A water-soluble composition containing ferulic acid, a whitening soothing freeze-dried film containing the same

Abstract

The present application discloses a ferulic acid-containing water-soluble composition, a whitening soothing freeze film containing the same. TM The ferulic acid-containing water-soluble composition of the present application can solve the technical problem that ferulic acid is difficult to dissolve in water only by the specific mass percentage of each component among the conventional polyhydric alcohol moisturizing agent, the thickening moisturizing agent (Hispagel The whitening freeze film of the present application has the effects of moisturizing, whitening and soothing, ferulic acid is dissolved and stable in the transparent and refreshing freeze film system, and the synergistic effect of each component in the formula makes the product have good efficacy and improved skin feel (especially the cleaning feel).

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a water-soluble composition containing ferulic acid and a whitening and soothing gel mask containing the composition. Background Technology

[0002] Ferulic acid, also known as 4-hydroxy-3-methoxycinnamic acid, is a strong oxidizing agent that can effectively scavenge various free radicals such as hydrogen peroxide, superoxide radicals, hydroxyl radicals, and nitroso radicals. It also has sun protection and whitening effects. However, as an organic acid, ferulic acid has extremely poor water solubility, which limits its application in cosmetics.

[0003] Existing technology discloses a stable anti-aging and whitening composition, its preparation method, and its application. It points out that addressing the problem of the difficulty in maintaining 1% ferulic acid stably in cosmetic formulations and the resulting deterioration in formulation stability, a more ideal effect can be achieved by modifying the aqueous-alcohol phase of the formulation. Furthermore, it uses low-content ferulic acid and a specific content of γ-aminobutyric acid (GABA) as the main active ingredients; the combination of these two results in superior antioxidant capacity, a more stable formulation, and less irritation. However, it does not clearly explain whether GABA and the emulsifier contribute to the solubilization of ferulic acid, and the ferulic acid precipitates after cooling when dissolved in polyols and hot water. Therefore, the application of ferulic acid in cosmetics remains a technical challenge.

[0004] Another patent discloses a water-soluble whitening composition formulation, its preparation method, and its uses. It indicates the use of poloxamer 407, polyethylene glycol-32, and sodium polyacrylate as stabilizers, which solves the problem of ferulic acid and salicylic acid being insoluble in water. However, the poloxamer system has a sticky feel, and skin feel is a crucial aspect of cosmetic use; a refreshing, non-sticky, and moisturizing yet lightweight feel provides a better consumer experience. Furthermore, products containing emulsifiers and surfactants are often opaque emulsions, while a clear, translucent appearance is also a reason for consumer appeal. Therefore, optimizing the product's user experience while dissolving ferulic acid is another technical challenge to be addressed. Summary of the Invention

[0005] The present invention aims to at least solve one of the aforementioned technical problems existing in the prior art. Therefore, the object of the present invention is to provide a water-soluble composition containing ferulic acid and a whitening and soothing gel mask containing this composition. This composition uses conventional polyol moisturizers and thickening moisturizers, and by adjusting the specific mass percentages of each component, the technical problem of ferulic acid's poor water solubility can be solved. The gel mask containing this composition, through screening its components, is ultimately prepared into a sheet mask with moisturizing, soothing, and whitening effects, and also has advantages such as a transparent appearance, a refreshing skin feel, and easy washing.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0007] The first aspect of the present invention provides a water-soluble composition containing ferulic acid.

[0008] A second aspect of the present invention provides a method for preparing a water-soluble composition containing ferulic acid.

[0009] A third aspect of the invention proposes the use of a water-soluble composition containing ferulic acid in cosmetics.

[0010] A fourth aspect of the present invention provides a whitening and soothing gel mask.

[0011] The fifth aspect of this invention provides a method for preparing a whitening and soothing gel mask.

[0012] According to a first aspect of the present invention, a water-soluble composition containing ferulic acid is provided, comprising, by weight percentage, the following components: 10-50 parts thickening and moisturizing agent, 10-40 parts polyol, and 0.1-1.0 parts ferulic acid.

[0013] In some embodiments of the present invention, the thickening and moisturizing agent comprises a mixture of water, glycerin, and glyceryl polyacrylate.

