Improved patch

Abstract

The method for preparing the patch includes the following steps: (1) providing a carrier material; (2) coating the underside of the carrier material with a suitable non-UV-curable acrylic adhesive, the adhesive being a solution of polyacrylate in an organic solvent or solvent mixture, the amount of solvent or solvent mixture being 25% to 70% by weight; (3) assembling the patch; and (4) forming a mesh structure on the patch such that it comprises a plurality of intersecting strips. According to the invention, the adhesive is applied at a temperature of 90°C to 120°C for 5 to 60 seconds, and the patch is activated by repeatedly irradiating the underside with ultraviolet light before and / or after the application of the adhesive.

Description

[0001] introduction

[0002] This invention relates to the field of pharmaceutical technology. More specifically, this invention relates to a method for manufacturing an improved patch, and a patch manufactured by the method.

[0003] Existing technology and shortcomings

[0004] Quick-dressing wound dressings, also known as adhesive bandages, plasters, or simple patches, are well-known in the art. They are used to cover minor wounds. They protect minor wounds, for example, by reducing the risk of contamination from impurities entering the wound and / or preventing leakage of blood or wound fluid.

[0005] This type of patch includes a carrier material, which is typically rectangular, circular, or elliptical. An adhesive layer is provided, at least partially, on the underside facing the wound. This layer serves to removably attach the patch to the skin surrounding the wound. For example, in the case of a hot compress, the entire underside can also be self-adhesive. In the central area of ​​the underside, there is often a non-adhesive wound dressing, as it is in contact with the actual wound.

[0006] Patches are also known to accelerate the healing of covered wounds by keeping active substances ready in their wound pads. These active substances are gradually released and absorbed by the tissue through the wound.

[0007] Active substances are also known to be used to prevent itching caused by insect bites. Therefore, wound dressings containing active substances that prevent or relieve itching are known.

[0008] The disadvantages of these patches are that, due to their multilayered nature, their structure is more complex, and the active ingredients undergo a certain aging process and / or can only be stored within a specific narrow temperature range. Another disadvantage is that such patches typically require aseptic packaging to prevent infection from contaminated patches.

[0009] The task and solution of the present invention

[0010] Therefore, the object of the present invention is to provide a method for manufacturing patches and patches manufactured by the method, which avoids the disadvantages of the prior art.

[0011] Accordingly, the patch should have a simple structure, and its effectiveness against itching caused by insect bites should be largely independent of storage conditions and storage time.

[0012] The problem is solved by the method for manufacturing the patch according to claim 1 and the patch according to independent claim 15. Advantageous embodiments can be found in the various dependent claims, the following description, and the drawings.

[0013] Detailed description

[0014] First, a method for manufacturing an improved patch according to the present invention is described. Then, the patch manufactured by the method of the present invention is described.

[0015] This invention relates to a method of manufacturing a patch for relieving itching and / or swelling caused by insect bites. These symptoms are a particularly common side effect of such bites; although they are usually not dangerous, they are unpleasant and often take a relatively long time to subside. During their presence, itching leads to a corresponding scratching response in the affected person, which further delays the healing of the swelling.

[0016] The method includes the following steps:

[0017] 1) Provide an organic carrier material for coating with adhesives, preferably including rayon, polyurethane, or polyester carrier materials. The carrier material ensures the physical integrity of the patch. It preferably has a thickness of 0.1 mm to 1.0 mm, more preferably 0.25 mm. It is particularly preferably elastic, having a modulus of elasticity (Young's modulus) preferably from 0.05 GPa to 5 GPa at a temperature of about 20°C to 40°C, and more preferably from 0.5 GPa to 2.0 GPa, and particularly preferably from about 1.6 GPa at a temperature of 22°C.

[0018] 2) Coat the underside of the carrier material with a non-UV-curable acrylate adhesive suitable for bonding it to human skin, using a solution of polyacrylate in an organic solvent or solvent mixture as the adhesive, wherein the amount of solvent or solvent mixture is 25-70% by weight, preferably 30-60% by weight, based on the total weight of the acrylate adhesive.

[0019] Based on the total weight of the acrylate adhesive, the solvent or solvent mixture is particularly preferably used in an amount of 40 to 55% by weight.

