Blood purification equipment and storage media

Abstract

The present application discloses a blood purification device and a storage medium, the blood purification device comprising: a memory and a processor; the memory stores computer program instructions, the processor executes the computer program and implements the following method: controlling the blood pump to operate according to a detected user operation on the blood pump; controlling the citrate pump to output citrate solution when the speed of the blood pump is greater than a preset speed and the continuous operation time of the blood pump is greater than a first preset time; controlling the infusion pump to output replacement fluid when the total amount of citrate solution output by the anticoagulation branch is detected to be greater than a preset minimum total amount; adjusting the citrate flow rate output by the citrate pump according to the detected calcium ion concentration of the blood output by the intravenous pot and the blood flow rate of the intravenous line, and adjusting the replacement fluid flow rate output by the infusion pump according to the adjusted citrate flow rate. In this way, the safety of the patient's blood purification treatment can be ensured.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to a blood purification device and a storage medium. Background Art

[0002] During blood purification treatment, blood purification equipment uses anticoagulants such as citric acid to prevent the formation of blood clots and ensure that the patient's blood purification treatment process can continue to maintain a normal state. When using citric acid anticoagulation, related technologies inject citric acid into the arterial line through a citric acid pump, and simultaneously inject calcium solution into the venous line through another fluid infusion pump. The injection process of citric acid and calcium solution is independent of each other, and the flow rate of citric acid is also independent of the flow rate of blood in the line. This can cause hypercalcemia or hypocalcemia in the patient's blood, causing physical discomfort to the patient and even endangering the safety of the patient's blood purification treatment. Summary of the Invention

[0003] Based on this, the embodiments of the present application provide a blood purification device and a storage medium that can ensure the safety of blood purification treatment for patients.

[0004] In a first aspect, an embodiment of the present application provides a blood purification device, comprising: a memory and a processor; the memory is used to store computer program instructions, and the processor is used to execute the computer program and implement the following blood purification device control method when executing the computer program:

[0005] controlling the blood pump of the blood purification device to operate according to the detected user operation on the blood pump;

[0006] When the rotation speed of the blood pump is greater than a preset rotation speed and the continuous operation time of the blood pump is greater than a first preset time, controlling the citric acid pump of the blood purification device to output citric acid solution;

[0007] When it is detected that the total amount of citrate solution outputted by the anticoagulation branch of the blood purification device is greater than a preset minimum total amount, controlling the fluid infusion pump of the blood purification device to output replacement fluid;

[0008] The citric acid flow rate output by the citric acid pump is adjusted according to the detected calcium ion concentration of the blood output by the venous bottle of the blood purification equipment and the blood flow rate of the venous line of the blood purification equipment, and the replacement fluid flow rate output by the infusion pump is adjusted according to the adjusted citric acid flow rate.

[0009] In a second aspect, the present application provides a computer-readable storage medium storing a computer program, which, when executed by a processor, enables the processor to implement the control method of the blood purification device as described above.

[0010] The blood purification device of the embodiment of the present application can determine the blood flow of the arterial line according to the rotation speed of the blood pump. When the rotation speed of the blood pump is greater than the preset rotation speed and the continuous operation time of the blood pump is greater than the first preset time, the citrate pump outputs citrate solution, so that the blood flow of the arterial line is associated with the output of citrate; when the total amount of citrate solution output is greater than the preset minimum total amount, the infusion pump outputs replacement fluid, so that the total amount of citrate solution is associated with the output of the replacement fluid; the citrate flow is adjusted according to the calcium ion concentration of the blood output by the venous bottle and the blood flow of the venous line, and the replacement fluid flow is adjusted according to the adjusted citrate flow, so that the calcium ion concentration and the blood flow of the venous line are associated with the citrate flow, and the citrate flow is associated with the replacement fluid flow. Therefore, in this way, the coordination of the citrate flow, blood flow, and calcium solution flow can be ultimately achieved, a good blood anticoagulation effect can be achieved, and the blood in the line can maintain a normal and safe flow state, thereby ensuring the safety of the patient's blood purification treatment.

[0011] It should be understood that the foregoing general description and the following detailed description are exemplary and explanatory only and are not restrictive of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 This is a schematic diagram of the basic structure of an embodiment of the blood purification device of the present application;

[0013] Figure 2 This is a schematic diagram of the piping principle of an embodiment of the blood purification device of the present application;

[0014] Figure 3 This is a schematic diagram of the piping principle of an embodiment of the blood purification device of the present application in a dual plasma molecule adsorption treatment mode;

[0015] Figure 4 This is a flow chart of an embodiment of a control method for a blood purification device of the present application;

[0016] Figure 5 This is a schematic diagram of an embodiment of a curve showing the relationship between the rotational speed of a blood pump and the blood flow rate of an arterial line in a control method of a blood purification device of the present application;

[0017] Figure 6 This is a schematic diagram of an embodiment of a venous pot and its surrounding pipelines in the control method of the blood purification equipment of the present application.

[0018] Description of main components and symbols:

[0019] 1. Arterial line; 2. Venous line; 211. Blood inlet catheter; 222. Blood outlet catheter; 3. Anticoagulation branch; 4. Fluid infusion branch; 5. Blood pump; 6. Citrate pump; 7. Fluid infusion pump; 8. Blood purifier; 9. Venous canister; 10. Liquid level detector; 11. Heater; 12. Bubble detector; 13. Blood detector; 14. Doppler ultrasonic sensor; 15. Arterial clamp; 16. Venous clamp; 17. Plasma line; 18. Filtration pump; 19. Plasma separator; 20. Perfusion device; 21. Adsorption column; 22. Blood leakage detector; 23. Plasma canister; 24. Pressure regulating line; 25. Three-way valve; 26. Pressure sensor; 27. Vacuum pump. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are part of the embodiments of this application, not all of them. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0021] The flowcharts shown in the accompanying drawings are for illustrative purposes only and do not necessarily include all contents and operations / steps, nor must they be executed in the order described. For example, some operations / steps may be decomposed, combined, or partially merged, so the actual execution order may vary depending on the actual situation.

[0022] Blood purification equipment is a medical device that works by drawing the patient's blood out of the body and purifying it to remove certain pathogenic substances, thereby achieving the effect of purifying the blood and treating diseases. Figure 1 The basic structure of an embodiment of a blood purification device is shown. The blood purification device includes: a pump, a display screen, a clamp and other structures; the blood purification treatment process of the patient can be controlled by the blood purification device to ensure the safety of the patient's blood purification treatment.

[0023] Figure 2The pipeline principle of an embodiment of a blood purification device is shown. The pipeline of the blood purification device includes: a blood purification pipeline (including: an arterial pipeline 1, a venous pipeline 2, an anticoagulation branch 3, and a fluid infusion branch 4), a blood pump 5, a citric acid pump 6, a fluid infusion pump 7, a blood purifier 8, a venous pot 9, a liquid level detector 10, a heater 11, a bubble detector 12, a blood detector 13, an arterial clamp 15, a venous clamp 16 and other components; the arterial pipeline 1 outputs the human body's blood to the blood purifier 8, and after the blood is purified by the blood purifier 8, the venous pipeline 2 returns the purified blood to the patient's body to complete the blood purification process; when the blood is drawn out of the body, the contact between the blood and the pipeline can trigger the body's coagulation mechanism, thereby forming a thrombus to block the pipeline. Therefore, anticoagulants such as citric acid are needed during blood purification treatment to prevent the formation of thrombi, so as to ensure that the patient's blood purification treatment process can continue to maintain a normal state.

[0024] The principle of citric acid anticoagulant is: the coagulation process of blood requires the participation of free calcium. Citrate ions and calcium ions in the blood form a soluble complex, calcium citrate, which is difficult to dissociate. This complex is easily soluble in water and difficult to dissociate. The coagulation process is inhibited, thereby preventing blood coagulation. Citrate anticoagulant will cause a large loss of calcium ions in the blood, which can easily cause hypocalcemia in patients. Therefore, the use of citric acid anticoagulant requires the simultaneous supplementation of an appropriate amount of calcium ions to maintain the calcium ion balance in the patient's blood.

