Hydration solution for color blindness and weak color vision correction lenses and hydration method for color blindness and weak color vision correction lenses

Abstract

The application provides a kind of corrects color blindness weak lens hydrating liquid and the hydration method of correcting color blindness weak lens, belongs to the technical field of correcting color blindness weak lens preparation.The corrects color blindness weak lens hydrating liquid provided by the application includes organic solvent, anionic surfactant and water, the volume ratio of the organic solvent and water is (3-7) :(3-7), the mass fraction of the anionic surfactant is 0.5-5%, the correcting color blindness weak lens is hydrogel lens, and the dye used is cationic dye.Using the hydrating liquid provided by the application can quickly precipitate the unreacted dye residues in the correcting color blindness weak lens.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of color blindness and weak color vision correction lens preparation, and particularly relates to a color blindness and weak color vision correction lens hydration solution and a color blindness and weak color vision correction lens hydration method. BACKGROUND

[0002] Color blindness refers to color vision disorder caused by abnormal or incomplete photopigment in cone cells, so as to lack the ability to distinguish one or several colors, and poor color discrimination is called color weakness. Congenital color blindness is mostly a genetic disease, and there is currently no cure, but it can be corrected by increasing the color perception of color blindness patients. The commonly used method to increase the color perception of color blindness patients is to wear color blindness correction glasses, and the current contact lenses with color blindness correction function are a research hotspot.

[0003] Rhodamine is often used in color blindness and weak color vision correction optical devices, such as patent CN113248466A, which uses rhodamine dye with a double bond to mix with a contact lens raw material monomer mixture to prepare a dry sheet by cross-linking copolymerization, and then washes and hydrates the dry sheet with water, physiological saline or buffer physiological saline to remove dye residues that have not been polymerized with the contact lens raw material monomer mixture, thereby obtaining a color blindness correction contact lens. However, contact lenses need to be stored in an aqueous solution for a long time, and using the washing and hydration method in the above patent, the color blindness correction contact lens prepared finally still has the problem of slow dye precipitation when stored in an aqueous solution. Therefore, it is of great significance to provide a hydration method that can quickly precipitate dyes in color blindness correction contact lenses, thereby providing stable color blindness correction contact lenses. SUMMARY

[0004] The present application aims to provide a color blindness and weak color vision correction lens hydration solution and a color blindness and weak color vision correction lens hydration method, which can quickly precipitate unreacted dye residues in color blindness and weak color vision correction lenses using the hydration solution provided by the present application.

[0005] In order to achieve the above-mentioned application purposes, the present application provides the following technical solutions:

[0006] The present application provides a color blindness and weak color vision correction lens hydration solution, which comprises an organic solvent, an anionic surfactant and water, the volume ratio of the organic solvent to water is (3-7):(3-7), and the mass fraction of the anionic surfactant is 0.5-5%; the color blindness and weak color vision correction lens is a hydrogel lens, and the dye used is a cationic dye.

[0007] Preferably, the organic solvent comprises one or more of alcohol, dimethyl sulfoxide, N,N-dimethylformamide, acetone and acetonitrile.

[0008] Preferably, the alcohol includes one or more of ethanol, propanol, propylene glycol, and glycerol.

[0009] Preferably, the anionic surfactant includes citrate or anionic polyacrylamide.

[0010] Preferably, the cationic dye is a cationic dye with a methacrylate or acrylate group.

[0011] Preferably, the cationic dye has a structure shown in Formula I:

[0012]

[0013] In Formula I, R is A is a substituent containing at least one unsaturated double bond.

[0014] Preferably, A is an olefin group, an olefin derivative group, or a group having a structure shown in Formula II:

[0015]

[0016] In Formula II, R1 is -H or an alkyl group, and n is an integer from 0 to 20.

[0017] The olefin derivative group contains at least one of a carbonyl group, an alkoxy group, an amide group, an aromatic group, and a heterocyclic ring.

[0018] Preferably, the colorblindness and color weakness correction lens is a colorblindness and color weakness correction contact lens.

