Topical compositions

Abstract

The present invention relates to specific topical compositions comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), butyl octyl salicylate and at least one inorganic UV-filter selected from titanium dioxide and zinc oxide. The compositions exhibit an attractive skin feel and appearance.

Description

[0001] This invention relates to specific topical compositions comprising bis-ethylhexyloxyphenol methoxyphenyl triazine (BEMT), butyl octyl salicylate, and at least one inorganic UV filter selected from titanium dioxide and zinc oxide. The compositions exhibit an appealing skin feel and appearance.

[0002] There is a growing demand for sunscreens with an SPF of 20 or higher to provide effective protection against UV radiation. However, at the same time, such sunscreens should still offer an appealing feel and appearance on the skin.

[0003] Inorganic UV filters, namely micronized (often also called finely powdered) metal oxides such as titanium dioxide or zinc oxide, are particularly useful in sun protection applications due to their ability to increase the sun protection factor (SPF) of formulations across a wide UV spectrum. Furthermore, these inorganic UV filters are generally considered safe for cosmetic use and do not have the sticky feel that is common with most organic UV filters. However, problems still exist associated with the use of such inorganic UV filters. Specifically, the required level of metal oxide powder to achieve an appropriate (and high) SPF level makes the product aesthetically unacceptable, resulting in a heavy and rough feeling on the skin and white / blue residue.

[0004] Although there have been attempts to develop effective sunscreen compositions containing inorganic UV-filters that exhibit reduced skin whitening effects, this problem has not yet been satisfactorily resolved, especially in the case of formulations characterized by high SPF.

[0005] Therefore, there is a continued need to develop new sunscreen formulations containing inorganic UV filters that exhibit reduced skin whitening effects while having a high sun protection factor (SPF 20 or higher), and that do not contain isoamyl 4-methoxycinnamate (INCI: isoamyl p-methoxycinnamate, CAS No. 71617-10-2), (2-ethylhexyl) 4-(dimethylamino)benzoate (INCI: diethylaminohydroxybenzoylhexyl benzoate; CAS No. 302776-68-7), or ethylhexyl 2-cyano-3,3-diphenylacrylate (INCI: octocrylene, CAS No. 6197-30-4).

[0006] The downside of using UV filters that have abandoned their patents (although they have been approved by approval agencies) is that they are not without controversy for a variety of reasons, such as being downgraded by consumer magazines due to potential hormonal activity (e.g., environmental testing), causing discoloration of the formulation, or staining clothing.

[0007] Surprisingly, it has been found that butyl octyl salicylate and / or bis(ethylhexyl)oxyphenol methoxyphenyl triazine can reduce the skin-whitening effect of inorganic UV filters in high SPF formulations that do not contain isoamyl p-methoxycinnamate, hexyl diethylamino hydroxybenzoyl benzoate, and octocrylene. The effect is particularly pronounced when BHB and BEMT are used in combination, with the inorganic filter being titanium dioxide, most preferably a double-coated titanium dioxide comprising an inner silica layer and an outer polydimethylsiloxane coating.

[0008] Therefore, in a first embodiment, the present invention provides a topical sunscreen composition comprising bis(ethylhexyloxyphenol)methoxyphenyltriazine (BEMT), butyloctylsalicylate (BHB), and at least one inorganic UV filter selected from titanium dioxide and zinc oxide, provided that the composition does not contain isoamyl p-methoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate, and octocrylene (any one of these).

[0009] Another subject of the invention relates to a method for reducing the whitening effect caused by inorganic UV-filters selected from titanium dioxide and / or zinc oxide, said inorganic UV-filters being applied to a surface, particularly the skin, in a topical composition comprising bis(ethylhexyloxyphenol)methoxyphenyltriazine, said method comprising the step of adding butyl octyl salicylate to said topical composition and optionally including the step of appreciating said effect. Preferably, said composition does not contain isoamyl p-methoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate, and octocrylene (any one of these).

[0010] In another embodiment, the present invention relates to the use of butyl octyl salicylate to reduce the (skin) whitening effect caused by inorganic UV-filters selected from titanium dioxide and zinc oxide, particularly, said inorganic UV-filters combined with bis(ethylhexyloxyphenol)methoxyphenyltriazine in a topical composition. Preferably, said composition does not contain isoamyl p-methoxycinnamate, hexyl diethylaminohydroxybenzoylbenzoate, or octocrylene.

[0011] The present invention also relates to the use of a combination of butyl octyl salicylate and bis(ethylhexyloxyphenol)methoxyphenyl triazine for reducing the (skin) whitening effect of inorganic UV-filters selected from titanium dioxide and zinc oxide.

[0012] As used herein, the term "topical" should be understood to mean externally applied to a keratinous substance, specifically skin, scalp, eyelashes, eyebrows, nails, mucous membranes, and hair, preferably skin.

[0013] Diethylhexyloxyphenol methoxyphenyl triazine (also referred to herein as BEMT) is also known as 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine (chemical name) or bemotrizinol (INN) (CAS No. 187393-00-6). BEMT acts as a broad-spectrum UV filter that absorbs both UVB and UVA rays. It has two absorption peaks, at 310 nm and 340 nm. BEMT is recommended for use in sunscreens, day care products, lip products (such as BB cream), whitening products, and makeup.

[0014] In all embodiments of the invention, the amount of BEMT in the local composition according to the invention is advantageously selected from the range of 0.4 wt% to 10 wt% based on the total weight of the composition, preferably from the range of 0.4 wt% to 9 wt%, 0.4 wt% to 8 wt%, 0.4 wt% to 7 wt%, 0.4 wt% to 6 wt%, 0.4 wt% to 5 wt%, 0.4 wt% to 4 wt%, 0.4 wt% to 3 wt%, 0.5 wt% to 3 wt%, 0.8 wt% to 9 wt%, 0.8 wt% to 8 wt%, 0.8 wt% to 7 wt%, 0.8 wt% to 6 wt%, 0.8 wt% to 5 wt%, 0.8 wt% to 4 wt%, 0.8 wt% to 3 wt%, for example from the range of 1 wt% to 5 wt%, 1 wt% to 3 wt%, 2 wt% to 5 wt%, or 2 wt% to 4 wt%.