[0025] When the related technology uses citrate anticoagulation, citric acid is first injected into the arterial line through a citrate pump, and at the same time, calcium solution is injected into the venous line through another fluid infusion pump. The injection process of citric acid and the injection process of calcium solution are independent of each other, and the flow rate of citric acid is also independent of the flow rate of blood in the line. The flow rate of citric acid will not be dynamically adjusted as the flow rate of blood in the line changes. For example, if the flow rate of blood in the line decreases, there will be a risk of excessive citrate anticoagulation, and if the flow rate of blood in the line increases, there will be insufficient citrate anticoagulation. risk; the flow rate of calcium solution will not be dynamically adjusted with the change of citrate flow rate. For example, when injecting calcium solution into the intravenous line, if the flow rate of calcium solution is too low, there will be a risk of hypocalcemia in the blood. If the flow rate of calcium solution is too high, there will be a risk of hypercalcemia in the blood. When the patient's blood has hypercalcemia or hypocalcemia, the patient will feel unwell, and even endanger the safety of the patient's blood purification treatment. The citrate anticoagulation method in the related art cannot achieve the coordination of citrate flow, blood flow and calcium solution flow.

[0026] The blood purification device of the embodiment of the present application can determine the blood flow of the arterial line according to the rotation speed of the blood pump. When the rotation speed of the blood pump is greater than the preset rotation speed and the continuous operation time of the blood pump is greater than the first preset time, the citrate pump outputs citrate solution, so that the blood flow of the arterial line is associated with the output of citrate; when the total amount of citrate solution output is greater than the preset minimum total amount, the infusion pump outputs replacement fluid, so that the total amount of citrate solution is associated with the output of the replacement fluid; the citrate flow is adjusted according to the calcium ion concentration of the blood output by the venous bottle and the blood flow of the venous line, and the replacement fluid flow is adjusted according to the adjusted citrate flow, so that the calcium ion concentration and the blood flow of the venous line are associated with the citrate flow, and the citrate flow is associated with the replacement fluid flow. Therefore, in this way, the coordination of the citrate flow, blood flow, and calcium solution flow can be ultimately achieved, a good blood anticoagulation effect can be achieved, and the blood in the line can maintain a normal and safe flow state, thereby ensuring the safety of the patient's blood purification treatment.

[0027] The blood purification device and the control method of the blood purification device according to the embodiment of the present application are described in detail below with reference to the accompanying drawings.

[0028] See Figure 2 The blood purification equipment includes: a citric acid pump 6, a fluid infusion pump 7, a blood pump 5, a blood purifier 8, an anticoagulant branch 3, a fluid infusion branch 4, a venous pot 9, an arterial line 1 and a venous line 2; when the blood purifier 8 performs blood purification treatment on the patient's blood, the patient's blood is drawn out of the body, and the patient's blood is at risk of coagulation. The citric acid solution is output to the arterial line 1 through the anticoagulant branch 3, and the replacement fluid is output to the venous line 2 through the fluid infusion branch 4, so that the blood can maintain normal flow in the arterial line 1 and the venous line 2; the blood purification The device can realize various blood purification treatment modes. In each blood purification treatment mode, the type of blood purifier 8 will also be different; for example, in the blood perfusion treatment mode, the blood purifier includes: a blood perfusion device; in the hemodialysis treatment mode, the blood purifier includes: a hemodialyzer; etc. For some blood purification treatment modes, the blood purification pipeline also includes: a plasma pipeline, which is used to transmit plasma separated from the blood. A plasma pot is set in the plasma pipeline to remove bubbles in the plasma; taking the dual plasma molecule adsorption treatment mode as an example, Figure 3The diagram shows the principle of the pipeline in the dual plasma molecule adsorption treatment mode, wherein the pipeline includes: arterial pipeline 1, venous pipeline 2, anticoagulation branch 3, fluid infusion branch 4, blood pump 5, citrate pump 6, fluid infusion pump 7, blood purifier 8, venous pot 9, liquid level detector 10, heater 11, bubble detector 12, blood detector 13, arterial clamp 15, venous clamp 16, plasma pipeline 17, filtration pump 18, plasma separator 19, perfusion device 20, adsorption column 21, blood leakage detector 22, plasma pot 23; in the dual plasma molecule adsorption treatment mode, the blood purifier includes: plasma separator 19; and Figure 2 The difference is that Figure 3 The pipelines in the apparatus also include: a plasma pipeline 17, a plasma pot 23, a filtration pump 18, etc. After the plasma separator 19 separates the patient's blood, the plasma separator 19 will output the plasma to the plasma pipeline 17, and the plasma separator 19 will output the blood cells to the venous pipeline 2. The plasma will accumulate in the plasma pot 23 and can also remove bubbles in the plasma.

[0029] The present application discloses a blood purification device, such as Figure 2 As shown, the blood purification device includes: a citric acid pump 6, a fluid infusion pump 7, a blood pump 5, a blood purifier 8, an anticoagulation branch 3, a fluid infusion branch 4, a venous pot 9, an arterial line 1, and a venous line 2; the first end of the arterial line 1 is used to connect to the user's artery, the second end of the arterial line 1 is connected to the blood input end of the blood purifier 8, the first end of the venous line 2 is connected to the blood output end of the blood purifier 8, the second end of the venous line 2 is used to connect to the user's vein, the first end of the anticoagulation branch 3 is connected to the citric acid pump 6, the second end of the anticoagulation branch 3 is connected to the arterial line 1, the first end of the fluid infusion branch 4 is connected to the fluid infusion pump 7, the venous pot 9 is arranged on the venous line 2, the second end of the fluid infusion branch 4 is connected to the venous pot 9, and the blood pump 5 is arranged on the arterial line 1. See Figure 2 and Figure 3 In some embodiments, a Doppler ultrasonic sensor 14 provided on the anticoagulation branch 3 is used to detect the total amount of citrate solution outputted by the anticoagulation branch 3. In other embodiments, other flow rate detection sensors provided on the anticoagulation branch can also be used to detect the total amount of citrate solution outputted by the anticoagulation branch.

[0030] The blood purification device further includes: a memory and a processor; the memory is used to store computer program instructions, and the processor is used to execute the computer program and implement the following blood purification device control method when executing the computer program.

[0031] The processor may be a microcontroller unit, a central processing unit, a digital signal processor, etc. The memory may be a Flash chip, a read-only memory, a magnetic disk, an optical disk, a USB flash drive, or a mobile hard disk, etc.

[0032] See also Figure 4 , Figure 4 1 is a flow chart of an embodiment of a control method for a blood purification device of the present application, wherein the method comprises: step S101, step S102, step S103 and step S104.

[0033] Step S101: controlling the blood pump of the blood purification device to operate according to the detected user operation on the blood pump.

[0034] The user's operation on the blood pump indicates the user's blood purification treatment demand information. The user's operation on the blood pump can be implemented by: operating through a display screen, operating through an input device, and so on. After receiving the user's operation, the blood purification device can generate a first control instruction, and control the blood pump of the blood purification device to operate according to the first control instruction. The blood pump starts and provides a driving force to the arterial line so that the arterial line transports blood. The rotation speed of the blood pump affects the blood flow in the arterial line. When the rotation speed of the blood pump is greater, the driving force provided by the blood pump to the arterial line is greater, and the blood flow in the arterial line is greater; when the rotation speed of the blood pump is smaller, the driving force provided by the blood pump to the arterial line is smaller, and the blood flow in the arterial line is smaller; therefore, the blood flow in the arterial line can be controlled by the blood pump; wherein the rotation speed of the blood pump and the blood flow in the arterial line are directly proportional. For example, Figure 5 The graph shows the relationship between the rotation speed of the blood pump and the blood flow in the arterial line. This relationship curve can be summarized based on multiple clinical trials. When the rotation speed of the blood pump is changed, the blood flow in the arterial line will change accordingly.

[0035] Step S102: When the rotation speed of the blood pump is greater than a preset rotation speed and the continuous operation time of the blood pump is greater than a first preset time, controlling the citric acid pump of the blood purification device to output citric acid solution.