[0020] The organic solvent or solvent mixture contained in the adhesive preferably comprises at least one solvent selected from ethyl acetate, 2-propanol, heptane, toluene, and 2,4-pentanedione. According to a further preferred embodiment, the solvent is selected from isopropanol, heptane, and ethyl acetate. Preferably, a solvent mixture consisting of at least 90% by weight of ethyl acetate, 2-propanol, and / or heptane is used. If toluene and / or 2,4-pentanedione are used, their proportion in the solvent mixture preferably does not exceed 10% by weight, and the proportion of 2,4-pentanedione is preferably 0.3% to 5% by weight. A solvent mixture comprising isopropanol, heptane, and ethyl acetate is particularly preferred. A solvent mixture comprising isopropanol, heptane, ethyl acetate, toluene, and 2,4-pentanedione is even more preferred. A solvent mixture comprising 30-35% by weight of isopropanol, 30-35% by weight of heptane, 30-35% by weight of ethyl acetate, 3-9.5% by weight of toluene, and 0.5-2% by weight of 2,4-pentanedione is preferred.

[0021] The acrylic polymers used according to the invention are preferably acrylic copolymers, i.e., they are preferably composed of at least two different monomer units. Because it is used in solution, it is not a hot melt adhesive. There are no further limitations other than selecting acrylic polymers that are completely soluble in organic solvents or solvent mixtures. It has thus been shown that a variety of acrylic polymers can be used according to the invention. Therefore, the effects of the invention appear to be based on a combination of all the features stated in the independent claims.

[0022] The underside is the side that comes into contact with the skin during use. The adhesive has the function of permanently but removably adhering the patch to the skin. In this document, "permanent" means for at least a few hours up to a few days. Preferably, the adhesive should be harmless for even prolonging contact with the skin. Advantageously, it should be able to be removed from the skin along with the carrier material without leaving any residue and without applying too much tension. Preferably, the underside of the carrier material is completely coated with the adhesive.

[0023] 3) Cut the patch to a size suitable for covering the area from which the itching originates. In this context, "suitable" means that the patch size exceeds the typical size of swelling caused by an insect bite by at least 0.5 cm, preferably 1-2 cm. Therefore, the patch size is at least 2×2 cm to 10×10 cm. The geometry can be, for example, rectangular, circular, or elliptical. "Cutting" refers to reducing or separating the patch, which typically comes from a large sheet or a wide or at least long roll, to the desired external size. This can be done, for example, by punching, mechanical cutting, or laser cutting.

[0024] 4) Create a mesh structure on the patch to include multiple intersecting strips (“structured”). The “mesh structure” includes gaps created due to the lack of material between the strips. Therefore, gaps are created in the surface of the substrate (subtractive processing), thereby forming the mesh structure. It is characterized by the regular repetition of these gaps. Clearly, any excess material created by inserting these gaps must also be removed and discarded. The structure can also be accomplished, for example, by punching, mechanical cutting, or laser cutting.

[0025] Alternatively, a grid structure can be formed by spacing the strips apart by placing them adjacent to each other on top of each other in an appropriate manner (additive processing).

[0026] A grid structure can also be formed by configuring multiple randomly intersecting strips, which can be linear or curved, and connecting them together at the intersections; gaps are also formed in this structure.

[0027] The mesh structure leads to a decrease in the (overall) E-modulus of the patch because the amount of material available in the corresponding direction is smaller and the width of the gaps in the stretched direction is reduced.

[0028] According to the invention, the adhesive is applied to the carrier material for 5 to 60 seconds at a temperature of 45°C to 155°C. Under these conditions, any solvent present in the adhesive evaporates almost completely, preferably completely. Preferably, the temperature is 90°C to 120°C, more preferably 105°C. The application time is preferably 10 to 30 seconds, particularly preferably 20 seconds. Tests have surprisingly shown that patches in which the adhesive has been applied using the above parameters exhibit particularly good performance in terms of antipruritic and / or anti-swelling effects, because the mechanical properties of the patch are thus affected in a particularly advantageous manner.

[0029] According to the present invention, the patch is also activated by repeatedly irradiating the lower side with ultraviolet light.

[0030] Irradiation is preferably performed at a wavelength of 100-380 nm. The cumulative irradiation time is preferably 0.01-2 seconds, and particularly preferably by several, especially 3-5 consecutive short light pulses. The time between pulses is preferably such that the temperature of the irradiated surface drops back to room temperature (21°C ± 5°C).

[0031] Preferably, UV-A light (wavelength from 380 nm to 315 nm) is used first, followed by UV-B light (wavelength from 315 nm to 280 nm) and / or UV-C light (wavelength from 280 nm to 100 nm).