[0015] Butyl octyl salicylate (also referred to as BHB in this article) is also known as 2-butyric acid 2-octyl 2-hydroxybenzoate (CAS No.: 190085-41-7). BHB is commonly used as a solubilizer for some commonly used UV filters (such as oxybenzone or avobenzone) and it can also help improve the SPF rating of sunscreens.

[0016] In all embodiments of the invention, the amount of BHB in the local composition according to the invention is advantageously selected from the range of 0.5 wt% to 10 wt% based on the total weight of the composition, preferably from 0.5 wt% to 9 wt%, 0.5 wt% to 8 wt%, 0.5 wt% to 7 wt%, 0.5 wt% to 6 wt%, 0.5 wt% to 5 wt%, 1 wt% to 9 wt%, 1 wt% to 8 wt%, 1 wt% to 7 wt%, 1 wt% to 6 wt%, 2 wt% to 9 wt%, 2 wt% to 8 wt%, 2 wt% to 6 wt%, for example 2.5 wt% to 5 wt%, 2 wt% to 3 wt%, or 2 wt% to 5 wt%.

[0017] As used herein, the term "inorganic UV filter" refers to any metal oxide particles whose particle size allows for the absorption of UV light and which can therefore be used as UV filters in sunscreen compositions. Such inorganic UV filters are well known to those skilled in the art and are often referred to as micronized or fine titanium dioxide or zinc oxide.

[0018] There are no particular restrictions on the particle size of such inorganic UV filters. Generally, suitable (primary) particle sizes for effective UV light absorption are in the range of 2 nm to 200 nm.

[0019] Unless otherwise specified, the particle size given herein refers to the mean-based particle size distribution Dn50 (also known as Dn0.5) determined by laser diffraction (e.g., using a Horiba LA-960 particle size distribution analyzer or a Malvern Mastersizer 2000 (ISO 13320:2009)).

[0020] In all embodiments of the invention, the amount of inorganic UV-filter in the local composition is preferably selected from the range of 0.5 wt% to 25 wt% based on the total weight of the composition, more preferably from 1 wt% to 20 wt%, and most preferably from 2 wt% to 15 wt%. Other suitable amounts are selected from the ranges of 1 wt% to 7 wt%, 2 wt% to 7 wt%, 3 wt% to 7 wt%, 1 wt% to 6 wt%, 2 wt% to 6 wt%, and 3 wt% to 6 wt%.

[0021] Even more advantageously, the amount of inorganic titanium dioxide UV filter in the partial composition according to the invention is selected from the range of 0.5 wt% to 15 wt% based on the total weight of the composition, preferably from 1 wt% to 15 wt%, more preferably from 2 wt% to 10 wt%, and most preferably from 2 wt% to 6 wt% or from 3 wt% to 6 wt%.

[0022] Even more advantageously, the amount of inorganic zinc oxide UV filter in the partial composition according to the invention is selected from the range of 0.5 wt% to 25 wt% based on the total weight of the composition, preferably from 1 wt% to 15 wt%, more preferably from 2 wt% to 15 wt%, and most preferably from 5 wt% to 15 wt% or from 7.5 wt% to 15 wt%.

[0023] According to the invention, it is advantageous that the inorganic UV filter is surface-coated. Surface coating may comprise providing a hydrophilic or hydrophobic thin layer of inorganic or organic material to the metal oxide particles using methods known per se. According to the invention, different surface coatings may also contain water. As a result of the surface treatment, the metal oxide is endowed with hydrophilicity, amphiphilicity, or hydrophobicity.

[0024] Examples of inorganic surface coatings suitable for the purposes of this invention include alumina (Al₂O₃), aluminum hydroxide Al(OH)₃, alumina hydrate (also known as aluminum oxide, CAS No.: 1333-84-2), sodium hexametaphosphate (NaPO₃)₆, and sodium metaphosphate (NaPO₃). n , silicon dioxide (SiO2) (also known as silica, CAS No.: 7631-86-9), and iron oxide (Fe2O3). These inorganic surface coatings can exist alone, in combination, and / or in combination with organic coating materials, particularly as described below.

[0025] Examples of organic surface coatings suitable for use in this invention include plant or animal aluminum stearate, fatty acids (e.g., stearic acid and lauric acid), dimethyl polysiloxane (also known as polydimethylsiloxane), methyl polysiloxane (polymethylsiloxane), dimethyl silicone oil, triethoxyoctanoyl silane, octyltrimethoxysilane, and cetyl phosphate (e.g., potassium cetyl phosphate), and any mixtures thereof. These organic surface coatings may exist alone, in combination, and / or in combination with inorganic coating materials.

[0026] Titanium dioxide can be in any crystalline or amorphous form. For example, titanium dioxide can be any type of amorphous, rutile, anatase, brookite, or a mixture thereof. Preferably, in all embodiments of the invention, titanium dioxide is in the crystalline form of rutile.

[0027] Furthermore, it is preferred that the zinc oxide is a white powder composed of zinc oxide existing as a wurtzite crystal structure.

[0028] Titanium dioxide particles and pre-dispersions of titanium dioxide particles used in accordance with the present invention, for example, as provided by DSM Naturitional Products Ltd. TX (INCI: titanium dioxide, silicon dioxide, polydimethylsiloxane), Tayca's micro titanium dioxide MT-01, or Ishihara Sangyo Kaisha's TTO-55(C) are commercially available. Also suitable are double-coated titanium dioxide with an inner alumina coating and an outer dimethyl silicone oil coating, such as Eusolex T-2000 from EMDchemicals Inc. / Rona, which is commercially available.

[0029] The zinc oxide particles and pre-dispersions used in accordance with the present invention are, for example, obtained from BASF as Z-Cote or Z-Cote HP1 (2% polydimethylsiloxane coating), from Tayca as MZ-505S (5% polymethylsiloxane coating), or from DSM Nutritional Products Ltd. ZX (2-3.5% triethoxyoctanoyl silane coating) is commercially available.