[0036] When the blood pump is started, its speed gradually increases. When the speed is less than or equal to the preset speed, it indicates that the blood pump is in the startup phase. When the speed is greater than the preset speed, it indicates that the blood pump is in the steady-state operation phase, and the patient is undergoing blood purification treatment. The preset speed is set to determine which phase the blood pump is in. For example, the preset speed can be 10 ml / min. Only when the blood pump is in the steady-state operation phase is citrate solution used to anticoagulate the blood in the arterial line. When the blood pump is in the startup phase, citrate solution is not needed to anticoagulate the blood in the arterial line, thereby avoiding the problem of premature delivery of citrate solution and the waste of citrate solution.

[0037] When blood is drawn out of the body, it must remain in contact with the inner wall of the tubing for a sufficient period of time for the blood in the tubing to initiate coagulation. If this contact time is too short, the blood in the tubing will not initiate coagulation. Therefore, the first preset duration in the present embodiment is used to determine whether the blood pump's operating time is too short. Only when the blood pump's continuous operation time exceeds the first preset duration is citric acid solution delivered to produce an anticoagulant effect on the blood in the tubing. For example, the first preset duration can be 5 minutes.

[0038] When the speed of the blood pump is greater than the preset speed and the continuous operation time of the blood pump is greater than the first preset time, the embodiment of the present application will output the citric acid solution to the arterial line to exert the citric acid anticoagulant effect of the blood purification equipment, and the control process of the citric acid pump has higher safety.

[0039] Step S103: When it is detected that the total amount of citrate solution outputted by the anticoagulation branch of the blood purification device is greater than a preset minimum total amount, the fluid infusion pump of the blood purification device is controlled to output replacement fluid.

[0040] The replacement fluid contains calcium ions and other ions that are beneficial to the human body. When the total amount of citrate output by the citrate pump through the anticoagulation branch is greater than the preset minimum total amount, it means that the blood in the pipeline has been connected to enough citrate solution, and it is necessary to control the infusion pump to output the replacement fluid to the intravenous pot through the infusion branch to replenish the calcium ions lost in the blood during the citrate anticoagulation process.

[0041] Only when the total amount of citrate solution connected to the pipeline reaches a specific volume will the citrate solution in the pipeline achieve a blood anticoagulant effect, and the citrate pump can continuously output the citrate solution to the arterial line. The preset minimum total amount in the embodiment of the present application is used to evaluate whether it is necessary to connect a replacement fluid to compensate for the lost calcium ions. When the total amount of citrate solution output by the citrate pump is less than or equal to the preset minimum total amount, the total amount of citrate solution output to the pipeline is too small and will not cause a significant loss of calcium ions in the blood, so there is no need to replenish the replacement fluid. When the total amount of citrate solution output by the citrate pump is greater than the preset minimum total amount, the total amount of citrate solution output to the pipeline will cause a large loss of calcium ions in the blood, increasing the probability of hypocalcemia in the patient. This requires the replacement fluid to be output to the venous line by the infusion pump to compensate for the calcium ions lost in the arterial line. The embodiment of the present application distinguishes whether it is necessary to use a replacement fluid for calcium supplementation by setting a preset minimum total amount to avoid ineffective calcium supplementation operations.

[0042] It should be noted that the preset minimum total amount is a pre-set value, for example, the preset minimum total amount is 3 ml, wherein the preset minimum total amount is related to the concentration of the citric acid solution. When the concentration of the citric acid solution is higher, the preset minimum total amount will be smaller. According to the concentration of the citric acid solution and after multiple experiments, the preset minimum total amount can be summarized.

[0043] In some embodiments, a Doppler ultrasonic sensor disposed on the anticoagulation branch is used to detect the total amount of citric acid solution output by the anticoagulation branch. The operating principle of the Doppler ultrasonic sensor is as follows: ultrasonic waves are transmitted to the citric acid solution in the pipeline. When the ultrasonic waves encounter obstacles, diffuse reflection occurs, and the Doppler effect reflects back the attenuated ultrasonic waves. The attenuated ultrasonic waves can be used to determine the citric acid flow rate in the anticoagulation branch. After the Doppler ultrasonic sensor continuously detects the citric acid flow rate in the anticoagulation branch for a period of time, the total amount of citric acid solution output by the anticoagulation branch can be determined.

[0044] Step S104: adjusting the citric acid flow rate output by the citric acid pump according to the detected calcium ion concentration of the blood output by the venous bottle of the blood purification device and the blood flow rate of the venous line of the blood purification device, and adjusting the replacement fluid flow rate output by the infusion pump according to the adjusted citric acid flow rate.

[0045] The intravenous pot is placed in the intravenous line and is used to remove bubbles from the blood in the intravenous line to prevent bubbles from forming in the blood returned to the patient. The blood output from the intravenous pot represents the blood returned to the patient, and the blood flow in the intravenous line represents the blood flow returned to the patient. Based on the calcium ion concentration of the blood output from the intravenous pot, it is possible to determine whether the calcium ion concentration of the blood returned to the patient is within a normal range. For example, the calcium ion concentration of the blood output from the intravenous pot and the blood flow in the intravenous line can be sampled every 1 second. The calcium ion concentration of the blood output from the intravenous pot can be detected using a detection method known in the relevant art, such as using a calcium concentration detection sensor to detect the calcium ion concentration in the blood. Another example is using a Doppler ultrasonic sensor to detect the blood flow in the intravenous line to sample and obtain the blood flow in the intravenous line.

[0046] According to the calcium ion concentration and the blood flow of the venous line, it is determined whether the citric acid flow output by the citric acid pump needs to be feedback-regulated. The adjusted citric acid flow can just meet the anticoagulant effect of the blood in the line, preventing the blood in the line from coagulating. After the citric acid flow is adjusted, the replacement fluid flow output by the infusion pump also needs to be adjusted. The adjusted replacement fluid flow and the adjusted citric acid flow can keep matching each other. The calcium ions supplemented by the replacement fluid can just make up for the calcium ions lost during the citric acid anticoagulation process, so as to avoid hypercalcemia or hypocalcemia in the patient during the citric acid anticoagulation process. Therefore, the embodiment of the present application performs adaptive and feedback regulation on the citric acid flow output by the citric acid pump. The replacement fluid flow output by the infusion pump changes with the change of the citric acid flow output by the citric acid pump. The blood flow of the venous line, the citric acid flow and the replacement fluid flow can be controlled in a linked manner to improve the adaptive control function of the patient's blood purification treatment process.

[0047] It should be noted that the citrate pump, fluid infusion pump and blood pump in the embodiments of the present application are all common electronic components. For example, the citrate pump, fluid infusion pump and blood pump can all be driven by motors, and the control methods of the three are equivalent to motor control methods. For example, by adjusting the speed of the motor and the speed of the blood pump, the driving force of the blood pump will change, and the blood flow in the arterial line will also change; for example, the speed of the motor is PWM (Pulse Width Modulation) adjusted, and the speed of the vacuum pump is PWM adjusted to change the air pressure in the venous bottle; for example, by controlling the power on or off of the motor, the blood pump can be controlled to run or stop; the specific control principles of the citrate pump, fluid infusion pump and blood pump are not described in detail here.

[0048] In some embodiments, step S104, adjusting the citric acid flow rate output by the citric acid pump according to the detected calcium ion concentration of the blood output by the venous bottle of the blood purification device and the blood flow rate of the venous line of the blood purification device, and adjusting the replacement fluid flow rate output by the infusion pump according to the adjusted citric acid flow rate, may include: sub-step S1041, sub-step S1042, sub-step S1043 and sub-step S1044.

[0049] Sub-step S1041: When it is detected that the calcium ion concentration is between a preset minimum safety concentration and a preset maximum safety concentration, a first flow adjustment ratio value is determined based on the blood flow in the venous line, and an adjusted citric acid flow rate is determined based on the first flow adjustment ratio value and the calcium ion concentration, wherein the adjusted citric acid flow rate is equal to the product of the first flow adjustment ratio value and the calcium ion concentration. That is, the adjusted citric acid flow rate = first flow adjustment ratio value * calcium ion concentration.

[0050] Sub-step S1042: Obtain a second flow adjustment ratio value.

