A complex microemulsion containing flonicamid and its preparation method and application

Abstract

The present application relates to the field of pesticides, and in particular to a kind of flonicamid-containing compound microemulsion and its preparation method and application, by mass percentage, raw material at least includes 20-30% raw drug, 20-30% solvent, 20-35% functional adjuvant, deionized water makes up the balance.The present application uses a small amount of low-toxicity solvent, with good environmental compatibility, can reduce the pollution caused by organic solvent to environment, has the use effect superior to water dispersible granule and dispersible oil suspension, stability and transmission efficiency are high, with wide development prospect.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of pesticides, in particular to the field of IPC A01, more particularly to a kind of complex microemulsion containing flonicamid and its preparation method and application. BACKGROUND

[0002] Flonicamid has significant toxic effect on the pests on crops with mouth parts, its structure is similar to that of nicotinic insecticide, but its insecticidal mechanism is different, flonicamid can make aphids produce antifeeding reaction in aphid body, aphids cannot suck plant sap, so that aphids die of hunger, so the speed of effect is poor, and a period of time is needed after application to make aphids starve to death, so the rapid control effect on aphids is not ideal.

[0003] CN 102696607 B discloses a kind of flonicamid microemulsion and its preparation method, uses flonicamid as raw drug, and is dissolved with other functional additives to obtain flonicamid microemulsion, and flonicamid microemulsion is prepared by inspection and packaging. The present application only uses flonicamid as a kind of raw drug, and the drug effect is insufficient, and when a plurality of raw drugs are compounded, the solubility of the raw drug and the stability of the prepared drug need to be solved. SUMMARY

[0004] In order to solve the above problems, the first aspect of the present application provides a kind of complex microemulsion containing flonicamid, and the raw material at least includes 12-18% flonicamid, 8-12% water-soluble raw drug, 20-30% solvent, 20-35% functional additive and deionized water to make up the rest.

[0005] As a preferred scheme, the water-soluble raw drug is at least one of trichlorphon, ethephon, acetamiprid, carbosulfan and thiodicarb.

[0006] As a preferred scheme, the water-soluble raw drug is acetamiprid.

[0007] As a preferred scheme, the mass ratio of acetamiprid to flonicamid is (10-15):(10-18).

[0008] As a preferred scheme, the mass ratio of acetamiprid to flonicamid is 1:1.5.

[0009] As a preferred scheme, the raw drug content of acetamiprid is 98%; the raw drug content of flonicamid is 97%.

[0010] As a preferred scheme, the functional additive is selected from at least one of solubilizing agent, defoaming agent, emulsifier, functional emulsifier, stabilizer and synergist.

[0011] As a preferred scheme, the functional auxiliary agent is a cosolvent, an antifoaming agent, an emulsifier, a functional emulsifier.

[0012] As a preferred technical scheme, the mass ratio of the solvent, the cosolvent, and the deionized water is (2-3):1:(1-3).

[0013] As a preferred technical scheme, the mass ratio of the solvent, the cosolvent, and the deionized water is 25:10:19.98.

[0014] As a preferred scheme, the solvent is at least one of cyclohexanone, N,N-dimethylacetamide, N,N-dimethylpropionamide, dimethyl sulfoxide, and N-methyl pyrrolidone.

[0015] As a preferred scheme, the solvent is N,N-dimethylacetamide.

[0016] As a preferred scheme, the cosolvent is at least one of solvent oil, ethanol, dimethyl carbonate, cyclohexanone, propylene carbonate, and dimethyl sulfoxide.

[0017] As a preferred scheme, the cosolvent is a combination of ethanol and dimethyl sulfoxide; the mass ratio of the ethanol and the dimethyl sulfoxide is (0.5-2.5):(0.5-1.5).

[0018] As a preferred scheme, the cosolvent is a combination of ethanol and dimethyl sulfoxide; the mass ratio of the ethanol and the dimethyl sulfoxide is (0.5-2):1.

[0019] As a preferred scheme, the cosolvent is a combination of ethanol and dimethyl sulfoxide; the mass ratio of the ethanol and the dimethyl sulfoxide is 1:1.

