A wet compress gel and its use

Abstract

The present application belongs to the technical field of hydrogel dressings, and particularly relates to a wet compress gel and application thereof. The wet compress gel comprises a functional component and a gel component; the functional component comprises composite silica gel balls, aluminum hydroxide, calcium carbonate and magnesium carbonate; the wet compress gel is packed in a breathable outer layer of a package to obtain a wet compress gel bag. In use, the wet compress gel bag can be heated by a microwave oven or hot water to apply heat to human skin, and the mineral beneficial factors can be released to the human body through the silica coating of deep-sea mud and shell powder; the obtained wet compress gel bag has excellent cold storage and heat storage performance, and the gel material has stable performance and better durability, and still has good cold storage and heat storage performance after multiple uses; the wet compress gel bag gel of the present application combines beneficial minerals and colloids, so that the gel has a Q elastic feel, and solves the common poor feel problem of cold and hot compress gels on the market which have strong flowability or weak resilience.

Description

TECHNICAL FIELD

[0001] The present application belongs to the technical field of hydrogel dressings, in particular to a wet compress gel and its application. BACKGROUND

[0002] Physical therapy plays an increasingly important role in the modern medical team, which achieves the therapeutic effect through the characteristics of physical factors such as sound, light, water, electricity, cold, heat, etc. Among various physical therapy methods, cold compress and hot compress are the most commonly used methods.

[0003] When cold compress is performed, in addition to the body temperature beginning to decrease, it also causes blood vessels to constrict and metabolic rate to decrease, so as to achieve the purpose of relieving pain and alleviating inflammation. Hot compress causes the body temperature to rise, causing blood vessels to relax and increasing the body's metabolic rate, so as to achieve the effect of increasing the elasticity of ligaments, joint capsules and muscles, and promoting healing.

[0004] The medium of the traditional cold and hot compress method mostly uses a towel or a hot water bag, one cold and one hot, which are used alternately, and the use is not convenient; and there is a lack of energy storage medium, resulting in poor durability of the effect.

[0005] A cold and hot compress product and a preparation method thereof are disclosed in Chinese Patent Publication No. CN110772372A, which preparation includes the following steps: weighing the following raw materials according to the percentage by weight: acrylamide 5%-25%, hydroxymethyl acrylamide 1%-10%, glycerol 15-35%, sodium chloride 0.1-1%, water 30-50%; first add water and glycerol to the reaction kettle, then add acrylamide, hydroxymethyl acrylamide and sodium chloride, and then stir together to prepare standby material; fill the standby material in an outer bag, press the outer bag containing the standby material with a flat weight for a period of time, and then an elastic gel body is formed in the outer bag; remove the outer bag and wrap the elastic gel body with a cloth, and then wrap the cloth along the shape of the elastic gel body. The cold and hot compress bag has both cold storage and heat storage functions, but the cold storage and heat storage capacity is poor after a period of use, which cannot meet the actual needs and the use feels poor. SUMMARY

[0006] In view of the above problems existing in the prior art, the purpose of the present application is to provide a wet compress gel and its application.

[0007] In order to solve the above problems, the technical scheme adopted by the present application is as follows:

[0008] A wet compress gel, comprising a functional component and a gel component; the functional component comprises the following components by weight: 10-20 parts of composite silica gel balls, 1-3 parts of aluminum hydroxide, 0.5-5 parts of calcium carbonate and 0.5-5 parts of magnesium carbonate; the mass dosage ratio of the gel component to the composite silica gel balls is (3-5):1.

[0009] Optionally, the gel component comprises one or more of sodium carboxymethyl cellulose, sodium polyacrylate, xanthan gum.

[0010] Optionally, the gel component further comprises aluminum citrate.

[0011] Optionally, the gel component further comprises polyacrylamide.

[0012] Optionally, the composite silica gel ball preparation method is as follows: water is added to the deep-sea mud powder and shell powder to obtain a suspension, the suspension is mixed with silicate, then placed in a reactor, CO2 is introduced for reaction, and polyacrylamide is gradually added, after cooling, standing, and finally drying and crushing to obtain the composite silica gel ball.

[0013] Optionally, the CO2 flow rate is 0.3-0.8 L / min, the reaction temperature is 80-90℃, and the reaction time is 3-5 h; the temperature after cooling is 30-40℃, and the standing time is 12-24 h.

[0014] Optionally, the silicate is sodium silicate, sodium metasilicate or potassium silicate.

[0015] Optionally, the mass ratio of the deep-sea mud powder to the silicate and polyacrylamide is 1:(2-5):(2.5-4).