[0051] Sub-step S1043: Determine an adjusted replacement fluid flow rate based on the second flow rate adjustment ratio and the adjusted citric acid flow rate, wherein the adjusted replacement fluid flow rate is equal to the product of the second flow rate adjustment ratio and the adjusted citric acid flow rate. That is, the adjusted replacement fluid flow rate = the second flow rate adjustment ratio * the adjusted citric acid flow rate.

[0052] Sub-step S1044: adjusting the citric acid flow rate output by the citric acid pump according to the adjusted citric acid flow rate, and adjusting the replacement fluid flow rate output by the infusion pump according to the adjusted replacement fluid flow rate.

[0053] The preset minimum safe concentration represents the lowest concentration limit of calcium ion concentration that the human body's blood can withstand. Once the calcium ion concentration is lower than the preset minimum safe concentration, the patient's blood is likely to develop hypocalcemia; the preset maximum safe concentration represents the highest concentration limit of calcium ion concentration that the human body's blood can withstand. Once the calcium ion concentration is higher than the preset maximum safe concentration, the patient's blood is likely to develop hypercalcemia; only when the calcium ion concentration is between the preset minimum safe concentration and the preset maximum safe concentration, the calcium ion concentration of the blood output by the intravenous bottle will be within a safe regulation range.

[0054] Exemplarily, both the preset minimum safety concentration and the preset maximum safety concentration may be standard physiological parameters of the human body, for example, the preset minimum safety concentration is 1.63 mmol / L, and the preset maximum safety concentration is 2.46 mmol / L.

[0055] When the calcium ion concentration of the blood output by the intravenous kettle is within a safe regulation range, the citric acid flow rate output by the citric acid pump can be feedback regulated. The citric acid flow rate output by the citric acid pump can be calculated based on the blood flow rate and the calcium ion concentration of the venous line. The blood flow rate of the venous line represents the amount of blood transported by the line. The first flow rate adjustment ratio value is determined based on the blood flow rate of the venous line. The first flow rate adjustment ratio value can be obtained based on multiple clinical trials. The first flow rate adjustment ratio value represents the proportional relationship between the citric acid flow rate and the calcium ion concentration. For example, Table 1 shows the corresponding relationship between the first flow rate adjustment ratio value and the blood flow rate of the venous line.

[0056] Table 1

[0057] Blood flow rate of the venous line (unit: ml / min) The first flow adjustment ratio value Less than 5 0.3 Greater than or equal to 5 and less than 6 0.25 Greater than or equal to 6 and less than 7 0.20 Greater than or equal to 7 and less than 8 0.15 Greater than or equal to 8 and less than 9 0.10 Greater than or equal to 9 and less than 10 0.05 Greater than or equal to 10 0.1

[0058] According to the corresponding relationship in Table 1 above, the first flow rate adjustment ratio value can be found according to the blood flow rate of the venous line. It should be noted that the corresponding relationship in Table 1 above is obtained after multiple clinical trials.

[0059] Once the first flow adjustment ratio is obtained, the citric acid flow rate output by the citric acid pump can be calculated. The calculated citric acid flow rate output by the citric acid pump is the adjusted citric acid flow rate output by the citric acid pump. For example, if the blood flow rate in the venous line is 7.5 ml / min, the first flow adjustment ratio value obtained according to Table 1 is 0.15. When the calcium ion concentration is detected to be 2.01 mmol / L, the citric acid flow rate output by the citric acid pump is calculated to be 0.15 * 2.01 = 0.3015 ml / h. This method ensures that the citric acid flow rate and blood flow rate are always matched, improving the anticoagulation control effect of the citric acid solution.

[0060] The second flow rate adjustment ratio value refers to the optimal ratio of the citric acid flow rate output by the citric acid pump to the replacement fluid flow rate output by the infusion pump. The second flow rate adjustment ratio value is related to the concentration of the citric acid solution and the replacement fluid concentration. Typically, the second flow rate adjustment ratio value can be determined based on previous clinical experience and pre-set. For example, if the concentration of the citric acid solution is 2.13mmol / L and the concentration of the replacement fluid is 1.83mmol / L, the second flow rate adjustment ratio value is 0.87. When the adjusted citric acid flow rate is 0.3015ml / h, the adjusted replacement fluid flow rate = 0.87 * 0.3015ml / h = 0.2623ml / h. The replacement fluid flow rate in the embodiment of the present application will change with the change of the citric acid flow rate. The adjusted replacement fluid flow rate and the adjusted citric acid flow rate can be kept completely matched. The replacement fluid output by the infusion pump can just make up for the calcium ions lost during the citric acid anticoagulation process, so as to prevent the problem of excessive or insufficient calcium supplementation during the citric acid anticoagulation process.

[0061] In an embodiment of the present application, the blood flow in the venous line, the citrate flow output by the citrate pump, and the replacement fluid flow output by the infusion pump can be controlled in a coordinated manner to improve the safety of the patient's blood purification treatment, and the blood in the pipeline of the blood purification equipment can always be in a safe flow state.

[0062] In some embodiments, the method may further include: step S105.

[0063] Step S105: When it is detected that the calcium ion concentration is lower than the preset minimum safety concentration, or the calcium ion concentration is higher than the preset maximum safety concentration, the blood pump is controlled to stop running and a first fault prompt signal is issued.

[0064] In the embodiment of the present application, when it is detected that the calcium ion concentration is lower than the preset minimum safety concentration, or the calcium ion concentration is greater than the preset maximum safety concentration, the blood pump stops operating and issues a first fault prompt signal to the user: the calcium ion concentration of the blood in the pipeline has a serious fault and the blood pump is in a stopped state. The user can promptly deal with the calcium ion concentration fault problem in the pipeline to prevent the blood purification equipment from being in a faulty operating state.

[0065] In some embodiments, in step S104, when the flow rate of citric acid output by the citric acid pump is adjusted according to the detected calcium ion concentration of the blood output by the venous bottle of the blood purification device and the blood flow rate of the venous line of the blood purification device, the method may further include: step S106 and step S107.

[0066] Step S106: When it is detected that the liquid level of the blood in the venous pot of the blood purification device is not within a safe liquid level range, the liquid level of the blood in the venous pot is adjusted and a second fault prompt signal is issued.

[0067] Step S107: When it is detected that the liquid level of the blood in the venous pot of the blood purification device is within a safe liquid level range, the air pressure in the venous pot is detected and displayed.

[0068] When the citrate flow rate in the anticoagulation branch is adjusted, the replacement fluid flow rate in the fluid infusion branch will also change, the blood flow rate in the arterial line will also change, and the blood flow rate output to the venous pot will also change. The blood level in the venous pot will change with the change in the blood flow rate in the venous line. At this time, it is necessary to determine whether the blood level in the venous pot is in a safe state, that is, whether the blood level in the venous pot is within the safe liquid level range.

[0069] The safe liquid level range may refer to a liquid level range in which the blood level in the venous bottle is within a safe range. Only when the blood level in the venous bottle is within the safe liquid level range can the blood in the venous line flow safely. If the blood level in the venous bottle is determined to be outside the safe liquid level range, it indicates that the blood level in the venous bottle is too high or too low, requiring adjustment of the blood level in the venous bottle. Thus, a liquid level adjustment operation is triggered to prevent the blood in the venous bottle from entering a faulty state. While the liquid level in the venous bottle is being adjusted, a second fault prompt signal is issued, which can both notify the user that the current blood level in the venous bottle is outside the safe liquid level range and that the blood level in the venous bottle is in an adjusted state.

[0070] When it is determined that the blood level in the intravenous bottle is within a safe liquid level range, there is no need to adjust the blood level in the intravenous bottle. In order to further confirm that the air pressure in the intravenous bottle is maintained in a stable state, the air pressure in the intravenous bottle can be detected and displayed. The user can identify the safe state of the intravenous bottle based on the displayed air pressure in the intravenous bottle.

[0071] It should be noted that in the embodiments of the present application, the "liquid level of blood in the venous bottle" may refer to the height of the blood stored in the venous bottle. In some embodiments, the liquid level of blood in the venous bottle may be expressed as a ratio. For example, if the liquid level of blood in the venous bottle is 1 / 3 of the height of the venous bottle, this means that the ratio between the actual liquid level of blood in the venous bottle and the theoretical maximum liquid level of the blood in the venous bottle is 1 / 3.

