Linear dynamic pressure filter control device and process for pharmaceutical intermediates

Abstract

The application discloses a linear dynamic pressure filter control device and process for a medical intermediate, and relates to the technical field of intermediate compound separation and solid-liquid separation. In the application, a flow divider is arranged at the opening position of the feed channel facing the filter cake tank. The rubber plate of the downstream flow divider is opposite to the multiple partition protrusions of the upstream flow divider. The multiple partition protrusions of the flow divider are in extrusion contact with the filter cloth and the rubber plate of the downstream flow divider. After the multiple partition protrusions of the flow divider extrude the filter cloth, multiple transverse flow dividing areas are formed at intervals. The inner wall of the vertical plate of the filter frame where the feed channel is located is provided with a first pressure sensitive resistor strip, and the inner wall of the other vertical plate of the filter frame is provided with a second pressure sensitive resistor strip. The application improves the pressure filtration performance of the filter cloth of the filter frame on the medical intermediate mixture, and reduces the pressure filtration energy consumption to a certain extent.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of intermediate compound separation and solid-liquid separation, and particularly relates to a linear dynamic filter pressing control device and process for pharmaceutical intermediates. BACKGROUND

[0002] During filter pressing of a pharmaceutical intermediate mixture, filter cake is formed in the filter frame of a plate-and-frame filter pressing structure, and filtered water in the mixture is discharged from a filter water pipeline. After the pharmaceutical intermediate mixture is injected into the filter frame and filter cloth of the filter structure, solid materials in the mixture gradually accumulate and form in the filter cake tank in the filter frame. During formation of the filter cake in the filter cake tank, due to the influence of distance and gravity of the pharmaceutical intermediate mixture during injection, local solid materials are prone to excessive settlement and aggregation. In order to form a relatively complete and qualified filter cake, a high injection pressure needs to be ensured. Excessive settlement and aggregation of local solid materials have a great impact on the filter cloth in this area. Excessive extrusion of the filter cloth in the current area not only causes a decrease in the current area "water passing" performance, but also has a "cut-off" effect on other filter areas. Therefore, improving the filter pressing and filtering performance of the filter frame filter cloth for the pharmaceutical intermediate mixture and reducing the filter pressing and filtering energy consumption have become a problem that needs to be paid attention to in the daily production and processing of pharmaceutical intermediates. SUMMARY

[0003] The present application solves the technical problem of providing a linear dynamic filter pressing control device and process for pharmaceutical intermediates, which not only improves the filter pressing and filtering performance of the filter frame filter cloth for the pharmaceutical intermediate mixture, but also reduces the filter pressing and filtering energy consumption to a certain extent.

[0004] To solve the above technical problems, the present application is implemented by the following technical scheme:

[0005] The application provides a linear dynamic pressure filtration control device for medical intermediates, which comprises a combined structure of multiple filter frames and filter cloths.

[0006] As a preferred technical scheme of the pressure filtration control device, the opening position of the feed channel towards the filter cake tank is provided with a lower clamping groove and an upper clamping groove.

[0007] As a preferred technical scheme of the pressure filtration control device, the transverse length of the upper clamping groove is greater than the transverse length of the upper clamping block, and the lower clamping block and the upper clamping block are both provided with a fixed mounting hole, and the lower clamping groove and the upper clamping groove are both provided with a threaded blind hole structure matched with the fixed mounting hole.

[0008] As a preferred technical scheme of the pressure filtration control device, the longitudinal sectional area of the feed channel is greater than the sum of the longitudinal sectional areas of the two filter water channels at the lower side of the filter frame.

[0009] As a preferred technical scheme of the pressure filtration control device, the first pressure-sensitive resistor strip and the second pressure-sensitive resistor strip are both provided with multiple uniformly distributed pressure-sensitive resistor blocks.

[0010] The application provides a linear dynamic pressure filtration control process for medical intermediates.

[0011] Link one, fluid constant-pressure injection and shunting: after the shunting body is installed at the position of the feed channel of the filter frame, the initial injection pressure preset by the control system is used to inject the medical intermediate mixture. The medical intermediate mixture is injected.

[0012] Link two, filter cake accumulation detection: after the medical intermediate mixture is independently separated by the multiple transverse separation zones of the shunt, the filter cake tank begins to accumulate the solidified filter cake in each area after being filtered by the filter cloth. The first and second pressure sensitive resistance strips sense and detect the filter cake extrusion degree at their respective positions.

