A composition capable of effectively soothing and repairing sensitive skin, and a preparation method and application thereof

Abstract

This invention discloses a composition that can effectively soothe and repair sensitive skin, its preparation method, and its application, relating to the field of skincare products. The composition of this invention, by weight, comprises 5-18 parts β-glucan, 1-10 parts mannan, 8-15 parts yeast polypeptides, 1-10 parts sodium hyaluronate, 2-5 parts magnesium ascorbate phosphate, and 8-15 parts Scutellaria baicalensis root extract. This composition is mild and non-irritating, can quickly and effectively relieve skin sensitivity reactions, protect the skin barrier, and has good storage stability, not easily affected by environmental factors such as temperature and oxygen.

Description

Technical Field

[0001] This invention relates to the field of skincare products, and in particular to a composition that can effectively soothe and repair sensitive skin, its preparation method, and its application. Background Technology

[0002] Sensitive skin is a sub-stable skin condition. Unlike skin irritation and allergies, sensitive skin typically lacks obvious clinical pathological conditions and exhibits non-specific or specific immune responses. It can be considered a skin condition that shows intolerance to changes in the external environment and the skincare products used. There are many factors that can trigger sensitive skin, which can be divided into exogenous and intrinsic factors. Exogenous factors include environmental factors, lifestyle factors, and chemical substances, such as seasonal changes, air pollution and humidity, ultraviolet radiation intensity, or excessive or inappropriate use of daily cosmetics, hair dyes, and detergents, all of which can induce skin sensitivity. Intrinsic factors include endocrine factors, genetic inheritance, diseases, and menstrual cycles. For example, different populations and individuals exhibit different levels of skin sensitivity due to genetic differences. Endocrine imbalances can also lead to weakened skin resistance and enhanced skin immune responses, causing skin sensitivity. Therefore, for people with sensitive skin, the appropriate use of skincare products is essential.

[0003] There are numerous products on the market targeting sensitive skin. Before 2010, foreign brands such as Avène, Vichy, La Roche-Posay, and Fancl dominated. However, due to differences in skin conditions between Eastern and Western consumers, these foreign skincare products were not the first choice for Asians. Against this backdrop, Chinese skincare brands, with their abundant plant resources, have also found new development opportunities. Related research indicates that Centella asiatica extract, Prickly pear fruit extract, Edelweiss extract, Portulaca oleracea extract, Chamomile extract, and Licorice extract are among the most sought-after natural ingredients for sensitive skin. They are gentle, non-irritating, and have the effect of repairing the skin barrier and deeply moisturizing. However, these products are usually less stable; the active ingredients in the extracts are easily affected by environmental factors such as light, temperature, and oxygen, and their effects are slow, often requiring continuous use for a long period to achieve the desired results, making it difficult to meet people's daily anti-sensitivity needs.

[0004] Therefore, there is an urgent need to provide a product suitable for sensitive skin that is stable, effective, and fast-acting. Summary of the Invention

[0005] This invention aims to at least solve one of the technical problems existing in the prior art. To this end, this invention proposes a composition that can effectively soothe and repair sensitive skin. By rationally combining β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, and Scutellaria baicalensis root extract, it significantly improves its anti-sensitivity effect and has the advantages of being gentle, stable, and fast-acting.

[0006] The present invention also proposes a method for preparing a composition that can effectively soothe and repair sensitive skin.

[0007] This invention also proposes the application of a composition that can effectively soothe and repair sensitive skin in the preparation of products having any one of the following functions (A1) to (A6).

[0008] A1) Soothes burning skin;

[0009] A2) Relieves itchy skin;

[0010] A3) Reduces skin tightness;

[0011] A4) Relieves skin erythema;

[0012] A5) Relieves skin irritation;

[0013] A6) Relieves dry, flaky skin.