[0032] Irradiation can be performed before or after the application of the adhesive. If the patch is irradiated before coating, the underside of the carrier material is prepared for adhesive application, which in turn has a positive effect on the mechanical properties of the patch.

[0033] If irradiation occurs after the adhesive is applied, the adhesive itself, especially the side intended to contact the skin, is also altered in a beneficial way, which also has a positive effect on the mechanical properties of the patch, particularly on the "composite system" of the patch and the skin.

[0034] Irradiation can also be performed before and after the application of the adhesive in order to combine the aforementioned advantages.

[0035] Irradiation also affects the stress modes in the irradiated material. Irradiation with different wavelengths results in different penetration depths, which in turn lead to different mechanical stress modes at these depths.

[0036] As described above, the features of "temperature" and "irradiation" are preferably combined. In this way, the mechanical properties of the patch and the "composite system" of the patch and skin are optimally improved. Therefore, once the patch is applied to the affected area, the patch's effectiveness in relieving itching and / or swelling is enhanced.

[0037] The addition of known antipruritic and / or swelling-relieving agents can be omitted. It has been shown that patches manufactured by this method are suitable for relieving itching and / or swelling caused by insect bites, even without such agents. Therefore, in a preferred embodiment of the method, neither drugs nor active ingredients are added during the manufacture of the patch. The positive effects of the patch have been shown to be particularly attributable to the above-described measures. Therefore, the patch of the present invention preferably also does not contain drugs or active ingredients.

[0038] Therefore, the present invention avoids the disadvantages known in the prior art. The patch according to the invention is very simple in construction due to its possible and particularly preferred monolayer structure, which simplifies the manufacturing process and reduces costs. Pharmaceutical active ingredients can be completely omitted. Therefore, the patch can be stored for up to 5 years before use. Simultaneously, it is significantly less sensitive to particularly high or low storage temperatures. Furthermore, the manufacturing method according to the invention improves the mechanical properties of the patch, and thus improves its antipruritic and / or anti-swelling effects.

[0039] Various embodiments of the present invention are described in more detail below.

[0040] It should be noted that trimming steps can be performed before, after, and during the mesh fabrication process. Trimming before or after mesh fabrication (subtractive or additive structuring) causes the stress induced by machining to shift towards the center or edges of the patch. By simultaneously trimming and structuring, the stress tends to be balanced across the entire patch. The stress state of the patch can also be effective when it is applied to the skin.

[0041] Particularly preferably, the cutting step is performed before or after the structuring step, i.e., not simultaneously with the structuring step, while the carrier material is always arranged such that its underside is coated with an acrylic adhesive on the protective film. Therefore, the associated machining is two-stage in time. The protective film, which can be in the form of release paper, ensures its ease of initial structuring (i.e., creating gaps) and only subsequent cutting (i.e., separating the patches from each other), or vice versa.

[0042] Particularly preferably, between the two steps of “structuring” and “cutting,” a heat treatment of the product is performed at a temperature of 30°C to 90°C, preferably about 60°C, for 2 to 120 seconds, preferably 5 to 30 seconds, and particularly preferably about 10 seconds. This treatment causes relaxation of the areas (edges) that have already been treated by cutting or punching. Conversely, such treatment is not repeated after subsequent further steps, so that the stress introduced by these further steps remains on the areas treated during those steps. In this way, the patch has different internal stresses in its peripheral areas (outer edges) than in its internal areas (gap areas). Since the carrier material is placed on and held on the protective film until it is used, this ensures that once stress is generated, the stress state is maintained for a long time, because the carrier material cannot move or wrinkle, for example, to compensate for the stress gradient between the internal areas and the edges. Since the patch is typically applied to the skin immediately after being removed from the protective film, the internal tension is not substantially released during this short period; instead, it is transferred to the user's skin, where it contributes to the desired effect of relieving itching.

[0043] Particularly preferably, the activation is performed on the applied adhesive layer by emitting ultraviolet light with a first pulse of 5s ± 1s, followed by a first pause of 10s ± 2s, a second pulse of 5s ± 1s, a second pause of 10s ± 2s, and a third pulse of 2.5s ± 0.5s. The dose irradiated onto the adhesive is preferably 0.1 mJ / cm². 2 Up to 1000mJ / cm 2 Its preferred amount is 20 mJ / cm³. 2 Up to 200mJ / cm 2 Its preferred value is 85 mJ / cm. 2±15%. The repeated heating and cooling of the adhesive associated with this sequence achieves a particularly advantageous bond between the latter and the carrier material, and (later) between the adhesive and the skin. Furthermore, the particularly advantageous results of the aforementioned activation are achieved.