[0013] Link three, injection pressure adjustment: the control system obtains the extrusion degree sensed and detected by the first and second pressure sensitive resistance strips. Let the extrusion degree sensed and detected by the first pressure sensitive resistance strip be , let the extrusion degree sensed and detected by the second pressure sensitive resistance strip be , and let the pressure difference be . If , the control system reduces the injection pressure of the medical intermediate mixture in the feed channel, let the injection pressure reduced by the control system be , then . If , the control system increases the injection pressure of the medical intermediate mixture in the feed channel, let the injection pressure increased by the control system be , then .

[0014] Link four, pressure filtration state trend monitoring: when the first and second pressure sensitive resistance strips on the inner walls of all filter frames simultaneously reach the maximum pressure value preset by the control system, the control stops continuing grouting.

[0015] Link five, time domain state monitoring: when the first and second pressure sensitive resistance strips on the inner walls of any one filter frame reach the maximum pressure value preset by the control system, after a certain period of time, among the remaining filter frames, the first and second pressure sensitive resistance strips on the inner walls of some filter frames still do not reach the maximum pressure value preset by the control system, then the filter frames whose first and second pressure sensitive resistance strips do not reach the maximum pressure value have a pressure filtration "jam" problem.

[0016] Compared with the existing technology, the beneficial effects of the present application are:

[0017] The present application designs a shunt structure in the plate and frame type pressure filtration structure, starts "guiding type" separation when injecting the mixture in the feed channel, changes the originally single direction of the mixture injection direction into multi-direction transverse separation, and sets the pressure sensitive resistance strips to sense and monitor the constantly changing pressure filtration forming state of the mixture, so as to facilitate the control system to efficiently and energy-savingly complete the pressure filtration injection control operation, which not only improves the pressure filtration and filtration performance of the filter cloth on the medical intermediate mixture, but also reduces the pressure filtration and filtration energy consumption to a certain extent (without the need to continuously maintain a high pressure state). BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 The combined structure diagram of the filter frame and filter cloth in the application.

[0019] Figure 2 The exploded structure diagram of the filter frame and filter cloth in the application.

[0020] Figure 3 The structure diagram of the filter frame in the application.

[0021] Figure 4 The structure diagram of the shunt in the application.

[0022] Figure 5 The structure diagram of the shunt in the application. Figure 4 The structure diagram of the shunt in the application.

[0023] Figure 6 The structure diagram of the shunt in the application. The structure diagram of the shunt in the application.

[0024] The structure diagram of the shunt in the application. Figure 7 The structure diagram of the shunt in the application. The structure diagram of the shunt in the application.

[0025] The structure diagram of the shunt in the application. Figure 8 The structure diagram of the shunt in the application. Figure 7 The structure diagram of the shunt in the application. The structure diagram of the shunt in the application.

[0026] The structure diagram of the shunt in the application. Figure 9 The structure diagram of the shunt in the application. The structure diagram of the shunt in the application.

[0027] The structure diagram of the shunt in the application. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical scheme and advantages of the application more clear, the application is further described in detail below in combination with the drawings and examples. It should be understood that the specific examples described herein are only used to explain the application, and are not used to limit the application.

[0029] Example 1

[0030] Please refer to Figure 1 , Figure 2, multiple filter frame 1, filter cloth 2 is spaced distribution installation, filter frame 1 and filter cloth 2 contact side can be provided with sealing ring, when filter frame 1 and filter cloth 2 extrusion, the pharmaceutical intermediates of the pulp will not penetrate to the outside of filter frame 1, filter frame 1 both sides of the position is also configured with guide bracket 101, facilitate all filter frame 1 synchronous hanging in the corresponding guide bracket, here can adopt the design structure of plate and frame filter press, to carry out the pharmaceutical intermediates mixture filter pressing.

[0031] Filter frame 1: a feed channel 102, a filter cake tank 104 and two filter water channel 105 are arranged, the feed channel 102 is located at one corner position on the upper side of the filter frame 1, and the two filter water channels 105 are located at two corner positions on the lower side of the filter frame 1. In addition, the longitudinal cross-sectional area of the feed channel 102 is greater than the sum of the longitudinal cross-sectional areas of the two filter water channels 105 on the lower side of the filter frame 1. The flow divider 106 is installed at the opening position of the feed channel 102 towards the filter cake tank 104.

[0032] Please refer to Figure 4 , Figure 5 , the flow divider 106 includes an outer inclined surface 1061, a plurality of partition protrusions 1062 and a rubber plate 1063 are arranged on the outer inclined surface 1061, the plurality of partition protrusions 1062 are located on one side of the outer inclined surface 1061, and the rubber plate 1063 is located on the other side of the outer inclined surface 1061. Among them, in the combined installation structure, the rubber plate 1063 of the downstream side flow divider 106 is opposite to the plurality of partition protrusions 1062 of the upstream side flow divider 106.