[0014] In a first aspect, the present invention provides a composition that can effectively soothe and repair sensitive skin, comprising, by weight, the following raw materials:

[0015] 5-18 parts β-glucan, 1-10 parts mannan, 8-15 parts yeast polypeptides, 1-10 parts sodium hyaluronate, 2-5 parts magnesium ascorbate phosphate, and 8-15 parts Scutellaria baicalensis root extract.

[0016] Beta-glucan has the ability to moisturize and repair damaged skin, increasing skin hydration and providing a soothing effect. Magnesium ascorbate phosphate is a compound formed by the combination of vitamin C and phosphate groups. Similar to vitamin C, magnesium ascorbate phosphate has antioxidant properties, neutralizing free radicals and reducing oxidative stress damage to the skin. However, compared to vitamin C, magnesium ascorbate phosphate has better stability and is less prone to oxidation and degradation. It can provide long-lasting antioxidant and whitening effects in skincare products. The combined use of both helps enhance the skin's moisturizing and repair effects.

[0017] In addition, magnesium ascorbate phosphate has a certain anti-inflammatory effect, which can reduce inflammatory response and promote skin repair and regeneration. When used in combination with β-glucan, it can enhance its antioxidant effect and help the skin resist oxidative stress.

[0018] Scutellaria baicalensis root extract is a natural plant extract extracted from the root of Scutellaria baicalensis. It contains a variety of active ingredients. When used in combination with magnesium ascorbate phosphate, it can neutralize free radicals, enhance antioxidant protection, and reduce the damage of oxidative stress to the skin.

[0019] In some embodiments of the present invention, the β-glucan is composed of β-glucan with a molecular weight of 1000 kDa or higher and β-glucan with a molecular weight of 100 kDa or lower. In the compositions of the present invention, β-glucan with a molecular weight of 100 kDa or lower more easily penetrates the skin surface and binds to receptors on skin cells, thereby producing effects such as anti-sensitivity and immunomodulation, and helping to improve anti-inflammatory effects. β-glucan with a molecular weight of 1000 kDa or higher is more conducive to forming a film with moisturizing and barrier functions on the skin surface, helping to prevent moisture evaporation and the invasion of external irritants, and improving moisturizing effects.

[0020] Furthermore, using it in combination with yeast peptides helps β-glucan with a molecular weight of less than 100kDa to be absorbed and utilized by the skin more quickly, thereby exerting its bioactivity more effectively.

[0021] In some embodiments of the present invention, the weight ratio of β-glucan with a molecular weight of 1000 kDa or higher to β-glucan with a molecular weight of 100 kDa or lower is 1:0.5 to 2. An excessively high proportion of β-glucan with a molecular weight of 1000 kDa or higher can easily lead to acne breakouts and is unlikely to effectively soothe skin erythema, presumably related to poor skin breathability; while an excessively low proportion cannot effectively block the invasion of external irritants and the evaporation of moisture.

[0022] In some embodiments of the present invention, the Scutellaria baicalensis root extract contains more than 70% baicalin; preferably, it contains 80-90% baicalin. The Scutellaria baicalensis root extract is a natural plant extract extracted from the roots of Scutellaria baicalensis. It contains various active ingredients, the main active ingredients being baicalin and baicalein. Baicalin can inhibit inflammatory responses and the release of inflammatory mediators, alleviating inflammatory symptoms and exhibiting excellent anti-inflammatory effects; baicalein has certain efficacy in inhibiting allergic reactions and alleviating allergic symptoms.

[0023] In some embodiments of the present invention, the raw materials for preparation further include 40 to 60 parts by weight of deionized water.

[0024] In some embodiments of the present invention, the composition that can effectively soothe and repair sensitive skin comprises, by weight, the following raw materials: 5-18 parts of β-glucan, 1-10 parts of mannan, 8-15 parts of yeast polypeptides, 1-10 parts of sodium hyaluronate, 2-5 parts of magnesium ascorbate phosphate, 8-15 parts of Scutellaria baicalensis root extract, and 40-60 parts of deionized water.