[0019] The present application provides a hydration method of a colorblindness and color weakness correction lens, comprising the following steps:

[0020] Mixing the colorblindness and color weakness correction lens with a hydration liquid for hydration treatment; the hydration liquid is the colorblindness and color weakness correction lens hydration liquid in the above technical solution.

[0021] Preferably, the temperature of the hydration treatment is 20-100℃, and the time is 0.5-8h.

[0022] Preferably, the hydration liquid is replaced every 0.5-2h during the hydration treatment.

[0023] The application provides a kind of corrects color blindness weak lens hydrating liquid, including organic solvent, anionic surfactant and water, the volume ratio of the organic solvent and water is (3-7) :(3-7), the mass fraction of the anionic surfactant is 0.5-5%;The correction color blindness weak lens is hydrogel lens and the dye used is cationic dye.The hydrating liquid provided by the application can improve the swelling rate of hydrogel lens, increase the space structure of hydrogel lens material interlinked structure, and the mutual attraction between anionic surfactant and cationic dye, so that the unreacted cationic dye can be quickly precipitated in hydrating liquid, and it will not have adverse effects on the lens, greatly shorten the hydrating treatment time, thereby facilitating to reduce the breakage rate of lens in processing, and improve production efficiency;In addition, it is beneficial to reduce the replacement frequency of hydrating liquid, reduce the use amount of hydrating liquid and hydrating cost. BRIEF DESCRIPTION OF DRAWINGS

[0024] Figure 1 It is the hydrating treatment effect diagram under different time conditions in example 1;

[0025] Figure 2 It is the hydrating treatment effect diagram under different time conditions in example 2;

[0026] Figure 3 It is the hydrating treatment effect diagram under different time conditions in example 3;

[0027] Figure 4 It is the hydrating treatment effect diagram under different time conditions in example 4;

[0028] Figure 5 It is the hydrating treatment effect diagram under different time conditions in example 5;

[0029] Figure 6 It is the hydrating treatment effect diagram under different time conditions in example 6;

[0030] Figure 7 It is the hydrating treatment effect diagram under different time conditions in example 7;

[0031] Figure 8 It is the hydrating treatment effect diagram under different time conditions in example 8;

[0032] Figure 9 It is the hydrating treatment effect diagram under different time conditions in comparative example 1;

[0033] Figure 10 It is the hydrating treatment effect diagram under different time conditions in comparative example 2;

[0034] Figure 11 It is the hydrating treatment effect diagram under different time conditions in comparative example 3;

[0035] Figure 12 Figure 4 shows the effect of hydration treatment at different time conditions in Comparative Example 4. DETAILED DESCRIPTION

[0036] The present application provides a corrective color blindness and weakness lens hydration solution, which comprises an organic solvent, an anionic surfactant and water, the volume ratio of the organic solvent to water is (3-7):(3-7), the mass fraction of the anionic surfactant is 0.5-5%, the corrective color blindness and weakness lens is a hydrogel lens and the dye used is a cationic dye.

[0037] The corrective color blindness and weakness lens hydration solution provided by the present application comprises an organic solvent, which preferably comprises one or more of alcohol, dimethyl sulfoxide, N,N-dimethylformamide, acetone and acetonitrile, and more preferably alcohol, dimethyl sulfoxide, N,N-dimethylformamide, acetone or acetonitrile; the alcohol preferably comprises one or more of ethanol, propanol, propylene glycol and glycerol, and more preferably ethanol, propanol, propylene glycol or glycerol.

[0038] The corrective color blindness and weakness lens hydration solution provided by the present application comprises an anionic surfactant, which preferably comprises a citrate or an anionic polyacrylamide; the citrate preferably comprises sodium citrate and / or potassium citrate.

[0039] The corrective color blindness and weakness lens hydration solution provided by the present application comprises water.

[0040] In the present application, the volume ratio of the organic solvent to water in the corrective color blindness and weakness lens hydration solution is preferably (3-7):(3-7), and can be specifically 3:7, 4:6, 5:5, 6:4 or 7:3; the mass fraction of the anionic surfactant in the hydration solution is 0.5-5%, preferably 1-4.5%, further preferably 1.5-4%, more preferably 2-3.5%, and still more preferably 2.5-3%. In the present application, too much anionic surfactant is not easy to dissolve, and too little anionic surfactant is not conducive to improving the hydration effect.

