A multi-purpose medical dressing based on triatomic oxidized oil and its preparation method

Abstract

The invention discloses a multipurpose medical dressing based on triatomic oxidized oil and a preparation method thereof. The multipurpose medical dressing comprises the following raw materials in parts by weight: 160-170 parts of triatomic oxidized oil, 30-40 parts of modified thickener and 2-7 parts of penetrant; the modified penetrant has a good bactericidal effect, and the side chain contains a long-chain quaternary ammonium salt structure and the long-chain quaternary ammonium salt is a spirocyclic structure, so that in the process of the quaternary ammonium salt inserting into the bacterial cell membrane, the perforated gap of the cell membrane is expanded, and then the cells are caused to flow out. The medical dressing has a killing effect on pathogenic microorganisms, can reduce inflammation and relieve pain, and promote wound healing. It has obvious therapeutic effects on joint pain and intractable skin diseases. It is a non-toxic product and has no irritation to skin, mucous membranes, eyes, etc. at low concentrations. Due to the small molecular weight of O3, it has a strong permeation effect on cells and tissues, and can penetrate into the 2mm below the mucosa to kill the pathogenic microorganisms in the cells and tissues.

Description

Technical Field

[0001] The present invention relates to the technical field of medical dressing preparation, and in particular to a multi-purpose medical dressing based on tri-atom oxidized oil and a preparation method thereof. Background Art

[0002] Triatomic oxygen gas is chemically unstable and easily decomposes into oxygen, limiting its clinical application, such as in home treatments. Therefore, appropriate storage methods for ozone therapy can not only facilitate clinical use and expand its indications, but also increase compliance with ozone therapy and enhance its effectiveness. Studies have shown that ozone treatment of vegetable oils forms an "ozone reservoir" that converts ozone into unsaturated fatty acid trioxides, preserving the stored ozone before slowly releasing it to the therapeutic target. Ozone oil, also known as ozonated oil, is a versatile bactericidal agent, boasting a sterilizing effect 600 times greater than that of antibiotics, 3,000 times greater than that of ultraviolet light, and tens of thousands times greater than that of traditional Chinese medicine. Ozone has a broad-spectrum bactericidal effect against a wide range of pathogenic microorganisms, including bacteria, fungi, viruses, and molds. It also enhances local blood circulation, making it suitable for a variety of conditions, including joint pain, burns, skin diseases, onychomycosis, chronic ulcers, diabetic foot, acute and chronic infections of the skin and mucous membranes, skin allergies, surgical wound healing, insect bites, gingivitis, oral ulcers, and vaginitis. Summary of the Invention

[0003] The purpose of the present invention is to provide a multi-purpose medical dressing based on triatomic oxidized oil and a preparation method thereof, which solves the problem that the current medical dressing has a slow effect on wound healing and has an infection risk.

[0004] The purpose of the present invention can be achieved through the following technical solutions:

[0005] A method for preparing a multi-purpose medical dressing based on triatomic oxidized oil specifically comprises the following steps:

[0006] The following raw materials are weighed in parts by weight: 160-170 parts of triatom oxidized oil, 30-40 parts of modified thickener and 2-7 parts of penetrant, and the triatom oxidized oil, modified thickener and penetrant are uniformly mixed to prepare a multi-purpose medical dressing.

[0007] Furthermore, the penetrant is one of laurocapram and dimethyl sulfoxide or a mixture of the two in any proportion.

[0008] Furthermore, the modified thickener is prepared by the following steps:

[0009] Step A1: chitosan, acetic acid solution and methanol are mixed, stirred at a speed of 200-300 r / min and a temperature of 20-25° C. for 3-5 hours, heated to 65-70° C., maleic anhydride and pyridine are added, and the reaction is carried out for 10-15 hours to obtain carboxylated chitosan. The pretreated chitosan is dissolved in DMF, diallylamine and N,N-dicyclohexylcarbodiimide are added, stirred at a speed of 150-200 r / min and a temperature of 25-30° C. for 6-8 hours, and then distilled under reduced pressure to obtain pretreated chitosan.