[0025] In some embodiments of the present invention, the composition that can effectively soothe and repair sensitive skin comprises, by weight, the following raw materials: 10-18 parts of β-glucan, 5-8 parts of mannan, 8-10 parts of yeast polypeptides, 5-10 parts of sodium hyaluronate, 3-5 parts of magnesium ascorbate phosphate, 10-15 parts of Scutellaria baicalensis root extract, and 41-54 parts of deionized water.

[0026] A second aspect of the present invention provides a method for preparing the composition described in the first aspect that can effectively soothe and repair sensitive skin, comprising mixing the preparation raw materials β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water to obtain the composition.

[0027] Since this preparation method incorporates all the technical solutions of the composition described in the first aspect that can effectively soothe and repair sensitive skin, it has at least all the beneficial effects brought about by the technical solutions of the above embodiments.

[0028] In some embodiments of the invention, the mixing is performed under sterile conditions.

[0029] A third aspect of the present invention provides the use of the composition described in the first aspect, which effectively soothes and repairs sensitive skin, in the preparation of anti-sensitivity products.

[0030] According to the application of the embodiments of the present invention, at least the following beneficial effects are achieved: the anti-sensitivity product made by using the composition of the present invention that can effectively soothe and repair sensitive skin can quickly and effectively relieve skin sensitivity reactions, protect the skin barrier, and has good storage stability, is gentle and non-irritating, and is suitable for use on sensitive skin.

[0031] In some embodiments of the present invention, the anti-sensitivity product includes at least one of lotion, eye cream, face cream, toner, and ointment.

[0032] In some embodiments of the present invention, the amount of the composition that can effectively soothe and repair sensitive skin is 5-60% (v / v).

[0033] In some embodiments of the present invention, the anti-allergy product is an emulsion, and the raw materials for preparing the emulsion further include at least one of humectant, thickener, stabilizer, emulsifier, preservative, and pH adjuster.

[0034] In some embodiments of the present invention, the moisturizer includes at least one selected from sodium pyrrolidone carboxylate, dipropylene glycol, propylene glycol, glycerin, *Chlorella vulgaris* extract, ceramide 3, butylene glycol, and 1,2-hexanediol.

[0035] In some embodiments of the present invention, the thickener includes at least one of xanthan gum, carbomer, and triethanolamine.

[0036] In some embodiments of the present invention, the stabilizer includes at least one of caprylic / capric triglyceride, hydroxyethyl urea, and sodium hydroxide.

[0037] In some embodiments of the present invention, the emulsifier includes SEPIPLUS. TM At least one of 400, glyceryl stearate, and sodium cetearyl sulfate.

[0038] In some embodiments of the present invention, the preservative includes at least one of p-hydroxyacetophenone, p-hydroxybenzoate, ethylhexylglycerin, benzoic acid, and phenoxyethanol.

[0039] In some embodiments of the present invention, the pH adjuster includes at least one of triethanolamine, tartaric acid, malic acid, citric acid, sodium bicarbonate, and disodium hydrogen phosphate.

[0040] In some embodiments of the present invention, the raw materials for preparing the anti-sensitive lotion include the composition described in the first aspect that effectively soothes and repairs sensitive skin, glycerin, xanthan gum, 1,3-propanediol, caprylic / capric triglyceride, and SEPIPLUS. TM 400, glyceryl stearate, p-hydroxyacetophenone, 1,2-hexanediol and deionized water.

[0041] In some embodiments of the present invention, the anti-sensitivity emulsion comprises, by weight, the following raw materials:

[0042] The first aspect describes a composition that effectively soothes and repairs sensitive skin, comprising 10-20 parts of glycerin, 1-5 parts of xanthan gum, 2-8 parts of 1,3-propanediol, 5-8 parts of caprylic / capric triglyceride, and SEPIPLUS. TM 400 1-5 parts, glyceryl stearate 2-5 parts, p-hydroxyacetophenone 0.2-1 part, 1,2-hexanediol 1-5 parts and deionized water 50-70 parts.