[0041] The corrective color blindness and weakness lens hydration solution provided by the present application is suitable for a corrective color blindness and weakness lens which is a hydrogel lens and the dye used is a cationic dye. In the present application, the hydrogel lens is defined as a contact lens made of a water-absorbing material (which has an equilibrium water content greater than or equal to 10% in a standard salt solution at 20°C), which can be a silicon hydrogel lens or a fluorosilicon hydrogel lens, and the present application does not have special limitations.

[0042] In the present application, the cationic dye preferably has the structure shown in Formula I:

[0043]

[0044] R in formula I is A is a substituent containing at least one unsaturated double bond.

[0045] In the present application, the A is preferably an olefin group, an olefin derivative group, or a group having a structure shown in formula II:

[0046]

[0047] R1 in formula II is -H or an alkyl group, and n is an integer from 0 to 20.

[0048] The olefin derivative group contains at least one of a carbonyl group, an alkoxy group, an amido group, an aromatic group, and a heterocyclic ring.

[0049] In the present application, the cationic dye can be specifically dye I, dye II, or dye III; the structure of the dye I is specifically shown as follows:

[0050]

[0051] The structure of the dye II is specifically shown as follows:

[0052]

[0053] The structure of the dye III is specifically shown as follows:

[0054]

[0055] In the present application, the colorblindness and color weakness correcting lens is preferably a colorblindness and color weakness correcting contact lens. In the present application, the method for preparing the colorblindness and color weakness correcting lens preferably comprises the following step: mixing lens raw material monomers with dyes for crosslinking copolymerization to obtain the colorblindness and color weakness correcting lens. The present application does not have special limitations on the type of lens raw material monomers, and any lens raw material monomers known to those skilled in the art for preparing hydrogel lenses can be used, such as one or more of hydroxyethyl methacrylate (HEMA), glycidyl methacrylate, glyceryl methacrylate, hydroxybutyl methacrylate, hydroxypropyl methacrylate, methacrylic acid, methyl methacrylate, ethyl methacrylate, propyl methacrylate, butyl methacrylate, isobornyl methacrylate, N-vinylpyrrolidone (NVP), N,N-dimethylacrylamide, N-methyl-N-vinylacetamide, 3-(3-methacryloyloxy-2-hydroxypropyl)propyl bis(trimethylsiloxy)methylsilane, 3-acrylamidopropyl tris(trimethylsiloxy)silane, monomethacrylamidopropyl-terminated mononormal-butyl-terminated polydimethylsiloxane, methacryloyloxypropyl tris(trimethylsiloxy)silane, monomethacryloyloxypropyl-terminated mononormal-butyl-terminated polydimethylsiloxane, and fluorinated siloxane methacrylate, preferably hydroxyethyl methacrylate and N-vinylpyrrolidone. When the lens raw material monomers are hydroxyethyl methacrylate and N-vinylpyrrolidone, the mass ratio of the hydroxyethyl methacrylate to the N-vinylpyrrolidone is preferably (4.5-5.0):0.3, more preferably 4.7:0.3.

[0056] In the present application, the cross-linking copolymerization is preferably carried out in the presence of a polymerization initiator and a cross-linking agent; the mass of the polymerization initiator is preferably 0.1-0.8% of the mass of the lens raw material monomers, and further preferably 0.3-0.5%; the mass of the cross-linking agent is preferably 0.1-2% of the mass of the lens raw material monomers, and further preferably 0.5-1.5%. In the present application, the polymerization initiator preferably includes a thermal initiator or a photoinitiator; the thermal initiator preferably includes azobisisobutyronitrile (AIBN) or benzoyl peroxide (BPO); and the photoinitiator preferably includes 2-hydroxy-2-methylpropyl phenone (D1173). In the present application, the cross-linking agent preferably includes ethylene glycol dimethacrylate (EGDMA) or polyethylene glycol diacrylate (PEGDA). In the present application, the cross-linking copolymerization is preferably carried out by thermal polymerization curing or photopolymerization curing. In the present application, when thermal polymerization curing is used, the polymerization initiator is preferably a thermal initiator; the temperature of the thermal polymerization curing is preferably 60-130°C, and more preferably 100-120°C; and the time is preferably 8-30h, and more preferably 8-15h. In the present application, the photopolymerization curing is preferably carried out under the irradiation of an ultraviolet lamp with a wavelength of 275-398nm and an intensity of 4-30mW / cm 2 , and the time of the photopolymerization curing is preferably 0.5-4h.

