Compounds based on quinazoline substituted glutarimide scaffold and uses thereof

Abstract

The present disclosure relates to compounds of Formula (I) or salts, enantiomers, stereoisomers, solvates, polymorphs thereof, and uses thereof. The present disclosure also relates to pharmaceutical compositions comprising a compound of Formula (I) or salts, enantiomers, stereoisomers, solvates, polymorphs thereof as an active ingredient, and uses thereof. The present disclosure is designed to synthesize a series of compounds that are effective in preventing and / or treating diseases or disorders associated with cereblon protein.

Description

Technical Field

[0001] This disclosure relates to compounds of formula (I) or salts thereof, enantiomers, diastereomers, isotope-enriched analogs, solvates, prodrugs or polymorphs and their uses, in particular their use in the prevention and / or treatment of diseases or conditions associated with cereblon protein (CRBN).

[0002] Background Technology

[0003] Thalidomide, lenalidomide, and other phthalimide immunomodulatory drugs (IMiDs) have shown significant efficacy in treating multiple myeloma and autoimmune diseases. However, it wasn't until 2010 that their direct binding protein was identified as the E3 ubiquitin ligase cereblon (CRBN). Subsequent studies confirmed that these drugs work by inducing the interaction between transcription factors IKZF1 / 3 and CRBN proteins, leading to their ubiquitination and degradation. Compared to traditional small-molecule inhibitors, these molecular glue protein-degrading drugs have a natural mechanistic advantage: the latter work by occupying the functional domains of target proteins for extended periods, while these drugs directly degrade and eliminate the entire target protein, often achieving far greater efficacy than traditional small-molecule inhibitors. They can target "undruggable" targets and have lower requirements for binding strength, catalytic dosage, and concentration, overcoming the clinical resistance problems associated with traditional small molecules. Furthermore, molecular glue degraders typically have small molecular weights and good drug-like properties, making their development highly valued. Based on the CRBN E3 ubiquitin ligase and molecular glue degradation mechanism, a series of compounds have been developed, such as the marketed pomalidomide and Bristol-Myers Squibb's (BMS) CC-122, CC-220, CC-90009, CC-99282, and CC-92480, which are currently undergoing clinical trials; Novartis' DKY709; and C4 Therapeutics' CFT7455. The degradation substrates of these molecular glues have also expanded from the initially discovered transcription factors IKZF1 / 3 to casein kinase 1α (CK1α), zinc finger protein 91 (ZFP91), and translation factor GSPT1, etc. The degradation of these protein substrates allows molecular glues to exert immunomodulatory, anti-inflammatory, and anti-tumor pharmacological activities. Currently, the number of molecular glue candidate compounds discovered is very limited, and theoretically, there are many diverse pathogenic proteins that can be used as degradation substrates for molecular glue development. Therefore, it is necessary to rationally and diversely design and develop more molecular glues to degrade and knock out more pathogenic proteins and apply them to the treatment of diseases related to these pathogenic proteins.

[0004] The compounds listed above all contain the benzoglutarimide skeleton common to thalidomide-based IMiDs. Bristol-Myers Squibb's (BMS) novel molecular adhesive, Avadomide (CC-122), has a significantly different structural skeleton and exhibits remarkable efficacy. Avadomide can significantly degrade IKZF1 and 3 by binding to CRBN, thereby downregulating cytokines such as TNF-α, demonstrating antitumor and immunomodulatory activities. Avadomide is currently in Phase II clinical trials, testing its therapeutic effects on various related tumors (NCT02406742, NCT02859324, NCT03834623). This invention is based on Avadomide's quinazoline-substituted glutarimide skeleton, aiming to develop more novel, highly efficient, low-toxicity, stable, and low-cost molecular adhesive degraders to meet clinical application needs through rational design. Summary of the Invention

[0005] In view of the above, the purpose of this disclosure is to provide novel molecular colloidal protein degradation drugs, their uses, and their methods of use.

[0006] To achieve the above and other related objectives, in one aspect, this disclosure provides a compound of formula (I) or a salt thereof, stereoisomers (including enantiomers and diastereomers), isotope-enriched analogs, solvates, prodrugs, or polymorphs:

[0007]

[0008] in

[0009] R c1 Indicates H or C 1-3 Alkyl, R c2 R c3 R c4 R c5 and R c6 The same or different and each independently represents H, D or C. 1-3 alkyl;

[0010] (R 1a ) n The quinazoline ring in expression (I) can optionally be divided by n R 1a Replace, where R 1a Let n represent halogen, and n represent integers 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 ...

[0011] 1, 2, or 3; and

[0012] R a The following expression is represented:

[0013] R a1 -X2-L1-X1-,

[0014] in,

[0015] X1 represents an optional substituted cycloalkylene group, an optional substituted heterocyclic group, an optional substituted aryl group, or an optional substituted heteroaryl group;

[0016] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene, or with one or more R groups inserted into its main carbon chain. d1 and / or one or more groups R d2 and / or one or more groups R d1 With R d2 Any combination of optionally substituted straight or branched C 2-60 alkylene, wherein the group R d1 R d2 Or group R d1 With R d2 Any combination of these elements will break one or more pairs of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R d1 Independently selected from O, S, N(R) d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O),

[0017] NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R d3 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. d1 At that time, each group R d1 They are not directly connected to each other; each group R d2 Independently selected from optional substituted cycloalkylene, optional substituted heterocyclic, optional substituted aryl, optional substituted heteroaryl, alkenyl, ynylene, or any combination thereof;

[0018] X2 represents the key; and

[0019] R a1 Indicates NR d4 R d5 C(O)NR d6 R d7 ,NHC(O)R d8 ,NHC(O)NR d9 R d10 C(O)OR d11 OC(O)R d12 OR d13 SR d14 C(O)Rd15 C(S)R d16 S(O)R d17 S(O)2R d18 S(O)2NHR d19 NHS(O)2R d20 S(O)2OR d21 OS(O)2R d22 Optional replacement of straight or branched C 1-10 Alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclic, optionally substituted aryl, or optionally substituted heteroaryl, wherein R d4 R d5 R d6 R d7 R d9 R d10 R d11 R d13 R d14 R d19 and R d21 Each independently represents H, and optionally substituted straight or branched C. 1-10 Alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocyclic or optionally substituted heteroaryl, and R d8 R d12 R d15 R d16 R d17 R d18 R d20 and R d22 Indicates the alternative substitution of straight or branched chains C 1-10 Alkyl, optionally substituted cycloalkyl, optionally substituted heterocyclic, optionally substituted aryl or optionally substituted heteroaryl;

[0020] or

[0021] X1 represents N(R) e1 ), O, S, alynyl, alkenyl, optionally substituted cycloalkyl, optionally substituted heterocyclic, optionally substituted aryl, or optionally substituted heteroaryl, wherein R e1 Indicates H or C 1-3 Alkyl, or X1 indicates a bond;

[0022] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene, or with one or more R groups inserted into its main carbon chain. e2 and / or one or more groups R e3 and / or one or more groups R e2 With R e3 Any combination of optionally substituted straight or branched C 2-60alkylene, wherein the group R e2 R e3 Or group R e2 With R e3 Any combination of these elements will break one or more pairs of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R e2 Independently selected from O, S, N(R) e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, where R e4 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. e2 At that time, each group R e2 They are not directly connected to each other; each group R e3 Independently selected from optional substituted cycloalkylene, optional substituted heterocyclic, optional substituted aryl, optional substituted heteroaryl, alkenyl, ynylene, or any combination thereof;

[0023] X2 represents C(O), S(O) or S(O)2, or X2 represents a bond;

[0024] R a1 The following expression is represented:

[0025]

[0026] Where R f1 express:

[0027] -NCH2CH2N-;

[0028] Where the symbol * represents the connection point with group X2, R g1 Indicates H or C 1-3 Alkyl, ring A represents a cycloalkyl or heterocyclic group, (R g2 ) n1 This indicates that ring A can be optionally divided by n1 groups R g2 Replace, n1 represents an integer from 0 to 8, and each R g2 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0029] Where the symbol ** represents the connection point with group X2, R g3 Indicates H or C 1-3 Alkyl, cyclic B indicates cycloalkyl or heterocyclic group, (R g4 ) n2 This indicates that ring B is optionally divided by n2 groups R g4 Replace, n2 represents integers from 0 to 8, and each R g4 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; or

[0030] Wherein the ring C represents a cycloalkyl or heterocyclic group, (R g5 ) n3 This indicates that the ring C is optionally surrounded by n3 groups R. g5 Replacement, n3 represents integers from 0 to 8, each R g5 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0031] R f2 Indicates H, halogen, C 1-3 Alkyl or halogenated C 1-3 alkyl;

[0032] R f3 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Where ring D represents a cycloalkylene, heterocyclic, arylene, or heteroarylene group, (R g6 ) n4 This indicates that ring D is optionally surrounded by n4 groups R g6 Replacement, n4 represents integers from 0 to 8, each R g6 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0033] R f4 express The symbol *** represents the group R. f5 The connection point, ring E represents cycloalkylene, heterocyclic, arylene, or heteroarylene.

[0034] (R g7 ) n5 This indicates that ring E is optionally surrounded by n5 groups R g7 Replacement, n5 represents integers from 0 to 8, each R g7 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; and

[0035] R f5 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl,

[0036] Where ring F represents cycloalkyl, heterocyclic, aryl, or heteroaryl, (R g8 ) n6 This indicates that ring F is optionally surrounded by n6 groups R g8 Replacement, n6 represents an integer from 0 to 8, each R g8 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0037] or

[0038] X1 represents N(R1), O, S, alkyne, or alkenyl, where R1 represents H or C. 1-3 Alkyl, or X1 indicates a bond;

[0039] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene;

[0040] X2 represents N(R2), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted 4- to 8-membered heterocyclic groups containing 1 to 2 nitrogen atoms, triazolyl, triazolyl-NH-, -NH-triazolyl, or optionally substituted phenylene, wherein R2 represents H or C. 1-3 Alkyl, or X2, indicates a bond; and

[0041] R a1 The terms represent hydroxyl, optional substituted adamantyl, optional substituted nordamantyl, optional substituted cuboalkyl, optional substituted spirocyclic, optional substituted bicyclic [2.2.2]octane-1-yl, optional substituted bicyclic

[0042] [2.2.2]octane-2-yl, optionally substituted borneol, optionally substituted bicyclo[2.2.1]heptyl, optionally substituted bicyclo[2.2.1]heptenyl, optionally substituted p-menthylyl or optionally substituted m-menthylyl, wherein when R a1 When representing a hydroxyl group, X2 represents a bond;

[0043] or

[0044] X1 represents N(R3), O, or S, where R3 represents H or C. 1-3 alkyl;

[0045] L1 represents either the linear or branched chain C, which can be substituted. 4-60 Alkylene;

[0046] X2 represents N(R4), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, where R4 represents H or C. 1-3 Alkyl, or X2, indicates a bond; and

[0047] R a1 Indicates a heterocyclic group with optional substitution;

[0048] or

[0049] X1 represents an alkyne or alkenyl group, or X1 represents a bond;

[0050] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene; and

[0051] X2 represents N(R5), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, where R5 represents H or C. 1-3 Alkyl, or X2, indicates a bond; and

[0052] R a1 Indicates a heterocyclic group with optional substitution;

[0053] or

[0054] X1 represents N(R6), O, S, alkyne, or alkenyl, where R6 represents H or C. 1-3 Alkyl, or X1 indicates a bond;

[0055] L1 indicates a linear or branched C-chain whose main carbon chain contains one or more groups R7 and / or one or more groups R8 and / or any combination of groups R7 and R8, which may be optionally substituted. 2-60 Alkylene, wherein the groups R7, R8, or any combination of R7 and R8 break one or more pairs of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R7 is independently selected from O, S, N (R9), C (O), C (O)O,

[0056] OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O,

[0057] OS(O)2, S(O)2NH or NHS(O)2, where R9 represents H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 When two or more groups R7 are inserted into the main carbon chain of an alkylene group, the groups R7 are not directly connected to each other; each group R8 is independently selected from cycloalkylene, heterocyclic, triazolyl, alkenyl, ynylene, or any combination thereof, wherein the cycloalkylene, heterocyclic, and triazolyl groups are optionally further selected from D, and optionally deuterated C. 1-4 Alkyl, optionally deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 alkyl,

[0058] NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0059] X2 represents N(R) 10 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O),

[0060] S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optionally substituted four- to eight-membered heterocyclic groups containing one to two nitrogen atoms, triazolyl, triazolyl-NH-, -NH-triazolyl, or optionally substituted phenylene, wherein R 10 Indicates H or C 1-3 Alkyl, or X2, indicates a bond; and

[0061] R a1 Represents a hydroxyl group, an optional substituted heterocyclic group, or an optional substituted cycloalkyl group, wherein when R a1 When representing a hydroxyl group, X2 represents a bond;

[0062] or

[0063] R a The following expression is represented:

[0064] R a2 -X3-,

[0065] in,

[0066] X3 represents N(R) 11 ), C(O)O, OC(O), C(O)NH, NHC(O), O, S, optionally substituted cycloalkylene, optionally substituted arylene, optionally substituted heteroarylene or optionally substituted heterocyclic group, wherein R 11 Indicates H or C 1-3 Alkyl groups, and

[0067] R a2 Indicates an optional substituted cycloalkyl, an optional substituted heterocyclic, an optional substituted heteroaryl, or an optional substituted aryl;

[0068] as well as

[0069] R b This indicates C that is optionally substituted with D or halogen. 1-60 alkyl, or

[0070] R b The following expression is represented:

[0071] R b1 -X4-L2-,

[0072] in,

[0073] L2 represents the C of the optionally substituted straight or branched chain.2-60 Alkylene, or with one or more R groups inserted into its main carbon chain. 12 and / or one or more groups R 13 and / or one or more groups R 12 With R 13 Any combination of optionally substituted straight or branched C 2-60 alkylene, wherein the group R 12 R 13 Or group R 12 With R 13 Any combination of these elements will break the carbon-carbon bonds between one or more pairs of adjacent carbon atoms in the main carbon chain.

[0074] Each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH,

[0075] NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 14 Independently represent H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 12 At that time, each group R 12 They are not directly connected to each other; each group R 13 The group is independently selected from cycloalkyl, heterocyclic, aryl, heteroaryl, alkenyl, ynylene, or any combination thereof, wherein the cycloalkyl, heterocyclic, aryl, and heteroaryl groups are optionally further selected from D, or optionally deuterated C. 1-4 Alkyl, optionally deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 alkyl,

[0076] NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0077] X4 represents N(R) 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O),

[0078] S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optional substituted cycloalkylene, optional substituted arylene, optional substituted heterocyclic, optional substituted heteroaryl, triazolyl-NH-, or -

[0079] NH-triazolyl, where R 15 Indicates H or C 1-3 Alkyl, or X4, indicates a bond; and

[0080] R b1 Indicates an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclic, or an optionally substituted heteroaryl;

[0081] or

[0082] R a Indicates halogen or cyano, and

[0083] R b The following expression is represented:

[0084] R b2 -X5-L3-,

[0085] Where L3 represents the C of the optionally substituted straight or branched chain. 2-60 Alkyl groups, or optionally one or more R groups inserted into their main carbon chain. 16 and / or one or more groups R 17 and / or one or more groups R 16 With R 17 Any combination of optionally substituted straight or branched C 2-60 alkylene, the group R 16 R 17 Or group R 16 With R 17 Any combination of these elements will break one or more pairs of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R 16 Independently selected from O, S, N(R) 18 ), C(O), C(O)O, OC(O), C(O)NH,

[0086] NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 18 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 16 At that time, each group R 16 They are not directly connected to each other; each group R 17The group is independently selected from cycloalkyl, heterocyclic, aryl, heteroaryl, alkenyl, ynylene, or any combination thereof, wherein the cycloalkyl, heterocyclic, aryl, and heteroaryl groups are optionally further selected from D, or optionally deuterated C. 1-4 Alkyl, optionally deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 alkyl,

[0087] NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0088] X5 represents N(R) 19 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O),

[0089] S(O)2, S(O)2NH, NHS(O)2, S(O)2O, or OS(O)2, where R 19 Indicates H or C 1-3 Alkyl, or X5, indicates a bond; and

[0090] R b2 The expression represents an optionally substituted cycloalkyl, an optionally substituted aryl, an optionally substituted heterocyclic, or an optionally substituted heteroaryl, or represents the following formula:

[0091]

[0092] Where R f1 R f2 R f3 R f4 and R f5 As defined above.

[0093] In another aspect, this disclosure provides a pharmaceutical composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof, a stereoisomer (including enantiomers and diastereomers), a solvate, an isotope-enriched analog, a prodrug or polymorph, and at least one pharmaceutically acceptable carrier.

[0094] In another aspect, this disclosure also provides a kit or reagent kit comprising: a compound of formula (I) or a pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising therethe.

[0095] On the other hand, this disclosure provides compounds of formula (I), or pharmaceutically acceptable salts, enantiomers, diastereomers, solvates, prodrugs, or polymorphs thereof, for use as pharmaceuticals.

[0096] On the other hand, this disclosure provides a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer (including enantiomers and diastereomers), solvate, isotope-enriched analog, prodrug or polymorph, or a pharmaceutical composition thereof, for the treatment or prevention of diseases or conditions associated with cereblon protein.

[0097] In another aspect, this disclosure also provides the use of the compound of formula (I) or a pharmaceutically acceptable salt thereof, stereoisomers (including enantiomers and diastereomers), solvates, isotope-enriched analogs, prodrugs or polymorphs thereof, or pharmaceutical compositions thereof, for the preparation of a medicament for the treatment or prevention of diseases or conditions associated with cereblon protein.

[0098] In another aspect, this disclosure also provides a method for treating or preventing diseases or conditions associated with cereblon protein, comprising administering to a subject a therapeutically effective amount of a compound of formula (I), or a pharmaceutically acceptable salt, stereoisomer (including enantiomers and diastereomers), solvate, isotope-enriched analog, prodrug, or polymorph thereof, or the pharmaceutical composition thereof. Invention Details

[0099] The following detailed description is provided as exemplary embodiments to assist those skilled in the art in understanding and implementing the present disclosure. However, it should be understood that such description is not intended to limit the scope of the disclosure, and various modifications and variations may be made to the specific embodiments described herein without departing from the spirit and scope of the disclosure, all of which fall within the claimed scope of the disclosure.

[0100] I. Compounds

[0101] Compound of formula (I)

[0102] This disclosure provides a compound of formula (I) or a salt thereof (including pharmaceutically acceptable salts), a stereoisomer (including enantiomers and diastereomers), a solvate, an isotope-enriched analog, a prodrug, or a polymorph:

[0103]

[0104] Where R c1 R c2 R c3 R c4 Rc5 R c6 R b 、(R 1a ) n R a R 1a And n is as defined in the compound of formula (I) above and in its various embodiments.

[0105] In some embodiments of this disclosure, R c1 Indicates H or C 1-3 Alkyl (e.g., methyl, ethyl, or propyl).

[0106] In some embodiments of this disclosure, R c1 H represents H.

[0107] In some embodiments of this disclosure, R c2 R c3 R c4 R c5 and R c6 The same or different and each independently represents H, D or C. 1-3 Alkyl (e.g., methyl, ethyl, or propyl). In some sub-implementations of this disclosure, R c2 R c3 R c4 R c5 and R c6 H can be represented as either the same or different and as each independent entity.

[0108] In some embodiments of this disclosure, (R 1a ) n The quinazoline ring in expression (I) can optionally be divided by n R 1a Replace, where R 1a The symbol represents a halogen (e.g., fluorine, chlorine, bromine, or iodine), and n represents an integer 0, 1, 2, or 3. In some sub-implementations of this disclosure, n represents the integer 0.

[0109] In some embodiments of this disclosure, the compound of formula (I) is also the compound of formula (I-1):

[0110]

[0111] Where R c1 R c2 R c3 R c4 R c5 R c6 R b 、(R 1a ) n R a R 1aand n are as defined in the compounds of formula (I) above and in their respective embodiments;

[0112] Where R a The following expression is represented:

[0113] R a1 -X2-L1-X1-,

[0114] Where X1 represents an optional substituted cycloalkyl group (e.g., an optional substituted C1). 3-20 Cycloalkylene, or optionally substituted C 3-15 Cycloalkylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 4- to 15-membered heterocyclic groups), optionally substituted aryl groups (e.g., optionally substituted C-membered heterocyclic groups). 6-10 L1 represents a linear or branched C-chain. 1-60 Alkylene (e.g., C1-C) 40 Alkylene, C1-C 30 Alkylene, C1-C 29 Alkylene, C1-C 28 Alkylene, C1-C 27 Alkylene, C1-C 26 Alkylene, C1-C 25 Alkylene, C1-C 24 Alkylene, C1-

[0115] C 23 Alkylene, C1-C 22 Alkylene, C1-C 21 Alkylene, C1-C 20 Alkylene, C1-C 19 Alkylene, C1-C 18 Alkylene, C1-C 17 Alkylene, C1-C 16 Alkylene, C1-C 15 Alkylene, C1-C 14 Alkylene, C1-C 13 Alkylene, C1-

[0116] C 12 Alkylene, C1-C 11 Alkylene, C1-C 10Alkylene, C1-C9 alkylene, C1-C8 alkylene, C1-C7 alkylene, C1-C6 alkylene, C1-C5 alkylene, C1-C4 alkylene, C1-C3 alkylene, or C1-C2 alkylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R inserted into its main carbon chain. d1 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d2 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 With R d2 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-

[0117] C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein

[0118] The group R d1 R d2 Or group Rd1 With R d2 Any combination thereof breaks one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R d1 Independently selected from O, S, N(R) d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R d3 Indicates H or C 1-3 Alkyl groups (e.g., methyl, ethyl, or propyl), and when the straight-chain or branched C-chain... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. d1 At that time, each group R d1 They are not directly connected to each other; each group R d2 Independently selected from optional substituted cycloalkylene groups (e.g., optional substituted C14-C ... 3-20 Cycloalkylene, or optionally substituted C 3-15 Cycloalkylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted arylene groups (e.g., optionally substituted C-membered heterocyclic groups). 6-10 arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenyl (e.g., C... 2-6 alkenyl), alkyneyl (e.g., C10), alkenyl), alkyneyl) 2-6 (ethynyl group) or any combination thereof;

[0119] X2 represents the key; and

[0120] R a1 Indicates NR d4 R d5 C(O)NR d6 R d7 ,NHC(O)R d8 ,NHC(O)NR d9 R d10 C(O)OR d11 OC(O)R d12 OR d13 SR d14 C(O)R d15 C(S)R d16 S(O)R d17 S(O)2R d18 S(O)2NHRd19 NHS(O)2R d20 S(O)2OR d21 OS(O)2R d22 Optional replacement of straight or branched C 1-10 Alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C14) 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted aryl groups (e.g., optionally substituted C-membered heterocyclic groups). 6-20 aryl, or optionally substituted C 6-10 Aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl), wherein R d4 R d5 R d6 R d7 R d9 R d10 R d11 R d13 R d14 R d19 and R d21 Each independently represents H, and optionally substituted straight or branched C. 1-10 Alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C14) 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C) 6-20 aryl, or optionally substituted C 6-10 aryl), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 15-membered heterocyclic groups) or optionally substituted heteroaryl groups (e.g., optionally substituted 5- to 20-membered heteroaryl groups, or optionally substituted 5- to 15-membered heteroaryl groups), and R d8 R d12 R d15 R d16 R d17 R d18 R d20 and R d22 Indicates the alternative substitution of straight or branched chains C 1-10 Alkyl, optionally substituted cycloalkyl (e.g., optionally substituted C14) 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted aryl groups (e.g., optionally substituted C-membered heterocyclic groups). 6-20aryl, or optionally substituted C 6-10 Aryl) or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl, or optionally substituted 5- to 15-membered heteroaryl); and

[0121] R b This indicates C that is optionally substituted with D or halogen. 1-60 Alkyl (e.g., C1-C) 30 Alkyl, C1-C 29 Alkyl, C1-C 28 Alkyl, C1-

[0122] C 27 Alkyl, C1-C 26 Alkyl, C1-C 25 Alkyl, C1-C 24 Alkyl, C1-C 23 Alkyl, C1-C 22 Alkyl, C1-C 21 Alkyl, C1-C 20 Alkyl, C1-C 19 Alkyl, C1-C 18 Alkyl, C1-C 17 Alkyl, C1-C 16 Alkyl, C1-C 15 Alkyl, C1-

[0123] C 14 Alkyl, C1-C 13 Alkyl, C1-C 12 Alkyl, C1-C 11 Alkyl, C1-C 10 Alkyl, C1-C9 alkyl, C1-C8 alkyl

[0124] C1-C7 alkyl, C1-C6 alkyl, C1-C5 alkyl, C1-C4 alkyl, C1-C3 alkyl, or C1-C2 alkyl), or R b The following expression is represented:

[0125] R b1 -X4-L2-,

[0126] Where L2 represents the C of the optionally substituted straight or branched chain. 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R inserted into its main carbon chain. 12 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 With R 13 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-

[0127] C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein the group R 12 R 13 Or group R 12 With R 13 Any combination thereof breaks one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 14 Independently represent H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 12 At that time, each group R 12 They are not directly connected to each other; each group R 13 Independently selected from cyclohexene alkyl groups (e.g., C10) 3-20 Cycloalkylene, or C 3-15 Cycloalkylene), heterocyclic (e.g., 4- to 20-membered heterocyclic, or 4- to 15-membered heterocyclic), aryl (e.g., C10-) 6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenyl (e.g., C... 2-6 alkenyl), alkyneyl (e.g., C10), alkenyl), alkyneyl) 2-6 (ethynyl) or any combination thereof, wherein the cycloalkylene, the heterocyclic group, the aryl group and the heteroaryl group are optionally further selected independently from D, optionally deuterated C. 1-4 Alkyl, optionally deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0128] X4 represents N(R) 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(=S), S, S(O),

[0129] S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optional substituted cycloalkylene compounds (e.g., optional substituted C... 3-20 Cycloalkylene, or optionally substituted C 3-15 Cycloalkylene, optionally substituted arylene (e.g., optionally substituted C464) 6-20 aryl, or optionally substituted C 6-10 arylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 4- to 15-membered heterocyclic groups), optionally substituted heteroarylene groups (e.g., optionally substituted 5- to 20-membered heteroarylene groups, or optionally substituted 5- to 15-membered heteroarylene groups), triazolyl-NH-, or -NH-triazolyl, wherein R 15 Indicates H or C 1-3 Alkyl, or X4, indicates a bond; and

[0130] R b1 This indicates optional substituted cycloalkyl groups (e.g., optional substituted C14 groups). 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C) 6-20 aryl, or optionally substituted C 6-10 Aryl), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 4- to 15-membered heterocyclic groups) or optionally substituted heteroaryl groups (e.g., optionally substituted 5- to 20-membered heteroaryl groups, or optionally substituted 5- to 15-membered heteroaryl groups).

[0131] In embodiments of this disclosure, the number of substituents is in principle not limited in any way or is automatically limited by the size of the building blocks.

[0132] In some embodiments of the compound of formula (I-1), R a The following expression is represented:

[0133] R a1 -X2-L1-X1-,

[0134] Where X1 represents the optional substitution of C 3-20 Cycloalkylene (e.g., optionally substituted C14) 3-15 Cycloalkyl groups), optionally substituted 4- to 20-membered nitrogen-containing heterocyclic groups (e.g., optionally substituted 4- to 15-membered nitrogen-containing heterocyclic groups), optionally substituted C 6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene);

[0135] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene (e.g., C1-C) 40 Alkylene, C1-C 30 Alkylene, C1-C 29 Alkylene, C1-C 28 Alkylene, C1-C 27 Alkylene, C1-C 26 Alkylene, C1-C 25 Alkylene, C1-C 24 Alkylene, C1-

[0136] C 23 Alkylene, C1-C 22 Alkylene, C1-C 21 Alkylene, C1-C 20 Alkylene, C1-C 19 Alkylene, C1-C 18 Alkylene, C1-C 17 Alkylene, C1-C 16 Alkylene, C1-C 15 Alkylene, C1-C 14 Alkylene, C1-C 13 Alkylene, C1-

[0137] C 12 Alkylene, C1-C 11 Alkylene, C1-C 10 Alkylene, C1-C9 alkylene, C1-C8 alkylene, C1-C7 alkylene, C1-C6 alkylene, C1-C5 alkylene, C1-C4 alkylene, C1-C3 alkylene, or C1-C2 alkylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4) inserted in its main carbon chain.

[0138] 1-3 or 1-2, or 1 group R d1 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d2And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R d1 With R d2 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-

[0139] C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein

[0140] The group R d1 R d2 Or group R d1 With R d2 Any combination thereof breaks one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R d1 Independently selected from O, S, N(R) d3 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where Rd3 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. d1 At that time, each group R d1 They are not directly connected to each other; each group R d2 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, optional deuterated C 1-6 Alkyl-NH-, Halogenated C 1-6 Alkyl, NH2-C 1-6 Alkylene, optional deuterated C 1-6 Alkyl-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- or any combination thereof are substituted, wherein the straight-chain or branched C 1-60 Alkylene and the straight-chain or branched C 2-60 Each alkylene group may be independently and optionally further selected from deuterium, or optionally deuterated C. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl groups, or any combination thereof, are substituted;

[0141] X2 represents the key; and

[0142] R a1 Indicates NR d4 R d5 C(O)NR d6 R d7 ,NHC(O)R d8 ,NHC(O)NR d9 R d10 C(O)OR d11 OC(O)R d12 ORd13 SR d14 C(O)R d15 C(S)R d16 S(O)R d17 S(O)2R d18 S(O)2NHR d19 NHS(O)2R d20 S(O)2OR d21 OS(O)2R d22 Optional replacement of straight or branched C 1-10 Alkyl, optional substituted C 3-20 Cycloalkyl (e.g., optionally substituted C) 3-15 cycloalkyl), optionally substituted 4- to 20-membered heterocyclic groups (e.g., optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted C 6-20 Aryl (e.g., optional substituted C) 6-10 aryl) or optionally substituted 5- to

[0143] 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), wherein R d4 R d5 R d6 R d7 R d9 R d10 R d11 R d13 R d14 R d19 and R d21 The same or different and each independently represents H, and optionally substituted straight or branched C. 1-10 Alkyl, optional substituted C 3-20 Cycloalkyl (e.g., optionally substituted C) 3-15 cycloalkyl), optionally substituted C 6-20 Aryl (e.g., optional substituted C) 6-10 aryl), optionally substituted 4- to 20-membered heterocyclic groups (e.g., optionally substituted 5- to 15-membered heterocyclic groups) or optionally substituted 5- to 20-membered heteroaryl groups (e.g., optionally substituted 5- to 15-membered heteroaryl groups), and R d8 R d12 R d15 R d16 R d17 R d18 R d20 and R d22 Each independently represents a linear or branched chain C with optional substitution. 1-10 Alkyl, optional substituted C 3-20 Cycloalkyl (e.g., optionally substituted C) 3-15cycloalkyl), optionally substituted 4- to 20-membered heterocyclic groups (e.g., optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted C 6-20 Aryl (e.g., optional substituted C) 6-10 Aryl) or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl).

[0144] In some embodiments of the compound of formula (I-1), X1 represents:

[0145] Optional replacement C 3-20 Cycloalkylene (e.g., optionally substituted C14) 3-15 Cycloalkyl groups), optionally substituted 4- to 20-membered nitrogen-containing monocyclic heterocyclic groups (e.g., optionally substituted 4- to 15-membered nitrogen-containing monocyclic heterocyclic groups), optionally substituted 5- to 20-membered nitrogen-containing bridged heterocyclic groups (e.g., optionally substituted 5- to 15-membered nitrogen-containing bridged heterocyclic groups), optionally substituted 5- to 20-membered nitrogen-containing spirocyclic heterocyclic groups (e.g., optionally substituted 5- to 15-membered nitrogen-containing spirocyclic heterocyclic groups), optionally substituted 5- to 20-membered nitrogen-containing fused heterocyclic groups (e.g., optionally substituted 5- to 15-membered nitrogen-containing fused heterocyclic groups), optionally substituted C 6-10 arylene, or optionally substituted 5- to 20-membered heteroarylene (e.g., optionally substituted 5- to 15-membered heteroarylene), wherein

[0146] The C 3-20 Cycloalkylene groups, the 4- to 20-membered nitrogen-containing monocyclic heterocyclic groups, the 5- to 20-membered nitrogen-containing bridged heterocyclic groups, the 5- to 20-membered nitrogen-containing spirocyclic heterocyclic groups, the 5- to 20-membered nitrogen-containing fused heterocyclic groups, and the C 6-10 The arylene and the 5- to 20-membered heteroarylene are each optionally selected independently by one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) from D, optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-

[0147] Substituents may be used to replace the substituents, or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0148] In some embodiments of the compound of formula (I-1), R a1 express:

[0149] NR d4 R d5 C(O)NR d6 R d7 ,NHC(O)R d8 ,NHC(O)NR d9 R d10 C(O)OR d11 OC(O)R d12 OR d13 SR d14 C(O)R d15 C(S)R d16 S(O)R d17 S(O)2R d18 S(O)2NHR d19 NHS(O)2R d20 S(O)2OR d21 OS(O)2R d22 Optional replacement of straight or branched C 1-10 Alkyl, optional substituted C 3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclic groups, optionally substituted C 6-20aryl or optionally substituted 5- to 20-membered heteroaryl groups, wherein the straight-chain or branched C 1-10 Alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclic group, the C 6-20 The aryl group or each of the 5- to 20-membered heteroaryl groups is independently and optionally selected from D, optionally deuterated C, by one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-, and optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, optionally substituted 4- to 15-membered heterocyclic group, optionally substituted 5- to 15-membered heteroaryl group, or any combination thereof are substituents;

[0150] Where R d4 R d5 R d6 R d7 R d9R d10 R d11 R d13 R d14 R d19 and R d21 Each independently represents H, and optionally substituted straight or branched C. 1-10 Alkyl, optional substituted C 3-20 cycloalkyl, optional substituted C 6-20 Aryl, optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 20-membered heteroaryl groups, wherein the straight-chain or branched C 1-10 Alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclic group, the C 6-20 The aryl group or each of the 5- to 20-membered heteroaryl groups is independently and optionally selected from D, optionally deuterated C, by one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-

[0151] C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl groups -C(O)NH-, such as CH3-C(O)NH-, CH3CH2-

[0152] C(O)NH-, and CH3CH2CH2-C(O)NH-), optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, with substituent substitution; and

[0153] R d8 R d12 R d15 R d16 R d17 R d18 R d20 and R d22 Each can be used independently to represent a straight or branched chain with alternative substitutions.

[0154] C 1-10 Alkyl, optional substituted C 3-20 cycloalkyl, optionally substituted 4- to 20-membered heterocyclic groups, optionally substituted C 6-20 aryl or optionally substituted 5- to 20-membered heteroaryl groups, wherein the straight-chain or branched C 1-10 Alkyl, the C 3-20 cycloalkyl, the 4- to 20-membered heterocyclic group, the C 6-20 The aryl group or each of the 5- to 20-membered heteroaryl groups is independently and optionally selected from D, optionally deuterated C, by one or more (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, and halogenated C. 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-,

[0155] CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-

[0156] For example, CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), C 1-4 alkyl-

[0157] C(O)NH- (e.g., C) 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-, and optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The substituents may be aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0158] In some embodiments of the compound of formula (I-1), X1 represents:

[0159] Cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[5.5]undecaneylene, p-menthaneylene, m-Menthyl, quinoline, adamantyl, borneolyl, bicyclo[2.2.1]heptane, 2-oxobicyclo[2.2.1]heptane, or bicyclo[2.2.1]heptene, optionally by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) selected from D, optionally deuterated C 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are used for substitution;

[0160] Phenylidene or naphthylene, optionally selected from D, optionally deuterated C by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups. 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 alkyl-

[0161] C(O)NH- or any combination thereof are substituents;

[0162] Azahexacyclic butyl, pyrrolidine, imidazoalkyl, pyrazolidine, oxazolidine, thiazoalkyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, azahexacyclic heptanediol, azahexacyclic octanediol, diazaheptanediol, diazaheptanediol, 3-azabicyclo[3.1.0]hexanediol, 6-azabicyclo[3.1.1]heptanediol, 2,5-diazabicyclo[2.2.1]heptanediol, 3,6-diazabicyclo[3.1.1]heptanediol, 3-azabicyclo[3.2.1]

[0163] Octane derivative, 3,8-diazabicyclo[3.2.1]octane derivative, 2,5-diazabicyclo[2.2.2]octane derivative, 3-azaspiro[3.2.1]octane derivative

[0164] [5.5]undecanediol or 7-azaspiro[3.5]nonanediol, optionally surrounded by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) selected from D, optionally deuterated C 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4Alkyl-C(O)NH-, or any combination thereof, substituents; or imidinyl, imoxazolyl, imoxazolyl, imoxadiazolyl, imoxenyl, imoxazolyl, imoxazolyl, imoxadi ...

[0165] [1,2,3]thiadiazolyl, quinolineyl, isoquinolineyl, naphthidyl, cyclophosphinyl, quinolineyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidineyl, imidazo[1,2-a]pyridinyl, 1H-pyrrolo[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, 4H-fluoro[3,2-b]pyrroloyl, pyrrolo[2,1-b]thiazoleyl and imidazo[2,1-b]thiazoleyl, optionally selected from D, optionally deuterated C. 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substituents of alkyl-C(O)NH- or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0166] In some embodiments of the compound of formula (I-1), R a1 express

[0167] NR d4 R d5 C(O)NR d6 R d7 ,NHC(O)R d8 ,NHC(O)NR d9 R d10 C(O)OR d11 OC(O)R d12 OR d13 SR d14 C(O)Rd15 C(S)R d16 S(O)R d17 S(O)2R d18 S(O)2NHR d19 NHS(O)2R d20 S(O)2OR d21 or OS(O)2R d22 ,

[0168] Where R d4 R d5 R d6 R d7 R d9 R d10 R d11 R d13 R d14 R d19 and R d21 Same or different and each independently represented:

[0169] H, or

[0170] Methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, pteropentyl, hexyl, heptyl, octyl, nonyl, or decyl, optionally with one or more

[0171] (For example, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) Choose freely (D), or optionally (C) deuteration. 1-4 Alkyl, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy,

[0172] C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 alkyl

[0173] -C(O)NH-, optional substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of the group consisting of alkylene groups or any combination thereof; or cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[3 ...3]octyl, spiro[3.4]octyl, spiro[3.3]heptyl, spiro[3.4]octyl, spiro[3

[0174] [3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthyl, m-menthyl, quininecycloyl, adamantyl, noradamantyl, borneol, bicyclo[2.2.1]heptyl, or bicyclo[2.2.1]heptenyl, optionally surrounded by one or more (e.g., 1-10, 1-9, 1-8, 1-7, ...

[0175] (1-6, 1-5, 1-4, 1-3 or 1-2, or 1) Choose freely (D), or optionally (C) deuteration. 1-4 Alkyl, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4Substituents of alkylene groups or any combination thereof; or

[0176] Phenyl or naphthyl, optionally with one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) selected from optionally deuterated C 1-4 Alkyl, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0177] Azacyclobutyl, oxacyclobutyl, pyrrolyl, imidazoalkyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolyl, thiazoalkyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo

[0178] [3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octane, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), optionally selected from D by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) of C, optionally deuterated C. 1-4 Alkyl, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-

[0179] C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof;

[0180] Furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indoleyl, benzimidazolyl, benzooxazolyl, benzoisooxazolyl, benzothiazolyl, benzotriazolyl Azolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphridinyl, cenolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridinyl, 1H-pyrrolo[3,2-b]pyridinyl,

[0181] 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolo, pyrrolo[2,1-b]thiazolyl, or imidazolyl

[0182] [2,1-b]thiazolyl, which is optionally surrounded by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, ...) groups.

[0183] (1-4, 1-3, or 1-2, or 1) Choose freely (D), or optionally (C) deuteration. 1-4 Alkyl, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally substituted by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, ...)