[0033] Please refer to Figure 1 , Figure 2 , Figure 5 , the plurality of partition protrusions 1062 of the flow divider 106 are directly extruded in contact with the filter cloth 2, the rubber plate 1063 of the downstream side flow divider 106 is also extruded, and the rubber plate 1063 of the downstream side flow divider 106 elastically buffers the extrusion contact force of the plurality of partition protrusions 1062 of the upstream side flow divider 106 on the filter cloth 2.

[0034] Please refer to Figure 2 , Figure 4 , Figure 6 , after the installation of the flow divider 106, the outer inclined surface 1061 faces the filter cake tank 104, and the upper end of the outer inclined surface 1061 extends into the filter cake tank 104, that is, the upper end of the outer inclined surface 1061 extends into the filter cake tank 104 longer than the lower end.

[0035] Please refer to Figure 5 , Figure 7 , Figure 8, the multiple partition protrusions 1062 of the shunt body 106 extrude the filter cloth 2 and form multiple transverse shunt areas 1067. The transverse size of the upper transverse shunt area 1067 is greater than that of the lower transverse shunt area 1067, and the longitudinal size of the upper transverse shunt area 1067 is greater than that of the lower transverse shunt area 1067, as shown in Figure 8 Fig. 3. The upper transverse shunt area 1067 extends farther and farther upward and the opening becomes larger and larger (for example, the longitudinal size of the bottom transverse shunt area 1067 is h1, and the longitudinal size of the second bottom transverse shunt area 1067 is h2, h2>h1. The farther the transverse shunt area 1067 is, the farther the maximum shunt distance is. The transverse shunt distance of the bottom transverse shunt area 1067 is L1, and the transverse shunt distance of the second bottom transverse shunt area 1067 is L2, L2>L1), so that the upper transverse shunt area 1067 shunts more and the fluid flows farther, reduces the "overlap" shunt area with the lower transverse shunt area 1067, and further improves the uniformity of the intermediate mixture shunt. In actual use, different shunt bodies 106 with different partition protrusion 1062 protrusion parameters need to be selected according to the thickness and elastic coefficient of the filter cloth 2 (combined with Figure 2 Fig. 3), which can not only ensure the transverse shunt effect, but also reduce the damage to the filter cloth 2 and ensure the long-term service life of the filter cloth 2.

[0036] Please refer to Figure 3 , Figure 6 , the opening position of the feed channel 102 towards the filter cake tank 104 is provided with a lower clamping groove 103a and an upper clamping groove 103b, and the shunt body 106 is provided with a lower clamping block 1064 and an upper clamping block 1065. The lower clamping block 1064 is located at the lower side of the shunt body 106, and the lower clamping block 1064 is installed at the position of the lower clamping groove 103a. The upper clamping block 1065 is located at the upper side of the shunt body 106, and the upper clamping block 1065 is installed at the position of the upper clamping groove 103b.

[0037] The transverse length of the upper clamping groove 103b is greater than the transverse length of the upper clamping block 1065. The lower clamping block 1064 and the upper clamping block 1065 are both provided with a fixed mounting hole 1066, and the positions of the lower clamping groove 103a and the upper clamping groove 103b are both provided with a threaded blind hole structure matched with the fixed mounting hole 1066. During installation, the upper clamping block 1065 needs to be installed first, the upper clamping block 1065 is clamped into the upper clamping groove 103b, then the lower clamping block 1064 is pushed transversely to be completely clamped into the lower clamping groove 103a, and then the bolt is installed in the fixed mounting hole 1066.

[0038] Please refer to Figure 1 , Figure 2 , Figure 3 , Figure 7The inner wall of the vertical plate where the feed channel 102 of the filter frame 1 is located is provided with a first varistor strip 107, and the inner wall of the other vertical plate of the filter frame 1 is provided with a second varistor strip 108.

[0039] Please see Figure 7 , Figure 9 Both the first varistor strip 107 and the second varistor strip 108 are equipped with multiple evenly distributed varistor blocks 109.

[0040] Example 2: This invention employs a linear dynamic pressure filtration control process for pharmaceutical intermediates, the main control process contents of which are as follows:

[0041] First, after installing the distributor 106 at the feed channel 102 of the filter frame 1, the initial injection pressure preset by the control system is then applied. The pharmaceutical intermediate mixture is injected into the feed channel 102. After being independently diverted by multiple horizontal diversion zones 1067 of the diversion channel 106, the pharmaceutical intermediate mixture is filtered by the filter cloth 2, and solidified filter cake begins to accumulate in each area of ​​the filter cake tank 104.

