer active comprises a dimethicone / vinyl dimethicone crosspolymer and / or a dimethicone crosspolymer. The composition containing ergothioneine and the silicone elastomer active provided by the application adopts a specific dosage ratio of ergothioneine and the silicone elastomer active, can reduce the trimethylamine odor generated by ergothioneine under conditions of high temperature, light and normal temperature, and makes the ergothioneine more widely applied in cosmetics. When the composition containing ergothioneine and the silicone elastomer active is applied to cosmetics, a good skin feel adjusting effect can be achieved.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and more particularly to a composition containing ergothioneine and a silica elastomer active ingredient and its application. Background Technology

[0002] L-Ergothioneine (EGT) is a natural antioxidant that can protect DNA proteins from oxidative damage. At the same time, as a rare sulfur-containing amino acid (L-thiol histidine trimethyl inner salt), it is a naturally occurring cell protectant and antioxidant in the human body, with anti-photoaging and antioxidant effects.

[0003] Ergothioneine can be transported to the mitochondria, vital "energy factories," via the skin cell transporter OCTN1, where it exerts its antioxidant function, thereby inhibiting DNA damage and effectively protecting against UV damage. Ergothioneine also possesses the ability to scavenge free radicals, reduce lipid peroxidation, and promote the body's own antioxidant enzymes (such as the well-known superoxide dismutase (SOD)). Furthermore, ergothioneine protects human fibroblasts and enhances their survival by reducing the degradation of matrix metalloproteinase-1 (MMP-1) and increasing the production of type I collagen.

[0004] Ergothioneine, a powerful antioxidant, is widely used in cosmetics. However, we have found that when the amount of ergothioneine added to cosmetics exceeds 0.001%, a trimethylamine odor is produced, causing an unpleasant experience for consumers and limiting its application. Summary of the Invention

[0005] In order to overcome the shortcomings of the prior art, one of the objectives of the present invention is to provide a composition containing ergothioneine and a silicon elastomer active material.

[0006] A second objective of this invention is to provide the application of compositions containing ergothioneine and silicon elastomer actives.

[0007] One of the objectives of this invention is achieved through the following technical solution:

[0008] A composition containing ergothioneine and a silicon elastomer active ingredient, comprising 0.001-10% ergothioneine and 0.05-20% silicon elastomer active ingredient; said silicon elastomer active ingredient comprises polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer and / or polydimethylsiloxane cross-linked polymer.

[0009] In this invention, polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer and polydimethylsiloxane crosslinked polymer serve as active ingredients in the silicon elastomer, stabilizing ergothioneine. By adjusting the ratio of the active ingredient in the silicon elastomer to ergothioneine, this invention can reduce the trimethylamine odor produced by ergothioneine under conditions such as high temperature, light exposure, and room temperature, thus enabling wider applications of ergothioneine.

[0010] The silicone elastomer involved in this invention (including at least one of polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer and polydimethylsiloxane crosslinked polymer) is an excellent skin feel modifier, with a light skin feel, good spreadability, good pore coverage and soft focus effect, and can be used in skin care, makeup, sun protection and hair care products.

[0011] In a preferred embodiment of the present invention, the composition containing ergothioneine and the active material of the silicon projectile comprises, by weight percentage, 5-40% of the active material in the silicon projectile. For example, when the active material in the silicon projectile is a polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer, the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer comprises 5-40% of the silicon projectile. Similarly, when the active material in the silicon projectile is a polydimethylsiloxane crosslinked polymer, the polydimethylsiloxane crosslinked polymer comprises 5-40% of the silicon projectile.

[0012] As a preferred embodiment of the present invention, the composition containing ergothioneine and a silicon elastomer active material comprises 0.01-0.5% ergothioneine and 0.1-15% silicon elastomer active material; the silicon elastomer active material comprises a polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, or a polydimethylsiloxane cross-linked polymer.

[0013] As a preferred embodiment of the present invention, the composition containing ergothioneine and a silicon elastomer active material comprises 0.05-0.15% ergothioneine and 0.4-10% silicon elastomer active material; the silicon elastomer active material comprises a polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, or a polydimethylsiloxane cross-linked polymer.

[0014] As a preferred embodiment of the present invention, in the composition containing ergothioneine and the silicone elastomer, the weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothioneine is (320-1):1, preferably (50-3):1, more preferably (25-3):1, even more preferably (20-10):1, and even more preferably 10:1. When the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer and the ergothioneine are in the above-mentioned specific ratio, the composition using this specific ratio was placed at heat resistance (48°C), cold resistance (-15°C), and room temperature for 3 months without the detection of trimethylamine odor.