[0184] 1-5, 1-4, 1-3, or 1-2, or 1) are selected from D, halogen, hydroxyl, cyano, amino, mercapto, and C. 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; and

[0185] R d8 R d12 R d15 R d16 R d17 R d18 R d20 and R d22 Each is expressed independently:

[0186] Methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, pteropentyl, hexyl, heptyl, octyl, nonyl, or decyl, optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0187] Cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.3]heptyl, spiro[3.3]oct ...

[0188] [3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthyl, m-menthyl, quininecycloyl, adamantyl, noradamantyl, borneol, bicyclo[2.2.1]heptyl, or bicyclo[2.2.1]heptenyl, optionally surrounded by one or more (e.g., 1-10, 1-9, 1-8, 1-7, ...

[0189] 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) are selected from D, halogen, hydroxyl, cyano, amino, mercapto, and C. 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0190] Phenyl or naphthyl, optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) free from halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 alkyl-

[0191] C(O)NH-, optional substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C1-4 Substituents of the group consisting of alkylene groups or any combination thereof; or aziridine, oxaziridine, pyrrolidine, imidazoalkyl, pyrazolidine, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolidine, thiazoalkyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, aziridine heptyl, aziridine octyl, diazacycloheptyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo

[0192] [3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octane, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocycloyl (e.g., 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl), optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-

[0193] Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof;

[0194] Furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrroleyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indoleyl, benzimidazolyl, benzooxazolyl, benzoisooxazolyl, benzothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]oxadiazolyl 3] Thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphridyl, cenolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazolyl

[0195] [2,1-b]thiazolyl, optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-

[0196] C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof;

[0197] In some embodiments of the compound of formula (I-1), R a1 express:

[0198] Methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, pentyl, isopentyl, neopentyl, pteropentyl, hexyl, heptyl, octyl, nonyl, or decyl, optionally with one or more (e.g., 1-10, 1-9)

[0199] 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) are selected from D, halogen, hydroxyl, cyano, amino, mercapto, and C. 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 alkyl-

[0200] NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally substituted by one or more (e.g., 1-10, 1-9, ...)

[0201] 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) are selected from D, halogen, hydroxyl, cyano, amino, mercapto, and C. 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0202] Cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]

[0203] Nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthyl, m-menthyl, quininecycloyl, adamantyl, noradamantyl, borneol, bicyclo[2.2.1]heptyl, or bicyclo[2.2.1]heptenyl, optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0204] Phenyl or naphthyl, optionally selected by one or more (e.g., 1-5, 1-4, 1-3, or 1-2, or 1) from halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene

[0205] C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15cycloalkyl, optional substituted C 6-10 The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of alkylene groups or any combination thereof; or

[0206] Azacyclobutyl, oxacyclobutyl, pyrrolidinyl, imidazoalkyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolyl, thiazoalkyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxacyclohexyl, azacycloheptyl, azacyclooctyl, diazacycloheptyl, diazacyclooctyl, 3-azabicyclo[3.1.0]hexyl, 6-azabicyclo[3.1.0]hexyl Bicyclic [3.1.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octane, 2,5-diazabicyclo[2.2.2]octyl, or azaspirocyclic (e.g., 3-azaspiro[5.5]undecyl or 7-azaspirocyclic).

[0207] [3.5]Nonyl), optionally selected by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 alkyl-

[0208] NH-, halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-,

[0209] Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of the group consisting of alkylene groups or any combination thereof; or furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thienyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrroleyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiopheneyl, inzolyl, benzimidazolyl, benzooxazolyl, benzoisooxazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthinyl The radical, pyrazolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrrolyl, pyrrolo[2,1-b]thiazolyl or imidazo[2,1-b]thiazolyl, optionally selected from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-

[0210] Optional replacement C 3-15 cycloalkyl, optional substituted C 6-10 Substituents comprising the group consisting of aryl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted 5- to 15-membered heteroaryl groups, or any combination thereof, wherein the optionally substituted C 3-15 cycloalkyl, optional substituted C 6-10The aryl group, the optionally substituted 4- to 15-membered heterocyclic group, and the optionally substituted 5- to 15-membered heteroaryl group are each independently and optionally selected from one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) free from D, halogen, hydroxyl, cyano, amino, mercapto, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Substituents of the group consisting of alkylene groups or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0211] In some embodiments of the compound of formula (I-1), X1 represents:

[0212]

[0213]

[0214] The symbol # indicates the connection point with group L1.

[0215] In some embodiments of the compound of formula (I-1), R a1 It represents a hydroxyl group.

[0216] In some embodiments of the compound of formula (I-1), R a1 express:

[0217]

[0218]

[0219] In some embodiments of the compound of formula (I-1), L1 represents the structure of the following formula:

[0220] ##-(C(R a1 (R) a2 )) m1 -(R d1 (C(R a3 (R) a4 )) m2 ) p1 -;

[0221] ##-(C(R a1 (R) a2 )) m1 -(R d1 (C(R a3 (R) a4 )) m2 ) p1 -(Rd1 (C(R a5 )(R a6 )) m3 ) p2 -;

[0222] ##-(C(R a1 )(R a2 )) m1 -(R d1 (C(R a3 )(R a4 )) m2 ) p1 -(R d1 (C(R a5 )(R a6 )) m3 ) p2 -(R d1 (C(R a7 )(R a8 )) m4 ) p3 -;

[0223] ##-(C(R a1 )(R a2 )) m1 -(R d2 (C(R a3 )(R a4 )) m2 ) p1 -;

[0224] ##-(C(R a1 )(R a2 )) m1 -(R d2 (C(R a3 )(R a4 )) m2 ) p1 -(R d2 (C(R a5 )(R a6 )) m3 ) p2 -;

[0225] ##-(C(R a1 )(R a2 )) m1 -(R d2 (C(R a3 )(R a4 )) m2 ) p1 -(R d2 (C(R a5 )(R a6 )) m3 )p2 -(R d2 (C(R a7 (R) a8 )) m4 ) p3 -;

[0226] ##-(C(R a1 (R) a2 )) m1 -(R d1 -R d2 -(C(R a3 (R) a4 )) m2 ) p1 -;

[0227] ##-(C(R a1 (R) a2 )) m1 -(R d1 (C(R a3 (R) a4 )) m2 ) p1 -(R d2 (C(R a5 (R) a6 )) m3 ) p2 -;

[0228] ##-(C(R a1 (R) a2 )) m1 -(R d2 -R d1 -(C(R a3 (R) a4 )) m2 ) p1 -;or

[0229] ##-(C(R a1 (R) a2 )) m1 -(R d2 (C(R a3 (R) a4 )) m2 ) p1 -(R d1 (C(R a5 (R) a6 )) m3 ) p2 -;

[0230] Among them, each group R d1 Independently selected from O, S, N(R) d3), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where each R d3 Independently represent H or C 1-3 Alkyl groups; R groups d2 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkyl groups (e.g., methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-6 Alkyl halide C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-3 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C 1-6 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, optionally deuterated C1-6 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof, are substituted with substituents;

[0231] R a1 R a2 R a3 R a4 R a5 R a6 R a7 and R a8 Each group independently represents H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, and optionally deuterated C. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, and halogenated C. 1-6 Alkyl halide C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-, optionally deuterated C 3-6 Cycloalkyl groups (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkyl groups (e.g., methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-3 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C 1-6 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- (e.g., C 1-3Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof;

[0232] The symbol ## indicates the connection point with group X1; and

[0233] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0234] In some embodiments of the compound of formula (I-1), L1 represents the structure of the following formula:

[0235] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -;

[0236] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -(O(C(R a5 (R) a6 )) m3 ) p2 -;

[0237] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -(O(C(R a5 (R) a6 )) m3 ) p2 -(O(C(R a7 (R) a8 )) m4 ) p3 -;

[0238] ##-(C(R a1 (R) a2 )) m1 -(N(R g9 )(C(R a3 (R)a4 )) m2 ) p1 -;

[0239] ##-(C(R a1 )(R a2 )) m1 -(N(R g9 )(C(R a3 )(R a4 )) m2 ) p1 -(N(R g9 )(C(R a5 )(R a6 )) m3 ) p2 -;

[0240] ##-(C(R a1 )(R a2 )) m1 -(N(R g9 )(C(R a3 )(R a4 )) m2 ) p1 -(N(R g9 )(C(R a5 )(R a6 )) m3 ) p2 -(N(R g9 )(C(R a7 )(R a8 )) m4 ) p3 -;

[0241] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -;

[0242] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(C(O)NH-(C(R a5 )(R a6 )) m3 ) p2 -;

[0243] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(C(O)NH-(C(R a5 )(R a6 )) m3 ) p2 -(C(O)NH-(C(R a7 )(R a8 )) m4 ) p3 -;

[0244] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(O-(C(R a5 )(R a6 )) m3 ) p2 -;

[0245] ##-(C(R a1 )(R a2 )) m1 -C(O)NH-(C(R a3 )(R a4 )) m2 -(O(C(R a5 )(R a6 )) m3 ) p1 -;

[0246] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 ) p1 -;

[0247] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 ) p1 -(O-(C(R a5)(R a6 )) m3 ) p2 -;

[0248] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 ) p1 -(O-(C(R a5 )(R a6 )) m3 ) p2 -(O-(C(R a7 )(R a8 )) m4 ) p3 -;

[0249] ##-(C(R a1 )(R a2 )) m1 -NHC(O)-(C(R a3 )(R a4 )) m2 -(O(C(R a5 )(R a6 )) m3 ) p1 -;

[0250] ##-(C(R a1 )(R a2 )) m1 -NHC(O)NH-(C(R a3 )(R a4 )) m2 -;

[0251] ##-(C(R a1 )(R a2 )) m1 -C(O)-(C(R a3 )(R a4 )) m2 -;

[0252] ##-(C(R a1 )(R a2 )) m1 -C(S)-(C(R a3 )(R a4 )) m2 -;

[0253] ##-(C(R a1 )(R a2 ))m1 -S-(C(R a3 (R) a4 )) m2 -;

[0254] ##-(C(R a1 (R) a2 )) m1 -(C 6-10 Aspartic-(C(R) a3 (R) a4 )) m2 ) p1 -;

[0255] ##-(C(R a1 (R) a2 )) m1 -(C 6-10 Aspartic-(C(R) a3 (R) a4 )) m2 ) p1 -C 6-10 Aspartic-(C(R) a5 (R) a6 )) m3 -;

[0256] ##-(C(R a1 (R) a2 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a3 (R) a4 )) m2 ) p1 -;

[0257] ##-(C(R a1 (R) a2 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a3 (R) a4 )) m2 ) p1 -(4-to-15-membered heterocyclic group-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0258] ##-(C(R a1 (R) a2 )) m1 -(5-to-15-methylheteroaryl-(C(R) a3 (R) a4 )) m2 ) p1 -;

[0259] ##-(C(R a1 (R) a2 )) m1 -(5-to-15-methylheteroaryl-(C(R) a3 (R) a4 )) m2 ) p1 -(5-to-15-methylheteroaryl-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0260] ##-(C(R a1 (R) a2 )) m1 -(C 3-15 Cycloalkylene-(C(R) a3 (R) a4 )) m2 ) p1 -;or

[0261] ##-(C(R a1 (R) a2 )) m1 -(C 3-15 Cycloalkylene-(C(R) a3 (R) a4 )) m2 ) p1 -(C 3-15 Cycloalkylene-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0262] Among them, each R g9 Independently represent H or C 1-3 alkyl;

[0263] The C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, optional deuterated C 1-6 Alkoxy, optional deuterated C 1-6 Alkyl-NH-, Halogenated C 1-6 Alkyl, NH2-C 1-6 Alkylene, optional deuterated C 1-6 Alkyl-NHC(O)-, optionally deuterated C1-6 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0264] R a1 R a2 R a3 R a4 R a5 R a6 R a7 and R a8 Each group independently represents H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, and optionally deuterated C. 1-6 Alkyl, Halogenated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, optional deuterated C 1-6 Alkoxy, optional deuterated C 1-6 Alkyl-NH-, NH2-C 1-6 Alkylene, optional deuterated C 1-6 Alkyl-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- or any combination thereof;

[0265] The symbol ## indicates the connection point with group X1; and

[0266] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0267] In some embodiments of the compound of formula (I-1), L1 represents the following groups:

[0268] ##-CH2-O-CH2-, ##-CH2-O-(CH2)2-, ##-(CH2)1-O-(CH2)3-, ##-(CH2)1-O-(CH2)4-, ##-(CH2)1-O-(CH2)5-, ##- (CH2)1-O-(CH2)6-, ##-(CH2)1-O-(CH2)7-, ##-(CH2)1-O-(CH2)8-, ##-(CH2)1-O-(CH2)9-, ##-(CH2)1-O-(CH2) 10-, ##-(CH2)2-O-(CH2)1-, ##-(CH2)2-O-(CH2)2-, ##-(CH2)2-O-(CH2)3-, ##-(CH2)2-O-(CH2)4-, ##-(CH2)2-O-(CH2)5-, ##-(CH2)2-O-(CH2)6-, ##-(CH2)2-O-(CH2)7-, ##-(CH2)2-O-(CH2)8-, ##-(CH2)2-O-(CH2)9-, ##-(CH2)2-O-(CH2) 10 -##-(CH2)2-O-(CH2) 11 -##-(CH2)2-O-(CH2) 12-##-(CH2)3-O-(CH2)1-##-(CH2)3-O-(CH2)2-##-(CH2)3-O-(CH2)3-##-(CH2)3-O-(CH2)4-##-(CH2)3-O-(CH2)5-##-(CH2)3-O-(CH2)6-##-(CH2)3-O-(CH2)7-##-(CH2)4-O-(CH2)1-##-(CH2)4-O-(CH2)2-##-(C H2)4-O-(CH2)3-、##-(CH2)4-O-(CH2)4-、##-(CH2)4-O-(CH2)5-、##-(CH2)4-O-(CH2)6-、##-(CH2)5-O-(CH2)1 -、##-(CH2)5-O-(CH2)2-、##-(CH2)5-O-(CH2)3-、##-(CH2)5-O-(CH2)4-、##-(CH2)5-O-(CH2)5-、##-(CH2)6-O- (CH2)1-, ##-(CH2)6-O-(CH2)2-, ##-(CH2)6-O-(CH2)3-, ##-(CH2)6-O-(CH2)4-, ##-(CH2)7-O-(CH2)1-, ##-(CH2)7-O-(CH2)2-, ##-(CH2)7-O-(CH2)3-, ##-(CH2)8-O-(CH2)1-, ##-(CH2)8-O-(CH2)2-, ##-CH(CH3)-O-(CH2)1 -, ##-CH(CH3)-O-(CH2)2-, ##-CH(CH3)-O-(CH2)3-, ##-CH(CH3)-O-(CH2)4-, ##-CH(CH3)-O-(CH2)5-, ##-CH(CH3)-O-(CH2)6-, ##-CH(CH3)-O-(CH2)7-, ##-CH(CH3)-O-(CH2)8-, ##-CH(CH3)-O-(CH2)9-, ##-CH(CH3)-O-(CH2) 10 -, ##-CH2-(O(CH2)2)2-, ##-CH2-(O(CH2)2)3-, ##-CH2-(O(CH2)2)4-, ##-CH2-(O(CH2)2)5-, ##-CH2-(O(CH2)2)6-, ##-CH2-(O(CH2)2)7-, ##-CH2-(O(CH2)2)8-, ##-CH2-(O(CH2)2)9-, ##-CH2-(O(CH2)2) 10-、##-CH2-(O(CH2)2)1-OCH2-、##-CH2-(O(CH2)2)2-OCH2-、##-CH2-(O(CH2)2)3-OCH2-、##-CH2-(O(CH2)2)4-OCH2-、##-CH2-(O(CH2)2)5-OCH2-、##-CH2-(O(CH2)2)6-OCH2-、##-CH2-(O(CH2)2)7-OCH2-、##-CH2-(O(CH2)2)8-OCH2-、##-CH2-(O(CH2)2)9-OCH2-、##-CH2-(O(CH2)2) 10 -OCH2-、##-(CH2)2-(O(CH2)2)2-、##-(CH2)2-(O(CH2)2)3-、##-(CH2)2-(O(CH2)2)4-、##-(CH2)2-(O(CH2)2)5-、##-(CH2)2-(O(CH2)2)6-、##-(CH2)2-(O(CH2)2)7-、##-(CH2)2-(O(CH2)2)8-、##-(CH2)2-(O(CH2)2)9-、##-(CH2)2-(O(CH2)2) 10 -、##-(CH2)3-(O(CH2)2)2-、##-(CH2)3-(O(CH2)2)3-、##-(CH2)3-(O(CH2)2)4-、##-(CH2)3-(O(CH2)2)5-、##-(CH2)3-(O(CH2)2)6-、##-(CH2)3-(O(CH2)2)7-、##-(CH2)3-(O(CH2)2)8-、##-(CH2)3-(O(CH2)2)9-、##-(CH2)3-(O(CH2)2) 10 -、##-(CH2)4-(O(CH2)2)2-、##-(CH2)4-(O(CH2)2)3-、##-(CH2)4-(O(CH2)2)4-、##-(CH2)4-(O(CH2)2)5-、##-(CH2)4-(O(CH2)2)6-、##-(CH2)4-(O(CH2)2)7-、##-(CH2)4-(O(CH2)2)8-、##-(CH2)4-(O(CH2)2)9-、##-(CH2)4-(O(CH2)2) 10-, ##-CH2-(O(CH2)3)2-, ##-CH2-(O(CH2)3)3-, ##-CH2-(O(CH2)3)4-, ##-CH2-(O(CH2)3)5-, ##-CH2-(O(CH2)3)6-, ##-CH2-(O(CH2)3)7-, ##-CH2-(O(CH2)3)8-, ##-CH2-(O(CH2)3)9-, ##-CH2-(O(CH2)3) 10 -, ##-(CH2)2-(O(CH2)3)2-, ##-(CH2)2-(O(CH2)3)3-, ##-(CH2)2-(O(CH2)3)4-, ##-(CH2)2-(O(CH2)3)5-, ##-(CH2)2-(O(CH2)3)6-, ##-(CH2)2-(O(CH2)3)7-, ##-(CH2)2-(O(CH2)3)8-, ##-(CH2)2-(O(CH2)3)9-, ##-(CH2)2-(O(CH2)3) 10 -, ##-(CH2)3-(O(CH2)3)2-, ##-(CH2)3-(O(CH2)3)3-, ##-(CH2)3-(O(CH2)3)4-, ##-(CH2)3-(O(CH2)3)5-, ##-(CH2)3-(O(CH2)3)6-, ##-(CH2)3-(O(CH2)3)7-, ##-(CH2)3-(O(CH2)3)8-, ##-(CH2)3-(O(CH2)3)9-, ##-(CH2)3-(O(CH2)3) 10-##-CH2-O-(CH2)2-O-(CH2)3-##-CH2-(O(CH2)2)2-(O(CH2)3)2-##-CH2-(O(CH2)2)3-(O(CH2)3)3-##-CH2-(O(CH2)2)4-(O(CH2)3)4-##-CH2-(O(CH2)2)5-(O(CH2)3)5-##-CH2-(O(CH2)2)6-(O(CH2)3)6-##-(CH2)2-O-(CH2)2-O-(CH2)3-##-(CH2)3-##-(CH2)2 -(O(CH2)2)3-(O(CH2)3)3-、##-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-、##-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-、##-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-、##-(CH2)3-O-(CH2)2-O-(CH2)3-、##-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-、##-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-、##-(CH2)3-(O(CH2)2)4-(O(CH2)3)4- 、##-(CH2)3-(O(CH2)2)5-(O(CH2)3)5-、##-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-、##-CH2-O-(CH2)3-O-(CH2)2-、##-CH2-(O(CH2)3)2-(O(CH2)2)2-、##-CH2-(O(CH2)3)3-(O(CH2)2)3-、##-CH2-(O(CH2)3)4-(O(CH2)2)4-、##-CH2-(O(CH2)3)5-(O(CH2)2)5-、##-CH2-(O(CH2)3)6-(O(CH2)2)6-、##-(CH 2)2-O-(CH2)3-O-(CH2)2-,##-(CH2)2-(O(CH2)3)2-(O(CH2)2)2-,##-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-,##-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-,##-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-,##-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-,##-(CH2)3-O-(CH2)3-O-(CH2)2-,##-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-,##-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-、##-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-、##-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-、##-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-、##-CH2 -O-(CH2)2-O-CH2-,##-(CH2)2-O-(CH2)2-O-CH2-,##-(CH2)2-(O(CH2)2)2-O-(CH2)3-,##-(CH2)2-(O(CH2)2)3-O-(CH2)3-,##-(CH2)2-(O(CH2)2)4-O-(CH2)3-,##- (CH2)5-(O(CH2)2)2-O-(CH2)5-, ##-(CH2)5-(O(CH2)2)2-O-(CH2)6-, ##-CH2-C(O)-CH2-, ##-CH2-C(O)-(CH2)2-, ##-(CH2)1-C(O)-(CH2)3-, ##-(CH2)1-C(O)-(CH2) 4-, ##-(CH2)1-C(O)-(CH2)5-, ##-(CH2)1-C(O)-(CH2)6-, ##-(CH2)1-C(O)-(CH2)7-, ##-(CH2)1-C(O)-(CH2)8-, ##-(CH2)1-C(O)-(CH2)9-, ##-(CH2)1-C(O)-(CH2) 10 -, ##-(CH2)2-C(O)-(CH2)1-, ##-(CH2)2-C(O)-(CH2)2-, ##-(CH2)2-C(O)-(CH2)3-, ##-(CH2)2-C(O)-(CH2)4-, ##-(CH2)2-C(O)-(CH2)5-, ##-(CH2)2-C(O)-(CH2)6-, ##-(CH2)2-C(O)-(CH2)7-, ##-(CH2)2-C(O)-(CH2)8-, ##-(CH2)2-C(O)-(CH2)9-, ##-(CH2)2-C(O)-(CH2) 10 -##-(CH2)2-C(O)-(CH2) 11 -##-(CH2)2-C(O)-(CH2) 12-、##-(CH2)3-C(O)-(CH2)1-、##-(CH2)3-C(O)-(CH2)2-、##-(CH2)3-C(O)-(CH2)3-、##-(CH2)3-C(O)-(CH2)4-、##-(CH2)3-C(O)-(CH2)5-、##-(CH2)3-C(O)-(CH2)6-、##-(CH2)3-C(O)-(CH2)7-、##-(CH2)4-C(O)-(CH2)1-、##-(CH2)4-C(O)-(CH2)2-、##-(CH2)4-C(O)-(CH2)3-、##-(CH2)4-C(O)-(CH2)4-、##-(CH2)4-C(O)-(CH2)5-、##-(CH2)4-C(O)-(CH2)6-、##-(CH2)5-C(O)-(CH2)1-、##-(CH2)5-C(O)-(CH2)2-、##-(CH2)5-C(O)-(CH2)3-、##-(CH2)5-C(O)-(CH2)4-、##-(CH2)5-C(O)-(CH2)5-、##-(CH2)6-C(O)-(CH2)1-、##-(CH2)6-C(O)-(CH2)2-、##-(CH2)6-C(O)-(CH2)3-、##-(CH2)6-C(O)-(CH2)4-、##-(CH2)7-C(O)-(CH2)1-、##-(CH2)7-C(O)-(CH2)2-、##-(CH2)7-C(O)-(CH2)3-、##-(CH2)8-C(O)-(CH2)1-、##-(CH2)8-C(O)-(CH2)2-、##-CH2-S-CH2-、##-CH2-S-(CH2)2-、##-(CH2)1-S-(CH2)3-、##-(CH2)1-S-(CH2)4-、##-(CH2)1-S-(CH2)5-、##-(CH2)1-S-(CH2)6-、##-(CH2)1-S-(CH2)7-、##-(CH2)1-S-(CH2)8-、##-(CH2)1-S-(CH2)9-、##-(CH2)1-S-(CH2) 10-、##-(CH2)2-S-(CH2)1-、##-(CH2)2-S-(CH2)2-、##-(CH2)2-S-(CH2)3-、##-(CH2)2-S-(CH2)4-、##-(CH2)2-S-(CH2)5-、##-(CH2)2-S-(CH2)6-、##-(CH2)2-S-(CH2)7-、##-(CH2)2-S-(CH2)8-、##-(CH2)2-S-(CH2)9-、##-(CH2)2-S-(CH2) 10 -、##-(CH2)2-S-(CH2) 11 -、##-(CH2)2-S-(CH2) 12-、##-(CH2)3-S-(CH2)1-、##-(CH2)3-S-(CH2)2-、##-(CH2)3-S-(CH2)3-、##-(CH2)3-S-(CH2)4-、##-(CH2)3-S-(CH2)5-、##-(CH2)3-S-(CH2)6-、##-(CH2)3-S-(CH2)7-、##-(CH2)4-S-(CH2)1-、##-(CH2)4-S-(CH2)2-、##-(CH2)4-S-(CH2)3-、##-(CH2)4-S-(CH2)4-、##-(CH2)4-S-(CH2)5-、##-(CH2)4-S-(CH2)6-、##-(CH2)5-S-(CH2)1-、##-(CH2)5-S-(CH2)2-、##-(CH2)5-S-(CH2)3-、##-(CH2)5-S-(CH2)4-、##-(CH2)5-S-(CH2)5-、##-(CH2)6-S-(CH2)1-、##-(CH2)6-S-(CH2)2-、##-(CH2)6-S-(CH2)3-、##-(CH2)6-S-(CH2)4-、##-(CH2)7-S-(CH2)1-、##-(CH2)7-S-(CH2)2-、##-(CH2)7-S-(CH2)3-、##-(CH2)8-S-(CH2)1-、##-(CH2)8-S-(CH2)2-、##-CH2-C(S)-CH2-、##-CH2-C(S)-(CH2)2-、##-(CH2)1-C(S)-(CH2)3-、##-(CH2)1-C(S)-(CH2)4-、##-(CH2)1-C(S)-(CH2)5-、##-(CH2)1-C(S)-(CH2)6-、##-(CH2)1-C(S)-(CH2)7-、##-(CH2)1-C(S)-(CH2)8-、##-(CH2)1-C(S)-(CH2)9-、##-(CH2)1-C(S)-(CH2) 10-、##-(CH2)2-C(S)-(CH2)1-、##-(CH2)2-C(S)-(CH2)2-、##-(CH2)2-C(S)-(CH2)3-、##-(CH2)2-C(S)-(CH2)4-、##-(CH2)2-C(S)-(CH2)5-、##-(CH2)2-C(S)-(CH2)6-、##-(CH2)2-C(S)-(CH2)7-、##-(CH2)2-C(S)-(CH2)8-、##-(CH2)2-C(S)-(CH2)9-、##-(CH2)2-C(S)-(CH2) 10 -、##-(CH2)2-C(S)-(CH2) 11 -、##-(CH2)2-C(S)-(CH2) 12-、##-(CH2)3-C(S)-(CH2)1-、##-(CH2)3-C(S)-(CH2)2-、##-(CH2)3-C(S)-(CH2)3-、##-(CH2)3-C(S)-(CH2)4-、##-(CH2)3-C(S)-(CH2)5-、##-(CH2)3-C(S)-(CH2)6-、##-(CH2)3-C(S)-(CH2)7-、##-(CH2)4-C(S)-(CH2)1-、##-(CH2)4-C(S)-(CH2)2-、##-(CH2)4-C(S)-(CH2)3-、##-(CH2)4-C(S)-(CH2)4-、##-(CH2)4-C(S)-(CH2)5-、##-(CH2)4-C(S)-(CH2)6-、##-(CH2)5-C(S)-(CH2)1-、##-(CH2)5-C(S)-(CH2)2-、##-(CH2)5-C(S)-(CH2)3-、##-(CH2)5-C(S)-(CH2)4-、##-(CH2)5-C(S)-(CH2)5-、##-(CH2)6-C(S)-(CH2)1-、##-(CH2)6-C(S)-(CH2)2-、##-(CH2)6-C(S)-(CH2)3-、##-(CH2)6-C(S)-(CH2)4-、##-(CH2)7-C(S)-(CH2)1-、##-(CH2)7-C(S)-(CH2)2-、##-(CH2)7-C(S)-(CH2)3-、##-(CH2)8-C(S)-(CH2)1-、##-(CH2)8-C(S)-(CH2)2-、##-CH2-C(O)O-CH2-、##-CH2-C(O)O-(CH2)2-、##-(CH2)1-C(O)O-(CH2)3-、##-(CH2)1-C(O)O-(CH2)4-、##-(CH2)1-C(O)O-(CH2)5-、##-(CH2)1-C(O)O-(CH2)6-、##-(CH2)1-C(O)O-(CH2)7-、##-(CH2)1-C(O)O-(CH2)8-、##-(CH2)1-C(O)O-(CH2)9-、##-(CH2)1-C(O)O-(CH2) 10-, ##-(CH2)2-C(O)O-(CH2)1-, ##-(CH2)2-C(O)O-(CH2)2-, ##-(CH2)2-C(O)O-(CH2)3-, ##-(CH2)2-C(O)O-(CH2)4-, ##-(CH2)2-C(O)O-(CH2)5-, ##-(CH2)2-C(O)O-(CH2)6-, ##-(CH2)2-C(O)O-(CH2)7-, ##-(CH2)2-C(O)O-(CH2)8-, ##-(CH2)2-C(O)O-(CH2)9-, ##-(CH2)2-C(O)O-(CH2) 10 -##-(CH2)2-C(O)O-(CH2) 11 -##-(CH2)2-C(O)O-(CH2) 12-, ##-(CH2)3-C(O)O-(CH2)1-, ##-(CH2)3-C(O)O-(CH2)2-, ##-(CH2)3-C(O)O-(CH2)3-, ##-(CH2)3-C(O)O-(CH2)4-, ##-(CH2)3-C(O)O-(CH2)5-, ##-(CH2)3-C(O)O-(CH2)6-, ##-(CH2)3-C(O)O-(CH2)7-, ##-(CH2)4-C(O)O-(CH2)1-, ##-(CH2)4-C(O)O-(CH2)2-, # #-(CH2)4-C(O)O-(CH2)3-, ##-(CH2)4-C(O)O-(CH2)4-, ##-(CH2)4-C(O)O-(CH2)5-, ##-(CH2)4-C(O)O-(CH2)6-, ##-(CH2)5-C(O)O-(CH2)1-, ##-(CH2)5-C(O)O-(CH2)2-, ##-(CH2)5-C(O)O-(CH2)3-, ##-(CH2)5-C(O)O-(CH2)4-, ##-(CH2)5-C(O)O-(CH2)5-, ##-(C H2)6-C(O)O-(CH2)1-, ##-(CH2)6-C(O)O-(CH2)2-, ##-(CH2)6-C(O)O-(CH2)3-, ##-(CH2)6-C(O)O-(CH2)4-, ##-(CH2)7-C(O)O-(CH2)1-, ##-(CH2)7-C(O)O-(CH2)2-, ##-(CH2)7-C(O)O-(CH2)3-, ##-(CH2)8-C(O)O-(CH2)1-, ##-(CH2)8-C(O)O-(CH2)2-, ##-CH2-O C(O)-CH2-、##-CH2-OC(O)-(CH2)2-、##-(CH2)1-OC(O)-(CH2)3-、##-(CH2)1-OC(O)-(CH2)4-、##-(CH2)1-OC(O)-(CH2)5-、##-(CH2 )1-OC(O)-(CH2)6-、##-(CH2)1-OC(O)-(CH2)7-、##-(CH2)1-OC(O)-(CH2)8-、##-(CH2)1-OC(O)-(CH2)9-、##-(CH2)1-OC(O)-(CH2) 10-、##-(CH2)2-OC(O)-(CH2)1-、##-(CH2)2-OC(O)-(CH2)2-、##-(CH2)2-OC(O)-(CH2)3-、##-(CH2)2-OC(O)-(CH2)4-、##-(CH2)2-OC(O)-(CH2)5-、##-(CH2)2-OC(O)-(CH2)6-、##-(CH2)2-OC(O)-(CH2)7-、##-(CH2)2-OC(O)-(CH2)8-、##-(CH2)2-OC(O)-(CH2)9-、##-(CH2)2-OC(O)-(CH2) 10 -、##-(CH2)2-OC(O)-(CH2) 11 -、##-(CH2)2-OC(O)-(CH2) 12 -、##-(CH2)3-OC(O)-(CH2)1-、##-(CH2)3-OC(O)-(CH2)2-、##-(CH2)3-OC(O)-(CH2)3-、##-(CH2)3-OC(O)-(CH2)4-、##-(CH2)3-OC(O)-(CH2)5-、##-(CH2)3-OC(O)-(CH2)6-、##-(CH2)3-OC(O)-(CH2)7-、##-(CH2)4-OC(O)-(CH2)1-、##-(CH2)4-OC(O)-(CH2)2-、##-(CH2)4-OC(O)-(CH2)3-、##-(CH2)4-OC(O)-(CH2)4-、##-(CH2)4-OC(O)-(CH2)5-、##-(CH2)4-OC(O)-(CH2)6-、##-(CH2)5-OC(O)-(CH2)1-、##-(CH2)5-OC(O)-(CH2)2-、##-(CH2)5-OC(O)-(CH2)3-、##-(CH2)5-OC(O)-(CH2)4-、##-(CH2)5-OC(O)-(CH2)5-、##-(CH2)6-OC(O)-(CH2)1-、##-(CH2)6-OC(O)-(CH2)2-、##-(CH2)6-OC(O)-(CH2)3-、##-(CH2)6-OC(O)-(CH2)4-、##-(CH2)7-OC(O)-(CH2)1-、##-(CH2)7-OC(O)-(CH2)2-、##-(CH2)7-OC(O)-(CH2)3-、##-(CH2)8-OC(O)-(CH2)1-、##-(CH2)8-OC(O)-(CH2)2-、##-(CH2)1-N(R g10)-(CH2)1-、##-(CH2)1-N(R g10 )-(CH2)2-、##-(CH2)1-N(R g10 )-(CH2)3-、##-(CH2)1-N(R g10 )-(CH2)4-、##-(CH2)1-N(R g10 )-(CH2)5-、##-(CH2)1-N(R g10 )-(CH2)6-、##-(CH2)1-N(R g10 )-(CH2)7-、##-(CH2)1-N(R g10 )-(CH2)8-、##-(CH2)1-N(R g10 )-(CH2)9-、##-(CH2)1-N(R g10 )-(CH2) 10 -、##-(CH2)2-N(R g10 )-(CH2)1-、##-(CH2)2-N(R g10 )-(CH2)2-、##-(CH2)2-N(R g10 )-(CH2)3-、##-(CH2)2-N(R g10 )-(CH2)4-、##-(CH2)2-N(R g10 )-(CH2)5-、##-(CH2)2-N(R g10 )-(CH2)6-、##-(CH2)2-N(R g10 )-(CH2)7-、##-(CH2)2-N(R g10 )-(CH2)8-、##-(CH2)2-N(R g10 )-(CH2)9-、##-(CH2)2-N(R g10 )-(CH2) 10 -、##-(CH2)2-N(R g10 )-(CH2) 11 -、##-(CH2)2-N(R g10 )-(CH2) 12 -、##-(CH2)3-N(R g10 )-(CH2)1-、##-(CH2)3-N(R g10 )-(CH2)2-、##-(CH2)3-N(R g10 )-(CH2)3-、##-(CH2)4-N(R g10 )-(CH2)1-、##-(CH2)4-N(R g10)-(CH2)2-、##-(CH2)4-N(R g10 )-(CH2)3-、##-(CH2)4-N(R g10 )-(CH2)4-、##-(CH2)5-N(R g10 )-(CH2)1-、##-(CH2)5-N(R g10 )-(CH2)2-、##-(CH2)5-N(R g10 )-(CH2)3-、##-(CH2)5-N(R g10 )-(CH2)4-、##-(CH2)5-N(R g10 )-(CH2)5-、##-(CH2)6-N(R g10 )-(CH2)1-、##-(CH2)6-N(R g10 )-(CH2)2-、##-(CH2)6-N(R g10 )-(CH2)3-、##-(CH2)7-N(R g10 )-(CH2)1-、##-(CH2)7-N(R g10 )-(CH2)2-、##-(CH2)7-N(R g10 )-(CH2)3-、##-(CH2)8-N(R g10 )-(CH2)1-、##-(CH2)8-NR g10 )-(CH2)2-、##-(CH2)8-N(R g10 )-(CH2)3-、##-CH(CH3)-N(R g10 )-(CH2)1-、##-CH(CH3)-N(R g10 )-(CH2)2-、##-CH(CH3)-N(R g10 )-(CH2)3-、##-CH(CH3)-N(R g10 )-(CH2)4-、##-CH(CH3)-N(R g10 )-(CH2)5-、##-CH(CH3)-N(R g10 )-(CH2)6-、##-CH(CH3)-N(R g10 )-(CH2)7-、##-CH(CH3)-N(R g10 )-(CH2)8-、##-CH(CH3)-N(R g10 )-(CH2)9-、##-CH(CH3)-N(R g10 )-(CH2) 10-##-CH2C(O)NHCH2-##-(CH2)2C(O)NH(CH2)2-##-(CH2)2C(O)NH(CH2)3-##-(CH2)2C(O)NH(CH2)4-##-(CH2)2C(O)NH(CH2)5-##-(CH2)3C(O)NH(CH2)3-##-(CH2)3C(O)NH(CH2)4-##-(C H2)4C(O)NH(CH2)4-,##-(CH2)5C(O)NH(CH2)5-,##-(CH2)6C(O)NH(CH2)7-,##-(CH2)6C(O)NH(CH2)6-,##-(CH2)7C(O)NH(CH2)7-,##-(CH2)8C(O)NH(CH2)8,##-(CH2)9C(O)NH(CH2)9-,##-(CH2) 10 C(O)NH(CH2) 10 -、##-(CH2)2C(O)NH(CH2)2-O-(CH2)2-、##-CH2NHC(O)CH2-、##-(CH2)2NHC(O)(CH2)2-、##-(CH2)2NHC(O) (CH2)3-、##-(CH2)2NHC(O)(CH2)4-、##-(CH2)2NHC(O)(CH2)5-、##-(CH2)3NHC(O)(CH2)3-、##-(CH2)3NHC (O)(CH2)4-、##-(CH2)4NHC(O)(CH2)4-、##-(CH2)5NHC(O)(CH2)5-、##-(CH2)6NHC(O)(CH2)7-、##-(CH2)6 NHC(O)(CH2)6-、##-(CH2)7NHC(O)(CH2)7-、##-(CH2)8NHC(O)(CH2)8、##-(CH2)9NHC(O)(CH2)9-、##-(CH2) 10 NHC(O)(CH2) 10-、##-(CH2)4NHC(O)(CH2)8-、##-(CH2)2NHC(O)(CH2)2-O-(CH2)2-、##-(CH2)4NHC(O)CH2-、##-CH2-piperidinyl-CH2-、##-CH2-piperidinyl-(CH2)2-、##-CH2-piperidinyl-(CH2)3-、##-CH2-piperidinyl-(CH2)4-、##-CH2-piperidinyl-(CH2)5-、##-CH2-piperidinyl-(CH2)6-、##-CH2-piperidinyl-(CH2)7-、##-CH2-piperidinyl-(CH2)8-、##-(CH2)2-piperidinyl- Pyridyl-(CH2)1-, ##-(CH2)2-piperidinyl-(CH2)2-, ##-(CH2)2-piperidinyl-(CH2)3-, ##-(CH2)2-piperidinyl-(CH2)4-, ##-(CH2)2-piperidinyl-(CH2)5-, ##-(CH2)2-piperidinyl-(CH2)6-, ##-(CH2)2-piperidinyl-(CH2)7-, ##-(CH2)2-piperidinyl-(CH2)8-, ##-(CH2)3-piperidinyl-CH2-, ##-(CH2)3-piperidinyl-(CH2)2-, ##-(CH2)3-piperidinyl-(CH2)3-, ##-(CH2)3 -piperidinyl-(CH2)4-, ##-(CH2)3-piperidinyl-(CH2)5-, ##-(CH2)3-piperidinyl-(CH2)6-, ##-(CH2)3-piperidinyl-(CH2)7-, ##-(CH2)3-piperidinyl-(CH2)8-, ##-(CH2)4-piperidinyl-CH2-, ##-(CH2)4-piperidinyl-(CH2)2-, ##-(CH2)4-piperidinyl-(CH2)3-, ##-(CH2)4-piperidinyl-(CH2)4-, ##-(CH2)4-piperidinyl-(CH2)5-, ##-(CH2)4-piperidinyl-(CH2)6-, ##-(CH2)4-piperidinyl-(CH2)6-, ##-(CH2)4-piperidinyl-(CH2)4-, ##-(CH2)4-piperidinyl-(CH2)5-, ##-(CH2)4-piperidinyl-(CH2)6 ... 2) 4-Piperidinyl-(CH2)7-, ##-(CH2)4-piperidinyl-(CH2)8-, ##-(CH2)5-piperidinyl-(CH2)1-, ##-(CH2)5-piperidinyl-(CH2)2-, ##-(CH2)5-piperidinyl-(CH2)3-, ##-(CH2)5-piperidinyl-(CH2)4-, ##-(CH2)5-piperidinyl-(CH2)5-, ##-(CH2)5-piperidinyl-(CH2)6-, ##-(CH2)5-piperidinyl-(CH2)7-, ##-(CH2)5-piperidinyl-(CH2)8-, ##-(CH2)6-piperidinyl-(CH2)1-,##-(CH2)6-piperidinyl-(CH2)2-, ##-(CH2)6-piperidinyl-(CH2)3-, ##-(CH2)6-piperidinyl-(CH2)4-, ##-(CH2)6-piperidinyl-(CH2)5-, ##-(CH2)6-piperidinyl-(CH2)6-, ##-(CH2)6-piperidinyl-(CH2)7-, ##-(CH2)6-piperidinyl-(CH2)8-, ##-(CH2)7-piperidinyl-(CH2)1-, ##-(CH2)7-piperidinyl-(CH2)2-, ##-(CH2)7-piperidinyl-(CH2)3-, ##-(CH2)7-piperidinyl-(CH2) )4-、##-(CH2)7-piperidinyl-(CH2)8-、##-(CH2)8-piperidinyl-CH2-、##-(CH2)8-piperidinyl-(CH2)2-、##-(CH2)8-piperidinyl-(CH2)3-、##-(CH2)8-piperidinyl-(CH2)4-、##-(CH2)8-piperidinyl-(CH2)5-、##-(CH2)8-piperidinyl-(CH2)6-、##-(CH2)8-piperidinyl-(CH2)7-、##-(CH2)8-piperidinyl-(CH2)8-、##-CH2-piperazinyl-CH2-、##-CH2-piperazinyl-(CH2)2-、##-CH 2-Piperazinyl-(CH2)3-, ##-CH2-piperazinyl-(CH2)4-, ##-CH2-piperazinyl-(CH2)5-, ##-CH2-piperazinyl-(CH2)6-, ##-CH2-piperazinyl-(CH2)7-, ##-CH2-piperazinyl-(CH2)8-, ##-(CH2)2-piperazinyl-(CH2)1-, ##-(CH2)2-piperazinyl-(CH2)2-, ##-(CH2)2-piperazinyl-(CH2)3-, ##-(CH2)2-piperazinyl-(CH2)4-, ##-(CH2)2-piperazinyl-(CH2)5-, ##-(CH2)2-piperazinyl-(CH2) 6-、##-(CH2)2-piperazinyl-(CH2)7-、##-(CH2)2-piperazinyl-(CH2)8-、##-(CH2)3-piperazinyl-CH2-、##-(CH2)3-piperazinyl-(CH2)2-、##-(CH2)3-piperazinyl-(CH2)3-、##-(CH2)3-piperazinyl-(CH2)4-、##-(CH2)3-piperazinyl-(CH2)5-、##-(CH2)3-piperazinyl-(CH2)6-、##-(CH2)3-piperazinyl-(CH2)7-、##-(CH2)3-piperazinyl-(CH2)8-、##-(CH2)4-piperazinyl-CH2-、##-(CH2)4-piperazinyl-(CH2)2-, ##-(CH2)4-piperazinyl-(CH2)3-, ##-(CH2)4-piperazinyl-(CH2)4-, ##-(CH2)4-piperazinyl-(CH2)5-, ##-(CH2)4-piperazinyl-(CH2)6-, ##-(CH2)4-piperazinyl-(CH2)7-, ##-(CH2)4-piperazinyl-(CH2)8-, ##-(CH2)5-piperazinyl-(CH2)1-, ##-(CH2)5-piperazinyl-(CH2)2-, ##-(CH2)5-piperazinyl-(CH2)3-, ##-(CH2)5-piperazinyl-(CH2) )4-、##-(CH2)5-piperazinyl-(CH2)5-、##-(CH2)5-piperazinyl-(CH2)6-、##-(CH2)5-piperazinyl-(CH2)7-、##-(CH2)5-piperazinyl-(CH2)8-、##-(CH2)6-piperazinyl-(CH2)1-、##-(CH2)6-piperazinyl-(CH2)2-、##-(CH2)6-piperazinyl-(CH2)3-、##-(CH2)6-piperazinyl-(CH2)4-、##-(CH2)6-piperazinyl-(CH2)5-、##-(CH2)6-piperazinyl-(CH2)6-、##-(CH2)6-piperazinyl- (CH2)7-, ##-(CH2)6-piperazinyl-(CH2)8-, ##-(CH2)7-piperazinyl-(CH2)1-, ##-(CH2)7-piperazinyl-(CH2)2-, ##-(CH2)7-piperazinyl-(CH2)3-, ##-(CH2)7-piperazinyl-(CH2)4-, ##-(CH2)7-piperazinyl-(CH2)8-, ##-(CH2)8-piperazinyl-CH2-, ##-(CH2)8-piperazinyl-(CH2)2-, ##-(CH2)8-piperazinyl-(CH2)3-, ##-(CH2)8-piperazinyl-(CH2)4-, ##-(CH2)8-piperazinyl -(CH2)5-, ##-(CH2)8-piperazinyl-(CH2)6-, ##-(CH2)8-piperazinyl-(CH2)7-, ##-(CH2)8-piperazinyl-(CH2)8-, ##-CH2-propylidene-CH2-, ##-CH2-propylidene-(CH2)2-, ##-CH2-propylidene-(CH2)3-, ##-CH2-propylidene-(CH2)4-, ##-CH2-propylidene-(CH2)5-, ##-CH2-propylidene-(CH2)6-, ##-CH2-propylidene-(CH2)7-, ##-CH2-propylidene-(CH2)8-, ##-(CH2)2-propylidene-(CH2)1-##-(CH2)2-propylidene-(CH2)2-, ##-(CH2)2-propylidene-(CH2)3-, ##-(CH2)2-propylidene-(CH2)4-, ##-(CH2)2-propylidene-(CH2)5-, ##-(CH2)2-propylidene-(CH2)6-, ##-(CH2)2-propylidene-(CH2)7-, ##-(CH2)2-propylidene-(CH2)8-, ##-(CH2)3-propylidene-CH2-, ##-(CH2)3-propylidene-(CH2)2-, ##-(CH2)3-propylidene-(CH2)3-, ##-(CH2)3-propylidene-(CH2)4-, ##-(CH 2) 3-Propylene-(CH2)5-, ##-(CH2)3-Propylene-(CH2)6-, ##-(CH2)3-Propylene-(CH2)7-, ##-(CH2)3-Propylene-(CH2)8-, ##-(CH2)4-Propylene-CH2-, ##-(CH2)4-Propylene-(CH2)2-, ##-(CH2)4-Propylene-(CH2)3-, ##-(CH2)4-Propylene-(CH2)4-, ##-(CH2)4-Propylene-(CH2)5-, ##-(CH2)4-Propylene-(CH2)6-, ##-(CH2)4-Propylene-(CH2)7-, ##-(CH2)4-Propylene propyl-(CH2)8-, ##-(CH2)5-propylidene-(CH2)1-, ##-(CH2)5-propylidene-(CH2)2-, ##-(CH2)5-propylidene-(CH2)3-, ##-(CH2)5-propylidene-(CH2)4-, ##-(CH2)5-propylidene-(CH2)5-, ##-(CH2)5-propylidene-(CH2)6-, ##-(CH2)5-propylidene-(CH2)7-, ##-(CH2)5-propylidene-(CH2)8-, ##-(CH2)6-propylidene-(CH2)1-, ##-(CH2)6-propylidene-(CH2)2-, ##-(CH2)6-propylidene-( CH2)3-, ##-(CH2)6-propylidene-(CH2)4-, ##-(CH2)6-propylidene-(CH2)5-, ##-(CH2)6-propylidene-(CH2)6-, ##-(CH2)6-propylidene-(CH2)7-, ##-(CH2)6-propylidene-(CH2)8-, ##-(CH2)7-propylidene-(CH2)1-, ##-(CH2)7-propylidene-(CH2)2-, ##-(CH2)7-propylidene-(CH2)3-, ##-(CH2)7-propylidene-(CH2)4-, ##-(CH2)7-propylidene-(CH2)8-, ##-(CH2)8-propylidene-CH2-,##-(CH2)8-Propylene-(CH2)2-, ##-(CH2)8-Propylene-(CH2)3-, ##-(CH2)8-Propylene-(CH2)4-, ##-(CH2)8-Propylene-(CH2)5-, ##-(CH2)8-Propylene-(CH2)6-, ##-(CH2)8-Propylene-(CH2)7-, ##-(CH2)8-Propylene-(CH2)8-, ##-CH2-Diazacycloheptane-CH2-, ##-CH2-Diazacycloheptane-(CH2)2-, ##-CH2-Diazacycloheptane-(CH2)3-, ##-CH2-Diazacycloheptane-(CH2)4- ##-CH2-diazacyclic heptanediyl-(CH2)5-, ##-CH2-diazacyclic heptanediyl-(CH2)6-, ##-CH2-diazacyclic heptanediyl-(CH2)7-, ##-CH2-diazacyclic heptanediyl-(CH2)8-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)1-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)2-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)3-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)4-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)5-, ##-(CH2)2-diazacyclic Heptane-(CH2)6-, ##-(CH2)2-diazacyclic heptane-(CH2)7-, ##-(CH2)2-diazacyclic heptane-(CH2)8-, ##-(CH2)3-diazacyclic heptane-CH2-, ##-(CH2)3-diazacyclic heptane-(CH2)2-, ##-(CH2)3-diazacyclic heptane-(CH2)3-, ##-(CH2)3-diazacyclic heptane-(CH2)4-, ##-(CH2)3-diazacyclic heptane-(CH2)5-, ##-(CH2)3-diazacyclic heptane-(CH2)6-, ##-(CH2)3-diazacyclic heptane-( CH2)7-, ##-(CH2)3-diazacyclic heptane-(CH2)8-, ##-(CH2)4-diazacyclic heptane-CH2-, ##-(CH2)4-diazacyclic heptane-(CH2)2-, ##-(CH2)4-diazacyclic heptane-(CH2)3-, ##-(CH2)4-diazacyclic heptane-(CH2)4-, ##-(CH2)4-diazacyclic heptane-(CH2)5-, ##-(CH2)4-diazacyclic heptane-(CH2)6-, ##-(CH2)4-diazacyclic heptane-(CH2)7-, ##-(CH2)4-diazacyclic heptane-(CH2)8-##-(CH2)5-diazacyclic heptanediyl-(CH2)1-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)2-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)3-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)4-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)5-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)6-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)7-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)8-, ##-(CH2)6-diazacyclic heptanediyl-(CH2)1-, ##-(CH2) 6-diazacyclic heptanediol-(CH2)2-, ##-(CH2)6-diazacyclic heptanediol-(CH2)3-, ##-(CH2)6-diazacyclic heptanediol-(CH2)4-, ##-(CH2)6-diazacyclic heptanediol-(CH2)5-, ##-(CH2)6-diazacyclic heptanediol-(CH2)6-, ##-(CH2)6-diazacyclic heptanediol-(CH2)7-, ##-(CH2)6-diazacyclic heptanediol-(CH2)8-, ##-(CH2)7-diazacyclic heptanediol-(CH2)1-, ##-(CH2)7-diazacyclic heptanediol-(CH2)2-, ##-(CH2)7-diazacyclic Heptane-(CH2)3-, ##-(CH2)7-diazacyclic heptane-(CH2)4-, ##-(CH2)7-diazacyclic heptane-(CH2)8-, ##-(CH2)8-diazacyclic heptane-CH2-, ##-(CH2)8-diazacyclic heptane-(CH2)2-, ##-(CH2)8-diazacyclic heptane-(CH2)3-, ##-(CH2)8-diazacyclic heptane-(CH2)4-, ##-(CH2)8-diazacyclic heptane-(CH2)5-, ##-(CH2)8-diazacyclic heptane-(CH2)6-, ##-(CH2)8-diazacyclic heptane-(CH2) 7-, ##-(CH2)8-diazacyclic heptanediyl-(CH2)8-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-CH2-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)2-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)3-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)4-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)5-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)6-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)7-,##-CH2-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-CH2-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)5-, # #-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-CH2-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)4-, ## -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)3-,##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(C H2)6-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)7- Diazabicyclo[2.2.1]heptanyl-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)4-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-CH2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-(CH2)2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-(CH2)3-, ##-(CH2)8-diazabicyclo[2. 2.1] Heptane-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)7-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)8-, ##-CH2-diazabicyclo[3.1.1] Heptane-CH2-, ##-CH2-diazabicyclo[3.1.1] Heptane-(CH2)2-, ##-CH2-diazabicyclo[3.1.1] Heptane-(CH2)3-,##-CH2-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)1-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[3. 1.1] Heptane-(CH2)3-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)4-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)5-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)6-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)7-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)8-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane-CH2-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane-CH2-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane Heptane-(CH2)2-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-C H2-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)8-,##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)1-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)7- 、##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)8-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)1-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)2-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)3-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)4-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)5-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)6 -、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)7-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)8-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)1-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)2-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)3-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)4-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2) 8-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-CH2-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)7-,##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-CH2-diazabicyclo[3.2.1]octane-CH2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)3-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)5-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)6-, ##-CH2-diazabicyclo[3.2.1]octane Octane-(CH2)7-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)2-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)3-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)2-diazabicyclo[3.2.1]octane-( CH2)6-、##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)3-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2) )5-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)6-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)4-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)2-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)3- ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)2 -、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)5-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)6-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2) 1-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)8-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)8-, ##-CH2-diazabicyclo[2.2.2]octane-CH2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)8-, ##-CH2-diazabicyclo[3.2.2]octane-CH2-, ##-CH2-diazabicyclo[3.2.2]octane-(CH2) ... Bicyclic [2.2.2]octane-(CH2)3-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)4-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)5-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)6-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)7-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)8-, ##-(CH2)2-diazabicyclic [2.2.2]octane-(CH2)1-, ##-(CH2)2-diazabicyclic [2.2.2]octane-(C H2)2-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)3-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)4-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)5-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)6-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)7-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)8-、##-(CH2)3-diazabicyclo[2.2.2]octane-CH2 -、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)2-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)3-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)4-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)5-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)6-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)7-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)8-、##-(CH2)4-diazabicyclo[2.2.2]octane-CH2-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)7-, ## -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)6-, # #-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)4-,##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.2]octane-CH2-, ##-(CH2)8-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)8-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)8-diazabicyclo[2.2. 2] Octane-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)7-, or ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)8-;

