A fungicide and a germicidal wet wipe

Abstract

The present application discloses a bactericide and a bactericidal wet wipe, relating to the technical field of bactericides. The bactericide in the present application uses lactic acid as the main bactericidal component, and uses a pH buffer to keep its pH within a lower value range to effectively exert the bactericidal effect of lactic acid, and uses a chelating agent and a humectant to further improve the bactericidal effect of lactic acid. The bactericide in the present application and the bactericidal wet wipe containing the same have excellent bactericidal effects, little irritation, no odor or do not affect the fragrance of fragrance components, and the preparation method is simple, which is convenient for industrial production and popularization and application.

Description

Technical Field

[0001] This application relates to the technical field of fungicides, and particularly relates to a fungicide and a bactericidal wet wipe. Background Art

[0002] Currently, there have been many studies on fungicides. For example, patent CN115400158A discloses a disinfectant prepared from ethanol, traditional Chinese medicine extract, quaternary ammonium salt type fungicide and distilled water. Especially when it contains 2% (mass concentration) of Cynanchum atratum Bunge extract and 0.1% (mass concentration) of benzalkonium chloride, it has excellent bactericidal spectral properties and stability; patent CN104886110A discloses a disinfectant composed of chlorhexidine acetate, other cationic surfactants, ethanol and water, which can quickly kill bacteria such as Escherichia coli, Salmonella, Streptococcus, Staphylococcus aureus, etc. These disinfectants mostly use cationic surfactants, alcohol, etc. as fungicides, which have strong irritation, strong odor or will affect the fragrance of further added fragrance components. Therefore, it is necessary to develop a fungicide with low irritation, low odor or not affecting the fragrance of fragrance components and excellent bactericidal effect. Summary of the Invention

[0003] Based on the defects existing in the prior art, the purpose of this application is to provide a fungicide and a bactericidal wet wipe. The fungicide not only has excellent bactericidal effect, but also has low irritation, low odor or does not affect the fragrance of fragrance components.

[0004] To achieve the above purpose, in the first aspect, this application provides a fungicide, which contains the following components in mass fractions: 2.5% - 10% of lactic acid, 0.1% - 5% of pH buffer, 0.01% - 2% of chelating agent, and 0.1% - 5% of humectant.

[0005] The fungicide uses lactic acid as the main bactericidal component. Lactic acid molecules can enter bacterial cells through the cell membrane by free diffusion, bind to proteins to inactivate them, affect intracellular metabolic activities, and then cause bacteria to die. The lower the external pH value, the more and faster lactic acid molecules will diffuse into bacterial cells; to achieve efficient sterilization, it is necessary to control the pH value of the fungicide to be as low as possible. However, simply adding acid to adjust the pH will make the pH of the fungicide easily affected by the environmental pH, thus affecting its bactericidal effect. By adding an appropriate amount of pH buffer in the fungicide, not only the pH of the fungicide is within a lower value range, but also the pH of the fungicide is not easily affected by the environment. The chelating agent can chelate calcium, magnesium and other ions in the bacterial cell membrane, make lactic acid pass through the cell membrane more quickly, further improve the bactericidal effect, and help to improve the broad-spectrum property of the fungicide. In addition, the inventor unexpectedly found that adding an appropriate amount of humectant in the fungicide can further improve the bactericidal effect, and the humectant can cooperate with the chelating agent to improve the bactericidal effect.

[0006] The bactericide not only has a very good bactericidal effect, but also the lactic acid is derived from plants and is commonly used as a food additive, odorless, ensuring that the bactericide has little irritation, little odor or does not affect the fragrance of fragrance components.

[0007] The mass fraction of the chelating agent in the bactericide is in the range of 0.01% to 2%, such as 0.05%, 0.1%, 0.5%, 1%, 1.5%, 1.8% or any numerical range formed by any two of the above values. Preferably, the mass fraction of the chelating agent in the bactericide is 0.05% to 1% to further improve the bactericidal effect of the bactericide at a lower cost.

[0008] The chelating agent in the bactericide can optionally include at least one of hydroxyethane diphosphonic acid, tetrasodium glutamate diacetate, ethylenediaminetetraacetic acid, ethylenediaminetetraacetate, octanohydroxamic acid, etc., but the selection is not limited thereto. As an example, the ethylenediaminetetraacetate includes at least one of disodium ethylenediaminetetraacetate, tetrasodium ethylenediaminetetraacetate, etc. Preferably, the chelating agent includes hydroxyethane diphosphonic acid. Compared with other chelating agents, hydroxyethane diphosphonic acid can make the bactericide obtain a better bactericidal effect.