[0072] In some embodiments, see Figure 6 A pressure regulating line 24 is provided on the intravenous pot 9. One end of the pressure regulating line 24 is provided at the inlet of the intravenous pot 9. The other end of the pressure regulating line 24 is connected to a pressure sensor 26 and a vacuum pump 27 via a three-way valve 25. During blood purification treatment, the intravenous line is used to transport purified blood. Blood can be accumulated in the intravenous pot and then returned to the patient's veins by the intravenous line to complete the patient's blood purification treatment.

[0073] At this time, in step S106, the adjusting the liquid level of the blood in the venous pot may include: energizing the vacuum pump, controlling the three-way valve to connect the pressure regulating pipeline and the vacuum pump, and adjusting the speed of the vacuum pump to adjust the liquid level of the blood in the venous pot.

[0074] At this time, in step S107 , detecting the air pressure in the venous pot may include: controlling the three-way valve to connect the pressure regulating pipeline and the pressure sensor, and detecting the air pressure in the venous pot through the pressure sensor.

[0075] In an embodiment of the present application, the conduction state of the pressure regulating pipeline can be switched through the three-way valve to meet the liquid level adjustment requirements of the blood in the venous kettle and the air pressure detection requirements in the venous kettle, thereby improving the control safety of the liquid level of the blood in the venous kettle and preventing the venous pipeline from being in a blood flow failure state.

[0076] In some embodiments, please refer to Figure 2 and Figure 6 The venous line 2 includes a blood input conduit 211 and a blood output conduit 222. One end of the blood input conduit 211 is connected to the blood output end of the blood purifier 8, and the other end of the blood input conduit 211 is connected to the inlet of the venous pot 9. One end of the blood output conduit 222 is connected to the outlet of the venous pot 9, and the other end of the blood output conduit 222 is used to connect to the user's vein. During the patient's blood purification treatment, the blood input conduit 211 outputs blood to the venous pot 9, and the blood output conduit 222 outputs the blood in the venous pot 9 to the user's vein.

[0077] The safe liquid level range may be between a preset minimum safe liquid level and a preset maximum safe liquid level (inclusive of both), wherein the preset minimum safe liquid level and the preset maximum safe liquid level are both preset values. For example, the preset minimum safe liquid level is 1 / 3 of the height of the intravenous pot, and the preset maximum safe liquid level is 2 / 3 of the height of the intravenous pot; then the safe liquid level range is: [1 / 3 of the height of the intravenous pot, 2 / 3 of the height of the intravenous pot].

[0078] At this time, in step S106, the vacuum pump is powered on, the three-way valve is controlled to connect the pressure regulating pipeline and the vacuum pump, and the speed of the vacuum pump is adjusted to adjust the liquid level of the blood in the venous bottle, which may include: sub-step S106A1 and sub-step S106A2.

[0079] Sub-step S106A1: When it is detected that the blood level in the venous bottle is lower than the preset minimum safety level, the vacuum pump is controlled to connect the pressure regulating pipeline to the outside atmosphere, the blood output conduit of the venous pipeline is controlled to be clamped off, and the speed of the vacuum pump is controlled to be 0.

[0080] Sub-step S106A2: When it is detected that the blood level in the venous bottle is greater than the preset maximum safety level, the vacuum pump is controlled to operate, and the speed of the vacuum pump is pulse-width modulated (PWM) to output gas into the venous bottle.

[0081] Specifically, when the liquid level of the blood in the venous pot is lower than the preset minimum safety liquid level, it means that the liquid level of the blood in the venous pot is too low, which will cause the blood stored in the venous pot to be mixed with bubbles, and the blood in the blood output catheter is likely to be mixed with bubbles. When the liquid level of the blood in the venous pot is higher than the preset maximum safety liquid level, it means that the liquid level of the blood in the venous pot is too high, and the venous pot is likely to rupture, resulting in the risk of infection of the blood in the venous pot. Therefore, when it is detected that the liquid level of the blood in the venous pot is lower than the preset minimum safety liquid level, the vacuum pump is controlled to connect the pressure regulating pipeline to the outside atmosphere, and the blood output catheter is clamped off. The blood output catheter cannot transmit blood, and the blood is continuously output to the venous pot through the blood input catheter. The gas in the venous pot is discharged to the outside of the venous pot through the pressure regulating pipeline. The blood in the venous pot will continue to accumulate, and the liquid level of the blood in the venous pot will rise. After the rise, the liquid level of the blood in the venous pot will be within the safe liquid level range. This method of increasing the liquid level of the blood in the venous pot depends entirely on the blood input. The catheter outputs blood to the venous pot to raise the blood level, without the need to adjust the blood level in the venous pot by adjusting the speed of the vacuum pump. This prevents the blood level in the venous pot from rising too quickly or suddenly during the adjustment process. For example, if the speed of the vacuum pump is used to control the blood level in the venous pot, there is usually a relatively high positive pressure in the venous pot. If the speed of the vacuum pump is slightly changed, the blood level in the venous pot will rise quickly and suddenly, and may even rush blood into the pressure regulating line, making the blood level in the venous pot very difficult to adjust. The blood level raising method in the embodiment of the present application is more convenient and has higher control safety.

[0082] When it is detected that the blood level in the venous bottle is greater than the preset maximum safe level, the vacuum pump is controlled to operate, and the venous bottle is inflated by the vacuum pump. The air pressure in the venous bottle rises, and the blood level in the venous bottle will drop. The rate of drop of the blood level in the venous bottle is directly proportional to the speed of the vacuum pump. After the drop, the blood level in the venous bottle will be within the safe liquid level range.

[0083] PWM regulation modulates the width of a series of vacuum pump pulses to equivalently obtain the desired waveform, thereby changing the vacuum pump's speed. When the vacuum pump's speed changes, the rate at which the vacuum pump inflates the intravenous bottle varies, and the rate at which the blood level in the intravenous bottle changes also varies. Therefore, in the embodiment of the present application, by implementing PWM regulation on the vacuum pump's speed, the blood level in the intravenous bottle can be returned to a safe level range after adjustment, significantly ensuring the safety of the blood level in the intravenous bottle.

[0084] In an embodiment of the present application, the speed of the vacuum pump is set to 0, and the blood output tube is clamped off so that the liquid level of the blood in the venous pot can be adjusted upward; the speed of the vacuum pump is PWM-adjusted so that the liquid level of the blood in the venous pot can be adjusted downward; this method brings great convenience to the liquid level adjustment of the blood in the venous pot.

[0085] In some embodiments, in sub-step S106A2, when PWM adjustment is performed on the rotation speed of the vacuum pump, it can also include: when it is detected that the liquid level change rate of the blood in the venous bottle is not within the normal rate range, feedback control is performed on the rotation speed of the vacuum pump so that the liquid level change rate of the blood in the venous bottle after feedback control is restored to the normal rate range.

[0086] Specifically, when the speed of the vacuum pump is PWM-regulated, the rate of change of the liquid level of the blood in the venous bottle is detected to determine whether the rate of change of the liquid level of the blood in the venous bottle is abnormal, wherein the normal rate range can represent: the normal numerical range of the rate of change of the liquid level of the blood in the venous bottle. When the rate of change of the liquid level of the blood in the venous bottle is not within the normal rate range, it indicates that the rate of change of the liquid level of the blood in the venous bottle is too high or too low. Therefore, when the speed of the vacuum pump is PWM-regulated, when the rate of change of the liquid level of the blood in the venous bottle is detected to be abnormal, the speed of the vacuum pump is feedback-controlled. After the feedback control, the speed of the vacuum pump will be maintained in a stable state. Correspondingly, the rate of change of the liquid level of the blood in the venous bottle will also return to the normal rate range after the feedback control, thereby ensuring the safety of the change of the liquid level of the blood in the venous bottle.

[0087] It should be noted that the feedback control method for the rotation speed of the vacuum pump may adopt a feedback control method in related technologies, such as a PID (Proportional Integral Derivative) feedback control method.

[0088] In some embodiments, in step S107, after controlling the three-way valve to connect the pressure regulating line and the pressure sensor and detecting the air pressure in the venous pot by the pressure sensor, the method may further include: step S108 and step S109.