[0030] In one specific embodiment, the local composition according to the invention comprises a double-coated titanium dioxide and / or coated zinc oxide as an inorganic UV filter, most preferably without any other fine metal oxides.

[0031] Most preferably, in all embodiments of the invention, the titanium dioxide is a double-coated titanium dioxide, and even more preferably a double-coated titanium dioxide having an inner silicon dioxide and an outer organic coating.

[0032] Preferably, the inner silica coating of the double-layer titanium dioxide coating consists of a minimum of 0.5% by weight of inorganic silica (based on titanium dioxide). More preferably, the inner coating consists of 0.5% to 50% by weight, and most preferably 1% to 20% by weight of inorganic silica (based on titanium dioxide).

[0033] The outer coating of the double-layer titanium dioxide coating is preferably selected from organic coating categories, such as silicone oils (e.g., dimethyl silicone oil, polymethylsiloxane, dimethylpolysiloxane, polysiloxane-15), alkylsilanes (e.g., octyltriethoxysilane (octyltrimethoxysilane)), olefinic acids (e.g., stearic acid), or polyols (e.g., glycerol), and can be applied to the titanium dioxide particles by methods known to those skilled in the art (e.g., the method described in FI57124). Preferably, the outer coating is selected from the group consisting of dimethyl silicone oil, polymethylsiloxane, polydimethylsiloxane, polysiloxane-15, stearic acid, and octyltrimethoxysilane. Most preferably, the outer coating is polydimethylsiloxane. Even more preferably, the amount of the outer coating is at least 0.25% by weight based on titanium dioxide. Preferably, the amount of the outer coating is selected from the range of 0.5% by weight to 50% by weight based on titanium dioxide, and most preferably from 0.5% by weight to 10% by weight.

[0034] In all embodiments of the invention, the double-coated titanium dioxide according to the invention preferably has a titanium dioxide content selected from the range of 70-95% by weight and a silicon dioxide content selected from the range of 5-20% by weight, for example preferably a titanium dioxide content selected from the range of 80-90% by weight and a silicon dioxide content selected from the range of 10% to 15% by weight, provided that the total content of titanium dioxide and silicon dioxide is selected from the range of 90-100% by weight.

[0035] Preferably, the double-coated titanium dioxide has an average primary particle size in the range of 2 nm to 100 nm, more preferably in the range of 5 nm to 50 nm, and most preferably in the range of 10 nm to 25 nm, and a secondary particle size between 0.025 μm and 1 μm, for example preferably between 0.05 μm and 0.075 μm.

[0036] Preferably, the suitable double-coated titanium dioxide according to the invention comprises a double-coated rutile titanium dioxide (TiO2) core having silica (inner coating) and polydimethylsiloxane (outer coating), and has a titanium dioxide content of at least 75% by weight, preferably in the range of 82-87% by weight, and a silica content of at least 10% by weight, preferably in the range of 10.5% to 14.5% by weight, and an average particle size distribution D of 25 nm to 100 nm, preferably 40 nm to 80 nm. n 50 (analyzed by laser diffraction using a Malvern Mastersizer 2000), the double-coated titanium dioxide, for example, is from DSM Nutritional Products Ltd. TX (INCI: titanium dioxide, silicon dioxide, polydimethylsiloxane) is commercially available.

[0037] Most preferably, in all embodiments of the invention, zinc oxide is coated with triethoxyoctanoyl silane. Most preferably, the zinc oxide is a white powder consisting of zinc oxide existing as a wurtzite crystal structure, coated with triethoxyoctanoyl silane, having a zinc oxide content of 96-98%, a triethoxyoctanoyl silane content of 2-3.5%, and an average particle size of 90-130 nm (analyzed by laser diffraction using a Malvern Mastersizer 2000).

[0038] In a particularly advantageous embodiment, the composition according to the invention does not contain ethylhexyl salicylate. Even more preferably, the composition according to the invention contains only bis(ethylhexyloxyphenol)methoxyphenyltriazine, butyl octyl salicylate, and at least one inorganic UV filter selected from titanium dioxide and zinc oxide as UV absorbers, i.e., no other UV filter is present in the composition.

[0039] Since the topical compositions according to the invention are intended for topical application, it is well known that they contain physiologically acceptable media, i.e., media compatible with keratinous substances (e.g., skin, mucous membranes, and keratin fibers). Specifically, physiologically acceptable media are cosmetically acceptable carriers.

[0040] As used herein, the term "cosmetically acceptable carrier" refers to all carriers and / or excipients and / or diluents that are routinely used in topical cosmetic compositions, such as, in particular, skin care products.

[0041] The exact amount of the carrier will depend on the actual level of the UV filter and any other optional components (e.g., other active ingredients) that a person skilled in the art would classify as different from the carrier.

[0042] In an advantageous embodiment, the local composition according to the invention comprises 50% to 99%, preferably 60% to 98%, more preferably 70% to 98%, and particularly 80% to 95% of carrier, based on the total weight of the local composition.

[0043] In a particularly advantageous embodiment, the carrier also comprises at least 30% by weight, more preferably at least 40% by weight, and most preferably at least 45% by weight of water, for example, particularly 50% to 90% by weight of water.

[0044] Specifically, the topical composition according to the invention is a cosmetic composition or a pharmaceutical composition, preferably a cosmetic (non-therapeutic) composition.

[0045] In one embodiment, the topical composition according to the invention is applied to the keratinous tissue of a mammal, for example, specifically to human skin or human scalp and hair.

[0046] As used in this application, the term "cosmetic composition" refers to, for example, the composition described in "Kosmetika" in [the context of the application]. Lexikon Chemie, 10th edition 1997, Georg Thieme Verlag Stuttgart, New York, as well as cosmetic compositions disclosed in A. Domsch, "Cosmetic Compositions", Verlag für chemische Industrie (ed. H. Ziolkowsky), 4th edition, 1992.

[0047] Preferred topical compositions according to the present invention are skin care products, decorative products, and functional products.

[0048] Examples of skin care products include, in particular, photoprotective products, anti-aging products, products for treating photoaging, body oils, body lotions, body gels, care creams, skin ointments, skin powders, moisturizing gels, moisturizing sprays, facial and / or body moisturizers, skin tanning products (i.e., compositions for artificial / non-sun tanning and / or browning of human skin), such as tanning creams, and skin brightening products.