[0015] As a preferred embodiment of the present invention, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothioneine is (320-1):1, preferably (50-3):1, further preferably (25-3):1, even further preferably (20-10):1, and even more preferably 10:1; when the polydimethylsiloxane crosslinked polymer and the ergothioneine are in the above-mentioned specific ratio, the composition using the specific ratio is placed at heat resistance (48°C), cold resistance (-15°C), and room temperature for 3 months, and no trimethylamine odor is found.

[0016] As a preferred embodiment of the present invention, the composition containing ergothioneine and a silicone elastomer comprises 0.001-10% ergothioneine, 0.05-20% silicone elastomer, 0.1-10% emulsifier, 1-30% oil, and the balance being solvent; the silicone elastomer comprises polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer and / or polydimethylsiloxane cross-linked polymer.

[0017] In a preferred embodiment of the present invention, the solvent is water.

[0018] As a preferred embodiment of the present invention, the composition containing ergothioneine and a silicone elastomer comprises 0.01-0.5% ergothioneine, 0.1-15% silicone elastomer, 0.3-5% emulsifier, 5-20% oil, and the balance being solvent; the silicone elastomer comprises a polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, or a polydimethylsiloxane cross-linked polymer.

[0019] As a preferred embodiment of the present invention, the composition containing ergothioneine and a silicone elastomer comprises 0.05-0.15% ergothioneine, 0.4-10% silicone elastomer, 0.3-4.5% emulsifier, 5-16% oil, and the balance being solvent; the silicone elastomer comprises a polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, or a polydimethylsiloxane cross-linked polymer.

[0020] As a preferred embodiment of the present invention, the composition containing ergothioneine and silica elastomer active ingredients further includes at least one of the following: active ingredient, skin conditioning agent, thickener, moisturizer, preservative, antioxidant, solubilizer, humectant, chelating agent, colorant, pH adjuster, and fragrance.

[0021] As a preferred embodiment of the present invention, the active ingredients include at least one of anti-aging active substances, anti-acne active substances, moisturizing active substances, antioxidant active substances, anti-glycation active substances, and anti-allergy active substances.

[0022] As a preferred embodiment of the present invention, the composition is a skin care product or cosmetic, including at least one of toner, serum, lotion, gel, cream, ointment, mask and freeze-dried powder.

[0023] The second objective of this invention is achieved by the following technical solution:

[0024] The present invention also provides the use of the composition containing ergothioneine and silica elastomer active ingredients in the preparation of cosmetics or skin care products.

[0025] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0026] (1) The composition containing ergothioneine and silicone elastomer provided by the present invention uses a specific ratio of ergothioneine and silicone elastomer to reduce the trimethylamine odor produced by ergothioneine under conditions such as high temperature, light exposure and room temperature, thus making ergothioneine more widely used in cosmetics. When this composition containing ergothioneine and silicone elastomer is applied to cosmetics, it can play a good role in skin feel adjustment. Detailed Implementation

[0027] The present invention will now be further described in conjunction with specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments. Unless otherwise specified, the raw materials, equipment, etc., used in the following embodiments can all be obtained through commercial channels.

[0028] To address the problem of ergothioneine's instability and the resulting trimethylamine odor during application, this invention employs a specific ratio of silicon elastomer active material to stabilize ergothioneine, thereby reducing the generation of trimethylamine odor, expanding the application of ergothioneine, and providing consumers with a better experience.

[0029] Examples 1-5

[0030] A composition containing ergothioneine and a silicone elastomer active ingredient, comprising ergothioneine, a silicone elastomer, an emulsifier, an oil, a preservative, and a solvent; the silicone elastomer includes a polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer and / or a polydimethylsiloxane cross-linked polymer. See Table 1 below for details.

[0031] Table 1 Formulation table for Examples 1-5

[0032]

[0033] The compositions containing ergothioneine and silicon elastomer active ingredients in Examples 1-5 were prepared according to the following method:

[0034] Mix the emulsifier, oil, and silicone elastomer according to the formula, heat to 80°C, stir evenly, cool to room temperature (about 25°C), then add ergothioneine, preservative, and water, stir evenly, and it is ready.

[0035] Comparative Example 1

[0036] The difference between Comparative Example 1 and Example 1 is that the amount of silicon elastomer was adjusted to 0.04%, and the missing amount was made up with water to 100%, while the rest was the same as Example 1.