[0014] In some embodiments of the present invention, the mass ratio of water, glycerin, and glyceryl polyacrylate in the thickening and moisturizing agent is 4-5:4-5:0.5.

[0015] In some embodiments of the present invention, the thickening and moisturizing agent is Hispagel. TM 200Ns.

[0016] In some embodiments of the present invention, the Hispagel TM 200Ns is sourced from BASF (China) Co., Ltd., and comprises 50wt% water, 45wt% glycerol, and 5wt% glycerol polyacrylate.

[0017] In some embodiments of the present invention, the polyol includes at least one of glycerol, butanediol, and 1,3-propanediol.

[0018] In some preferred embodiments of the present invention, the water-soluble composition containing ferulic acid comprises, by weight percentage, the following components: Hispagel TM 200Ns 10-50%, polyol 10-40%, ferulic acid 0.1-1.0%, balance water.

[0019] In some preferred embodiments of the invention, the water-soluble composition containing ferulic acid comprises, by weight percentage, the following components: Hispagel TM 200Ns 20-30%, polyols 11-21%, ferulic acid 0.11-0.5%, balance water.

[0020] In this invention, the above-mentioned water-soluble composition containing ferulic acid does not contain emulsifiers or surfactants, but only uses conventional polyol humectants and thickening humectants (Hispagel). TM By combining 200N) and water, and through specific mass percentage combinations of the components, the technical problem of ferulic acid's poor water solubility can be solved.

[0021] According to a second aspect of the present invention, a method for preparing the water-soluble composition containing ferulic acid described in the first aspect is provided, comprising the following steps:

[0022] Hispagel will be proportionally TM The product is obtained by mixing 200Ns, polyol, and ferulic acid.

[0023] In some preferred embodiments of the present invention, the method for preparing the water-soluble composition containing ferulic acid includes the following steps:

[0024] Hispagel will be proportionally TM The product is obtained by mixing 200Ns, polyol, ferulic acid, and water.

[0025] In some preferred embodiments of the present invention, the mixing includes heating and stirring at 80°C to 85°C.

[0026] According to a third aspect of the invention, the application of a water-soluble composition containing ferulic acid in cosmetics is proposed.

[0027] In some embodiments of the present invention, the water-soluble composition containing ferulic acid is added to the cosmetic at a mass percentage of 11 to 50%.

[0028] According to a fourth aspect of the present invention, a whitening and soothing gel mask is provided, comprising the following components: a water-soluble composition containing ferulic acid, panthenol, hydroxyethylpiperazine ethanesulfonic acid, glyceryl polyether-26, polyacrylate crosspolymer-6, and SymCalmin.

[0029] In some embodiments of the present invention, the SymCalmin comprises 48 wt% 1,2-pentanediol, 47.9 wt% butanediol, 4 wt% hydroxyphenylpropionamide benzoic acid, and 0.1 wt% ascorbyl palmitate.

[0030] In some embodiments of the present invention, the components include the following parts by weight: 11-50 parts of a water-soluble composition containing ferulic acid, 0.1-0.5 parts of panthenol, 0.1-0.5 parts of hydroxyethylpiperazine ethanesulfonic acid, 0.5-3 parts of glycerol polyether-26, 0.01-1.0 parts of polyacrylate crosspolymer-6, and 0.2-0.3 parts of SymCalmin.

[0031] In this invention, polyacrylate crosspolymer-6 serves as a thickener, providing some stability to the frozen film formulation system; panthenol has a soothing effect; SymCalmin has an anti-allergic effect; hydroxyethylpiperazine ethanesulfonic acid has a certain penetration-enhancing effect, and its presence also contributes to the stability of ferulic acid in the system; glycerol polyether-26 has moisturizing and lubricating effects, improving the skin feel and cleansing feel of the frozen film. Furthermore, when the thickener / moisturizer in the water-soluble composition of ferulic acid contains glycerol polyacrylate, it exhibits solubilizing and stabilizing effects in the system. In addition to the above components, some preservatives, fragrances, and other conventional additives or auxiliaries in the art can also be added.