[0089] Step S108: determining the preset maximum safety pressure corresponding to the current blood level in the venous pot according to the one-to-one correspondence between the blood level in the venous pot, the preset liquid level gear in the venous pot, and the preset safety pressure value.

[0090] Step S109: When it is detected that the air pressure in the venous pot is greater than the current preset maximum safety air pressure, the blood input catheter of the venous line is controlled to be clamped off, the fault state of the venous pot is detected, and a third fault prompt signal is issued.

[0091] Specifically, the level of blood in the intravenous pot affects the air pressure safety within the pot. There is a one-to-one correspondence between the preset intravenous pot liquid level levels and the preset safety air pressure values. Each preset intravenous pot liquid level level corresponds to a preset intravenous pot blood level range. Based on the intravenous pot blood level, the preset intravenous pot liquid level level corresponding to the blood level in the pot can be determined, and thus the corresponding preset safety air pressure value can be determined. For example, Table 2 shows the correspondence between the preset intravenous pot liquid level levels and the preset safety air pressure values.

[0092] Table 2

[0093]

[0094] As shown in Table 2, when the liquid level in the intravenous pot is detected to be less than 1 / 3 of the pot's height, the third level is determined to correspond to the preset safety pressure value of 100 mmHg. When the liquid level in the intravenous pot is detected to be greater than or equal to 1 / 3 of the pot's height but less than 2 / 3 of the pot's height, the second level is determined to correspond to the preset safety pressure value of 89 mmHg. When the liquid level in the intravenous pot is detected to be greater than or equal to 2 / 3 of the pot's height, the first level is determined to correspond to the preset safety pressure value of 73 mmHg. When the liquid level in the intravenous pot is detected, the corresponding preset safety pressure value can be found according to the corresponding relationship in Table 2. The corresponding preset safety pressure value is used as the preset maximum safety pressure. If the air pressure in the intravenous pot is detected to be greater than the current preset maximum safety pressure, it indicates that the air pressure in the intravenous pot is too high. Therefore, the embodiment of the present application establishes a correlation between the liquid level of the blood in the venous bottle and the air pressure in the venous bottle, so as to more accurately and comprehensively determine whether the blood in the venous bottle is in a fault state.

[0095] For example, when the blood level in the intravenous pot is detected to be 3 / 5 of the height of the intravenous pot, in the above Table 2, the 3 / 5 height of the intravenous pot is in the second gear, and the preset safety air pressure value is 89 mmHg; at the 3 / 5 height of the intravenous pot, if the air pressure in the intravenous pot is detected to be greater than 89 mmHg, the blood inlet catheter is clamped off, and the fault status of the intravenous pot is detected to analyze the specific cause of the fault of the intravenous pot.

[0096] It should be noted that the relevant data in Table 2 above are obtained through summarization of multiple clinical experiences, and the specific sources of the relevant data in Table 2 are not elaborated in detail here.

[0097] In the embodiment of the present application, when it is determined that the blood level in the intravenous bottle is normal (i.e., within the safe liquid level range), it is necessary to determine whether there is a fault in the air pressure in the intravenous bottle. When it is detected that the air pressure in the intravenous bottle is greater than the current preset maximum safe pressure, it indicates that the air pressure in the intravenous bottle is too high and the blood inlet catheter needs to be clamped off. The inlet of the intravenous bottle is no longer connected to blood. The intravenous bottle fault state needs to be immediately detected to understand the specific cause of the intravenous bottle fault (e.g., the outlet of the intravenous bottle is blocked, causing the air pressure in the intravenous bottle to rise sharply, and then the air pressure in the intravenous bottle exceeds the current preset maximum safe pressure, etc.). At the same time, a third fault prompt signal (e.g., an audible and visual alarm signal) is issued to notify the user that there is a pressure fault in the intravenous bottle, so that the user can promptly correct the fault state of the intravenous bottle and ensure the safety of blood storage in the intravenous bottle. It should be noted that the fault state of the intravenous bottle can be detected using a fault detection method in the related art, which will not be described in detail here.

[0098] The embodiment of the present application dually judges whether the venous pot has an abnormality by using the liquid level of the blood in the venous pot and the air pressure in the venous pot, thereby preventing the problem of abnormality judgment error caused by unilaterally judging whether the venous pot has an abnormality based on only the liquid level of the blood in the venous pot or only the air pressure in the venous pot.

[0099] In some embodiments, in sub-step S106A1, when it is detected that the liquid level of the blood in the venous bottle is lower than the preset minimum safety liquid level, before controlling the vacuum pump to connect the pressure regulating pipeline to the external atmosphere, it may also include: step S110.

[0100] Step S110: When it is detected that the blood flow rate in the blood input conduit of the venous line is less than a first preset flow rate, the blood flow rate in the blood input conduit is increased so that the increased blood flow rate in the blood input conduit is greater than or equal to the first preset flow rate; and when it is detected that the blood flow rate in the blood input conduit of the venous line is greater than or equal to a second preset flow rate, the blood flow rate in the blood input conduit is reduced so that the reduced blood flow rate in the blood input conduit is less than the second preset flow rate. The first preset flow rate is less than the second preset flow rate.

[0101] Specifically, when it is detected that the blood level in the venous pot is less than a preset minimum safe level, before adjusting the blood level in the venous pot upward, the blood flow rate in the blood inlet conduit can be detected. If the blood flow rate in the blood inlet conduit is too high (i.e., the blood flow rate in the blood inlet conduit is greater than or equal to a second preset flow rate), the rate at which the venous pot receives blood will be too fast, which will cause the blood level in the venous pot to rise at a very high rate, making it extremely inconvenient to control the increase in the blood level in the venous pot. Therefore, before connecting the pressure regulating line to the outside atmosphere, the embodiment of the present application reduces the blood flow rate in the blood inlet conduit in advance to prevent the blood from being received too quickly. This allows the blood level in the venous pot to rise more easily, and allows the blood level in the venous pot to slowly rise to a safe level range. After the reduced blood flow rate in the blood inlet conduit is less than the second preset flow rate, the vacuum pump is controlled to connect the pressure regulating line to the outside atmosphere.

[0102] Specifically, when it is detected that the blood flow rate in the blood inlet conduit is too low (i.e., the blood flow rate in the blood inlet conduit is less than a first preset flow rate), although this situation can control the blood level in the venous pot to rise safely, the blood flow rate in the blood inlet conduit is too low, and the rate of increase of the blood level in the venous pot is too slow. In this case, it is necessary to increase the blood flow rate in the blood inlet conduit to greater than or equal to the first preset flow rate. The blood inlet conduit outputs blood to the venous pot at a rate greater than or equal to the first preset flow rate, so that the blood level in the venous pot can be efficiently raised and the raised blood level in the venous pot can quickly reach a safe liquid level range. After the increased blood flow rate in the blood inlet conduit is greater than or equal to the first preset flow rate, the vacuum pump is controlled to connect the pressure regulating line to the outside atmosphere.

[0103] That is to say, when the blood flow in the blood inlet catheter is greater than or equal to the first preset flow rate and less than the second preset flow rate, it means that the blood flow in the blood inlet catheter is in a normal state, the blood inlet catheter will output the blood to the venous pot according to the normal blood flow rate, and the blood level in the venous pot will rise steadily.

[0104] Exemplarily, the first preset flow rate may be 30 ml / min, and the second preset flow rate may be 150 ml / min. When the blood flow rate in the blood inlet catheter is detected to be greater than or equal to 30 ml / min and less than 150 ml / min, it indicates that under the current blood flow conditions, the blood level in the venous bottle can be directly and safely increased.

[0105] It should be noted that "30ml / min" is used to determine whether the blood flow in the blood inlet catheter is too low, and "150ml / min" is used to determine whether the blood flow in the blood inlet catheter is too high. 30ml / min and 150ml / min can be derived based on multiple clinical experiences. The specific sources and specific principles of 30ml / min and 150ml / min are not explained in detail here.

[0106] In some embodiments, in step S106, the vacuum pump is powered on, the three-way valve is controlled to connect the pressure regulating pipeline and the vacuum pump, and the speed of the vacuum pump is adjusted to adjust the liquid level of the blood in the venous bottle. The method also includes: step S111, step S112 and step S113.