[0037] Comparative Example 2

[0038] The difference between Comparative Example 2 and Example 2 is that the amount of ergothioneine was adjusted to 12% and the amount of water was 28%, while the rest was the same as in Example 1.

[0039] Evaluation of the effects of samples from Examples 1-5 and Comparative Example-2

[0040] Samples from Examples 1-5 and Comparative Examples 1-2 were placed under light, heat (48℃), cold (-15℃), and room temperature conditions for 3 months respectively, and their odor was evaluated. Specifically, five odor evaluators (who had received professional training in odor-related fields) were selected. Each evaluator applied 3g of sample to the back of their hand, spread it in circular motions, and smelled for an amine odor during the spreading and complete absorption process, then scored the evaluator. Odor levels were defined as follows: 1. No amine odor; 2. Slight amine odor, acceptable; 3. Amine odor, acceptable; 4. Obvious amine odor, unacceptable; 5. Amine odor too strong, intolerable. Result determination: The average score of the five evaluators was taken. A score less than 2 points indicated no amine odor, while a score greater than 2 points indicated an amine odor. Specific results are shown in Table 2 below.

[0041] Table 2 Evaluation Results Record of Examples 1-5 and Comparative Examples 1-2

[0042] plan illumination Heat resistant (48℃) Cold-resistant (-15℃) normal temperature Example 1 1.7 1 1 1 Example 2 1.5 1 1 1 Example 3 1.3 1 1 1 Example 4 1.2 1 1 1 Example 5 1.8 1 1 1 Comparative Example 1 3.6 2.5 1 1 Comparative Example 2 4.5 3.8 1 2.1

[0043] As can be seen from the records in Table 2, the samples of Examples 1-5 all showed good stability of ergothioneine under light, heat, cold and room temperature conditions, and no amine odor was produced.

[0044] The sample in Comparative Example 1 produced an amine odor under light and heat conditions; the sample in Comparative Example 2 produced an amine odor under light, heat, and room temperature conditions.

[0045] It is evident that the composition provided in the embodiments of the present invention, with ergothioneine and silicon elastomer set within a reasonable dosage range, can enhance the stability of ergothioneine.

[0046] Examples 6-8

[0047] This lightweight face cream is made from ergothioneine, silicone elastomers, emulsifiers, oils, thickeners, moisturizers, polyols, preservatives, and water. See Table 3 below for details.

[0048] Table 3 Formulation table for Examples 6-8

[0049]

[0050]

[0051] The face creams in Examples 6-8 were prepared according to the following method:

[0052] (1) Take a 100mL beaker A and first add the amount of MONTAN OV in the formula. TM 202 emulsifier, SIMULSOL TM 165. Mix coconut oil alcohol-caprylate / capric acid ester, cyclopentamethoxysiloxane, DM5, caprylic / capric triglyceride, and BSG5045 by heating to 80°C.

[0053] (2) Take another 100mL beaker B and add the prescribed amounts of 1,3-butanediol (humectant) and SEPIMAX. TM Mix ZEN and water (reserve 10g), heat to 80℃, then add the mixture to beaker A and homogenize at 5000 rpm for 3 minutes. Then add the required amount of SEPIPLUS. TM After homogenizing with thickener S for 3 minutes and cooling to 40°C, add the formulated amounts of AQUAXYL humectant and 1,3-butanediol (a preservative solvent) and effisin. TM hdamultifunctional,effisin TM hdmultifunctional;

[0054] (3) Take another 100mL beaker C, add the amount of ergothioneine in the formula and the remaining 10g of water, mix and dissolve, then add it to beaker A and stir at 700rpm for 5 minutes.

[0055] Samples obtained in Examples 6-8 were placed under light, heat (48℃), cold (-15℃), and room temperature for 3 months respectively, and their odor was evaluated. Specifically, 5 odor evaluators (who had received professional training in odor-related fields) were selected. Each evaluator applied 3g of sample to the back of their hand, spread it in circular motions, and smelled for an amine odor during the spreading and complete absorption process, then scored the evaluator. Odor levels were defined as follows: 1. No amine odor; 2. Slight amine odor, acceptable; 3. Amine odor, acceptable; 4. Obvious amine odor, unacceptable; 5. Amine odor too strong, intolerable. Result determination: The average score of the 5 evaluators was taken. A score less than 2 points indicated no amine odor, while a score greater than 2 points indicated an amine odor. The results are shown in Table 4 below.