[0010] Step A2: pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol are uniformly mixed, stirred and ammonium persulfate is added at a speed of 150-200 r / min, a temperature of 25-30° C. and a pH value of 5-5.5, and the mixture is reacted for 10-15 minutes to obtain a modified thickener.

[0011] Furthermore, the amount ratio of chitosan, acetic acid solution, methanol, maleic anhydride and pyridine described in step A1 is 1 g:50 mL:50 mL:3 g:1 mL, the mass fraction of acetic acid solution is 80%, and the molar ratio of carboxyl, diallylamine and N,N-dicyclohexylcarbodiimide on the pretreated chitosan is 1:1:3.

[0012] Furthermore, the amount ratio of the pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol described in step A2 is 1g:2.5g:25g:15g:10g:20mL, and the amount of potassium persulfate is 0.3-0.5% of the total mass of the modified monomer, acrylamide, octadecyl acrylate and acrylic acid.

[0013] Furthermore, the modified monomer is prepared by the following steps:

[0014] Step B1: 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid, and toluene are mixed and stirred at 150-200 r / min and 120-125°C for 5-7 hours to obtain intermediate 1. Intermediate 1, terephthalic acid, 4-dimethylaminopyridine, and dichloromethane are uniformly mixed and purged with argon. N,N-dicyclohexylcarbodiimide is added at -5°C, the temperature is raised to 20-25°C, and the reaction is carried out for 25-30 hours to obtain intermediate 2.

[0015] Step B2: Intermediate 2, N,N-dimethylethanolamine, p-toluenesulfonic acid and DMF are mixed uniformly, and the mixture is reacted at a speed of 150-200 r / min and a temperature of 110-120°C for 5-7 hours to obtain intermediate 3. Acryloyl chloride, intermediate 3, potassium carbonate and DMF are mixed, and stirred at a speed of 200-300 r / min and a temperature of 20-25°C for 1-1.5 hours. Potassium iodide is added, and stirring is continued for 15-20 hours. The mixture is concentrated under reduced pressure to obtain a modified monomer.

[0016] Furthermore, the amount ratio of 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene in step B1 is 5.2 mmol:2.6 mmol:0.1 mmol:25 mL, and the molar ratio of intermediate 1, terephthalic acid, 4-dimethylaminopyridine and N,N-dicyclohexylcarbodiimide is 1:1:2:5-6.

[0017] Furthermore, the molar ratio of intermediate 2 and N,N-dimethylethanolamine described in step B2 is 1:1, the amount of p-toluenesulfonic acid is 3-5% of the total mass of intermediate 2 and N,N-dimethylethanolamine, and the molar ratio of acryloyl chloride, intermediate 3, potassium carbonate and potassium iodide is 1:1:1.2:1.1.