[0049] Examples of decorative products include, in particular, lipstick, eyeshadow, mascara, dry and moist cosmetic preparations, blush and / or loose powder.

[0050] Examples of functional formulations are cosmetic or pharmaceutical compositions containing active ingredients, such as, but not limited to, hormone formulations, vitamin formulations, plant extract formulations, anti-aging formulations, and / or antimicrobial (antibacterial or antifungal) formulations.

[0051] In one specific embodiment, the local composition according to the invention is a photoprotective agent (sunscreen product, sunscreen agent), such as sun protection milks, sunscreen lotions, sunscreen creams, sunscreen oils, sunblocks, or tropical creams or day creams with SPF (Sun Protection Factor). Sunscreen creams, sunscreen lotions, and sun protection milks are of particular interest.

[0052] The compositions of the present invention (including a carrier) may contain conventional adjuvants and additives, such as preservatives / antioxidants, fatty substances / oils, organic solvents, siloxanes, thickeners, softeners, emulsifiers, defoamers, aesthetic components (e.g., fragrances), surfactants, fillers, anionic polymers, cationic polymers, nonionic polymers or amphoteric polymers or mixtures thereof, propellants, acidifiers or alkalizers, dyes, colorants / dyes, abrasives, absorbents, chelating agents and / or multivalent chelating agents, essential oils, skin-feeling agents, astringents, pigments, or any other ingredients commonly formulated into such compositions.

[0053] According to the present invention, the compositions according to the present invention may contain other ingredients, such as those for brightening the skin; preventing sunburn; treating hyperpigmentation; preventing or reducing acne, wrinkles, fine lines, atrophy and / or inflammation; chelating agents and / or chelates; fat-reducing and slimming (e.g., phytic acid), firming, moisturizing and revitalizing, sun-protecting, soothing agents, and agents for improving elasticity and skin barrier, and / or additional ultraviolet filtering substances and carriers and / or excipients or diluents traditionally used in topical compositions.

[0054] Unless otherwise specified, the excipients, additives, diluents, etc. mentioned below are applicable to the topical compositions according to the present invention. The necessary amounts of cosmetic and dermatological auxiliaries and additives can be readily determined by a person skilled in the art based on the desired product.

[0055] Additional components can be added to the oil phase, the aqueous phase, or added separately, depending on the situation. Those skilled in the art can easily adjust the addition method.

[0056] Examples of cosmetic excipients, diluents, adjuvants, additives, and active ingredients commonly used in the skin care industry that are suitable for use in the cosmetic compositions of the present invention are described, for example, in, but not limited to, the International Cosmetic Ingredient Dictionary & Handbook by Personal Care (http: / / www.personalcarecouncil.org / ), provided by the Personal Care Products Council, which is accessible online at INFO BASE (http: / / online.personalcarecouncil.org / jsp / Home.jsp).

[0057] In some cases, the cosmetic active ingredients used in this invention may provide more than one benefit or act through more than one mode of action.

[0058] Of course, those skilled in the art will take care to select the optional additional ingredients, adjuvants, diluents and additives and / or their amounts such that the advantageous properties inherently associated with the combination according to the invention are not, or substantially not, adversely affected by one or more of the contemplated additives.

[0059] In all embodiments of the invention, preferred local compositions are emulsions containing an oil phase and an aqueous phase, such as, in particular, O / W, W / O, Si / W, W / Si, O / W / O, W / O / W multiple or Pickering emulsions. The amount of the oil phase (i.e., the phase containing all oils) present in such emulsions is based on the total weight of the composition, preferably at least 10% by weight, for example, in the range of 10% to 60% by weight, preferably in the range of 15% to 50% by weight, and most preferably in the range of 15% to 40% by weight.

[0060] According to one or even a more preferred embodiment, the local composition according to the invention, as outlined herein, is an O / W emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an O / W emulsifier. The preparation of such O / W emulsions is well known to those skilled in the art and is illustrated in the examples.

[0061] In an advantageous embodiment, the O / W emulsifier is a phosphate ester emulsifier. Among preferred phosphate ester emulsifiers is C... 8-10 Alkyl ethyl phosphate, C 9-15 Alkyl phosphates, cetearyl alcohol polyether-2 phosphates, cetearyl alcohol polyether-5 phosphates, cetearyl alcohol polyether-8 phosphates, cetearyl alcohol polyether-10 phosphates, cetearyl phosphates, C6-10 alkanol polyether-4 phosphates, C12-15 alkanol polyether-2 phosphates, C12-15 alkanol polyether-3 phosphates, DEA-cetearyl alcohol polyether-2 phosphates, DEA-cetearyl phosphates, DEA-oleyl alcohol polyether-3 phosphates, cetyl phosphate potassium, decanol polyether-4 phosphates, decanol polyether-6 phosphates, and lauryl alcohol polyether-4 phosphates. A specific phosphate emulsifier according to the present invention is cetyl phosphate potassium, for example, which can be used as... K was purchased from Kaiseraugst, DSM Nutritional Products Ltd.