[0057] After the cross-linking copolymerization, the obtained color-blindness-correcting lens contains unreacted dye, and the use of the hydrating solution provided by the present application for hydrating treatment can quickly and completely remove the unreacted dye; especially for color-blindness-correcting contact lenses, which need to be stored in an aqueous solution for a long time, the use of the hydrating solution provided by the present application can quickly and completely remove the unreacted dye, thereby avoiding the problem of slow dye precipitation when the lens is stored in an aqueous solution.

[0058] The present application provides a hydrating method for a color-blindness-correcting lens, comprising the following steps:

[0059] Mixing the color-blindness-correcting lens with a hydrating solution for hydrating treatment; the hydrating solution is the color-blindness-correcting lens hydrating solution described in the above technical solution.

[0060] In the present application, the temperature of the hydration treatment is preferably 20-100℃, more preferably 25-80℃, and further preferably 40-60℃; the time is preferably 0.5-8h, and more preferably 3-4h. In the present application, the hydration liquid is replaced every 0.5-2h, and more preferably every 1h, during the hydration treatment. In the present application, the colorblindness-correcting lens is exemplified by a colorblindness-correcting contact lens, and specifically, one piece of colorblindness-correcting contact lens is placed in the hydration liquid for the hydration treatment, and the amount of the hydration liquid is preferably 3-7mL, and more preferably 5mL; in actual production, the number of colorblindness-correcting lenses and the volume of the hydration liquid can be adjusted according to actual conditions; in the examples of the present application, one piece of colorblindness-correcting contact lens is placed in 5mL of hydration liquid for the hydration treatment, and the hydration liquid is replaced every 1h during the hydration treatment.

[0061] In the examples of the present application, after the colorblindness-correcting lens is subjected to the hydration treatment with the hydration liquid for colorblindness-correcting lens provided by the present application, the obtained lens is preferably placed in pure water for hydration for 1.5-2.5h (further preferably 2h) and then placed in standard saline for storage.

[0062] The technical solutions in the present application will be clearly and completely described below in combination with the examples in the present application. Obviously, the described examples are only some of the examples of the present application, but not all the examples. Based on the examples in the present application, all other examples obtained by those skilled in the art without creative work fall within the protection scope of the present application.

[0063] The preparation method of the colorblindness-correcting contact lens used in the following examples and comparative examples of the present application comprises the following steps:

[0064] The lens raw material monomer hydroxyethyl methacrylate (HEMA) 4.7g and N-vinyl pyrrolidone (NVP) 0.3g are weighed, 1.5% of the total mass of the lens raw material monomer of crosslinking agent ethylene glycol dimethacrylate (EGDMA), 0.5% of the total mass of the lens raw material monomer of initiator azobisisobutyronitrile (AIBN), and 0.3% of the total mass of the lens raw material monomer of dye I are added, mixed and stirred for 1h, then added to the lens mold, and cured in a 120℃ oven for 8h. The mold is opened to obtain the colorblindness-correcting contact lens (contact lens dry sheet).

[0065] Example 1

[0066] Ethanol and water are mixed, and sodium citrate is added to the obtained ethanol aqueous solution, and stirred at room temperature (25℃) for 3h to obtain a hydration liquid; the volume ratio of ethanol to water in the hydration liquid is 50:50, and the mass fraction of sodium citrate is 2%.

[0067] The colorblindness and weak color vision correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at room temperature for 4 h. The hydration solution is replaced every hour during the hydration process. The hydrated colorblindness and weak color vision correcting contact lenses are placed in pure water for 2 h and then stored in standard saline.