[0018] The beneficial effects of the present invention are as follows: a multi-purpose medical dressing based on triatomic oxidized oil prepared by the present invention is prepared from the following raw materials: triatomic oxidized oil, modified thickener and penetrant, wherein the modified thickener is treated with chitosan as raw material with maleic anhydride to prepare carboxylated chitosan, the carboxylated chitosan is reacted with diallylamine, so that the carboxyl group on the carboxylated chitosan and the secondary amine on the diallylamine are dehydrated and condensed to prepare pretreated chitosan, the pretreated chitosan, modified monomer, acrylamide, acrylic acid octadecene are reacted with the pretreated chitosan, and the modified monomer, acrylamide, acrylic acid octadecene are reacted with the pretreated chitosan. Ester and acrylic acid are polymerized to obtain a modified thickener. The modified monomer uses 4-hydroxybenzoic acid and pentaerythritol as raw materials to undergo a diacetal reaction to obtain intermediate 1. Intermediate 1 is reacted with terephthalic acid to dehydrate and condense the hydroxyl group on intermediate 1 with the carboxyl group on terephthalic acid to obtain intermediate 2. Intermediate 2 is esterified with N,N-dimethylethanolamine to obtain intermediate 3. Intermediate 3 is reacted with phenolic hydroxyl group on intermediate 3 under the action of potassium carbonate, and iodine is added. Potassium chloride forms a quaternary ammonium salt structure to prepare a modified monomer. The modified penetrant has a good bactericidal effect. The side chain contains a long-chain quaternary ammonium salt structure and the long-chain quaternary ammonium salt is a spirocyclic structure. When the quaternary ammonium salt is inserted into the bacterial cell membrane, the opening gap of the cell membrane is expanded, thereby causing the cell to flow out and achieve the effect of killing the cells. The medical dressing has a killing effect on most pathogenic microorganisms such as bacteria, viruses, fungi, molds, mycoplasmas, chlamydia, and Trichomonas vaginalis. It is a non-toxic product and has no irritation to the skin, mucous membranes, eyes, etc. at low concentrations. Due to the small molecular weight of O3, it has a strong penetrating effect on cells and tissues, and can penetrate 2mm below the mucosa to kill pathogenic microorganisms in cells and tissues. Unlike common antibiotics, anti-inflammatory and antiviral drugs, this dressing will not make viruses resistant, and has dual bactericidal and therapeutic functions. After killing pathogenic microorganisms, oxygen is generated, which can be absorbed and utilized by cells and tissues, accelerate local tissue blood circulation, and promote wound healing. Implementation Method

[0019] The following is a clear and complete description of the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only some embodiments of the present invention, not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making any creative efforts are within the scope of protection of the present invention. Example

[0020] A method for preparing a multi-purpose medical dressing based on triatomic oxidized oil specifically comprises the following steps:

[0021] Weigh the following raw materials in parts by weight: 160 parts of triatom oxidized oil, 30 parts of modified thickener and 2 parts of lauryl azone, and mix the triatom oxidized oil, modified thickener and lauryl azone evenly to prepare a multi-purpose medical dressing.

[0022] The modified thickener is prepared by the following steps:

[0023] Step A1: chitosan, acetic acid solution and methanol were mixed, stirred at a speed of 200 r / min and a temperature of 20° C. for 3 h, heated to 65° C., maleic anhydride and pyridine were added, and the reaction was carried out for 10 h to obtain carboxylated chitosan. The pretreated chitosan was dissolved in DMF, diallylamine and N,N-dicyclohexylcarbodiimide were added, stirred at a speed of 150 r / min and a temperature of 25° C. for 6 h, and then distilled under reduced pressure to obtain pretreated chitosan.

[0024] Step A2: pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol were mixed uniformly, stirred at a speed of 150 r / min, a temperature of 25° C. and a pH value of 5, and ammonium persulfate was added and reacted for 10 minutes to prepare a modified thickener.

[0025] The amount ratio of chitosan, acetic acid solution, methanol, maleic anhydride and pyridine described in step A1 is 1g:50mL:50mL:3g:1mL, the mass fraction of acetic acid solution is 80%, and the molar ratio of carboxyl group, diallylamine and N,N-dicyclohexylcarbodiimide on the pretreated chitosan is 1:1:3.

[0026] The amount ratio of the pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol described in step A2 is 1g:2.5g:25g:15g:10g:20mL, and the amount of potassium persulfate is 0.3% of the total mass of the modified monomer, acrylamide, octadecyl acrylate and acrylic acid.

[0027] The modified monomer is prepared by the following steps:

[0028] Step B1: 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene were mixed and stirred at 150 r / min and 120°C for 5 h to obtain intermediate 1. Intermediate 1, terephthalic acid, 4-dimethylaminopyridine and dichloromethane were mixed uniformly, and argon was introduced into the mixture. N,N-dicyclohexylcarbodiimide was added at -5°C, the temperature was raised to 20°C, and the reaction was carried out for 25 h to obtain intermediate 2.