[0043] Other features and advantages of the invention will be set forth in the description which follows, and will be apparent in part from the description, or may be learned by practicing the invention. Attached Figure Description

[0044] The present invention will be further described below with reference to the accompanying drawings and embodiments, wherein:

[0045] Figure 1 A diagram showing the skin condition before using the composition of Example 4 of the present invention;

[0046] Figure 2 This is a skin condition diagram after 7 days of using the composition of Example 4 of the present invention. Detailed Implementation

[0047] The following will describe the concept and technical effects of the present invention clearly and completely with reference to embodiments, so as to fully understand the purpose, features and effects of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are all within the scope of protection of the present invention.

[0048] In the description of this invention, the terms "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples," etc., refer to specific features, structures, materials, or characteristics described in connection with that embodiment or example, which are included in at least one embodiment or example of the invention. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0049] Unless otherwise specified in the examples, the procedures should be performed under standard conditions or conditions recommended by the manufacturer. Reagents or instruments whose manufacturers are not specified are all commercially available products.

[0050] Example 1

[0051] This embodiment provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 44 parts deionized water.

[0052] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd.; the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9, which contains 85% baicalin.

[0053] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0054] This embodiment also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this embodiment that effectively soothes and repairs sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, and SEPIPLUS. TM 400 1 part, glyceryl stearate 2 parts, p-hydroxyacetophenone 0.5 parts, 1,2-hexanediol 1 part and deionized water 65.5 parts.

[0055] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0056] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0057] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0058] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0059] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0060] Example 2

[0061] This embodiment provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 44 parts deionized water.

[0062] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:0.5. The yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0063] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0064] This embodiment also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this embodiment that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0065] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0066] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0067] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0068] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0069] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0070] Example 3

[0071] This embodiment provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 10 parts β-glucan, 8 parts mannan, 10 parts yeast polypeptides, 5 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 10 parts Scutellaria baicalensis root extract, and 54 parts deionized water.

[0072] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS number 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0073] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0074] This embodiment also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this embodiment that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0075] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0076] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0077] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0078] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0079] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0080] Example 4

[0081] This embodiment provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 10 parts β-glucan, 8 parts mannan, 10 parts yeast polypeptides, 5 parts sodium hyaluronate, 5 parts magnesium ascorbate phosphate, 10 parts Scutellaria baicalensis root extract, and 52 parts deionized water.

[0082] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS number 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0083] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0084] This embodiment also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this embodiment that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0085] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0086] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0087] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0088] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0089] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0090] Comparative Example 1

[0091] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 5 parts mannan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 52 parts deionized water.

[0092] The yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0093] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water, and stirring at 800 rpm for 10 minutes.

[0094] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0095] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0096] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0097] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0098] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0099] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0100] Comparative Example 2

[0101] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 59 parts deionized water.

[0102] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS number 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0103] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 minutes.

[0104] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0105] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0106] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0107] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0108] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0109] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0110] Comparative Example 3

[0111] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 52 parts deionized water.

[0112] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9, and this Scutellaria baicalensis root extract contains 85% baicalin.

[0113] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, sodium hyaluronate, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0114] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0115] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0116] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0117] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0118] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0119] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0120] Comparative Example 4

[0121] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 8 parts yeast polypeptides, 3 parts magnesium ascorbate phosphate, 15 parts Scutellaria baicalensis root extract, and 54 parts deionized water.

[0122] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd.; the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9, which contains 85% baicalin.

[0123] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, magnesium ascorbate phosphate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 min.

[0124] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0125] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0126] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0127] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0128] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0129] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0130] Comparative Example 5

[0131] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 15 parts Scutellaria baicalensis root extract, and 47 parts deionized water.

