A Chinese medicine composition for treating semen abnormality and sexual dysfunction and preparation method thereof

Abstract

The invention discloses a Chinese medicine composition and preparation method for treating abnormal semen and sexual dysfunction, belonging to the technical field of Chinese medicine formula, the Chinese medicine composition is mainly made of the following raw materials in parts by weight: 5-100 parts of turtle shell, 5-50 parts of honeysuckle, 5-50 parts of salvia miltiorrhiza, 5-50 parts of Rehmannia glutinosa, 1-30 parts of coptis root, 5-50 parts of Scrophularia ningpoensis, 5-90 parts of litchi seed, 5-50 parts of kudzu root, 5-50 parts of angelica, 5-100 parts of raw astragalus, 5-50 parts of epimedium, 5-50 parts of wolfberry, 2-50 parts of liquorice Chinese medicine composition, compared with the prior art, the Chinese medicine composition of the present invention is used to treat reproductive health problems such as abnormal sperm and semen and sexual dysfunction caused by diabetes, with good efficacy, no side effects and other characteristics. Its preparation method is simple, fast, efficient and easy to operate. The prepared mixture, granules, etc. are easy to carry and convenient to take. In addition, the Chinese medicine composition of the present invention can completely cure the above-mentioned diseases, without the need for long-term medication, and can effectively prevent the recurrence of the disease.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine formulations, and particularly relates to a traditional Chinese medicine composition for treating sperm and semen abnormalities and sexual dysfunction caused by diabetes and a preparation method thereof. Background Art

[0002] Diabetes mellitus (DM) is one of the most prominent public health threats in modern society, and the number of reproductive-aged and adolescent males is increasing. An important complication of diabetes is disorders of the male reproductive system. In diabetic patients, long-term hyperglycemia can lead to diabetic angioneuropathy, oxidative stress injury, abnormal zinc metabolism, and insulin resistance syndrome. In addition, insulin deficiency and resistance in diabetic patients can damage the hypothalamus, pituitary gland, gonads, and around the gonads. This can reduce the secretion of sex hormones, including gonadotropin-releasing hormone, follicle-stimulating hormone, luteinizing hormone, and testosterone, and can cause testicular atrophy, stromal cell atrophy, damage to seminiferous tubules, damage to spermatogenic cells, erectile dysfunction, ejaculatory and other reproductive organ structural changes and abnormal semen quality, all of which can affect male fertility and reproductive health. Research shows that nearly half of male diabetic patients have decreased semen quality and impaired reproductive function. Compared with other countries, the incidence of DM in China is higher. The number of male diabetic patients is gradually increasing, and the fertility problems of the male population are also gradually increasing. Therefore, male reproductive health problems are attracting more and more attention.

[0003] Treating male reproductive dysfunction related to DM is a challenge, and the main treatment is still mainly to lower blood sugar. In recent years, efforts have been made to study treatment methods for improving and treating reproductive health abnormalities such as diabetic erectile dysfunction (DMED). Traditional Chinese medicine and modern medicine have their respective advantages and disadvantages in treating male reproductive health problems caused by diabetes. Therefore, combining the advantages of both and breaking through the bottleneck of diabetes treatment, exploring new measures for preventing and coping with erectile dysfunction caused by diabetes from the perspective of the combination of traditional Chinese medicine and modern medicine will be worth trying. Summary of the Invention

[0004] Aiming at the deficiencies of the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating semen abnormalities and sexual dysfunction and a preparation method thereof.

[0005] The purpose of the present invention can be achieved by the following technical solutions:

[0006] A traditional Chinese medicine composition, comprising the following components in parts by weight: 5 - 100 parts of turtle shell, 5 - 50 parts of honeysuckle flower, 5 - 50 parts of salvia miltiorrhiza, 5 - 50 parts of prepared rehmannia root, 1 - 30 parts of coptis chinensis, 5 - 50 parts of scrophularia root, 5 - 90 parts of litchi seed, 5 - 50 parts of kudzu root, 5 - 50 parts of angelica sinensis, 5 - 100 parts of astragalus membranaceus, 5 - 50 parts of epimedium, 5 - 50 parts of wolfberry fruit, and 2 - 50 parts of liquorice.