[0032] In some preferred embodiments of the present invention, the whitening and soothing gel mask containing a water-soluble composition containing ferulic acid further includes an auxiliary agent, which, by weight, includes 0.3 to 0.5 parts of p-hydroxyacetophenone and 0.6 to 0.8 parts of 1,2-hexanediol.

[0033] According to a fifth aspect of the present invention, a method for preparing a whitening and soothing gel mask according to the fourth aspect is provided, comprising the following steps:

[0034] Mix the water-soluble composition containing ferulic acid, panthenol, hydroxyethylpiperazine ethane sulfonic acid, and polyacrylate crosspolymer-6 in a certain proportion, heat and stir at 80℃~85℃, cool to 35℃~45℃, add glycerol polyether-26 and SymCalmin, and stir to obtain the final product.

[0035] or

[0036] Mix the water-soluble composition containing ferulic acid, panthenol, hydroxyethylpiperazine ethane sulfonic acid, polyacrylate crosspolymer-6, and p-hydroxyacetophenone in a certain proportion, heat and stir at 80℃~90℃, cool to 35℃~45℃, add glycerol polyether-26, 1,2-hexanediol and SymCalmin, and stir to obtain the final product.

[0037] The beneficial effects of this invention are:

[0038] The water-soluble composition containing ferulic acid of the present invention uses only conventional polyol moisturizers and thickening moisturizers, and solves the technical problem of ferulic acid being difficult to dissolve in water by using specific mass percentages of each component.

[0039] The whitening gel mask of the present invention, containing a water-soluble composition with ferulic acid, achieves moisturizing, whitening, and soothing effects by adding moisturizing, whitening, soothing, and penetration-enhancing ingredients. Furthermore, ferulic acid is soluble and stable in a transparent and refreshing gel mask system. It was also unexpectedly discovered that the addition of hydroxyethylpiperazine ethane sulfonic acid and glyceryl polyether-26 not only enhances the product's efficacy but also improves its skin feel (especially its cleansing feel). Attached Figure Description

[0040] Figure 1 This indicates that ferulic acid is almost insoluble to the naked eye;

[0041] Figure 2 The condition shows slight precipitation of ferulic acid as observed by the naked eye;

[0042] Figure 3 This is a visual observation of ferulic acid that has almost completely precipitated out after dissolution;

[0043] Figure 4 This refers to the condition of completely dissolved ferulic acid as observed by the naked eye. Detailed Implementation

[0044] The present invention will be further described in detail below through specific embodiments. Unless otherwise specified, the raw materials, reagents, or apparatus used in the embodiments and comparative examples are all available from conventional commercial sources or can be obtained by existing technical methods. Unless otherwise specified, the test or experimental methods are conventional methods in the art.

[0045] The sources of the raw materials used in the following embodiments and test examples are as follows:

[0046] SymCalmin is sourced from Symrise Fragrance & Flavor (Nantong) Co., Ltd., and its main components are: 48wt% 1,2-pentanediol, 47.9wt% butylene glycol, 4wt% hydroxyphenylpropionamide benzoic acid, and 0.1wt% ascorbyl palmitate.

[0047] Hispagel TM 200Ns is sourced from BASF (China) Co., Ltd., and its main components are 50wt% water, 45wt% glycerol, and 5wt% glycerol polyacrylate.

[0048] Ferulic acid is sourced from Nanjing Speco Biotechnology Co., Ltd.

[0049] Hydroxyethylpiperazine ethane sulfonic acid is sourced from Polyhe International Co., Ltd.

[0050] Glyceryl polyether-26 is sourced from Vantage Specialty Chemicals Inc.

[0051] Experimental Example 1

[0052] The solubility of ferulic acid in compositions formed with glycerol, butylene glycol, 1,3-propylene glycol and glycerol polyacrylate in different proportions was tested, and the stability of the samples was analyzed. The results are shown in Table 1.

[0053] Specifically: Weigh ferulic acid, polyol, water, and Hispagel according to the mass percentages in Table 1. TM 200 Ns. Heat to 85℃, stir well, and hold for 15 min. After cooling to 25℃, observe the precipitation of ferulic acid in the sample. Precipitation immediately after cooling indicates almost no dissolution. Observe the dissolution of ferulic acid in the sample after 24 h. Precipitation indicates that ferulic acid has dissolved and precipitated; a small amount of precipitation indicates partial dissolution or slight precipitation. For well-dissolved samples, continue to place them in a low-temperature (-15℃) environment for another 24 h and observe the dissolution of ferulic acid. No precipitation or complete dissolution indicates that the stability has passed. See the above criteria for judging the different dissolution states and degrees. Figures 1-4 .