[0132] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptide was purchased from Guangzhou Qiancui Biotechnology Co., Ltd., and the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS number 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0133] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, Scutellaria baicalensis root extract and deionized water under sterile conditions at 45°C and stirring at 800 rpm for 10 minutes.

[0134] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0135] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0136] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0137] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0138] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0139] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0140] Comparative Example 6

[0141] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 15 parts β-glucan, 5 parts mannan, 8 parts yeast polypeptides, 10 parts sodium hyaluronate, 3 parts magnesium ascorbate phosphate, and 59 parts deionized water.

[0142] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd.

[0143] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate and deionized water under sterile conditions at 45°C and stirring evenly.

[0144] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0145] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0146] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0147] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0148] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0149] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0150] Comparative Example 7

[0151] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 8 parts mannan, 10 parts yeast polypeptides, 5 parts sodium hyaluronate, 5 parts magnesium ascorbate phosphate, and 72 parts deionized water.

[0152] The yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd.

[0153] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing mannan, yeast polypeptides, sodium hyaluronate, Scutellaria baicalensis root extract and deionized water, and stirring at 800 rpm for 10 minutes.

[0154] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0155] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0156] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0157] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0158] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0159] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0160] Comparative Example 8

[0161] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 8 parts mannan, 10 parts yeast polypeptides, 5 parts sodium hyaluronate, 10 parts Scutellaria baicalensis root extract, and 67 parts deionized water.

[0162] The yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd.; the Scutellaria baicalensis root extract was purchased from Shanxi Yulai Biotechnology Co., Ltd., CAS No. 94279-99-9. This Scutellaria baicalensis root extract contains 85% baicalin.

[0163] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing mannan, yeast polypeptides, sodium hyaluronate, Scutellaria baicalensis root extract and deionized water, and stirring at 800 rpm for 10 minutes.

[0164] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0165] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0166] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0167] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0168] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0169] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0170] Comparative Example 9

[0171] This comparative example provides a composition that can effectively soothe and repair sensitive skin, comprising the following components by weight: 10 parts β-glucan, 8 parts mannan, 10 parts yeast polypeptides, 5 parts sodium hyaluronate, and 67 parts deionized water.

[0172] The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa, with a weight ratio of 1:1; the yeast polypeptides were purchased from Guangzhou Qiancui Biotechnology Co., Ltd.

[0173] The above-mentioned composition that can effectively soothe and repair sensitive skin is prepared by mixing β-glucan, mannan, yeast polypeptides, sodium hyaluronate and deionized water under sterile conditions at 45°C and stirring evenly.

[0174] This comparative example also provides an anti-sensitive lotion, which, by weight, contains 15 parts of the composition provided in this comparative example that can effectively soothe and repair sensitive skin, 5 parts of glycerin, 1 part of xanthan gum, 4 parts of 1,3-propanediol, 5 parts of caprylic / capric triglyceride, 1 part of SEPIPLUSTM400, 2 parts of glyceryl stearate, 0.5 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol, and 65.5 parts of deionized water.

[0175] The above-mentioned method for preparing the anti-sensitivity emulsion includes the following steps:

[0176] Step S1: Mix deionized water, xanthan gum and 1,3-propanediol, stir and heat to 85°C to obtain an aqueous phase;

[0177] Step S2, add caprylic / capric triglyceride, SEPIPLUS TM 400 and glyceryl stearate were mixed, stirred and heated to 80°C to obtain the oil phase. Then the oil phase raw material was poured into the aqueous phase and homogenized at 8000 rpm for 5 min to obtain the crude emulsion.

[0178] Step S3: Mix p-hydroxyacetophenone and 1,2-hexanediol and heat to 85°C to melt them into a homogeneous transparent liquid. Then add the mixture to the crude emulsion and stir while cooling to 45°C to obtain the emulsion.

[0179] Step S4: At room temperature, mix the composition that can effectively soothe and repair sensitive skin with glycerin, then add it to the above lotion and stir well to obtain an anti-sensitive lotion.