[0007] Preferably, each component specifically consists of the following components in parts by weight: 20 parts of turtle shell, 10 parts of honeysuckle flower, 10 parts of salvia miltiorrhiza, 10 parts of prepared rehmannia root, 3 parts of coptis root, 10 parts of scrophularia root, 30 parts of litchi seed, 10 parts of kudzu root, 10 parts of angelica sinensis, 20 parts of astragalus membranaceus, 10 parts of epimedium herb, 10 parts of wolfberry fruit, and 5 parts of liquorice root.

[0008] A preparation method of a traditional Chinese medicine composition comprises the following steps: weighing the formulated drugs, wherein the formulated drugs include: 5 - 100 parts of turtle shell, 5 - 50 parts of honeysuckle flower, 5 - 50 parts of salvia miltiorrhiza, 5 - 50 parts of prepared rehmannia root, 1 - 30 parts of coptis root, 5 - 50 parts of scrophularia root, 5 - 90 parts of litchi seed, 5 - 50 parts of kudzu root, 5 - 50 parts of angelica sinensis, 5 - 100 parts of astragalus membranaceus, 5 - 50 parts of epimedium herb, 5 - 50 parts of wolfberry fruit, and 2 - 50 parts of liquorice root. Add water with a weight 5 - 15 times that of the total weight of the formulated drugs, soak and then decoct, filter after decocting, combine the filtrates, and then prepare into a liquid preparation or a solid preparation to obtain the traditional Chinese medicine composition.

[0009] Preferably, the method for preparing the liquid preparation is: concentrating the filtrate under reduced pressure, centrifuging with a high - speed centrifuge, adding water again, subpackaging, and sterilizing.

[0010] Preferably, the specific operation of concentrating the filtrate under reduced pressure is: concentrating the filtrate under reduced pressure to an extract with a relative density of 1.00 - 1.20, adding ethanol until the alcohol content is 45% - 70%, standing for 24 hours, taking the supernatant, recovering ethanol and continuing to concentrate to a thick paste with a relative density of 1.15 - 1.35, adding pharmaceutical excipients and mixing, and then preparing into a granule, powder, tablet, pill, mixture or capsule.

[0011] Preferably, the decocting is specifically: decocting 1 - 3 times, each time for 1 - 2 h.

[0012] A pharmaceutical preparation, which comprises the above - mentioned traditional Chinese medicine composition and a pharmaceutically acceptable carrier.

[0013] Preferably, the pharmaceutical preparation is a granule, powder, tablet, pill, mixture or capsule.

[0014] The application of the preparation method in the preparation of a pharmaceutical preparation.

[0015] The beneficial effects of the present invention:

[0016] The traditional Chinese medicine compound drug of the present invention has been clinically verified for many years and has the effects of nourishing yin and clearing heat, regulating qi and activating blood circulation. Indications: male reproductive complications caused by diabetes, including oligospermia, asthenospermia, abnormal semen and sexual dysfunction;

[0017] The traditional Chinese medicine composition Simiao Biejia (SMBJ) Decoction of the present invention is an empirical formula summarized based on clinical experience. It is composed of the modified Simum Yong'an Decoction and Erdi Biejia Decoction, and has the effects of "nourishing yin and tonifying the kidney, clearing heat and promoting blood circulation". It is composed of 13 traditional Chinese medicines including turtle shell, wolfberry fruit, honeysuckle flower, salvia miltiorrhiza, prepared rehmannia root, coptis chinensis, scrophularia root, litchi seed, kudzu root, angelica sinensis, astragalus membranaceus, epimedium, and licorice. This prescription has remarkable effects on reproductive system diseases such as oligospermia, asthenospermia, and sexual dysfunction caused by diabetes in clinical treatment. Among them, turtle shell nourishes yin and subdues yang, and wolfberry fruit nourishes the liver and kidney. The two together play the role of nourishing yin and tonifying the kidney, and are the monarch drugs. Honeysuckle flower and scrophularia root clear heat and nourish yin, salvia miltiorrhiza promotes blood circulation and nourishes blood, prepared rehmannia root tonifies the kidney and nourishes blood and yin, and epimedium warms and tonifies the liver and kidney to prevent the cold of heat-clearing drugs from damaging yang. The five together clear and tonify essence and blood, and are the minister drugs. Litchi seed promotes qi circulation and dissipates stagnation, kudzu root promotes the production of body fluid and quenches thirst, and coptis chinensis clears heat and detoxifies. Modern pharmacological research shows that the above three all have the effect of reducing blood sugar. Astragalus membranaceus and angelica sinensis supplement qi and nourish blood. The five together clear heat and nourish blood, and are the assistant drugs. Licorice invigorates the spleen and replenishes qi, and harmonizes various drugs, and is the guiding drug. The whole prescription together plays the effects of nourishing yin and tonifying the kidney, clearing heat and promoting blood circulation.