[0029] Step B2: Intermediate 2, N,N-dimethylethanolamine, p-toluenesulfonic acid and DMF were mixed uniformly, and the reaction was carried out at a speed of 150 r / min and a temperature of 110°C for 5 hours to obtain intermediate 3. Acryloyl chloride, intermediate 3, potassium carbonate and DMF were mixed, and stirred at a speed of 200 r / min and a temperature of 20°C for 1 hour. Potassium iodide was added, and stirring was continued for 15 hours. The mixture was concentrated under reduced pressure to obtain a modified monomer.

[0030] The amount ratio of 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene in step B1 is 5.2 mmol:2.6 mmol:0.1 mmol:25 mL, and the molar ratio of intermediate 1, terephthalic acid, 4-dimethylaminopyridine and N,N-dicyclohexylcarbodiimide is 1:1:2:5.

[0031] The molar ratio of intermediate 2 and N,N-dimethylethanolamine described in step B2 is 1:1, the amount of p-toluenesulfonic acid is 3% of the total mass of intermediate 2 and N,N-dimethylethanolamine, and the molar ratio of acryloyl chloride, intermediate 3, potassium carbonate and potassium iodide is 1:1:1.2:1.1. Example

[0032] A method for preparing a multi-purpose medical dressing based on triatomic oxidized oil specifically comprises the following steps:

[0033] Weigh the following raw materials in parts by weight: 165 parts of triatomic oxidized oil, 35 parts of modified thickener and 5 parts of lauryl azone, and mix the triatomic oxidized oil, modified thickener and lauryl azone evenly to prepare a multi-purpose medical dressing.

[0034] The modified thickener is prepared by the following steps:

[0035] Step A1: chitosan, acetic acid solution and methanol are mixed, stirred at a speed of 200 r / min and a temperature of 23° C. for 4 hours, heated to 68° C., maleic anhydride and pyridine are added, and the reaction is carried out for 10-15 hours to obtain carboxylated chitosan. The pretreated chitosan is dissolved in DMF, diallylamine and N,N-dicyclohexylcarbodiimide are added, stirred at a speed of 200 r / min and a temperature of 28° C. for 7 hours, and then distilled under reduced pressure to obtain pretreated chitosan;

[0036] Step A2: pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol were mixed uniformly, stirred at a speed of 150 r / min, a temperature of 30° C. and a pH value of 5, and ammonium persulfate was added and reacted for 13 minutes to prepare a modified thickener.

[0037] The amount ratio of chitosan, acetic acid solution, methanol, maleic anhydride and pyridine described in step A1 is 1g:50mL:50mL:3g:1mL, the mass fraction of acetic acid solution is 80%, and the molar ratio of carboxyl group, diallylamine and N,N-dicyclohexylcarbodiimide on the pretreated chitosan is 1:1:3.

[0038] The amount ratio of the pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol described in step A2 is 1g:2.5g:25g:15g:10g:20mL, and the amount of potassium persulfate is 0.4% of the total mass of the modified monomer, acrylamide, octadecyl acrylate and acrylic acid.

[0039] The modified monomer is prepared by the following steps:

[0040] Step B1: 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid, and toluene were mixed and stirred at 150 r / min and 123°C for 6 h to obtain intermediate 1. Intermediate 1, terephthalic acid, 4-dimethylaminopyridine, and dichloromethane were uniformly mixed and purged with argon. N,N-dicyclohexylcarbodiimide was added at -5°C, and the temperature was raised to 23°C. The reaction was carried out for 28 h to obtain intermediate 2.

[0041] Step B2: Intermediate 2, N,N-dimethylethanolamine, p-toluenesulfonic acid and DMF were mixed uniformly, and the reaction was carried out at a speed of 150 r / min and a temperature of 115°C for 6 hours to obtain intermediate 3. Acryloyl chloride, intermediate 3, potassium carbonate and DMF were mixed, and stirred at a speed of 200 r / min and a temperature of 23°C for 1.3 hours. Potassium iodide was added, and stirring was continued for 18 hours. The mixture was concentrated under reduced pressure to obtain a modified monomer.