[0180] Performance testing

[0181] (I) Moisturizing ability test

[0182] Test instrument: Delfin VapoMeter SWL5201 transdermal moisture loss meter (Finland).

[0183] Test principle: Transepidermal water loss (TEWL) can be used to characterize the loss of moisture in the stratum corneum and is an important standard for evaluating the barrier function of the stratum corneum. The lower the TEWL value of the skin, the better the skin barrier function, and vice versa.

[0184] Test samples: Anti-sensitivity emulsions prepared in Examples 1-4 and anti-sensitivity emulsions prepared in Comparative Examples 1-8.

[0185] Test Method: 130 female volunteers aged 20-35 years were selected. The volunteers had no systemic diseases or other skin conditions and had not used other skincare products within the past week. The 130 volunteers were randomly divided into 13 groups of 10 each. Each group applied the anti-sensitivity lotion prepared in Examples 1-4 and Comparative Examples 1-9 to their faces three times a day (morning, noon, and evening) for 7 consecutive days. The transdermal water loss (TEWL) value of each group's face was measured before and after application (on day 7) using a skin moisture loss tester. The average value was calculated as the transdermal water loss rate (g / m³). 2 h), the rate of change = (after use - before use) / before use × 100%. The smaller the rate of change, the slower the moisture loss and the better the skin's barrier function.

[0186] The test results are shown in Table 1 below.

[0187] Table 1: Transdermal Water Loss Rate Data

[0188] Group (Lotion) Tewl value before use Tewl value after use Rate of change (%) Example 1 24.54 20.78 -15.32 Example 2 25.13 20.67 -17.75 Example 3 24.44 20.94 -14.32 Example 4 24.65 20.87 -15.33 Comparative Example 1 25.85 23.95 -7.35 Comparative Example 2 24.84 23.11 -6.96 Comparative Example 3 25.45 23.93 -5.97 Comparative Example 4 25.65 24.04 -6.28 Comparative Example 5 25.41 24.87 -2.13 Comparative Example 6 24.94 23.54 -5.61 Comparative Example 7 25.77 24.65 -4.35 Comparative Example 8 25.89 25.54 -1.35 Comparative Example 9 24.57 24.18 -1.59

[0189] As shown in Table 1, the TEWL values ​​of volunteers in all groups decreased after using the anti-sensitivity lotion prepared in the embodiments or comparative examples of this invention, indicating that the skin barrier function was improved. Furthermore, Table 1 shows that the simultaneous addition of β... - The anti-sensitivity lotion prepared from dextran, mannan, yeast polypeptides, sodium hyaluronate, magnesium ascorbate phosphate, and Scutellaria baicalensis root extract (as in Examples 1-4) showed the most significant improvement effect. After continuous use for 7 days, the TEWL value decreased by more than 12%, indicating that the anti-sensitivity lotion of the present invention can quickly and effectively improve the skin's moisturizing ability and has an emergency effect, making it very suitable for modern young people.

[0190] Compared with Example 1, Example 2 has a higher content of β-glucan with a molecular weight of over 1000 kDa. The test results show that the anti-sensitivity emulsion prepared in Example 2 has a better moisturizing effect, indicating that combining it with high molecular weight β-glucan helps to quickly improve the moisturizing effect.

[0191] When comparing Example 1 with Example 4, although Comparative Examples 1-7 can improve skin moisturizing ability to a certain extent, the effect is slow to appear.

[0192] (II) Erythrocyte hemolysis test

[0193] Testing instruments: biochemical incubator, ultraviolet spectrophotometer;

[0194] Testing principle: The erythrocyte hemolysis test is used to evaluate the eye irritation effect of the test substance based on the principle of the damage degree of chemical substances to hemoglobin and cell membranes.

[0195] Test samples: Compositions that can effectively soothe and repair sensitive skin provided by Examples 1-4 and Comparative Examples 1-9, and anti-sensitivity lotions provided by Examples 1-4 and Comparative Examples 1-9.