[0018] Technical effects: Compared with the prior art, the traditional Chinese medicine composition of the present invention is used to treat sperm and semen abnormalities and sexual dysfunction caused by diabetes, and has the characteristics of good curative effect and no side effects. Its preparation method is simple, rapid, efficient, and easy to operate. The prepared mixture, granules, etc. are convenient to carry and take. In addition, the traditional Chinese medicine composition of the present invention can completely cure the above diseases, does not require long-term medication, and can effectively prevent the recurrence of diseases. Specific embodiments

[0019] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without making creative efforts belong to the scope of protection of the present invention.

[0020] A traditional Chinese medicine composition for treating semen abnormalities and sexual dysfunction, comprising the following components in parts by weight: 5-100 parts of turtle shell, 5-50 parts of honeysuckle flower, 5-50 parts of salvia miltiorrhiza, 5-50 parts of prepared rehmannia root, 1-30 parts of coptis chinensis, 5-50 parts of scrophularia root, 5-90 parts of litchi seed, 5-50 parts of kudzu root, 5-50 parts of angelica sinensis, 5-100 parts of astragalus membranaceus, 5-50 parts of epimedium, 5-50 parts of wolfberry fruit, and 2-50 parts of licorice.

[0021] The specific preparation method is as follows:

[0022] Example 1

[0023] Formulation:

[0024] 5 parts of turtle shell, 5 parts of honeysuckle flower, 20 parts of salvia root, 50 parts of prepared rehmannia root, 20 parts of coptis root, 10 parts of scrophularia root, 50 parts of litchi seed, 10 parts of kudzu root, 10 parts of angelica root, 50 parts of astragalus root, 5 parts of epimedium herb, 10 parts of wolfberry fruit, 5 parts of liquorice root.

[0025] Preparation method:

[0026] Add water with a weight 5 times that of the total weight of the formula drugs, soak for 60 minutes, decoct 3 times, 1 hour each time, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an appropriate amount, centrifuge with a high-speed centrifuge, add water to the specified amount, subpackage, sterilize to obtain a liquid drug, thus obtained.

[0027] Example 2

[0028] Formulation:

[0029] 100 parts of turtle shell, 20 parts of honeysuckle flower, 50 parts of salvia root, 5 parts of prepared rehmannia root, 30 parts of coptis root, 20 parts of scrophularia root, 90 parts of litchi seed, 5 parts of kudzu root, 20 parts of angelica root, 30 parts of astragalus root, 10 parts of epimedium herb, 5 parts of wolfberry fruit, 50 parts of liquorice root.

[0030] Preparation method:

[0031] Add water with a weight 15 times that of the total weight of the formula drugs, soak for 20 minutes, decoct 1 time, 2 hours each time, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an extract with a relative density of 1.00 - 1.20, add ethanol until the alcohol content is 45% - 70%, stand for 24 hours, take the supernatant, recover ethanol and continue to concentrate to a thick paste with a relative density of 1.15 - 1.35, add pharmaceutical excipients and mix them to prepare tablets.

[0032] Example 3

[0033] Formulation:

[0034] 50 parts of turtle shell, 50 parts of honeysuckle flower, 20 parts of salvia root, 50 parts of prepared rehmannia root, 1 part of coptis root, 5 parts of scrophularia root, 5 parts of litchi seed, 50 parts of kudzu root, 5 parts of angelica root, 5 parts of astragalus root, 50 parts of epimedium herb, 5 parts of wolfberry fruit, 20 parts of liquorice root.

