Mammalian early pregnancy detection markers and uses thereof

By using serum amyloid A as a biomarker, ELISA or colloidal gold detection technologies have been developed, filling the gap in early pregnancy detection in ewes, enabling earlier pregnancy detection, reducing costs, improving reproductive efficiency, and reducing production losses.

CN116660542BActive Publication Date: 2026-02-06CHINA AGRI UNIV
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Patent Information

Application Number
CN202310417914.7
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-04-18
Publication Date
2026-02-06
Estimated Expiration
2043-04-18

AI Technical Summary

Technical Problem

The lack of effective early pregnancy detection methods in existing technologies leads to improper management of ewes, increasing breeding costs and production losses, and existing methods are rarely used in sheep.

Method used

Using serum amyloid A as a biomarker for early pregnancy in mammals, an early pregnancy detection kit was developed using ELISA or colloidal gold detection technology, which can detect pregnancy approximately 21 days after mating.

Benefits of technology

It enables earlier pregnancy detection, reduces breeding costs, improves ewe reproductive efficiency, reduces the rate of non-pregnant women, optimizes ewe management, reduces the risk of miscarriage and dystocia, and increases production profits.

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Abstract

The present application discloses a protein marker for early pregnancy detection of mammals, and particularly relates to a hidden marker protein serum amyloid A of early pregnancy test paper. Protein sequencing used in the present application adopts liquid chromatography-mass spectrometry (LC-MS) technology, sample correlation is compared through Venn, sample correlation, PCA and PLS-DA analysis; protein function annotation is carried out through GO, KEGG, COG and Pfam, and subcellular localization prediction is carried out; difference protein, protein set and difference metabolite are calculated and counted; correlation analysis of proteome and transcriptome is carried out, difference protein of sheep serum in early pregnancy is obtained, and a key marker protein of early pregnancy of sheep is screened, which provides a basis for unknown early pregnancy detection of sheep.
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Citation Information

Patent Citations

  • Method for diagnosing canine pregnancy and diagnostic reagent therefor

    US20210140952A1