[0044] The total radiation dose should be 0.1 mJ / cm². 2 Up to 1000mJ / cm 2 Preferably, it is 5 mJ / cm. 2 Up to 500mJ / cm 2 Particularly preferred is 20 mJ / cm³. 2 Up to 200mJ / cm 2 Preferably, it is 85 mJ / cm. 2 ±15%

[0045] According to one embodiment, the grid structure consists of three preferred vertical strips and four preferred horizontal strips. Each strip is approximately 3 mm wide. The gaps between the strips are 3 mm × 3 mm wide. This results in a total width of 21 mm and a length of 27 mm.

[0046] Other preferred embodiments have dimensions of 36mm × 28mm, a strip width of 4mm, and are also 4 × 3 strips, or have dimensions of 52mm × 44mm with 6 × 5 strips.

[0047] According to another embodiment, the vertical and horizontal strips are at a 90° angle to each other. This results in a right-angled pattern. Therefore, the tool for creating the gap is positioned (e.g., a punching tool) or adjusted (e.g., a cutting laser) accordingly to produce the desired angle. The gap is then rectangular, for example, specifically a square. The advantage of this embodiment is the same elastic modulus in the two principal tensile directions (the principal tensile directions are two tensile directions located in the patch plane and perpendicular to each other). This is advantageous when the patch is applied to a skin area that extends approximately equally in all directions, since the patch's position is not significant.

[0048] According to alternative embodiments, the vertical and horizontal strips are angled relative to each other at 7°, 30°, 42°, 45°, 60°, or 75°. This results in gaps with a diamond shape. Depending on the angle, these diamonds are more or less flat. The advantage of this design lies in the different elastic moduli in the two principal tensile directions. When the patch is applied to skin areas with different elongations, this embodiment can be used to achieve different mechanical responses depending on the location on the skin.

[0049] According to another embodiment, the grid structure consists of three or more groups of strips, each group extending parallel to each other. Each group forms an angle with the remaining groups, so no group is parallel to another group. Then, in the case of three groups, the gaps have a triangular shape; in the case of five groups, the gaps have a pentagonal shape, and so on. Three groups are particularly preferred. The advantage of this embodiment is that it provides three directions with higher elastic modulus and three additional directions with lower elastic modulus, which may be ideal in certain applications.

[0050] According to a preferred embodiment, each strip terminates at removable portions on both sides. "Both sides" refers to the removable portions at the beginning and end of the strip. These removable portions lead to the non-linear edges of the patch. For example, when the patch's cover is rectangular, the actual outline is defined by the removable portions. Alternatively, this structure can be formed by placing the outermost gaps such that their outer edges coincide with the outer edge of the patch's cover, or even by placing these gaps to overlap with the outer edge. The advantage of this design is that it further improves the interaction between the patch and the skin.

[0051] Preferably, the edges of each detachable section are at a 90° angle to each other. Experiments have shown that edges shaped in this manner achieve particularly good working results. When the patch is applied to the skin, the corners of these sections cause tension concentration, which further enhances effectiveness.

[0052] According to an alternative embodiment, the ends of each detachable portion taper at an angle of 10° to 170°. This means that the portions form "arrows" pointing away from the center of the patch. The tips of these arrows also cause tension concentration when the patch is applied to the skin, further improving effectiveness.

[0053] In another embodiment, the ends of each detachable part are rounded. In some cases, the aforementioned stress concentration can be detrimental, which can be avoided by using rounded ends.

[0054] According to another embodiment of the invention, the adhesive is dispensed at a pressure of 1 bar to 10 bar, preferably 2 bar to 6 bar, more preferably 3.057 bar to 5.095 bar, and most preferably 4.076 bar ± 0.05 bar. This means that a liquid or paste-like adhesive from a dispensing device such as a nozzle is dispensed at the aforementioned pressure. Alternatively, the pressure can be provided by applying it in an atmosphere having said pressure. Dispensing the adhesive at said pressure results in improved adhesion between the adhesive and the carrier material, which in turn has a beneficial effect on the mechanical properties of the patch.