[0054] Table 1. Compositions containing ferulic acid and their stability results

[0055]

[0056]

[0057] Note: ××× indicates almost no dissolution; ×× indicates precipitation after dissolution; × indicates slight precipitation; √ indicates stability passed.

[0058] The experiment revealed that sample 1 did not precipitate after dissolving ferulic acid, while 75% of Hispagel in sample 1... TM200Ns contains 33.75% glycerol and 3.75% glyceryl polyacrylate. Experiment 2 involved dissolving ferulic acid in 35% glycerol and water alone; almost all of it precipitated upon cooling. Experiment 3 replaced glycerol with butanediol. Due to its better solubility, 35% butanediol and water could dissolve 0.5% ferulic acid, but precipitation began at 20% butanediol. Simultaneously, experiments using 1,3-propanediol yielded similar results. Experiments 4, 5, 7, and 8 show that butanediol and 1,3-propanediol have better solubility for ferulic acid than glycerol; however, ferulic acid still precipitates when the amount of butanediol used is below 20% or the amount of 1,3-propanediol used is below 15%. Therefore, it can be concluded that glyceryl polyacrylate contributes to the solubility and stability of ferulic acid. In practical applications, the usage of butylene glycol and 1,3-propylene glycol in most cosmetics is typically around 5% to 15%. Therefore, for products using ferulic acid at concentrations above 0.5%, stability remains an issue. Samples 9 and 10 used 25% Hispagel... TM At 200 Ns, 20% and 25% glycerol were added respectively. It was found that adding 25% glycerol resulted in stable dissolution of ferulic acid, with complete dissolution and no precipitation. Sample 6 showed that 10% butylene glycol and 25% Hispagel... TM 200 Ns can also dissolve 0.5% ferulic acid. The results for sample 12 indicate that when polyols or Hispagel... TM When the amount of 200Ns added is below a certain value, the stability of the sample fails to pass the test.

[0059] Example 1

[0060] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.5%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0061] The specific preparation process is as follows:

[0062] Weigh each component according to the proportions, including glycerol, butylene glycol, and Hispagel. TMMix 200Ns, ferulic acid, water, polyacrylate crosspolymer-6, panthenol, hydroxyethylpiperazine ethane sulfonic acid, and p-hydroxyacetophenone, heat to 85°C, and homogenize at 1500 r / min for 10 min until the mixture is uniform; cool to 40°C, add glycerol polyether-26, 1,2-hexanediol, and SymCalmin, and homogenize at 1500 r / min for 10 min until the mixture is uniform, and the desired product is obtained.

[0063] Example 2

[0064] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Ferulic acid 0.5%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0065] The specific process is described in Example 1.

[0066] Example 3

[0067] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 20%, Glycerin 20%, Ferulic Acid 0.4%, Panthenol 0.5%, Hydroxyethylpiperazine Ethanesulfonic Acid 0.5%, Glyceryl Polyether-26 3%, Polyacrylate Crosspolymer-6 0.7%, SymCalmin 0.3%, p-Hydroxyacetophenone 0.5%, 1,2-Hexanediol 0.8%, balance water.

[0068] The specific process is described in Example 1.

[0069] Example 4

[0070] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 8%, Butylene glycol 20%, Ferulic acid 0.4%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 1.0%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0071] The specific process is described in Example 1.

[0072] Example 5

[0073] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 5%, Ferulic acid 0.01%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0074] The specific process is described in Example 1.

[0075] Example 6

[0076] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.1%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0077] The specific process is described in Example 1.

[0078] Example 7

[0079] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.5%, Panthenol 0.1%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0080] The specific process is described in Example 1.

[0081] Example 8

[0082] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.5%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.1%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0083] The specific process is described in Example 1.

[0084] Example 9

[0085] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.5%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 0.5%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.3%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0086] The specific process is described in Example 1.