[0020] At present, the fluazinam and acetamiprid preparations on the market are mainly water dispersible granules and dispersible oil suspensions. However, from the market research, due to the obvious advantages of microemulsion in improving the efficacy and use effect, the dosage form is more easily accepted by users in the current national conditions, and therefore the development of fluazinam and acetamiprid microemulsion preparation has high market promotion value. However, due to the quality difference and solubility problem of fluazinam and acetamiprid technical materials on the market at present, it is difficult to prepare fluazinam and acetamiprid microemulsion preparation products with good emulsification effect to meet the needs of the current pesticide market. The inventors found that when N,N-dimethylacetamide is used as a solvent, and ethanol and dimethyl sulfoxide are used as cosolvents in a mass ratio of (0.5-2):1, especially when the mass ratio of the solvent, cosolvent and deionized water is (2-3):1:(1-3), a fluazinam and acetamiprid microemulsion preparation product with good emulsification effect can be prepared, and the microemulsion will not appear crystal precipitation after being placed at-6℃ for 7 days. The inventors analyzed the reason that: the fluazinam and acetamiprid technical materials in the system exist in a highly stable dissolved state in the N,N-dimethylacetamide, ethanol, dimethyl sulfoxide and deionized water system. When the microemulsion is placed in an environment below 0℃, the interaction ability between N,N-dimethylacetamide, ethanol, dimethyl sulfoxide and fluazinam is greater than the precipitation ability thereof at low temperature, so that fluazinam and acetamiprid can be effectively developed to prepare a microemulsion type that can withstand-6℃ low temperature to meet the market demand.

[0021] As a preferred solution, the mass ratio of the cosolvent to the emulsifier is (6-15):(12-28).

[0022] As a preferred solution, the mass ratio of the cosolvent to the emulsifier is (8-12):(15-25).

[0023] As a preferred solution, the mass ratio of the cosolvent to the emulsifier is 5:9.

[0024] As a preferred solution, the emulsifier is a non-ionic surfactant, and the HLB value of the non-ionic surfactant is 12-15.

[0025] As a preferred solution, the emulsifier is a non-ionic surfactant, and the HLB value of the non-ionic surfactant is 12.8.

[0026] As a preferred solution, the non-ionic surfactant is selected from at least one of emulsifier 601, emulsifier 602, emulsifier 603 and emulsifier 604.

[0027] As a preferred solution, the non-ionic surfactant is emulsifier 601.

[0028] Based on the system of the application, by adopting the emulsifier 601, especially controlling the mass ratio of the cosolvent, the emulsifier in the system is (8-12):(15-25), the transparency of the microemulsion product is effectively improved, a relatively wide transparent temperature range is presented, and the limitation of use season and use time is relatively small. The inventor analyzes the reason: under the joint action of the above-mentioned mass ratio of ethanol and dimethyl sulfoxide, the emulsifier 601 has sufficient affinity and compatibility with flonicamid and acetamiprid technical material, which ensures the sufficient adsorption of the emulsifier 601 on the oil-water interface, and the system transparent microemulsion product in a wide temperature range of-6℃-60℃ is obtained, if the emulsifier with low HLB value is introduced into the system, the product appears turbidity at low temperature.

[0029] As a preferred scheme, the functional emulsifier is selected from at least one of block polyether, double comb weak anionic polymer and single comb weak anionic polymer.

[0030] As a preferred scheme, the functional emulsifier is block polyether.

[0031] As a preferred technical scheme, the mass ratio of the functional emulsifier and the emulsifier is (1-3):(15-25).

[0032] As a preferred technical scheme, the mass ratio of the functional emulsifier and the emulsifier is 1:9.

[0033] The inventor found that the emulsion becomes turbid during the dilution process of the microemulsion, and the inventor found that by introducing block polyether as a functional additive, especially controlling the mass ratio of block polyether and emulsifier 601 is (1-3):(15-25), the problem of unstable emulsion after dilution of the microemulsion product in hard water with high concentration is effectively avoided. The inventor analyzes the reason: under the joint action of N,N-dimethylacetamide, ethanol and dimethyl sulfoxide, block polyether and emulsifier 601 are fully adsorbed on the oil-water interface, the dispersion system is stabilized by matching the steric hindrance effect and controlling the critical micelle concentration, so that the microemulsion can also maintain a transparent and stable emulsion state after contacting with hard water or fertilizer containing calcium ions and magnesium ions.

[0034] As a preferred technical scheme, the defoaming agent is selected from at least one of polyether defoaming agent and silicone defoaming agent.

[0035] As a preferred technical scheme, the defoaming agent is a polyether defoaming agent.