[0056] Table 4. Results of face cream testing in Examples 6-8

[0057] plan illumination Heat resistant (48℃) Cold-resistant (-15℃) normal temperature Example 6 5 3 1 2 Example 7 1.6 1 1 1 Example 8 1.2 1 1 1

[0058] As can be seen, the face creams of Examples 7-8, which use a suitable ratio of silicone elastomer and ergothioneine, do not produce an amine odor under different conditions. However, Example 6, which omits the silicone elastomer, produces an amine odor under light, heat, and room temperature.

[0059] Examples 9-11

[0060] This eye serum cream is made from ergothioneine, silicone elastomers, emulsifiers, oils, thickeners, skin feel modifiers, pH adjusters, moisturizers, colorants, active ingredients, preservatives, and water. See Table 5 below for details.

[0061] Table 5 Formulation table for Examples 9-11

[0062]

[0063]

[0064]

[0065] The eye serums in Examples 9-11 were prepared according to the following method:

[0066] (1) Take a 100mL beaker A and add the formula amounts of STRUCTUREXL and SEPIMAX. TM ZEN Disperse Ultrez21 and water (leaving 10g remaining) evenly.

[0067] (2) Take 100mL beaker B and add the prescribed amounts of ABILCARE85 and FLUIDIFEEL. TM EASY, MIRASILD-DMLLVA2, DM5, BSG-200, PURESILORG01, are evenly dispersed.

[0068] (3) Pour the material in beaker A into beaker B, and then add the prescribed amounts of triethanolamine, LUBRAJELCG, and HYDROXYPROLISILANE. Add gardenia fruit extract and homogenize for 3 minutes, then add the prescribed amount. HDA-AP, K900 and glycerin.

[0069] (4) Finally, add the amount of ergothioneine and the remaining 10g of water to 50mL beaker C, dissolve them well, then add beaker B and stir well.

[0070] Samples obtained in Examples 9-11 were placed under light, heat (48℃), cold (-15℃), and room temperature for 3 months respectively, and their odor was evaluated. Specifically, 5 odor evaluators (who had received professional training in odor-related fields) were selected. Each evaluator applied 3g of sample to the back of their hand, spread it in circular motions, and smelled for an amine odor during the spreading and complete absorption process, then scored the evaluator. Odor levels were defined as follows: 1. No amine odor; 2. Slight amine odor, acceptable; 3. Amine odor, acceptable; 4. Obvious amine odor, unacceptable; 5. Amine odor too strong, intolerable. Result determination: The average score of the 5 evaluators was taken. A score less than 2 points indicated no amine odor, while a score greater than 2 points indicated an amine odor. The results are shown in Table 6 below.

[0071] Table 6. Record of Measurement Results of Eye Serums in Examples 9-11

[0072] plan illumination Heat resistant (48℃) Cold-resistant (-15℃) normal temperature Example 9 4 4 1 2 Example 10 1.4 1 1 1 Example 11 1.2 1 1 1

[0073] As can be seen, the eye serums in Examples 10-11, using a suitable ratio of silicone elastomer and ergothioneine, do not produce an amine odor under different conditions. However, Example 9, which omits the silicone elastomer, produces an amine odor under light, heat, and room temperature.

[0074] Examples 12-14

[0075] This serum is made from ergothioneine, silicone elastomers, emulsifiers, oils, moisturizers, thickeners, active ingredients, preservatives, colorants, fragrances, and water. See Table 7 below for details.

[0076] Table 7 Formulation table for Examples 12-14

[0077]

[0078]

[0079]

[0080] The serums in Examples 12-14 were prepared according to the following method:

[0081] (1) Take 100mL beaker A and add the amount of MONTAN OV specified in the formula. TM L, SIMULSOL TM 165. LIPOWAX TM D. Hydrogenated polydecene, C13-16 isoparaffin, tridecyl trimellitate, BUTYROSPERMUMPARKII fruit oil and hydrogenated polyisobutylene are dissolved in a water bath and dispersed evenly. Then, the prescribed amounts of DM5, DM350A2, DM60000, SELACV-540 and SELADV-641 are added and stirred evenly.

[0082] (2) Take 100mL beaker B, add the formula amount of glycerol, butylene glycol, xanthan gum and water, and heat in a water bath to 85℃.