[0087] Example 10

[0088] This embodiment prepares a whitening and soothing gel mask, which, by weight percentage, consists of the following: Hispagel TM 200Ns 25%, Butylene glycol 10%, Glycerin 5%, Ferulic acid 0.5%, Panthenol 0.5%, Hydroxyethylpiperazine ethane sulfonic acid 0.5%, Glyceryl polyether-26 3%, Polyacrylate crosspolymer-6 0.7%, SymCalmin 0.2%, p-hydroxyacetophenone 0.5%, 1,2-hexanediol 0.8%, balance water.

[0089] The specific process is described in Example 1.

[0090] The formulations for Examples 1-5 are shown in Table 2, and the formulations for Examples 6-10 are shown in Table 3.

[0091] Table 2 Formulations of Examples 1-5

[0092]

[0093] Table 3 Formulations of Examples 6-10

[0094]

[0095]

[0096] Comparative Example 1

[0097] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain ferulic acid, while the rest is the same as in Example 1.

[0098] Comparative Example 2

[0099] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain panthenol, while the rest is the same as in Example 1.

[0100] Comparative Example 3

[0101] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain hydroxyethylpiperazine ethanesulfonic acid, while the rest is the same as in Example 1.

[0102] Comparative Example 4

[0103] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain glycerol polyether-26, while the rest is the same as in Example 1.

[0104] Comparative Example 5

[0105] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that SymCalmin was not added, while the rest was carried out in accordance with Example 1.

[0106] Comparative Example 6

[0107] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain panthenol and SymCalmin, while the rest is the same as in Example 1.

[0108] Comparative Example 7

[0109] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain hydroxyethylpiperazine ethanesulfonic acid and SymCalmin, while the rest is the same as in Example 1.

[0110] Comparative Example 8

[0111] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain panthenol and hydroxyethylpiperazine ethanesulfonic acid, while the rest is the same as in Example 1.

[0112] Comparative Example 9

[0113] This comparative example prepared a whitening and soothing gel mask, which differs from Example 1 in that it does not contain ferulic acid and hydroxyethylpiperazine ethanesulfonic acid, while the rest is the same as in Example 1.

[0114] Experimental Example 2

[0115] Stability test

[0116] The whitening and soothing gel masks containing ferulic acid compositions prepared in Examples 1-5 were subjected to stability tests under high temperature, low temperature, thermal cycling, and light (brown bottle) conditions. The samples were kept at (45±1)℃ (high temperature) and (-15±1)℃ (low temperature) for 3 months, under alternating high and low temperature cycling conditions (24h high temperature and 24h low temperature), and under light (brown bottle) for 3 months. The gel mask material was observed for stratification, particle precipitation, discoloration, odor change, or other abnormal phenomena. The results are shown in Table 4. Examples 6-10 showed similar effects to Examples 1-5, and will not be described in detail here. Specifically, the stability results showed that no stratification, particle precipitation, or other abnormal phenomena were observed in the samples tested under high temperature, low temperature, and high and low temperature cycling conditions for 3 months. The samples were deemed to have passed the stability test if no discoloration, odor change, or other abnormal phenomena were observed after three months of continuous placement under light (with no significant difference compared to the initial state).

[0117] Table 4 Results of Sample Stability Test

[0118]

[0119] Note: √ indicates that the sample is normal.

[0120] The results in Table 4 demonstrate that ferulic acid dissolves well in the whitening and soothing gel mask containing the ferulic acid composition of this invention. This also indicates that the ferulic acid composition can be successfully applied to gel mask cosmetics, solving the problems faced by ferulic acid in practical applications.

[0121] Consumer testing and evaluation

[0122] Fourteen volunteers were selected. Each volunteer used the sample from the example and the comparative sample on both sides of their face. All volunteers used the sample from Example 1 on their left face, while the products used on their right face corresponded to those shown in Table 5. Participants used the product three times a week. After one week of use according to the instructions, a questionnaire was used to analyze the volunteers' feedback. The main dimensions of feedback collected included: permeability, post-use rinse feel, moisturizing effect, soothing effect, and whitening effect (self-assessment). Feedback was expressed on a scale of 1 to 10, with higher scores indicating greater volunteer preference and better performance, such as ease of application, good absorption, good moisturizing and soothing effects, and easy rinsing. The scoring results are shown in Table 5.