[0062] Other suitable O / W emulsifiers according to the invention include PEG-30 dihydroxystearate, PEG-4 dilaurate, PEG-8 dioleate, PEG-40 sorbitan peroleate, PEG-7 glyceryl cocoate, PEG-20 amygdalin glyceride, PEG-25 hydrogenated castor oil, glyceryl stearate (and) PEG-100 stearate, PEG-7 palmitate, PEG-8 oleate, PEG-8 laurate, PEG-60 amygdalin glyceride, PEG-20 methylglucose sesquistearate, PEG-40 stearate, PEG-100 stearate, PEG-80 sorbitan peroleate, PEG-7 glyceryl cocoate, PEG-20 methylglucose sesquistearate, PEG-40 stearate, PEG-100 stearate, PEG-80 sorbitan peroleate, PEG-4 ... Saturated sorbitan lauryl ester, stearyl alcohol polyether-2, stearyl alcohol polyether-12, oleyl alcohol polyether-2, cetyl alcohol polyether-2, lauryl alcohol polyether-4, oleyl alcohol polyether-10, oleyl alcohol polyether-10 / polyethylene glycol 10 oleyl ether, cetyl alcohol polyether-10, isostearyl alcohol polyether-20, cetyl stearyl alcohol polyether-20, oleyl alcohol polyether-20, stearyl alcohol polyether-20, stearyl alcohol polyether-21, cetyl alcohol polyether-20, isocetyl alcohol polyether-20, lauryl alcohol polyether-23, stearyl alcohol polyether-100, glyceryl stearate citrate, glyceryl stearate (self-emulsifying), stearic acid, salts of stearic acid, polyglycerol-3-methylglucose distearate. Other suitable emulsifiers include sorbitan oleate, sorbitan sesquioleate, sorbitan isostearate, sorbitan trioleate, lauryl glucoside, decyl glucoside, sodium stearoyl glutamate, sucrose polystearate, and hydrated polyisobutylene. Additionally, one or more synthetic polymers can be used as emulsifiers. Examples include PVP eicosene copolymers, acrylates / C... 10-30 Alkyl acrylate crosspolymers, acrylate / stearyl alcohol polyether-20 methacrylate copolymers, PEG-22 / dodecyl glycol copolymers, PEG-45 / dodecyl glycol copolymers, and mixtures thereof.

[0063] Another particularly suitable class of O / W emulsifiers is nonionic self-emulsifying systems derived from olive oil, such as olive oil cetyl ester and dehydrated sorbitan olive oil ester (chemical composition: dehydrated sorbitan ester and cetearyl ester of olive oil fatty acids) sold under the trade name OLIVEM 1000.

[0064] Another suitable option is a commercially available polymer emulsifier, such as hydrophobically modified polyacrylic acid, for example, acrylate / C10-30 alkyl acrylate crosspolymers, which are marketed under trade names. TR-1 and TR-2 are commercially available from Noveon.

[0065] Another particularly suitable class of emulsifiers are polyglycerol esters or fatty acid diesters, also known as polyglycerol esters / diesters (i.e., polymers in which one or more fatty acids are combined with polyglycerol through esterification), for example, commercially available in Evonik as Isolan GPS [INCI name: polyglycerol-4 diisostearate / polyhydroxystearate / sebacate (i.e., diester of a mixture of isostearic acid, polyhydroxystearate and sebacate with polyglycerol-4)], or commercially available in Cognis as Dehymuls PGPH (INCI polyglycerol-2-2 dihydroxystearate).

[0066] Also suitable are polyalkylene glycol ethers, such as Brij 72 (polyoxyethylene (2) stearyl ether) or Brij 721 (polyoxyethylene (21) stearyl ether, for example, available at Croda).

[0067] The particularly advantageous O / W emulsifiers according to the invention are one or more of the following: polyglycerol-3-methylglucoside distearate, lauryl glucoside (and) polyglycerol-2-dipolyhydroxystearate, glyceryl stearate citrate, sodium cetearyl sulfate, cetearyl glucoside; polyglycerol-6-stearate (and) polyglycerol-6-behenate, cetyl oleoresin (and) sorbitan oleoresinate, and florfenicol. Peanutyl alcohol (and) behenyl alcohol (and) arachidonic acid glucoside, cetearyl alcohol (and) coco glucoside, coco glucoside (and) cocoyl alcohol, PEG-100 stearate (and) glyceryl stearate, sodium stearoyl glutamate, stearyl alcohol polyether-20, stearyl alcohol polyether-21, stearyl alcohol polyether-25, stearyl alcohol polyether-2, cetearyl alcohol polyether-25 and cetearyl alcohol polyether-6 (all listed by their INCI names).

[0068] If the composition contains potassium cetyl phosphate as an emulsifier, it is particularly preferred according to the present invention.

[0069] The at least one O / W or Si / W type emulsifier is preferably used in an amount of 0.5 wt% to 10 wt% based on the total weight of the composition, for example, particularly in the range of 0.5 wt% to 5 wt%, for example, most particularly in the range of 0.5 wt% to 4 wt%.

[0070] Suitable W / O or W / Si emulsifiers according to the present invention are: polyglycerol-2-dipolyhydroxystearate, PEG-30 dipolyhydroxystearate, cetyl polydimethylsiloxane copolyol, polyglycerol-3-diisostearate polyglycerol ester of oleic acid / isostearic acid, polyglycerol-6-hexaricinolate, polyglycerol-4-oleate, polyglycerol-4-oleate / PEG-8 propylene glycol cocoate, magnesium stearate, sodium stearate, potassium laurate, potassium ricinoleate, sodium cocoate, sodium tallow, potassium castorate, sodium oleate, and mixtures thereof. Other suitable W / Si emulsifiers are lauryl polyglycerol-3, polydimethylsiloxane-ethyl dimethylpolysiloxane and / or PEG-9 polydimethylsiloxane-ethyl dimethylpolysiloxane and / or cetyl PEG / PPG-10 / 1 dimethylpolysiloxane and / or PEG-12 dimethylpolysiloxane crosspolymer and / or PEG / PPG-18 / 18 dimethylpolysiloxane. The at least one W / O emulsifier is preferably used in an amount of about 0.001% to 10% by weight, more preferably 0.2% to 7% by weight, relative to the total weight of the composition.

[0071] According to the invention, it is advantageous if the composition of the invention also does not contain polyethylene glycol, polyethylene glycol ether, and polyethylene glycol ester (so-called PEG derivatives).

[0072] Furthermore, the local compositions according to the invention advantageously contain at least one co-surfactant, for example selected from the group consisting of monoglycerides and diglycerides and / or fatty alcohols. The co-surfactant is typically used in an amount selected from the total weight of the composition, ranging from 0.1% to 10% by weight, particularly from 0.5% to 7% by weight, and most particularly from 1% to 5% by weight. Particularly suitable co-surfactants are selected from the following list: alkyl alcohols, such as cetyl alcohol (Lorol C16, Lanette 16), cetearyl alcohol (Lanette O), stearyl alcohol (Lanette 18), behenyl alcohol (Lanette 22), glyceryl stearate, glyceryl myristate (Estol 3650), hydrogenated coconut oil glyceride (Lipocire Na10), and mixtures thereof.