[0035] Preparation method:

[0036] Add water with a weight 10 times that of the total weight of the formula drugs, soak for 40 minutes, decoct 2 times, 1.5 hours each time, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an extract with a relative density of 1.00 - 1.20, add ethanol until the alcohol content is 45% - 70%, stand for 24 hours, take the supernatant, recover ethanol and continue to concentrate to a thick paste with a relative density of 1.15 - 1.35, add pharmaceutical excipients and mix them to prepare granules.

[0037] Example 4

[0038] Formulation:

[0039] 20 parts of turtle shell, 30 parts of honeysuckle flower, 5 parts of salvia miltiorrhiza, 30 parts of rehmannia root, 5 parts of coptis root, 50 parts of scrophularia root, 50 parts of litchi seed, 40 parts of kudzu root, 50 parts of angelica sinensis, 100 parts of astragalus membranaceus, 5 parts of epimedium herb, 50 parts of wolfberry fruit, 10 parts of licorice root.

[0040] Preparation method:

[0041] Add water with a weight 8 times that of the total weight of the formulated drugs, soak for 30 minutes, decoct twice, each time for 2 hours, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an appropriate amount, centrifuge with a high-speed centrifuge, add water to the specified amount, package, sterilize, and obtain the liquid drug, thus obtained.

[0042] Example 5

[0043] Formulation:

[0044] 5 parts of turtle shell, 40 parts of honeysuckle flower, 20 parts of salvia miltiorrhiza, 30 parts of rehmannia root, 10 parts of coptis root, 40 parts of scrophularia root, 40 parts of litchi seed, 40 parts of kudzu root, 30 parts of angelica sinensis, 20 parts of astragalus membranaceus, 15 parts of epimedium herb, 20 parts of wolfberry fruit, 2 parts of licorice root.

[0045] Preparation method:

[0046] Add water with a weight 12 times that of the total weight of the formulated drugs, soak for 50 minutes, decoct twice, each time for 1 hour, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an extract with a relative density of 1.00 - 1.20, add ethanol to make the ethanol content 45% - 70%, let stand for 24 hours, take the supernatant, recover the ethanol and continue to concentrate to a thick paste with a relative density of 1.15 - 1.35, add pharmaceutical excipients and mix, and then prepare into pills.

[0047] Example 6

[0048] Formulation:

[0049] 20 parts of turtle shell, 10 parts of honeysuckle flower, 10 parts of salvia miltiorrhiza, 10 parts of rehmannia root, 3 parts of coptis root, 10 parts of scrophularia root, 30 parts of litchi seed, 10 parts of kudzu root, 10 parts of angelica sinensis, 20 parts of astragalus membranaceus, 10 parts of epimedium herb, 10 parts of wolfberry fruit, 5 parts of licorice root.

[0050] Preparation method:

[0051] Add water with a weight equivalent to 10 times the total weight of the formulated medicine, soak for 30 minutes, decoct 3 times, 2 hours each time, filter, combine the filtrates, then concentrate the filtrates under reduced pressure to an extract with a relative density of 1.00 - 1.20, add ethanol to make the ethanol content 45% - 70%, let stand for 24 hours, take the supernatant, recover the ethanol and continue to concentrate to a thick paste with a relative density of 1.15 - 1.35, add pharmaceutical excipients and mix, and then prepare into capsules.

[0052] Clinical trials of the traditional Chinese medicine composition of the present invention

[0053] 1. General information

[0054] Select 120 male patients diagnosed with oligoasthenospermia and diabetes from November 2018 to September 2022 who were treated in Zhongda Hospital Affiliated to Southeast University, and randomly divide them into a control group and a treatment group. There are 54 cases in the control group and 66 cases in the treatment group. The patients are 25 - 50 years old, with an average age of 35 years. There are no statistically significant differences in baseline data such as age, disease course, and marital history between the two groups, and they are comparable.

[0055] Select 120 male patients diagnosed with erectile dysfunction and diabetes from November 2018 to September 2022 who were treated in Zhongda Hospital Affiliated to Southeast University, and randomly divide them into a control group and a treatment group. There are 51 cases in the control group and 69 cases in the treatment group. The patients are 25 - 50 years old, with an average age of 37 years. There are no statistically significant differences in baseline data such as age, disease course, and marital history between the two groups, and they are comparable.