[0123] Table 5

[0124]

[0125] As shown in Table 5, due to the comparison of each volunteer's left and right faces, the sample in Example 1 received the highest score. Samples used on the right face of volunteers 1-5 had reduced levels of active ingredients, resulting in a significant weakening of efficacy, but the overall effect was still good. Samples used on the right face of volunteers 6-14 removed one or two active ingredients, thus significantly weakening the corresponding efficacy and even causing side effects. For example, the removal of hydroxyethylpiperazine ethanesulfonic acid led volunteers to believe that the sample's permeability was significantly worse, and it may have affected the skin's absorption of soothing and whitening ingredients, resulting in a decrease in both soothing and whitening effects. The scoring results of Examples 1, 4, and Comparative Example 9 show that glyceryl polyether-26, in addition to affecting the sample's moisturizing ability, also has a significant impact on the rinse feel after product use.

[0126] In vitro moisturizing test

[0127] Take a clean, dry 10mL ointment container and record the mass M0. Take 1.0g of the frozen film samples from Examples 1-3, Comparative Examples 3, and Comparative Examples 7-9 respectively into a 10mL ointment container and place it in a constant temperature and humidity chamber at RH 90% and 25℃ for 24h, and record the mass M1. Transfer the above samples to a vacuum desiccator at 25℃ and RH 20% and place them for 0.5h, 1h, 18h, and 24h respectively, and record the mass M2 accordingly. Repeat the experiment three times for each sample. The results of the sample water loss rate test are shown in Table 6. Under the same conditions, the lower the water loss rate, the better the moisturizing performance of the sample. The formula for calculating the water loss rate is as follows:

[0128] Water loss rate (%) = (M1-M2) / (M1-M0)*100%

[0129] Wherein, M0: the mass of a 10mL empty ointment box;

[0130] M1: Total mass of the ointment box and the sample to be tested after moisture absorption saturation;

[0131] M2: Total mass of the dried paste box and the sample to be tested.

[0132] Table 6 Results of Sample Water Loss Rate Test

[0133]

[0134] As shown in Table 6, the samples in Examples 1-3 had the lowest 24-hour water loss rates, with little difference between them. The only difference in composition among these three samples was approximately 5% polyol. Comparative Example 3 did not contain hydroxyethylpiperazine ethane sulfonic acid. Comparative Examples 7-9, in addition to not adding hydroxyethylpiperazine ethane sulfonic acid, also removed panthenol, SymCalmin, and ferulic acid, respectively. As is well known, hydroxyethylpiperazine ethane sulfonic acid is a biological buffer, generally used as a pH buffer in systems, and has a certain permeation-enhancing effect. The results show that sulfonic acid has a certain impact on the formulation system of the frozen membrane of this invention. After removal, the water loss rate of the sample increased significantly, indicating that the components of this invention have a synergistic effect.

[0135] Skin whitening effect experiment (Part 1)

[0136] Six volunteers were recruited to test the frozen films prepared in Examples 1, 6, and 8, and Comparative Examples 1, 3, and 9, respectively. The skin on the inner side of the left forearm was used as the test site to eliminate the influence of light on skin color; a 2cm sample was taken. 2 The skin was used as the test site. The sample was applied to the test site every night before bed for 28 days. The skin on the inner side of the right forearm was left untreated as a control. After 28 days of use, the skin color changes of both forearms of each volunteer were evaluated using the Lab colorimetric system.

[0137] The formula is: Color difference ΔE Lab =[(ΔL) 2 +(Δa) 2 +(Δb) 2 1 / 2.

[0138] In the formula, L represents brightness, ranging from black (0) to white (100), and a and b represent hue and chromaticity, respectively, representing the three-dimensional variation of chromaticity. Each person was measured three times each time, and the average value was taken. The results are shown in Table 7.