[0073] In all embodiments of the invention, it is particularly advantageous if the composition further comprises cetyl alcohol, stearyl alcohol and / or glyceryl stearate, preferably stearyl alcohol.

[0074] Advantageous embodiments of the compositions of the present invention also include embodiments in which the composition comprises one or more oils selected from the group consisting of: butanediol dioctanoate / didecanoate, phenethyl benzoate, C 12 -C 15 Alkyl benzoate, dibutyl adipate; diisopropyl sebacate, dioctyl carbonate, di-C tartaric acid 12-13 Alkyl esters, butyl octyl salicylate, diethylhexyl eugenol malonate, hydrogenated castor oil dimerates, glyceryl triheptanoate, C-lactic acid 12-13 Alkyl esters, C16-17 alkyl benzoates, propylheptaethyl octanoate, caprylic / capric triglyceride, diethylhexyl 2,6-naphthalenedicarboxylate, octyl dodecyl alcohol, and ethylhexyl cocoate. Preferably, the compositions according to the invention comprise dibutyl adipate, dioctyl carbonate, and C as oils. 12 -C 15 Alkyl benzoates, octyl carbonate, capric / capric triglycerides, and mixtures thereof, most preferably dibutyl adipate, dioctyl carbonate, and / or C 12 -C 15 Alkyl benzoate.

[0075] In another advantageous aspect of the invention, the partial compositions of the invention further comprise a preservative and / or a preservative accelerator, preferably selected from the group consisting of: ethanol, phenoxyethanol, ethylhexylglycerin, hexylglycerin, caprylic glyceride, 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, 2-methyl-1,3-propanediol, propylene glycol, p-hydroxyacetophenone, and mixtures thereof, most preferably selected from the group consisting of phenoxyethanol and ethylhexylglycerin, and mixtures thereof. The preservative or preservative accelerator, when present, is preferably used in an amount of 0.01% to 2% by weight, more preferably 0.05% to 1.5% by weight, and most preferably 0.1% to 1.0% by weight, based on the total weight of the composition.

[0076] According to the present invention, it is advantageous if the formulation comprises one or more alkyldiols selected from the group consisting of 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, and 2-methyl-1,3-propanediol.

[0077] If the compositions of the present invention comprise ethanol, p-hydroxyacetophenone phenoxyethanol and / or ethylhexylglycerin, then the present invention is further advantageous.

[0078] In another advantageous aspect, the topical compositions according to the invention are free from any parabens, benzyl chloride, piroctone ethanolamine, lauroyl arginine, methylisothiazolinone, chloromethylisothiazolinone, bromonitol, benzalkonium chloride, formaldehyde-releasing compounds, salicylic acid, triclosan, DMDM ​​hydantoin, chlorphenesin, and IPBC (iodopropinylbutyl carbamate).

[0079] The topical compositions according to the present invention may also contain one or more skin-soothing and softening emollients. Examples of emollients include silicones (polydimethylsiloxane, cyclomethicone), vegetable oils (grape seed oil, sesame seed oil, jojoba oil, etc.), butters (cocoa butter, shea butter), and petrolatum derivatives (petroleum jelly, mineral oil).

[0080] In another aspect, the local composition of the present invention may comprise one or more fragrance agents selected from limonene, citral, linalool, α-isomethylionone, geraniol, citronellol, 2-isobutyl-4-hydroxy-4-methyltetrahydropyran, 2-tert-pentylcyclohexyl acetate, 3-methyl-5-phenyl-1-pentanol, 7-acetyl-1,1,3,4,4,6-hexamethyltetrahydronaphthalene, adipate, cinnamaldehyde, amyl salicylate, α-pentylcinnamaldehyde, α-methylionone, butylphenylmethylpropionaldehyde, cinnamaldehyde, pentylcinnamyl alcohol, anisole, benzoin, benzene Methanol, benzyl benzoate, benzyl cinnamate, benzyl salicylate, bergamot oil, bitter orange oil, butylphenyl methylpropionaldehyde, cardamom oil, cedrol, cinnamaldehyde, cinnamyl alcohol, methyl crotonate citronellol, citrus oil, coumarin, diethyl succinate, ethyl linalool, eugenol, tree moss extract, oakmoss extract, farnesol, guaiac oil, hexyl cinnamaldehyde, hexyl salicylate, hydroxycitronellol, lavender oil, lemon oil, linalool acetate, orange peel oil, menthol PCA ester, methyl heptenone, nutmeg oil, rosemary oil, sweet orange oil, terpineol, tonka bean oil, triethyl citrate, vanillin.

[0081] The compositions of the present invention may advantageously include a moisturizing agent. A moisturizing agent is a compound or mixture of compounds that imparts to the cosmetic composition a reduction in stratum corneum water loss (also known as transepidermal water loss, TEWL) and / or a positive effect on the quality of stratum corneum hydration after application or distribution to the skin surface.

[0082] Non-limiting examples of advantageous moisturizers used in this invention include glycerin, lactic acid and / or lactates, especially sodium lactate, butylene glycol, 1,2-propanediol, biosaccharide gum-1, soybean, ethylhexyloxyglycerin, pyrrolidone carboxylic acid, and urea. A further advantage is the use of polymeric moisturizers derived from the group of water-soluble and / or water-swellable and / or water-gelatable polysaccharides. Particularly advantageous are, for example, hyaluronic acid, deacetylated chitin, and / or fucose-rich polysaccharides, which are registered in Chemical Abstracts under registration number 178463-23-5 and can be used, for example, under the name... Purchased from SOLABIA SA. Moisturizers can also be advantageously used as active anti-wrinkle ingredients to protect against skin changes that occur during skin aging.

[0083] The cosmetic compositions of the present invention may advantageously (though not mandatory) further comprise fillers that have, for example, further improved the sensory and cosmetic properties of the formulation and evoked or enhanced, a velvety or silky skin feel. In the context of the present invention, advantageous fillers are starches and starch derivatives (e.g., tapioca starch, distarch phosphate, aluminum octenyl succinate starch, or sodium octenyl succinate starch, etc.), Valvance pigments (e.g., Valvance Touch 210 or 250) that have neither a primary UV filter effect nor a coloring effect, and / or... (CAS No. 7631-86-9) and / or talc and / or polyethylene, nylon and dimethylsilyl alkyl silica.