[0068] Figure 1 The hydration treatment effect diagram under different time conditions in Example 1 is shown in FIG. 1. Figure 1 As shown in FIG. 1, the colorblindness and weak color vision correcting contact lenses are hydrated in the hydration solution in Example 1 for 4 h, and the residual colorblindness dye that is not polymerized with the lens raw material can be completely analyzed out.

[0069] Example 2

[0070] Propylene glycol and water are mixed, and potassium citrate is added to the obtained propylene glycol aqueous solution. The mixture is stirred at room temperature for 5 h to obtain a hydration solution. The volume ratio of propylene glycol to water in the hydration solution is 40:60, and the mass fraction of sodium citrate is 2.5%.

[0071] The colorblindness and weak color vision correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at room temperature for 4 h. The hydration solution is replaced every hour during the hydration process. The hydrated colorblindness and weak color vision correcting contact lenses are placed in pure water for 2 h and then stored in standard saline.

[0072] Figure 2 The hydration treatment effect diagram under different time conditions in Example 2 is shown in FIG. 2. Figure 2 As shown in FIG. 2, the colorblindness and weak color vision correcting contact lenses are hydrated in the hydration solution in Example 2 for 4 h, and the residual colorblindness dye that is not polymerized with the lens raw material can be completely analyzed out.

[0073] Example 3

[0074] Propyl alcohol and water are mixed, and anionic polyacrylamide is added to the obtained propyl alcohol aqueous solution. The mixture is stirred at room temperature for 3 h to obtain a hydration solution. The volume ratio of propyl alcohol to water in the hydration solution is 70:30, and the mass fraction of anionic polyacrylamide is 2%.

[0075] The colorblindness and weak color vision correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at room temperature for 4 h. The hydration solution is replaced every hour during the hydration process. The hydrated colorblindness and weak color vision correcting contact lenses are placed in pure water for 2 h and then stored in standard saline.

[0076] Figure 3 The hydration treatment effect diagram under different time conditions in Example 3 is shown in FIG. 3. Figure 3It can be seen that the residual colorblind dye which is not polymerized with the lens raw material can be analyzed out by using the hydration liquid in Example 3 to hydrate the colorblind and weak color vision correcting contact lenses for 4h.

[0077] Example 4

[0078] The glycerol is mixed with water, and sodium citrate is added to the obtained glycerol aqueous solution, and stirred at room temperature for 3h to obtain a hydration liquid; the volume ratio of propylene glycol to water in the hydration liquid is 30:70, and the mass fraction of sodium citrate is 5%;

[0079] The colorblind and weak color vision correcting contact lenses are placed in 5mL of the hydration liquid, and hydrated at room temperature for 3h, and the hydration liquid is replaced every hour during the hydration process, and the hydrated colorblind and weak color vision correcting contact lenses are placed in pure water for hydration for 2h and then stored in standard saline.

[0080] Figure 4 The hydration treatment effect diagram under different time conditions in Example 4 is shown in Figure 4 It can be seen that the residual colorblind dye which is not polymerized with the lens raw material can be analyzed out by using the hydration liquid in Example 4 to hydrate the colorblind and weak color vision correcting contact lenses for 3h.

[0081] Example 5

[0082] The dimethyl sulfoxide is mixed with water, and anionic polyacrylamide is added to the obtained dimethyl sulfoxide aqueous solution, and stirred at 40℃ for 3h to obtain a hydration liquid; the volume ratio of dimethyl sulfoxide to water in the hydration liquid is 50:50, and the mass fraction of anionic polyacrylamide is 2%;

[0083] The colorblind and weak color vision correcting contact lenses are placed in 5mL of the hydration liquid, and hydrated at 40℃ for 3h, and the hydration liquid is replaced every hour during the hydration process, and the hydrated colorblind and weak color vision correcting contact lenses are placed in pure water for hydration for 2h and then stored in standard saline.

[0084] Figure 5 The hydration treatment effect diagram under different time conditions in Example 5 is shown in Figure 5 It can be seen that the residual colorblind dye which is not polymerized with the lens raw material can be analyzed out by using the hydration liquid in Example 5 to hydrate the colorblind and weak color vision correcting contact lenses for 3h.