[0196] Testing method: Dilute each test sample with normal saline to mass fractions of 0.1%, 0.2%, 0.3%, 0.5%, 1%, 2%, 10% and 20% respectively, with a volume of 2 mL. Take 500 μL of the prepared sample and 500 μL of erythrocytes with a mass fraction of 2% and mix well. Set up negative control (normal saline) and positive control (1% SDS by mass fraction). For the control (normal saline) and positive control (1% SDS by mass fraction), set 3 parallels in each group, leave them static in a 37°C biochemical incubator for 3 h, then centrifuge each group of samples and take 10 μL of the supernatant and 90 μL of normal saline and place them in a 96-well plate and mix well to measure the absorbance values at 410, 540 and 575 nm. Take the average value of each group and calculate the ratio (L / D) of the concentration of the test substance (HC50) when 50% of erythrocytes undergo hemolysis to the hemoglobin denaturation rate (DI).

[0197] Judge the erythrocyte hemolytic irritation classification based on the value of L / D: L / D > 100: non-irritating; 10 < L / D ≤ 100: slightly irritating; 1 < L / D ≤ 10: mildly irritating; 0.1 < L / D ≤ 1: moderately irritating; L / D ≤ 0.1: severely irritating.

[0198] List the L / D ratios and erythrocyte hemolytic irritation classification results of each sample in Table 2. [[ID=​​​​​​​​​As can be seen from the results of the red blood cell hemolysis stimulation test in Table 2, the composition and anti-sensitivity lotion of the present invention that can effectively soothe and repair sensitive skin are gentle and non-irritating. Furthermore, according to the comparative data of Example 1 and Example 2, it can be seen that appropriately increasing the content of β-glucan with a molecular weight of less than 100kDa helps to improve the anti-sensitivity effect of the composition.

[0203] (III) Product Stability Testing

[0204] This test examined the storage stability of the anti-sensitivity emulsions prepared in Examples 1-4 and Comparative Examples 1-9. The test products were placed in two constant-temperature incubators with temperatures set at 5°C and 40°C, respectively. The 5°C incubator was used to maintain the product's appearance and odor, serving as a standard sample; the 40°C incubator was used for accelerated testing, serving as an environmentally destructive sample. The test verified the following items: microbiological stability (e.g., total bacterial count, mold and yeast), appearance stability (e.g., color change, precipitation, stratification), and odor stability, with a storage period of 6 months.

[0205] The evaluation criteria for this test case are as follows:

[0206] 5 points: All features of the product are completely consistent with the standard sample;

[0207] 4.5 points: The product is acceptable, but there are slight differences compared to the standard sample;

[0208] 4 points: The product is acceptable, but there are some differences compared to the standard sample;

[0209] 3.5 points: The product is acceptable, but there is no significant difference compared to the standard sample;

[0210] 3 points: The product is neither acceptable nor unacceptable.

[0211] 2.5 stars: The product is slightly unacceptable;

[0212] 2 stars: The product is somewhat unacceptable;

[0213] 1.5 stars: The product is clearly unacceptable;

[0214] 1 point: The product is completely unacceptable.

[0215] The results were averaged. A score of 3 is an acceptable threshold; reaching this score indicates that the product has reached its shelf life.

[0216] The stability of the lotion made from the composition of this invention, which can effectively soothe and repair sensitive skin, is shown in Table 3.

[0217] Table 3: Results of microbial stability test under storage conditions at 40℃

[0218]

[0219] As can be seen from the table above, the lotion made using the composition of this invention that can effectively soothe and repair sensitive skin has good stability and still exhibits excellent stability after being stored at 40°C for 6 months.