[0084] The aqueous phase of the compositions of the present invention may advantageously contain conventional cosmetic adjuvants, such as alcohols, particularly low-carbon alcohols, preferably ethanol and / or isopropanol, or low-carbon polyols, and their ethers, preferably 1,2-propanediol, glycerin; electrolytes; sunscreen agents; and particularly one or more thickeners, which may advantageously be selected from the group consisting of: silica, aluminum silicate, polysaccharides and / or their derivatives, such as hyaluronic acid, xanthan gum, hydroxypropyl methylcellulose, and particularly advantageously selected from the group consisting of: polyacrylates, preferably polyacrylates selected from the group known as carbomers, examples being carbomers of types 980, 981, 1382, 2984 and 5984, which are used alone or in combination in each case. Other advantageous thickeners according to the invention are those having INCI names such as acrylate / C10-30 alkyl acrylate crosspolymers (e.g., Pemulen TR 1, Pemulen TR 2, Carbomer 1328 from NOVEON), as well as those thickeners such as Aristoflex AVC (INCI: ammonium acryloyl dimethyl taurate / VP copolymer) and Simugel NS (INCI: hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymer and squalane and polysorbate 60).

[0085] The composition is preferred according to the invention if it comprises xanthan gum, crosslinked acrylate / C10-C30 alkyl acrylate polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer and / or vinylpyrrolidone / hexadecene copolymer, preferably xanthan gum and / or hydroxyethyl acrylate / sodium acryloyldimethyl taurate.

[0086] In addition to bis(ethylhexyloxyphenol)methoxyphenyltriazine (BEMT)BHB and inorganic UV filters, one or more additional UV filters may be present in the local compositions according to the invention. These UV filters are, in particular (INCI name) methylene bis-benzotriazolyltetramethylbutylphenol, terphenyltriazine, phenylbenzimidazole sulfonic acid, dimethylsiloxane diethyl ester of benzylmethylene malonate, 4-methylbenzyl camphor, ethylhexyl salicylate, homosalate, ethylhexyltrione, diethylhexylbutamidotriazine ketone, butyl methoxydibenzoylmethane, disodium phenyldibenzimidazole tetrasulfonate, and oxybenzophenone, but are not limited thereto.

[0087] However, in an advantageous aspect of the invention, the partial compositions according to the invention further do not contain (i.e., also do not contain) 3-(4-methylbenzyl)camphor (INCI: 4-methylbenzyl camphor), 2-hydroxy-4-methoxybenzophenone (INCI: oxybenzophenone) and / or ethylhexyl methoxycinnamate.

[0088] The local composition of the present invention uses an astonishingly small amount of ultraviolet filter.

[0089] In another aspect, the composition may have an SPF of at least 20, preferably at least 30.

[0090] Advantageously, according to the invention, the composition of the invention comprises a film-forming agent. In the sense of the invention, a film-forming agent is a substance having various compositions and characterized by the following properties: when the film-forming agent is dissolved in water or other suitable solvent, when the solution is subsequently applied to the skin, the film-forming agent forms a film after the solvent evaporates, which essentially serves to fix the filter onto the skin and thereby increase the water resistance of the product.

[0091] Choosing film-forming agents from the polyvinylpyrrolidone (PVP)-based polymer family is particularly advantageous.

[0092] Particularly preferred are copolymers of vinylpyrrolidone, such as, for example, PVP hexadecene copolymer and PVP eicosene copolymer, which are available from GAF Chemicals Corporation under the trade names Antaron V216 and Antaron V220.

[0093] Other polymeric film-forming agents are also advantageous, such as sodium polystyrene sulfonate, available from National Starchand Chemical Corp. under the trade name Flexan 130; and / or polyisobutylene, available from Rewo under the trade name Rewopal PIB1000. Examples of other suitable polymers are polyacrylamide (Seppigel 305), polyvinyl alcohol, PVP, PVP / VA copolymer, polyethylene glycol, and acrylate / octylacrylamide copolymer (Dermacryl 79). Also advantageous is the use of hydrogenated castor oil dimer dioleate (CAS 646054-62-8, INCI hydrogenated castor oil dimer dioleate), available from Kokyu Alcohol Kogyo under the name Risocast DA-H; or PPG-3 benzyl ether myristate (CAS 403517-45-3), available from Croda Chemicals under the trade name Crodamol STS.

[0094] The pH of the topical composition according to the invention is generally in the range of 3 to 10, preferably in the range of 4 to 8, and most preferably in the range of 4 to 7. The pH can be readily adjusted as needed using a suitable acid (e.g., citric acid) or base (e.g., NaOH) according to standard methods in the art.

[0095] According to the present invention, the compositions of the present invention are used for protection against skin aging (especially protection against skin aging caused by ultraviolet radiation) and as sunscreen compositions.

[0096] Finally, the subject of this invention is a method for cosmetic treatment of keratinous substances, particularly the skin, wherein a composition as defined herein is applied to said keratinous substance, particularly the skin. This method is particularly suitable for protecting the skin from the adverse effects of ultraviolet radiation, such as, in particular, sunburn and / or photoaging, while simultaneously reducing the skin-whitening effects of inorganic UV filters selected from the group consisting of titanium dioxide and / or zinc oxide.

[0097] The following examples are provided to further illustrate the compositions and effects of the present invention. These examples are merely illustrative and are not intended to limit the scope of the invention in any way.

[0098] Experimental Section

[0099] 1. Example 1

[0100] The cream formulations listed in Table 1a have been prepared. Subsequently, the creams were applied to Leneta cards with a film thickness of 60 μm using a rake and a spreading speed of 10 mm / s. The following steps were performed:

[0101] Following this, the whitening effect was assessed by measuring the L value (4 cards per formulation, 3 points measured on each card: 12 values / formulation). L value explanation: The higher the value, the whiter / more bluish the film.