[0056] 2. Diagnostic criteria:

[0057] Case inclusion criteria:

[0058] (1) Meeting the western medicine diagnostic criteria for abnormal semen in diabetic oligoasthenospermia (progressive motility sperm A + B grade ≤ 50%, total sperm count < 20 million), erectile dysfunction (judged according to the severity of the International Erectile Function Questionnaire - 5 (IIEF - 5), IIEF ≤ 21 points indicates that the patient has erectile dysfunction. The condition is divided into mild (12 - 21 points), moderate (8 - 11 points), and severe (5 - 7 points)), and the diagnosis is after diabetes;

[0059] (2) Diabetes has been controlled at a good level: FPG ≤ 7.0 mmol / L, 2 - hour post - prandial PG ≤ 10.0 mmol / L;

[0060] (3) Meeting the traditional Chinese medicine diagnostic criteria for yin deficiency and damp - heat, qi stagnation and blood stasis in diabetic oligoasthenospermia, abnormal semen, and erectile dysfunction;

[0061] (4) Male patients aged 25 - 50 years old, with the same conditions and normal sexual desire;

[0062] (5) Those who have voluntarily signed the informed consent form.

[0063] Those who meet the above five criteria meet the inclusion criteria.

[0064] Case exclusion criteria:

[0065] (1) Patients with type 1 diabetes or type 2 diabetes patients without sexual life;

[0066] (2) Patients with combined liver and kidney function, hematopoietic system disorders, cardiovascular diseases, and mental illnesses;

[0067] (3) Patients with combined diseases such as urethritis, acute prostatitis, and urinary system stones;

[0068] (4) Those who have been taking diuretics, antihypertensive drugs, sedatives, antidepressants, hormones and related drugs for a long time;

[0069] (5) Those with a history of pelvic surgery within 6 months.

[0070] Those who meet any one of the above five criteria, even if they meet the inclusion criteria, the researchers will exclude the patients and not include them in this study.

[0071] 3. Observation indicators, evaluation criteria

[0072] Observation indicators: The effective rate of erectile dysfunction and oligoasthenospermia treatment. Marked effect: After treatment, discomfort symptoms such as erectile dysfunction and oligoasthenospermia are all relieved; Effective: After treatment, discomfort symptoms such as erectile dysfunction and oligoasthenospermia are all alleviated. Ineffective: Do not meet the above criteria.

[0073] The effective rate of erectile dysfunction and oligoasthenospermia treatment = the sum of the percentages of marked effect and effective cases in the total number of cases.

[0074] 4. Treatment methods

[0075] Control group: Basic diabetes treatment. Treatment group: Select the above compound granule for treating male reproductive complications of diabetes (obtained from Example 1, the daily dose is: 20 parts of turtle shell, 10 parts of honeysuckle, 10 parts of salvia miltiorrhiza, 10 parts of rehmannia glutinosa, 3 parts of coptis chinensis, 10 parts of scrophularia ningpoensis, 30 parts of litchi seed, 10 parts of pueraria lobata, 10 parts of angelica sinensis, 20 parts of astragalus membranaceus, 10 parts of epimedium, 10 parts of wolfberry fruit, 5 parts of licorice), take it with boiling water, twice a day.

[0076] 5. Statistical results:

[0077] (1) Therapeutic effects of two groups: Among 66 cases in the treatment group, 40 cases showed marked effect, 16 cases showed effective, 10 cases showed ineffective, and the total effective rate was 84.8%; among 54 cases in the control group, 12 cases showed marked effect, 11 cases showed effective, 31 cases showed ineffective, and the total effective rate was 42.5%. The comparison of the total effective rates between the two groups (X2 = 12.86), P < 0.05, showing significant difference, indicating that the clinical therapeutic effect of the treatment group was significantly better than that of the control group.