[0139] Table 7 Whitening Difference Test Results

[0140] sample Blank control 28 days later Color difference change rate (%) Example 1 62.12 65.32 4.90％ Example 6 61.87 63.85 3.10％ Example 8 61.53 63.54 3.16％ Comparative Example 1 61.94 62.87 1.48％ Comparative Example 3 62.35 63.58 1.93％ Comparative Example 9 62.06 62.64 0.93％

[0141] Table 7 shows that compared with Example 1, Example 6 reduced the content of ferulic acid, thus reducing the whitening effect. Example 8 reduced the content of hydroxyethylpiperazine ethanesulfonic acid, also reducing the whitening effect. Comparative Example 1, which did not add ferulic acid, showed an even greater difference in whitening effect, indicating that the gel mask prepared using this invention has a whitening effect. Comparative Example 9, which neither added ferulic acid nor removed hydroxyethylpiperazine ethanesulfonic acid, had the worst effect. Analysis of Examples 1, 8, Comparative Example 3, and Comparative Example 9 combined shows that hydroxyethylpiperazine ethanesulfonic acid has a synergistic effect with ferulic acid, and that hydroxyethylpiperazine ethanesulfonic acid promotes the absorption of ferulic acid by the skin.

[0142] Skin whitening effect experiment (Part 2)

[0143] Six healthy female volunteers aged 25-45 years were selected to measure the pigmentation content and skin color of their cheeks. The gel masks prepared in Examples 1, 6, and 8, and Comparative Examples 1, 3, and 9 were used. They were used once daily, applied after cleansing, left on for 15-20 minutes, and then washed off. Other whitening cosmetics were discontinued during the experiment. After 28 days of continuous use, the efficacy indicators were measured again. Before and after the trial, the skin melanin content was measured using a MEXAMETER MX18 skin pigment analyzer. Simultaneously, images were taken using the Visia facial image analyzer for later analysis of the pigmentation area ratio using Image-Pro skin comprehensive analysis software. Three consecutive tests were performed, and the average value was taken. The pigmentation area ratio and MI value are shown in Table 8.

[0144] Table 8 Results of Melanin and Pigmentation Tests

[0145]

[0146] As shown in Table 8, this experiment, by measuring melanin content and pigmentation area, yielded conclusions consistent with those of the whitening effect experiment (II) above. Therefore, it is confirmed that the frozen film prepared in this invention has a whitening effect, and that ferulic acid and hydroxyethylpiperazine ethanesulfonic acid have a certain synergistic effect.

[0147] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A whitening and soothing gel mask, characterized in that, The product comprises the following components: a water-soluble composition containing ferulic acid, panthenol, hydroxyethylpiperazine ethanesulfonic acid, glyceryl polyether-26, polyacrylate crosspolymer-6, and SymCalmin; wherein the water-soluble composition containing ferulic acid comprises the following components in parts by weight: 25-50 parts of thickening and moisturizing agent, 25-40 parts of polyol, and 0.1-1.0 parts of ferulic acid; the thickening and moisturizing agent comprises a mixture of water, glycerin, and glyceryl polyacrylate; the mass ratio of water, glycerin, and glyceryl polyacrylate in the thickening and moisturizing agent is 4-5:4-5:0.5; The polyol includes at least one of glycerol, butanediol, and 1,3-propanediol.

2. The whitening and soothing gel mask according to claim 1, characterized in that, The method for preparing the water-soluble composition containing ferulic acid includes the following steps: The thickening and moisturizing agent, polyol, and ferulic acid are mixed in the specified proportions to obtain the final product.

3. The whitening and soothing gel mask according to claim 1, characterized in that, It comprises the following components in parts by weight: 11-50 parts of a water-soluble composition containing ferulic acid, 0.1-0.5 parts of panthenol, 0.1-0.5 parts of hydroxyethylpiperazine ethane sulfonic acid, 0.5-3 parts of glycerol polyether-26, 0.01-1.0 parts of polyacrylate crosspolymer-6, and 0.2-0.3 parts of SymCalmin.

4. A method for preparing the whitening and soothing gel mask according to any one of claims 1 to 3, comprising the following steps: Mix the water-soluble composition containing ferulic acid, panthenol, hydroxyethylpiperazine ethane sulfonic acid, and polyacrylate crosspolymer-6 in proportion, heat and stir at 80 ℃~90 ℃, cool to 35 ℃~45 ℃, add glycerol polyether-26 and SymCalmin, stir, and the mixture is ready.

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