[0085] Example 6

[0086] N,N-dimethylformamide and water were mixed, and anionic polyacrylamide was added to the obtained aqueous N,N-dimethylformamide solution, which was stirred at room temperature for 3 h to obtain a hydration solution; the volume ratio of N,N-dimethylformamide to water in the hydration solution was 60:40, and the mass fraction of anionic polyacrylamide was 0.5%;

[0087] The color-blindness-correcting contact lenses were placed in 5 mL of the hydration solution, and hydration treatment was performed at 80°C for 4 h, during which the hydration solution was replaced every hour. The color-blindness-correcting contact lenses after hydration treatment were placed in pure water for hydration for 2 h and then in standard saline for storage.

[0088] Figure 6 The hydration treatment effect diagram under different time conditions in Example 6 is shown in FIG. 2. Figure 6 It can be seen that the color-blindness-correcting contact lenses are subjected to hydration treatment for 4 h using the hydration solution in Example 6, and the residual color-blindness dye that is not polymerized with the lens raw material can be completely analyzed out.

[0089] Example 7

[0090] Acetone and water were mixed, and anionic polyacrylamide was added to the obtained aqueous acetone solution, which was stirred at room temperature for 3 h to obtain a hydration solution; the volume ratio of acetone to water in the hydration solution was 50:50, and the mass fraction of anionic polyacrylamide was 2.5%;

[0091] The color-blindness-correcting contact lenses were placed in 5 mL of the hydration solution, and hydration treatment was performed at 40°C for 3 h, during which the hydration solution was replaced every hour. The color-blindness-correcting contact lenses after hydration treatment were placed in pure water for hydration for 2 h and then in standard saline for storage.

[0092] Figure 7 The hydration treatment effect diagram under different time conditions in Example 7 is shown in FIG. 3. Figure 7 It can be seen that the color-blindness-correcting contact lenses are subjected to hydration treatment for 3 h using the hydration solution in Example 7, and the residual color-blindness dye that is not polymerized with the lens raw material can be completely analyzed out.

[0093] Example 8

[0094] Acetonitrile and water were mixed, and sodium citrate was added to the obtained aqueous acetonitrile solution, which was stirred at room temperature for 3 h to obtain a hydration solution; the volume ratio of acetone to water in the hydration solution was 70:30, and the mass fraction of anionic polyacrylamide was 2.5%;

[0095] The colorblindness-correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at 60°C for 3 h. The hydration solution is replaced every hour during the hydration process. The hydrated colorblindness-correcting contact lenses are placed in pure water for 2 h and then are stored in standard saline.

[0096] Figure 8 The graph of the hydration treatment effect at different time conditions in Example 8 is shown in FIG. 1. Figure 8 As can be seen from FIG. 1, the colorblindness-correcting contact lenses are hydrated in the hydration solution in Example 8 for 3 h, and the residual colorblindness dye that is not polymerized with the lens raw material is completely analyzed.

[0097] Comparative Example 1

[0098] The propylene glycol and water are mixed in a volume ratio of 60:40 to obtain the hydration solution.

[0099] The colorblindness-correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at room temperature for 36 h. The hydration solution is replaced every hour during the hydration process. The hydrated colorblindness-correcting contact lenses are stored in standard saline.

[0100] Figure 9 The graph of the hydration treatment effect at different time conditions in Comparative Example 1 is shown in FIG. 2. Figure 9 As can be seen from FIG. 2, the colorblindness-correcting contact lenses are hydrated in the hydration solution in Comparative Example 1 for 36 h, and the residual colorblindness dye that is not polymerized with the lens raw material is not completely analyzed.

[0101] Comparative Example 2

[0102] The sodium citrate and water are mixed, and are stirred at room temperature for 3 h to obtain the hydration solution.

[0103] The colorblindness-correcting contact lenses are placed in 5 mL of the hydration solution, and are hydrated at room temperature for 72 h. The hydration solution is replaced every hour during the hydration process.