[0078] (2) Therapeutic effects of two groups: Among 69 cases in the treatment group, 29 cases showed marked effect, 28 cases showed effective, 12 cases showed ineffective, and the total effective rate was 82.6%; among 51 cases in the control group, 10 cases showed marked effect, 8 cases showed effective, 33 cases showed ineffective, and the total effective rate was 35.3%. The comparison of the total effective rates between the two groups (X 2 = 12.86), P < 0.05, showing significant difference, indicating that the clinical therapeutic effect of the treatment group was significantly better than that of the control group.

[0079] 5. Safety

[0080] No obvious adverse reaction events occurred in both groups of patients during the treatment period.

[0081] In the description of this specification, the descriptions referring to terms such as "one embodiment", "example", "specific example", etc. mean that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representations of the above terms do not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in a suitable manner in any one or more embodiments or examples.

[0082] The above shows and describes the basic principles, main features and advantages of the present invention. Those skilled in the art of this industry should understand that the present invention is not limited by the above embodiments. What is described in the above embodiments and the specification only illustrates the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention will have various changes and improvements, and these changes and improvements all fall within the scope of the present invention claimed.

Claims

1. A Chinese medicine composition for treating oligospermia and asthenospermia in diabetic men and / or erectile dysfunction in diabetic men, characterized in that: The invention is prepared from the following components in parts by weight: 5-100 parts of turtle shell, 5-50 parts of honeysuckle, 5-50 parts of salvia miltiorrhiza, 5-50 parts of rehmannia root, 1-30 parts of coptis root, 5-50 parts of figwort, 5-90 parts of litchi seed, 5-50 parts of kudzu root, 5-50 parts of angelica root, 5-100 parts of raw astragalus, 5-50 parts of epimedium, 5-50 parts of wolfberry and 2-50 parts of liquorice.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention is prepared from the following components in parts by weight: 20 parts of turtle shell, 10 parts of honeysuckle, 10 parts of salvia miltiorrhiza, 10 parts of rehmannia root, 3 parts of coptis root, 10 parts of figwort, 30 parts of litchi seed, 10 parts of kudzu root, 10 parts of angelica root, 20 parts of raw astragalus, 10 parts of epimedium, 10 parts of wolfberry and 5 parts of liquorice.

3. A method for preparing a Chinese medicine composition for treating oligospermia and asthenospermia in diabetic men and / or erectile dysfunction in diabetic men, characterized in that: The method comprises the following steps: weighing a prescription medicine, wherein the prescription medicine consists of the following components in parts by weight: 5-100 parts of turtle shell, 5-50 parts of honeysuckle, 5-50 parts of salvia miltiorrhiza, 5-50 parts of rehmannia root, 1-30 parts of coptis root, 5-50 parts of figwort, 5-90 parts of litchi seed, 5-50 parts of kudzu root, 5-50 parts of angelica root, 5-100 parts of raw astragalus, 5-50 parts of epimedium, 5-50 parts of wolfberry and 2-50 parts of liquorice, adding water equivalent to 5 to 15 times the total weight of the prescription medicine, soaking and then boiling, filtering after boiling, combining the filtrate, and then preparing a liquid preparation or a solid preparation to obtain the traditional Chinese medicine composition.

4. The method for preparing the Chinese medicine composition according to claim 3, characterized in that: The method for preparing the liquid preparation comprises: concentrating the filtrate under reduced pressure, centrifuging with a high-speed centrifuge, adding water, packaging, and sterilizing.

5. The method for preparing the Chinese medicine composition according to claim 3, characterized in that: The preparation method of the solid preparation comprises: concentrating the filtrate under reduced pressure to an extract with a relative density of 1.00 to 1.20, adding ethanol to an alcohol content of 45% to 70%, standing for 24 hours, taking the supernatant, recovering the ethanol and continuing to concentrate to a thick paste with a relative density of 1.15 to 1.35, adding pharmaceutical excipients and mixing, and then preparing into granules, tablets, pills or capsules.

6. The method for preparing a Chinese medicine composition according to claim 3, characterized in that: The decoction is specifically as follows: decoct 1 to 3 times, each time for 1 to 2 hours.

7. A pharmaceutical preparation, made from the Chinese medicine composition according to any one of claims 1-2 and a pharmaceutically acceptable carrier.

8. The pharmaceutical preparation according to claim 7, characterized in that The pharmaceutical preparation is in the form of granules, tablets, pills, mixtures or capsules.