[0269] Wherein, the propylidene, the piperidinyl, the piperazine, the diazacycloheptane, the diazabicyclo[2.2.1]heptane, the diazabicyclo[3.1.1]heptane, the diazabicyclo[3.2.1]octane, and the diazabicyclo[2.2.2]octane are independently and optionally further selected from deuterium, optionally deuterated C 1-4 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents;

[0270] Each R g10 Independently represent H or C 1-3 Alkyl; and

[0271] The symbol ## indicates the connection point with group X1.

[0272] In some embodiments of the compound of formula (I-1), L1 represents the following groups:

[0273]

[0274] The symbol ## represents the connection point with group X1.

[0275] In some embodiments of the compound of formula (I-1), L1 represents the structure of the following formula: ##-C 1-30 alkylene-, wherein the C1-30 The hydrogen atoms of one or more alkylene groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) CH2 may optionally be further substituted by substituents selected from: D, optionally deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, C 1-6 Alkoxy groups or any combination thereof, and the symbol ## indicates the connection point with group X1. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0276] In some embodiments of the compound of formula (I-1), L1 represents the following groups:

[0277] ##-CH2-、##-(CH2)2-、##-(CH2)3-、##-(CH2)4-、##-(CH2)5-、##-(CH2)2-CF2-(CH2)2-、##-(CH2)6-、##-(CH2)7-、##-(CH2)8-、##-(CH2)9-、##-(CH2) 10 -、##-(CH2) 11 -、##-(CH2) 12 -、##-(CH2) 13 -、##-(CH2) 14 -、##-(CH2) 15 -、##-(CH2) 16 -、##-(CH2) 17 -、##-(CH2) 18 -、##-(CH2) 19 -、##-(CH2) 20 -、##-(CH2) 21 -、##-(CH2) 22 -、##-(CH2) 25 -、or ##-(CH2) 30 -;

[0278] The hydrogen atoms of one or more of the groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) of CH2 may optionally be further replaced by substituents selected from: D, optionally deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 Alkyl, optional deuterated C3-6 cycloalkyl, C 1-6 Alkoxy groups or any combination thereof, and the symbol ## indicates the connection point with group X1. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0279] In some embodiments of the compound of formula (I-1), R b This indicates C that is optionally substituted with D or halogen. 1-60 Alkyl (e.g., C1-C) 30 Alkyl, C1-C 29 Alkyl, C1-C 28 Alkyl, C1-C 27 Alkyl, C1-C 26 Alkyl, C1-C 25 Alkyl, C1-C 24 Alkyl, C1-C 23 Alkyl, C1-C 22 Alkyl, C1-C 21 Alkyl, C1-C 20 Alkyl, C1-C 19 Alkyl, C1-C 18 Alkyl, C1-C 17 Alkyl, C1-C 16 Alkyl, C1-C 15 Alkyl, C1-C 14 Alkyl, C1-C 13 Alkyl, C1-C 12 Alkyl, C1-C 11 Alkyl, C1-C 10 Alkyl, C1-C9 alkyl, C1-C8 alkyl, C1-C7 alkyl, C1-C6 alkyl, C1-C5 alkyl, C1-C4 alkyl, C1-C3 alkyl, or C1-C2 alkyl).

[0280] In some embodiments of the compound of formula (I-1), R b The following groups are represented: CH3, CF3, CD3, CH2CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2) 10 -CH3, -(CH2) 11 -CH3, -(CH2) 12 -CH3, -(CH2) 13 -CH3, -(CH2) 14 -CH3, -(CH2) 15-CH3, -(CH2) 16 -CH3, -(CH2) 17 -CH3, -(CH2) 18 -CH3, -(CH2) 19 -CH3, -(CH2) 20 -CH3, -(CH2) 21 -CH3, -(CH2) 22 -CH3, -(CH2) 23 -CH3, -(CH2) 24 -CH3, -(CH2) 25 -CH3, -(CH2) 26 -CH3, -(CH2) 27 -CH3, -(CH2) 28 -CH3, or -(CH2) 29 -CH3.

[0281] In some embodiments of the compound of formula (I-1), R b The following expression is represented:

[0282] R b1 -X4-L2-,

[0283] Where L2 represents:

[0284] Optionally, D or C can be selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1). 1-4 Alkyl, halogen, C 3-6 Substituents of the group consisting of cycloalkyl groups or any combination thereof, substituents of the straight or branched C-chain groups 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-

[0285] C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene

[0286] Or ethylene), or

[0287] One or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) groups R are inserted into its main carbon chain. 12 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 With R 13 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein the group R 12 R 13 Or group R 12 With R 13 Any combination thereof breaks one or more pairs (e.g., 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 14 Independently represent H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 12 At that time, each group R 12 They are not directly connected to each other; each group R 13 Selected independently from C 3-15 Cycloalkylene, 4- to 15-membered heterocyclic cycloalkylene, C 6-10 arylene, 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the 4- to 15-membered heterocyclic alkylene group, C 6-10 The arylene and the 5- to 15-membered heteroarylene are each optionally further modified by one or more (e.g., 1-20, or 1-15, 1-10, ...)

[0288] 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) are selected from D, optional deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl groups (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy groups (e.g., C) 1-3Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl groups -NHC(O)-, such as CH3-NHC(O)-, CH3CH2-

[0289] NHC(O)-, and CH3CH2CH2-NHC(O)-), C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-

[0290] Substituents such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), cyano groups or any combination thereof, and the C of the straight or branched chain. 2-60 Alkylenes may optionally be selected from one or more of D, C 1-4 Alkyl (e.g., C10) 1-3 Alkyl groups, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, halogens, C 3-6 Substituents of cycloalkyl groups or any combination thereof;

[0291] X4 represents a key or X4 represents N(R) 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optional substituted C 3-20 Cycloalkylene, optional substituted C 6-20 arylene, optionally substituted 4- to 20-membered heterocyclic arylene, optionally substituted 5- to 20-membered heterocyclic arylene, triazolyl-NH-, or -NH-triazolyl, wherein R 15 Indicates H or C 1-3 Alkyl groups, and the C3-20 Cycloalkylene, the C 6-20 The aryl group, the 4- to 20-membered heterocyclic group, and the 5- to 20-membered heterocyclic group are each independently and optionally selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) from D, halogen, or optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 alkyl-

[0292] NHC(O)- (e.g., C) 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and

[0293] CH3CH2CH2-NHC(O)-), C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, for example CH3-

[0294] Substituents of C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof, are substituted; and

[0295] R b1 C represents an optional substitution 3-20 cycloalkyl, optional substituted C 6-20 Aryl, optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 20-membered heteroaryl groups, wherein the C3-20 cycloalkyl, the C 6-20 The aryl group, the 4- to 20-membered heterocyclic group, and the 5- to 20-membered heteroaryl group are each optionally and independently further selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) from D, optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, with optional substituted C4 groups. 3-15 Cycloalkyl (e.g., optionally substituted cyclopropyl, optionally substituted cyclobutyl, optionally substituted cyclopentyl, or optionally substituted cyclohexyl), optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH-

[0296] (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 alkyl-

[0297] NHC(O)- (e.g., C) 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and

[0298] CH3CH2CH2-NHC(O)-), C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, for example CH3-

[0299] Substitution of C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally selected independently by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) selected from D, optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-

[0300] NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, for example CH3-NHC(O)-

[0301] CH3CH2-NHC(O)- and CH3CH2CH2-NHC(O)-), C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 alkyl-

[0302] C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof, are substituted. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0303] In some embodiments of the compound of formula (I-1), L2 represents the structure of the following formula: -C 2-30 alkylene-, wherein the C 2-30 The hydrogen atoms of one or more alkylene groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) CH2 may optionally be further substituted by substituents selected from: D, C 1-4 Alkyl, halogen, C 3-6 Cycloalkyl groups or any combination thereof.

[0304] In some embodiments of the compound of formula (I-1), L2 represents the following groups:

[0305] -CH2-, -(CH2)2-, -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)2-CF2-(CH2)2-, -(CH2)6-, -(CH2)7-, -

[0306] (CH2)8-, -(CH2)9-, -(CH2) 10 -、-(CH2) 11 -、-(CH2) 12 -、-(CH2) 13 -、-(CH2) 14 -、-(CH2) 15 -、-

[0307] (CH2) 16 -、-(CH2) 17 -、-(CH2) 18 -、-(CH2) 19 -、-(CH2) 20 -、-(CH2) 21 -、-(CH2) 22 -、-(CH2) 25 - or -(CH2) 30 -;

[0308] The hydrogen atoms of one or more of the groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) of CH2 may optionally be further replaced by substituents selected from: D, C 1-4 Alkyl, halogen, C 3-6 Cycloalkyl groups or any combination thereof.

[0309] In some embodiments of the compound of formula (I-1), L2 represents the structure of the following formula:

[0310] -(C(Ra9 )(R a10 )) m1 -(R 12 (C(R a11 )(R a12 )) m2 ) p1 -;

[0311] -(C(R a9 )(R a10 )) m1 -(R 12 (C(R a11 )(R a12 )) m2 ) p1 -(R 12 (C(R a13 )(R a14 )) m3 ) p2 -;

[0312] -(C(R a9 )(R a10 )) m1 -(R 12 (C(R a11 )(R a12 )) m2 ) p1 -(R 12 (C(R a13 )(R a14 )) m3 ) p2 -(R 12 (C(R a15 )(R a16 )) m4 ) p3 -;

[0313] -(C(R a9 )(R a10 )) m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -;

[0314] -(C(R a9 )(R a10 )) m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(Ra13 )(R a14 )) m3 ) p2 -;

[0315] -(C(R a9 )(R a10 )) m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(R a13 )(R a14 )) m3 ) p2 -(R 13 (C(R a15 )(R a16 )) m4 ) p3 -;

[0316] -(C(R a9 )(R a10 )) m1 -(R 12 -R 13 -(C(R a11 )(R a12 )) m2 ) p1 -;

[0317] -(C(R a9 )(R a10 )) m1 -(R 12 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(R a13 )(R a14 )) m3 ) p2 -;

[0318] -(C(R a9 )(R a10 )) m1 -(R 13 -R 12 -(C(R a11 )(R a12 )) m2 ) p1 -; or

[0319] -(C(R a9 )(Ra10 )) m1 -(R 13 (C(R a11 (R) a12 )) m2 ) p1 -(R 12 (C(R a13 (R) a14 )) m3 ) p2 -;

[0320] Among them, each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where each R 14 Independently represent H or C 1-3 Alkyl groups; R groups 13 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), halogenated C 1-4 Alkyl groups (e.g., halogenated C) 1-3Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof, are substituted with substituents;

[0321] R a9 R a10 R a11 R a12 R a13 R a14 R a15 and R a16 Each of the following can be represented independently: H, deuterium, halogen, and C. 1-4 Alkyl, C 3-6 cycloalkyl groups or any combination thereof; and

[0322] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0323] In some embodiments of the compound of formula (I-1), L2 represents the structure of the following formula:

[0324] -(C(R a9 (R) a10 )) m1 -(O(C(R a11 (R) a12 )) m2 ) p1 -;

[0325] -(C(R a9 (R) a10 )) m1 -(O(C(R a11 (R) a12 )) m2) p1 -(O(C(R a13 )(R a14 )) m3 ) p2 -;

[0326] -(C(R a9 )(R a10 )) m1 -(O(C(R a11 )(R a12 )) m2 ) p1 -(O(C(R a13 )(R a14 )) m3 ) p2 -(O(C(R a15 )(R a16 )) m4 ) p3 -;

[0327] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -;

[0328] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -(N(R g11 )(C(R a13 )(R a14 )) m3 ) p2 -;

[0329] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -(N(R g11 )(C(R a13 )(R a14 )) m3 ) p2 -

[0330] (N(R g11 )(C(R a15 )(R a16 )) m4 ) p3 -;

[0331] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -;

[0332] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(C(O)NH-(C(R a13 )(R a14 )) m3 ) p2 -;

[0333] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(C(O)NH-(C(R a13 )(R a14 )) m3 ) p2 -(C(O)NH-(C(R a15 )(R a16 )) m4 ) p3 -;

[0334] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -;

[0335] -(C(Ra9 )(R a10 )) m1 -C(O)NH-(C(R a11 )(R a12 )) m2 -(O(C(R a13 )(R a14 )) m3 ) p1 -;

[0336] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1 -;

[0337] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -;

[0338] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -(O-(C(R a15 )(R a16 )) m4 ) p3 -;

[0339] -(C(R a9 )(R a10 )) m1 -NHC(O)-(C(R a11 )(R a12 )) m2 -(O(C(R a13 )(R a14 )) m3 ) p1-;

[0340] -(C(R a9 (R) a10 )) m1 -NHC(O)NH-(C(R a11 (R) a12 )) m2 -;

[0341] -(C(R a9 (R) a10 )) m1 -C(O)-(C(R a11 (R) a12 )) m2 -;

[0342] -(C(R a9 (R) a10 )) m1 -C(S)-(C(R a11 (R) a12 )) m2 -;

[0343] -(C(R a9 (R) a10 )) m1 -S-(C(R a11 (R) a12 )) m2 -;

[0344] -(C(R a9 (R) a10 )) m1 -(C 6-10 Aspartic-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0345] -(C(R a9 (R) a10 )) m1 -(C 6-10 Aspartic-(C(R) a11 (R) a12 )) m2 ) p1 -C 6-10 Aspartic-(C(R) a13 (R) a14 )) m3 -;

[0346] -(C(R a9 (R) a10 )) m1-(4-to-15-membered heterocyclic group-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0347] -(C(R a9 (R) a10 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a11 (R) a12 )) m2 ) p1 -(4-to-15-membered heterocyclic group-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0348] -(C(R a9 (R) a10 )) m1 -(5-to-15-methylheteroaryl-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0349] -(C(R a9 (R) a10 )) m1 -(5-to-15-methylheteroaryl-(C(R) a11 (R) a12 )) m2 ) p1 -(5-to-15-methylheteroaryl-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0350] -(C(R a9 (R) a10 )) m1 -(C 3-15 Cycloalkylene-(C(R) a11 (R) a12 )) m2 ) p1 -;or

[0351] -(C(R a9 (R) a10 )) m1 -(C 3-15 Cycloalkylene-(C(R) a11 (R) a12 )) m2 )p1 -(C 3-15 Cycloalkylene-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0352] Among them, each R g11 Independently represent H or C 1-3 alkyl;

[0353] The C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-4 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents;

[0354] R a9 R a10 R a11 R a12 R a13 R a14 R a15 and R a16 Each of the following can be represented independently: H, deuterium, halogen, and C. 1-4 Alkyl, C 3-6 cycloalkyl groups or any combination thereof; and

[0355] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0356] In some embodiments of the compound of formula (I-1), L2 represents the structure of the following formula:

[0357] -CH2-O-CH2-,-CH2-O-(CH2)2-,-(CH2)1-O-(CH2)3-,-(CH2)1-O-(CH2)4-,-(CH2)1-O-(CH2)5-,-(CH2)1-O-(CH2)6-,-(CH2)1-O-(CH2)7-,-(CH2)1-O-(CH2)8-,-(CH2)1-O-(CH2)9-,-(CH2)1-O-(CH2) 10 -、-(CH2)2-O-(CH2)1-、-(CH2)2-O-(CH2)2-、-(CH2)2-O-(CH2)3-、-(CH2)2-O-(CH2)4-、-(CH2)2-O-(CH2)5-、-(CH2)2-O-(CH2)6-、-(CH2)2-O-(CH2)7-、-(CH2)2-O-(CH2)8-、-(CH2)2-O-(CH2)9-、-(CH2)2-O-(CH2) 10 -、-(CH2)2-O-(CH2) 11 -、-(CH2)2-O-(CH2) 12-、-(CH2)3-O-(CH2)1-、-(CH2)3-O-(CH2)2-、-(CH2)3-O-(CH2)3-、-(CH2)3-O-(CH2)4-、-(CH2)3-O-(CH2)5-、-(CH2)3-O-(CH2)6-、-(CH2)3-O-(CH2)7-、-(CH2)4-O-(CH2)1-、-(CH2)4-O-(CH2)2-、-(CH 2)4-O-(CH2)3-,-(CH2)4-O-(CH2)4-,-(CH2)4-O-(CH2)5-,-(CH2)4-O-(CH2)6-,-(CH2)5-O-(CH2)1-,-(CH2)5-O-(CH2)2-,-(CH2)5-O-(CH2)3-,-(CH2)5-O-(CH2)4-,-(CH2)5-O-(CH2)5-,-(CH2)6-O-( CH2)1-、-(CH2)6-O-(CH2)2-、-(CH2)6-O-(CH2)3-、-(CH2)6-O-(CH2)4-、-(CH2)7-O-(CH2)1-、-(CH2)7-O-(CH2)2-、-(CH2)7-O-(CH2)3-、-(CH2)8-O-(CH2)1-、-(CH2)8-O-(CH2)2-、-CH(CH3)-O-(CH2)1- -CH(CH3)-O-(CH2)2-, -CH(CH3)-O-(CH2)3-, -CH(CH3)-O-(CH2)4-, -CH(CH3)-O-(CH2)5-, -CH(CH3)-O-(CH2)6-, -CH(CH3)-O-(CH2)7-, -CH(CH3)-O-(CH2)8-, -CH(CH3)-O-(CH2)9-, -CH(CH3)-O-(CH2) 10 -CH2-(O(CH2)2)2- -CH2-(O(CH2)2)3- -CH2-(O(CH2)2)4- -CH2-(O(CH2)2)5- -CH2-(O(CH2)2)6- -CH2-(O(CH2)2)7- -CH2-(O(CH2)2)8- -CH2-(O(CH2)2)9- -CH2-(O(CH2)2) 10-、-CH2-(O(CH2)2)1-OCH2-、-CH2-(O(CH2)2)2-OCH2-、-CH2-(O(CH2)2)3-OCH2-、-CH2-(O(CH2)2)4-OCH2-、-CH2-(O(CH2)2)5-OCH2-、-CH2-(O(CH2)2)6-OCH2-、-CH2-(O(CH2)2)7-OCH2-、-CH2-(O(CH2)2)8-OCH2-、-CH2-(O(CH2)2)9-OCH2-、-CH2-(O(CH2)2) 10 -OCH2-、-(CH2)2-(O(CH2)2)2-、-(CH2)2-(O(CH2)2)3-、-(CH2)2-(O(CH2)2)4-、-(CH2)2-(O(CH2)2)5-、-(CH2)2-(O(CH2)2)6-、-(CH2)2-(O(CH2)2)7-、-(CH2)2-(O(CH2)2)8-、-(CH2)2-(O(CH2)2)9-、-(CH2)2-(O(CH2)2) 10 -、-(CH2)3-(O(CH2)2)2-、-(CH2)3-(O(CH2)2)3-、-(CH2)3-(O(CH2)2)4-、-(CH2)3-(O(CH2)2)5-、-(CH2)3-(O(CH2)2)6-、-(CH2)3-(O(CH2)2)7-、-(CH2)3-(O(CH2)2)8-、-(CH2)3-(O(CH2)2)9-、-(CH2)3-(O(CH2)2) 10 -、-(CH2)4-(O(CH2)2)2-、-(CH2)4-(O(CH2)2)3-、-(CH2)4-(O(CH2)2)4-、-(CH2)4-(O(CH2)2)5-、-(CH2)4-(O(CH2)2)6-、-(CH2)4-(O(CH2)2)7-、-(CH2)4-(O(CH2)2)8-、-(CH2)4-(O(CH2)2)9-、-(CH2)4-(O(CH2)2) 10 -、-CH2-(O(CH2)3)2-、-CH2-(O(CH2)3)3-、-CH2-(O(CH2)3)4-、-CH2-(O(CH2)3)5-、-CH2-(O(CH2)3)6-、-CH2-(O(CH2)3)7-、-CH2-(O(CH2)3)8-、-CH2-(O(CH2)3)9-、-CH2-(O(CH2)3) 10-、-(CH2)2-(O(CH2)3)2-、-(CH2)2-(O(CH2)3)3-、-(CH2)2-(O(CH2)3)4-、-(CH2)2-(O(CH2)3)5-、-(CH2)2-(O(CH2)3)6-、-(CH2)2-(O(CH2)3)7-、-(CH2)2-(O(CH2)3)8-、-(CH2)2-(O(CH2)3)9-、-(CH2)2-(O(CH2)3) 10 -、-(CH2)3-(O(CH2)3)2-、-(CH2)3-(O(CH2)3)3-、-(CH2)3-(O(CH2)3)4-、-(CH2)3-(O(CH2)3)5-、-(CH2)3-(O(CH2)3)6-、-(CH2)3-(O(CH2)3)7-、-(CH2)3-(O(CH2)3)8-、-(CH2)3-(O(CH2)3)9-、-(CH2)3-(O(CH2)3) 10-、-CH2-O-(CH2)2-O-(CH2)3-、-CH2-(O(CH2)2)2-(O(CH2)3)2-、-CH2-(O(CH2)2)3-(O(CH2)3)3-、-CH2-(O(CH2)2)4-(O(CH2)3)4-、-CH2-(O(CH2)2)5-(O(CH2)3)5-、-CH2-(O(CH2)2)6-(O(CH2)3)6-、-(CH2)2-O-(CH2)2-O-(CH2)3-、-(CH2)2-(O(CH2)2)2-(O(CH2)3)2-、-(CH2)2-(O(CH2)2)3-(O(CH2 )3)3-、-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-、-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-、-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-、-(CH2)3-O-(CH2)2-O-(CH2)3-、-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-、-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-、-(CH2)3-(O(CH2)2)4-(O(CH2)3)4-、-(CH2)3-(O(CH2)2)5-(O(CH2)3)5- 、-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-、-CH2-O-(CH2)3-O-(CH2)2-、-CH2-(O(CH2)3)2-(O(CH2)2)2-、-CH2-(O(CH2)3)3-(O(CH2)2)3-、-CH2-(O(CH2)3)4-(O(CH2)2)4-、-CH2-(O(CH2)3)5-(O(CH2)2)5-、-CH2-(O(CH2)3)6-(O(CH2)2)6-、-(CH2)2-O-(CH2)3-O-(CH2)2-、-(CH2)2-(O(CH2)3)2-(O(CH2) 2)2-、-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-、-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-、-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-、-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-、-(CH2)3-O-(CH2)3-O-(CH2)2-、-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-、-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-、-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-、-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-、-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-、-CH2-O-(CH2)2-O-CH2-、-(CH2)2-O-(CH2)2-O-CH2-、-(CH2)2-(O(CH2)2)2-O-(CH2)3-、-(CH2)2-(O(CH2)2)3-O-(CH2)3-、-(CH2)2-(O(CH2)2)4-O-(CH2)3-、-(CH2)5-(O(CH2)2)2-O-(CH2)5-、-( CH2)5-(O(CH2)2)2-O-(CH2)6-、-CH2-C(O)-CH2-、-CH2-C(O)-(CH2)2-、-(CH2)1-C(O)-(CH2)3-、-(CH2)1-C(O)-(CH2)4-、-(CH2)1-C(O)-(CH2)5-、-(CH2)1-C(O)-(CH2)6-、-(CH2)1-C(O)-(CH2)7-、-(CH2)1-C(O)-(CH2)8-、-(CH2)1-C(O)-(CH2)9-、-(CH2)1-C(O)-(CH2)、 10 -、-(CH2)2-C(O)-(CH2)1-、-(CH2)2-C(O)-(CH2)2-、-(CH2)2-C(O)-(CH2)3-、-(CH2)2-C(O)-(CH2)4-、-(CH2)2-C(O)-(CH2)5-、-(CH2)2-C(O)-(CH2)6-、-(CH2)2-C(O)-(CH2)7-、-(CH2)2-C(O)-(CH2)8-、-(CH2)2-C(O)-(CH2)9-、-(CH2)2-C(O)-(CH2) 10 -、-(CH2)2-C(O)-(CH2) 11 -、-(CH2)2-C(O)-(CH2) 12-、-(CH2)3-C(O)-(CH2)1-、-(CH2)3-C(O)-(CH2)2-、-(CH2)3-C(O)-(CH2)3-、-(CH2)3-C(O)-(CH2)4-、-(CH2)3-C(O)-(CH2)5-、-(CH2)3-C(O)-(CH2)6-、-(CH2)3-C(O)-(CH2)7-、-(CH2)4-C(O)-(CH2)1-、-(CH2)4-C(O)-(CH2)2-、-(CH2)4-C(O)-(CH2)3-、-(CH2)4-C(O)-(CH2)4-、-(CH2)4-C(O)-(CH2)5-、-(CH2)4-C(O)-(CH2)6-、-(CH2)5-C(O)-(CH2)1-、-(CH2)5-C(O)-(CH2)2-、-(CH2)5-C(O)-(CH2)3-、-(CH2)5-C(O)-(CH2)4-、-(CH2)5-C(O)-(CH2)5-、-(CH2)6-C(O)-(CH2)1-、-(CH2)6-C(O)-(CH2)2-、-(CH2)6-C(O)-(CH2)3-、-(CH2)6-C(O)-(CH2)4-、-(CH2)7-C(O)-(CH2)1-、-(CH2)7-C(O)-(CH2)2-、-(CH2)7-C(O)-(CH2)3-、-(CH2)8-C(O)-(CH2)1-、-(CH2)8-C(O)-(CH2)2-、-CH2-S-CH2-、-CH2-S-(CH2)2-、-(CH2)1-S-(CH2)3-、-(CH2)1-S-(CH2)4-、-(CH2)1-S-(CH2)5-、-(CH2)1-S-(CH2)6-、-(CH2)1-S-(CH2)7-、-(CH2)1-S-(CH2)8-、-(CH2)1-S-(CH2)9-、-(CH2)1-S-(CH2) 10 -、-(CH2)2-S-(CH2)1-、-(CH2)2-S-(CH2)2-、-(CH2)2-S-(CH2)3-、-(CH2)2-S-(CH2)4-、-(CH2)2-S-(CH2)5-、-(CH2)2-S-(CH2)6-、-(CH2)2-S-(CH2)7-、-(CH2)2-S-(CH2)8-、-(CH2)2-S-(CH2)9-、-(CH2)2-S-(CH2) 10 -、-(CH2)2-S-(CH2) 11 -、-(CH2)2-S-(CH2) 12-、-(CH2)3-S-(CH2)1-、-(CH2)3-S-(CH2)2-、-(CH2)3-S-(CH2)3-、-(CH2)3-S-(CH2)4-、-(CH2)3-S-(CH2)5-、-(CH2)3-S-(CH2)6-、-(CH2)3-S-(CH2)7-、-(CH2)4-S-(CH2)1-、-(CH2)4-S-(CH2)2-、-(CH2)4-S-(CH2)3-、-(CH2)4-S-(CH2)4-、-(CH2)4-S-(CH2)5-、-(CH2)4-S-(CH2)6-、-(CH2)5-S-(CH2)1-、-(CH2)5-S-(CH2)2-、-(CH2)5-S-(CH2)3-、-(CH2)5-S-(CH2)4-、-(CH2)5-S-(CH2)5-、-(CH2)6-S-(CH2)1-、-(CH2)6-S-(CH2)2-、-(CH2)6-S-(CH2)3-、-(CH2)6-S-(CH2)4-、-(CH2)7-S-(CH2)1-、-(CH2)7-S-(CH2)2-、-(CH2)7-S-(CH2)3-、-(CH2)8-S-(CH2)1-、-(CH2)8-S-(CH2)2-、-CH2-C(S)-CH2-、-CH2-C(S)-(CH2)2-、-(CH2)1-C(S)-(CH2)3-、-(CH2)1-C(S)-(CH2)4-、-(CH2)1-C(S)-(CH2)5-、-(CH2)1-C(S)-(CH2)6-、-(CH2)1-C(S)-(CH2)7-、-(CH2)1-C(S)-(CH2)8-、-(CH2)1-C(S)-(CH2)9-、-(CH2)1-C(S)-(CH2) 10 -、-(CH2)2-C(S)-(CH2)1-、-(CH2)2-C(S)-(CH2)2-、-(CH2)2-C(S)-(CH2)3-、-(CH2)2-C(S)-(CH2)4-、-(CH2)2-C(S)-(CH2)5-、-(CH2)2-C(S)-(CH2)6-、-(CH2)2-C(S)-(CH2)7-、-(CH2)2-C(S)-(CH2)8-、-(CH2)2-C(S)-(CH2)9-、-(CH2)2-C(S)-(CH2) 10 -、-(CH2)2-C(S)-(CH2) 11 -、-(CH2)2-C(S)-(CH2) 12-、-(CH2)3-C(S)-(CH2)1-、-(CH2)3-C(S)-(CH2)2-、-(CH2)3-C(S)-(CH2)3-、-(CH2)3-C(S)-(CH2)4-、-(CH2)3-C(S)-(CH2)5-、-(CH2)3-C(S)-(CH2)6-、-(CH2)3-C(S)-(CH2)7-、-(CH2)4-C(S)-(CH2)1-、-(CH2)4-C(S)-(CH2)2-、-(CH2)4-C(S)-(CH2)3-、-(CH2)4-C(S)-(CH2)4-、-(CH2)4-C(S)-(CH2)5-、-(CH2)4-C(S)-(CH2)6-、-(CH2)5-C(S)-(CH2)1-、-(CH2)5-C(S)-(CH2)2-、-(CH2)5-C(S)-(CH2)3-、-(CH2)5-C(S)-(CH2)4-、-(CH2)5-C(S)-(CH2)5-、-(CH2)6-C(S)-(CH2)1-、-(CH2)6-C(S)-(CH2)2-、-(CH2)6-C(S)-(CH2)3-、-(CH2)6-C(S)-(CH2)4-、-(CH2)7-C(S)-(CH2)1-、-(CH2)7-C(S)-(CH2)2-、-(CH2)7-C(S)-(CH2)3-、-(CH2)8-C(S)-(CH2)1-、-(CH2)8-C(S)-(CH2)2-、-CH2-C(O)O-CH2-、-CH2-C(O)O-(CH2)2-、-(CH2)1-C(O)O-(CH2)3-、-(CH2)1-C(O)O-(CH2)4-、-(CH2)1-C(O)O-(CH2)5-、-(CH2)1-C(O)O-(CH2)6-、-(CH2)1-C(O)O-(CH2)7-、-(CH2)1-C(O)O-(CH2)8-、-(CH2)1-C(O)O-(CH2)9-、-(CH2)1-C(O)O-(CH2) 10-、-(CH2)2-C(O)O-(CH2)1-、-(CH2)2-C(O)O-(CH2)2-、-(CH2)2-C(O)O-(CH2)3-、-(CH2)2-C(O)O-(CH2)4-、-(CH2)2-C(O)O-(CH2)5-、-(CH2)2-C(O)O-(CH2)6-、-(CH2)2-C(O)O-(CH2)7-、-(CH2)2-C(O)O-(CH2)8-、-(CH2)2-C(O)O-(CH2)9-、-(CH2)2-C(O)O-(CH2) 10 -、-(CH2)2-C(O)O-(CH2) 11 -、-(CH2)2-C(O)O-(CH2) 12-、-(CH2)3-C(O)O-(CH2)1-、-(CH2)3-C(O)O-(CH2)2-、-(CH2)3-C(O)O-(CH2)3-、-(CH2)3-C(O)O-(CH2)4-、-(CH2)3-C(O)O-(CH2)5-、-(CH2)3-C(O)O-(CH2)6-、-(CH2)3-C(O)O-(CH2)7-、-(CH2)4-C(O)O-(CH2)1-、-(CH2)4-C(O)O-(CH2)2-、- (CH2)4-C(O)O-(CH2)3-、-(CH2)4-C(O)O-(CH2)4-、-(CH2)4-C(O)O-(CH2)5-、-(CH2)4-C(O)O-(CH2)6-、-(CH2)5-C(O)O-(CH2)1-、-(CH2)5-C(O)O-(CH2)2-、-(CH2)5-C(O)O-(CH2)3-、-(CH2)5-C(O)O-(CH2)4-、-(CH2)5-C(O)O-(CH2)5-、-(CH 2)6-C(O)O-(CH2)1-,-(CH2)6-C(O)O-(CH2)2-,-(CH2)6-C(O)O-(CH2)3-,-(CH2)6-C(O)O-(CH2)4-,-(CH2)7-C(O)O-(CH2)1-,-(CH2)7-C(O)O-(CH2)2-,-(CH2)7-C(O)O-(CH2)3-,-(CH2)8-C(O)O-(CH2)1-,-(CH2)8-C(O)O-(CH2)2-,-CH2-OC (O)-CH2-、-CH2-OC(O)-(CH2)2-、-(CH2)1-OC(O)-(CH2)3-、-(CH2)1-OC(O)-(CH2)4-、-(CH2)1-OC(O)-(CH2)5-、-(CH2) 1-OC(O)-(CH2)6-、-(CH2)1-OC(O)-(CH2)7-、-(CH2)1-OC(O)-(CH2)8-、-(CH2)1-OC(O)-(CH2)9-、-(CH2)1-OC(O)-(CH2) 10-、-(CH2)2-OC(O)-(CH2)1-、-(CH2)2-OC(O)-(CH2)2-、-(CH2)2-OC(O)-(CH2)3-、-(CH2)2-OC(O)-(CH2)4-、-(CH2)2-OC(O)-(CH2)5-、-(CH2)2-OC(O)-(CH2)6-、-(CH2)2-OC(O)-(CH2)7-、-(CH2)2-OC(O)-(CH2)8-、-(CH2)2-OC(O)-(CH2)9-、-(CH2)2-OC(O)-(CH2) 10 -、-(CH2)2-OC(O)-(CH2) 11 -、-(CH2)2-OC(O)-(CH2) 12 -、-(CH2)3-OC(O)-(CH2)1-、-(CH2)3-OC(O)-(CH2)2-、-(CH2)3-OC(O)-(CH2)3-、-(CH2)3-OC(O)-(CH2)4-、-(CH2)3-OC(O)-(CH2)5-、-(CH2)3-OC(O)-(CH2)6-、-(CH2)3-OC(O)-(CH2)7-、-(CH2)4-OC(O)-(CH2)1-、-(CH2)4-OC(O)-(CH2)2-、-(CH2)4-OC(O)-(CH2)3-、-(CH2)4-OC(O)-(CH2)4-、-(CH2)4-OC(O)-(CH2)5-、-(CH2)4-OC(O)-(CH2)6-、-(CH2)5-OC(O)-(CH2)1-、-(CH2)5-OC(O)-(CH2)2-、-(CH2)5-OC(O)-(CH2)3-、-(CH2)5-OC(O)-(CH2)4-、-(CH2)5-OC(O)-(CH2)5-、-(CH2)6-OC(O)-(CH2)1-、-(CH2)6-OC(O)-(CH2)2-、-(CH2)6-OC(O)-(CH2)3-、-(CH2)6-OC(O)-(CH2)4-、-(CH2)7-OC(O)-(CH2)1-、-(CH2)7-OC(O)-(CH2)2-、-(CH2)7-OC(O)-(CH2)3-、-(CH2)8-OC(O)-(CH2)1-、-(CH2)8-OC(O)-(CH2)2-、-(CH2)1-N(R g11 )-(CH2)1-、-(CH2)1-N(R g11 )-(CH2)2-、-(CH2)1-N(R g11)-(CH2)3-、-(CH2)1-N(R g11 )-(CH2)4-、-(CH2)1-N(R g11 )-(CH2)5-、-(CH2)1-N(R g11 )-(CH2)6-、-(CH2)1-N(R g11 )-(CH2)7-、-(CH2)1-N(R g11 )-(CH2)8-、-(CH2)1-N(R g11 )-(CH2)9-、-(CH2)1-N(R g11 )-(CH2) 10 -、-(CH2)2-N(R g11 )-(CH2)1-、-(CH2)2-N(R g11 )-(CH2)2-、-(CH2)2-N(R g11 )-(CH2)3-、-(CH2)2-N(R g11 )-(CH2)4-、-(CH2)2-N(R g11 )-(CH2)5-、-(CH2)2-N(R g11 )-(CH2)6-、-(CH2)2-N(R g11 )-(CH2)7-、-(CH2)2-N(R g11 )-(CH2)8-、-(CH2)2-N(R g11 )-(CH2)9-、-(CH2)2-N(R g11 )-(CH2) 10 -、-(CH2)2-N(R g11 )-(CH2) 11 -、-(CH2)2-N(R g11 )-(CH2) 12 -、-(CH2)3-N(R g11 )-(CH2)1-、-(CH2)3-N(R g11 )-(CH2)2-、-(CH2)3-N(R g11 )-(CH2)3-、-(CH2)4-N(R g11 )-(CH2)1-、-(CH2)4-N(R g11 )-(CH2)2-、-(CH2)4-N(R g11 )-(CH2)3-、-(CH2)4-N(R g11 )-(CH2)4-、-(CH2)5-N(R g11 )-(CH2)1-、-(CH2)5-N(R g11)-(CH2)2-、-(CH2)5-N(R g11 )-(CH2)3-、-(CH2)5-N(R g11 )-(CH2)4-、-(CH2)5-N(R g11 )-(CH2)5-、-(CH2)6-N(R g11 )-(CH2)1-、-(CH2)6-N(R g11 )-(CH2)2-、-(CH2)6-N(R g11 )-(CH2)3-、-(CH2)7-N(R g11 )-(CH2)1-、-(CH2)7-N(R g11 )-(CH2)2-、-(CH2)7-N(R g11 )-(CH2)3-、-(CH2)8-N(R g11 )-(CH2)1-、-(CH2)8-NR g11 )-(CH2)2-、-(CH2)8-N(R g11 )-(CH2)3-、-CH(CH3)-N(R g11 )-(CH2)1-、-CH(CH3)-N(R g11 )-(CH2)2-、-CH(CH3)-N(R g11 )-(CH2)3-、-CH(CH3)-N(R g11 )-(CH2)4-、-CH(CH3)-N(R g11 )-(CH2)5-、-CH(CH3)-N(R g11 )-(CH2)6-、-CH(CH3)-N(R g11 )-(CH2)7-、-CH(CH3)-N(R g11 )-(CH2)8-、-CH(CH3)-N(R g11 )-(CH2)9-、-CH(CH3)-N(R g11 )-(CH2) 10-、-CH2C(O)NHCH2-、-(CH2)2C(O)NH(CH2)2-、-(CH2)2C(O)NH(CH2)3-、-(CH2)2C(O)NH(CH2)4-、-(CH2)2C(O)NH(CH2)5-、-(CH2)3C(O)NH(CH2)3-、-(CH2)3C(O)NH(CH2)4-、-(CH 2)4C(O)NH(CH2)4-,-(CH2)5C(O)NH(CH2)5-,-(CH2)6C(O)NH(CH2)7-,-(CH2)6C(O)NH(CH2)6-,-(CH2)7C(O)NH(CH2)7-,-(CH2)8C(O)NH(CH2)8,-(CH2)9C(O)NH(CH2)9-,-(CH2) 10 C(O)NH(CH2) 10 -、-(CH2)2C(O)NH(CH2)2-O-(CH2)2-、-CH2NHC(O)CH2-、-(CH2)2NHC(O)(CH2)2-、-(CH2)2NHC(O) (CH2)3-、-(CH2)2NHC(O)(CH2)4-、-(CH2)2NHC(O)(CH2)5-、-(CH2)3NHC(O)(CH2)3-、-(CH2)3NHC (O)(CH2)4-、-(CH2)4NHC(O)(CH2)4-、-(CH2)5NHC(O)(CH2)5-、-(CH2)6NHC(O)(CH2)7-、-(CH2)6 NHC(O)(CH2)6-、-(CH2)7NHC(O)(CH2)7-、-(CH2)8NHC(O)(CH2)8、-(CH2)9NHC(O)(CH2)9-、-(CH2) 10 NHC(O)(CH2) 10-、-(CH2)4NHC(O)(CH2)8-、-(CH2)2NHC(O)(CH2)2-O-(CH2)2-、-(CH2)4NHC(O)CH2-、-CH2-piperidinyl-CH2-、-CH2-piperidinyl-(CH2)2-、-CH2-piperidinyl-(CH2)3-、-CH2-piperidinyl-(CH2)4-、-CH2-piperidinyl-(CH2)5-、-CH2-piperidinyl-(CH2)6-、-CH2-piperidinyl-(CH2)7-、-CH2-piperidinyl-(CH2)8-、-(CH2)2-piperidinyl-(CH2)1-、-(CH2)2-piperidinyl -(CH2)2-, -(CH2)2-piperidinyl-(CH2)3-, -(CH2)2-piperidinyl-(CH2)4-, -(CH2)2-piperidinyl-(CH2)5-, -(CH2)2-piperidinyl-(CH2)6-, -(CH2)2-piperidinyl-(CH2)7-, -(CH2)2-piperidinyl-(CH2)8-, -(CH2)3-piperidinyl-CH2-, -(CH2)3-piperidinyl-(CH2)2-, -(CH2)3-piperidinyl-(CH2)3-, -(CH2)3-piperidinyl-(CH2)4-, -(CH2)3-piperidinyl-(CH2)5-, -(CH2)3-piperidinyl-(CH2)5-, -(CH2)3-piperidinyl-CH2-, -(CH2)3-piperidinyl-(CH2)2-, -(CH2)3-piperidinyl-(CH2)4-, -(CH2)3-piperidinyl-(CH2)5-, -(CH2)3-piperidinyl-CH2-, -(CH2)3-piperidinyl-CH2-, -(CH2)3-piperidinyl-(CH2)3-, -(CH2)3-piperidinyl-CH2 ... Piperidinyl-(CH2)6-, -(CH2)3-piperidinyl-(CH2)7-, -(CH2)3-piperidinyl-(CH2)8-, -(CH2)4-piperidinyl-CH2-, -(CH2)4-piperidinyl-(CH2)2-, -(CH2)4-piperidinyl-(CH2)3-, -(CH2)4-piperidinyl-(CH2)4-, -(CH2)4-piperidinyl-(CH2)5-, -(CH2)4-piperidinyl-(CH2)6-, -(CH2)4-piperidinyl-(CH2)7-, -(CH2)4-piperidinyl-(CH2)8-, -(CH2)5-piperidinyl-(CH2)1-, -(CH2) 5-Piperidinyl-(CH2)2-, -(CH2)5-piperidinyl-(CH2)3-, -(CH2)5-piperidinyl-(CH2)4-, -(CH2)5-piperidinyl-(CH2)5-, -(CH2)5-piperidinyl-(CH2)6-, -(CH2)5-piperidinyl-(CH2)7-, -(CH2)5-piperidinyl-(CH2)8-, -(CH2)6-piperidinyl-(CH2)1-, -(CH2)6-piperidinyl-(CH2)2-, -(CH2)6-piperidinyl-(CH2)3-, -(CH2)6-piperidinyl-(CH2)4-, -(CH2)6-piperidinyl-(CH2)5-,-(CH2)6-piperidinyl-(CH2)6-, -(CH2)6-piperidinyl-(CH2)7-, -(CH2)6-piperidinyl-(CH2)8-, -(CH2)7-piperidinyl-(CH2)1-, -(CH2)7-piperidinyl-(CH2)2-, -(CH2)7-piperidinyl-(CH2)3-, -(CH2)7-piperidinyl-(CH2)4-, -(CH2)7-piperidinyl-(CH2)8-, -(CH2)8-piperidinyl-CH2-, -(CH2)8-piperidinyl-(CH2)2-, -(CH2)8-piperidinyl-(CH2)3-, -(CH2)8-piperidinyl-(CH2)4- -(CH2)8-piperidine-(CH2)5-, -(CH2)8-piperidine-(CH2)6-, -(CH2)8-piperidine-(CH2)7-, -(CH2)8-piperidine-(CH2)8-, -CH2-piperazinyl-CH2-, -CH2-piperazinyl-(CH2)2-, -CH2-piperazinyl-(CH2)3-, -CH2-piperazinyl-(CH2)4-, -CH2-piperazinyl-(CH2)5-, -CH2-piperazinyl-(CH2)6-, -CH2-piperazinyl-(CH2)7-, -CH2-piperazinyl-(CH2)8-, -(CH2)2-piperazinyl-(CH2)1-, - (CH2)2-piperazinyl-(CH2)2-, -(CH2)2-piperazinyl-(CH2)3-, -(CH2)2-piperazinyl-(CH2)4-, -(CH2)2-piperazinyl-(CH2)5-, -(CH2)2-piperazinyl-(CH2)6-, -(CH2)2-piperazinyl-(CH2)7-, -(CH2)2-piperazinyl-(CH2)8-, -(CH2)3-piperazinyl-CH2-, -(CH2)3-piperazinyl-(CH2)2-, -(CH2)3-piperazinyl-(CH2)3-, -(CH2)3-piperazinyl-(CH2)4-, -(CH2)3-piperazinyl-(CH2)5- -(CH2)3-piperazinyl-(CH2)6-, -(CH2)3-piperazinyl-(CH2)7-, -(CH2)3-piperazinyl-(CH2)8-, -(CH2)4-piperazinyl-CH2-, -(CH2)4-piperazinyl-(CH2)2-, -(CH2)4-piperazinyl-(CH2)3-, -(CH2)4-piperazinyl-(CH2)4-, -(CH2)4-piperazinyl-(CH2)5-, -(CH2)4-piperazinyl-(CH2)6-, -(CH2)4-piperazinyl-(CH2)7-, -(CH2)4-piperazinyl-(CH2)8-, -(CH2)5-piperazinyl-(CH2)1--(CH2)5-piperazinyl-(CH2)2-, -(CH2)5-piperazinyl-(CH2)3-, -(CH2)5-piperazinyl-(CH2)4-, -(CH2)5-piperazinyl-(CH2)5-, -(CH2)5-piperazinyl-(CH2)6-, -(CH2)5-piperazinyl-(CH2)7-, -(CH2)5-piperazinyl-(CH2)8-, -(CH2)6-piperazinyl-(CH2)1-, -(CH2)6-piperazinyl-(CH2)2-, -(CH2)6-piperazinyl-(CH2)3-, -(CH2)6-piperazinyl-(CH2)4-, -(CH2)6-piperazinyl-(CH2) )5-、-(CH2)6-piperazinyl-(CH2)6-、-(CH2)6-piperazinyl-(CH2)7-、-(CH2)6-piperazinyl-(CH2)8-、-(CH2)7-piperazinyl-(CH2)1-、-(CH2)7-piperazinyl-(CH2)2-、-(CH2)7-piperazinyl-(CH2)3-、-(CH2)7-piperazinyl-(CH2)4-、-(CH2)7-piperazinyl-(CH2)8-、-(CH2)8-piperazinyl-CH2-、-(CH2)8-piperazinyl-(CH2)2-、-(CH2)8-piperazinyl-(CH2)3-、-(CH2)8-piperazinyl-(CH2) -4-, -(CH2)8-piperazinyl-(CH2)5-, -(CH2)8-piperazinyl-(CH2)6-, -(CH2)8-piperazinyl-(CH2)7-, -(CH2)8-piperazinyl-(CH2)8-, -CH2-propylidene-CH2-, -CH2-propylidene-(CH2)2-, -CH2-propylidene-(CH2)3-, -CH2-propylidene-(CH2)4-, -CH2-propylidene-(CH2)5-, -CH2-propylidene-(CH2)6-, -CH2-propylidene-(CH2)7-, -CH2-propylidene-(CH2)8-, -(CH2)2-propylidene-(CH2)1-, -(CH2)2- Propylene-(CH2)2-, -(CH2)2-propylidene-(CH2)3-, -(CH2)2-propylidene-(CH2)4-, -(CH2)2-propylidene-(CH2)5-, -(CH2)2-propylidene-(CH2)6-, -(CH2)2-propylidene-(CH2)7-, -(CH2)2-propylidene-(CH2)8-, -(CH2)3-propylidene-CH2-, -(CH2)3-propylidene-(CH2)2-, -(CH2)3-propylidene-(CH2)3-, -(CH2)3-propylidene-(CH2)4-, -(CH2)3-propylidene-(CH2)5-, -(CH2)3-propylidene-(CH2)6--(CH2)3-propylidene-(CH2)7-, -(CH2)3-propylidene-(CH2)8-, -(CH2)4-propylidene-CH2-, -(CH2)4-propylidene-(CH2)2-, -(CH2)4-propylidene-(CH2)3-, -(CH2)4-propylidene-(CH2)4-, -(CH2)4-propylidene-(CH2)5-, -(CH2)4-propylidene-(CH2)6-, -(CH2)4-propylidene-(CH2)7-, -(CH2)4-propylidene-(CH2)8-, -(CH2)5-propylidene-(CH2)1-, -(CH2)5-propylidene-(CH2)2-, -(CH2)5-propylidene- (CH2)3-, -(CH2)5-propylidene-(CH2)4-, -(CH2)5-propylidene-(CH2)5-, -(CH2)5-propylidene-(CH2)6-, -(CH2)5-propylidene-(CH2)7-, -(CH2)5-propylidene-(CH2)8-, -(CH2)6-propylidene-(CH2)1-, -(CH2)6-propylidene-(CH2)2-, -(CH2)6-propylidene-(CH2)3-, -(CH2)6-propylidene-(CH2)4-, -(CH2)6-propylidene-(CH2)5-, -(CH2)6-propylidene-(CH2)6-, -(CH2)6-propylidene-(CH2)7-, - (CH2)6-Propylene-(CH2)8-, -(CH2)7-Propylene-(CH2)1-, -(CH2)7-Propylene-(CH2)2-, -(CH2)7-Propylene-(CH2)3-, -(CH2)7-Propylene-(CH2)4-, -(CH2)7-Propylene-(CH2)8-, -(CH2)8-Propylene-CH2-, -(CH2)8-Propylene-(CH2)2-, -(CH2)8-Propylene-(CH2)3-, -(CH2)8-Propylene-(CH2)4-, -(CH2)8-Propylene-(CH2)5-, -(CH2)8-Propylene-(CH2)6 ... CH2)7-, -(CH2)8-propylidene-(CH2)8-, -CH2-diazacyclic heptane-CH2-, -CH2-diazacyclic heptane-(CH2)2-, -CH2-diazacyclic heptane-(CH2)3-, -CH2-diazacyclic heptane-(CH2)4-, -CH2-diazacyclic heptane-(CH2)5-, -CH2-diazacyclic heptane-(CH2)6-, -CH2-diazacyclic heptane-(CH2)7-, -CH2-diazacyclic heptane-(CH2)8-, -(CH2)2-diazacyclic heptane-(CH2)1-, -(CH2)2-diazacyclic heptane-(CH2)2--(CH2)2-diazacyclic heptanediol-(CH2)3-, -(CH2)2-diazacyclic heptanediol-(CH2)4-, -(CH2)2-diazacyclic heptanediol-(CH2)5-, -(CH2)2-diazacyclic heptanediol-(CH2)6-, -(CH2)2-diazacyclic heptanediol-(CH2)7-, -(CH2)2-diazacyclic heptanediol-(CH2)8-, -(CH2)3-diazacyclic heptanediol-CH2-, -(CH2)3-diazacyclic heptanediol-(CH2)2-, -(CH2)3-diazacyclic heptanediol-(CH2)3-, -(CH2)3-diazacyclic heptanediol-(CH2)4-, - (CH2)3-diazacyclic heptanediyl-(CH2)5-, -(CH2)3-diazacyclic heptanediyl-(CH2)6-, -(CH2)3-diazacyclic heptanediyl-(CH2)7-, -(CH2)3-diazacyclic heptanediyl-(CH2)8-, -(CH2)4-diazacyclic heptanediyl-CH2-, -(CH2)4-diazacyclic heptanediyl-(CH2)2-, -(CH2)4-diazacyclic heptanediyl-(CH2)3-, -(CH2)4-diazacyclic heptanediyl-(CH2)4-, -(CH2)4-diazacyclic heptanediyl-(CH2)5-, -(CH2)4-diazacyclic heptanediyl-(CH2)6-, -(C H2)4-diazacyclic heptanediyl-(CH2)7-, -(CH2)4-diazacyclic heptanediyl-(CH2)8-, -(CH2)5-diazacyclic heptanediyl-(CH2)1-, -(CH2)5-diazacyclic heptanediyl-(CH2)2-, -(CH2)5-diazacyclic heptanediyl-(CH2)3-, -(CH2)5-diazacyclic heptanediyl-(CH2)4-, -(CH2)5-diazacyclic heptanediyl-(CH2)5-, -(CH2)5-diazacyclic heptanediyl-(CH2)6-, -(CH2)5-diazacyclic heptanediyl-(CH2)7-, -(CH2)5-diazacyclic heptanediyl-(CH2)8-, - (CH2)6-diazacyclic heptanediol-(CH2)1-, -(CH2)6-diazacyclic heptanediol-(CH2)2-, -(CH2)6-diazacyclic heptanediol-(CH2)3-, -(CH2)6-diazacyclic heptanediol-(CH2)4-, -(CH2)6-diazacyclic heptanediol-(CH2)5-, -(CH2)6-diazacyclic heptanediol-(CH2)6-, -(CH2)6-diazacyclic heptanediol-(CH2)7-, -(CH2)6-diazacyclic heptanediol-(CH2)8-, -(CH2)7-diazacyclic heptanediol-(CH2)1-, -(CH2)7-diazacyclic heptanediol-(CH2)2-.-(CH2)7-diazacyclic heptanediyl-(CH2)3-, -(CH2)7-diazacyclic heptanediyl-(CH2)4-, -(CH2)7-diazacyclic heptanediyl-(CH2)8-, -(CH2)8-diazacyclic heptanediyl-CH2-, -(CH2)8-diazacyclic heptanediyl-(CH2)2-, -(CH2)8-diazacyclic heptanediyl-(CH2)3-, -(CH2)8-diazacyclic heptanediyl-(CH2)4-, -(CH2)8-diazacyclic heptanediyl-(CH2)5-, -(CH2)8-diazacyclic heptanediyl-(CH2)6-, -(CH2)8-diazacyclic heptanediyl-(CH2)7-, -(C H2)8-diazacyclic heptane-(CH2)8-, -CH2-diazabicyclo[2.2.1]heptane-CH2-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)2-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)3-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)4-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)5-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)6-, -CH2-diazabicyclo[2.2.1]heptane-(CH2)7-, -CH2-diazabicyclo[2.2.1]heptane -(CH2)8-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)1-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)2-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)3-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)4-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)5-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)6-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)7-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)7-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)8 ...8-, -(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)8-, -(CH2)2-diazabi Heterobicyclic [2.2.1] heptane-(CH2)8-, -(CH2)3-diazabicyclic [2.2.1] heptane-CH2-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)2-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)3-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)4-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)5-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)6-, -(CH2)3-diazabicyclic [2.2.1] heptane-(CH2)7-,-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)8-, -(CH2)4-diazabicyclo[2.2.1]heptane-CH2-, -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)2-, -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)3-, -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)4-, -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)5-, -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)6-, -(CH2)4-diazabicyclo[2.2. 1] Heptanediol-(CH2)7-, -(CH2)4-diazabicyclo[2.2.1] Heptanediol-(CH2)8-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)1-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)2-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)3-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)4-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)5-, -(CH2)5-diazabicyclo[2.2.1] Heptanediol-(CH2)6-, - (CH2)5-diazabicyclo[2.2.1]heptane-(CH2)7-, -(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)8-, -(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)1-, -(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)2-, -(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)3-, -(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)4-, -(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)5-, -(CH2)6-diazabicyclo[2.2. .1] Heptane-(CH2)6-, -(CH2)6-diazabicyclo[2.2.1] Heptane-(CH2)7-, -(CH2)6-diazabicyclo[2.2.1] Heptane-(CH2)8-, -(CH2)7-diazabicyclo[2.2.1] Heptane-(CH2)1-, -(CH2)7-diazabicyclo[2.2.1] Heptane-(CH2)2-, -(CH2)7-diazabicyclo[2.2.1] Heptane-(CH2)3-, -(CH2)7-diazabicyclo[2.2.1] Heptane-(CH2)4-, -(CH2)7-diazabicyclo[2.2.1] Heptane-(CH2)8-,-(CH2)8-diazabicyclo[2.2.1]heptane-CH2-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)2-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)3-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)4-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)5-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)6-, -(CH2)8-diazabicyclo[2.2.1]heptane-(CH2)7-, -(CH2)8-diazabicyclo[2.2.1] [3.1.1]Heptane-(CH2)8-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)2-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)3-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)4-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)5-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)6-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2)7-, -CH2-diazabicyclo[3.1.1]Heptane-(CH2) 8-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)1-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)2-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)3-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)4-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)5-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)6-, -(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)7-, -(CH2)2-diazabicyclo [3.1.1]Heptanediol-(CH2)8-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-CH2-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)2-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)3-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)4-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)5-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)6-, -(CH2)3-diazabicyclo[3.1.1]Heptanediol-(CH2)7-,-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)8-, -(CH2)4-diazabicyclo[3.1.1]heptane-CH2-, -(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)2-, -(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)3-, -(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)4-, -(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)5-, -(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)6-, -(CH2)4-diazabicyclo[3.1. 1] Heptane-(CH2)7-, -(CH2)4-diazabicyclo[3.1.1] Heptane-(CH2)8-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)1-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)2-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)3-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)4-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)5-, -(CH2)5-diazabicyclo[3.1.1] Heptane-(CH2)6-, - (CH2)5-diazabicyclo[3.1.1]heptane-(CH2)7-, -(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)8-, -(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)1-, -(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)2-, -(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)3-, -(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)4-, -(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)5-, -(CH2)6-diazabicyclo[3.1.1] .1] Heptane-(CH2)6-, -(CH2)6-diazabicyclo[3.1.1] Heptane-(CH2)7-, -(CH2)6-diazabicyclo[3.1.1] Heptane-(CH2)8-, -(CH2)7-diazabicyclo[3.1.1] Heptane-(CH2)1-, -(CH2)7-diazabicyclo[3.1.1] Heptane-(CH2)2-, -(CH2)7-diazabicyclo[3.1.1] Heptane-(CH2)3-, -(CH2)7-diazabicyclo[3.1.1] Heptane-(CH2)4-, -(CH2)7-diazabicyclo[3.1.1] Heptane-(CH2)8-,-(CH2)8-diazabicyclo[3.1.1]heptane-CH2-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)2-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)3-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)4-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)5-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)6-, -(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)7-, -(CH2)8-diazabicyclo[3.1.1] [3.2.1] Heptane-(CH2)8-, -CH2-diazabicyclo[3.2.1] Octane-CH2-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)2-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)3-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)4-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)5-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)6-, -CH2-diazabicyclo[3.2.1] Octane-(CH2)7-, -CH2-diazabicyclo[3.2.1] Octane-(CH2) 8-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)1-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)2-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)3-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)4-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)5-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)6-, -(CH2)2-diazabicyclo[3.2.1]octane-(CH2)7-, -(CH2)2-diazabicyclo [3.2.1] Octane-(CH2)8-, -(CH2)3-diazabicyclo[3.2.1] Octane-CH2-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)2-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)3-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)4-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)5-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)6-, -(CH2)3-diazabicyclo[3.2.1] Octane-(CH2)7-,-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)8-, -(CH2)4-diazabicyclo[3.2.1]octane-CH2-, -(CH2)4-diazabicyclo[3.2.1]octane-(CH2)2-, -(CH2)4-diazabicyclo[3.2.1]octane-(CH2)3-, -(CH2)4-diazabicyclo[3.2.1]octane-(CH2)4-, -(CH2)4-diazabicyclo[3.2.1]octane-(CH2)5-, -(CH2)4-diazabicyclo[3.2.1]octane-(CH2)6-, -(CH2)4-diazabicyclo[3.2. 1] Octane-(CH2)7-, -(CH2)4-diazabicyclo[3.2.1] Octane-(CH2)8-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)1-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)2-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)3-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)4-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)5-, -(CH2)5-diazabicyclo[3.2.1] Octane-(CH2)6-, - (CH2)5-diazabicyclo[3.2.1]octane-(CH2)7-, -(CH2)5-diazabicyclo[3.2.1]octane-(CH2)8-, -(CH2)6-diazabicyclo[3.2.1]octane-(CH2)1-, -(CH2)6-diazabicyclo[3.2.1]octane-(CH2)2-, -(CH2)6-diazabicyclo[3.2.1]octane-(CH2)3-, -(CH2)6-diazabicyclo[3.2.1]octane-(CH2)4-, -(CH2)6-diazabicyclo[3.2.1]octane-(CH2)5-, -(CH2)6-diazabicyclo[3.2. .1] Octane-(CH2)6-, -(CH2)6-diazabicyclo[3.2.1] Octane-(CH2)7-, -(CH2)6-diazabicyclo[3.2.1] Octane-(CH2)8-, -(CH2)7-diazabicyclo[3.2.1] Octane-(CH2)1-, -(CH2)7-diazabicyclo[3.2.1] Octane-(CH2)2-, -(CH2)7-diazabicyclo[3.2.1] Octane-(CH2)3-, -(CH2)7-diazabicyclo[3.2.1] Octane-(CH2)4-, -(CH2)7-diazabicyclo[3.2.1] Octane-(CH2)8-,-(CH2)8-diazabicyclo[3.2.1]octane-CH2-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)2-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)3-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)4-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)5-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)6-, -(CH2)8-diazabicyclo[3.2.1]octane-(CH2)7-, -(CH2)8-diazabicyclo[3.2.1] Octane-(CH2)8-, -CH2-diazabicyclo[2.2.2] Octane-CH2-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)2-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)3-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)4-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)5-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)6-, -CH2-diazabicyclo[2.2.2] Octane-(CH2)7-, -CH2-diazabicyclo[2.2.2] Octane-(CH2) 8-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)1-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)2-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)3-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)4-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)5-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)6-, -(CH2)2-diazabicyclo[2.2.2]octane-(CH2)7-, -(CH2)2-diazabicyclo [2.2.2]Octenyl-(CH2)8-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-CH2-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)2-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)3-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)4-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)5-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)6-, -(CH2)3-diazabicyclo[2.2.2]Octenyl-(CH2)7-,-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)8-, -(CH2)4-diazabicyclo[2.2.2]octane-CH2-, -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)2-, -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)3-, -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)4-, -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)5-, -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)6-, -(CH2)4-diazabicyclo[2.2. 2] Octane-(CH2)7-, -(CH2)4-diazabicyclo[2.2.2] Octane-(CH2)8-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)1-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)2-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)3-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)4-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)5-, -(CH2)5-diazabicyclo[2.2.2] Octane-(CH2)6-, - (CH2)5-diazabicyclo[2.2.2]octane-(CH2)7-, -(CH2)5-diazabicyclo[2.2.2]octane-(CH2)8-, -(CH2)6-diazabicyclo[2.2.2]octane-(CH2)1-, -(CH2)6-diazabicyclo[2.2.2]octane-(CH2)2-, -(CH2)6-diazabicyclo[2.2.2]octane-(CH2)3-, -(CH2)6-diazabicyclo[2.2.2]octane-(CH2)4-, -(CH2)6-diazabicyclo[2.2.2]octane-(CH2)5-, -(CH2)6-diazabicyclo[2.2.2] .2] Octane-(CH2)6-, -(CH2)6-diazabicyclo[2.2.2] Octane-(CH2)7-, -(CH2)6-diazabicyclo[2.2.2] Octane-(CH2)8-, -(CH2)7-diazabicyclo[2.2.2] Octane-(CH2)1-, -(CH2)7-diazabicyclo[2.2.2] Octane-(CH2)2-, -(CH2)7-diazabicyclo[2.2.2] Octane-(CH2)3-, -(CH2)7-diazabicyclo[2.2.2] Octane-(CH2)4-, -(CH2)7-diazabicyclo[2.2.2] Octane-(CH2)8-,-(CH2)8-diazabicyclo[2.2.2]octane-CH2-, -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)2-, -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)3-, -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)4-, -( CH2)8-diazabicyclo[2.2.2]octane-(CH2)5-, -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)6-, -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)7-, or -(CH2)8-diazabicyclo[2.2.2]octane-(CH2)8-;

[0358] Wherein, the propylidene, the piperidinyl, the piperazine, the diazacycloheptane, the diazabicyclo[2.2.1]heptane, the diazabicyclo[3.1.1]heptane, the diazabicyclo[3.2.1]octane, and the diazabicyclo[2.2.2]octane are independently and optionally further selected from deuterium, optionally deuterated C 1-4 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substituents of alkyl-C(O)NH- or any combination thereof; and

[0359] Each R g11 Independently represent H or C 1-3 alkyl.

[0360] In some embodiments of the compound of formula (I-1), L2 represents the structure of the following formula:

[0361]

[0362] In some embodiments of the compound of formula (I-1), R b1 express:

[0363] Cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]

[0364] Nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-menthyl, m-menthyl, quininecycloyl, adamantyl, noradamantyl, borneol, bicyclo[2.2.1]heptyl, 2-oxobicyclo[2.2.1]heptyl or bicyclo[2.2.1]

[0365] The heptenyl group, optionally selected from D, optionally deuterated C, is composed of one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) groups. 1-4 Alkyl, optional substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally and independently surrounded by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, ...)