[0036] As a preferred technical scheme, the polyether defoaming agent is a non-silicone water-soluble polyether defoaming agent.

[0037] The applicant found in the actual production and research process that the use effect of the microemulsion product can be improved without affecting the stability of the system by using a polyether defoaming agent, and the microemulsion has fewer bubbles during dilution and use, facilitating spraying.

[0038] The second aspect of the present application provides a preparation method of the complex microemulsion containing flonicamid, as described above, characterized in that at least the following steps are included: (1) adding flonicamid, water-soluble technical material, solvent, functional adjuvant into a configuration kettle, and fully stirring and dissolving; (2) continuously adding deionized water under stirring, and uniformly mixing to obtain the microemulsion.

[0039] The third aspect of the present application provides an application of the complex microemulsion containing flonicamid, as described above, and the microemulsion is applied to the control of aphids and thrips.

[0040] Beneficial effects:

[0041] 1. The complex microemulsion containing flonicamid provided by the present application uses a small amount of low-toxicity solvent, has good environmental compatibility, can reduce pollution caused by organic solvents to the environment, has better use effect than water dispersible granules and dispersible oil suspensions, has high stability and transmission efficiency, and has a wide development prospect.

[0042] 2. The present application improves the interaction between N,N-dimethylacetamide as a solvent, ethanol and dimethyl sulfoxide as cosolvents, flonicamid and acetamiprid technical material, prevents the technical material from precipitating from the system, and makes the prepared microemulsion resistant to low temperature and maintain a highly stable dissolved state.

[0043] 3. The present application uses flonicamid and acetamiprid as technical material components for compounding, which can effectively improve the insecticidal activity of the prepared microemulsion, has significant synergistic durability compared with single effective component products, and can reduce the use amount of the pesticide, and can be used for the control of aphids and thrips.

[0044] 4. The present application uses emulsifier 601 which has sufficient affinity and compatibility with flonicamid and acetamiprid technical material, ensures the full adsorption of emulsifier 601 on the oil-water interface, and makes the obtained microemulsion product maintain the transparency and stability of the system in a wide temperature range.

[0045] 5. The present application controls the mass ratio of the block polyether and the emulsifier 601 to be 1:9 by introducing the block polyether as a functional emulsifier, the block polyether and the emulsifier 601 are fully adsorbed at the oil-water interface, the dispersion system is stabilized by matching the steric hindrance effect and controlling the critical micelle concentration, and the problem of unstable emulsion after dilution of the microemulsion product in high-concentration hard water is effectively avoided. BRIEF DESCRIPTION OF DRAWINGS

[0046] Figure 1 The appearance result graph of the microemulsion prepared for Example 1 of the present application after low-temperature stability test.

[0047] Figure 2 The appearance result graph of the microemulsion prepared for Comparative Example 1 of the present application after low-temperature stability test.

[0048] Figure 3 The appearance result graph of the microemulsion prepared for Example 1 (left 1-2), Comparative Example 4 (right 1), and Comparative Example 5 (right 2) of the present application after standard hard water stability test.

[0049] Figure 4 The appearance result graph of the microemulsion prepared for flonicamid from Jiangxi Huihe Chemical Co., Ltd. (left), Suzhou Aotai Chemical Co., Ltd. (middle), and Anhui Xinsite Biological Technology Co., Ltd. (right). DETAILED DESCRIPTION

[0050] Example 1

[0051] Example 1 provides a complex microemulsion containing flonicamid. The raw materials are 15% flonicamid, 10% water-soluble technical material, 25% solvent, 30.02% functional adjuvant, and deionized water to make up the balance, in terms of mass percentage.

[0052] The water-soluble technical material is acetamiprid, which is purchased from Shandong Zhongnong Joint Biological Technology Co., Ltd. with batch number 20221127726.

[0053] The flonicamid is purchased from Jiangxi Huihe Chemical Co., Ltd. with batch number 202205113004.

[0054] The technical content of acetamiprid is 98%, and the technical content of flonicamid is 97%.

[0055] The solvent is N,N-dimethylacetamide.

[0056] The functional adjuvant is 10% cosolvent, 0.02 antifoaming agent, 18% emulsifier, and 2% functional emulsifier.

[0057] The cosolvent is ethanol and dimethyl sulfoxide, and the mass ratio of the two is 1:1.