[0042] The amount ratio of 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene in step B1 is 5.2 mmol:2.6 mmol:0.1 mmol:25 mL, and the molar ratio of intermediate 1, terephthalic acid, 4-dimethylaminopyridine and N,N-dicyclohexylcarbodiimide is 1:1:2:6.

[0043] The molar ratio of intermediate 2 and N,N-dimethylethanolamine described in step B2 is 1:1, the amount of p-toluenesulfonic acid is 4% of the sum of the mass of intermediate 2 and N,N-dimethylethanolamine, and the molar ratio of acryloyl chloride, intermediate 3, potassium carbonate and potassium iodide is 1:1:1.2:1.1. Example

[0044] A method for preparing a multi-purpose medical dressing based on triatomic oxidized oil specifically comprises the following steps:

[0045] Weigh the following raw materials in parts by weight: 170 parts of triatomic oxidized oil, 40 parts of modified thickener and 7 parts of dimethyl sulfoxide, and mix the triatomic oxidized oil, modified thickener and dimethyl sulfoxide evenly to prepare a multi-purpose medical dressing.

[0046] The modified thickener is prepared by the following steps:

[0047] Step A1: chitosan, acetic acid solution and methanol were mixed, stirred at a speed of 300 r / min and a temperature of 25°C for 5 hours, heated to 70°C, maleic anhydride and pyridine were added, and the reaction was carried out for 15 hours to obtain carboxylated chitosan. The pretreated chitosan was dissolved in DMF, diallylamine and N,N-dicyclohexylcarbodiimide were added, stirred at a speed of 200 r / min and a temperature of 30°C for 8 hours, and then distilled under reduced pressure to obtain pretreated chitosan.

[0048] Step A2: pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol were mixed uniformly, stirred and ammonium persulfate was added at a speed of 200 r / min, a temperature of 30° C. and a pH value of 5.5, and reacted for 15 minutes to obtain a modified thickener.

[0049] The amount ratio of chitosan, acetic acid solution, methanol, maleic anhydride and pyridine described in step A1 is 1g:50mL:50mL:3g:1mL, the mass fraction of acetic acid solution is 80%, and the molar ratio of carboxyl group, diallylamine and N,N-dicyclohexylcarbodiimide on the pretreated chitosan is 1:1:3.

[0050] The amount ratio of the pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol described in step A2 is 1g:2.5g:25g:15g:10g:20mL, and the amount of potassium persulfate is 0.5% of the total mass of the modified monomer, acrylamide, octadecyl acrylate and acrylic acid.

[0051] The modified monomer is prepared by the following steps:

[0052] Step B1: 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene were mixed and stirred at 200 r / min and 125°C for 7 hours to obtain intermediate 1. Intermediate 1, terephthalic acid, 4-dimethylaminopyridine and dichloromethane were mixed uniformly, and argon was introduced into the mixture. N,N-dicyclohexylcarbodiimide was added at -5°C, the temperature was raised to 25°C, and the reaction was carried out for 30 hours to obtain intermediate 2.

[0053] Step B2: Intermediate 2, N,N-dimethylethanolamine, p-toluenesulfonic acid and DMF were mixed uniformly, and the reaction was carried out at a speed of 200 r / min and a temperature of 120°C for 7 hours to obtain intermediate 3. Acryloyl chloride, intermediate 3, potassium carbonate and DMF were mixed, and stirred at a speed of 300 r / min and a temperature of 25°C for 1.5 hours. Potassium iodide was added, and stirring was continued for 20 hours. The mixture was concentrated under reduced pressure to obtain a modified monomer.

[0054] The amount ratio of 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene in step B1 is 5.2 mmol:2.6 mmol:0.1 mmol:25 mL, and the molar ratio of intermediate 1, terephthalic acid, 4-dimethylaminopyridine and N,N-dicyclohexylcarbodiimide is 1:1:2:6.