[0016] Optionally, the preparation method comprises the following steps:

[0017] S1: first, mix the components in the functional component according to the mass fraction, then dilute with water and stir uniformly;

[0018] S2: adjust the pH to 7.5-8.5, then slowly add the gel component while stirring and mixing;

[0019] S3: finally, add the aluminum citrate solution and stir uniformly, and stand to obtain the deep-sea mud gel.

[0020] The application of the above wet compress gel is to pack the wet compress gel into a packaging outer layer to obtain a wet compress gel pack, and the packaging outer layer uses a microporous breathable packaging material.

[0021] Compared with the prior art, the beneficial effects of the present application are:

[0022] (1) The wet compress gel of the present application is packed in a breathable packaging outer layer, and when hot compress is performed, the wet compress gel is heated by a microwave oven or hot water, and then the human body is hot compressed. The beneficial mineral factors can be released to the human body after being coated by the silica composite gel, and the molecular thermal motion can be promoted due to heating, thereby promoting the skin absorption of the human body;

[0023] (2) The deep-sea mud, shell powder are coated by composite silica gel to obtain gel body, polyacrylamide is added in the preparation of the gel body, the hydrogen bond is formed between the hydroxyl group on the surface of the silica and the polyacrylamide, so that the stability of the deep-sea mud gel coating is promoted, on the one hand, the aggregation of the deep-sea mud is reduced, the uniformity and stability of the system are better, on the other hand, the surface area of the silica gel is increased by coating, and the thermal conductivity is lower, so that the obtained wet compress gel bag has excellent cold storage performance, and the gel material is stable and has better durability, and the cold storage performance is still good after multiple uses;

[0024] (3) The wet compress gel has soft hand feeling, beneficial minerals and colloids are combined, so that the gel has Q elastic hand feeling, and the gel has the dual functions of cold compress and hot compress, so that the common problem of poor hand feeling of the cold and hot compress gels on the market, such as strong flowability or weak resilience, is solved. DETAILED DESCRIPTION

[0025] The application will be further described below in combination with specific embodiments.

[0026] Raw material source

[0027] The deep-sea mud is purchased from Hubei Xinyuhong Biological Medicine Technology Co., Ltd.;

[0028] The sodium polyacrylate has a number average molecular weight of 450,000;

[0029] The polyacrylamide is an anionic polyacrylamide, and has a number average molecular weight of 8,000,000;

[0030] The sodium carboxymethyl cellulose has a viscosity of 800-1,200 mpa.s and is USP grade.

[0031] The preparation method of the composite silica gel ball is as follows: the deep-sea mud powder and the shell powder are ball milled for 30 min by using a ball mill, 5 g of the deep-sea mud powder and 2 g of the shell powder are taken, 150 mL of water is added to obtain a suspension, the suspension is mixed with 10 g of sodium silicate, and then is placed in a reactor, the temperature is increased to 90 DEG C, CO2 is introduced at a flow rate of 0.5 L / min, and at the same time, polyacrylamide is slowly added, 13 g of the polyacrylamide is gradually added into the reactor within 3 h, after the addition is completed, the reaction is continued for 1 h; then the system is cooled to 30 DEG C, and is static for 12 h, finally, drying and crushing are carried out to obtain the composite silica gel ball.

[0032] Example 1

[0033] A wet compress gel is prepared by the following method:

[0034] S1: 10 g of the composite silica gel ball, 3 g of aluminum hydroxide, 3 g of calcium carbonate and 2 g of magnesium carbonate are mixed, 400 g of water is added and stirred uniformly;

[0035] S2: Add citric acid to adjust pH to between 7.5-8.5, then slowly add 1 g of sodium carboxymethyl cellulose, 2 g of sodium polyacrylate mixed, while stirring at a speed of 500 r / min, finally add 0.1 g of aluminum citrate and stir evenly, stand to get deep sea mud gel.

[0036] Cut the deep sea mud gel according to the packaging size, and glue it into the outer layer of the canvas packaging, to get a wet gel compress bag.

[0037] Example 2

[0038] A wet gel compress is prepared by the following method:

[0039] S1: Take 15 g of composite silica gel balls, 1 g of aluminum hydroxide, 5 g of calcium carbonate and 1 g of magnesium carbonate, add 400 g of water and stir evenly;

[0040] S2: Add citric acid to adjust pH to between 7.5-8.5, then slowly add 1 g of sodium carboxymethyl cellulose, 2 g of sodium polyacrylate mixed, while stirring at a speed of 500 r / min, finally add 0.1 g of aluminum citrate and stir evenly, stand to get deep sea mud gel.