[0366] 1-3 or 1-2, or 1) selected from D, optional deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are used for substitution;

[0367] Azacyclobutyl, pyrrolidinyl, imidazoalkyl, pyrazolyl, oxazolyl, thiazoalkyl, piperidinyl, piperazine, morphoyl

[0368] Linyl, thiomorpholinyl, aziridine heptyl, aziridine octyl, diazabicycloheptyl, diazabicyclooctyl, 3-azibicyclo[3.1.0]hexyl, 6-azibicyclo[3.1.1]heptyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azibicyclo[3.2.1]octyl, 3,8-diazabicyclo[3.2.1]octyl,

[0369] 2,5-diazabicyclo[2.2.2]octyl, 3-azaspiro[5.5]undecyl or 7-azaspiro[3.5]nonyl, optionally surrounded by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) selected from D, optionally deuterated C 1-4 Alkyl, optional substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally selected independently by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) selected from D, optionally deuterated C. 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-

[0370] Substitution by substituents, or any combination thereof;

[0371] Phenyl or naphthyl, optionally selected from D, optionally deuterated C by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) 1-4 Alkyl, optional substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally and independently surrounded by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, ...)

[0372] 1-3 or 1-2, or 1) selected from D, optional deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents; or

[0373] Furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrroleyl, imidazolyl, pyrazolyl, triazolyl, pyridyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indoleyl, benzimidazolyl, benzooxazolyl, benzoisooxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphridinyl, cinolinyl, quinazolinyl, quinazolinyl Oxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluoro[3,2-b]pyrryl, pyrrolo[2,1-b]thiazolyl, and imidazo[2,1-b]thiazolyl, optionally selected from D, optionally deuterated C. 1-4 Alkyl, optional substituted C 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally selected independently by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) selected from D, optionally deuterated C. 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4Substituents of alkyl-C(O)NH- or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0374] In some embodiments of the compound of formula (I-1), R b1 express:

[0375]

[0376]

[0377] In some embodiments, the compound of formula (I) is also the compound of formula (I-2):

[0378]

[0379] Where R c1 R c2 R c3 R c4 R c5 R c6 R b 、(R 1a ) n R a R 1a and n are as defined in the compounds of formula (I) above and in their respective embodiments;

[0380] Where R a The following expression is represented:

[0381] R a1 -X2-L1-X1-,

[0382] Where X1 represents N(R) e1 ), O, S, and acetylinyl groups (e.g., C) 2-6 (e.g., C-ynyl), (e.g., C-yl) 2-6 (alkenyl), optional

[0383] Substituted cycloalkylene compounds (e.g., optionally substituted C464) 3-20 Cycloalkyl or optionally substituted C 3-15 Cycloalkylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups or optionally substituted 4- to 15-membered heterocyclic groups), optionally substituted aryl groups (e.g., optionally substituted C-membered heterocyclic groups). 6-10 aryl), or optionally substituted heteroaryl (e.g., optionally substituted 5- to 20-membered heteroaryl or optionally substituted 5- to 15-membered heteroaryl), wherein R e1 Indicates H or C 1-3 Alkyl, or X1 indicates a bond;

[0384] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene (e.g., C1-C) 40 Alkylene, C1-C 30 Alkylene, C1-C 29 Alkane

[0385] Base, C1-C 28 Alkylene, C1-C 27 Alkylene, C1-C 26 Alkylene, C1-C 25 Alkylene, C1-C 24 Alkylene, C1-C 23 Alkylene, C1-C 22 Alkylene, C1-C 21 Alkylene, C1-C 20 Alkylene, C1-C 19 Alkylene, C1-C 18 Alkylene, C1-C 17 Alkylene, C1-C 16 Alkylene, C1-C 15 Alkylene, C1-C 14 Alkylene, C1-C 13 Alkylene, C1-C 12 Alkylene, C1-C 11 Alkylene, C1-C 10 Alkylene, C1-C9 alkylene, C1-C8 alkylene, C1-C7 alkylene, C1-C6 alkylene, C1-C5 alkylene, C1-C4 alkylene, C1-C3 alkylene, or C1-C2 alkylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R inserted into its main carbon chain. e2 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e3 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 With R e3 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein the group R e2 R e3 Or group R e2 With R e3 Any combination thereof breaks one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R e2 Independently selected from O, S, N(R) e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, where R e4 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. e2 At that time, each group R e2 They are not directly connected to each other; each group R e3 Independently selected from optionally substituted cycloalkylene groups (e.g., optionally substituted C14-C ... 3-20 Cycloalkylene, or optionally substituted C 3-15 Cycloalkylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 15-membered heterocyclic groups), optionally substituted arylene groups (e.g., optionally substituted C-membered heterocyclic groups). 6-10arylene), optionally substituted heteroarylene (e.g., optionally substituted 5- to 20-membered heteroarylene, or optionally substituted 5- to 15-membered heteroarylene), alkenyl (e.g., C... 2-6 alkenyl), alkyneyl (e.g., C10), alkenyl), alkyneyl) 2-6 (ethynyl) or any of them

[0386] combination;

[0387] X2 represents C(O), S(O) or S(O)2, or X2 represents a bond;

[0388] R a1 The following expression is represented:

[0389]

[0390] Where R f1 express:

[0391] -NCH2CH2N-;

[0392] Where the symbol * represents the connection point with group X2, R g1 Indicates H or C 1-3 Alkyl, cyclic A indicates a cycloalkyl sub-alkyl (e.g., C10) 3-20 Cycloalkylene, or C 3-15 Cycloalkyl groups or heterocyclic groups (e.g., 4- to 20-membered heterocyclic groups, or 5- to 15-membered heterocyclic groups), (R g2 ) n1 This indicates that ring A can be optionally divided by n1 groups R g2 Replace, n1 represents an integer from 0 to 8, and each R g2 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0393] The symbol ** indicates the connection point with group X2, and Rg3 represents H or C. 1-3 Alkyl, cyclo B

[0394] Indicates cyclohexane (e.g., C10) 3-20 Cycloalkylene, or C 3-15 (cycloalkylene) or heterocyclic (e.g., 4-)

[0395] Up to 20-membered heterocyclic group, or 5- to 15-membered heterocyclic group), (R g4 )n2 This indicates that ring B is optionally divided by n2 groups R g4 Replace, n2 represents integers from 0 to 8, and each R g4 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; or

[0396] Where cyclic C represents a cycloalkylene group (e.g., C10). 3-20 Cycloalkylene, or C 3-15 Cycloalkyl groups or heterocyclic groups (e.g., 4- to 20-membered heterocyclic groups, or 5- to 15-membered heterocyclic groups), (R g5 ) n3 Indicates ring C

[0397] Optionally, it is occupied by n3 groups R g5 Replacement, n3 represents integers from 0 to 8, each R g5 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, hydroxyl, amino

[0398] Thiol, halogen, cyano, or optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0399] R f2 Indicates H, halogen, C 1-3 Alkyl or halogenated C 1-3 alkyl;

[0400] R f3 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Where ring D represents a cycloalkylene group (e.g., C10). 3-20 Cycloalkylene, or C 3-15 Cycloalkylene), heterocyclic (e.g., 4- to 20-membered heterocyclic, or 5- to 15-membered heterocyclic), aryl (e.g., C10-) 6-10 (R) or heteroaryl (e.g., 5- to 20-membered heteroaryl, or 5- to 15-membered heteroaryl), (R) g6 ) n4 This indicates that ring D is optionally surrounded by n4 groups R g6Replacement, n4 represents integers from 0 to 8, each R g6 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0401] R f4 express The symbol *** represents the group R. f5 The connection point, ring E indicates a cycloalkyl subcyclone (e.g., C10). 3-20 Cycloalkylene, or C 3-15 Cycloalkylene), heterocyclic (e.g., 4- to 20-membered heterocyclic, or 5- to 15-membered heterocyclic), aryl (e.g., C10-) 6-10 (R) or heteroaryl (e.g., 5- to 20-membered heteroaryl, or 5- to 15-membered heteroaryl), (R) g7 ) n5 This indicates that ring E is optionally surrounded by n5 groups R g7 Replacement, n5 represents integers from 0 to 8, each R g7 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; and

[0402] R f5 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Where cycloF represents a cycloalkyl group (e.g., C). 3-20 cycloalkyl, or C 3-15 cycloalkyl), heterocyclic (e.g., 4- to 20-membered heterocyclic, or 5- to 15-membered heterocyclic), aryl (e.g., C... 6-10 aryl) or heteroaryl (e.g., 5- to 20-membered heteroaryl, or 5- to 15-membered heteroaryl), (R g8 ) n6 This indicates that ring F is optionally surrounded by n6 groups R g8 Replacement, n6 represents an integer from 0 to 8, each R g8 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; and

[0403] R b This indicates C that is optionally substituted with D or halogen. 1-60 Alkyl (e.g., C1-C) 30 Alkyl, C1-C 29 Alkyl, C1-C 28 Alkyl, C1-

[0404] C 27 Alkyl, C1-C 26 Alkyl, C1-C 25 Alkyl, C1-C 24 Alkyl, C1-C 23 Alkyl, C1-C 22 Alkyl, C1-C 21 Alkyl, C1-C 20 Alkyl, C1-C 19 Alkyl, C1-C 18 Alkyl, C1-C 17 Alkyl, C1-C 16 Alkyl, C1-C 15 Alkyl, C1-

[0405] C 14 Alkyl, C1-C 13 Alkyl, C1-C 12 Alkyl, C1-C 11 Alkyl, C1-C 10 Alkyl, C1-C9 alkyl, C1-C8 alkyl

[0406] C1-C7 alkyl, C1-C6 alkyl, C1-C5 alkyl, C1-C4 alkyl, C1-C3 alkyl, or C1-C2 alkyl), or R b The following expression is represented:

[0407] R b1 -X4-L2-,

[0408] in,

[0409] L2 represents the C of the optionally substituted straight or branched chain. 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9) inserted into its main carbon chain.

[0410] 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 group R 12 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 13 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R 12 With R 13 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein the group R 12 R 13 Or group R 12 With R 13 Any combination of the main carbon chains will combine one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, ...)

[0411] 1-6, 1-5, 1-4, 1-3 or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms are broken; each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 14 Independently represent H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 12 At that time, each group R 12 They are not directly connected to each other; each group R 13 Independently selected from cyclohexene alkyl groups (e.g., C10) 3-20 Cycloalkylene, or C 3-15 Cycloalkylene), heterocyclic (e.g., 4- to 20-membered heterocyclic, or 4- to 15-membered heterocyclic), aryl (e.g., C10-) 6-10 arylene), heteroarylene (e.g., 5- to 20-membered heteroarylene, or 5- to 15-membered heteroarylene), alkenyl (e.g., C... 2-6 alkenyl), alkyneyl (e.g., C10), alkenyl), alkyneyl) 2-6 (ethynyl) or any combination thereof, wherein the cycloalkylene, the heterocyclic group, the aryl group and the heteroaryl group are optionally further selected independently from D, optionally deuterated C. 1-4 Alkyl, optionally deuterated C 3-6Cycloalkyl, hydroxyl, amino, mercapto, halogen, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0412] X4 represents N(R) 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(=S), S, S(O),

[0413] S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optional substituted cycloalkylene compounds (e.g., optional substituted C... 3-20 Cycloalkylene, or optionally substituted C 3-15 Cycloalkylene, optionally substituted arylene (e.g., optionally substituted C464) 6-20 aryl, or optionally substituted C 6-10 arylene), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 4- to 15-membered heterocyclic groups), optionally substituted heteroarylene groups (e.g., optionally substituted 5- to 20-membered heteroarylene groups, or optionally substituted 5- to 15-membered heteroarylene groups), triazolyl-NH-, or -NH-triazolyl, wherein R 15 Indicates H or C 1-3 Alkyl, or X4, indicates a bond; and

[0414] R b1 This indicates optional substituted cycloalkyl groups (e.g., optional substituted C14 groups). 3-20 cycloalkyl, or optionally substituted C 3-15 cycloalkyl), optionally substituted aryl (e.g., optionally substituted C) 6-20 aryl, or optionally substituted C 6-10 Aryl), optionally substituted heterocyclic groups (e.g., optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 4- to 15-membered heterocyclic groups) or optionally substituted heteroaryl groups (e.g., optionally substituted 5- to 20-membered heteroaryl groups, or optionally substituted 5- to 15-membered heteroaryl groups).

[0415] In some embodiments of the compound of formula (I-2), R a The following expression is represented:

[0416] R a1 -X2-L1-X1-,

[0417] Where X1 represents N(R)e1 ), O, S, C 2-6 Ethyne group, C 2-6 alkenyl, optional substituted C 3-20 Cycloalkylene (e.g., optionally substituted C14) 3-15 Cycloalkylene groups), optionally substituted 4- to 20-membered heterocyclic alkylene groups (e.g., optionally substituted 4- to 15-membered heterocyclic alkylene groups), optionally substituted C-membered heterocyclic alkylene groups. 6-15 aryl (e.g., optionally substituted C) 6-10 aryl), or optionally substituted 5- to 20-membered heteroaryl (e.g., optionally substituted 5- to 15-membered heteroaryl), wherein R e1 Indicates H or C 1-3 Alkyl, or X1 indicates a bond;

[0418] L1 represents either the linear or branched chain C, which can be substituted. 1-60 Alkylene (e.g., C1-C) 40 Alkylene, C1-C 30 Alkylene, C1-C 29 Alkylene, C1-C 28 Alkylene, C1-C 27 Alkylene, C1-C 26 Alkylene, C1-C 25 Alkylene, C1-C 24 Alkylene, C1-

[0419] C 23 Alkylene, C1-C 22 Alkylene, C1-C 21 Alkylene, C1-C 20 Alkylene, C1-C 19 Alkylene, C1-C 18 Alkylene, C1-C 17 Alkylene, C1-C 16 Alkylene, C1-C 15 Alkylene, C1-C 14 Alkylene, C1-C 13 Alkylene, C1-

[0420] C 12 Alkylene, C1-C 11 Alkylene, C1-C 10 Alkylene, C1-C9 alkylene, C1-C8 alkylene, C1-C7 alkylene, C1-C6 alkylene, C1-C5 alkylene, C1-C4 alkylene, C1-C3 alkylene, or C1-C2 alkylene), or with one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R inserted into its main carbon chain.e2 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e3 And / or one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups R e2 With R e3 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-

[0421] C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-

[0422] C 18 Alkylene, C2-C 17 Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein

[0423] The group R e2 R e3 Or group R e2 With R e3 Any combination thereof breaks one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R e2Independently selected from O, S, N(R) e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH, or NHS(O)2, where R e4 Indicates H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. e2 At that time, each group R e2 They are not directly connected to each other; each group R e3 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 Alynyl groups or any combination thereof, wherein the straight-chain or branched C 1-60 Alkylene and the straight-chain or branched C 2-60 Each alkylene group may be independently and optionally further selected from deuterium, or optionally deuterated C. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, nitro, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-

[0424] Substituents of CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-, or any combination thereof;

[0425] X2 represents C(O) or S(O)2, or X2 represents a bond;

[0426] R a1 The following expression is represented:

[0427]

[0428] Where Rf1 express:

[0429] -NCH2CH2N-;

[0430] Where the symbol * represents the connection point with group X2, R g1 Indicates H or C 1-3 Alkyl, cyclic A represents C 3-20 Cycloalkylene or 4- to 20-membered heterocyclic alkylene, (R g2 ) n1 This indicates that ring A can be optionally divided by n1 groups R g2 Replace, n1 represents an integer from 0 to 8, and each R g2 The same or different and each independently selected from deuterium,

[0431] Optional deuterated C 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-4 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-) or any combination thereof;

[0432] Where the symbol ** represents the connection point with group X2, R g3 Indicates H or C 1-3 Alkyl, cyclo B

[0433] Indicate C 3-20 Cycloalkylene or 4- to 20-membered heterocyclic alkylene, (R g4 ) n2 This indicates that ring B is optionally divided by n2 groups R g4 Replace, n2 represents integers from 0 to 8, and each R g4 C that are the same or different and are independently selected from deuterium, or can be deuterated.1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-4 Alkyl groups, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-

[0434] or any combination thereof; or

[0435] Where ring C represents C 3-20 Cycloalkylene or 4- to 20-membered heterocyclic alkylene, (R g5 ) n3 This indicates that the ring C is optionally surrounded by n3 groups R. g5 Replacement, n3 represents integers from 0 to 8, each R g5 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C)1-4 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-) or any combination thereof;

[0436] R f2 Indicates H, halogen, C 1-3 Alkyl or halogenated C 1-3 Alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-);

[0437] R f3 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 Alkyl groups (e.g., F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), Where ring D represents C 3-20 Cycloalkylene, 4- to 20-membered heterocyclic cycloalkylene, C 6-15 arylene or 5- to 20-membered heteroarylene, (R g6 ) n4 This indicates that ring D is optionally surrounded by n4 groups R g6 Replacement, n4 represents integers from 0 to 8, each R g6 The same or different and each independently selected from optional deuterated C 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-4Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-) or any combination thereof;

[0438] R f4 express The symbol *** represents the group R. f5 The connection point, ring E represents C. 3-20 Cycloalkylene, 4- to 20-membered heterocyclic cycloalkylene, C 6-15 arylene or 5- to 20-membered heteroarylene, (R g7 ) n5 This indicates that ring E is optionally surrounded by n5 groups R g7 Replacement, n5 represents integers from 0 to 8, each R g7 The same or different and each independently selected from optional deuterated C 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-4 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-) or any combination thereof; and

[0439] R f5 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Where ring F represents C 3-20 Cycloalkyl, 4- to 20-membered heterocyclic, C 6-15 Aryl or 5- to 20-membered heteroaryl,

[0440] (R g8 ) n6 This indicates that ring F is optionally surrounded by n6 groups R g8 Replacement, n6 represents an integer from 0 to 8, each R g8The same or different and each independently selected from optional deuterated C 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkoxy groups (such as methoxy, ethoxy, or propoxy groups), halogenated C groups 1-6 Alkyl groups (e.g., halogenated C) 1-4 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-,

[0441] Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-

[0442] NH2-C 1-6 Alkylene (e.g., NH2-C) 1-4 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-) or any combination thereof;

[0443] In some embodiments of the compound of formula (I-2), X1 represents a bond.

[0444] In some embodiments of the compound of formula (I-2), X1 represents: N(R e1 ), O, S, C 2-6 Ethyne group, C 2-6 alkenyl, optional substituted C 3-20 Cycloalkylene, optionally substituted 4- to 20-membered heterocyclic alkylene, optionally substituted C 6-15 arylene, or optionally substituted 5- to 20-membered heteroarylene, wherein R e1 Indicates H or C 1-3 Alkyl, wherein the C 3-20 Cycloalkylene, the 4- to 20-membered heterocyclic alkylene group, the C 6-15 The arylene and the 5- to 20-membered heteroarylene are each optionally and independently selected from D, optionally deuterated C, by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) groups. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-, or any combination thereof, are substituted with substituents.

[0445] In some embodiments of the compound of formula (I-2), X1 represents N(R) e1 ), O, S, C 2-6 Ethyne or C 2-6 alkenyl, wherein R e1 Indicates H or C 1-3 alkyl.

[0446] In some embodiments of the compound of formula (I-2), X1 represents:

[0447] Cyclopropylene, Cyclobutylene, Cyclopentene, Cyclopentenylene, Cyclohexylene, Cyclohexenylene, Cycloheptylene, Cyclooctylene

[0448] alkyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptaneyl, spiro[2.5]octaneyl, spiro[3.5]nonaneyl, spiro[4.4]nonaneyl, spiro[4.5]decaneyl, spiro[5.5]undecaneyl, p-menthaneyl, m-menthaneyl, quininecycloyl, adamantyl, noradamantyl, borneolyl, bicyclic

[0449] [2.2.1]Heptane subunit, 2-oxobicyclo[2.2.1]heptane subunit or bicyclo[2.2.1]heptene subunit, optionally surrounded by one or more (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) selected from D, optionally deuterated C 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 alkyl-C(O)NH- or any combination thereof substituents

[0450] replace;

[0451] Phenylidene or naphthylene, optionally selected from D by one or more (e.g., 1-5, 1-4, 1-3, or 1-2, or 1) groups.

[0452] C of the selected deuterium generation 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH-, or any combination thereof

[0453] Substitution;

[0454] nitrosobutyl, oxo-nitrosobutyl, pyridinealkyl, imidazoalkyl, pyridinealkyl, tetrahydrofuranyl, nitrosobutyl

[0455] Tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiophenyl, oxazolidinyl, thiazolyl, piperidinyl, piperazinyl, morpholinyl, thiomorpholinyl, dioxazolidinyl, aziridine heptaneyl, aziridine octaneyl, diazabicycloheptaneyl, diazabicyclooctaneyl, 3-azabicyclo[3.1.0]hexaneyl, 6-azabicyclo[3.1.1]heptaneyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octaneyl, 3,8-diazabicyclo[3.2.1]octaneyl, 2,5-diazabicyclo[2.2.2]octaneyl, 3-azaspiro[5.5]

[0456] Undecanediol or 7-azaspiro[3.5]nonanediol, optionally surrounded by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1) selected from D, optionally deuterated C 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof, or substituents such as alkyl-C(O)NH-, or alkyl-C(O)NH-, are used; or alkyl-furanyl, alkyl-oxazolyl, alkyl-isooxazolyl, alkyl-oxadiazolyl, alkyl-thiophenyl, alkyl-thiazolyl, alkyl-isothiazolyl, alkyl-thiazolyl, etc.

[0457] Diazolyl, pyridineyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, indoleyl, isoydinolyl, benzofuranyl, isoyfuranyl, benzothiopheneyl, indazoleyl, benzimidazoleyl, benzoxazolyl, benziisoxazolyl, benzothiazolyl, benziisothiazolyl, benzotriazolyl, benzo[ [2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolineyl, isoquinolineyl, naphthinyl, cenolinyl, quinolineyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidineyl, imidazo[1,2-a]pyridinyl, 1H-pyrrolo

[0458] [3,2-b]pyridinyl subunit, 1H-pyrrolo[2,3-b]pyridinyl subunit, 4H-fluoro[3,2-b]pyrrolo subunit, pyrrolo[2,1-b]thiazole subunit or imidazo[2,1-b]thiazole subunit, optionally selected from D, optionally deuterated C. 1-4 Alkyl, Halogenated C 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Substituents of alkyl-C(O)NH- or any combination thereof. In embodiments of this disclosure, the number of substituents is not limited in principle or is automatically limited by the size of the building blocks.

[0459] In some embodiments of the compound of formula (I-2), X1 represents NH, N(CH3), O, S, ethynyl or vinylene.

[0460] In some embodiments of the compound of formula (I-2), X1 represents:

[0461]

[0462]

[0463] The symbol # indicates the connection point with group L1.

[0464] In some embodiments of the compound of formula (I-2), R a1 The following expression is represented:

[0465]

[0466] Where R f1 express:

[0467] -NCH2CH2N-;

[0468] Where the symbol * represents the connection point with group X2, R g1 Indicates H or C 1-3Alkyl, cyclic A represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[3.5]nonaneylene, spiro[4.5]dec ... [5.5] Undecanediyl, p-menthanediyl, m-menthanediyl, quininecycloyl, adamantyl, noradamantyl, borneolyl, bicyclo[2.2.1]heptanediyl, 2-oxobicyclo[2.2.1]heptanediyl, bicyclo[2.2.1]heptenediyl, azapyrocyclobutyl, oxopyrocyclobutyl, pyridinealkyl, imidazoalkyl, pyrazolalkyl, tetrahydrofuranyl Tetrahydropyranyl, Tetrahydrothiophenyl, Tetrahydrothiophenyl, Ixazoalkyl, Ithiazoalkyl, Piperidinyl, Piperazinyl, Morpholinyl, Thionomorpholinyl, Dioxacyclohexyl, Azacyclic heptaneyl, Azacyclic octaneyl, Diazacyclic heptaneyl, Diazacyclic octaneyl, 3-azabicyclo[3.1.0]hexaneyl, 6-azabicyclo[3.1.1]heptaneyl , 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octanediol, 3,8-diazabicyclo[3.2.1]octanediol, 2,5-diazabicyclo[2.2.2]octanediol, 3-azaspiro[5.5]undecanediol or 7-azaspiro[3.5]nonanediol, and

[0469] (R g2 ) n1 This indicates that ring A can be optionally divided by n1 groups R g2 Replace, n1 represents an integer from 0 to 8, each R g2 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-

[0470] C 1-6 alkylene groups or any combination thereof;

[0471] Where the symbol ** represents the connection point with group X2, R g3 Indicates H or C 1-3Alkyl, cyclic B represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[3.5]nonaneylene, spiro[4.4]decaneylene, spiro[4.5]decaneylene, spiro[3.5]nonaneylene, spiro[4.5]dec ... [5.5] Undecanediyl, p-menthanediyl, m-menthanediyl, quininecycloyl, adamantyl, noradamantyl, borneolyl, bicyclo[2.2.1]heptanediyl, 2-oxobicyclo[2.2.1]heptanediyl, bicyclo[2.2.1]heptenediyl, azapyrocyclobutyl, oxopyrocyclobutyl, pyridinealkyl, imidazoalkyl, pyrazolalkyl, tetrahydrofuranyl Tetrahydropyranyl, Tetrahydrothiophenyl, Tetrahydrothiophenyl, Ixazoalkyl, Ithiazoalkyl, Piperidinyl, Piperazinyl, Morpholinyl, Thionomorpholinyl, Dioxacyclohexyl, Azacyclic heptaneyl, Azacyclic octaneyl, Diazacyclic heptaneyl, Diazacyclic octaneyl, 3-azabicyclo[3.1.0]hexaneyl, 6-azabicyclo[3.1.1]heptaneyl , 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octanediol, 3,8-diazabicyclo[3.2.1]octanediol, 2,5-diazabicyclo[2.2.2]octanediol, 3-azaspiro[5.5]undecanediol or 7-azaspiro[3.5]nonanediol, and

[0472] (R g4 ) n2 This indicates that ring B is optionally divided by n2 groups R g4 Replace, n2 represents integers from 0 to 8, each R g4 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-

[0473] C 1-6 alkylene groups or any combination thereof; or

[0474] Wherein, cycloC represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[ 5.5] Undecanediyl, p-menthanediyl, m-menthanediyl, quininecycloyl, adamantyl, noradamantyl, borneolyl, bicyclo[2.2.1]heptanediyl, 2-oxobicyclo[2.2.1]heptanediyl, bicyclo[2.2.1]heptenediyl, azapyrocyclobutyl, oxopyrocyclobutyl, pyridinealkyl, imidazoalkyl, pyrazolalkyl, tetrahydrofuranyl, Tetrahydropyranyl, Tetrahydrothiophenyl, Tetrahydrothiophenyl, Ixazoalkyl, Ithiazoalkyl, Piperidinyl, Piperazinyl, Morpholinyl, Thionomorpholinyl, Dioxacyclohexyl, Azacyclic heptaneyl, Azacyclic octaneyl, Diazacyclic heptaneyl, Diazacyclic octaneyl, 3-azabicyclo[3.1.0]hexaneyl, 6-azabicyclo[3.1.1]heptaneyl , 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octanediol, 3,8-diazabicyclo[3.2.1]octanediol, 2,5-diazabicyclo[2.2.2]octanediol, 3-azaspiro[5.5]undecanediol or 7-azaspiro[3.5]nonanediol, and

[0475] (R g5 ) n3 This indicates that the ring C is optionally surrounded by n3 groups R. g5 Replacement, n3 represents integers from 0 to 8, each R g5 C that are the same or different and are independently selected from deuterium, or can be deuterated. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, and optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-

[0476] C 1-6 alkylene groups or any combination thereof;

[0477] R f2 Indicates H, halogen, C 1-3 Alkyl or halogenated C 1-3 alkyl;

[0478] R f3 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Wherein ring D represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[5.5]undecaneylene, p-menthaneylene, m-menthaneylene, quininecycloylene, adamantylene, noradamantylene, borneolylene, bicyclo[2.2.1]heptaneylene 2-Oxadicyclo[2.2.1]heptanediyl, bicyclo[2.2.1]heptenediyl, azacyclobutyl, oxadicyclobutyl, pyridinealkyl, imidazoalkyl, pyrazolidine, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolalkyl, thiazoalkyl, piperidinyl, piperazineyl, morpholinyl, thiomorpholinyl, dioxadicyclohexyl, azacycloheptanediyl, azacyclooctanediyl, diazacycloheptanediyl, diazacyclooctanediyl, 3-azabicyclo[3.1.0]hexanediyl, 6-azabicyclo

[0479] [3.1.1]Heptanediyl, 2,5-diazabicyclo[2.2.1]Heptyl, 3,6-diazabicyclo[3.1.1]Heptyl, 3-azabicyclo[3.2.1]Octenyl, 3,8-diazabicyclo[3.2.1]Octenyl, 2,5-diazabicyclo[2.2.2]Octenyl, 3-azaspiro[5.5]Undecanediyl, 7-azaspiro[3.5]Nonanediyl, Phenylidene, Naphthyl, Furanyl, Ixazolyl, Isooxazolyl, Ixadiazolyl, Ixaphene, Ithiazolyl, Isothiazolyl, Ithiadiazolyl, Pyrrolyl, Imidazolyl, Ipyrazolyl, Triazolyl, Pyridinyl, Pyrimidinyl, Iridazinyl, pyrazinyl, indoleyl, isoindoleyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indazoleyl, benzoimidazolyl, benzoxazolyl, benzoisoxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphthinyl, cinolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidine, imidazo[1,2-a]pyridinyl, 1H-pyrrolo

[0480] [3,2-b]pyridinyl subunit, 1H-pyrrolo[2,3-b]pyridinyl subunit, 4H-fluoro[3,2-b]pyrroleyl subunit, pyrrolo[2,1-b]thiazole subunit or imidazo[2,1-b]thiazole subunit, and

[0481] (Rg6 ) n4 This indicates that ring D is optionally surrounded by n4 groups R g6 Replacement, n4 represents integers from 0 to 8, each R g6 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, hydroxyl

[0482] Amino, mercapto, halogen, cyano, or optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof;

[0483] R f4 express The symbol *** represents the group R. f5 The connection point,

[0484] Cyclo-E represents: cyclopropylene, cyclobutylene, cyclopentylene, cyclopentenylene, cyclohexylene, cyclohexenylene, cycloheptylene, cyclooctylene, decahydronaphthylene, octahydrocyclopentadienylene, octahydro-1H-indenylene, spiro[3.3]heptaneylene, spiro[2.5]octaneylene, spiro[3.5]nonaneylene, spiro[4.4]nonaneylene, spiro[4.5]decaneylene, spiro[5.5]

[0485] Undecanediyl, p-menthanediyl, m-menthanediyl, quininecycloyl, adamantyl, noradamantyl, borneolyl, bicyclo[2.2.1]heptanediyl, 2-oxobicyclo[2.2.1]heptanediyl, bicyclo[2.2.1]heptenediyl, azacyclobutyl, oxazolidinyl, pyrrolidine, imidazoalkyl, pyrazolidine, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolidine, thiazoalkyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, dioxazolyl Cyclohexyl, azacycloheptanyl, azacyclooctaneyl, diazacycloheptanyl, diazacyclooctaneyl, 3-azabicyclo[3.1.0]hexaneyl, 6-azabicyclo[3.1.1]heptanyl, 2,5-diazabicyclo[2.2.1]heptyl, 3,6-diazabicyclo[3.1.1]heptyl, 3-azabicyclo[3.2.1]octaneyl, 3,8-diazabicyclo[3.2.1]octaneyl, 2,5-diazabicyclo[2.2.2]octaneyl, 3-azaspiro[5.5]undecaneyl 7-azaspiro[3.5]nonanediyl, phenylene, naphthylene, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophene, thiazolyl, isothiazolyl, thiazolyl, pyrrolyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiophene, indoleyl, benzimidazolyl, benzoxazolyl, benziisooxazolyl, benziisothiazolyl, benzitriazolyl , benzo[2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolineyl, isoquinolineyl, naphthinyl, cinnamolineyl, quinolineyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridinyl, pyrazolo[1,5-a]pyrimidineyl, imidazo[1,2-a]pyridinyl, 1H-pyrrolo[3,2-b]pyridinyl, 1H-pyrrolo[2,3-b]pyridinyl, 4H-fluoro[3,2-b]pyrroleyl, pyrrolo[2,1-

[0486] [b]thiazole subunit or imidazo[2,1-b]thiazole subunit, and

[0487] (R g7 ) n5 This indicates that ring E is optionally surrounded by n5 groups R g7 Replacement, n5 represents integers from 0 to 8, each R g7 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, hydroxyl

[0488] Amino, mercapto, halogen, cyano, or optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 alkylene groups or any combination thereof; and

[0489] R f5 Indicates H, halogen, C 1-3 Alkyl, Halogenated C 1-3 alkyl, Where ring F represents:

[0490] Cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, cycloheptyl, cyclooctyl, decahydronaphthyl, octahydrocyclopentadienyl, octahydro-1H-indenyl, spiro[3.3]heptyl, spiro[2.5]octyl, spiro[3.5]nonyl, spiro[4.4]nonyl, spiro[4.5]decyl, spiro[5.5]undecyl, p-mentheptyl, m-mentheptyl, quininecycloyl, adamantyl, noradamantyl, borneol, bicyclo[2.2.1]heptyl, 2-oxobicyclo[2.2.1]heptyl, bicyclo[2.2.1]heptenyl, aziridine, oxaziridine, pyrrolidinyl, imidazoalkyl, pyrazolyl, tetrahydrofuranyl, tetrahydropyran Tetrahydrothiophenyl, tetrahydrothiaranyl, oxazolyl, thiazolyl, piperidinyl, piperazine, morpholinyl, thiomorpholinyl, dioxacyclohexyl, aziridine, aziridine, diaziridine, diaziridine, 3-aziridine[3.1.0]hexyl, 6-aziridine[3.1.1]heptyl, 2,5-aziridine[2.2.1]heptyl, 3,6-aziridine[3.1.1]heptyl, 3-aziridine[3.2.1]octyl, 3,8-aziridine[3.2.1]octyl, 2,5-aziridine[2.2.2]octyl, 3-aziridine[5.5]undecyl, 7-aziridine

[0491] [3.5] Nonyl, phenyl, naphthyl, furanyl, oxazolyl, isoxazolyl, oxadiazolyl, thiophenyl, thiazolyl, isothiazolyl, thiadiazolyl, pyrroleyl, imidazolyl, pyrazolyl, triazolyl, pyridinyl, pyrimidinyl, pyrazinyl, indoleyl, isindoleyl, benzofuranyl, isobenzofuranyl, benzothiophenyl, indoleyl, benzimidazolyl, benzooxazolyl, benzoisooxazolyl, benzothiazolyl, benzoisothiazolyl, benzotriazolyl, benzo[…]

[0492] [2,1,3]oxadiazolyl, benzo[2,1,3]thiadiazolyl, benzo[1,2,3]thiadiazolyl, quinolinyl, isoquinolinyl, naphridyl, cenolinyl, quinazolinyl, quinoxalinyl, phthalazinyl, pyrazolo[1,5-a]pyridyl, pyrazolo[1,5-a]pyrimidinyl, imidazo[1,2-a]pyridyl, 1H-pyrrolo[3,2-b]pyridyl, 1H-pyrrolo[2,3-b]pyridyl, 4H-fluorine

[0493] [3,2-b]pyrrolo, pyrrolo[2,1-b]thiazolyl, or imidazo[2,1-b]thiazolyl, and

[0494] (R g8 ) n6 This indicates that ring F is optionally surrounded by n6 groups R g8 Replacement, n6 represents an integer from 0 to 8, each R g8 The same or different and each independently selected from optional deuterated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, hydroxyl

[0495] Amino, mercapto, halogen, cyano, or optionally deuterated C 1-6 Alkoxy, halogenated C 1-6 Alkyl, NH2-C 1-6 Alkylenes or any combination thereof.