[0058] The defoaming agent is a non-silicone water-soluble polyether defoaming agent GN-5, which is purchased from Xi'an Gaoge Biotechnology Co., Ltd.

[0059] The emulsifier is emulsifier 601, which is a non-ionic surfactant with an HLB value of 12.8, and is purchased from Jiangsu Kaiyuan Technology Co., Ltd.

[0060] The functional emulsifier is a block polyether Ethylan NS-500LQ, which is purchased from Nolix Chemicals.

[0061] The second aspect of the embodiment provides a preparation method of the complex microemulsion containing flonicamid as described above, which comprises the following steps: (1) adding flonicamid, water-soluble raw material, solvent, and functional adjuvant into a configuration kettle, and fully stirring and dissolving; (2) continuously adding deionized water under stirring conditions, and uniformly mixing to obtain the product.

[0062] Comparative Example 1

[0063] The specific implementation of the comparative example is the same as that of example 1, except that the cosolvent is ethanol and dimethyl sulfoxide, and the mass ratio of the two is 4:1.

[0064] Comparative Example 2

[0065] The specific implementation of the comparative example is the same as that of example 1, except that the cosolvent is ethanol and propylene carbonate, and the mass ratio of the two is 1:1.

[0066] Comparative Example 3

[0067] The specific implementation of the comparative example is the same as that of example 1, except that the emulsifier is emulsifier BY110, and the HLB value is 10.

[0068] Comparative Example 4

[0069] The specific implementation of the comparative example is the same as that of example 1, except that the functional emulsifier is emulsifier 602, and the HLB value is 13.8, which is purchased from Jiangsu Kaiyuan Technology Co., Ltd.

[0070] Comparative Example 5

[0071] The specific implementation of the comparative example is the same as that of example 1, except that the raw material is 15% flonicamid, 10% water-soluble raw material, 28% solvent, 7% cosolvent, 0.02 defoaming agent, 18% emulsifier, 2% functional emulsifier, and deionized water to make up the balance.

[0072] Comparative Example 6

[0073] The specific implementation of the present comparative example is the same as example 1, except that the defoaming agent is a silicone-based defoaming agent, specifically polydimethylsiloxane, purchased from Sigma-Aldrich, with the product number PHR1518-1G.

[0074] Performance evaluation

[0075] I. Field efficacy test

[0076] The compound microemulsion containing flonicamid prepared in example 1 of the present application was subjected to field efficacy test. (1)

[0078] Test crop: cabbage (Jingfeng No. 1)

[0079] Control object: radish aphid (Lipaphis erysimi)

[0080] Test start time: April 16, 2022

[0081] Test completion time: May 1, 2022

[0082] Test agent: 25% flonicim · acetamiprid microemulsion (same as example 1 of the present application)

[0083] Control agent: 50% flonicamid water dispersible granules, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.; 20% acetamiprid soluble powder, purchased from Shenzhen Nuopuxin Agricultural Co., Ltd.

[0084] Spraying method and water consumption: stem and leaf spraying method, 675 liters per hectare (45 L per mu) for cabbage heart period.

[0085] The test results are shown in Table 1 below:

[0086] Table 1

[0087] (2)

[0089] Test crop: cabbage

[0090] Control object: peach aphid (Myzus persicae)

[0091] Test start time: May 27, 2022

[0092] Test completion time: June 7, 2022

[0093] Test agent: 25% flonicim · acetamiprid microemulsion (same as example 1 of the present application)

[0094] Control agent: 50% flonicarim water dispersible granules, purchased from Shaanxi Thompson Biotechnology Co., Ltd.; 20% acetamiprid soluble powder, purchased from Shenzhen Nuopxin Agricultural Co., Ltd.

[0095] Application method and water volume: 44.4 L / acre.

[0096] The test results are shown in Table 2 below:

[0097] Table 2

[0098] (3)

[0100] Test crop: cabbage (Jinlu Xiuyue)

[0101] Control object: aphids, including Myzus persicae and Brevicoryne brassicae Linnaeus

[0102] Test start time: June 15, 2022

[0103] Test completion time: June 25, 2022

[0104] Test agent: 25% flonicarim acetamiprid microemulsion (same as Example 1 of the present application)

[0105] Control agent: 50% flonicarim water dispersible granules, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.; 20% acetamiprid soluble powder, purchased from Shenzhen Nuopxin Agricultural Co., Ltd.