[0042] Then, the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108 sense and detect the filter cake compression force at their respective positions. The control system acquires the compression force detected by the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108. Let the compression force detected by the first pressure-sensitive resistor strip 107 be... Let the pressure force detected by the second pressure-sensitive resistor strip 108 be... Assume pressure difference .

[0043] Scenario 1: If The control system reduces the injection pressure of the pharmaceutical intermediate mixture in the feed channel 102 relative to the initial injection pressure. Let the injection pressure reduced by the control system be... ,but Here, when the pressure on the side of the first varistor strip 107 is less than the pressure on the second varistor strip 108, it indicates that after passing through the transverse diversion zone of the flow divider 106, most of the mixture moves and accumulates towards the direction of the second varistor strip 108. After the liquid in the mixture is discharged through the filter water channel, more solid material accumulates near the second varistor strip 108 and less solid material accumulates near the first varistor strip 107. This can reduce the injection pressure of the feed channel 102. After the mixture passes through the transverse diversion zone of the flow divider 106, the solid material accumulation rate near the first varistor strip 107 begins to catch up with or exceed the solid material accumulation rate near the second varistor strip 108, and the distribution of the solid material accumulation area gradually tends to be balanced.

[0044] Case two: if , the control system increases the injection pressure of the pharmaceutical intermediate mixture of the feed channel 102, relative to the initial injection pressure , assuming that the control system increases the injection pressure , then . Contrary to case one, here, when the pressure on the side of the first pressure-sensitive resistor strip 107 is greater than the pressure on the side of the second pressure-sensitive resistor strip 108, it indicates that, after passing through the lateral diversion area of the diversion body 106, most of the mixture moves and gathers towards the orientation of the first pressure-sensitive resistor strip 107, and after the liquid in the mixture is discharged through the filter water channel 105, the solid material remaining in the vicinity of the first pressure-sensitive resistor strip 107 gathers more, and the solid material remaining in the vicinity of the second pressure-sensitive resistor strip 108 gathers less. Therefore, the injection pressure of the feed channel 102 can be increased, and after the mixture passes through the lateral diversion area of the diversion body 106, the solid material gathering rate in the vicinity of the second pressure-sensitive resistor strip 108 starts to catch up with, or even exceed, the solid material gathering rate in the vicinity of the first pressure-sensitive resistor strip 107, and the solid material gathering area distribution gradually tends to be balanced.

[0045] Then, when the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108 on the inner wall of all filter frames 1 simultaneously reach the maximum pressure value preset by the control system , the control system stops continuing to inject slurry. In the analysis and calculation of the pressure values of the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108, the pressure values detected by all the pressure-sensitive resistor blocks of the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108 can be superimposed to determine the total pressure value borne by the entire pressure-sensitive resistor strip.

[0046] Finally, when the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108 on the inner wall of any filter frame 1 reach the maximum pressure value preset by the control system , after a certain period of time, in the remaining filter frames 1, the first pressure-sensitive resistor strip 107 and the second pressure-sensitive resistor strip 108 on the inner wall of the filter frame 1 still do not reach the maximum pressure value preset by the control system , then the filter frame 1 whose first pressure-sensitive resistor strip 107 and second pressure-sensitive resistor strip 108 do not reach the maximum pressure value has a pressure filtration “jamming” problem, and then the state of the filter cloth 2, the diversion body 106, etc. for pressure filtration in the filter frame 1 is checked after shutdown.