[0107] Step S111: Record and display the continuous power-on time of the vacuum pump.

[0108] Step S112: When the continuous power-on time of the vacuum pump is greater than the second preset time and less than the third preset time, and when it is detected that the liquid level of the adjusted blood in the venous bottle is not within the safe liquid level range, an emergency prompt signal is issued.

[0109] Step S113: When the continuous power-on time of the vacuum pump is greater than or equal to the third preset time, and when it is detected that the liquid level of the blood in the adjusted venous bottle is not within the safe liquid level range, the blood inlet catheter is controlled to be clamped off, the vacuum pump is controlled to lose power, and a fourth fault prompt signal is issued.

[0110] The third preset duration is greater than the second preset duration.

[0111] Specifically, the continuous power-on time of the vacuum pump represents the continuous change time of the liquid level of the blood in the venous kettle. According to the continuous power-on time of the vacuum pump, it can be judged whether the continuous adjustment time of the liquid level of the blood in the venous kettle is within the normal time range; in the most standard liquid level adjustment state, the liquid level of the blood in the venous kettle can be adjusted to the safe liquid level range within the second preset time, and the liquid level of the blood in the venous kettle is in a normal adjustment state; when the continuous adjustment time of the liquid level of the blood in the venous kettle is greater than the second preset time and less than the third preset time, it means that the continuous adjustment time of the liquid level of the blood in the venous kettle is too long, but the liquid level of the blood in the venous kettle can be adjusted to the safe liquid level range within the third preset time, and the liquid level of the blood in the venous kettle is still within the allowable adjustment time range; but when the venous kettle When the continuous adjustment time of the liquid level of the blood in the venous kettle is greater than or equal to the third preset time, the liquid level of the blood in the venous kettle after adjustment still does not return to the safe liquid level range, which means that the liquid level adjustment process of the blood in the venous kettle is in a fault state. In this case, it is necessary to clamp the blood input catheter, control the vacuum pump to lose power, and stop the liquid level adjustment process of the blood in the venous kettle. It is necessary to promptly investigate the cause of the fault state in the liquid level adjustment process of the blood in the venous kettle; therefore, the embodiment of the present application divides the warning time of the continuous power-on time of the vacuum pump into the second preset time and the third preset time, so as to adopt different feedback reminder methods for the liquid level adjustment process of the blood in the venous kettle, thereby ensuring the continuity of the patient's blood purification treatment and timely ensuring the safety of the liquid level adjustment of the blood in the venous kettle.

[0112] Exemplarily, the third preset time is: 15S, and the second preset time is: 10S; only when the continuous power-on time of the vacuum pump is less than or equal to 10S, it means that the liquid level of the blood in the venous bottle is adjusted to the safe liquid level range within the standard time; when the continuous power-on time of the vacuum pump is greater than 10S and less than 15S, and the adjusted liquid level of the blood in the venous bottle is not within the safe liquid level range, a yellow light source can be emitted (the yellow light source here is an emergency prompt signal), but as long as the liquid level of the blood in the venous bottle returns to the safe liquid level range within a time range of less than 15S, it is still within the allowable adjustment time range. The yellow light source may not be emitted at this time; when the continuous power-on time of the vacuum pump is greater than or equal to 15S, and the adjusted blood level in the venous kettle is not within the safe liquid level range, a red light source may be emitted (the red light source here is the fourth fault prompt signal). The continuous adjustment time of the blood level in the venous kettle is obviously too long, and a fault has occurred. It is necessary to clamp off the blood input catheter and control the vacuum pump to lose power. The blood level in the venous kettle no longer changes, and the fault status of the venous kettle is detected until the fault of the venous kettle is eliminated. Then, the blood input catheter is reopened and the vacuum pump is controlled to be powered on to continue to adjust the blood level in the venous kettle.

[0113] In some embodiments, in step S106 , when the liquid level of the blood in the venous bottle is adjusted, the method may further include: step S114 and step S115 .

[0114] Step S114: When it is detected that the blood flow in the blood input conduit of the venous line is not within the normal flow fluctuation range, a fifth fault prompt signal is issued.

[0115] Step S115: When it is detected that the blood flow in the blood input conduit is within a normal flow fluctuation range, and the absolute value of the difference between the blood flow of the blood input conduit and the blood flow of the blood output conduit of the venous line is greater than or equal to a preset flow difference, the blood input conduit and the blood output conduit are controlled to be clamped off, and a sixth fault prompt signal is issued.

[0116] Specifically, the normal flow fluctuation range represents the safe variation range of the blood flow in the blood inlet catheter. When the speed of the vacuum pump is adjusted, the liquid level of the blood in the venous pot will change, which will also cause the blood flow in the blood inlet catheter to change. For example, the blood flow in the blood inlet catheter will rise or fall. When the blood flow in the blood inlet catheter after the rise or fall is not within the normal flow fluctuation range, it means that the blood flow in the blood inlet catheter after the rise or fall is too high or too low. By issuing a fifth fault prompt signal (such as an audible or visual signal), a prompt can be given to the user: there is a fault in the blood flow in the blood inlet catheter. Upon receiving the fifth fault prompt signal, the user will immediately deal with the blood flow fault in the blood inlet catheter, thereby greatly ensuring the safety of the blood flow in the blood inlet catheter during the liquid level adjustment process of the venous pot.

[0117] It should be noted that the normal flow rate fluctuation range can be summarized based on previous clinical experience; for example, the normal flow rate fluctuation range is: 5ml / min to 20ml / min. It should also be noted that in step S110, the blood flow rate in the blood inlet catheter is reduced, and the blood flow rate in the blood inlet catheter after the reduction is still within the normal flow rate fluctuation range of the embodiment of the present application.

[0118] Furthermore, when it is determined that the blood flow in the blood inlet conduit is within a normal flow fluctuation range, a preset flow difference represents an allowable flow error range between the blood inlet conduit and the blood outlet conduit. The preset flow difference can be summarized in advance based on clinical experience, for example, the preset flow difference is 1 ml / min. When the absolute value of the difference between the blood flow in the blood inlet conduit and the blood flow in the blood outlet conduit is less than 1 ml / min, it indicates that the blood in the venous pot is in a normal storage state, there are no cracks on the side wall of the venous pot, and the venous pot has not experienced a leakage fault. When the absolute value of the difference between the blood flow in the blood inlet conduit and the blood flow in the blood outlet conduit is greater than or equal to 1 ml / min, it indicates that the blood stored in the venous pot is in a fault state, there are cracks on the side wall of the venous pot, and the blood in the venous pot has leaked to the outside through the cracks, resulting in a leakage fault. The blood inlet conduit and the blood outlet conduit are both clamped off, and a sixth fault prompt signal is issued.

[0119] In an embodiment of the present application, when the blood level in the venous kettle is within a safe liquid level range, the flow rate difference between the blood input catheter and the blood output catheter is used to determine whether the venous kettle has a leakage fault, thereby facilitating the user to repair and handle the leakage fault of the venous kettle.

[0120] In some embodiments, see Figure 6 The intravenous pot 9 is also equipped with an infrared temperature sensor 28 and a heater 11. The infrared temperature sensor 28 operates by utilizing infrared light radiated by an object to enter the infrared temperature sensor, where it is absorbed by the thermopile and converted into an electrical signal, thereby achieving its temperature measurement function. The infrared temperature sensor 28 can detect the temperature of the blood within the intravenous pot 9, while the heater 11 can heat the blood within the intravenous pot 9. When the arterial and venous lines draw the patient's blood out of the body, the blood within these lines will experience a drop in temperature. The heater can adaptively heat the blood within the intravenous pot, ensuring that the blood discharged from the blood delivery catheter is maintained at a temperature suitable for the human body, ensuring the safety of the patient undergoing blood purification treatment.

[0121] The method may further include: step S116, step S117 and step S118.

[0122] Step S116: using the infrared temperature sensor to detect the temperature of the blood in the intravenous bottle.

[0123] Step S117: controlling the heater to heat the blood in the venous bottle.

[0124] Step S118: Feedback adjustment is performed on the heating temperature of the heater according to the temperature of the blood in the venous bottle detected by the infrared temperature sensor.