[0041] Cut the deep sea mud gel according to the packaging size, and glue it into the outer layer of the canvas packaging, to get a wet gel compress bag.

[0042] Example 3

[0043] A wet gel compress is prepared by the following method:

[0044] S1: Take 20 g of composite silica gel balls, 2 g of aluminum hydroxide, 0.5 g of calcium carbonate and 5 g of magnesium carbonate, add 400 g of water and stir evenly;

[0045] S2: Add citric acid to adjust pH to between 7.5-8.5, then slowly add 0.5 g of sodium carboxymethyl cellulose, 1.5 g of sodium polyacrylate, 2 g of polyacrylamide mixed, while stirring at a speed of 500 r / min, finally add 0.2 g of aluminum citrate and stir evenly, stand to get deep sea mud gel.

[0046] Cut the deep sea mud gel according to the packaging size, and glue it into the outer layer of the canvas packaging, to get a wet gel compress bag.

[0047] Comparative Example 1

[0048] A wet gel compress is prepared by the following method:

[0049] S1: First, ball mill the deep-sea mud powder and shell powder for 30 minutes. Take 7g of deep-sea mud powder, 3g of shell powder, 3g of aluminum hydroxide, 3g of calcium carbonate and 2g of magnesium carbonate, mix them together, add 400g of water and stir evenly.

[0050] S2: Add citric acid to adjust the pH to between 7.5 and 8.5, then slowly add 1g sodium carboxymethyl cellulose and 2g sodium polyacrylate while stirring at 500r / min. Finally, add 0.1g aluminum citrate and stir evenly. Let stand to obtain deep-sea mud gel.

[0051] After cutting the deep-sea mud gel to the packaging size, glue it into the outer layer of the canvas packaging to obtain the wet compress gel pack.

[0052] Comparative Example 2

[0053] A wet compress gel is prepared using the following method:

[0054] S1: Deep-sea mud powder and shell powder are first ball-milled for 30 minutes. Take 5g of deep-sea mud powder and 2g of shell powder and add 150mL of water to prepare a suspension. Heat to 90℃ and slowly add polyacrylamide. Add 13g of polyacrylamide to the reactor gradually over 3 hours. After the addition is complete, continue the reaction for 1 hour. Then cool the system to 30℃ and let it stand for 12 hours. Then dry and pulverize to obtain composite microspheres.

[0055] Mix 10 g of composite microspheres, 3 g of aluminum hydroxide, 3 g of calcium carbonate and 2 g of magnesium carbonate, add 400 g of water and stir until homogeneous;

[0056] S2: Add citric acid to adjust the pH to between 7.5 and 8.5, then slowly add 1g sodium carboxymethyl cellulose and 2g sodium polyacrylate while stirring at 500r / min. Finally, add 0.1g aluminum citrate and stir evenly. Let stand to obtain deep-sea mud gel.

[0057] After cutting the deep-sea mud gel to the packaging size, glue it into the outer layer of the canvas packaging to obtain the wet compress gel pack.

[0058] Comparative Example 3

[0059] A wet compress gel is prepared using the following method:

[0060] S1: Deep-sea mud powder and shell powder were first ball-milled for 30 minutes. 5g of deep-sea mud powder and 2g of shell powder were added to 150mL of water to prepare a suspension. The suspension was mixed with 10g of sodium silicate and then placed in a reactor. The temperature was raised to 90℃ and CO2 was introduced at a flow rate of 0.5L / min. The reaction was carried out for 4 hours. Then the system was cooled to 30℃ and allowed to stand for 12 hours. Finally, the system was dried and pulverized to obtain silica hydrogel balls.

[0061] Take 10 g of silica gel ball, 3 g of aluminum hydroxide, 3 g of calcium carbonate and 2 g of magnesium carbonate, add 400 g of water and stir evenly;

[0062] S2: Add citric acid to adjust the pH to 7.5-8.5, then mix 1 g of sodium carboxymethyl cellulose, 2 g of sodium polyacrylate, and slowly add them while stirring at a speed of 500 r / min, finally add 0.1 g of aluminum citrate and stir evenly, and stand to get the deep-sea mud gel.

[0063] Cut the deep-sea mud gel according to the packaging size, and glue it into the outer layer of the canvas packaging, to get the wet gel compress bag.

[0064] The deep-sea mud gels obtained in Examples 1-3 and Comparative Examples 1-3 were tested for resilience and cold storage performance, and the hand feeling of the wet gel compress was tested. The test results are shown in Table 1.