[0106] Application method and water volume: 40 L of pesticide liquid per mu (equivalent to 600 L / acre) was sprayed on cabbage plants using a Lini spray.

[0107] The test results are shown in Table 3 below:

[0108] Table 3

[0109] (4)

[0111] Test crop: cabbage (Daguo Jingfeng), at the rosette stage, with a row spacing of 35 cm x 40 cm.

[0112] Control object: Myzus persicae, at the initial stage of occurrence.

[0113] Test start time: May 3, 2022

[0114] Test completion time: May 10, 2022

[0115] Test agent: 25% flonicarim-thiamethoxam microemulsion (same as Example 1 of the present application)

[0116] Control agent: 50% flonicarim water dispersible granule, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.; 20% thiamethoxam soluble powder, purchased from Shenzhen Nuopuxin Agricultural Co., Ltd.

[0117] Method of application and amount of water: spraying method, amount of water 750 L / ha.

[0118] The test results are shown in Table 4 below:

[0119] Table 4

[0120] (5)

[0122] Test crop: cabbage

[0123] Control object: thrips (Thrips hawaiiensis (Morgan))

[0124] Test start time: 2022.05.23

[0125] Test completion time: 2022.06.20

[0126] Test agent: 25% flonicarim-thiamethoxam microemulsion (same as Example 1 of the present application)

[0127] Control agent: 10% flonicarim water dispersible granule, purchased from Japan Ishihara Industry Co., Ltd.; 10% thiamethoxam emulsifiable concentrate, purchased from Shandong Zhongxinke Biological Technology Co., Ltd.; 50% flonicarim-thiamethoxam water dispersible granule, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.

[0128] Method of application and amount of water: spraying method, amount of water 450 L / ha.

[0129] The test results are shown in Table 5 below:

[0130] Table 5

[0131]

[0132] Note: test with Duncan's new multiple range method, different letters in the same column in the table represent significant differences between treatments at 1% and 5% levels, the same below. (6)

[0134] Test crop: cabbage (Qingfeng)

[0135] Control object: Thrips tabaci Lindeman

[0136] Test start time: 2022.09.23

[0137] Test completion time: 2022.10.03

[0138] Test agent: 25% flonicarimethomycin microemulsion (same as example 1 of the present application)

[0139] Control agent: 10% flonicarimethomycin water dispersible granules, purchased from Ishihara Industry Co., Ltd. of Japan; 10% methomycin emulsion, purchased from Shandong Zhongxinke Biological Technology Co., Ltd.; 50% flonicarimethomycin water dispersible granules, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.

[0140] Method of application and amount of water: targeted spraying of cabbage plants with a Liniang sprayer, 45 liters of pesticide liquid per mu (equivalent to 675 liters per hectare).

[0141] The test results are shown in Table 6 below:

[0142] Table 6

[0143] (7)

[0145] Test crop: cabbage. Variety "bright ball"

[0146] Control object: thrips, mainly Thrips tabaci Lindeman and Frankliniella occidentalis (Pergande)

[0147] Test start time: 2022.06.23

[0148] Test completion time: 2022.07.03

[0149] Test agent: 25% flonicarimethomycin microemulsion (same as example 1 of the present application)

[0150] Control agent: 10% flonicarimethomycin water dispersible granules, purchased from Ishihara Industry Co., Ltd. of Japan; 10% methomycin emulsion, purchased from Shandong Zhongxinke Biological Technology Co., Ltd.; 50% flonicarimethomycin water dispersible granules, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.

[0151] Method of application and amount of water: uniform and careful spraying of whole plants, with a water consumption of 600 liters per hectare (45 liters per mu).

[0152] The test results are shown in Table 7 below:

[0153] Table 7

[0154]

[0155] Note: The experimental results in the above table were statistically analyzed by Duncan's new multiple range method. Different lowercase letters in the same column represent significant differences at the 0.05 level, and different uppercase letters represent significant differences at the 0.01 level. (8)

[0157] Test crop: cabbage (Daguo Jingfeng), rosette stage, nest planting, nest row spacing 35 cm x 40 cm.

[0158] Control object: Thrips palmi Karny nymphs at the initial stage of occurrence.