[0055] The molar ratio of intermediate 2 and N,N-dimethylethanolamine described in step B2 is 1:1, the amount of p-toluenesulfonic acid is 5% of the sum of the mass of intermediate 2 and N,N-dimethylethanolamine, and the molar ratio of acryloyl chloride, intermediate 3, potassium carbonate and potassium iodide is 1:1:1.2:1.1.

[0056] Comparative Example 1

[0057] Compared with Example 1, this comparative example did not add the modified monomer, and the remaining steps were the same.

[0058] Comparative Example 2

[0059] Compared with Example 1, in this comparative example, acryloyl chloride, N,N-dimethylethanolamine, potassium carbonate and DMF were mixed, stirred at a speed of 200 r / min and a temperature of 20°C for 1 hour, potassium iodide was added, and stirring was continued for 15 hours. The mixture was concentrated under reduced pressure to obtain a product instead of the modified monomer, and the remaining steps were the same.

[0060] Female rats were divided into a dressing group and a blank control group. The wounds of the dressing group were covered with a multi-purpose medical dressing, while the control group received no treatment. There were 3 rats in each group. The rats were depilated under anesthesia, and a full-thickness wound with a diameter of 10 mm was incised on the back of each rat. The dressings of the experimental group were changed on the 3rd and 7th days. The rats were observed on the 3rd, 7th, and 14th days. The skin tissue samples were fixed with formalin, and the pathological sections were stained with hematoxylin-eosin.

[0061] The antibacterial adhesion activity of the hydrogel was tested in vitro using common Gram-positive and Gram-negative bacteria. A multipurpose medical dressing was prepared into cylinders with a diameter of 1.0 cm and a thickness of 0.2 cm as the experimental group, while a control group was medical gauze. A bacterial suspension concentration of 108 (CFU / mL) was used. 50 μL of the bacterial suspension was dripped onto the hydrogel and gauze surfaces, respectively. After incubation with shaking for 4 hours, the hydrogels were gently washed twice with 1 mL of sterile saline. The hydrogels and control groups were then mixed with 1 mL of sterile saline and sonicated for 20 minutes. Afterward, 100 μL of the sonicated solution was evenly spread on agar medium and incubated at 37°C for 18 hours. Scanning electron microscopy images of the two 48-hour freeze-dried groups were taken to observe adherent bacterial cells and count the number of bacteria.

[0062] 600 patients with joint pain and swelling caused by various types of arthritis were randomly divided into 5 groups, with 120 cases in each group. There was no statistical difference in age, gender, course of disease, cause, or degree of joint pain among the groups. The multipurpose medical dressings prepared in Examples 1-3 and Comparative Examples 1-2 were applied twice a day for five days as a course of treatment. The patients were judged as cured if the joint pain disappeared or almost disappeared, the joint movement returned to normal, and there was no joint swelling. Effective if the joint pain improved, the joint movement was slightly restricted, and there was mild joint swelling. Ineffective if the joint pain did not improve significantly or even worsened, the joint movement was restricted, the movement was difficult, and there was severe joint swelling. The cure rate was calculated.

[0063] 180 patients with tinea corporis and cruris were randomly divided into groups, with 36 patients in each group. The treatment method was as follows: the multi-purpose medical dressings prepared in Examples 1-3 and Comparative Examples 1-2 were applied to the tinea corporis and cruris, and the dressings were changed twice a day. Any other treatments were stopped during the treatment period. The efficacy was observed after 5 days. The efficacy judgment criteria were: cured: the tinea corporis and cruris completely disappeared; effective: the area of ​​tinea corporis and cruris was reduced and there was no itching; ineffective: the symptoms did not change significantly after medication compared with before treatment. The test results are shown in the following table.

[0064]

[0065] It can be seen from the above table that the present application has good effects of wound healing, anti-inflammatory and analgesic, and treating skin diseases.