[0065] Resilience: The hydrogel was made into a cylindrical gel sample with a size of 9 mm (diameter) x 9 mm (height), and the TMS-PRO texture analyzer was used to test the compression mechanical properties of the hydrogel.

[0066] Cold storage performance: After the sample was prepared, on the first day, the sample was placed in a-18℃ environment for 5h, then taken out and placed in a 20℃ constant temperature environment, a temperature recorder was fixed in the middle of the sample, the temperature change of the sample was tested, and the time taken for the sample temperature to rise from-5℃ to 5℃ was recorded; after the sample returned to room temperature, the sample was placed in 55℃ hot water for 30min, then taken out and placed in a 20℃ constant temperature environment, a temperature recorder was fixed in the middle of the sample, the temperature change of the sample was tested, and the time taken for the sample temperature to drop from 50℃ to 40℃ was recorded; on the second day, the sample was again placed in a-18℃ environment for 5h, then taken out and placed in a 20℃ constant temperature environment, after the sample returned to room temperature, the sample was placed in 55℃ hot water for 30min, then taken out and placed in a 20℃ constant temperature environment, the above operation was repeated until the 30th day, and the temperature change of the sample was recorded according to the operation on the first day.

[0067] Hand feeling evaluation: 50 volunteers were randomly selected for use, and the hand feeling of the deep-sea mud gel was scored (full score 10), finally, the average value of the evaluation results was taken after removing the 5 highest scores and 5 lowest scores, and the hand feeling evaluation score of the sample was obtained.

[0068] Table 1 Performance test results of deep-sea mud gel

[0069]

[0070] As can be seen from the results in Table 1, the first day of the test results of the cold storage and heat storage capacity, the cold storage and heat storage capacity of the comparative sample is lower than that of the sample of the application; after the continuous cold storage and heat storage cycle, the cold storage and heat storage capacity of the sample obtained by the example is basically not reduced, but the cold storage and heat storage capacity of the comparative sample is obviously decreased. And through the data in the table, it can also be seen that the sample in the example of the application has better surface smoothness, excellent resilience and better hand feeling.

[0071] The above detailed description is only an explanation of the application, which is not a limitation of the application. Those skilled in the art can make modifications to the embodiments without creative contribution after reading the specification, but as long as it is within the scope of the claims of the application, it is protected by the patent law.

Claims

1. A wet compress gel, characterized in that, It includes functional components and gel components; the functional components include the following components in parts by weight: 10-20 parts of composite silica gel spheres, 1-3 parts of aluminum hydroxide, 0.5-5 parts of calcium carbonate and 0.5-5 parts of magnesium carbonate; the mass ratio of the gel components to the composite silica gel spheres is (3-5):1; The method for preparing the composite silica gel spheres is as follows: water is added to deep-sea mud powder and shell powder to prepare a suspension. The suspension is mixed with silicate and then placed in a reactor. CO2 is introduced to carry out the reaction, and polyacrylamide is gradually added at the same time. After cooling, the mixture is allowed to stand, and finally dried and pulverized to obtain composite silica gel spheres.

2. The wet compress gel according to claim 1, characterized in that, The gel components include one or more of sodium carboxymethyl cellulose, sodium polyacrylate, and xanthan gum.

3. The wet compress gel according to claim 2, characterized in that, The gel components also include aluminum citrate.

4. The wet compress gel according to claim 2, characterized in that, The gel component also includes polyacrylamide.

5. A wet compress gel according to claim 1, characterized in that, The CO2 flow rate is 0.3-0.8 L / min, the reaction temperature is 80-90℃, and the reaction time is 3-5 h; the temperature after cooling is 30-40℃, and the settling time is 12-24 h.

6. The wet compress gel according to claim 1, characterized in that, The silicates are sodium silicate, sodium metasilicate, or potassium silicate.

7. The wet compress gel according to claim 1, characterized in that, The mass ratio of the deep-sea mud powder to silicate and polyacrylamide is 1:(2-5):(2.5-4).

8. The wet compress gel according to claim 1, characterized in that, The preparation method includes the following steps: S1: First, mix the components in the functional ingredients according to their mass parts, then add water to dilute and stir evenly; S2: Adjust the pH to 7.5-8.5, then slowly add the gel components while stirring and mixing. S3: Finally, add the aluminum citrate solution and stir well, then let it stand to obtain the deep-sea mud gel.

9. The application of a wet compress gel according to any one of claims 1-8, characterized in that, The wet compress gel is placed into the outer layer of the packaging to obtain a wet compress gel pouch, wherein the outer layer of the packaging is made of microporous breathable packaging material.

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