[0009] The mass fraction of the polyol humectant in the bactericide is in the range of 0.01% to 5%, such as 0.05%, 0.1%, 0.5%, 1%, 1.5%, 2%, 2.5%, 3.5%, 4.5%, 4.8% or any numerical range formed by any two of the above values. Preferably, the mass fraction of the polyol humectant in the bactericide is 0.1% to 2% to further improve the bactericidal effect of the bactericide at a lower cost.

[0010] The polyol humectant in the bactericide can optionally include at least one of glycerol, caprylyl glycol, butanediol, dipropylene glycol, hexylene glycol, etc., but the selection is not limited thereto.

[0011] The mass fraction of lactic acid in the bactericide is in the range of 2% to 10%, such as 2.5%, 3.5%, 4.5%, 5.5%, 6.5%, 7.5%, 8.5%, 9.5% or any numerical range formed by any two of the above values. Preferably, the mass fraction of lactic acid in the bactericide is 3% to 6% to further improve the bactericidal effect at a lower cost.

[0012] The mass fraction of the pH buffer in the bactericide is in the range of 0.1% to 5%, such as 0.3%, 0.6%, 1%, 2%, 3%, 4%, 4.5% or any numerical range formed by any two of the above values. Preferably, the mass fraction of the pH buffer in the bactericide is 0.5% to 2% to keep the pH value of the bactericide within a lower value range at a lower cost.

[0013] The pH buffer in the bactericide may optionally include at least one pH buffer system such as citric acid / sodium citrate, citric acid / potassium citrate, dihydrogen phosphate, phosphoric acid / triethylamine, etc., but the selection is not limited thereto. The most suitable buffering range of the citric acid / sodium citrate buffer system is closer to the high-efficiency bactericidal pH range of lactic acid. Preferably, the pH buffer includes citric acid / sodium citrate.

[0014] The bactericide may also contain other functional auxiliaries such as fragrances, preservatives, etc.

[0015] The bactericide also contains a solvent. The solvent may optionally include one of water, ethanol, etc. Preferably, the solvent is water to reduce the irritation and odor of the bactericide.

[0016] The preparation method of the bactericide includes the following steps: mixing each component evenly.

[0017] There is no specific limitation on the form of the bactericide. As an example, the bactericide is a spray, etc.

[0018] When the bactericide is used, it can be brought into contact with the surface of the object to be sterilized by wiping, spraying, pouring, etc. to achieve sterilization. For example, spraying in the air to sterilize the air, and wiping, spraying, pouring, etc. to sterilize human skin, animal skin, furniture, instruments, etc.

[0019] In a second aspect, the present application also provides a sterilizing wet wipe containing the bactericide. The sterilizing wet wipe has a good bactericidal effect due to containing the bactericide, and at the same time has low irritation, low odor or does not affect the fragrance of the fragrance component.

[0020] There is no specific limitation on the preparation method of the sterilizing wet wipe. As an example, mixing the bactericide with a carrier to obtain the sterilizing wet wipe. Among them, there is no specific limitation on the carrier of the sterilizing wet wipe, and non-woven fabric, etc. can be selected.

[0021] Compared with the prior art, the beneficial effects of the present application are as follows:

[0022] (1) The bactericide of the present application uses lactic acid as the main bactericidal component, and uses a pH buffer to keep its pH within a lower value range to effectively exert the bactericidal effect of lactic acid, and uses a chelating agent and a humectant to further synergistically improve the bactericidal effect of lactic acid;

[0023] (2) The bactericide and the sterilizing wet wipe of the present application have excellent bactericidal effects, low irritation, low odor or do not affect the fragrance of the fragrance component, and the preparation method is simple, which is convenient for industrial production and popularization and application. Specific embodiments

[0024] To better illustrate the purpose, technical solution and advantages of the present application, the present application will be further described below in conjunction with specific embodiments and comparative examples. The purpose is to understand the content of the present application in detail, rather than a limitation to the present application. All other embodiments obtained by those of ordinary skill in the art without creative efforts fall within the protection scope of the present application. The experimental reagents and instruments involved in the implementation of the present application are all common ordinary reagents and instruments unless otherwise specified.

[0025] Each of the embodiments and comparative examples provides a bactericide. The compositions of these bactericides are shown in Tables 1 to 4, and the preparation methods all include the following steps:

[0026] 1) Start stirring, add deionized water, chelating agent and pH buffer to the reaction kettle, and stir until completely dissolved;

[0027] 2) Add lactic acid to the reaction kettle and stir until completely dissolved;

[0028] 3) Add glycerol to the reaction kettle and stir until completely dissolved.

[0029] 4) Add daily-use essence and preservative to the reaction kettle and stir until completely dissolved to obtain the corresponding bactericide.