[0066] The above content is merely an example and explanation of the concept of the present invention. Those skilled in the art may make various modifications or additions to the described specific embodiments or replace them in a similar manner. As long as they do not deviate from the concept of the invention or exceed the scope defined by the claims, they should all fall within the scope of protection of the present invention.

Claims

1. A method for preparing a multi-purpose medical dressing based on triatomic oxidized oil, characterized in that: The specific steps include: Weigh the following raw materials in parts by weight: 160-170 parts of triatomic oxidized oil, 30-40 parts of modified thickener, and 2-7 parts of penetrant, and evenly mix the triatomic oxidized oil, modified thickener, and penetrant to prepare a multi-purpose medical dressing; The modified thickener is prepared by the following steps: Step A1: Chitosan, acetic acid solution, and methanol are mixed and stirred, heated, and maleic anhydride and pyridine are added to react to obtain carboxylated chitosan. The carboxylated chitosan is dissolved in DMF, diallylamine and N,N-dicyclohexylcarbodiimide are added, stirred, and then distilled under reduced pressure to obtain pretreated chitosan. Step A2: mixing the pretreated chitosan, the modified monomer, acrylamide, octadecyl acrylate, acrylic acid, and glycerol, adding ammonium persulfate, and reacting to prepare a modified thickener; The chitosan, acetic acid solution, methanol, maleic anhydride, and pyridine described in step A1 are used in a ratio of 1 g:50 mL:50 mL:3 g:1 mL, and the molar ratio of the carboxyl group on the carboxylated chitosan, diallylamine, and N,N-dicyclohexylcarbodiimide is 1:1:3; The amount ratio of the pretreated chitosan, modified monomer, acrylamide, octadecyl acrylate, acrylic acid and glycerol described in step A2 is 1g:2.5g:25g:15g:10g:20mL; The modified monomer is prepared by the following steps: Step B1: 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene were mixed and stirred under reflux to obtain intermediate 1. Intermediate 1, terephthalic acid, 4-dimethylaminopyridine and dichloromethane were mixed evenly, and argon was passed through. N,N-dicyclohexylcarbodiimide was added and reacted to obtain intermediate 2; Step B2: Intermediate 2, N,N-dimethylethanolamine, p-toluenesulfonic acid, and DMF are mixed to react to obtain Intermediate 3. Acryloyl chloride, Intermediate 3, potassium carbonate, and DMF are mixed and stirred, followed by the addition of potassium iodide. The mixture is stirred continuously and concentrated under reduced pressure to obtain a modified monomer. The amount ratio of 4-hydroxybenzaldehyde, pentaerythritol, p-toluenesulfonic acid and toluene in step B1 is 5.2 mmol:2.6 mmol:0.1 mmol:25 mL, and the molar ratio of intermediate 1, terephthalic acid, 4-dimethylaminopyridine and N,N-dicyclohexylcarbodiimide is 1:1:2:5-6; The molar ratio of intermediate 2 and N,N-dimethylethanolamine in step B2 is 1:1, and the molar ratio of acryloyl chloride, intermediate 3, potassium carbonate and potassium iodide is 1:1:1.2:1.

1.

2. The method for preparing a multi-purpose medical dressing based on triatomic oxidized oil according to claim 1, characterized in that: The penetrant is one of laurocapram and dimethyl sulfoxide or a mixture of the two in any proportion.

3. The method for preparing a multi-purpose medical dressing based on triatomic oxidized oil according to claim 1, characterized in that: The mass fraction of the acetic acid solution described in step A1 is 80%.

4. The method for preparing a multi-purpose medical dressing based on triatomic oxidized oil according to claim 1, characterized in that: The amount of p-toluenesulfonic acid used in step B2 is 3-5% of the total mass of intermediate 2 and N,N-dimethylethanolamine.

5. A multi-purpose medical dressing based on triatomic oxidized oil, characterized by: Prepared according to any one of the preparation methods described in claims 1-4.

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