[0104] Figure 10 The graph of the hydration treatment effect at different time conditions in Comparative Example 2 is shown in FIG. 3. Figure 10 As can be seen from FIG. 3, the colorblindness-correcting contact lenses are hydrated in the hydration solution in Comparative Example 2 for 72 h, and the residual colorblindness dye that is not polymerized with the lens raw material is not completely analyzed.

[0105] Comparative Example 3

[0106] The propylene glycol and water are mixed, and the sodium citrate is added to the obtained propylene glycol aqueous solution. The mixture is stirred at room temperature for 5 h to obtain the hydration solution. The volume ratio of propylene glycol to water in the hydration solution is 10:90, and the mass fraction of the sodium citrate is 2.5%.

[0107] The colorblindness and weak color vision correction contact lenses are placed in 5 mL of the hydration solution, and hydration treatment is carried out at room temperature for 72 h, and the hydration solution is replaced every hour during the hydration treatment.

[0108] Figure 11 The hydration treatment effect diagram at different time conditions in Comparative Example 3 is shown in Figure 11 It can be seen that the colorblindness and weak color vision correction contact lenses are hydrated in the hydration solution in Comparative Example 3 for 72 h, and the residual colorblindness dye that is not polymerized with the lens raw material is still not completely analyzed out.

[0109] Comparative Example 4

[0110] Propylene glycol is mixed with water, and sodium citrate is added to the obtained propylene glycol aqueous solution, and stirring is carried out at room temperature for 5 h to obtain a hydration solution; the volume ratio of propylene glycol to water in the hydration solution is 90:10, and the mass fraction of sodium citrate is 2.5%;

[0111] The colorblindness and weak color vision correction contact lenses are placed in 5 mL of the hydration solution, and hydration treatment is carried out at room temperature for 24 h, and the hydration solution is replaced every hour during the hydration treatment.

[0112] Figure 12 The hydration treatment effect diagram at different time conditions in Comparative Example 4 is shown in Figure 12 It can be seen that the colorblindness and weak color vision correction contact lenses are hydrated in the hydration solution in Comparative Example 4 for 24 h, and the residual colorblindness dye that is not polymerized with the lens raw material is still not completely analyzed out.

[0113] The above only describes the preferred embodiments of the present application, and it should be noted that, for ordinary skilled in the art, without departing from the principles of the present application, a number of improvements and refinements can be made, and these improvements and refinements should also be considered as the protection scope of the present application.

Claims

1. A hydration solution for correcting color blindness and weakness of lenses, comprising an organic solvent, an anionic surfactant and water, wherein the volume ratio of the organic solvent to water is (3-7) : (3-7), the mass fraction of the anionic surfactant is 0.5-5%, the lens for correcting color blindness and weakness is a hydrogel lens and the dye used is a cationic dye, the anionic surfactant is a citrate or an anionic polyacrylamide, and the cationic dye has the structure shown in formula I: wherein A is an olefin group, an olefin derivative group or a group having the structure shown in formula II: wherein R1 is -H or an alkyl group, and n is an integer of 0-20; and the olefin derivative group contains at least one of a carbonyl group, an alkoxy group, an amido group, an aromatic group and a heterocyclic ring. Formula I; R in formula I is A is a substituent containing at least one unsaturated double bond; the organic solvent is one or more of alcohol, dimethyl sulfoxide, N , N dimethylformamide, acetone and acetonitrile; the alcohol is one or more of ethanol, propanol, propylene glycol and glycerol.

2. The corrective colorblindness and color weakness lens hydrating solution of claim 1, wherein, The lens for correcting color blindness and weakness is a contact lens for correcting color blindness and weakness. Formula II; 4.A hydration method for a lens for correcting color blindness and weakness, comprising the following steps: mixing the lens for correcting color blindness and weakness with a hydration solution to perform hydration treatment; and the hydration solution is the hydration solution for correcting color blindness and weakness according to any one of claims 1-3.

3. The corrective colorblindness and color weakness lens hydrating solution of claim 1, wherein, The temperature of the hydration treatment is 20-100℃, and the time is 0.5-8h. The hydration solution is replaced every 0.5-2h during the hydration treatment. ​ 5. The hydration method of claim 4, wherein, ​ 6. The hydration method of claim 4 or 5, wherein, ​

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