[0125] The embodiment of the present application performs feedback adjustment on the heating temperature of the heater based on the temperature measurement results of the infrared temperature sensor, so that the blood in the intravenous bottle heated by the heater can be safely returned to the patient's body; for example, when the infrared temperature sensor detects that the temperature of the blood in the intravenous bottle is too low, the heating temperature of the heater is increased; when the infrared temperature sensor detects that the temperature of the blood in the intravenous bottle is too high, the heating temperature of the heater is lowered; the method of performing feedback adjustment on the heating temperature of the heater in the embodiment of the present application can maintain the heating safety of the heater.

[0126] Illustratively, in step S118, the heating temperature of the heater is feedback-adjusted according to the temperature of the blood in the venous bottle, wherein the method for feedback-adjusting the heating temperature of the heater may adopt the feedback-adjustment method in the related art, such as the PID feedback-adjustment method; therefore, the embodiment of the present application can ensure the temperature safety of the blood in the venous bottle by feedback-adjusting the heating temperature of the heater, and the heating process of the heater has higher control simplicity.

[0127] This application also provides a computer-readable storage medium storing a computer program. When executed by a processor, the computer program causes the processor to implement any of the above-described control methods for blood purification devices. For detailed descriptions of the relevant content, please refer to the relevant content of the above-described control methods for blood purification devices, which will not be repeated here.

[0128] The computer-readable storage medium may be an internal storage unit of the blood purification device, such as a hard disk or memory. The computer-readable storage medium may also be an external storage device, such as a plug-in hard disk, smart memory card, secure digital card, flash memory card, etc.

[0129] It should be understood that the terms used in the specification of the present application are only used to describe specific embodiments and are not intended to limit the present application.

[0130] It will also be understood that the term "and / or" used in this specification and the appended claims refers to and includes any and all possible combinations of one or more of the associated listed items.

[0131] The above descriptions are merely specific embodiments of the present application, but the scope of protection of the present application is not limited thereto. Any person skilled in the art can easily conceive of various equivalent modifications or substitutions within the technical scope disclosed in the present application, and such modifications or substitutions should be included within the scope of protection of the present application. Therefore, the scope of protection of the present application should be based on the scope of protection of the claims.

Claims

1. A blood purification device, characterized in that: The blood purification device includes: a memory and a processor; the memory is used to store computer program instructions, and the processor is used to execute the computer program and implement the following blood purification device control method when executing the computer program: controlling the blood pump of the blood purification device to operate according to the detected user operation on the blood pump; When the rotation speed of the blood pump is greater than a preset rotation speed and the continuous operation time of the blood pump is greater than a first preset time, controlling the citric acid pump of the blood purification device to output citric acid solution; When it is detected that the total amount of citrate solution outputted by the anticoagulation branch of the blood purification device is greater than a preset minimum total amount, controlling the fluid infusion pump of the blood purification device to output replacement fluid; The citric acid flow rate output by the citric acid pump is adjusted according to the detected calcium ion concentration of the blood output by the venous bottle of the blood purification equipment and the blood flow rate of the venous line of the blood purification equipment, and the replacement fluid flow rate output by the infusion pump is adjusted according to the adjusted citric acid flow rate.

2. The blood purification device according to claim 1, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: When it is detected that the calcium ion concentration is between a preset minimum safety concentration and a preset maximum safety concentration, determining a first flow adjustment ratio value according to the blood flow in the venous line, and determining an adjusted citric acid flow rate according to the first flow adjustment ratio value and the calcium ion concentration, wherein the adjusted citric acid flow rate is equal to the product of the first flow adjustment ratio value and the calcium ion concentration; Obtaining a second flow adjustment ratio value; determining an adjusted replacement fluid flow rate according to the second flow adjustment ratio value and the adjusted citric acid flow rate, wherein the adjusted replacement fluid flow rate is equal to the product of the second flow adjustment ratio value and the adjusted citric acid flow rate; adjusting the citric acid flow rate output by the citric acid pump according to the adjusted citric acid flow rate, and adjusting the replacement fluid flow rate output by the infusion pump according to the adjusted replacement fluid flow rate; When it is detected that the calcium ion concentration is lower than the preset minimum safety concentration, or the calcium ion concentration is higher than the preset maximum safety concentration, the blood pump is controlled to stop running and a first fault prompt signal is issued.

3. The blood purification device according to claim 1, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: When it is detected that the liquid level of the blood in the venous pot of the blood purification device is not within a safe liquid level range, the liquid level of the blood in the venous pot is adjusted and a second fault prompt signal is issued; When it is detected that the liquid level of the blood in the venous pot of the blood purification device is within a safe liquid level range, the air pressure in the venous pot is detected and displayed.

4. The blood purification device according to claim 3, characterized in that: A pressure regulating pipeline is provided on the intravenous pot, one end of the pressure regulating pipeline is provided at the inlet of the intravenous pot, and the other end of the pressure regulating pipeline is connected to a pressure sensor and a vacuum pump through a three-way valve; The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: The vacuum pump is powered, the three-way valve is controlled to connect the pressure regulating pipeline and the vacuum pump, and the speed of the vacuum pump is adjusted to adjust the liquid level of the blood in the venous bottle; The three-way valve is controlled to connect the pressure regulating pipeline and the pressure sensor, and the air pressure in the intravenous bottle is detected by the pressure sensor.

5. The blood purification device according to claim 4, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: When it is detected that the blood level in the venous bottle is lower than a preset minimum safety level, the vacuum pump is controlled to connect the pressure regulating pipeline to the outside atmosphere, the blood output conduit of the venous pipeline is controlled to be clamped off, and the speed of the vacuum pump is controlled to be 0; When it is detected that the blood level in the venous pot is greater than the preset maximum safety level, the vacuum pump is controlled to operate, and the speed of the vacuum pump is pulse-width modulated (PWM) to output gas into the venous pot.

6. The blood purification device according to claim 5, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: When it is detected that the blood flow in the blood input conduit of the venous line is less than a first preset flow, the blood flow in the blood input conduit is increased so that the increased blood flow in the blood input conduit is greater than or equal to the first preset flow; When it is detected that the blood flow in the blood input conduit of the venous line is greater than or equal to a second preset flow, the blood flow in the blood input conduit is reduced so that the reduced blood flow in the blood input conduit is less than the second preset flow.

7. The blood purification device according to claim 4, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: Determining the preset maximum safety air pressure corresponding to the current blood level in the venous pot according to a one-to-one correspondence between the blood level in the venous pot, the preset liquid level gear in the venous pot, and the preset safety air pressure value; When it is detected that the air pressure in the venous pot is greater than the current preset maximum safety air pressure, the blood input catheter of the venous line is controlled to be clamped off, the fault state of the venous pot is detected, and a third fault prompt signal is issued.

8. The blood purification device according to claim 4, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: Recording and displaying the continuous power-on time of the vacuum pump; When the continuous power-on time of the vacuum pump is longer than the second preset time and shorter than the third preset time, and it is detected that the liquid level of the blood in the regulated venous bottle is not within the safe liquid level range, an emergency prompt signal is issued; When the continuous power-on time of the vacuum pump is greater than or equal to the third preset time, and it is detected that the liquid level of the blood in the adjusted venous bottle is not within the safe liquid level range, the blood inlet catheter is controlled to be clamped off, the vacuum pump is controlled to lose power, and a fourth fault prompt signal is issued.

9. The blood purification device according to claim 3, characterized in that: The processor is configured to execute the computer program and implement the following blood purification device control method when executing the computer program: When it is detected that the blood flow in the blood input conduit of the venous line is not within a normal flow fluctuation range, a fifth fault prompt signal is issued; When it is detected that the blood flow in the blood input conduit is within a normal flow fluctuation range, and the absolute value of the difference between the blood flow of the blood input conduit and the blood flow of the blood output conduit of the venous line is greater than or equal to a preset flow difference, the blood input conduit and the blood output conduit are controlled to be clamped off, and a sixth fault prompt signal is issued.

10. A computer-readable storage medium, characterized in that The computer-readable storage medium stores a computer program, and when the computer program is executed by a processor, the processor implements the control method of the blood purification device according to any one of claims 1 to 9.

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