[0055] According to another embodiment, the adhesive is applied at a surface pressure of 200 kPa to 600 kPa, preferably 300 kPa to 500 kPa, particularly preferably 400 kPa, ±1% in each case. This corresponds to 2.03 kg / cm². 2 Up to 6.1 kg / cm 2 3.1 kg / cm² is preferred. 2 Up to 5.1 kg / cm 2 4.1kg / cm² is particularly preferred. 2 The value of this surface pressure can be generated, for example, by a transfer plate after wetting the substrate, and can be maintained for at least 0.5 seconds, preferably at least 2 seconds, and particularly preferably 3-5 seconds. In this way, good adhesion is achieved between the adhesive and the carrier material.

[0056] According to a further preferred embodiment, the solvent is selected from isopropanol, heptane, and ethyl acetate.

[0057] The present invention also relates to a patch for relieving itching and / or swelling caused by insect bites, the patch being manufactured by the method described above. The advantages arising from the shaping and processing during the manufacturing process will not be repeated hereafter, but are referred to the preceding sections.

[0058] Particularly preferred are the carrier materials of the patch, including rayon, cellulose acetate, polyurethane, or polyester. These materials are particularly skin-friendly, can be readily constructed and processed by the method according to the invention, and have the aforementioned suitable modulus of elasticity of 0.1 to 1.0. Another advantage of cellulose acetate is its low hygroscopicity; therefore, this fabric-like material tends to become electrostatic. While this effect is generally quite undesirable, it is preferred in the case of this patch because it adheres itself to the skin almost automatically. This effect is more pronounced with thinner and thus more flexible materials.

[0059] The weight percentage of the carrier material (without a protective covering layer) on the patch is preferably 50% to 70%, and the weight percentage of the adhesive is preferably 25% to 30%, more preferably 30% to 50%.

[0060] According to the present invention, the adhesive is an acrylic adhesive (also known as an acrylate adhesive). This adhesive has proven to be particularly skin-friendly; furthermore, it can be applied well under the temperature and pressure conditions provided by the present invention. Surprisingly, it has been shown that although this adhesive is not UV-cured, the aforementioned advantages are achieved through UV light irradiation combined with the method of the present invention.

[0061] Preferably, the acrylic adhesive contains isopropanol, heptane, and ethyl acetate as solvents for the polyacrylate.

[0062] Adhesives containing these substances are particularly suitable for bonding to carrier materials by the method of the present invention. Furthermore, adhesives containing these components have been found to be particularly skin-friendly and pleasantly removable after application. Attached Figure Description

[0063] The invention will now be explained by way of example with the aid of the accompanying drawings. This illustrates...

[0064] Figure 1 A schematic flowchart relating to a method for manufacturing an improved patch;

[0065] Figure 2 A schematic diagram of an embodiment of the patch according to the present invention;

[0066] Figure 3 A schematic diagram of another embodiment of the patch according to the present invention.

[0067] Figure 1 A schematic flowchart of a method for manufacturing an improved patch is shown. In the first step, a carrier material is prepared. An adhesive is then applied to the underside of the carrier material, preferably using the parameters mentioned in the figure regarding temperature, time, pressure, and surface pressure. Structuring (creating a mesh structure) and trimming (separation of the patch from the panel) are then performed. The last two steps can be performed one after the other, as shown, but they can also be performed simultaneously.

[0068] According to the present invention, the underside is activated by UV irradiation before and / or after coating.

[0069] To avoid repetition, please refer to the description above.

[0070] Figure 2 A schematic diagram of an embodiment of the patch 1 according to the present invention is shown. Therefore, the patch 1 has a mesh structure consisting of four vertical strips 2 and three horizontal strips 3. Gaps 4 exist between the strips 2 and 3 (only two gaps are marked with reference numerals). The gaps 4 have the effect of reducing the elastic modulus of the patch (compared to a conventional patch (not shown) without gaps).

[0071] In the example shown, the vertical strip 2 and the horizontal strip 3 are at a 90° angle 5 to each other. Therefore, the gap 4 is rectangular, or in this case, square.

[0072] The embodiment shown in the figure has strips 2 and 3 that terminate on both sides at removable portions 6 (only two removable portions are marked with reference numerals). The edges of each removable portion 6 are at a 90° angle to each other (no reference numerals are shown).

[0073] Figure 3A schematic diagram of another embodiment of the patch 1 according to the invention is shown. This differs from the patch described above in that the vertical strip 2 and the horizontal strip 3 are at an angle to each other other than 90°. In the present case, angle 5 is approximately 68°. This results in different overall moduli of elasticity for the two principal tensile directions X and Y. The moduli of elasticity in the principal tensile direction Y is smaller than that in the principal tensile direction X. Loads in the X direction are primarily absorbed by the strips extending along the X direction, which continue to be loaded along their longitudinal axis. However, when a load is applied in the Y direction, the (tilted) vertical strips are no longer loaded along their longitudinal axis.