[0496] In some embodiments of the compound of formula (I-2), R a1 The following expression is represented:

[0497]

[0498]

[0499]

[0500] In some embodiments of the compound of formula (I-2), L1 represents the structure of the following formula:

[0501] ##-(C(R a1 (R) a2 )) m1 -(R e2 (C(R a3 (R) a4 )) m2 ) p1 -;

[0502] ##-(C(R a1 (R) a2 )) m1 -(R e2 (C(R a3)(R a4 )) m2 ) p1 -(R e2 (C(R a5 )(R a6 )) m3 ) p2 -;

[0503] ##-(C(R a1 )(R a2 )) m1 -(R e2 (C(R a3 )(R a4 )) m2 ) p1 -(R e2 (C(R a5 )(R a6 )) m3 ) p2 -(R e2 (C(R a7 )(R a8 )) m4 ) p3 -;

[0504] ##-(C(R a1 )(R a2 )) m1 -(R e3 (C(R a3 )(R a4 )) m2 ) p1 -;

[0505] ##-(C(R a1 )(R a2 )) m1 -(R e3 (C(R a3 )(R a4 )) m2 ) p1 -(R e3 (C(R a5 )(R a6 )) m3 ) p2 -;

[0506] ##-(C(R a1 )(R a2 )) m1 -(R e3 (C(R a3 )(R a4 )) m2 ) p1 -(R e3(C(R a5 )(R a6 )) m3 ) p2 -(R e3 (C(R a7 )(R a8 )) m4 ) p3 -;

[0507] ##-(C(R a1 )(R a2 )) m1 -(R e2 -R e3 -(C(R a3 )(R a4 )) m2 ) p1 -;

[0508] ##-(C(R a1 )(R a2 )) m1 -(R e2 (C(R a3 )(R a4 )) m2 ) p1 -(R e3 (C(R a5 )(R a6 )) m3 ) p2 -;

[0509] ##-(C(R a1 )(R<​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​​e2 Independently selected from O, S, N(R) e4 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where each R e4 Independently represent H or C 1-3 Alkyl groups; R groups e3 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkyl groups (e.g., methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-6 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-3 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C 1-6 Alkyl-NHC(O)- (e.g., C 1-4Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- (e.g., C 1-4 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof, are substituted with substituents;

[0512] R a1 R a2 R a3 R a4 R a5 R a6 R a7 and R a8 Each group independently represents H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, and optionally deuterated C. 1-6 Alkyl groups (e.g., optionally deuterated C4) 1-4 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, and halogenated C. 1-6 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2-, or CH2ClCH2-, optionally deuterated C 3-6 Cycloalkyl groups (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), optionally deuterated C 1-6 Alkoxy groups (e.g., C) 1-3 Alkyl groups (e.g., methoxy, ethoxy, or propoxy), optionally deuterated C 1-6 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-), NH2-C 1-6 Alkylene (e.g., NH2-C) 1-3 Alkylene (e.g., NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), optionally deuterated C 1-6 Alkyl-NHC(O)- (e.g., C 1-4 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- (e.g., C 1-4Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof;

[0513] The symbol ## indicates the connection point with group X1; and

[0514] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0515] In some embodiments of the compound of formula (I-2), L1 represents the structure of the following formula:

[0516] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -;

[0517] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -(O(C(R a5 (R) a6 )) m3 ) p2 -;

[0518] ##-(C(R a1 (R) a2 )) m1 -(O(C(R a3 (R) a4 )) m2 ) p1 -(O(C(R a5 (R) a6 )) m3 ) p2 -(O(C(R a7 (R) a8 )) m4 ) p3 -;

[0519] ##-(C(R a1 (R) a2 )) m1 -(N(R g9 )(C(R a3 (R)a4 )) m2 ) p1 -;

[0520] ##-(C(R a1 )(R a2 )) m1 -(N(R g9 )(C(R a3 )(R a4 )) m2 ) p1 -(N(R g9 )(C(R a5 )(R a6 )) m3 ) p2 -;

[0521] ##-(C(R a1 )(R a2 )) m1 -(N(R g9 )(C(R a3 )(R a4 )) m2 ) p1 -(N(R g9 )(C(R a5 )(R a6 )) m3 ) p2 -(N(R g9 )(C(R a7 )(R a8 )) m4 ) p3 -;

[0522] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -;

[0523] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(C(O)NH-(C(R a5 )(R a6 )) m3 ) p2 -;

[0524] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(C(O)NH-(C(R a5 )(R a6 )) m3 ) p2 -(C(O)NH-

[0525] (C(R a7 )(R a8 )) m4 ) p3 -;

[0526] ##-(C(R a1 )(R a2 )) m1 -(C(O)NH-(C(R a3 )(R a4 )) m2 ) p1 -(O-(C(R a5 )(R a6 )) m3 ) p2 -;

[0527] ##-(C(R a1 )(R a2 )) m1 -C(O)NH-(C(R a3 )(R a4 )) m2 -(O(C(R a5 )(R a6 )) m3 ) p1 -;

[0528] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 ) p1 -;

[0529] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 )p1 -(O-(C(R a5 )(R a6 )) m3 ) p2 -;

[0530] ##-(C(R a1 )(R a2 )) m1 -(NHC(O)-(C(R a3 )(R a4 )) m2 ) p1 -(O-(C(R a5 )(R a6 )) m3 ) p2 -(O-(C(R a7 )(R a8 )) m4 ) p3 -;

[0531] ##-(C(R a1 )(R a2 )) m1 -NHC(O)-(C(R a3 )(R a4 )) m2 -(O(C(R a5 )(R a6 )) m3 ) p1 -;

[0532] ##-(C(R a1 )(R a2 )) m1 -NHC(O)NH-(C(R a3 )(R a4 )) m2 -;

[0533] ##-(C(R a1 )(R a2 )) m1 -C(O)-(C(R a3 )(R a4 )) m2 -;

[0534] ##-(C(R a1 )(R a2 )) m1 -C(S)-(C(R a3 )(R a4 )) m2 -;

[0535] ##-(C(Ra1 (R) a2 )) m1 -S-(C(R a3 (R) a4 )) m2 -;

[0536] ##-(C(R a1 (R) a2 )) m1 -(C 6-10 Aspartic-(C(R) a3 (R) a4 )) m2 ) p1 -;

[0537] ##-(C(R a1 (R) a2 )) m1 -(C 6-10 Aspartic-(C(R) a3 (R) a4 )) m2 ) p1 -C 6-10 Aspartic-(C(R) a5 (R) a6 )) m3 -;

[0538] ##-(C(R a1 (R) a2 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a3 (R) a4 )) m2 ) p1 -;

[0539] ##-(C(R a1 (R) a2 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a3 (R) a4 )) m2 ) p1 -(4-to-15-membered heterocyclic group-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0540] ##-(C(R a1 (R) a2 )) m1 -(5-to-15-methylheteroaryl-(C(R) a3 (R) a4 ))m2 ) p1 -;

[0541] ##-(C(R a1 (R) a2 )) m1 -(5-to-15-methylheteroaryl-(C(R) a3 (R) a4 )) m2 ) p1 -(5-to-15-methylheteroaryl-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0542] ##-(C(R a1 (R) a2 )) m1 -(C 3-15 Cycloalkylene-(C(R) a3 (R) a4 )) m2 ) p1 -;or

[0543] ##-(C(R a1 (R) a2 )) m1 -(C 3-15 Cycloalkylene-(C(R) a3 (R) a4 )) m2 ) p1 -(C 3-15 Cycloalkylene-(C(R) a5 (R) a6 )) m3 ) p2 -;

[0544] Among them, each R g9 Independently represent H or C 1-3 alkyl;

[0545] The C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-6 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, optional deuterated C 1-6 Alkoxy, optional deuterated C 1-6 Alkyl-NH-, Halogenated C 1-6 Alkyl, NH2-C 1-6 Alkylene, optional deuterated C1-6 Alkyl-NHC(O)-, optionally deuterated C 1-6 Substitution by alkyl-C(O)NH-, cyano, or any combination thereof;

[0546] R a1 R a2 R a3 R a4 R a5 R a6 R a7 and R a8 Each group independently represents H, deuterium, hydroxyl, amino, mercapto, nitro, halogen, cyano, and optionally deuterated C. 1-6 Alkyl, Halogenated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, optional deuterated C 1-6 Alkoxy, optional deuterated C 1-6 Alkyl-NH-, NH2-C 1-6 Alkylene, optional deuterated C 1-6 Alkyl-NHC(O)-, optionally deuterated C 1-6 Alkyl-C(O)NH- or any combination thereof;

[0547] The symbol ## indicates the connection point with group X1; and

[0548] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0549] In some embodiments of the compound of formula (I-2), L1 represents the following groups:

[0550] ##-CH2-O-CH2-, ##-CH2-O-(CH2)2-, ##-(CH2)1-O-(CH2)3-, ##-(CH2)1-O-(CH2)4-, ##-(CH2)1-O-(CH2)5-, ##- (CH2)1-O-(CH2)6-, ##-(CH2)1-O-(CH2)7-, ##-(CH2)1-O-(CH2)8-, ##-(CH2)1-O-(CH2)9-, ##-(CH2)1-O-(CH2) 10-, ##-(CH2)2-O-(CH2)1-, ##-(CH2)2-O-(CH2)2-, ##-(CH2)2-O-(CH2)3-, ##-(CH2)2-O-(CH2)4-, ##-(CH2)2-O-(CH2)5-, ##-(CH2)2-O-(CH2)6-, ##-(CH2)2-O-(CH2)7-, ##-(CH2)2-O-(CH2)8-, ##-(CH2)2-O-(CH2)9-, ##-(CH2)2-O-(CH2) 10 -##-(CH2)2-O-(CH2) 11 -##-(CH2)2-O-(CH2) 12-##-(CH2)3-O-(CH2)1-##-(CH2)3-O-(CH2)2-##-(CH2)3-O-(CH2)3-##-(CH2)3-O-(CH2)4-##-(CH2)3-O-(CH2)5-##-(CH2)3-O-(CH2)6-##-(CH2)3-O-(CH2)7-##-(CH2)4-O-(CH2)1-##-(CH2)4-O-(CH2)2-##-(C H2)4-O-(CH2)3-、##-(CH2)4-O-(CH2)4-、##-(CH2)4-O-(CH2)5-、##-(CH2)4-O-(CH2)6-、##-(CH2)5-O-(CH2)1 -、##-(CH2)5-O-(CH2)2-、##-(CH2)5-O-(CH2)3-、##-(CH2)5-O-(CH2)4-、##-(CH2)5-O-(CH2)5-、##-(CH2)6-O- (CH2)1-, ##-(CH2)6-O-(CH2)2-, ##-(CH2)6-O-(CH2)3-, ##-(CH2)6-O-(CH2)4-, ##-(CH2)7-O-(CH2)1-, ##-(CH2)7-O-(CH2)2-, ##-(CH2)7-O-(CH2)3-, ##-(CH2)8-O-(CH2)1-, ##-(CH2)8-O-(CH2)2-, ##-CH(CH3)-O-(CH2)1 -, ##-CH(CH3)-O-(CH2)2-, ##-CH(CH3)-O-(CH2)3-, ##-CH(CH3)-O-(CH2)4-, ##-CH(CH3)-O-(CH2)5-, ##-CH(CH3)-O-(CH2)6-, ##-CH(CH3)-O-(CH2)7-, ##-CH(CH3)-O-(CH2)8-, ##-CH(CH3)-O-(CH2)9-, ##-CH(CH3)-O-(CH2) 10 -, ##-CH2-(O(CH2)2)2-, ##-CH2-(O(CH2)2)3-, ##-CH2-(O(CH2)2)4-, ##-CH2-(O(CH2)2)5-, ##-CH2-(O(CH2)2)6-, ##-CH2-(O(CH2)2)7-, ##-CH2-(O(CH2)2)8-, ##-CH2-(O(CH2)2)9-, ##-CH2-(O(CH2)2) 10-、##-CH2-(O(CH2)2)1-OCH2-、##-CH2-(O(CH2)2)2-OCH2-、##-CH2-(O(CH2)2)3-OCH2-、##-CH2-(O(CH2)2)4-OCH2-、##-CH2-(O(CH2)2)5-OCH2-、##-CH2-(O(CH2)2)6-OCH2-、##-CH2-(O(CH2)2)7-OCH2-、##-CH2-(O(CH2)2)8-OCH2-、##-CH2-(O(CH2)2)9-OCH2-、##-CH2-(O(CH2)2) 10 -OCH2-、##-(CH2)2-(O(CH2)2)2-、##-(CH2)2-(O(CH2)2)3-、##-(CH2)2-(O(CH2)2)4-、##-(CH2)2-(O(CH2)2)5-、##-(CH2)2-(O(CH2)2)6-、##-(CH2)2-(O(CH2)2)7-、##-(CH2)2-(O(CH2)2)8-、##-(CH2)2-(O(CH2)2)9-、##-(CH2)2-(O(CH2)2) 10 -、##-(CH2)3-(O(CH2)2)2-、##-(CH2)3-(O(CH2)2)3-、##-(CH2)3-(O(CH2)2)4-、##-(CH2)3-(O(CH2)2)5-、##-(CH2)3-(O(CH2)2)6-、##-(CH2)3-(O(CH2)2)7-、##-(CH2)3-(O(CH2)2)8-、##-(CH2)3-(O(CH2)2)9-、##-(CH2)3-(O(CH2)2) 10 -、##-(CH2)4-(O(CH2)2)2-、##-(CH2)4-(O(CH2)2)3-、##-(CH2)4-(O(CH2)2)4-、##-(CH2)4-(O(CH2)2)5-、##-(CH2)4-(O(CH2)2)6-、##-(CH2)4-(O(CH2)2)7-、##-(CH2)4-(O(CH2)2)8-、##-(CH2)4-(O(CH2)2)9-、##-(CH2)4-(O(CH2)2) 10-, ##-CH2-(O(CH2)3)2-, ##-CH2-(O(CH2)3)3-, ##-CH2-(O(CH2)3)4-, ##-CH2-(O(CH2)3)5-, ##-CH2-(O(CH2)3)6-, ##-CH2-(O(CH2)3)7-, ##-CH2-(O(CH2)3)8-, ##-CH2-(O(CH2)3)9-, ##-CH2-(O(CH2)3) 10 -, ##-(CH2)2-(O(CH2)3)2-, ##-(CH2)2-(O(CH2)3)3-, ##-(CH2)2-(O(CH2)3)4-, ##-(CH2)2-(O(CH2)3)5-, ##-(CH2)2-(O(CH2)3)6-, ##-(CH2)2-(O(CH2)3)7-, ##-(CH2)2-(O(CH2)3)8-, ##-(CH2)2-(O(CH2)3)9-, ##-(CH2)2-(O(CH2)3) 10 -, ##-(CH2)3-(O(CH2)3)2-, ##-(CH2)3-(O(CH2)3)3-, ##-(CH2)3-(O(CH2)3)4-, ##-(CH2)3-(O(CH2)3)5-, ##-(CH2)3-(O(CH2)3)6-, ##-(CH2)3-(O(CH2)3)7-, ##-(CH2)3-(O(CH2)3)8-, ##-(CH2)3-(O(CH2)3)9-, ##-(CH2)3-(O(CH2)3) 10-##-CH2-O-(CH2)2-O-(CH2)3-##-CH2-(O(CH2)2)2-(O(CH2)3)2-##-CH2-(O(CH2)2)3-(O(CH2)3)3-##-CH2-(O(CH2)2)4-(O(CH2)3)4-##-CH2-(O(CH2)2)5-(O(CH2)3)5-##-CH2-(O(CH2)2)6-(O(CH2)3)6-##-(CH2)2-O-(CH2)2-O-(CH2)3-##-(CH2)3-##-(CH2)2 -(O(CH2)2)3-(O(CH2)3)3-、##-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-、##-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-、##-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-、##-(CH2)3-O-(CH2)2-O-(CH2)3-、##-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-、##-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-、##-(CH2)3-(O(CH2)2)4-(O(CH2)3)4- 、##-(CH2)3-(O(CH2)2)5-(O(CH2)3)5-、##-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-、##-CH2-O-(CH2)3-O-(CH2)2-、##-CH2-(O(CH2)3)2-(O(CH2)2)2-、##-CH2-(O(CH2)3)3-(O(CH2)2)3-、##-CH2-(O(CH2)3)4-(O(CH2)2)4-、##-CH2-(O(CH2)3)5-(O(CH2)2)5-、##-CH2-(O(CH2)3)6-(O(CH2)2)6-、##-(CH 2)2-O-(CH2)3-O-(CH2)2-,##-(CH2)2-(O(CH2)3)2-(O(CH2)2)2-,##-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-,##-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-,##-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-,##-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-,##-(CH2)3-O-(CH2)3-O-(CH2)2-,##-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-,##-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-、##-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-、##-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-、##-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-、##-CH2 -O-(CH2)2-O-CH2-,##-(CH2)2-O-(CH2)2-O-CH2-,##-(CH2)2-(O(CH2)2)2-O-(CH2)3-,##-(CH2)2-(O(CH2)2)3-O-(CH2)3-,##-(CH2)2-(O(CH2)2)4-O-(CH2)3-,##- (CH2)5-(O(CH2)2)2-O-(CH2)5-, ##-(CH2)5-(O(CH2)2)2-O-(CH2)6-, ##-CH2-C(O)-CH2-, ##-CH2-C(O)-(CH2)2-, ##-(CH2)1-C(O)-(CH2)3-, ##-(CH2)1-C(O)-(CH2) 4-, ##-(CH2)1-C(O)-(CH2)5-, ##-(CH2)1-C(O)-(CH2)6-, ##-(CH2)1-C(O)-(CH2)7-, ##-(CH2)1-C(O)-(CH2)8-, ##-(CH2)1-C(O)-(CH2)9-, ##-(CH2)1-C(O)-(CH2) 10 -, ##-(CH2)2-C(O)-(CH2)1-, ##-(CH2)2-C(O)-(CH2)2-, ##-(CH2)2-C(O)-(CH2)3-, ##-(CH2)2-C(O)-(CH2)4-, ##-(CH2)2-C(O)-(CH2)5-, ##-(CH2)2-C(O)-(CH2)6-, ##-(CH2)2-C(O)-(CH2)7-, ##-(CH2)2-C(O)-(CH2)8-, ##-(CH2)2-C(O)-(CH2)9-, ##-(CH2)2-C(O)-(CH2) 10 -##-(CH2)2-C(O)-(CH2) 11 -##-(CH2)2-C(O)-(CH2) 12-、##-(CH2)3-C(O)-(CH2)1-、##-(CH2)3-C(O)-(CH2)2-、##-(CH2)3-C(O)-(CH2)3-、##-(CH2)3-C(O)-(CH2)4-、##-(CH2)3-C(O)-(CH2)5-、##-(CH2)3-C(O)-(CH2)6-、##-(CH2)3-C(O)-(CH2)7-、##-(CH2)4-C(O)-(CH2)1-、##-(CH2)4-C(O)-(CH2)2-、##-(CH2)4-C(O)-(CH2)3-、##-(CH2)4-C(O)-(CH2)4-、##-(CH2)4-C(O)-(CH2)5-、##-(CH2)4-C(O)-(CH2)6-、##-(CH2)5-C(O)-(CH2)1-、##-(CH2)5-C(O)-(CH2)2-、##-(CH2)5-C(O)-(CH2)3-、##-(CH2)5-C(O)-(CH2)4-、##-(CH2)5-C(O)-(CH2)5-、##-(CH2)6-C(O)-(CH2)1-、##-(CH2)6-C(O)-(CH2)2-、##-(CH2)6-C(O)-(CH2)3-、##-(CH2)6-C(O)-(CH2)4-、##-(CH2)7-C(O)-(CH2)1-、##-(CH2)7-C(O)-(CH2)2-、##-(CH2)7-C(O)-(CH2)3-、##-(CH2)8-C(O)-(CH2)1-、##-(CH2)8-C(O)-(CH2)2-、##-CH2-S-CH2-、##-CH2-S-(CH2)2-、##-(CH2)1-S-(CH2)3-、##-(CH2)1-S-(CH2)4-、##-(CH2)1-S-(CH2)5-、##-(CH2)1-S-(CH2)6-、##-(CH2)1-S-(CH2)7-、##-(CH2)1-S-(CH2)8-、##-(CH2)1-S-(CH2)9-、##-(CH2)1-S-(CH2) 10-、##-(CH2)2-S-(CH2)1-、##-(CH2)2-S-(CH2)2-、##-(CH2)2-S-(CH2)3-、##-(CH2)2-S-(CH2)4-、##-(CH2)2-S-(CH2)5-、##-(CH2)2-S-(CH2)6-、##-(CH2)2-S-(CH2)7-、##-(CH2)2-S-(CH2)8-、##-(CH2)2-S-(CH2)9-、##-(CH2)2-S-(CH2) 10 -、##-(CH2)2-S-(CH2) 11 -、##-(CH2)2-S-(CH2) 12-、##-(CH2)3-S-(CH2)1-、##-(CH2)3-S-(CH2)2-、##-(CH2)3-S-(CH2)3-、##-(CH2)3-S-(CH2)4-、##-(CH2)3-S-(CH2)5-、##-(CH2)3-S-(CH2)6-、##-(CH2)3-S-(CH2)7-、##-(CH2)4-S-(CH2)1-、##-(CH2)4-S-(CH2)2-、##-(CH2)4-S-(CH2)3-、##-(CH2)4-S-(CH2)4-、##-(CH2)4-S-(CH2)5-、##-(CH2)4-S-(CH2)6-、##-(CH2)5-S-(CH2)1-、##-(CH2)5-S-(CH2)2-、##-(CH2)5-S-(CH2)3-、##-(CH2)5-S-(CH2)4-、##-(CH2)5-S-(CH2)5-、##-(CH2)6-S-(CH2)1-、##-(CH2)6-S-(CH2)2-、##-(CH2)6-S-(CH2)3-、##-(CH2)6-S-(CH2)4-、##-(CH2)7-S-(CH2)1-、##-(CH2)7-S-(CH2)2-、##-(CH2)7-S-(CH2)3-、##-(CH2)8-S-(CH2)1-、##-(CH2)8-S-(CH2)2-、##-CH2-C(S)-CH2-、##-CH2-C(S)-(CH2)2-、##-(CH2)1-C(S)-(CH2)3-、##-(CH2)1-C(S)-(CH2)4-、##-(CH2)1-C(S)-(CH2)5-、##-(CH2)1-C(S)-(CH2)6-、##-(CH2)1-C(S)-(CH2)7-、##-(CH2)1-C(S)-(CH2)8-、##-(CH2)1-C(S)-(CH2)9-、##-(CH2)1-C(S)-(CH2) 10-、##-(CH2)2-C(S)-(CH2)1-、##-(CH2)2-C(S)-(CH2)2-、##-(CH2)2-C(S)-(CH2)3-、##-(CH2)2-C(S)-(CH2)4-、##-(CH2)2-C(S)-(CH2)5-、##-(CH2)2-C(S)-(CH2)6-、##-(CH2)2-C(S)-(CH2)7-、##-(CH2)2-C(S)-(CH2)8-、##-(CH2)2-C(S)-(CH2)9-、##-(CH2)2-C(S)-(CH2) 10 -、##-(CH2)2-C(S)-(CH2) 11 -、##-(CH2)2-C(S)-(CH2) 12-、##-(CH2)3-C(S)-(CH2)1-、##-(CH2)3-C(S)-(CH2)2-、##-(CH2)3-C(S)-(CH2)3-、##-(CH2)3-C(S)-(CH2)4-、##-(CH2)3-C(S)-(CH2)5-、##-(CH2)3-C(S)-(CH2)6-、##-(CH2)3-C(S)-(CH2)7-、##-(CH2)4-C(S)-(CH2)1-、##-(CH2)4-C(S)-(CH2)2-、##-(CH2)4-C(S)-(CH2)3-、##-(CH2)4-C(S)-(CH2)4-、##-(CH2)4-C(S)-(CH2)5-、##-(CH2)4-C(S)-(CH2)6-、##-(CH2)5-C(S)-(CH2)1-、##-(CH2)5-C(S)-(CH2)2-、##-(CH2)5-C(S)-(CH2)3-、##-(CH2)5-C(S)-(CH2)4-、##-(CH2)5-C(S)-(CH2)5-、##-(CH2)6-C(S)-(CH2)1-、##-(CH2)6-C(S)-(CH2)2-、##-(CH2)6-C(S)-(CH2)3-、##-(CH2)6-C(S)-(CH2)4-、##-(CH2)7-C(S)-(CH2)1-、##-(CH2)7-C(S)-(CH2)2-、##-(CH2)7-C(S)-(CH2)3-、##-(CH2)8-C(S)-(CH2)1-、##-(CH2)8-C(S)-(CH2)2-、##-CH2-C(O)O-CH2-、##-CH2-C(O)O-(CH2)2-、##-(CH2)1-C(O)O-(CH2)3-、##-(CH2)1-C(O)O-(CH2)4-、##-(CH2)1-C(O)O-(CH2)5-、##-(CH2)1-C(O)O-(CH2)6-、##-(CH2)1-C(O)O-(CH2)7-、##-(CH2)1-C(O)O-(CH2)8-、##-(CH2)1-C(O)O-(CH2)9-、##-(CH2)1-C(O)O-(CH2) 10-, ##-(CH2)2-C(O)O-(CH2)1-, ##-(CH2)2-C(O)O-(CH2)2-, ##-(CH2)2-C(O)O-(CH2)3-, ##-(CH2)2-C(O)O-(CH2)4-, ##-(CH2)2-C(O)O-(CH2)5-, ##-(CH2)2-C(O)O-(CH2)6-, ##-(CH2)2-C(O)O-(CH2)7-, ##-(CH2)2-C(O)O-(CH2)8-, ##-(CH2)2-C(O)O-(CH2)9-, ##-(CH2)2-C(O)O-(CH2) 10 -##-(CH2)2-C(O)O-(CH2) 11 -##-(CH2)2-C(O)O-(CH2) 12-, ##-(CH2)3-C(O)O-(CH2)1-, ##-(CH2)3-C(O)O-(CH2)2-, ##-(CH2)3-C(O)O-(CH2)3-, ##-(CH2)3-C(O)O-(CH2)4-, ##-(CH2)3-C(O)O-(CH2)5-, ##-(CH2)3-C(O)O-(CH2)6-, ##-(CH2)3-C(O)O-(CH2)7-, ##-(CH2)4-C(O)O-(CH2)1-, ##-(CH2)4-C(O)O-(CH2)2-, # #-(CH2)4-C(O)O-(CH2)3-, ##-(CH2)4-C(O)O-(CH2)4-, ##-(CH2)4-C(O)O-(CH2)5-, ##-(CH2)4-C(O)O-(CH2)6-, ##-(CH2)5-C(O)O-(CH2)1-, ##-(CH2)5-C(O)O-(CH2)2-, ##-(CH2)5-C(O)O-(CH2)3-, ##-(CH2)5-C(O)O-(CH2)4-, ##-(CH2)5-C(O)O-(CH2)5-, ##-(C H2)6-C(O)O-(CH2)1-, ##-(CH2)6-C(O)O-(CH2)2-, ##-(CH2)6-C(O)O-(CH2)3-, ##-(CH2)6-C(O)O-(CH2)4-, ##-(CH2)7-C(O)O-(CH2)1-, ##-(CH2)7-C(O)O-(CH2)2-, ##-(CH2)7-C(O)O-(CH2)3-, ##-(CH2)8-C(O)O-(CH2)1-, ##-(CH2)8-C(O)O-(CH2)2-, ##-CH2-O C(O)-CH2-、##-CH2-OC(O)-(CH2)2-、##-(CH2)1-OC(O)-(CH2)3-、##-(CH2)1-OC(O)-(CH2)4-、##-(CH2)1-OC(O)-(CH2)5-、##-(CH2 )1-OC(O)-(CH2)6-、##-(CH2)1-OC(O)-(CH2)7-、##-(CH2)1-OC(O)-(CH2)8-、##-(CH2)1-OC(O)-(CH2)9-、##-(CH2)1-OC(O)-(CH2) 10-、##-(CH2)2-OC(O)-(CH2)1-、##-(CH2)2-OC(O)-(CH2)2-、##-(CH2)2-OC(O)-(CH2)3-、##-(CH2)2-OC(O)-(CH2)4-、##-(CH2)2-OC(O)-(CH2)5-、##-(CH2)2-OC(O)-(CH2)6-、##-(CH2)2-OC(O)-(CH2)7-、##-(CH2)2-OC(O)-(CH2)8-、##-(CH2)2-OC(O)-(CH2)9-、##-(CH2)2-OC(O)-(CH2) 10 -、##-(CH2)2-OC(O)-(CH2) 11 -、##-(CH2)2-OC(O)-(CH2) 12 -、##-(CH2)3-OC(O)-(CH2)1-、##-(CH2)3-OC(O)-(CH2)2-、##-(CH2)3-OC(O)-(CH2)3-、##-(CH2)3-OC(O)-(CH2)4-、##-(CH2)3-OC(O)-(CH2)5-、##-(CH2)3-OC(O)-(CH2)6-、##-(CH2)3-OC(O)-(CH2)7-、##-(CH2)4-OC(O)-(CH2)1-、##-(CH2)4-OC(O)-(CH2)2-、##-(CH2)4-OC(O)-(CH2)3-、##-(CH2)4-OC(O)-(CH2)4-、##-(CH2)4-OC(O)-(CH2)5-、##-(CH2)4-OC(O)-(CH2)6-、##-(CH2)5-OC(O)-(CH2)1-、##-(CH2)5-OC(O)-(CH2)2-、##-(CH2)5-OC(O)-(CH2)3-、##-(CH2)5-OC(O)-(CH2)4-、##-(CH2)5-OC(O)-(CH2)5-、##-(CH2)6-OC(O)-(CH2)1-、##-(CH2)6-OC(O)-(CH2)2-、##-(CH2)6-OC(O)-(CH2)3-、##-(CH2)6-OC(O)-(CH2)4-、##-(CH2)7-OC(O)-(CH2)1-、##-(CH2)7-OC(O)-(CH2)2-、##-(CH2)7-OC(O)-(CH2)3-、##-(CH2)8-OC(O)-(CH2)1-、##-(CH2)8-OC(O)-(CH2)2-、##-(CH2)1-N(R g10)-(CH2)1-、##-(CH2)1-N(R g10 )-(CH2)2-、##-(CH2)1-N(R g10 )-(CH2)3-、##-(CH2)1-N(R g10 )-(CH2)4-、##-(CH2)1-N(R g10 )-(CH2)5-、##-(CH2)1-N(R g10 )-(CH2)6-、##-(CH2)1-N(R g10 )-(CH2)7-、##-(CH2)1-N(R g10 )-(CH2)8-、##-(CH2)1-N(R g10 )-(CH2)9-、##-(CH2)1-N(R g10 )-(CH2) 10 -、##-(CH2)2-N(R g10 )-(CH2)1-、##-(CH2)2-N(R g10 )-(CH2)2-、##-(CH2)2-N(R g10 )-(CH2)3-、##-(CH2)2-N(R g10 )-(CH2)4-、##-(CH2)2-N(R g10 )-(CH2)5-、##-(CH2)2-N(R g10 )-(CH2)6-、##-(CH2)2-N(R g10 )-(CH2)7-、##-(CH2)2-N(R g10 )-(CH2)8-、##-(CH2)2-N(R g10 )-(CH2)9-、##-(CH2)2-N(R g10 )-(CH2) 10 -、##-(CH2)2-N(R g10 )-(CH2) 11 -、##-(CH2)2-N(R g10 )-(CH2) 12 -、##-(CH2)3-N(R g10 )-(CH2)1-、##-(CH2)3-N(R g10 )-(CH2)2-、##-(CH2)3-N(R g10 )-(CH2)3-、##-(CH2)4-N(R g10 )-(CH2)1-、##-(CH2)4-N(R g10)-(CH2)2-、##-(CH2)4-N(R g10 )-(CH2)3-、##-(CH2)4-N(R g10 )-(CH2)4-、##-(CH2)5-N(R g10 )-(CH2)1-、##-(CH2)5-N(R g10 )-(CH2)2-、##-(CH2)5-N(R g10 )-(CH2)3-、##-(CH2)5-N(R g10 )-(CH2)4-、##-(CH2)5-N(R g10 )-(CH2)5-、##-(CH2)6-N(R g10 )-(CH2)1-、##-(CH2)6-N(R g10 )-(CH2)2-、##-(CH2)6-N(R g10 )-(CH2)3-、##-(CH2)7-N(R g10 )-(CH2)1-、##-(CH2)7-N(R g10 )-(CH2)2-、##-(CH2)7-N(R g10 )-(CH2)3-、##-(CH2)8-N(R g10 )-(CH2)1-、##-(CH2)8-NR g10 )-(CH2)2-、##-(CH2)8-N(R g10 )-(CH2)3-、##-CH(CH3)-N(R g10 )-(CH2)1-、##-CH(CH3)-N(R g10 )-(CH2)2-、##-CH(CH3)-N(R g10 )-(CH2)3-、##-CH(CH3)-N(R g10 )-(CH2)4-、##-CH(CH3)-N(R g10 )-(CH2)5-、##-CH(CH3)-N(R g10 )-(CH2)6-、##-CH(CH3)-N(R g10 )-(CH2)7-、##-CH(CH3)-N(R g10 )-(CH2)8-、##-CH(CH3)-N(R g10 )-(CH2)9-、##-CH(CH3)-N(R g10 )-(CH2) 10-##-CH2C(O)NHCH2-##-(CH2)2C(O)NH(CH2)2-##-(CH2)2C(O)NH(CH2)3-##-(CH2)2C(O)NH(CH2)4-##-(CH2)2C(O)NH(CH2)5-##-(CH2)3C(O)NH(CH2)3-##-(CH2)3C(O)NH(CH2)4-##-(C H2)4C(O)NH(CH2)4-,##-(CH2)5C(O)NH(CH2)5-,##-(CH2)6C(O)NH(CH2)7-,##-(CH2)6C(O)NH(CH2)6-,##-(CH2)7C(O)NH(CH2)7-,##-(CH2)8C(O)NH(CH2)8,##-(CH2)9C(O)NH(CH2)9-,##-(CH2) 10 C(O)NH(CH2) 10 -、##-(CH2)2C(O)NH(CH2)2-O-(CH2)2-、##-CH2NHC(O)CH2-、##-(CH2)2NHC(O)(CH2)2-、##-(CH2)2NHC(O) (CH2)3-、##-(CH2)2NHC(O)(CH2)4-、##-(CH2)2NHC(O)(CH2)5-、##-(CH2)3NHC(O)(CH2)3-、##-(CH2)3NHC (O)(CH2)4-、##-(CH2)4NHC(O)(CH2)4-、##-(CH2)5NHC(O)(CH2)5-、##-(CH2)6NHC(O)(CH2)7-、##-(CH2)6 NHC(O)(CH2)6-、##-(CH2)7NHC(O)(CH2)7-、##-(CH2)8NHC(O)(CH2)8、##-(CH2)9NHC(O)(CH2)9-、##-(CH2) 10 NHC(O)(CH2) 10-、##-(CH2)4NHC(O)(CH2)8-、##-(CH2)2NHC(O)(CH2)2-O-(CH2)2-、##-(CH2)4NHC(O)CH2-、##-CH2-piperidinyl-CH2-、##-CH2-piperidinyl-(CH2)2-、##-CH2-piperidinyl-(CH2)3-、##-CH2-piperidinyl-(CH2)4-、##-CH2-piperidinyl-(CH2)5-、##-CH2-piperidinyl-(CH2)6-、##-CH2-piperidinyl-(CH2)7-、##-CH2-piperidinyl-(CH2)8-、##-(CH2)2-piperidinyl- Pyridyl-(CH2)1-, ##-(CH2)2-piperidinyl-(CH2)2-, ##-(CH2)2-piperidinyl-(CH2)3-, ##-(CH2)2-piperidinyl-(CH2)4-, ##-(CH2)2-piperidinyl-(CH2)5-, ##-(CH2)2-piperidinyl-(CH2)6-, ##-(CH2)2-piperidinyl-(CH2)7-, ##-(CH2)2-piperidinyl-(CH2)8-, ##-(CH2)3-piperidinyl-CH2-, ##-(CH2)3-piperidinyl-(CH2)2-, ##-(CH2)3-piperidinyl-(CH2)3-, ##-(CH2)3 -piperidinyl-(CH2)4-, ##-(CH2)3-piperidinyl-(CH2)5-, ##-(CH2)3-piperidinyl-(CH2)6-, ##-(CH2)3-piperidinyl-(CH2)7-, ##-(CH2)3-piperidinyl-(CH2)8-, ##-(CH2)4-piperidinyl-CH2-, ##-(CH2)4-piperidinyl-(CH2)2-, ##-(CH2)4-piperidinyl-(CH2)3-, ##-(CH2)4-piperidinyl-(CH2)4-, ##-(CH2)4-piperidinyl-(CH2)5-, ##-(CH2)4-piperidinyl-(CH2)6-, ##-(CH2)4-piperidinyl-(CH2)6-, ##-(CH2)4-piperidinyl-(CH2)4-, ##-(CH2)4-piperidinyl-(CH2)5-, ##-(CH2)4-piperidinyl-(CH2)6 ... 2) 4-Piperidinyl-(CH2)7-, ##-(CH2)4-piperidinyl-(CH2)8-, ##-(CH2)5-piperidinyl-(CH2)1-, ##-(CH2)5-piperidinyl-(CH2)2-, ##-(CH2)5-piperidinyl-(CH2)3-, ##-(CH2)5-piperidinyl-(CH2)4-, ##-(CH2)5-piperidinyl-(CH2)5-, ##-(CH2)5-piperidinyl-(CH2)6-, ##-(CH2)5-piperidinyl-(CH2)7-, ##-(CH2)5-piperidinyl-(CH2)8-, ##-(CH2)6-piperidinyl-(CH2)1-,##-(CH2)6-piperidinyl-(CH2)2-, ##-(CH2)6-piperidinyl-(CH2)3-, ##-(CH2)6-piperidinyl-(CH2)4-, ##-(CH2)6-piperidinyl-(CH2)5-, ##-(CH2)6-piperidinyl-(CH2)6-, ##-(CH2)6-piperidinyl-(CH2)7-, ##-(CH2)6-piperidinyl-(CH2)8-, ##-(CH2)7-piperidinyl-(CH2)1-, ##-(CH2)7-piperidinyl-(CH2)2-, ##-(CH2)7-piperidinyl-(CH2)3-, ##-(CH2)7-piperidinyl-(CH2) )4-、##-(CH2)7-piperidinyl-(CH2)8-、##-(CH2)8-piperidinyl-CH2-、##-(CH2)8-piperidinyl-(CH2)2-、##-(CH2)8-piperidinyl-(CH2)3-、##-(CH2)8-piperidinyl-(CH2)4-、##-(CH2)8-piperidinyl-(CH2)5-、##-(CH2)8-piperidinyl-(CH2)6-、##-(CH2)8-piperidinyl-(CH2)7-、##-(CH2)8-piperidinyl-(CH2)8-、##-CH2-piperazinyl-CH2-、##-CH2-piperazinyl-(CH2)2-、##-CH 2-Piperazinyl-(CH2)3-, ##-CH2-piperazinyl-(CH2)4-, ##-CH2-piperazinyl-(CH2)5-, ##-CH2-piperazinyl-(CH2)6-, ##-CH2-piperazinyl-(CH2)7-, ##-CH2-piperazinyl-(CH2)8-, ##-(CH2)2-piperazinyl-(CH2)1-, ##-(CH2)2-piperazinyl-(CH2)2-, ##-(CH2)2-piperazinyl-(CH2)3-, ##-(CH2)2-piperazinyl-(CH2)4-, ##-(CH2)2-piperazinyl-(CH2)5-, ##-(CH2)2-piperazinyl-(CH2) 6-、##-(CH2)2-piperazinyl-(CH2)7-、##-(CH2)2-piperazinyl-(CH2)8-、##-(CH2)3-piperazinyl-CH2-、##-(CH2)3-piperazinyl-(CH2)2-、##-(CH2)3-piperazinyl-(CH2)3-、##-(CH2)3-piperazinyl-(CH2)4-、##-(CH2)3-piperazinyl-(CH2)5-、##-(CH2)3-piperazinyl-(CH2)6-、##-(CH2)3-piperazinyl-(CH2)7-、##-(CH2)3-piperazinyl-(CH2)8-、##-(CH2)4-piperazinyl-CH2-、##-(CH2)4-piperazinyl-(CH2)2-, ##-(CH2)4-piperazinyl-(CH2)3-, ##-(CH2)4-piperazinyl-(CH2)4-, ##-(CH2)4-piperazinyl-(CH2)5-, ##-(CH2)4-piperazinyl-(CH2)6-, ##-(CH2)4-piperazinyl-(CH2)7-, ##-(CH2)4-piperazinyl-(CH2)8-, ##-(CH2)5-piperazinyl-(CH2)1-, ##-(CH2)5-piperazinyl-(CH2)2-, ##-(CH2)5-piperazinyl-(CH2)3-, ##-(CH2)5-piperazinyl-(CH2) )4-、##-(CH2)5-piperazinyl-(CH2)5-、##-(CH2)5-piperazinyl-(CH2)6-、##-(CH2)5-piperazinyl-(CH2)7-、##-(CH2)5-piperazinyl-(CH2)8-、##-(CH2)6-piperazinyl-(CH2)1-、##-(CH2)6-piperazinyl-(CH2)2-、##-(CH2)6-piperazinyl-(CH2)3-、##-(CH2)6-piperazinyl-(CH2)4-、##-(CH2)6-piperazinyl-(CH2)5-、##-(CH2)6-piperazinyl-(CH2)6-、##-(CH2)6-piperazinyl- (CH2)7-, ##-(CH2)6-piperazinyl-(CH2)8-, ##-(CH2)7-piperazinyl-(CH2)1-, ##-(CH2)7-piperazinyl-(CH2)2-, ##-(CH2)7-piperazinyl-(CH2)3-, ##-(CH2)7-piperazinyl-(CH2)4-, ##-(CH2)7-piperazinyl-(CH2)8-, ##-(CH2)8-piperazinyl-CH2-, ##-(CH2)8-piperazinyl-(CH2)2-, ##-(CH2)8-piperazinyl-(CH2)3-, ##-(CH2)8-piperazinyl-(CH2)4-, ##-(CH2)8-piperazinyl -(CH2)5-, ##-(CH2)8-piperazinyl-(CH2)6-, ##-(CH2)8-piperazinyl-(CH2)7-, ##-(CH2)8-piperazinyl-(CH2)8-, ##-CH2-propylidene-CH2-, ##-CH2-propylidene-(CH2)2-, ##-CH2-propylidene-(CH2)3-, ##-CH2-propylidene-(CH2)4-, ##-CH2-propylidene-(CH2)5-, ##-CH2-propylidene-(CH2)6-, ##-CH2-propylidene-(CH2)7-, ##-CH2-propylidene-(CH2)8-, ##-(CH2)2-propylidene-(CH2)1-##-(CH2)2-propylidene-(CH2)2-, ##-(CH2)2-propylidene-(CH2)3-, ##-(CH2)2-propylidene-(CH2)4-, ##-(CH2)2-propylidene-(CH2)5-, ##-(CH2)2-propylidene-(CH2)6-, ##-(CH2)2-propylidene-(CH2)7-, ##-(CH2)2-propylidene-(CH2)8-, ##-(CH2)3-propylidene-CH2-, ##-(CH2)3-propylidene-(CH2)2-, ##-(CH2)3-propylidene-(CH2)3-, ##-(CH2)3-propylidene-(CH2)4-, ##-(CH 2) 3-Propylene-(CH2)5-, ##-(CH2)3-Propylene-(CH2)6-, ##-(CH2)3-Propylene-(CH2)7-, ##-(CH2)3-Propylene-(CH2)8-, ##-(CH2)4-Propylene-CH2-, ##-(CH2)4-Propylene-(CH2)2-, ##-(CH2)4-Propylene-(CH2)3-, ##-(CH2)4-Propylene-(CH2)4-, ##-(CH2)4-Propylene-(CH2)5-, ##-(CH2)4-Propylene-(CH2)6-, ##-(CH2)4-Propylene-(CH2)7-, ##-(CH2)4-Propylene propyl-(CH2)8-, ##-(CH2)5-propylidene-(CH2)1-, ##-(CH2)5-propylidene-(CH2)2-, ##-(CH2)5-propylidene-(CH2)3-, ##-(CH2)5-propylidene-(CH2)4-, ##-(CH2)5-propylidene-(CH2)5-, ##-(CH2)5-propylidene-(CH2)6-, ##-(CH2)5-propylidene-(CH2)7-, ##-(CH2)5-propylidene-(CH2)8-, ##-(CH2)6-propylidene-(CH2)1-, ##-(CH2)6-propylidene-(CH2)2-, ##-(CH2)6-propylidene-( CH2)3-, ##-(CH2)6-propylidene-(CH2)4-, ##-(CH2)6-propylidene-(CH2)5-, ##-(CH2)6-propylidene-(CH2)6-, ##-(CH2)6-propylidene-(CH2)7-, ##-(CH2)6-propylidene-(CH2)8-, ##-(CH2)7-propylidene-(CH2)1-, ##-(CH2)7-propylidene-(CH2)2-, ##-(CH2)7-propylidene-(CH2)3-, ##-(CH2)7-propylidene-(CH2)4-, ##-(CH2)7-propylidene-(CH2)8-, ##-(CH2)8-propylidene-CH2-,##-(CH2)8-Propylene-(CH2)2-, ##-(CH2)8-Propylene-(CH2)3-, ##-(CH2)8-Propylene-(CH2)4-, ##-(CH2)8-Propylene-(CH2)5-, ##-(CH2)8-Propylene-(CH2)6-, ##-(CH2)8-Propylene-(CH2)7-, ##-(CH2)8-Propylene-(CH2)8-, ##-CH2-Diazacycloheptane-CH2-, ##-CH2-Diazacycloheptane-(CH2)2-, ##-CH2-Diazacycloheptane-(CH2)3-, ##-CH2-Diazacycloheptane-(CH2)4- ##-CH2-diazacyclic heptanediyl-(CH2)5-, ##-CH2-diazacyclic heptanediyl-(CH2)6-, ##-CH2-diazacyclic heptanediyl-(CH2)7-, ##-CH2-diazacyclic heptanediyl-(CH2)8-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)1-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)2-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)3-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)4-, ##-(CH2)2-diazacyclic heptanediyl-(CH2)5-, ##-(CH2)2-diazacyclic Heptane-(CH2)6-, ##-(CH2)2-diazacyclic heptane-(CH2)7-, ##-(CH2)2-diazacyclic heptane-(CH2)8-, ##-(CH2)3-diazacyclic heptane-CH2-, ##-(CH2)3-diazacyclic heptane-(CH2)2-, ##-(CH2)3-diazacyclic heptane-(CH2)3-, ##-(CH2)3-diazacyclic heptane-(CH2)4-, ##-(CH2)3-diazacyclic heptane-(CH2)5-, ##-(CH2)3-diazacyclic heptane-(CH2)6-, ##-(CH2)3-diazacyclic heptane-( CH2)7-, ##-(CH2)3-diazacyclic heptane-(CH2)8-, ##-(CH2)4-diazacyclic heptane-CH2-, ##-(CH2)4-diazacyclic heptane-(CH2)2-, ##-(CH2)4-diazacyclic heptane-(CH2)3-, ##-(CH2)4-diazacyclic heptane-(CH2)4-, ##-(CH2)4-diazacyclic heptane-(CH2)5-, ##-(CH2)4-diazacyclic heptane-(CH2)6-, ##-(CH2)4-diazacyclic heptane-(CH2)7-, ##-(CH2)4-diazacyclic heptane-(CH2)8-##-(CH2)5-diazacyclic heptanediyl-(CH2)1-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)2-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)3-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)4-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)5-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)6-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)7-, ##-(CH2)5-diazacyclic heptanediyl-(CH2)8-, ##-(CH2)6-diazacyclic heptanediyl-(CH2)1-, ##-(CH2) 6-diazacyclic heptanediol-(CH2)2-, ##-(CH2)6-diazacyclic heptanediol-(CH2)3-, ##-(CH2)6-diazacyclic heptanediol-(CH2)4-, ##-(CH2)6-diazacyclic heptanediol-(CH2)5-, ##-(CH2)6-diazacyclic heptanediol-(CH2)6-, ##-(CH2)6-diazacyclic heptanediol-(CH2)7-, ##-(CH2)6-diazacyclic heptanediol-(CH2)8-, ##-(CH2)7-diazacyclic heptanediol-(CH2)1-, ##-(CH2)7-diazacyclic heptanediol-(CH2)2-, ##-(CH2)7-diazacyclic Heptane-(CH2)3-, ##-(CH2)7-diazacyclic heptane-(CH2)4-, ##-(CH2)7-diazacyclic heptane-(CH2)8-, ##-(CH2)8-diazacyclic heptane-CH2-, ##-(CH2)8-diazacyclic heptane-(CH2)2-, ##-(CH2)8-diazacyclic heptane-(CH2)3-, ##-(CH2)8-diazacyclic heptane-(CH2)4-, ##-(CH2)8-diazacyclic heptane-(CH2)5-, ##-(CH2)8-diazacyclic heptane-(CH2)6-, ##-(CH2)8-diazacyclic heptane-(CH2) 7-, ##-(CH2)8-diazacyclic heptanediyl-(CH2)8-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-CH2-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)2-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)3-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)4-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)5-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)6-, ##-CH2-diazabicyclo[2.2.1]heptanediyl-(CH2)7-,##-CH2-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)2-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-CH2-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)5-, # #-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)3-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-CH2-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)4-, ## -(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)4-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)3-,##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)2-, ##-(C H2)6-diazabicyclo[2.2.1]heptane-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.1]heptane-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.1]heptane-(CH2)1-, ##-(CH2)7- Diazabicyclo[2.2.1]heptanyl-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)4-, ##-(CH2)7-diazabicyclo[2.2.1]heptanyl-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-CH2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-(CH2)2-, ##-(CH2)8-diazabicyclo[2.2.1]heptanyl-(CH2)3-, ##-(CH2)8-diazabicyclo[2. 2.1] Heptane-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)7-, ##-(CH2)8-diazabicyclo[2.2.1] Heptane-(CH2)8-, ##-CH2-diazabicyclo[3.1.1] Heptane-CH2-, ##-CH2-diazabicyclo[3.1.1] Heptane-(CH2)2-, ##-CH2-diazabicyclo[3.1.1] Heptane-(CH2)3-,##-CH2-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-CH2-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)1-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)2-diazabicyclo[3. 1.1] Heptane-(CH2)3-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)4-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)5-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)6-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)7-, ##-(CH2)2-diazabicyclo[3.1.1] Heptane-(CH2)8-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane-CH2-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane-CH2-, ##-(CH2)3-diazabicyclo[3.1.1] Heptane Heptane-(CH2)2-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-(CH2)3-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-C H2-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)7-, ##-(CH2)4-diazabicyclo[3.1.1]heptane-(CH2)8-,##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)1-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)7- 、##-(CH2)5-diazabicyclo[3.1.1]heptane-(CH2)8-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)1-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)2-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)3-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)4-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)5-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)6 -、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)7-、##-(CH2)6-diazabicyclo[3.1.1]heptane-(CH2)8-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)1-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)2-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)3-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2)4-、##-(CH2)7-diazabicyclo[3.1.1]heptane-(CH2) 8-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-CH2-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)2-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)3-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)5-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)6-, ##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)7-,##-(CH2)8-diazabicyclo[3.1.1]heptane-(CH2)8-, ##-CH2-diazabicyclo[3.2.1]octane-CH2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)3-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)5-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)6-, ##-CH2-diazabicyclo[3.2.1]octane Octane-(CH2)7-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)2-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)3-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)2-diazabicyclo[3.2.1]octane-( CH2)6-、##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)2-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)3-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2) )5-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)6-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)3-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)4-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)4-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)2-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)3- ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)5-diazabicyclo[3.2.1]octane-(CH2)8-, ##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)1-, ##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)2 -、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)5-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)6-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)7-、##-(CH2)6-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2) 1-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)4-、##-(CH2)7-diazabicyclo[3.2.1]octane-(CH2)8-、##-(CH2)8-diazabicyclo[3.2.1]octane-CH2-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)2-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)3-、##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)5-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)6-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)8-, ##-CH2-diazabicyclo[2.2.2]octane-CH2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[2.2.2]octane-(CH2)2-, ##-CH2-diazabicyclo[3.2.1]octane-(CH2)4-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)7-, ##-(CH2)8-diazabicyclo[3.2.1]octane-(CH2)8-, ##-CH2-diazabicyclo[3.2.2]octane-CH2-, ##-CH2-diazabicyclo[3.2.2]octane-(CH2) ... Bicyclic [2.2.2]octane-(CH2)3-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)4-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)5-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)6-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)7-, ##-CH2-diazabicyclic [2.2.2]octane-(CH2)8-, ##-(CH2)2-diazabicyclic [2.2.2]octane-(CH2)1-, ##-(CH2)2-diazabicyclic [2.2.2]octane-(C H2)2-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)3-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)4-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)5-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)6-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)7-、##-(CH2)2-diazabicyclo[2.2.2]octane-(CH2)8-、##-(CH2)3-diazabicyclo[2.2.2]octane-CH2 -、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)2-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)3-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)4-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)5-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)6-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)7-、##-(CH2)3-diazabicyclo[2.2.2]octane-(CH2)8-、##-(CH2)4-diazabicyclo[2.2.2]octane-CH2-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)6-, ##-(CH2)4-diazabicyclo[2.2.2]octane-(CH2)7-, ## -(CH2)4-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)6-, # #-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)7-, ##-(CH2)5-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)4-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)5-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)6-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)7-, ##-(CH2)6-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)1-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)4-,##-(CH2)7-diazabicyclo[2.2.2]octane-(CH2)8-, ##-(CH2)8-diazabicyclo[2.2.2]octane-CH2-, ##-(CH2)8-diazabicyclo[2.2.2]octane-(CH2)2-, ##-(CH2)8-diazabicyclo[2.2.2]octane-(CH2)3-, ##-(CH2)8-diazabicyclo[2.2. 2] Octane-(CH2)4-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)5-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)6-, ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)7-, or ##-(CH2)8-diazabicyclo[2.2.2] Octane-(CH2)8-;