[0030] Table 1

[0031]

[0032]

[0033] Table 2

[0034]

[0035] Table 3

[0036]

[0037] Table 4

[0038]

[0039] Mix the bactericides obtained in each of the embodiments and comparative examples with non-woven fabric at a ratio of 2 times the liquid content (i.e., the mass of the bactericide is 2 times the mass of the non-woven fabric) to obtain bactericidal wet wipes. Test the bactericidal effects of each bactericidal wet wipe. The specific test method is as follows: Refer to Appendix C of CB 15979-2002, the number of Staphylococcus aureus colonies is 7×10 7 cfu / piece, the number of Escherichia coli colonies is 7×10 7 cfu / piece, the action time is 2 minutes, and the test bacteria are Escherichia coli and Staphylococcus aureus. The test results are shown in Table 5.

[0040] Table 5

[0041]

[0042]

[0043] As can be seen from Table 5, the germicidal wet wipes of each embodiment of the present application all have very good germicidal effects. In addition, they have little irritation, no ethanol smell, and will not affect the fragrance of the essence.

[0044] Comparing Example 2 with Comparative Examples 1-3, it can be seen that the chelating agent and the humectant will synergistically improve the germicidal effect of the bactericide.

[0045] Comparing Examples 1-5, it can be seen that the content of the chelating agent in the bactericide will affect the germicidal effect. Preferably, the mass fraction of the chelating agent in the bactericide is 0.05% - 1%, so as to obtain a better germicidal effect at a lower cost. Comparing Example 2 with Examples 6-8, it can be seen that compared with tetrasodium glutamate diacetate, ethylenediaminetetraacetic acid, octanoyl hydroxamic acid, etc., hydroxyethylidene diphosphonic acid can make the bactericidal effect of the bactericide better.

[0046] Comparing Example 2 with Examples 9-12, it can be seen that the content of the humectant in the bactericide will affect the germicidal effect. Preferably, the mass fraction of the humectant in the bactericide is 0.1% - 2%, so as to obtain a better germicidal effect at a lower cost.

[0047] Comparing Example 2 with Examples 17-20, it can be seen that the content of lactic acid in the bactericide will affect the germicidal effect. Preferably, the mass fraction of lactic acid in the bactericide is 3% - 6%, so as to obtain a better germicidal effect at a lower cost.

[0048] Comparing Example 2 with Examples 21-24, it can be seen that the content of the pH buffer in the bactericide will affect the germicidal effect. Preferably, the mass fraction of the pH buffer in the bactericide is 0.5% - 2%, so as to obtain a better germicidal effect at a lower cost. Comparing Example 2 with Examples 25-26, it can be seen that compared with dihydrogen phosphate and phosphoric acid / triethylammonium, citric acid / sodium citrate can make the bactericidal effect of the bactericide better.

[0049] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present application rather than to limit the protection scope of the present application. Although the present application has been described in detail with reference to the preferred embodiments, those of ordinary skill in the art should understand that the technical solutions of the present application can be modified or equivalently replaced without departing from the essence and scope of the technical solutions of the present application.

Claims

1. A fungicide, characterized in that, It is composed of the following components by mass fraction: 3% - 10% lactic acid, 0.1% - 5% pH buffer, 0.01% - 2% chelating agent, 0.01% - 5% polyol humectant, 0.1% daily fragrance, 0.1% preservative, and the balance deionized water; the chelating agent includes at least one of hydroxyethylidene diphosphonic acid, tetrasodium glutamate diacetate, ethylenediaminetetraacetic acid, ethylenediaminetetraacetate, and octanoyl hydroxamic acid; the polyol humectant is at least one of glycerol, caprylyl glycol, butanediol, dipropylene glycol, and hexylene glycol; the pH buffer includes at least one of citric acid / sodium citrate, citric acid / potassium citrate, dihydrogen phosphate, and phosphoric acid / triethylammonium.

2. The fungicide according to claim 1, characterized in that, The mass fraction of the chelating agent in the bactericide is 0.05% - 1%.

3. The fungicide according to claim 1, characterized in that, The chelating agent includes hydroxyethylidene diphosphonic acid.

4. The fungicide according to claim 1, characterized in that, The mass fraction of the polyol humectant in the bactericide is 0.1% - 2%.

5. The fungicide according to claim 1, characterized in that, The mass fraction of lactic acid in the bactericide is 3% - 6%.

6. The fungicide according to claim 1, characterized in that, The mass fraction of the pH buffer in the bactericide is 0.5% - 2%.

7. The fungicide according to claim 1, wherein The pH buffer includes citric acid / sodium citrate.

8. A bactericidal wet wipe, characterized in that, It contains the bactericide according to any one of claims 1 - 7.

Images