[0102] Table 1a: Formulation

[0103]

[0104]

[0105] *DSM sunscreen enhancer TM

[0106] Table 1b: Results of the skin whitening test

[0107] Reference-1 This invention-1 Average L value before washing 34.7 33.6 Compared to reference whitening, it reduces - -3.2％

[0108] As can be seen from Table 2, the addition of BHB reduces the whitening effect of sunscreens containing BEMT and inorganic UV filters.

[0109] 2. Example 2

[0110] The formulations (O / W emulsions) outlined in Table 2 were prepared according to standard methods in the art. The soaping effect on Leneta Black Cards was then tested according to the methods outlined below:

[0111] - Apply 300mg of cream to the Leneta black card;

[0112] - Use a 90mm applicator blade to apply the cream using the internally developed applicator (speed: 10mm / s) to achieve a uniform film thickness;

[0113] -LAB was measured immediately after application using a Minolta CR-300 colorimeter, with 3 measurement points on each card (4 cards were prepared);

[0114] - Calculate and compare the average L values.

[0115] Table 2

[0116]

[0117] *DSM sunscreen enhancer

[0118] As can be seen from Table 2, the combination of BEMT, BHB and TiO2 micro pigments according to the present invention results in a significant decrease in the L value, thereby reflecting a decrease in the whitening effect of the composition.

[0119] 3. Example 3

[0120] The formulations (O / W emulsions) outlined in Table 3 were prepared according to standard methods in the art. The whitening effect on Leneta Black Cards was then tested according to the methods outlined below:

[0121] - Apply 300mg of cream to the Leneta black card (use 3 cards for each formulation);

[0122] - Use a 60mm applicator blade to apply the cream through the applicator (speed: 10mm / s) to obtain a uniform film thickness;

[0123] -LAB was measured using a Minolta CR-300 colorimeter, with 3 measurement points on each card;

[0124] - Calculate and compare the average L values.

[0125] Table 3

[0126]

[0127] *DSM sunscreen enhancer

[0128] As can be seen from Table 3, the combination of BEMT, BHB and ZnO micro pigments according to the present invention results in a significant decrease in the L value, thereby reflecting a decrease in the whitening effect of the composition.

Claims

1. A topical composition comprising bis(ethylhexyloxyphenol)methoxyphenyltriazine, butyl octyl salicylate, and at least one inorganic UV filter selected from titanium dioxide and zinc oxide, provided that the composition does not contain isoamyl p-methoxycinnamate, hexyl diethylaminohydroxybenzoyl benzoate, and ethylhexyl 2-cyano-octocrylene.

2. The topical composition according to claim 1, wherein the amount of bis(ethylhexyloxyphenol)methoxyphenyltriazine is selected from the range of 0.4% by weight to 10% by weight.

3. The topical composition according to claim 1 or 2, wherein the composition comprises butyl octyl salicylate in an amount selected from 0.5% to 10% by weight based on the total weight of the composition.

4. The topical composition according to claim 1 or 2, wherein the composition comprises, based on the total weight of the composition, an amount selected from the range of 0.5% to 25% by weight of the inorganic UV filter.

5. The topical composition according to claim 1 or 2, wherein the inorganic UV filter is surface-coated.

6. The topical composition according to claim 1 or 2, wherein the inorganic UV filter is selected from the group consisting of: double-coated titanium dioxide having an inner silica and an outer polydimethylsiloxane coating; zinc oxide coated with triethoxyoctanoylsilane; and mixtures thereof.

7. The topical composition according to claim 1 or 2, wherein the composition is an O / W emulsion comprising an oil phase dispersed in an aqueous phase in the presence of an O / W emulsifier.

8. The topical composition according to claim 1 or 2, wherein the composition comprises butanediol, dioctanoate / didecanoate, phenethyl benzoate, and C-benzoic acid. 12 -C 15 Alkyl esters, dibutyl adipate, diisopropyl sebacate, dioctyl carbonate, di-C tartaric acid 12-13 Alkyl ester, diethylhexyl eugenol malonate, hydrogenated castor oil dimer, triheptanyl glycerol, C-lactic acid 12-13 Alkyl esters, benzoic acid C 16-17 One or more of the following: alkyl ester, propylheptaethyl octanoate, caprylic / decanoic acid triglyceride, diethylhexyl 2,6-naphthalenedicarboxylate, octyldodecanool, and ethylhexyl cocoate.

9. The topical composition according to claim 1 or 2, wherein the composition comprises one or more of ethanol, p-hydroxyacetophenone, phenoxyethanol, and ethylhexylglycerin.

10. The topical composition according to claim 1 or 2, wherein the composition comprises xanthan gum, crosslinked acrylate / acrylic acid C 10 -C 30 One or more of alkyl ester polymers and hydroxyethyl acrylate / sodium acryloyl dimethyl taurate copolymers.

11. The topical composition according to claim 1 or 2, wherein the composition comprises one or more of cetyl alcohol, cetearyl alcohol, stearyl alcohol and glyceryl stearate.

12. The partial composition according to claim 1 or 2, wherein the composition comprises one or more alkane diols selected from the group consisting of: 1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-decanediol, propylene glycol, and 2-methyl-1,3-propanediol.

13. The topical composition according to claim 1 or 2, wherein the composition comprises 1,2-propanediol.

14. The topical composition according to claim 1 or 2, wherein the composition has an SPF of at least 20.

15. A method for reducing the whitening effect caused by an inorganic UV filter selected from titanium dioxide and / or zinc oxide, said inorganic UV filter being applied to a surface in a topical composition containing bis(ethylhexyloxyphenol)methoxyphenyltriazine, said method comprising the step of adding butyl octyl salicylate to said topical composition.

16. The combination of butyl octyl salicylate and bis(ethylhexyloxyphenol) methoxyphenyl triazine is used to reduce the whitening effect of inorganic UV filters selected from titanium dioxide and zinc oxide.

17. The combination of butyl octyl salicylate and bis(ethylhexyloxyphenol) methoxyphenyl triazine is used to reduce the skin whitening effect of inorganic UV filters selected from titanium dioxide and zinc oxide.

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