[0083] (3) Pour the material in beaker B into beaker A, and then add the amount of SIMULGEL specified in the formula. TM 600, then homogenize for 3 minutes, then cool to below 40°C, and add the prescribed amount of euxyl. TM Mix k350 preservative, gardenia fruit extract ZM-GRDE20-HSP (gardenia red), gardenia fruit extract ZM-GYWE70-HSP (gardenia yellow), ergothioneine, and flavoring until well combined.

[0084] The serum samples obtained in Examples 12-14 were placed under light, heat (48℃), cold (-15℃), and room temperature for 3 months respectively, and their odor was evaluated. Specifically, 5 odor evaluators (who had received professional training in odor-related fields) were selected. Each evaluator applied 3g of sample to the back of their hand, spread it in circular motions, and smelled for an amine odor during the spreading and complete absorption process, then scored the evaluator. Odor levels were defined as follows: 1. No amine odor; 2. Slight amine odor, acceptable; 3. Amine odor, acceptable; 4. Noticeable amine odor, unacceptable; 5. Amine odor too strong, intolerable. Result determination: The average score of the 5 evaluators was taken. A score less than 2 points indicated no amine odor, while a score greater than 2 points indicated an amine odor. The results are shown in Table 8 below.

[0085] Table 8 Record of Measurement Results of Essence Emulsions in Examples 12-14

[0086] plan illumination Heat resistant (48℃) Cold-resistant (-15℃) normal temperature Example 12 4.2 3.6 1 2 Example 13 1.6 1.4 1 1 Example 14 1.2 1 1 1

[0087] As can be seen, the serums in Examples 12-14, using a suitable ratio of silicone elastomer and ergothioneine, did not produce an amine odor under different conditions. However, Example 12, which omitted the silicone elastomer, produced an amine odor under light, heat, and room temperature.

[0088] The above embodiments are merely preferred embodiments of the present invention and should not be construed as limiting the scope of protection of the present invention. Any non-substantial changes and substitutions made by those skilled in the art based on the present invention shall fall within the scope of protection claimed by the present invention.

Claims

1. A composition containing ergothioneine and a silicon elastomer active ingredient, characterized in that, It includes 0.05-0.15% ergothioneine and 0.4-10% silicon elastomer active material; the silicon elastomer active material is a combination of polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer and cyclopentasiloxane, or the silicon elastomer active material is a combination of polydimethylsiloxane cross-linked polymer and cyclopentasiloxane; or the silicon elastomer active material is a combination of polydimethylsiloxane / vinyl polydimethylsiloxane cross-linked polymer, polydimethylsiloxane and C13-15 alkyl.

2. The composition containing ergothioneine and silicon elastomer active material as described in claim 1, characterized in that, The weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothioneine is (320-1):1; Alternatively, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothionein is (320-1):

1.

3. The composition containing ergothioneine and a silicon elastomer active ingredient as described in claim 1, characterized in that, The weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothioneine is (50-3):1; Alternatively, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothionein is (50-3):

1.

4. The composition containing ergothioneine and a silicon elastomer as described in claim 1, characterized in that, The weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothioneine is (25-3):1; Alternatively, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothionein is (25-3):

1.

5. The composition containing ergothioneine and a silicon elastomer as described in claim 1, characterized in that, The weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothioneine is (20-10):1; Alternatively, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothionein is (20-10):

1.

6. The composition containing ergothioneine and a silicon elastomer as described in claim 1, characterized in that, The weight ratio of the polydimethylsiloxane / vinyl polydimethylsiloxane crosslinked polymer to the ergothionein is 10:1; Alternatively, the weight ratio of the polydimethylsiloxane crosslinked polymer to the ergothionein is 10:

1.

7. A cosmetic comprising the composition of any one of claims 1-6 containing ergothioneine and a silicone elastomer active ingredient, characterized in that, The cosmetic product contains 0.05-0.15% ergothioneine, 0.4-10% silicone elastomer active ingredient, 0.1-10% emulsifier, 1-30% oil, and the remainder solvent.

8. The cosmetic product as described in claim 7, characterized in that, It includes 0.05-0.15% ergothioneine, 0.4-10% silicon elastomer active material, 0.3-5% emulsifier, 5-20% oil, and the remainder solvent.

9. The cosmetic product as described in claim 7, characterized in that, The composition further includes at least one of the following: skin conditioning agent, thickener, moisturizer, preservative, antioxidant, solubilizer, chelating agent, colorant, pH adjuster, and fragrance.

10. The cosmetic product as described in claim 7, characterized in that, The cosmetics include at least one of the following: toner, serum, lotion, gel, cream, ointment, mask, and freeze-dried powder.

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