[0047] The above only describes the preferred embodiments of the present application and is not intended to limit the present application. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A linear dynamic pressure filtration control device for pharmaceutical intermediates, characterized in that: It includes a combination structure of multiple filter frames (1) and filter cloth (2); The filter frame (1) includes a feed channel (102), a filter cake trough (104), and two water filtration channels (105). The feed channel (102) is located at one corner of the upper side of the filter frame (1), and the water filtration channels (105) are located at one corner of the lower side of the filter frame (1). A flow divider (106) is installed at the opening of the feed channel (102) facing the filter cake trough (104). The flow divider (106) includes an outer inclined surface (1061), a plurality of partition protrusions (1062) located on one side of the outer inclined surface (1061), and a rubber plate (1063) located on the other side of the outer inclined surface (1061). The rubber plate (1063) of the downstream flow divider (106) is directly opposite the plurality of partition protrusions (1062) of the upstream flow divider (106). The plurality of partition protrusions (1062) of the flow divider (106) press against the filter cloth (2) and compress the rubber plate (1063) of the downstream flow divider (106). After the plurality of partition protrusions (1062) of the flow divider (106) compress the filter cloth (2), they form a plurality of horizontally placed flow divider zones (1067) at intervals. The outer inclined surface (1061) faces the filter cake trough (104), and the lateral length of the upper end of the outer inclined surface (1061) extending into the filter cake trough (104) is greater than the lateral length of its lower end extending into the filter cake trough (104). Among them, the lateral dimension of the horizontal diversion area (1067) at the upper position is greater than the lateral dimension of the horizontal diversion area (1067) at the lower position, and the longitudinal dimension of the horizontal diversion area (1067) at the upper position is greater than the longitudinal dimension of the horizontal diversion area (1067) at the lower position. The inner wall of the vertical plate where the feed channel (102) of the filter frame (1) is located is provided with a first varistor strip (107), and the inner wall of the other vertical plate of the filter frame (1) is provided with a second varistor strip (108).

2. The linear dynamic pressure filtration control device for pharmaceutical intermediates according to claim 1, characterized in that: The feed channel (102) is provided with a lower slot (103a) and an upper slot (103b) at the opening position facing the filter cake tank (104). The lower side of the distributor (106) is provided with a lower locking block (1064) installed at the lower locking slot (103a), and the upper side of the distributor (106) is provided with an upper locking block (1065) installed at the upper locking slot (103b).

3. The linear dynamic pressure filtration control device for pharmaceutical intermediates according to claim 2, characterized in that: The lateral length of the upper slot (103b) is greater than the lateral length of the upper slot block (1065). The lower slot block (1064) and the upper slot block (1065) are both provided with fixed mounting holes (1066). The lower slot (103a) and the upper slot (103b) are both provided with threaded blind hole structures that cooperate with the fixed mounting holes (1066).

4. The linear dynamic pressure filtration control device for pharmaceutical intermediates according to claim 1, characterized in that: The longitudinal cross-sectional area of ​​the feed channel (102) is greater than the sum of the longitudinal cross-sectional areas of the two water filtration channels (105) on the lower side of the filter frame (1).

5. The linear dynamic pressure filtration control device for pharmaceutical intermediates according to claim 1, characterized in that: Both the first varistor strip (107) and the second varistor strip (108) are equipped with multiple uniformly distributed varistor blocks (109).

6. A linear dynamic pressure filtration control process for pharmaceutical intermediates, characterized in that, The linear dynamic pressure filtration control device for pharmaceutical intermediates according to any one of claims 1 to 5 includes the following steps: Step 1: Fluid constant pressure injection and diversion After installing the distributor at the feed channel of the filter frame, inject it according to the initial injection pressure preset by the control system. Injecting a mixture of pharmaceutical intermediates; Step 2: Filter cake accumulation test After the pharmaceutical intermediate mixture is independently diverted through multiple horizontal diversion zones of the diversion fluid, and then filtered through the filter cloth, solidified filter cake begins to accumulate in each area of ​​the filter cake tank. The first and second piezoresistive strips sense and detect the pressure of the filter cake being squeezed at their respective positions; Step 3: Adjusting the injection pressure The control system acquires the squeezing force detected by the first and second pressure-sensitive resistor strips. Let the squeezing force detected by the first pressure-sensitive resistor strip be... Let the pressure force detected by the second pressure-sensitive resistor strip be... Assume pressure difference ; like The control system reduces the injection pressure of the pharmaceutical intermediate mixture in the feed channel. Let the reduction in injection pressure by the control system be... ,but ; like The control system increases the injection pressure of the pharmaceutical intermediate mixture in the feed channel. Let the increased injection pressure be... ,but ; Step 4: Monitoring the Filtration Pressure Trend When the first and second pressure-sensitive resistor strips on the inner walls of all filter frames simultaneously reach the maximum pressure value preset by the control system. If this occurs, then control and stop grouting; Step 5: Time-Domain Status Monitoring When the first and second pressure-sensitive resistor strips on the inner wall of any filter frame reach the maximum pressure value preset by the control system. At that time, after a certain period of time, the first and second pressure-sensitive resistor strips on the inner wall of the remaining filter frames still did not reach the maximum pressure value preset by the control system. If the first and second pressure-sensitive resistor strips do not reach the maximum pressure value, then... The filter frame has a problem of "clogging" during pressure filtration.

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