[0220] Compared with the anti-sensitivity emulsion prepared in the embodiments of the present invention, Comparative Examples 5, 8 and 9 all showed varying degrees of precipitation. Although it was difficult to distinguish in general, it could be observed upon close inspection. It is speculated that this is related to the addition of magnesium ascorbate phosphate. Magnesium ascorbate phosphate is a stable form of vitamin C and has certain antioxidant properties. It can help resist free radical damage, slow down the oxidation reaction of active ingredients in the product, and thus extend the shelf life of the product.

[0221] (IV) Evaluation of People with Sensitive Skin

[0222] Using a public opinion poll rating method, 390 volunteers with sensitive skin, aged 18-55, were recruited and divided into 13 groups of 30 people each. Each group applied the anti-sensitivity lotion prepared in Examples 1-4 and Comparative Examples 1-9 to their faces three times a day, once in the morning, once at noon, and once in the evening, for seven consecutive days. Volunteers rated the lotion based on their own experience.

[0223] The total score is 5 points: 1 point is poor, 2 points is quite poor, 3 points is average, 4 points is good, and 5 points is excellent. The average score of each group is taken, and the results are shown in Table 4.

[0224] Table 4: Results of volunteers' experiences using the anti-sensitivity lotion

[0225]

[0226] Table 4 shows that the anti-sensitivity lotion prepared in this invention can effectively improve skin erythema and effectively relieve skin tightness, stinging, and itching. A volunteer with sensitive skin who was randomly selected to use the lotion of Example 4 was observed to have skin erythema before and after use as follows: Figure 1 and Figure 2 As shown, where Figure 1 This is a picture of the skin condition before use. Figure 2 The images show the skin condition after 7 days of continuous use. The comparison shows that the skin erythema was significantly improved, indicating that the composition of the present invention can improve erythema in sensitive skin.

[0227] The embodiments of the present invention have been described in detail above. However, the present invention is not limited to the above embodiments. Within the scope of knowledge possessed by those skilled in the art, various changes can be made without departing from the spirit of the present invention. Furthermore, the embodiments of the present invention and the features thereof can be combined with each other unless otherwise specified.

Claims

1. A composition capable of effectively soothing and repairing sensitive skin, characterized in that it comprises: The raw materials are prepared by the following components in parts by weight: 10-18 parts of β-glucan, 5-10 parts of mannans, 8-10 parts of yeast polypeptides, 5-10 parts of sodium hyaluronate, 3-5 parts of magnesium ascorbyl phosphate, 10-15 parts of Scutellaria baicalensis Georgi root extract, and 41-54 parts of deionized water. The Scutellaria baicalensis Georgi root extract contains more than 70% of baicalin.

2. The composition of claim 1, wherein: The β-glucan is composed of β-glucan with a molecular weight of more than 1000 kDa and β-glucan with a molecular weight of less than 100 kDa.

3. The composition of claim 2, wherein: The β-glucan having a molecular weight of 1000 kDa or more and the β-glucan having a molecular weight of 100 kDa or less The weight ratio of the β-glucan having a molecular weight of 1000 kDa or more and the β-glucan having a molecular weight of 100 kDa or less is 1:0.5-2.

4. The composition of claim 1, wherein: The Scutellaria baicalensis Georgi root extract contains 80%-90% of baicalin.

5. A process for the preparation of a composition according to any one of claims 1 to 4, characterised in that: The preparation of the raw materials is completed by mixing the raw materials.

6. Use of the composition capable of effectively soothing and repairing sensitive skin according to any one of claims 1-4 in the preparation of an anti-sensitivity product.

7. Use according to claim 6, characterized in that: The product includes at least one of emulsion, eye cream, face cream, toner, and ointment.

8. Use according to claim 6, characterized in that: The added amount of the composition capable of effectively soothing and repairing sensitive skin is 5-60% (v / v).

9. Use according to claim 8, characterized in that: The anti-sensitivity product is emulsion, and the preparation of the emulsion further includes at least one of humectants, thickening agents, stabilizers, emulsifiers, preservatives, and pH regulators.

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