[0159] Test start time: May 2, 2022

[0160] Test completion time: May 12, 2022

[0161] Test agent: 25% flonicarimethyrid microemulsion (same as Example 1 of the present application)

[0162] Control agent: 10% flonicarimethyrid water dispersible granule, purchased from Ishihara Industry Co., Ltd. of Japan; 10% methyrid emulsifiable concentrate, purchased from Shandong Zhongxinke Biological Technology Co., Ltd.; 50% flonicarimethyrid water dispersible granule, purchased from Shaanxi Meibang Pharmaceutical Group Co., Ltd.

[0163] Method of application and amount of water: spray method, amount of water 50 liters per mu.

[0164] The test results are shown in Table 8 below:

[0165] Table 8

[0166]

[0167] Note: The same lowercase letters after the numbers indicate no significant difference at the P<0.05 level (the same below).

[0168] II. Physicochemical properties:

[0169] (1) Refer to the national standard GB / T 19136 "Pesticide Heat Storage Stability Determination Method", GB / T 28137-2011 "Pesticide Persistent Foaming Determination Method", GB / T 31737-2015 "Pesticide Pouring Determination Method", GB / T 19137-2003 "Pesticide Low Temperature Stability Determination Method" to detect the appearance, persistent foaming, heat storage stability, low temperature stability and other parameters of the flonicamid-containing compound microemulsion provided by Example 1. The experimental results meet the requirements, see Table 9 and the drawings in the specification, and the emulsion transparency test results are shown in Table 10.

[0170] As shown in Figure 1 , it is the appearance result graph of the microemulsion prepared by Example 1 of the present application after low temperature stability test; as shown in Figure 2 , it is the appearance result graph of the microemulsion prepared by Comparative Example 1 of the present application after low temperature stability test.

[0171] Table 9

[0172]

[0173] Table 10

[0174]

[0175]

[0176] As shown in Figure 3 , it is the appearance result graph of the microemulsion prepared by Example 1 (left 1-2), Comparative Example 4 (right 1), Comparative Example 5 (right 2) of the present application after standard hard water stability test.

[0177] As shown in Figure 4 , it is the appearance result graph of the microemulsion prepared by flonicamid from Jiangxi Huihe Chemical Co., Ltd. (left), Suzhou Aotai Chemical Co., Ltd. (middle), and Anhui Xinsite Biological Technology Co., Ltd. (right).

[0178] (2) Refer to NY / T1860-2016 "Pesticide Physicochemical Property Determination Test Guide" to test the flonicamid-containing compound microemulsion provided by Example 1 of the present application, and the results are as follows:

[0179] Density: 1.0681 g / cm 3 (RSD% = 0.01, n = 3);

[0180] Kinematic viscosity: 20℃, 13.9917 mPa·s (RSD% = 0.04, n = 3); 40℃, 6.8425 mPa·s (RSD% = 0.1, n = 3);

[0181] Determined flash point: flash point greater than 93°C;

[0182] Corrosion to packaging materials: The packaging material (polyethylene nylon) was not corrosive to the packaging material by the packaging material corrosion test;

[0183] Determined explosiveness: Not potentially explosive by the test;

[0184] Determined oxidation / reduction reactions (chemical incompatibility): Chemically compatible with water, common fire extinguishing agents, reducing agents, and kerosene, and chemically incompatible with moderate oxidizing agents.

Claims

1. A microemulsion concentrate comprising flonicamid, characterized in that, The raw materials are 15% flonicamid, 10% water-soluble raw material, 25% solvent, 30.02% functional additive, and deionized water to make up the rest, by mass percentage; The water-soluble raw material is acetamiprid, and the content of acetamiprid in the raw material is 98%, and the content of flonicamid in the raw material is 97%; The solvent is N,N-dimethylacetamide; The functional additive is 10% cosolvent, 0.02 antifoaming agent, 18% emulsifier, and 2% functional emulsifier; The cosolvent is ethanol and dimethyl sulfoxide, and the mass ratio of the two is 1:1; The antifoaming agent is non-silicone water-soluble polyether antifoaming agent GN-5; The emulsifier is emulsifier 601, which is a nonionic surfactant, and the HLB value is 12.8; The functional emulsifier is block polyether Ethylan NS-500LQ; The preparation method of the flonicamid-containing complex microemulsion comprises the following steps: (1) adding flonicamid, water-soluble raw material, solvent, and functional additive into a configuration kettle, and fully stirring and dissolving; (2) continuously adding deionized water under stirring, and uniformly mixing to obtain the product.

2. Use of a complex microemulsion containing flonicamid according to claim 1, characterized in that, It is used for the control of aphids and thrips.

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