[0551] Wherein, the propylidene, the piperidinyl, the piperazine, the diazacycloheptane, the diazabicyclo[2.2.1]heptane, the diazabicyclo[3.1.1]heptane, the diazabicyclo[3.2.1]octane, and the diazabicyclo[2.2.2]octane are independently and optionally further selected from deuterium, optionally deuterated C 1-4 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents;

[0552] Each R g10 Independently represent H or C 1-3 Alkyl groups; and

[0553] The symbol ## indicates the connection point with group X1.

[0554] In some embodiments of the compound of formula (I-2), L1 represents the following groups:

[0555]

[0556]

[0557] The symbol ## represents the connection point with group X1.

[0558] In some embodiments of the compound of formula (I-2), L1 represents the structure of the following formula: ##-C 1-30 alkylene-, wherein the C 1-30 The hydrogen atoms of one or more alkylene groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) CH2 may optionally be further substituted by substituents selected from: D, optionally deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 Alkyl, optional deuterated C 3-6 cycloalkyl, C 1-6 Alkoxy groups or any combination thereof, and the symbol ## indicates the connection point with group X1.

[0559] In some embodiments of the compound of formula (I-2), L1 represents the following groups:

[0560] ##-CH2-、##-(CH2)2-、##-(CH2)3-、##-(CH2)4-、##-(CH2)5-、##-(CH2)2-CF2-(CH2)2-、##-(CH2)6-、##-(CH2)7-、##-(CH2)8-、##-(CH2)9-、##-(CH2) 10 -、##-(CH2) 11 -、##-(CH2) 12 -、##-(CH2) 13 -、##-(CH2) 14 -、##-(CH2) 15 -、##-(CH2) 16 -、##-(CH2) 17 -、##-(CH2) 18 -、##-(CH2) 19 -、##-(CH2) 20 -、##-(CH2) 21 -、##-(CH2) 22 -、##-(CH2) 25 -、or ##-(CH2) 30 -;

[0561] The hydrogen atoms of one or more of the groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) of CH2 may optionally be further replaced by substituents selected from: D, optionally deuterated C 1-4 Alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6Alkyl, optional deuterated C 3-6 cycloalkyl, C 1-6 Alkoxy groups or any combination thereof, and the symbol ## indicates the connection point with group X1.

[0562] In some embodiments of the compound of formula (I-2), R b This indicates C that is optionally substituted with D or halogen. 1-60 Alkyl (e.g., C1-C) 30 Alkyl, C1-C 29 Alkyl, C1-C 28 Alkyl, C1-C 27 Alkyl, C1-C 26 Alkyl, C1-C 25 Alkyl, C1-C 24 Alkyl, C1-C 23 Alkyl, C1-C 22 Alkyl, C1-C 21 Alkyl, C1-C 20 Alkyl, C1-C 19 Alkyl, C1-C 18 Alkyl, C1-C 17 Alkyl, C1-C 16 Alkyl, C1-C 15 Alkyl, C1-C 14 Alkyl, C1-C 13 Alkyl, C1-C 12 Alkyl, C1-C 11 Alkyl, C1-C 10 Alkyl, C1-C9 alkyl, C1-C8 alkyl, C1-C7 alkyl, C1-C6 alkyl, C1-C5 alkyl, C1-C4 alkyl, C1-C3 alkyl, or C1-C2 alkyl).

[0563] In some embodiments of the compound of formula (I-2), R b Represents the following groups:

[0564] CH3, CF3, CD3, CH2CH3, -(CH2)2-CH3, -(CH2)3-CH3, -(CH2)4-CH3, -(CH2)5-CH3, -(CH2)6-CH3, -(CH2)7-CH3, -(CH2)8-CH3, -(CH2)9-CH3, -(CH2) 10 -CH3, -(CH2) 11 -CH3, -(CH2) 12 -CH3, -(CH2) 13 -CH3, -(CH2) 14 -CH3, -(CH2) 15-CH3, -(CH2) 16 -CH3, -(CH2) 17 -CH3, -(CH2) 18 -CH3, -(CH2) 19 -CH3, -(CH2) 20 -CH3, -(CH2) 21 -CH3, -(CH2) 22 -CH3, -(CH2) 23 -CH3, -(CH2) 24 -CH3, -(CH2) 25 -CH3, -(CH2) 26 -CH3, -(CH2) 27 -CH3, -(CH2) 28 -CH3, or -(CH2) 29 -CH3.

[0565] In some embodiments of the compound of formula (I-2), R b The following expression is represented:

[0566] R b1 -X4-L2-, where L2 represents:

[0567] Optionally, D or C can be selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1). 1-4 Alkyl, halogen, C 3-6 Substituents of the group consisting of cycloalkyl groups or any combination thereof, substituents of the straight or branched C-chain groups 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene

[0568] C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-C 26 Alkylene, C2-C 25 Alkylene, C2-

[0569] C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17Alkylene, C2-C 16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene, C2-C 10 Alkylene, C2-C9 alkylene

[0570] C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), or

[0571] One or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, ...) are inserted into its main carbon chain.

[0572] 1-4, 1-3, or 1-2, or 1 group R 12 And / or one or more (e.g., 1-20, or 1-15, 1-10, ...)

[0573] 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1 group R 13 and / or one or more

[0574] (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) group R 12 With R 13 Any combination of optionally substituted straight or branched C 2-60 Alkylene (e.g., C2-C) 40 Alkylene, C2-C 30 Alkylene, C2-C 29 Alkylene, C2-C 28 Alkylene, C2-C 27 Alkylene, C2-

[0575] C 26 Alkylene, C2-C 25 Alkylene, C2-C 24 Alkylene, C2-C 23 Alkylene, C2-C 22 Alkylene, C2-C 21 Alkylene, C2-C 20 Alkylene, C2-C 19 Alkylene, C2-C 18 Alkylene, C2-C 17 Alkylene, C2-C16 Alkylene, C2-C 15 Alkylene, C2-C 14 Alkylene, C2-C 13 Alkylene, C2-C 12 Alkylene, C2-C 11 Alkylene

[0576] C2-C 10 Alkylene, C2-C9 alkylene, C2-C8 alkylene, C2-C7 alkylene, C2-C6 alkylene, C2-C5 alkylene, C2-C4 alkylene, C2-C3 alkylene, or ethylene), wherein the group R 12 R 13 Or group R 12 With R 13 Any combination thereof breaks one or more pairs (e.g., 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2 pairs, or 1 pair) of carbon-carbon bonds between adjacent carbon atoms in the main carbon chain; each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O),

[0577] NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where R 14 Independently represent H or C 1-3 Alkyl groups, and when the straight-chain or branched C... 2-60 Two or more R groups are inserted into the main carbon chain of the alkylene group. 12 At that time, each group R 12 They are not directly connected to each other; each group R 13 Selected independently from C 3-15 Cycloalkylene, 4- to 15-membered heterocyclic cycloalkylene, C 6-10 arylene, 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the 4- to 15-membered heterocyclic alkylene group, C 6-10 The arylene and the 5- to 15-membered heteroarylene are each optionally further modified by one or more independent components.

[0578] (For example, 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) selected from D, optional deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3Alkyl groups, such as methyl,

[0579] CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl), optionally deuterated C 3-6 Cycloalkyl (e.g., optionally fully deuterated cyclopropyl, optionally fully deuterated cyclobutyl, optionally fully deuterated cyclopentyl, or optionally fully deuterated cyclohexyl), hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-,

[0580] CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-

[0581] C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl groups -C(O)NH-, such as CH3-C(O)NH-, CH3CH2-

[0582] Substitution with C(O)NH-, and CH3CH2CH2-C(O)NH-) or any combination thereof, and C of the straight or branched chain. 2-60 The alkylene group may optionally be selected from D or C by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3 or 1-2, or 1). 1-4 Alkyl (e.g., C10) 1-3 Alkyl groups, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, halogens, C 3-6 Substituents of cycloalkyl groups or any combination thereof;

[0583] X4 represents a bond, or X4 represents N(R) 15 ), C(O)O, OC(O), C(O)NH, NHC(O), C(O), O, C(S), S, S(O), S(O)2, S(O)2NH, NHS(O)2, S(O)2O, OS(O)2, optional substituted C 3-20 Cycloalkylene, optional substituted C 6-20 arylene, optionally substituted 4- to 20-membered heterocyclic arylene, optionally substituted 5- to 20-membered heterocyclic arylene, triazolyl-NH-, or -NH-triazolyl, wherein R 15 Indicates H or C 1-3 Alkyl groups, and the C 3-20 Cycloalkylene, the C 6-20 The aryl group, the 4- to 20-membered heterocyclic group, and the 5- to 20-membered heterocyclic group are each independently and optionally selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) from D, halogen, or optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 alkyl-

[0584] NHC(O)- (e.g., C) 1-3 Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and

[0585] CH3CH2CH2-NHC(O)-), C 1-4Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, for example CH3-

[0586] Substituents of C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-), or any combination thereof, are substituted; and

[0587] R b1 C represents an optional substitution 3-20 cycloalkyl, optional substituted C 6-20 Aryl, optionally substituted 4- to 20-membered heterocyclic groups, or optionally substituted 5- to 20-membered heteroaryl groups, wherein the C 3-20 cycloalkyl, the C 6-20 The aryl group, the 4- to 20-membered heterocyclic group, and the 5- to 20-membered heteroaryl group are each optionally and independently further selected by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) from D, optionally deuterated C. 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, with optional substituted C4 groups. 3-15 cycloalkyl, optionally substituted 4- to 15-membered heterocyclic groups, optionally substituted C 6-15 aryl, optionally substituted 5- to 15-membered heteroaryl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-, CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3Alkyl-NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-, C 1-4 Alkyl-C(O)NH- (e.g., C 1-3 Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-, or any combination thereof, substituted with substituents, and the C 3-15 cycloalkyl, the 4- to 15-membered heterocyclic group, the C 6-15 The aryl group and the 5- to 15-membered heteroaryl group are each optionally and independently represented by one or more (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1)

[0588] Selected from D, optional deuterated C 1-4 Alkyl groups (e.g., optionally deuterated C4) 1-3 Alkyl groups, such as methyl, CD3, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl; hydroxyl, amino, mercapto, halogen, cyano; C 1-4 Alkoxy groups (e.g., C) 1-3 Alkyl groups (such as methoxy, ethoxy, or propoxy groups), C 1-4 Alkyl-NH- (e.g., C) 1-3 Alkyl-NH-, such as CH3NH-, CH3CH2NH- or CH3CH2CH2NH-, and halogenated C- 1-4 Alkyl groups (e.g., halogenated C) 1-3 Alkyl groups, such as F3C-, FCH2-, F2CH-, ClCH2-, Cl2CH-, CF3CF2-, CF3CHF-, CHF2CF2-

[0589] CHF2CHF-, CF3CH2- or CH2ClCH2-), NH2-C 1-4 Alkylene (e.g., NH2-C) 1-3 Alkylenes, such as NH2CH2-, NH2CH2CH2- and NH2CH2CH2CH2-), C 1-4 Alkyl-NHC(O)- (e.g., C 1-3 alkyl-

[0590] NHC(O)-, such as CH3-NHC(O)-, CH3CH2-NHC(O)-, and CH3CH2CH2-NHC(O)-), C 1-4 Alkyl-C(O)NH- (e.g., C 1-3Alkyl-C(O)NH-, such as CH3-C(O)NH-, CH3CH2-C(O)NH-, and CH3CH2CH2-C(O)NH-, or any combination thereof, are substituted with substituents.

[0591] In some embodiments of the compound of formula (I-2), L2 represents the structure of the following formula: -C 2-30 alkylene-, wherein the C 2-30 The hydrogen atoms of one or more alkylene groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) CH2 may optionally be further substituted by substituents selected from: D, C 1-4 Alkyl (e.g., C10) 1-3 Alkyl groups, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, halogens, C 3-6 Cycloalkyl groups or any combination thereof.

[0592] In some embodiments of the compound of formula (I-2), L2 represents the following groups:

[0593] -CH2-, -(CH2)2-, -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)2-CF2-(CH2)2-, -(CH2)6-, -(CH2)7-, -

[0594] (CH2)8-, -(CH2)9-, -(CH2) 10 -、-(CH2) 11 -、-(CH2) 12 -、-(CH2) 13 -、-(CH2) 14 -、-(CH2) 15 -、-

[0595] (CH2) 16 -、-(CH2) 17 -、-(CH2) 18 -、-(CH2) 19 -、-(CH2) 20 -、-(CH2) 21 -、-(CH2) 22 -、-(CH2) 25 - or -(CH2) 30 -;

[0596] The hydrogen atoms of one or more of the groups (e.g., 1-20, or 1-15, 1-10, 1-9, 1-8, 1-7, 1-6, 1-5, 1-4, 1-3, or 1-2, or 1) of CH2 may optionally be further replaced by substituents selected from: D, C 1-4 Alkyl (e.g., C10) 1-3 Alkyl groups, such as methyl, ethyl, propyl, isopropyl, butyl, sec-butyl, or tert-butyl, halogens, C 3-6 Cycloalkyl groups or any combination thereof.

[0597] In some embodiments of the compound of formula (I-2), L2 represents the structure of the following formula:

[0598] -(C(R a9 (R) a10 )) m1 -(R 12 (C(R a11 (R) a12 )) m2 ) p1 -;

[0599] -(C(R a9 (R) a10 )) m1 -(R 12 (C(R a11 (R) a12 )) m2 ) p1 -(R 12 (C(R a13 (R) a14 )) m3 ) p2 -;

[0600] -(C(R a9 (R) a10 )) m1 -(R 12 (C(R a11 (R) a12 )) m2 ) p1 -(R 12 (C(R a13 (R) a14 )) m3 ) p2 -(R 12 (C(R a15 (R) a16 )) m4 ) p3 -;

[0601] -(C(R a9 (R) a10 ))m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -;

[0602] -(C(R a9 )(R a10 )) m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(R a13 )(R a14 )) m3 ) p2 -;

[0603] -(C(R a9 )(R a10 )) m1 -(R 13 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(R a13 )(R a14 )) m3 ) p2 -(R 13 (C(R a15 )(R a16 )) m4 ) p3 -;

[0604] -(C(R a9 )(R a10 )) m1 -(R 12 -R 13 -(C(R a11 )(R a12 )) m2 ) p1 -;

[0605] -(C(R a9 )(R a10 )) m1 -(R 12 (C(R a11 )(R a12 )) m2 ) p1 -(R 13 (C(R a13 )(Ra14 )) m3 ) p2 -;

[0606] -(C(R a9 (R) a10 )) m1 -(R 13 -R 12 -(C(R a11 (R) a12 )) m2 ) p1 -;or

[0607] -(C(R a9 (R) a10 )) m1 -(R 13 (C(R a11 (R) a12 )) m2 ) p1 -(R 12 (C(R a13 (R) a14 )) m3 ) p2 -;

[0608] Among them, each group R 12 Independently selected from O, S, N(R) 14 ), C(O), C(O)O, OC(O), C(O)NH, NHC(O), NHC(O)NH, C(S), S(O), S(O)2, S(O)2O, OS(O)2, S(O)2NH or NHS(O)2, where each R 14 Independently represent H or C 1-3 Alkyl groups; R groups 13 Independently selected from optional substitutions of C 3-15 Cycloalkylene, optionally substituted 4- to 15-membered heterocyclic alkylene, optionally substituted C 6-10 arylene, optionally substituted 5- to 15-membered heteroarylene, C 2-6 imidene group, C 2-6 alkyne or any combination thereof, wherein the C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-4 Alkyl, optional deuterated C 3-6 Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents;

[0609] R a9 R a10 R a11 R a12 R a13 R a14 R a15 and R a16 Each of the following can be represented independently: H, deuterium, halogen, and C. 1-4 Alkyl, C 3-6 cycloalkyl groups or any combination thereof; and

[0610] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0611] In some embodiments of the compound of formula (I-2), L2 represents the structure of the following formula:

[0612] -(C(R a9 (R) a10 )) m1 -(O(C(R a11 (R) a12 )) m2 ) p1 -;

[0613] -(C(R a9 (R) a10 )) m1 -(O(C(R a11 (R) a12 )) m2 ) p1 -(O(C(R a13 (R) a14 )) m3 ) p2 -;

[0614] -(C(R a9 (R) a10 )) m1 -(O(C(R a11 (R) a12 )) m2 ) p1 -(O(C(R a13 (R) a14 )) m3 ) p2 -(O(C(R a15)(R a16 )) m4 ) p3 -;

[0615] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -;

[0616] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -(N(R g11 )(C(R a13 )(R a14 )) m3 ) p2 -;

[0617] -(C(R a9 )(R a10 )) m1 -(N(R g11 )(C(R a11 )(R a12 )) m2 ) p1 -(N(R g11 )(C(R a13 )(R a14 )) m3 ) p2 -

[0618] (N(R g11 )(C(R a15 )(R a16 )) m4 ) p3 -;

[0619] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -;

[0620] -(C(R a9 )(R a10 ))m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(C(O)NH-(C(R a13 )(R a14 )) m3 ) p2 -;

[0621] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(C(O)NH-(C(R a13 )(R a14 )) m3 ) p2 -(C(O)NH-(C(R a15 )(R a16 )) m4 ) p3 -;

[0622] -(C(R a9 )(R a10 )) m1 -(C(O)NH-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -;

[0623] -(C(R a9 )(R a10 )) m1 -C(O)NH-(C(R a11 )(R a12 )) m2 -(O(C(R a13 )(R a14 )) m3 ) p1 -;

[0624] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1-;

[0625] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -;

[0626] -(C(R a9 )(R a10 )) m1 -(NHC(O)-(C(R a11 )(R a12 )) m2 ) p1 -(O-(C(R a13 )(R a14 )) m3 ) p2 -(O-(C(R a15 )(R a16 )) m4 ) p3 -;

[0627] -(C(R a9 )(R a10 )) m1 -NHC(O)-(C(R a11 )(R a12 )) m2 -(O(C(R a13 )(R a14 )) m3 ) p1 -;

[0628] -(C(R a9 )(R a10 )) m1 -NHC(O)NH-(C(R a11 )(R a12 )) m2 -;

[0629] -(C(R a9 )(R a10 )) m1 -C(O)-(C(R a11 )(R a12 )) m2 -;

[0630] -(C(Ra9 (R) a10 )) m1 -C(S)-(C(R a11 (R) a12 )) m2 -;

[0631] -(C(R a9 (R) a10 )) m1 -S-(C(R a11 (R) a12 )) m2 -;

[0632] -(C(R a9 (R) a10 )) m1 -(C 6-10 Aspartic-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0633] -(C(R a9 (R) a10 )) m1 -(C 6-10 Aspartic-(C(R) a11 (R) a12 )) m2 ) p1 -C 6-10 Aspartic-(C(R) a13 (R) a14 )) m3 -;

[0634] -(C(R a9 (R) a10 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0635] -(C(R a9 (R) a10 )) m1 -(4-to-15-membered heterocyclic group-(C(R) a11 (R) a12 )) m2 ) p1 -(4-to-15-membered heterocyclic group-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0636] -(C(R a9 (R) a10 )) m1 -(5-to-15-methylheteroaryl-(C(R) a11 (R) a12 )) m2 ) p1 -;

[0637] -(C(R a9 (R) a10 )) m1 -(5-to-15-methylheteroaryl-(C(R) a11 (R) a12 )) m2 ) p1 -(5-to-15-methylheteroaryl-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0638] -(C(R a9 (R) a10 )) m1 -(C 3-15 Cycloalkylene-(C(R) a11 (R) a12 )) m2 ) p1 -;or

[0639] -(C(R a9 (R) a10 )) m1 -(C 3-15 Cycloalkylene-(C(R) a11 (R) a12 )) m2 ) p1 -(C 3-15 Cycloalkylene-(C(R) a13 (R) a14 )) m3 ) p2 -;

[0640] Among them, each R g11 Independently represent H or C 1-3 alkyl;

[0641] The C 3-15 Cycloalkylene, the C 6-10 The arylene, the 4- to 15-membered heterocyclic arylene, and the 5- to 15-membered heterocyclic arylene are optionally further selected from deuterium, optionally deuterated C. 1-4 Alkyl, optional deuterated C 3-6Cycloalkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH-, Halogenated C 1-4 Alkyl, NH2-C 1-4 Alkylene, C 1-4 Alkyl-NHC(O)-, C 1-4 Alkyl-C(O)NH- or any combination thereof are substituents;

[0642] R a9 R a10 R a11 R a12 R a13 R a14 R a15 and R a16 Each of the following can be represented independently: H, deuterium, halogen, and C. 1-4 Alkyl, C 3-6 cycloalkyl groups or any combination thereof; and

[0643] m1, m2, m3, m4, p1, p2, p3 are each independently selected from the integers 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, or 15.

[0644] In some embodiments of the compound of formula (I-2), L2 represents the structure of the following formula:

[0645] -CH2-O-CH2-, -CH2-O-(CH2)2-, -(CH2)1-O-(CH2)3-, -(CH2)1-O-(CH2)4-, -(CH2)1-O-(CH2)5-, -(C H2)1-O-(CH2)6-, -(CH2)1-O-(CH2)7-, -(CH2)1-O-(CH2)8-, -(CH2)1-O-(CH2)9-, -(CH2)1-O-(CH2) 10 -, -(CH2)2-O-(CH2)1-, -(CH2)2-O-(CH2)2-, -(CH2)2-O-(CH2)3-, -(CH2)2-O-(CH2)4-, -(CH2)2-O-(CH2) 5-, -(CH2)2-O-(CH2)6-, -(CH2)2-O-(CH2)7-, -(CH2)2-O-(CH2)8-, -(CH2)2-O-(CH2)9-, -(CH2)2-O-(CH2) 10 -、-(CH2)2-O-(CH2) 11 -、-(CH2)2-O-(CH2) 12-、-(CH2)3-O-(CH2)1-、-(CH2)3-O-(CH2)2-、-(CH2)3-O-(CH2)3-、-(CH2)3-O-(CH2)4-、-(CH2)3-O-(CH2)5-、-(CH2)3-O-(CH2)6-、-(CH2)3-O-(CH2)7-、-(CH2)4-O-(CH2)1-、-(CH2)4-O-(CH2)2-、-(CH 2)4-O-(CH2)3-,-(CH2)4-O-(CH2)4-,-(CH2)4-O-(CH2)5-,-(CH2)4-O-(CH2)6-,-(CH2)5-O-(CH2)1-,-(CH2)5-O-(CH2)2-,-(CH2)5-O-(CH2)3-,-(CH2)5-O-(CH2)4-,-(CH2)5-O-(CH2)5-,-(CH2)6-O-( CH2)1-、-(CH2)6-O-(CH2)2-、-(CH2)6-O-(CH2)3-、-(CH2)6-O-(CH2)4-、-(CH2)7-O-(CH2)1-、-(CH2)7-O-(CH2)2-、-(CH2)7-O-(CH2)3-、-(CH2)8-O-(CH2)1-、-(CH2)8-O-(CH2)2-、-CH(CH3)-O-(CH2)1- -CH(CH3)-O-(CH2)2-, -CH(CH3)-O-(CH2)3-, -CH(CH3)-O-(CH2)4-, -CH(CH3)-O-(CH2)5-, -CH(CH3)-O-(CH2)6-, -CH(CH3)-O-(CH2)7-, -CH(CH3)-O-(CH2)8-, -CH(CH3)-O-(CH2)9-, -CH(CH3)-O-(CH2) 10 -CH2-(O(CH2)2)2- -CH2-(O(CH2)2)3- -CH2-(O(CH2)2)4- -CH2-(O(CH2)2)5- -CH2-(O(CH2)2)6- -CH2-(O(CH2)2)7- -CH2-(O(CH2)2)8- -CH2-(O(CH2)2)9- -CH2-(O(CH2)2) 10-、-CH2-(O(CH2)2)1-OCH2-、-CH2-(O(CH2)2)2-OCH2-、-CH2-(O(CH2)2)3-OCH2-、-CH2-(O(CH2)2)4-OCH2-、-CH2-(O(CH2)2)5-OCH2-、-CH2-(O(CH2)2)6-OCH2-、-CH2-(O(CH2)2)7-OCH2-、-CH2-(O(CH2)2)8-OCH2-、-CH2-(O(CH2)2)9-OCH2-、-CH2-(O(CH2)2) 10 -OCH2-、-(CH2)2-(O(CH2)2)2-、-(CH2)2-(O(CH2)2)3-、-(CH2)2-(O(CH2)2)4-、-(CH2)2-(O(CH2)2)5-、-(CH2)2-(O(CH2)2)6-、-(CH2)2-(O(CH2)2)7-、-(CH2)2-(O(CH2)2)8-、-(CH2)2-(O(CH2)2)9-、-(CH2)2-(O(CH2)2) 10 -、-(CH2)3-(O(CH2)2)2-、-(CH2)3-(O(CH2)2)3-、-(CH2)3-(O(CH2)2)4-、-(CH2)3-(O(CH2)2)5-、-(CH2)3-(O(CH2)2)6-、-(CH2)3-(O(CH2)2)7-、-(CH2)3-(O(CH2)2)8-、-(CH2)3-(O(CH2)2)9-、-(CH2)3-(O(CH2)2) 10 -、-(CH2)4-(O(CH2)2)2-、-(CH2)4-(O(CH2)2)3-、-(CH2)4-(O(CH2)2)4-、-(CH2)4-(O(CH2)2)5-、-(CH2)4-(O(CH2)2)6-、-(CH2)4-(O(CH2)2)7-、-(CH2)4-(O(CH2)2)8-、-(CH2)4-(O(CH2)2)9-、-(CH2)4-(O(CH2)2) 10 -、-CH2-(O(CH2)3)2-、-CH2-(O(CH2)3)3-、-CH2-(O(CH2)3)4-、-CH2-(O(CH2)3)5-、-CH2-(O(CH2)3)6-、-CH2-(O(CH2)3)7-、-CH2-(O(CH2)3)8-、-CH2-(O(CH2)3)9-、-CH2-(O(CH2)3) 10-、-(CH2)2-(O(CH2)3)2-、-(CH2)2-(O(CH2)3)3-、-(CH2)2-(O(CH2)3)4-、-(CH2)2-(O(CH2)3)5-、-(CH2)2-(O(CH2)3)6-、-(CH2)2-(O(CH2)3)7-、-(CH2)2-(O(CH2)3)8-、-(CH2)2-(O(CH2)3)9-、-(CH2)2-(O(CH2)3) 10 -、-(CH2)3-(O(CH2)3)2-、-(CH2)3-(O(CH2)3)3-、-(CH2)3-(O(CH2)3)4-、-(CH2)3-(O(CH2)3)5-、-(CH2)3-(O(CH2)3)6-、-(CH2)3-(O(CH2)3)7-、-(CH2)3-(O(CH2)3)8-、-(CH2)3-(O(CH2)3)9-、-(CH2)3-(O(CH2)3) 10-、-CH2-O-(CH2)2-O-(CH2)3-、-CH2-(O(CH2)2)2-(O(CH2)3)2-、-CH2-(O(CH2)2)3-(O(CH2)3)3-、-CH2-(O(CH2)2)4-(O(CH2)3)4-、-CH2-(O(CH2)2)5-(O(CH2)3)5-、-CH2-(O(CH2)2)6-(O(CH2)3)6-、-(CH2)2-O-(CH2)2-O-(CH2)3-、-(CH2)2-(O(CH2)2)2-(O(CH2)3)2-、-(CH2)2-(O(CH2)2)3-(O(CH2 )3)3-、-(CH2)2-(O(CH2)2)4-(O(CH2)3)4-、-(CH2)2-(O(CH2)2)5-(O(CH2)3)5-、-(CH2)2-(O(CH2)2)6-(O(CH2)3)6-、-(CH2)3-O-(CH2)2-O-(CH2)3-、-(CH2)3-(O(CH2)2)2-(O(CH2)3)2-、-(CH2)3-(O(CH2)2)3-(O(CH2)3)3-、-(CH2)3-(O(CH2)2)4-(O(CH2)3)4-、-(CH2)3-(O(CH2)2)5-(O(CH2)3)5- 、-(CH2)3-(O(CH2)2)6-(O(CH2)3)6-、-CH2-O-(CH2)3-O-(CH2)2-、-CH2-(O(CH2)3)2-(O(CH2)2)2-、-CH2-(O(CH2)3)3-(O(CH2)2)3-、-CH2-(O(CH2)3)4-(O(CH2)2)4-、-CH2-(O(CH2)3)5-(O(CH2)2)5-、-CH2-(O(CH2)3)6-(O(CH2)2)6-、-(CH2)2-O-(CH2)3-O-(CH2)2-、-(CH2)2-(O(CH2)3)2-(O(CH2) 2)2-、-(CH2)2-(O(CH2)3)3-(O(CH2)2)3-、-(CH2)2-(O(CH2)3)4-(O(CH2)2)4-、-(CH2)2-(O(CH2)3)5-(O(CH2)2)5-、-(CH2)2-(O(CH2)3)6-(O(CH2)2)6-、-(CH2)3-O-(CH2)3-O-(CH2)2-、-(CH2)3-(O(CH2)3)2-(O(CH2)2)2-、-(CH2)3-(O(CH2)3)3-(O(CH2)2)3-、-(CH2)3-(O(CH2)3)4-(O(CH2)2)4-、-(CH2)3-(O(CH2)3)5-(O(CH2)2)5-、-(CH2)3-(O(CH2)3)6-(O(CH2)2)6-、-CH2-O-(CH2)2-O-CH2-、-(CH2)2-O-(CH2)2-O-CH2-、-(CH2)2-(O(CH2)2)2-O-(CH2)3-、-(CH2)2-(O(CH2)2)3-O-(CH2)3-、-(CH2)2-(O(CH2)2)4-O-(CH2)3-、-(CH2)5-(O(CH2)2)2-O-(CH2)5-、-( CH2)5-(O(CH2)2)2-O-(CH2)6-、-CH2-C(O)-CH2-、-CH2-C(O)-(CH2)2-、-(CH2)1-C(O)-(CH2)3-、-(CH2)1-C(O)-(CH2)4-、-(CH2)1-C(O)-(CH2)5-、-(CH2)1-C(O)-(CH2)6-、-(CH2)1-C(O)-(CH2)7-、-(CH2)1-C(O)-(CH2)8-、-(CH2)1-C(O)-(CH2)9-、-(CH2)1-C(O)-(CH2)、 10 -、-(CH2)2-C(O)-(CH2)1-、-(CH2)2-C(O)-(CH2)2-、-(CH2)2-C(O)-(CH2)3-、-(CH2)2-C(O)-(CH2)4-、-(CH2)2-C(O)-(CH2)5-、-(CH2)2-C(O)-(CH2)6-、-(CH2)2-C(O)-(CH2)7-、-(CH2)2-C(O)-(CH2)8-、-(CH2)2-C(O)-(CH2)9-、-(CH2)2-C(O)-(CH2) 10 -、-(CH2)2-C(O)-(CH2) 11 -、-(CH2)2-C(O)-(CH2) 12-、-(CH2)3-C(O)-(CH2)1-、-(CH2)3-C(O)-(CH2)2-、-(CH2)3-C(O)-(CH2)3-、-(CH2)3-C(O)-(CH2)4-、-(CH2)3-C(O)-(CH2)5-、-(CH2)3-C(O)-(CH2)6-、-(CH2)3-C(O)-(CH2)7-、-(CH2)4-C(O)-(CH2)1-、-(CH2)4-C(O)-(CH2)2-、-(CH2)4-C(O)-(CH2)3-、-(CH2)4-C(O)-(CH2)4-、-(CH2)4-C(O)-(CH2)5-、-(CH2)4-C(O)-(CH2)6-、-(CH2)5-C(O)-(CH2)1-、-(CH2)5-C(O)-(CH2)2-、-(CH2)5-C(O)-(CH2)3-、-(CH2)5-C(O)-(CH2)4-、-(CH2)5-C(O)-(CH2)5-、-(CH2)6-C(O)-(CH2)1-、-(CH2)6-C(O)-(CH2)2-、-(CH2)6-C(O)-(CH2)3-、-(CH2)6-C(O)-(CH2)4-、-(CH2)7-C(O)-(CH2)1-、-(CH2)7-C(O)-(CH2)2-、-(CH2)7-C(O)-(CH2)3-、-(CH2)8-C(O)-(CH2)1-、-(CH2)8-C(O)-(CH2)2-、-CH2-S-CH2-、-CH2-S-(CH2)2-、-(CH2)1-S-(CH2)3-、-(CH2)1-S-(CH2)4-、-(CH2)1-S-(CH2)5-、-(CH2)1-S-(CH2)6-、-(CH2)1-S-(CH2)7-、-(CH2)1-S-(CH2)8-、-(CH2)1-S-(CH2)9-、-(CH2)1-S-(CH2) 10 -、-(CH2)2-S-(CH2)1-、-(CH2)2-S-(CH2)2-、-(CH2)2-S-(CH2)3-、-(CH2)2-S-(CH2)4-、-(CH2)2-S-(CH2)5-、-(CH2)2-S-(CH2)6-、-(CH2)2-S-(CH2)7-、-(CH2)2-S-(CH2)8-、-(CH2)2-S-(CH2)9-、-(CH2)2-S-(CH2) 10 -、-(CH2)2-S-(CH2) 11 -、-(CH2)2-S-(CH2) 12-、-(CH2)3-S-(CH2)1-、-(CH2)3-S-(CH2)2-、-(CH2)3-S-(CH2)3-、-(CH2)3-S-(CH2)4-、-(CH2)3-S-(CH2)5-、-(CH2)3-S-(CH2)6-、-(CH2)3-S-(CH2)7-、-(CH2)4-S-(CH2)1-、-(CH2)4-S-(CH2)2-、-(CH2)4-S-(CH2)3-、-(CH2)4-S-(CH2)4-、-(CH2)4-S-(CH2)5-、-(CH2)4-S-(CH2)6-、-(CH2)5-S-(CH2)1-、-(CH2)5-S-(CH2)2-、-(CH2)5-S-(CH2)3-、-(CH2)5-S-(CH2)4-、-(CH2)5-S-(CH2)5-、-(CH2)6-S-(CH2)1-、-(CH2)6-S-(CH2)2-、-(CH2)6-S-(CH2)3-、-(CH2)6-S-(CH2)4-、-(CH2)7-S-(CH2)1-、-(CH2)7-S-(CH2)2-、-(CH2)7-S-(CH2)3-、-(CH2)8-S-(CH2)1-、-(CH2)8-S-(CH2)2-、-CH2-C(S)-CH2-、-CH2-C(S)-(CH2)2-、-(CH2)1-C(S)-(CH2)3-、-(CH2)1-C(S)-(CH2)4-、-(CH2)1-C(S)-(CH2)5-、-(CH2)1-C(S)-(CH2)6-、-(CH2)1-C(S)-(CH2)7-、-(CH2)1-C(S)-(CH2)8-、-(CH2)1-C(S)-(CH2)9-、-(CH2)1-C(S)-(CH2) 10 -、-(CH2)2-C(S)-(CH2)1-、-(CH2)2-C(S)-(CH2)2-、-(CH2)2-C(S)-(CH2)3-、-(CH2)2-C(S)-(CH2)4-、-(CH2)2-C(S)-(CH2)5-、-(CH2)2-C(S)-(CH2)6-、-(CH2)2-C(S)-(CH2)7-、-(CH2)2-C(S)-(CH2)8-、-(CH2)2-C(S)-(CH2)9-、-(CH2)2-C(S)-(CH2) 10 -、-(CH2)2-C(S)-(CH2) 11 -、-(CH2)2-C(S)-(CH2) 12-、-(CH2)3-C(S)-(CH2)1-、-(CH2)3-C(S)-(CH2)2-、-(CH2)3-C(S)-(CH2)3-、-(CH2)3-C(S)-(CH2)4-、-(CH2)3-C(S)-(CH2)5-、-(CH2)3-C(S)-(CH2)6-、-(CH2)3-C(S)-(CH2)7-、-(CH2)4-C(S)-(CH2)1-、-(CH2)4-C(S)-(CH2)2-、-(CH2)4-C(S)-(CH2)3-、-(CH2)4-C(S)-(CH2)4-、-(CH2)4-C(S)-(CH2)5-、-(CH2)4-C(S)-(CH2)6-、-(CH2)5-C(S)-(CH2)1-、-(CH2)5-C(S)-(CH2)2-、-(CH2)5-C(S)-(CH2)3-、-(CH2)5-C(S)-(CH2)4-、-(CH2)5-C(S)-(CH2)5-、-(CH2)6-C(S)-(CH2)1-、-(CH2)6-C(S)-(CH2)2-、-(CH2)6-C(S)-(CH2)3-、-(CH2)6-C(S)-(CH2)4-、-(CH2)7-C(S)-(CH2)1-、-(CH2)7-C(S)-(CH2)2-、-(CH2)7-C(S)-(CH2)3-、-(CH2)8-C(S)-(CH2)1-、-(CH2)8-C(S)-(CH2)2-、-CH2-C(O)O-CH2-、-CH2-C(O)O-(CH2)2-、-(CH2)1-C(O)O-(CH2)3-、-(CH2)1-C(O)O-(CH2)4-、-(CH2)1-C(O)O-(CH2)5-、-(CH2)1-C(O)O-(CH2)6-、-(CH2)1-C(O)O-(CH2)7-、-(CH2)1-C(O)O-(CH2)8-、-(CH2)1-C(O)O-(CH2)9-、-(CH2)1-C(O)O-(CH2) 10-、-(CH2)2-C(O)O-(CH2)1-、-(CH2)2-C(O)O-(CH2)2-、-(CH2)2-C(O)O-(CH2)3-、-(CH2)2-C(O)O-(CH2)4-、-(CH2)2-C(O)O-(CH2)5-、-(CH2)2-C(O)O-(CH2)6-、-(CH2)2-C(O)O-(CH2)7-、-(CH2)2-C(O)O-(CH2)8-、-(CH2)2-C(O)O-(CH2)9-、-(CH2)2-C(O)O-(CH2) 10 -、-(CH2)2-C(O)O-(CH2) 11 -、-(CH2)2-C(O)O-(CH2) 12-、-(CH2)3-C(O)O-(CH2)1-、-(CH2)3-C(O)O-(CH2)2-、-(CH2)3-C(O)O-(CH2)3-、-(CH2)3-C(O)O-(CH2)4-、-(CH2)3-C(O)O-(CH2)5-、-(CH2)3-C(O)O-(CH2)6-、-(CH2)3-C(O)O-(CH2)7-、-(CH2)4-C(O)O-(CH2)1-、-(CH2)4-C(O)O-(CH2)2-、- (CH2)4-C(O)O-(CH2)3-、-(CH2)4-C(O)O-(CH2)4-、-(CH2)4-C(O)O-(CH2)5-、-(CH2)4-C(O)O-(CH2)6-、-(CH2)5-C(O)O-(CH2)1-、-(CH2)5-C(O)O-(CH2)2-、-(CH2)5-C(O)O-(CH2)3-、-(CH2)5-C(O)O-(CH2)4-、-(CH2)5-C(O)O-(CH2)5-、-(CH 2)6-C(O)O-(CH2)1-,-(CH2)6-C(O)O-(CH2)2-,-(CH2)6-C(O)O-(CH2)3-,-(CH2)6-C(O)O-(CH2)4-,-(CH2)7-C(O)O-(CH2)1-,-(CH2)7-C(O)O-(CH2)2-,-(CH2)7-C(O)O-(CH2)3-,-(CH2)8-C(O)O-(CH2)1-,-(CH2)8-C(O)O-(CH2)2-,-CH2-OC (O)-CH2-、-CH2-OC(O)-(CH2)2-、-(CH2)1-OC(O)-(CH2)3-、-(CH2)1-OC(O)-(C...

Claims

1. A compound of formula (I) or a salt, enantiomer thereof, Formula (I) wherein R c1 represents H or C 1-3 alkyl, R c2 , R c3 , R c4 , R c5 and R c6 are identical or different and each independently represent H, D or C 1-3 alkyl; (R 1a ) n The quinazoline ring of formula (I) is optionally substituted with n R 1a wherein R 1a represents halo, and n represents an integer 0, 1, 2, or 3; and R a represents the following formula: R a1 X2-L1-X1-, wherein, X1represents N(R1), O, or S, wherein R1represents H or C 1-3 alkyl, or X1represents a bond; L1represents straight chain or branched C1-6alkyl optionally substituted by one or more substituents selected from the group consisting of D, C 1-4 alkyl, hydroxy, amino, mercapto, nitro, halogen, cyano, haloC 1-6 alkyl and C 1-6 alkoxy; and L2represents a bond or a straight chain or branched C1-6alkylene group; wherein each C1-6alkyl, C1-6alkoxy, C1-6alkylene and C1-6alkynylene group is optionally substituted by one or more substituents selected from the group consisting of D, C 1-10 alkylene; X2represents N(R2), wherein R2represents H or C 1-3 alkyl; and R a1 represents optionally substituted adamantyl, optionally substituted noradamantyl, optionally substituted cubanyl, optionally substituted bicyclo[2.2.2]octan-1-yl, optionally substituted bicyclo[2.2.2]octan-2-yl, optionally substituted borneolyl, or optionally substituted bicyclo[2.2.1]heptan-1-yl, wherein each of said adamantyl, noradamantyl, cubanyl, bicyclo[2.2.2]octan-1-yl, bicyclo[2.2.2]octan-2-yl, borneolyl, or bicyclo[2.2.1]heptan-1-yl is independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C 1-4 alkyl, hydroxyl, amino, thiol, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and halogenated C 1-4 alkyl; or X1represents N(R6), O or S, wherein R6represents H or C 1-3 alkyl; L1represents an optionally substituted straight-chain or branched C 2-10 alkylene, wherein said groups R7or R8interrupt one to three carbon-carbon bonds between one to three pairs of adjacent carbon atoms of the main carbon chain of said straight-chain or branched C 2-10 when more than two groups R7are inserted in the main carbon chain of said straight-chain or branched C 1-4 alkylene, wherein said groups R7or R8interrupt one to three carbon-carbon bonds between one to three pairs of adjacent carbon atoms of the main carbon chain of said straight-chain or branched C 1-4 alkyl, hydroxy, amino, mercapto, halogen, C 1-4 alkoxy, C 1-4 alkyl-NH-, haloC 2-10 alkyl, and cyano, and said straight-chain or branched C 1-4 alkylene is optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C 1-6 alkyl, and C 1-6 alkoxy; X2represents N(R 10 ), wherein R 10 represents H or C 1-3 alkyl, or X2represents a bond; and R a1 represents a quinuclidinyl group, an adamantyl group, a noradamantyl group, a bornyl group, a bicyclo[2.2.1]heptyl group or a 2-oxobicyclo[2.2.1]heptyl group, 2.2.1] heptane, wherein each group is independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxyl, amino, thiol, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and haloC 1-4 substituted with one or more substituents selected from the group consisting of D, optionally deuterated C and R b represents optionally Ci-C4alkyl or halo-substituted C 1-2 alkyl.

2. The compound of formula (I) or a salt, enantiomer thereof of claim 1, which is also a compound of formula (II) or a compound of formula (III): wherein the radicals R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R a , (R 1a ) n and R b are as defined in claim 1.

3. The compound of formula (I) or a salt, enantiomer thereof of claim 1, which is also a compound of formula (la), formula (lb), formula (lc), formula (Id), formula (lla), formula (lib), formula (lie), formula (lid), formula (Ilia), formula (Illb), formula (IIIc), or formula (IIId): wherein the radicals R c1 , R c2 , R c3 , R c4 , R c5 , R c6 , R a , (R 1a ) n and R b are as defined in claim 1.

4. The compound of formula (I) or a salt, enantiomer thereof of any one of claims 1-3, wherein R a represents the following formula: R a1 X2-L1-X1-, wherein, X1represents a bond or X1represents N(R1), O, or S, wherein R1represents H or C 1-3 alkyl; L1 indicates that it can be optionally selected by one or more choices D, and C can be optionally deuterated. 1-4 Alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, halogenated C 1-6 Alkyl and C 1-6 The substituents of the alkoxy group substituted for straight or branched C atoms 1-8 Alkylene; X2represents N(R2), wherein R2represents H or C 1-3 alkyl; and R a1 represents an optionally substituted adamantyl group, an optionally substituted noradamantyl group, an optionally substituted cubanyl group, an optionally substituted bicyclo[2.2.2]octan-1-yl group, an optionally substituted bicyclo[2.2.2]octan-2-yl group, an optionally substituted borneolyl group, or an optionally substituted bicyclo[2.2.1]heptan group, wherein each of the adamantyl group, noradamantyl group, cubanyl group, bicyclo[2.2.2]octan-1-yl group, bicyclo[2.2.2]octan-2-yl group, borneolyl group, or bicyclo[2.2.1]heptan group is independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C 1-4 alkyl, hydroxyl, amino, thiol, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and halogenated C 1-4 alkyl; and R b represents C 1-2 alkyl optionally substituted with D or halogen.

5. The compound of formula (I) or a salt, enantiomer thereof of any one of claims 1-3, wherein R a represents the following formula: R a1 X2-L1-X1-, wherein, X1represents N(R6), O, or S, wherein R6represents H or C 1-3 alkyl; L1represents an optionally substituted straight-chain or branched C 2-8 alkylene, wherein said groups R7or R8interrupt one or two carbon-carbon bonds between one or two pairs of adjacent carbon atoms of the main carbon chain of said straight-chain or branched C 2-8 when more than two groups R7are inserted in the main carbon chain of said straight-chain or branched C 1-4 alkylene, wherein said groups R7or R8interrupt one or two carbon-carbon bonds between one or two pairs of adjacent carbon atoms of the main carbon chain of said straight-chain or branched C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and halogenated C 2-8 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-6 alkyl, and C 1-6 alkoxy; X2represents a bond or X2represents N(R 10 ), wherein R 10 represents H or C 1-3 alkyl; and R a1 represents a quinuclidinyl, adamantyl, noradamantyl, borneolyl, bicyclo[2.2.1]heptyl or 2-oxobicyclo[2.2.1]heptyl group. 2.2.1] heptane, wherein each group is independently optionally substituted with one or more substituents selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxyl, amino, thiol, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and haloC 1-4 substituted with one or more substituents selected from the group consisting of D, optionally deuterated C and R b represents optionally Ci-C4alkyl or halo-substituted C 1-2 alkyl.

6. The compound of formula (I) according to claim 4, wherein R represents: ###0002### or a salt, enantiomer thereof. a1 represents: ###0003### adamant-1-yl, adamant-2-yl, adamant-3-yl, adamant-4-yl, adamant-5-yl, adamant-6-yl, adamant-7-yl, adamant-8-yl, adamant-9-yl, adamant-10-yl, noradamant-1-yl, noradamant-2-yl, noradamant-3-yl, noradamant-4-yl, noradamant-5-yl, noradamant-6-yl, noradamant-7-yl, noradamant-8-yl, noradamant-9-yl, cubanyl, bicyclo[2.2.2]oct-1-yl, bicyclo[2.2.2]oct-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-2-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-3-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-4-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-5-yl, 1,7,7-trimethylbicyclo[2.2.1]hept-6-yl, , bicyclo[2.2.1]hept-2-yl, bicyclo[2.2.1]hept-3-yl, bicyclo[2.2.1]hept-4-yl, bicyclo[2.2.1]hept-5-yl, bicyclo[2.2.1]hept-6-yl, 7,7-dimethyl-2-oxobicyclo[ 2.2.1]heptan-1-yl, 7,7-dimethyl-2-oxobicyclo[ 2.2.1]heptan-3-yl, 7,7-dimethyl-2-oxobicyclo[ 2.2.1]heptan-4-yl, 7,7-dimethyl-2-oxobicyclo[ 2.2.1]heptan-5-yl, or 7,7-dimethyl-2-oxobicyclo[ 2.2.1] heptyl-6-yl, each group independently optionally substituted with one or more substituents selected from the group consisting of D, halogen, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and halogenated C 1-4 alkyl groups.

7. The compound of formula (I) or a salt, enantiomer thereof of claim 4, wherein R a1 Indicates: 。 8. The compound of formula (I) or a salt, enantiomer thereof of claim 5, wherein L1 represents a structure of formula: ##-(C(R a1 (R) a2 )) m1 -(R7(C(R a3 (R) a4 )) m2 ) p1 -;or ##-(C(R a1 )(R a2 )) m1 -(R8(C(R a3 )(R a4 )) m2 ) p1 -; wherein Each group R7 is independently selected from O; each group R8 is independently selected from 4- to 9-membered heterocyclic groups containing 1 to 3 heteroatoms independently selected from sulfur, oxygen, and nitrogen, wherein the 4- to 9-membered heterocyclic groups are optionally further selected from D, or optionally deuterated C. 1-4 Alkyl, hydroxyl, amino, mercapto, halogen, cyano, C 1-4 Alkoxy, C 1-4 Alkyl-NH- and halogenated C 1-4 Alkyl substituents; R a1 , R a2 , R a3 , and R a4 each independently represent H, deuterium, C 1-4 alkyl, or halogen; the symbol ## indicates the point of attachment to X1; and m1, m2, p1 are each independently selected from an integer 1 or 2.

9. The compound of formula (I) or a salt, enantiomer thereof of claim 5, wherein L1 represents a structure of formula: ##-(C(R a1 )(R a2 )) m1 -(O(C(R a3 )(R a4 )) m2 ) p1 -; or ##-(C(R a1 )(R a2 )) m1 -(4- to 9-membered heterocyclylidene-(C(R a3 )(R a4 )) m2 ) p1 -; wherein The 4- to 9-membered heterocyclylene group contains 1 to 3 heteroatoms independently selected from sulfur, oxygen, and nitrogen and is optionally further substituted with D, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and haloC 1-4 substituted with a substituent selected from the group consisting of alkyl, hydroxy, amino, mercapto, halogen, cyano, C R a1 , R a2 , R a3 , and R a4 each independently represent H, deuterium, C 1-4 alkyl, or halogen; the symbol ## indicates the point of attachment to group X1; and m1, m2, p1 are each independently selected from an integer 1 or 2.

10. The compound of formula (I) or a salt, enantiomer thereof of claim 1, wherein L1 represents a group of formula: ##-CH2-O-CH2-, ##-CH2-O-(CH2)2-, ##-(CH2)1-O-(CH2)3-, ##-(CH2)1-O-(CH2)4-, ##-(CH2)2-O-(CH2)1-, ##-(CH2)2-O-(CH2)2-, ##-(CH2)2-O-(CH2)3-, ##-(CH2)2-O-(CH2)4-, ##-(CH2)3-O-(CH2)1-, ##-(CH2)3-O-(CH2)2-, ##-(CH2)3-O-(CH2)3-, ##-(CH2)3-O-(CH2)4-, ##-(CH2)4-O-(CH2)1-, ##-(CH2)4-O-(CH2)2-, ##-(CH2)4-O-(CH2)3-, ##-(CH2)4-O-(CH2)4-, ##-CH(CH3)-O-(CH2)1-, ##-CH(CH3)-O-(CH2)2-, ##-CH(CH3)-O-(CH2)3-, ##-CH(CH3)-O-(CH2)4-, ##-CH2-(O(CH2)2)2-, ##-CH2-(O(CH2)2)1-OCH2-, ##-CH2-(O(CH2)2)2-OCH2-, ##-(CH2)2-(O(CH2)2)2-, ##-(CH2)3-(O(CH2)2)2-, ##-(CH2)4-(O(CH2)2)2-, ##-CH2-(O(CH2)3)2-, ##-(CH2)2-(O(CH2)3)2-, ##-(CH2)3-(O(CH2)3)2-, ##-CH2-O-(CH2)2-O-(CH2)3-, ##-(CH2)2-O-(CH2)2-O-(CH2)3-, ##-(CH2)3-O-(CH2)2-O-(CH2)3-, ##-CH2-O-(CH2)3-O-(CH2)2-, ##-(CH2)2-O-(CH2)3-O-(CH2)2-, ##-(CH2)3-O-(CH2)3-O-(CH2)2-, ##-CH2-O-(CH2)2-O-CH2-, ##-(CH2)2-O-(CH2)2-O-CH2-, ##-CH2-piperidinylene-CH2-, ##-CH2-piperidinylene-(CH2)2-, ##-CH2-piperidinylene-(CH2)3-, ##-CH2-piperidinylene-(CH2)4-, ##-CH2-piperidinylene-(CH2)5-, ##-CH2-piperidinylene-(CH2)6-, ##-CH2-piperidinylene-(CH2)7-, ##-CH2-piperidinylene-(CH2)8-, ##-(CH2)2-piperidinylene-(CH2)1-,##-(CH2)2-piperidinyl-(CH2)2-, ##-(CH2)2-piperidinyl-(CH2)3-, ##-(CH2)2-piperidinyl-(CH2)4-, ##-(CH2)2-piperidinyl-(CH2)5-, ##-(CH2)2-piperidinyl-(CH2)6-, ##-(CH2)2-piperidinyl-(CH2)7-, ##-(CH2)2-piperidinyl-(CH2)8-, ##-(CH2)3-piperidinyl-CH2-, ##-(CH2)3-piperidinyl-(CH2)2-, ##-(CH2)3-piperidinyl-(CH2)3-, ##-(CH2)3-piperidinyl-(CH2)4- ##-(CH2)3-piperidinyl-(CH2)5-, ##-(CH2)3-piperidinyl-(CH2)6-, ##-(CH2)3-piperidinyl-(CH2)7-, ##-(CH2)4-piperidinyl-CH2-, ##-(CH2)4-piperidinyl-(CH2)2-, ##-(CH2)4-piperidinyl-(CH2)3-, ##-(CH2)4-piperidinyl-(CH2)4-, ##-(CH2)4-piperidinyl-(CH2)5-, ##-(CH2)4-piperidinyl-(CH2)6-, ##-(CH2)5-piperidinyl-(CH2)1-, ##-(CH2)5-piperidinyl-(CH2)2- ##-(CH2)5-piperidinyl-(CH2)3-, ##-(CH2)5-piperidinyl-(CH2)4-, ##-(CH2)5-piperidinyl-(CH2)5-, ##-(CH2)6-piperidinyl-(CH2)1-, ##-(CH2)6-piperidinyl-(CH2)2-, ##-(CH2)6-piperidinyl-(CH2)3-, ##-(CH2)6-piperidinyl-(CH2)4-, ##-(CH2)7-piperidinyl-(CH2)1-, ##-(CH2)7-piperidinyl-(CH2)2-, ##-(CH2)7-piperidinyl-(CH2)3-, ##-(CH2)8-piperidinyl-CH2- ##-(CH2)8-piperazinyl-(CH2)2-, ##-CH2-piperazinyl-CH2-, ##-CH2-piperazinyl-(CH2)2-, ##-CH2-piperazinyl-(CH2)3-, ##-CH2-piperazinyl-(CH2)4-, ##-CH2-piperazinyl-(CH2)5-, ##-CH2-piperazinyl-(CH2)6-, ##-CH2-piperazinyl-(CH2)7-, ##-CH2-piperazinyl-(CH2)8-, ##-(CH2)2-piperazinyl-(CH2)1-, ##-(CH2)2-piperazinyl-(CH2)2-, ##-(CH2)2-piperazinyl-(CH2)3-,## -(CH2)2-piperazinylene-(CH2)4-, ## -(CH2)2-piperazinylene-(CH2)5-, ## -(CH2)2-piperazinylene-(CH2)6-, ## -(CH2)2-piperazinylene-(CH2)7-, ## -(CH2)2-piperazinylene-(CH2)8-, ## -(CH2)3-piperazinylene-CH2-, ## -(CH2)3-piperazinylene-(CH2)2-, ## -(CH2)3-piperazinylene-(CH2)3-, ## -(CH2)3-piperazinylene-(CH2)4-, ## -(CH2)3-piperazinylene-(CH2)5-, ## -(CH2)3-piperazinylene-(CH2)6-, ## -(CH2)3-piperazinylene-(CH2)7-, ## -(CH2)4-piperazinylene-CH2-, ## -(CH2)4-piperazinylene-(CH2)2-, ## -(CH2)4-piperazinylene-(CH2)3-, ## -(CH2)4-piperazinylene-(CH2)4-, ## -(CH2)4-piperazinylene-(CH2)5-, ## -(CH2)4-piperazinylene-(CH2)6-, ## -(CH2)5-piperazinylene-(CH2)1-, ## -(CH2)5-piperazinylene-(CH2)2-, ## -(CH2)5-piperazinylene-(CH2)3-, ## -(CH2)5-piperazinylene-(CH2)4-, ## -(CH2)5-piperazinylene-(CH2)5-, ## -(CH2)6-piperazinylene-(CH2)1-, ## -(CH2)6-piperazinylene-(CH2)2-, ## -(CH2)6-piperazinylene-(CH2)3-, ## -(CH2)6-piperazinylene-(CH2)4-, ## -(CH2)7-piperazinylene-(CH2)1-, ## -(CH2)7-piperazinylene-(CH2)2-, ## -(CH2)7-piperazinylene-(CH2)3-, ## -(CH2)8-piperazinylene-CH2-, or ## -(CH2)8-piperazinylene-(CH2)2-; wherein, said piperidinylene group and said piperazinylene group are each independently optionally further substituted by a substituent selected from the group consisting of deuterium, optionally deuterated C 1-4 alkyl, hydroxy, amino, mercapto, halogen, cyano, C 1-4 alkoxy, C 1-4 alkyl-NH-, and halogenated C 1-4 alkyl; and the symbol ## indicates the point of attachment to X1.

11. The compound of formula (I) or a salt, enantiomer thereof of claim 5, wherein L1 represents a group of formula: ； wherein the symbol ## indicates the point of attachment to group X1.

12. The compound of formula (I) or a salt, enantiomer thereof of claim 1, wherein L1 represents a group of formula: ##-CH2-, ##-(CH2)2-, ##-(CH2)3-, ##-(CH2)4-, ##-(CH2)5-, ##-(CH2)2-CF2-(CH2)2-, ##-(CH2)6-, ##-(CH2)7-, ##-(CH2)8-, ##-(CH2)9-, or ##-(CH2) 10 -; wherein the hydrogen of one or more CH2in said group is optionally further replaced by a substituent selected from the group consisting of D, optionally deuterated C 1-4 alkyl, hydroxyl, amino, mercapto, nitro, halogen, cyano, haloC 1-6 alkyl, and C 1-6 alkoxy, and the symbol ## indicates the point of attachment to X1.

13. The compound of formula (I) according to claim 4 or 5, wherein R represents the following group: ###00016### or a salt, enantiomer thereof. b represents the following group: CH3, CF3, CD3, or CH2CH3.

14. The compound of formula (I) or a salt, enantiomer thereof of claim 1, selected from: 3-(5-((4-(((3s,5s,7s)-adamantan-1-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1s,3s)-adamantan-1-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((6-(((3s,5s,7s)-adamantan-1-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantan-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(((1s,3s)-adamantan-1-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(((1r,3r,5r,7r)-adamantan-2-yl)amino)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(((1r,3r,5r,7r)-adamantan-2-yl)amino)propyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(((1r,3r,5r,7r)-adamantan-2-yl)amino)butyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((1r,3r,5r,7r)-adamantan-2-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((5-(((3as,6as)-hexahydro-2,5-methanocyclopentadien-3a(1H)-yl)amino)pentyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((6-(((2R,3as,5S,6as)-hexahydro-2,5-methanocyclopentadien-3a(1H)-yl)amino)hexyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((3as,6as)-hexahydro-2,5-methanocyclopentadien-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(((3as,6as)-hexahydro-2,5-methanocyclopentadien-3a(1H)-yl)amino)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-(((2R,3as,5S,6as)-hexahydro-2,5-methanocyclopentadien-3a(1H)-yl)amino)ethoxy)ethoxy)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantane-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-((4-fluorobicyclo[2.2.2]octane-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazoline-3(4H)-yl)piperidine-2,6-dione; 3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantane-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-((((3as,6as)-hexahydro-2,5-methylbridgedcyclopentadien-3a(1H)-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamantane-1-yl)amino)heptyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidin-2,6-dione; (S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptane-2-yl)amino)heptyl)amino)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantane-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((3as,6as)-hexahydro-2,5-methylbridgedcyclopentadien-3a(1H)-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(2-(2-((((3s,5s,7s)-adamantane-1-yl)amino)ethoxy)ethoxy)ethyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamantane-1-yl)amino)heptyl)amino)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-((4-Fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2- (trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; 3-(4-Oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan- 2-yl)amino)heptyl)amino)quinolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamant-1-yl)amino)heptyl)amino)-4- oxo-2-(trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((3as,6as)-Hexahydro-2,5-methanocyclopenta[d]pyrrol-3a(1H)-yl)amino) heptyl)amino)-4-oxo-2-(trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)amino)-4-oxo-2- (trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-((4-Fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)amino)-4-oxo-2- (trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(4-Oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan- 2-yl)amino)heptyl)amino)quinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(5-((5-(((1s,3s)-adamant-1-yl)amino)-3,3-difluoropentyl)amino)-2-methyl-4- oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamant-1-yl)amino)heptyl)thio)-4-oxo-2- (trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)thio)-4-oxo-2-(trifluoromethyl)quinolin- 3(4H)-yl)piperidine-2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2- yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamant-1-yl)amino)heptyl)thio)-2- methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)thio)-2-methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2- yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-((7-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2- yl)amino)heptyl)thio)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-((4-fluorobicyclo[2.2.2]octan-1-yl)amino)heptyl)thio)-4-oxo-2- (trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-((7-(((1s,3s)-adamant-1-yl)amino)heptyl)thio)-4-oxo-2- (trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-((7-(((1SR,3RS,5SR,7r)-3,5-dimethyladamant-1-yl)amino)heptyl)thio)-4-oxo-2- (trifluoromethyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(5-(((3s,5s,7s)-adamant-1-yl)amino)pentyl)-2-methyl-4-oxoquinazolin-3(4H)- yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3s)-adamant-1-yl)amino)octyl)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine- 2,6-dione; 3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2- yl)amino)octyl)quinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(8-(((1s,3s)-adamant-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinazolin-3(4H)- yl)piperidine-2,6-dione; (S)-3-(2-methyl-4-oxo-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2- yl)amino)octyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((3as,6as)-hexahydro-2,5-methanocyclopenta[d]pyrrol-3a(1H)- yl)amino)octyl)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; (S)-3-(5-(8-(((1SR,3RS,5SR,7r)-3,5-dimethyladamantan-1-yl)amino)octyl)-4-oxo-2- (trifluoromethyl)quinolin-3(4H)-yl)piperidine-2,6-dione; (3R)-3-(5-(8-(((1s,3s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinolin- 3(4H)-yl)piperidine-2,6-dione; (S)-3-(4-oxo-2-(trifluoromethyl)-5-(8-(((1R,2S,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan- 2-yl)amino)octyl)quinolin-3(4H)-yl)piperidine-2,6-dione 3-(6-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(6-(5-(((1s,3s)-adamantan-1-yl)amino)pentyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(6-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(7-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinolin- 3(4H)-yl)piperidine-2,6-dione; 3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-2-methyl-4-oxoquinolin-3(4H)- yl)piperidine-2,6-dione; 3-(8-(8-(((3s,5s,7s)-adamantan-1-yl)amino)octyl)-4-oxo-2-(trifluoromethyl)quinolin- 3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-((((3s,5s,7s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(2-(((1s,3s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(3-(((3s,5s,7s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)ethyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-((((1s,3s)-adamantan-1-yl)amino)methyl)piperazin-1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(2-(((3s,5s,7s)-adamantan-1-yl)amino)ethyl)piperazin-1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(3-(4-(3-(((1s,3s)-adamantan-1-yl)amino)propyl)piperazin-1-yl)propyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)methyl)-2-methyl-4-oxoquinazolin- 3(4H)-yl)piperidine-2,6-dione; 3-(5-((4-(7-(((1s,3s)-adamantan-1-yl)amino)heptyl)piperazin-1-yl)methyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)sulfanyl)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(((1s,3s)-adamantan-1-yl)methyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(((3r,5r,7r)-adamantan-1-yl)methyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-(2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethoxy)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(6-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(7-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(8-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)propyl)thio)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(6-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(7-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(8-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)piperazin-1-yl)ethyl)amino)-2- methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(trifluoromethyl)piperazin-1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)propyl)thio)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((3-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)propyl)thio)-2-methyl-4- oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]octan-6-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(6-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,6-diazabicyclo[3.1.1]octan-3-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(3-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-8-yl)ethyl)amino)- 2-methyl-4-oxoquinazolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(8-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,8-diazabicyclo[3.2.1]octan-3- yl)ethyl)amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(5-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.2]octan-2- yl)ethyl)amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-((1S,4S)-5-(2-((3S,5S,7S)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)ethyl)amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-((1R,4R)-5-(2-((3R,5R,7R)-adamantan-1-yl)ethyl)-2,5-diazabicyclo[2.2.1]heptan- 2-yl)ethyl)amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3,5-dimethylpiperazin-1-yl)ethyl)amino)- 2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,6-dimethylpiperazin-1-yl)ethyl)amino)- 2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-3-(trifluoromethyl)piperazin-1-yl)ethyl) amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2-(fluoromethyl)piperazin-1-yl)ethyl) amino)-2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-2,2-dimethylpiperazin-1-yl)ethyl)amino)- 2-methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione; or 3-(5-((2-(4-(2-((3r,5r,7r)-adamantan-1-yl)ethyl)-1,4-diazepan-1-yl)ethyl)amino)-2- methyl-4-oxoquinolin-3(4H)-yl)piperidine-2,6-dione.

15. The compound of formula (I) or its salt, enantiomer of claim 1, which is a hydrochloride, sulfate, citrate, maleate, sulfonate, citrate, lactate, tartrate, fumarate, phosphate, dihydrogen phosphate, pyrophosphate, metaphosphate, oxalate, malonate, benzoate, mandelate, succinate, trifluoroacetate, glycolate or p-toluene sulfonate salt of the compound of formula (I).

16. A pharmaceutical composition comprising a compound of formula (I) or its pharmaceutically acceptable salt of any one of claims 1 to 15, and at least one pharmaceutically acceptable carrier, and optionally further comprising a second therapeutic agent.

17. The pharmaceutical composition of claim 16, wherein the second therapeutic agent is an anti-cancer agent.

18. Use of a compound of formula (I) or its pharmaceutically acceptable salt of any one of claims 1 to 15 or a pharmaceutical composition of claim 16 or 17 for the manufacture of a medicament for the prevention and / or treatment of a disease or disorder associated with cereblon protein, wherein the disease or disorder associated with cereblon protein is selected from the group consisting of: a neoplasm, an inflammatory disease, and an autoimmune disease.

19. The use of claim 18, wherein the disease or disorder associated with cereblon protein is selected from the group consisting of: myeloma; myelofibrosis; myeloid disease; myelodysplastic syndrome; previously treated myelodysplastic syndrome; transplantation-related cancer; leukemia; lymphoma; thyroid cancer; melanoma; lung cancer; inflammatory myofibroblastic tumor; colorectal cancer; intestinal cancer; brain glioma; astrocytoma; ovarian cancer; bronchial cancer; prostate cancer; breast cancer; pancreatic cancer; central nervous system cancer; neuroblastoma; neuroglioma; peripheral neuroepithelioma; extramedullary plasmacytoma; plasmacytoma; gastric cancer; gastrointestinal stromal tumor; esophageal cancer; large intestine adenocarcinoma; esophageal squamous cell carcinoma; liver cancer; renal cell carcinoma; bladder cancer; endometrial cancer; uterine cancer; head and neck cancer; brain cancer; oral cancer; sarcoma; urothelial carcinoma; basal cell carcinoma; oral squamous cell carcinoma; cholangiocarcinoma; bone cancer; cervical cancer; skin cancer; Rieger syndrome; chronic obstructive pulmonary disease; asthma; organ or tissue transplant rejection; diabetes; paraneoplastic syndrome; and cachexia-induced multi-organ failure.

20. The use of claim 18, wherein the disease or disorder associated with the cereblon protein is selected from the group consisting of multiple myeloma, plasma cell myeloma, smoldering myeloma, simmering multiple myeloma; acute myelocytic leukemia, chronic myelocytic leukemia, B-cell chronic lymphocytic leukemia, anemia associated with leukemia, acute myeloid leukemia; diffuse large B-cell lymphoma, non-Hodgkin's lymphoma, Hodgkin's lymphoma, anaplastic lymphoma, anaplastic large cell lymphoma, CD20 positive lymphoma, mantle cell lymphoma, primary lymphoma, B-cell lymphoma, relapsed B-cell non-Hodgkin's lymphoma, relapsed diffuse large B-cell lymphoma, relapsed mediastinal large B-cell lymphoma, primary mediastinal large B-cell lymphoma, relapsed transformed non-Hodgkin's lymphoma, refractory B-cell non-Hodgkin's lymphoma, refractory diffuse large B-cell lymphoma, refractory primary mediastinal large B-cell lymphoma, refractory transformed non-Hodgkin's lymphoma; lung adenocarcinoma, lung squamous carcinoma; triple negative breast cancer, sporadic breast cancer and patients with Coudden's disease; rhabdomyosarcoma, various adipose-derived tumors, Ewing's sarcoma / primitive neuroectodermal tumor, and leiomyosarcoma; rheumatoid arthritis, autoimmune encephalomyelitis, ankylosing spondylitis, psoriasis, systemic lupus erythematosus, multiple sclerosis, recurrent oral ulceration, Kawasaki disease, polymyositis / dermatomyositis, Sjogren's syndrome, atopic dermatitis; Crohn's disease and ulcerative colitis, pneumonia, osteoarthritis, synovitis, systemic inflammatory response syndrome, airway inflammation, bronchitis; kidney, heart, lung or tissue transplant rejection; or atherosclerosis.

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