[0074] The difference lies in the fact that the gaps are not formed in the substrate by means of punching or laser cutting, but are formed by stacking individual strips spaced apart from each other.

[0075] The embodiment also has strips 2,3 that terminate at removable portions 6 on both sides. However, the edges of each removable portion 6 taper at an angle of approximately 45°, which can cause tension to concentrate at the tip after the patch 1 is applied to the skin (not shown).

[0076] It should be noted that Figure 2 and Figure 3 The variations described herein can also be implemented in a different combination than that exemplified in the described exemplary implementation, since they are not interdependent.

[0077] List of reference numerals

[0078] 1 patch

[0079] 2 Vertical stripes

[0080] 3 Horizontal strips

[0081] 4 gaps

[0082] 5 angles

[0083] 6 Detachable parts

[0084] X Main stretching direction

[0085] Y Main stretching direction

Claims

1. A method for manufacturing a patch (1) for relieving itching and / or swelling caused by insect bites, comprising the following steps: - Provides organic carrier materials that can be coated with adhesives; - The underside of the carrier material is coated with a non-UV-curable acrylate adhesive suitable for bonding the carrier material to human skin, using a solution of polyacrylate in an organic solvent or solvent mixture as the adhesive, wherein the amount of the solvent or solvent mixture is 25% to 70% by weight based on the total weight of the acrylate adhesive. - Cut the patch (1) to a size suitable for covering the area from which the itching and swelling originate; - A mesh structure with gaps is formed on the patch (1), such that it includes multiple intersecting strips (2,3); in - Apply the adhesive at a temperature of 45°C to 155°C for 5 to 60 seconds. - The patch (1) is activated by repeatedly irradiating the underside with ultraviolet light before and / or after the application of the adhesive, and -The solvent is selected from isopropanol, heptane and ethyl acetate.

2. The method according to claim 1, wherein the carrier material comprises rayon, cellulose acetate, polyurethane, or polyester.

3. The method according to claim 1 or 2, wherein the cutting step is performed before or after the structuring step, and the carrier material is always arranged such that its underside is coated with an acrylic adhesive on the protective film.

4. The method according to claim 1 or 2, wherein the activation by ultraviolet light comprises a first pulse of length 5s ± 1s, followed by a first pause of 10s ± 2s, a second pulse of length 5s ± 1s, followed by a second pause of 10s ± 2s, and a third pulse of length 2.5s ± 0.5s.

5. The method according to claim 1 or 2, wherein the energy irradiated onto the adhesive is 85 mJ / cm². 2 ± 15%.

6. The method according to claim 1 or 2, wherein the grid structure consists of vertical strips (2) and horizontal strips (3).

7. The method according to claim 6, wherein the vertical strip (2) and the horizontal strip (3) are at an angle (5) of 90° to each other.

8. The method according to claim 6, wherein the vertical strip (2) and the horizontal strip (3) are at an angle (5) of 7°, 30°, 42°, 45°, 60° or 75° to each other.

9. The method according to claim 1 or 2, wherein the mesh structure comprises three or more groups of strips (2; 3), each strip extending parallel to each other, and wherein each group includes an angle (5) with respect to the remaining groups.

10. The method according to claim 1 or 2, wherein each strip (2, 3) terminates at a detachable portion (6) on both sides.

11. The method of claim 10, wherein the edges of each detachable portion (6) are at an angle (5) of 90° to each other.

12. The method of claim 10, wherein the end of each detachable portion (6) tapers gradually at an angle of 10° to 170°.

13. The method of claim 10, wherein the ends of each detachable portion (6) are rounded.

14. The method according to claim 1 or 2, wherein the pressure is from 3.057 bar to 5.095 bar or at 3.1 kg / cm². 2 Up to 5.1 kg / cm 2 The adhesive is applied under surface pressure.

15. A patch (1) for relieving itching and / or swelling caused by insect bites, wherein the patch (1) is manufactured by the method of any one of claims 1 to 14, and the acrylic adhesive comprises isopropanol, heptane and ethyl acetate.

16. The patch (1) according to claim 15, wherein the carrier material comprises rayon, cellulose acetate, polyurethane or polyester.

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